miRTarBase - #MIRT643446


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pre-miRNA Information
pre-miRNA hsa-mir-635   
Genomic Coordinates chr17: 68424451 - 68424548
Synonyms MIRN635, hsa-mir-635, MIR635
Description Homo sapiens miR-635 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-635
Sequence 16| ACUUGGGCACUGAAACAAUGUCC |38
Evidence Experimental
Experiments SAGE
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30524107 5 COSMIC
COSN492359 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1431386008 2 dbSNP
rs1200120170 6 dbSNP
rs1477452388 8 dbSNP
rs765045345 10 dbSNP
rs761495041 14 dbSNP
rs1447802278 18 dbSNP
rs994692593 18 dbSNP
rs776535164 23 dbSNP
Putative Targets

Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B0Q4NY miR-635 Predictive Biomarker (PRD) Transcriptomic Data . . . .
Gene Information
Gene Symbol LAX1   
Synonyms LAX
Description lymphocyte transmembrane adaptor 1
Transcript NM_001136190   
Other Transcripts NM_017773   
Expression
Putative miRNA Targets on LAX1
3'UTR of LAX1
(miRNA target sites are highlighted)		 
>LAX1|NM_001136190|3'UTR
   1 AGACCCAGGTACCCAGCCATAAAGCCACATTGAGTAGTCTATCCCATAGGATTGACTACTGCAGAGTCTAGTGCAGACCC
  81 GTGATCACCTTAGTGCTTCAGTGGATTCACTGGTTAGATTAAAAAGAGGCTGAGATGAGCAGTGAACTAAGAGGCCACAC
 161 AAAAGCAGAGGTTTGGGAATTCCAGAAGGGAATTCTTCTCAAGCAGAGTGTGGTTATCTCCTGTACCAGCCTAAGAATGT
 241 TTGCTGAAACTGCTTCCTAGAACTGTGAAGAAAGCAGGAAAGTAGTGCACAGTAGTCTAAGATTATTACCTTCATTAATA
 321 CCAACAGGCTGCAAAGCAAGAGTATAGATTATTGTATAATCCAGTCAGAGGTCAAAAGGAAGGAAGAAGTTGGAGTGGAG
 401 TGGGGTGGGCAATTTCCATTTTAAAGAGTGTAGGCAGGCCAGGTGCAGTGGCTCATGCCTGTAATCCCAGCATTTTGGTA
 481 GGCCGAGGAGGGCAGATCACTTGGTGCCAGGAGTTCTAGACCAGCCTGGCCAACATGACCCATCTTTACTAAAAATACAA
 561 AAATTAGCCAGGCGTGGTGGTGTGCCCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGAACCCGGG
 641 AGGTGGAGGTTGCAGCAAGCCGAGATTGTGCCACTGTACTCCAGCCTGGTGACAGAGCGAGACTCCCTCTCAAAAAAAAA
 721 AACAAACAAAAAAGAAGTGTGGGCAACCAAATGTAGGTAAGGATGAAGAAGAACAGGAACTCTCACTGGTGGCTGATGGG
 801 ATTGCAAAGCGTCAGGGCAGCTTTGAAAAACTTTTCAGCAGTTTCTTATAAGCATAACTTATCATATGGCCCAGCCATTT
 881 CACTACTAGAAATTGACGCAAGTGAACTGAAAACTTATGTTCACACAAAAACTCGCACATGACTGTTTATAGCAGCTTCA
 961 TTCATAATTACCAAAAACTAGAAATAACCCAGATATCCTTCAACAGGTGATTGGATAAGCTGTTGATATCCATTCCTTGA
1041 GTTTATCCATACTCAACAGTAAAAAATGAACTCTTGGTTCACACAATAATATAGACATATCTTAAATCCATTTTGCTAAG
1121 TGAAAGAAGCTAGGCCTAAAAGTCTACATGTTGGGCGATTCTATTTATATGACATTCTGGAAAAGGCAAAACTATAGGGA
1201 TGAAGAACAGATCAGTTGTTGTCAGGTTTGAGAAAAGGAGGGAAGTTTGCTACAAAGGGGCTGCAAAGGGAATAGGCTGA
1281 TGGAGCTGTTCTGTATGGTACTGTGTGGTGGATACATGACAATATCCATTTGCAAACACAAGAACTATACACATGGCCAG
1361 GCGCGGTGGCTCACACCCGTAATCCCAGCACTTTGCGGGGCCGAGGCAGGGGAACACAAGGTCAGGAGATCAAGACTGTC
1441 CTGGACAACATGGTGAAACCCTGTCTCTACTGTCTCTAACATTTGTAAACCTGTCTCTAATTTGTAATTTGTAAACCCTG
1521 TCTCTCATATTTGTAAAACTACAAAAATTAGCTTGGCATGGTGGTGTGCGCCTGTAGTCCCAGCTACTAGGAGGCTGAGG
1601 CAGGAGAATCACTTGAACCAGGAAGGCGGACTGCATTCCAGCCTGGGCAACAGAGAAAGACTCTGTCTCAAAAAAAAAAA
1681 AAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccuguaACAAAGUCACGGGUUCa 5'
                |||  ||  |||:||| 
Target 5' atctccTGTACCA--GCCTAAGa 3'
 216 - 236 133.00 -8.70
2 
miRNA  3' ccUGUAACA-AAGUCA-CGGGUUCa 5'
            | :| ||   |||| |:|:||| 
Target 5' gaAAGTAGTGCACAGTAGTCTAAGa 3'
 278 - 302 121.00 -11.80
3 
miRNA  3' ccUGUAACAAAGUCACGGGUUca 5'
            || || |  :|  |||||:  
Target 5' taAC-TTATCATATGGCCCAGcc 3'
 855 - 876 112.00 -8.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30153412 33 COSMIC
COSN30177813 93 COSMIC
COSN31507928 111 COSMIC
COSN30534132 150 COSMIC
COSN30121618 166 COSMIC
COSN20625385 240 COSMIC
COSN5736665 263 COSMIC
COSN21790104 444 COSMIC
COSN24103581 597 COSMIC
COSN24802284 699 COSMIC
COSN22449195 1380 COSMIC
COSN8969090 1385 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs762327821 3 dbSNP
rs767917448 4 dbSNP
rs749911662 5 dbSNP
rs755603110 7 dbSNP
rs779833013 8 dbSNP
rs1424845888 10 dbSNP
rs201124327 12 dbSNP
rs1187617655 17 dbSNP
rs979357356 20 dbSNP
rs376171819 21 dbSNP
rs754817096 29 dbSNP
rs1239655624 30 dbSNP
rs146967153 31 dbSNP
rs988011282 33 dbSNP
rs369197628 35 dbSNP
rs749081246 38 dbSNP
rs771977212 40 dbSNP
rs777601457 46 dbSNP
rs534298038 47 dbSNP
rs1318845643 53 dbSNP
rs918000429 56 dbSNP
rs949528152 71 dbSNP
rs1292475219 82 dbSNP
rs543825735 86 dbSNP
rs35620783 88 dbSNP
rs1231186784 105 dbSNP
rs1045052482 125 dbSNP
rs1381261605 127 dbSNP
rs569206573 131 dbSNP
rs1284654503 138 dbSNP
rs183615928 140 dbSNP
rs1352298310 156 dbSNP
rs1332761162 158 dbSNP
rs942265934 162 dbSNP
rs1270005072 165 dbSNP
rs1164663884 166 dbSNP
rs1422371974 170 dbSNP
rs551527214 181 dbSNP
rs144928231 193 dbSNP
rs369292080 193 dbSNP
rs1037922295 194 dbSNP
rs1470047361 210 dbSNP
rs1204377292 211 dbSNP
rs1231303191 219 dbSNP
rs1180536687 223 dbSNP
rs913088332 225 dbSNP
rs1447258735 227 dbSNP
rs1272710587 230 dbSNP
rs898124679 246 dbSNP
rs968427787 259 dbSNP
rs1323349622 265 dbSNP
rs1452930122 276 dbSNP
rs993620448 277 dbSNP
rs978516001 279 dbSNP
rs1371024915 284 dbSNP
rs1199143119 294 dbSNP
rs188406178 297 dbSNP
rs1051912714 316 dbSNP
rs890862569 317 dbSNP
rs1245553228 318 dbSNP
rs1479207767 320 dbSNP
rs1008412505 330 dbSNP
rs1184948260 333 dbSNP
rs1323547962 335 dbSNP
rs1017911717 346 dbSNP
rs899505431 347 dbSNP
rs1000744658 350 dbSNP
rs937020738 356 dbSNP
rs191616718 363 dbSNP
rs956641711 373 dbSNP
rs987958693 378 dbSNP
rs918164135 380 dbSNP
rs1440338373 388 dbSNP
rs1025250187 397 dbSNP
rs144881505 398 dbSNP
rs769361909 400 dbSNP
rs1393355109 402 dbSNP
rs970812191 406 dbSNP
rs1047863519 408 dbSNP
rs1214729937 419 dbSNP
rs1315091151 427 dbSNP
rs1288013779 432 dbSNP
rs1240759347 440 dbSNP
rs1346577194 443 dbSNP
rs1300619584 444 dbSNP
rs4951198 450 dbSNP
rs1378918621 455 dbSNP
rs1367796769 462 dbSNP
rs1343705975 464 dbSNP
rs1411800593 477 dbSNP
rs1294492988 478 dbSNP
rs1290108254 484 dbSNP
rs926608663 486 dbSNP
rs149045342 487 dbSNP
rs755974005 498 dbSNP
rs1420804844 502 dbSNP
rs1037746217 506 dbSNP
rs1173976063 514 dbSNP
rs1284168094 515 dbSNP
rs1435135718 517 dbSNP
rs143181094 536 dbSNP
rs575294166 537 dbSNP
rs973411738 538 dbSNP
rs148262633 539 dbSNP
rs1265023604 545 dbSNP
rs1217335320 556 dbSNP
rs1485296280 558 dbSNP
rs929584744 559 dbSNP
rs1234697770 564 dbSNP
rs1051916399 574 dbSNP
rs140394232 575 dbSNP
rs943769090 586 dbSNP
rs1212412775 591 dbSNP
rs1338951096 596 dbSNP
rs890354505 606 dbSNP
rs1290650580 607 dbSNP
rs1401162961 621 dbSNP
rs1039862988 628 dbSNP
rs1375307307 629 dbSNP
rs1010169662 636 dbSNP
rs899619461 638 dbSNP
rs761413242 639 dbSNP
rs1170060416 640 dbSNP
rs1032038521 644 dbSNP
rs34412467 649 dbSNP
rs978632184 650 dbSNP
rs1034095762 662 dbSNP
rs540538090 663 dbSNP
rs1009504318 672 dbSNP
rs1024778552 677 dbSNP
rs970972992 687 dbSNP
rs980672247 690 dbSNP
rs1473365173 698 dbSNP
rs560373742 699 dbSNP
rs529448132 700 dbSNP
rs1363992878 710 dbSNP
rs1441171727 712 dbSNP
rs751408243 712 dbSNP
rs983668384 712 dbSNP
rs79721099 713 dbSNP
rs942193090 714 dbSNP
rs12566161 719 dbSNP
rs57094739 719 dbSNP
rs147486513 720 dbSNP
rs201519369 720 dbSNP
rs973359501 722 dbSNP
rs1249230249 723 dbSNP
rs919278453 724 dbSNP
rs1176165645 728 dbSNP
rs1390679846 729 dbSNP
rs1038303048 732 dbSNP
rs1342026545 734 dbSNP
rs900565184 735 dbSNP
rs1245303010 742 dbSNP
rs1356142669 743 dbSNP
rs1247700504 744 dbSNP
rs1341532651 764 dbSNP
rs1313883159 774 dbSNP
rs1356773125 775 dbSNP
rs767231934 784 dbSNP
rs778490487 791 dbSNP
rs929532296 793 dbSNP
rs1379420061 799 dbSNP
rs1480064028 800 dbSNP
rs138040183 808 dbSNP
rs912025716 810 dbSNP
rs943530413 811 dbSNP
rs747505097 812 dbSNP
rs1363123711 818 dbSNP
rs866653152 819 dbSNP
rs879166091 821 dbSNP
rs1156331610 822 dbSNP
rs1020211526 830 dbSNP
rs1238222047 841 dbSNP
rs904475665 858 dbSNP
rs1183330377 859 dbSNP
rs921000709 863 dbSNP
rs936428454 877 dbSNP
rs1265723323 878 dbSNP
rs1383804770 883 dbSNP
rs538502841 886 dbSNP
rs1169476324 894 dbSNP
rs34200339 897 dbSNP
rs1285869489 898 dbSNP
rs6685890 899 dbSNP
rs553934490 904 dbSNP
rs892148046 933 dbSNP
rs531748545 935 dbSNP
rs1046744196 936 dbSNP
rs551831881 940 dbSNP
rs906487811 951 dbSNP
rs1325320949 958 dbSNP
rs1404314686 962 dbSNP
rs1002434989 963 dbSNP
rs1387089527 965 dbSNP
rs372417046 967 dbSNP
rs1383948260 969 dbSNP
rs1396566537 972 dbSNP
rs1421440459 988 dbSNP
rs1335779842 989 dbSNP
rs1033543220 992 dbSNP
rs571573582 999 dbSNP
rs1230070802 1004 dbSNP
rs1297952470 1006 dbSNP
rs1306391810 1007 dbSNP
rs527652049 1015 dbSNP
rs963407738 1021 dbSNP
rs994896477 1022 dbSNP
rs1023942569 1027 dbSNP
rs1201489773 1030 dbSNP
rs1452595072 1034 dbSNP
rs1262877450 1040 dbSNP
rs1257280432 1053 dbSNP
rs1215166169 1059 dbSNP
rs1489546801 1069 dbSNP
rs951046467 1083 dbSNP
rs1483838256 1093 dbSNP
rs1218684728 1094 dbSNP
rs12075158 1095 dbSNP
rs1026238724 1097 dbSNP
rs546928079 1098 dbSNP
rs950722370 1099 dbSNP
rs1276883723 1101 dbSNP
rs987528122 1118 dbSNP
rs912123091 1119 dbSNP
rs566728234 1137 dbSNP
rs965017699 1140 dbSNP
rs1401781274 1143 dbSNP
rs975297590 1145 dbSNP
rs1332966297 1149 dbSNP
rs926125515 1151 dbSNP
rs535747279 1155 dbSNP
rs770011153 1157 dbSNP
rs1053539275 1158 dbSNP
rs142024843 1166 dbSNP
rs1423421149 1170 dbSNP
rs1178275512 1173 dbSNP
rs146340279 1180 dbSNP
rs1264472773 1186 dbSNP
rs1470201903 1187 dbSNP
rs973572442 1196 dbSNP
rs1175622166 1215 dbSNP
rs77198318 1219 dbSNP
rs1046095370 1220 dbSNP
rs906426207 1221 dbSNP
rs1317462350 1233 dbSNP
rs1437071323 1242 dbSNP
rs1002147601 1243 dbSNP
rs1320777939 1246 dbSNP
rs1054856045 1254 dbSNP
rs899013009 1259 dbSNP
rs1360792440 1260 dbSNP
rs1341076669 1264 dbSNP
rs994842666 1265 dbSNP
rs1380193802 1270 dbSNP
rs932050164 1275 dbSNP
rs1026354172 1276 dbSNP
rs1341813179 1277 dbSNP
rs1312274612 1278 dbSNP
rs950836387 1280 dbSNP
rs74988844 1299 dbSNP
rs1223439036 1303 dbSNP
rs1397589306 1305 dbSNP
rs1261873700 1306 dbSNP
rs1169018392 1311 dbSNP
rs1331635044 1312 dbSNP
rs1018969468 1313 dbSNP
rs59804556 1314 dbSNP
rs765744538 1317 dbSNP
rs1472089261 1318 dbSNP
rs1239302011 1330 dbSNP
rs79558575 1331 dbSNP
rs926075062 1332 dbSNP
rs946023304 1333 dbSNP
rs544216669 1334 dbSNP
rs957526062 1339 dbSNP
rs1193150968 1342 dbSNP
rs753991472 1346 dbSNP
rs1288873617 1347 dbSNP
rs1041769754 1363 dbSNP
rs1358304638 1364 dbSNP
rs1284276357 1365 dbSNP
rs542326536 1366 dbSNP
rs760588168 1375 dbSNP
rs10900475 1376 dbSNP
rs1447059793 1379 dbSNP
rs894311063 1380 dbSNP
rs1427167245 1382 dbSNP
rs753593205 1386 dbSNP
rs1300137223 1387 dbSNP
rs1164319671 1394 dbSNP
rs373541894 1397 dbSNP
rs982162981 1398 dbSNP
rs1458370621 1401 dbSNP
rs927665405 1403 dbSNP
rs778571977 1404 dbSNP
rs1453284032 1411 dbSNP
rs1344405650 1418 dbSNP
rs1054968614 1419 dbSNP
rs1451097458 1422 dbSNP
rs1350958297 1423 dbSNP
rs899128001 1424 dbSNP
rs1310799638 1433 dbSNP
rs930469805 1439 dbSNP
rs752279161 1441 dbSNP
rs557900199 1449 dbSNP
rs1293341384 1451 dbSNP
rs779389939 1456 dbSNP
rs575668763 1460 dbSNP
rs968003470 1470 dbSNP
rs1304320779 1472 dbSNP
rs1009001077 1495 dbSNP
rs963567990 1497 dbSNP
rs1378608166 1514 dbSNP
rs1160467375 1515 dbSNP
rs1019332843 1517 dbSNP
rs1424672198 1520 dbSNP
rs1189675172 1521 dbSNP
rs11240418 1522 dbSNP
rs9792973 1540 dbSNP
rs953663975 1545 dbSNP
rs1229570646 1551 dbSNP
rs1287547840 1557 dbSNP
rs1283929845 1561 dbSNP
rs987696127 1562 dbSNP
rs1298800701 1565 dbSNP
rs777386513 1570 dbSNP
rs957639957 1571 dbSNP
rs149572629 1572 dbSNP
rs533682880 1573 dbSNP
rs1359106564 1578 dbSNP
rs1300147709 1603 dbSNP
rs1266311398 1605 dbSNP
rs1020484836 1607 dbSNP
rs1490198453 1612 dbSNP
rs966835499 1613 dbSNP
rs981893641 1616 dbSNP
rs1429757903 1618 dbSNP
rs144238057 1625 dbSNP
rs1476818359 1626 dbSNP
rs531906018 1628 dbSNP
rs545186530 1629 dbSNP
rs1482665570 1633 dbSNP
rs1253734728 1646 dbSNP
rs1406978355 1652 dbSNP
rs1312351739 1658 dbSNP
rs565342333 1660 dbSNP
rs1056122731 1661 dbSNP
rs1218357428 1661 dbSNP
rs920498439 1662 dbSNP
rs1417148305 1663 dbSNP
rs1166439581 1668 dbSNP
rs1339120821 1668 dbSNP
rs1280697494 1669 dbSNP
rs1378615754 1669 dbSNP
rs1383267647 1669 dbSNP
rs750543040 1669 dbSNP
rs775126412 1669 dbSNP
rs1193892969 1670 dbSNP
rs1196338102 1670 dbSNP
rs1237134952 1670 dbSNP
rs1253478768 1670 dbSNP
rs1407060681 1670 dbSNP
rs1423160751 1670 dbSNP
rs1425464195 1670 dbSNP
rs1463915175 1670 dbSNP
rs1467780103 1670 dbSNP
rs61192784 1670 dbSNP
rs768341425 1670 dbSNP
rs772033401 1670 dbSNP
rs778803558 1670 dbSNP
rs869071574 1670 dbSNP
rs1365848333 1677 dbSNP
rs1316517075 1682 dbSNP
rs894433700 1683 dbSNP
rs1228816929 1684 dbSNP
rs930585710 1685 dbSNP
rs1014488351 1686 dbSNP
rs1045571996 1688 dbSNP
rs1330981468 1688 dbSNP
rs1047530328 1689 dbSNP
rs1300687855 1689 dbSNP
rs886286931 1690 dbSNP
rs1443476787 1692 dbSNP
rs886831598 1692 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000442561.2 | 3UTR | CCAAGAGGUUGAGGCUGCAGUGAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.869 5.8e-5 -0.747 1.7e-3 13 Click to see details
GSE42095 Differentiated embryonic stem cells -0.417 2.4e-2 -0.255 1.2e-1 23 Click to see details
GSE38226 Liver fibrosis 0.363 5.3e-2 0.311 8.5e-2 21 Click to see details
GSE28544 Breast cancer -0.309 7.1e-2 -0.454 1.3e-2 24 Click to see details
GSE26953 Aortic valvular endothelial cells 0.27 1.0e-1 -0.013 4.8e-1 24 Click to see details
GSE21849 B cell lymphoma 0.201 1.5e-1 0.210 1.4e-1 29 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.211 1.6e-1 -0.302 7.1e-2 25 Click to see details
GSE17498 Multiple myeloma 0.159 1.6e-1 0.130 2.1e-1 40 Click to see details
GSE32688 Pancreatic cancer 0.169 1.8e-1 0.196 1.4e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.16 2.5e-1 0.432 2.9e-2 20 Click to see details
GSE27834 Pluripotent stem cells -0.092 3.7e-1 0.056 4.2e-1 16 Click to see details
GSE14794 Lymphoblastoid cells -0.014 4.5e-1 0.043 3.4e-1 90 Click to see details
GSE17306 Multiple myeloma 0.017 4.5e-1 0.468 3.5e-4 49 Click to see details
GSE21687 Ependynoma primary tumors -0.013 4.6e-1 -0.027 4.2e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.013 4.6e-1 -0.027 4.2e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.013 4.6e-1 -0.027 4.2e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
48 hsa-miR-635 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055249 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT150167 MIDN midnolin 2 2
MIRT198486 USP14 ubiquitin specific peptidase 14 2 6
MIRT446204 GTPBP4 GTP binding protein 4 2 2
MIRT453083 SUMF2 sulfatase modifying factor 2 2 6
MIRT462505 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 8
MIRT474413 KLHL28 kelch like family member 28 2 8
MIRT479376 CELF1 CUGBP Elav-like family member 1 2 4
MIRT498090 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT525565 MTRNR2L7 MT-RNR2-like 7 2 6
MIRT525613 MTRNR2L3 MT-RNR2-like 3 2 4
MIRT531868 POF1B premature ovarian failure, 1B 2 2
MIRT535789 MTRNR2L11 MT-RNR2-like 11 2 6
MIRT535807 MTRNR2L10 MT-RNR2-like 10 2 4
MIRT539940 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT563194 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 2
MIRT563803 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 2
MIRT576360 Pxdn peroxidasin 2 2
MIRT615575 NCS1 neuronal calcium sensor 1 2 2
MIRT620858 SERPING1 serpin family G member 1 2 2
MIRT623189 NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 2 2
MIRT625116 SLC1A5 solute carrier family 1 member 5 2 2
MIRT625128 NUP93 nucleoporin 93 2 2
MIRT625904 LINC00632 long intergenic non-protein coding RNA 632 2 2
MIRT626820 PRR11 proline rich 11 2 2
MIRT628142 HM13 histocompatibility minor 13 2 2
MIRT633789 ZNF490 zinc finger protein 490 2 2
MIRT634385 RAP2B RAP2B, member of RAS oncogene family 2 2
MIRT636563 EPB41 erythrocyte membrane protein band 4.1 2 2
MIRT643446 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT646006 HTRA1 HtrA serine peptidase 1 2 2
MIRT652141 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT652672 TIMELESS timeless circadian clock 2 2
MIRT658341 FAM83D family with sequence similarity 83 member D 2 2
MIRT658890 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT659518 CHST3 carbohydrate sulfotransferase 3 2 2
MIRT668590 ELAVL3 ELAV like RNA binding protein 3 2 2
MIRT670258 ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2 2
MIRT686721 TBC1D13 TBC1 domain family member 13 2 2
MIRT701899 MNT MAX network transcriptional repressor 2 2
MIRT702764 IGF1R insulin like growth factor 1 receptor 2 2
MIRT705290 B4GALT1 beta-1,4-galactosyltransferase 1 2 2
MIRT710836 BASP1 brain abundant membrane attached signal protein 1 2 2
MIRT711732 NUPL2 nucleoporin like 2 2 2
MIRT717619 SLC30A10 solute carrier family 30 member 10 2 2
MIRT719453 APBA1 amyloid beta precursor protein binding family A member 1 2 2
MIRT720819 CIAO1 cytosolic iron-sulfur assembly component 1 2 2
MIRT723454 CUL4A cullin 4A 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-635 Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-635 Cisplatin 5460033 NSC119875 approved resistant cell line
hsa-miR-635 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM36)
hsa-miR-635 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-635 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM47)
hsa-miR-635 Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-635 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-635 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)

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