pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol KRTAP5-9   
Synonyms KRN1, KRTAP5-1, KRTAP5.9
Description keratin associated protein 5-9
Transcript NM_005553   
Expression
Putative miRNA Targets on KRTAP5-9
3'UTR of KRTAP5-9
(miRNA target sites are highlighted)
>KRTAP5-9|NM_005553|3'UTR
   1 GGCTCTAGTGGGAAACCTCAGGTAGCTCCTGAAGATCTGTGCTTTCCAACAAGTGACTACCCTTGAAGCACATCCCCTTC
  81 TGGATCTGAAAAGAGCCCTTGGCTCAGGGCGTCTTTTTCCAGCCCCTGAGGAAATGGAATGAACCACTCCCTGCCCATTC
 161 CCTATAAGAATATCCCAAGACCCAGGCAATTTTGCCCCTCTTTCCCACATGCCCCCATATGTCTGAGCCAAACTGCACTG
 241 GGGGCTGCCCTCATGCCAAGCAAGAGCCTGGAATTCCCCTTCTTGATAATTCCATGGGAGACAGCAAACCCTTCTTTCCT
 321 TTGCCTGCCAGGAGCTTCACGACATTTGCAGATGGATGTCCTGCAACCCAAATGATCACATGTATCTATGGAAATCCAAA
 401 ATGCATCTGGGTGCAGCACTAAATAAATTCTCCATCCCTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacCUCUCUCUC----UCCGAGUCa 5'
             || | ||||     ||||||| 
Target 5' tctGA-AAAGAGCCCTTGGCTCAGg 3'
85 - 108 147.00 -17.30
2
miRNA  3' gaccucucucucuCCGAG-UCa 5'
                       ||||| || 
Target 5' -------------GGCTCTAGt 3'
1 - 9 108.00 -7.50
3
miRNA  3' gaccucucucucUCCGAGUCa 5'
                      :||: ||| 
Target 5' caaaatgcatctGGGTGCAGc 3'
397 - 417 93.00 -5.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30465489 13 COSMIC
COSN30455901 32 COSMIC
COSN20077446 35 COSMIC
COSN30486463 78 COSMIC
COSN30509498 83 COSMIC
COSN30130588 90 COSMIC
COSN15624906 94 COSMIC
COSN30148563 99 COSMIC
COSN31574698 103 COSMIC
COSN27664648 112 COSMIC
COSN30540598 123 COSMIC
COSN31558186 131 COSMIC
COSN28648270 136 COSMIC
COSN30486465 138 COSMIC
COSN15624907 152 COSMIC
COSN30134204 161 COSMIC
COSN8689674 183 COSMIC
COSN30135338 188 COSMIC
COSN30538762 226 COSMIC
COSN15624908 280 COSMIC
COSN15624909 283 COSMIC
COSN31550350 328 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs541030146 3 dbSNP
rs1276122373 4 dbSNP
rs771214608 5 dbSNP
rs776281446 8 dbSNP
rs759297230 14 dbSNP
rs1465531708 15 dbSNP
rs762680150 24 dbSNP
rs1018984784 30 dbSNP
rs758548579 30 dbSNP
rs2664 31 dbSNP
rs775121133 35 dbSNP
rs762594547 40 dbSNP
rs4245 41 dbSNP
rs1222134411 51 dbSNP
rs998771438 58 dbSNP
rs1222270107 61 dbSNP
rs191475060 73 dbSNP
rs879132170 74 dbSNP
rs2663 84 dbSNP
rs1018126841 90 dbSNP
rs1469449149 97 dbSNP
rs1023575937 98 dbSNP
rs1172838158 107 dbSNP
rs569767154 108 dbSNP
rs1197647328 109 dbSNP
rs760011008 111 dbSNP
rs113483326 112 dbSNP
rs1236044022 121 dbSNP
rs1182600609 125 dbSNP
rs1482862964 127 dbSNP
rs2665 136 dbSNP
rs1196284243 138 dbSNP
rs967487329 140 dbSNP
rs1290568988 148 dbSNP
rs560941810 151 dbSNP
rs1314027610 155 dbSNP
rs74818399 156 dbSNP
rs1196741584 157 dbSNP
rs1333617021 165 dbSNP
rs971700653 166 dbSNP
rs1475418068 175 dbSNP
rs1353958097 176 dbSNP
rs1169174826 180 dbSNP
rs1368266405 183 dbSNP
rs1407509308 188 dbSNP
rs920267769 192 dbSNP
rs926039042 200 dbSNP
rs958836084 202 dbSNP
rs535896998 210 dbSNP
rs991680083 213 dbSNP
rs930357645 215 dbSNP
rs1239663406 217 dbSNP
rs917492896 232 dbSNP
rs1480039226 239 dbSNP
rs950381269 248 dbSNP
rs1223683386 251 dbSNP
rs1449742794 253 dbSNP
rs1290932439 262 dbSNP
rs1240694229 266 dbSNP
rs760744941 299 dbSNP
rs764079159 301 dbSNP
rs1327538566 317 dbSNP
rs1229636300 328 dbSNP
rs1268537453 329 dbSNP
rs1438684946 333 dbSNP
rs944840773 341 dbSNP
rs867738508 342 dbSNP
rs183790886 351 dbSNP
rs1420745787 354 dbSNP
rs527771599 354 dbSNP
rs753918410 359 dbSNP
rs1292210563 364 dbSNP
rs929665089 374 dbSNP
rs1490762571 385 dbSNP
rs1048104875 387 dbSNP
rs572430237 389 dbSNP
rs546193325 390 dbSNP
rs1268148689 401 dbSNP
rs1006662041 406 dbSNP
rs1489164540 408 dbSNP
rs1283530470 409 dbSNP
rs998905847 412 dbSNP
rs1316612046 430 dbSNP
rs1302238846 431 dbSNP
rs1221054303 438 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccUCUCUCUCUCCGAGUCa 5'
              ||||     ||||||| 
Target 5' -aaaAGAGCCCUUGGCUCAGg 3'
1 - 20
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000528743.2 | 3UTR | AAAAGAGCCCUUGGCUCAGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

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