miRTarBase - #MIRT643508


—
pre-miRNA Information
pre-miRNA hsa-mir-3911   
Genomic Coordinates chr9: 127690687 - 127690795
Description Homo sapiens miR-3911 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3911
Sequence 12| UGUGUGGAUCCUGGAGGAGGCA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
431152 7 ClinVar
COSM3847691 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs943029638 2 dbSNP
rs780635543 3 dbSNP
rs371437556 6 dbSNP
rs1135401819 7 dbSNP
rs748706130 14 dbSNP
rs1403241180 15 dbSNP
rs779344153 17 dbSNP
rs755366929 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF28   
Synonyms KOX24
Description zinc finger protein 28
Transcript NM_006969   
Expression
Putative miRNA Targets on ZNF28
3'UTR of ZNF28
(miRNA target sites are highlighted)		 
>ZNF28|NM_006969|3'UTR
   1 AAGTGTAATGAGTGTGGCAAGACCTTCAGTCAGATGTCAAACCTTGTATACCATCATAGACTTCATAGTGGAGAGAAACC
  81 TTAAAAGTGTAATGAGTGTGGCAACACCTTCCATCACAATTCAACCCTTGTAAGTCACAAAGCCATTCATACTGGAGAGA
 161 AACTTTACAAGTGTAATGAATGTGGCAAGGTTTTTAATCAAAAAACAACCCTTGCACGTCATCATAGAATTCATACTGCA
 241 GAGAAACTTTACAAATAGGAAGAATGTGACAAAGTTTTCGGTTGCAAATCAAACCTTGAAACACATAAGAAAATGCATGC
 321 TGAAGAGAAACCACACAGATGTAAGGTTTATGACAAGATTTTTGAATATAATTCATACCTGGCAAAACATATTAGAATTC
 401 AAACTGGAGAGAAACCTTACAAATGTGATGAGTGTGGCAACACCTTTGGTCAAAATTCATACCTTGTAATTCAAAAGGCA
 481 ATTCGTATTGGAGAGAAACCCTACAAGTGTAATGAATGTGGCATAGTTTTTAATCAACAGTCACACCTTGCAAGTCATCA
 561 TAGTCTTCATACTGCAGAGAAATCTTACAAATGTGAAGACTGTGACAAAGTTGTCAGTCACAAATCACAGCTTGAAAGAC
 641 AGGAGAATTCATACTGGAGAAAAAACATACAAATGTAAGGTTTGTAACAAGGCTTTTGGGAGTGATTCACACCTGGCACA
 721 CCATACTAGAATTCACACTGGAGAGAAACCTTACAAGTGCAATGAGTGTGGCAAAGCCTTTAGTGGGCAGTCACCACTTA
 801 TTCACCATCAAGCAATCCATAGTATAGGGAAACTTGACTAATATAATGATTGTCACAAAGTTTTCAGTAATGCTACAACC
 881 ATTGCAAATCATTGGAGAATCCATAATGAGAGATCTTACAAGTGTAATAAATGTGACAGATTTTTCAGATATCGTTCATA
 961 TATTGCTATTCATCATCGAACTCATGCTGGAGAGAAACCTTATAAATGTCATGATTGTGGCAAGGTCTTCAGTCAAGTTT
1041 CATCCTATGCAAAACATAGGAGGATTCATACAGGAGAGAAACTCACAAGTGTGATGATTGTGGCAAAGCGTTTACTTCAC
1121 ATTCACACCTCAATAGACATCAGAGAATCCATGCTGGACAGAAATCTTACAAATGTCATCAGTGTGGTAAGGTCTTCAGT
1201 CCGAGATCACTCCTTGCAGACCATCAGACAATTCCTTTTGGAGACAGTTGTTTCAAATGCCATTAGTATAGCAAGCCATC
1281 AAGCATTAATTGACATTACAGTTAAATGAGCACTGACCTGAGTTTGAGTTGACTTAACATTGAGTTTAAGCATTAATTGA
1361 CATTAAACTGTTTATGTTAAGAGGACTGGGCTGGGCACTGTGGCTCACGCCTGCAATGCCAGCACTTTGAGAGGCCAAGA
1441 CTGGTAGGTCACTGGAGGTTAAGAGTTTGAGAACAGCCTGGCCAACAGACGGGAGCCACTTTTCCCAGCCTGTGTTTTCA
1521 TTTCTATTCTTTCTTTCTTTTTTCTTTTTTTTGTTTTTGTTTTTGAGATGGAGTCTCTTGCTCTGTCATCCAGGTTGGAG
1601 TGCAGTGGCATGATCTTGACTCACTACAACCTCCGCCTCCCAGGTTCAAGCGATCCTCCTGCCTCAGTCTCCTGACTAGC
1681 TGGGACTACAGGTGCATGCCACCACACCTGGATAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCGCTGTGTTAGCCTG
1761 GATGGTCTCGATTTTCTGATCTTATGATTCACCCACCTCTACCTCCCGAAGTGCTGAGATTATGGGCGTGAGCCACCGTG
1841 ACTGGCCTGTTTTTTGTTTCTTTAACAAAAAGTTATGGGGATTTCTATGAGTATTGTGTTGAATCTAAATCACATTCGGT
1921 TATATAATCATTGAGCAATACTAATTTTTCCAATCAGTATGGATTGTATGTGTATTTATATGTTTTTAATCATTTTGATC
2001 AATGTTTGTAGATTTCAAGGTACAAACTTCTCACCTTTATATGTTTATTCCTAAATATTTCTTACTTTAAGCTCTTTAGC
2081 AAATGGAAGTGGTTTTTAATTTTATTTTAAAATTATTTAATGTTAATGTATGGAAATTCAACTAATTTTTGGTGCTATTA
2161 TTCTATTCTGCAAATACACTGAATATGTTTATTAGTTCCAGTTGTATTTTGGTTGACTGTGATTTTCTTCACAGATCATG
2241 TCATCTACAAACAAATAAAATTTGACTTCTTTCTTTCTGAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acgGAGG-A-GGUCCUAGGUGUGu 5'
             | || | |:|| ||:||||| 
Target 5' gcaCACCATACTAGAATTCACACt 3'
 716 - 739 143.00 -14.50
2 
miRNA  3' acGGAGGAGGUCCUAGGUGUGu 5'
            ::| ||:||  ||:||||| 
Target 5' cgTTTACTTCA-CATTCACACc 3'
 1109 - 1129 143.00 -13.50
3 
miRNA  3' acGGAGGAGGUC-CUAGGUGUGu 5'
            |:|::   || |||:||||| 
Target 5' ggCTTTTGGGAGTGATTCACACc 3'
 691 - 713 140.00 -17.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30535614 6 COSMIC
COSN31529152 17 COSMIC
COSN30490835 33 COSMIC
COSN31500841 33 COSMIC
COSN30463252 36 COSMIC
COSN30527553 43 COSMIC
COSN30519732 47 COSMIC
COSN18742133 59 COSMIC
COSN30167878 73 COSMIC
COSN31610230 78 COSMIC
COSN15619146 83 COSMIC
COSN32055675 87 COSMIC
COSN30451360 107 COSMIC
COSN31482549 115 COSMIC
COSN28813995 124 COSMIC
COSN30169190 143 COSMIC
COSN31614246 150 COSMIC
COSN27030745 164 COSMIC
COSN30157555 168 COSMIC
COSN2382197 177 COSMIC
COSN1082450 179 COSMIC
COSN30519724 195 COSMIC
COSN13825768 199 COSMIC
COSN30516734 203 COSMIC
COSN30104073 238 COSMIC
COSN30116516 238 COSMIC
COSN1082451 264 COSMIC
COSN2382198 279 COSMIC
COSN30134403 281 COSMIC
COSN31564522 321 COSMIC
COSN30152728 322 COSMIC
COSN30119983 368 COSMIC
COSN30176951 395 COSMIC
COSN30177187 400 COSMIC
COSN26101917 422 COSMIC
COSN1218195 427 COSMIC
COSN30177115 451 COSMIC
COSN1082452 484 COSMIC
COSN31518824 497 COSMIC
COSN31508152 543 COSMIC
COSN30157195 584 COSMIC
COSN30126118 626 COSMIC
COSN31519236 645 COSMIC
COSN31610365 659 COSMIC
COSN1082454 668 COSMIC
COSN30494145 680 COSMIC
COSN21877184 687 COSMIC
COSN1082455 729 COSMIC
COSN30476586 729 COSMIC
COSN30105690 760 COSMIC
COSN30179089 764 COSMIC
COSN30533675 794 COSMIC
COSN30488247 795 COSMIC
COSN30506402 811 COSMIC
COSN30190771 812 COSMIC
COSN5439226 814 COSMIC
COSN30461456 821 COSMIC
COSN30165821 829 COSMIC
COSN31502646 834 COSMIC
COSN30130894 859 COSMIC
COSN30507866 865 COSMIC
COSN30527301 866 COSMIC
COSN31614077 867 COSMIC
COSN32064852 884 COSMIC
COSN31485919 897 COSMIC
COSN31489971 897 COSMIC
COSN30503885 914 COSMIC
COSN1082456 939 COSMIC
COSN31544236 971 COSMIC
COSN13825745 978 COSMIC
COSN31610825 1017 COSMIC
COSN20116035 1058 COSMIC
COSN31523811 1101 COSMIC
COSN15668342 1145 COSMIC
COSN28745688 1146 COSMIC
COSN8606274 1146 COSMIC
COSN28816398 1153 COSMIC
COSN30492408 1167 COSMIC
COSN30125788 1197 COSMIC
COSN30506298 1203 COSMIC
COSN30447419 1212 COSMIC
COSN30125101 1235 COSMIC
COSN30140308 1256 COSMIC
COSN19663230 1264 COSMIC
COSN1771291 1270 COSMIC
COSN30111806 1316 COSMIC
COSN6146841 1376 COSMIC
COSN28785185 1396 COSMIC
COSN30132877 1407 COSMIC
COSN30132878 1408 COSMIC
COSN29371806 1647 COSMIC
COSN6146840 1653 COSMIC
COSN1771290 1825 COSMIC
COSN31523831 1996 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs771973805 3 dbSNP
rs965613211 3 dbSNP
rs549512525 10 dbSNP
rs1285410359 12 dbSNP
rs746221109 13 dbSNP
rs574153174 14 dbSNP
rs757726235 18 dbSNP
rs1431506890 20 dbSNP
rs1204563284 21 dbSNP
rs1249650170 24 dbSNP
rs1471574415 27 dbSNP
rs1019421535 29 dbSNP
rs9917046 42 dbSNP
rs748018802 43 dbSNP
rs563827798 46 dbSNP
rs371999424 47 dbSNP
rs754528005 51 dbSNP
rs776937386 53 dbSNP
rs1367096814 61 dbSNP
rs995211777 70 dbSNP
rs1306897371 77 dbSNP
rs1368103026 78 dbSNP
rs1444999054 79 dbSNP
rs1280714862 84 dbSNP
rs894138384 89 dbSNP
rs921817418 94 dbSNP
rs1317560928 96 dbSNP
rs1360460001 103 dbSNP
rs1055980361 104 dbSNP
rs545527335 107 dbSNP
rs527857810 112 dbSNP
rs1040219661 113 dbSNP
rs1439699373 114 dbSNP
rs938425898 119 dbSNP
rs1233433646 126 dbSNP
rs1482869428 142 dbSNP
rs1226469083 152 dbSNP
rs1349851781 164 dbSNP
rs1386808196 168 dbSNP
rs907381725 170 dbSNP
rs150346798 173 dbSNP
rs1411433021 175 dbSNP
rs542469740 177 dbSNP
rs1411213712 180 dbSNP
rs10410012 204 dbSNP
rs1359123585 211 dbSNP
rs115119333 215 dbSNP
rs932014998 216 dbSNP
rs544610019 217 dbSNP
rs371465484 218 dbSNP
rs970307679 221 dbSNP
rs966127502 223 dbSNP
rs559075349 229 dbSNP
rs1411962880 230 dbSNP
rs185550273 242 dbSNP
rs1439933619 244 dbSNP
rs142480960 246 dbSNP
rs1332547261 250 dbSNP
rs1244755716 252 dbSNP
rs1014445005 253 dbSNP
rs982598287 256 dbSNP
rs951191785 258 dbSNP
rs1026937265 259 dbSNP
rs138371643 263 dbSNP
rs1168011904 264 dbSNP
rs772519831 269 dbSNP
rs1423781232 272 dbSNP
rs1005075075 279 dbSNP
rs745362004 280 dbSNP
rs1003048215 281 dbSNP
rs1048716183 289 dbSNP
rs192672365 302 dbSNP
rs1431694026 305 dbSNP
rs1274351717 306 dbSNP
rs1342879741 312 dbSNP
rs906915740 314 dbSNP
rs1225428901 316 dbSNP
rs575039843 317 dbSNP
rs10408156 319 dbSNP
rs1328306839 332 dbSNP
rs1288922073 338 dbSNP
rs866671653 339 dbSNP
rs1281818927 343 dbSNP
rs900446086 345 dbSNP
rs550088835 363 dbSNP
rs1010397677 364 dbSNP
rs944625614 376 dbSNP
rs913089036 378 dbSNP
rs147045862 382 dbSNP
rs1430660453 391 dbSNP
rs1457141164 392 dbSNP
rs778223421 393 dbSNP
rs1403249133 395 dbSNP
rs756931305 395 dbSNP
rs1338774468 405 dbSNP
rs186504807 414 dbSNP
rs1388477133 420 dbSNP
rs1160582322 423 dbSNP
rs1471339189 427 dbSNP
rs932214461 436 dbSNP
rs1283971683 438 dbSNP
rs1346094738 439 dbSNP
rs921941705 444 dbSNP
rs538279572 448 dbSNP
rs925991489 449 dbSNP
rs527395218 452 dbSNP
rs944790821 454 dbSNP
rs1244668011 456 dbSNP
rs10407539 460 dbSNP
rs548496427 462 dbSNP
rs1464063860 463 dbSNP
rs1268640038 465 dbSNP
rs546844401 467 dbSNP
rs752505634 472 dbSNP
rs34964374 477 dbSNP
rs1472559764 481 dbSNP
rs1180203191 484 dbSNP
rs530359938 485 dbSNP
rs10407516 488 dbSNP
rs917240986 491 dbSNP
rs993516619 493 dbSNP
rs961642949 494 dbSNP
rs1341224772 495 dbSNP
rs1304858270 498 dbSNP
rs1337441146 532 dbSNP
rs754916802 533 dbSNP
rs1283340773 539 dbSNP
rs1356854640 540 dbSNP
rs1317446752 543 dbSNP
rs1432927423 554 dbSNP
rs796929502 556 dbSNP
rs534203181 565 dbSNP
rs1193560797 569 dbSNP
rs567413726 570 dbSNP
rs1438870450 575 dbSNP
rs1321352186 588 dbSNP
rs1187324981 590 dbSNP
rs1402934404 593 dbSNP
rs771639095 605 dbSNP
rs1163042118 609 dbSNP
rs958581657 611 dbSNP
rs1458744760 612 dbSNP
rs141562216 616 dbSNP
rs577279518 621 dbSNP
rs1389764184 623 dbSNP
rs1460573250 629 dbSNP
rs750465534 631 dbSNP
rs1391845750 641 dbSNP
rs1186310652 643 dbSNP
rs1335857259 646 dbSNP
rs1380220805 654 dbSNP
rs754009020 657 dbSNP
rs1454373454 666 dbSNP
rs1448539195 667 dbSNP
rs1340997071 672 dbSNP
rs183636509 677 dbSNP
rs540693916 679 dbSNP
rs191565995 684 dbSNP
rs1194772319 688 dbSNP
rs113544382 689 dbSNP
rs893326384 693 dbSNP
rs1241826501 710 dbSNP
rs1266593019 713 dbSNP
rs1184567565 716 dbSNP
rs1247685825 717 dbSNP
rs1210157105 720 dbSNP
rs1033114309 723 dbSNP
rs1361359708 734 dbSNP
rs1172649294 739 dbSNP
rs996394027 745 dbSNP
rs1373661672 752 dbSNP
rs1462439864 754 dbSNP
rs1175704732 755 dbSNP
rs73936419 762 dbSNP
rs1041025667 783 dbSNP
rs574610296 815 dbSNP
rs891668452 818 dbSNP
rs879077424 822 dbSNP
rs556018148 824 dbSNP
rs1380123910 827 dbSNP
rs765329644 828 dbSNP
rs1433068660 836 dbSNP
rs886426820 836 dbSNP
rs1047866221 844 dbSNP
rs1261864057 848 dbSNP
rs764310945 852 dbSNP
rs183378789 855 dbSNP
rs1204746423 868 dbSNP
rs1267841364 873 dbSNP
rs1485023057 875 dbSNP
rs1044525555 878 dbSNP
rs142460682 880 dbSNP
rs7248697 884 dbSNP
rs1197336837 887 dbSNP
rs533588277 893 dbSNP
rs1470894959 904 dbSNP
rs756491252 910 dbSNP
rs149207502 914 dbSNP
rs1451351055 915 dbSNP
rs548298374 916 dbSNP
rs971112596 917 dbSNP
rs1385194104 920 dbSNP
rs530208129 952 dbSNP
rs375226510 953 dbSNP
rs551258904 954 dbSNP
rs988534427 959 dbSNP
rs1306742927 972 dbSNP
rs957085542 975 dbSNP
rs1199529957 977 dbSNP
rs1490831944 978 dbSNP
rs1261584112 980 dbSNP
rs1488263137 984 dbSNP
rs1033143974 986 dbSNP
rs1271082768 989 dbSNP
rs1028434610 993 dbSNP
rs1200138641 1003 dbSNP
rs996341546 1003 dbSNP
rs1407143449 1008 dbSNP
rs974497863 1010 dbSNP
rs964488718 1011 dbSNP
rs1423553016 1012 dbSNP
rs1300759720 1013 dbSNP
rs900660556 1018 dbSNP
rs1405026252 1028 dbSNP
rs1298165963 1033 dbSNP
rs1204255369 1036 dbSNP
rs1371784869 1041 dbSNP
rs1019223827 1043 dbSNP
rs867660300 1045 dbSNP
rs1482851790 1046 dbSNP
rs1019026446 1057 dbSNP
rs1009544633 1061 dbSNP
rs1294051718 1062 dbSNP
rs1490549970 1063 dbSNP
rs34599433 1065 dbSNP
rs56327714 1065 dbSNP
rs1232270241 1069 dbSNP
rs886460334 1074 dbSNP
rs202072929 1075 dbSNP
rs1178749714 1082 dbSNP
rs1047731482 1086 dbSNP
rs1342995572 1087 dbSNP
rs1274375261 1089 dbSNP
rs1224636455 1091 dbSNP
rs1347995910 1093 dbSNP
rs1161356651 1109 dbSNP
rs371207217 1110 dbSNP
rs1424803952 1113 dbSNP
rs192896534 1122 dbSNP
rs1169098955 1124 dbSNP
rs1031571182 1126 dbSNP
rs1000097013 1132 dbSNP
rs7253764 1133 dbSNP
rs1055210832 1134 dbSNP
rs1173617406 1135 dbSNP
rs1370728073 1137 dbSNP
rs1330502873 1138 dbSNP
rs754519999 1147 dbSNP
rs937221602 1148 dbSNP
rs1270907341 1153 dbSNP
rs1305705731 1154 dbSNP
rs927104174 1160 dbSNP
rs1238707272 1163 dbSNP
rs1460751745 1164 dbSNP
rs1181503140 1169 dbSNP
rs12971480 1170 dbSNP
rs1172706358 1171 dbSNP
rs1481371259 1175 dbSNP
rs188815456 1177 dbSNP
rs1416699792 1188 dbSNP
rs1409756338 1202 dbSNP
rs1181111072 1203 dbSNP
rs1472805563 1209 dbSNP
rs561212118 1212 dbSNP
rs1405961515 1230 dbSNP
rs1057443892 1235 dbSNP
rs1233623574 1241 dbSNP
rs1383826991 1243 dbSNP
rs1206847341 1245 dbSNP
rs1268497520 1247 dbSNP
rs1364254580 1250 dbSNP
rs1215227047 1253 dbSNP
rs1258688039 1254 dbSNP
rs1440955255 1260 dbSNP
rs17770620 1264 dbSNP
rs574518866 1268 dbSNP
rs555950335 1269 dbSNP
rs1287016611 1272 dbSNP
rs1228117349 1275 dbSNP
rs1191948508 1276 dbSNP
rs931556905 1285 dbSNP
rs957033727 1294 dbSNP
rs144398880 1302 dbSNP
rs974451764 1306 dbSNP
rs1281684645 1318 dbSNP
rs1429236161 1322 dbSNP
rs759994858 1326 dbSNP
rs1479713191 1332 dbSNP
rs964931247 1333 dbSNP
rs1179047022 1336 dbSNP
rs576722249 1337 dbSNP
rs1407212198 1338 dbSNP
rs1400485608 1339 dbSNP
rs1316572778 1340 dbSNP
rs1019506300 1342 dbSNP
rs975511048 1343 dbSNP
rs964824351 1344 dbSNP
rs558462115 1354 dbSNP
rs1282681723 1358 dbSNP
rs1344830462 1361 dbSNP
rs1009164808 1366 dbSNP
rs1284966814 1370 dbSNP
rs1345540512 1371 dbSNP
rs1204323519 1373 dbSNP
rs987562938 1374 dbSNP
rs56677415 1376 dbSNP
rs1216729598 1378 dbSNP
rs1267481182 1395 dbSNP
rs773933520 1402 dbSNP
rs566489356 1408 dbSNP
rs1358280237 1419 dbSNP
rs1031330934 1420 dbSNP
rs554337044 1425 dbSNP
rs1000150928 1434 dbSNP
rs1026319419 1441 dbSNP
rs1022807870 1445 dbSNP
rs1410480984 1448 dbSNP
rs1012718906 1463 dbSNP
rs895902030 1464 dbSNP
rs1302647380 1471 dbSNP
rs536359745 1490 dbSNP
rs1406846020 1491 dbSNP
rs1386296706 1492 dbSNP
rs899154928 1493 dbSNP
rs1238094451 1496 dbSNP
rs1277504484 1497 dbSNP
rs1352409863 1509 dbSNP
rs569437224 1510 dbSNP
rs1290572114 1512 dbSNP
rs1489671569 1513 dbSNP
rs866658953 1518 dbSNP
rs1002678474 1521 dbSNP
rs759047797 1524 dbSNP
rs201156682 1526 dbSNP
rs1045941076 1529 dbSNP
rs1179955469 1536 dbSNP
rs1471929722 1537 dbSNP
rs1180138632 1539 dbSNP
rs1237122604 1541 dbSNP
rs139235025 1544 dbSNP
rs887143112 1544 dbSNP
rs1383608063 1549 dbSNP
rs1163868041 1551 dbSNP
rs1462728516 1551 dbSNP
rs1048378465 1553 dbSNP
rs1390688072 1554 dbSNP
rs931566481 1568 dbSNP
rs921479918 1570 dbSNP
rs913191293 1571 dbSNP
rs1039859408 1573 dbSNP
rs1052960168 1574 dbSNP
rs1447228124 1575 dbSNP
rs1356786598 1585 dbSNP
rs1247575608 1587 dbSNP
rs944194572 1588 dbSNP
rs183245087 1590 dbSNP
rs1286768223 1592 dbSNP
rs1275720267 1593 dbSNP
rs770581894 1602 dbSNP
rs1458541880 1604 dbSNP
rs987268490 1605 dbSNP
rs748866709 1609 dbSNP
rs955977084 1620 dbSNP
rs571963145 1634 dbSNP
rs370155873 1635 dbSNP
rs1460523740 1637 dbSNP
rs912071109 1644 dbSNP
rs377407384 1651 dbSNP
rs1319355541 1652 dbSNP
rs1465981768 1665 dbSNP
rs988005215 1666 dbSNP
rs776171714 1675 dbSNP
rs769375075 1676 dbSNP
rs1397359788 1679 dbSNP
rs528455142 1680 dbSNP
rs1312818116 1691 dbSNP
rs561356858 1695 dbSNP
rs7253090 1696 dbSNP
rs531037616 1697 dbSNP
rs1164485658 1698 dbSNP
rs963393940 1704 dbSNP
rs563486875 1706 dbSNP
rs1022860427 1709 dbSNP
rs1246243316 1712 dbSNP
rs1188073080 1730 dbSNP
rs1033653772 1736 dbSNP
rs1486478970 1738 dbSNP
rs543992570 1741 dbSNP
rs1002303267 1742 dbSNP
rs7252051 1747 dbSNP
rs751452337 1749 dbSNP
rs895414450 1750 dbSNP
rs778904306 1752 dbSNP
rs558406597 1759 dbSNP
rs1403548313 1760 dbSNP
rs1339701998 1761 dbSNP
rs887151393 1769 dbSNP
rs757313770 1770 dbSNP
rs540540751 1772 dbSNP
rs1380070364 1785 dbSNP
rs370707293 1793 dbSNP
rs935898213 1795 dbSNP
rs139464671 1796 dbSNP
rs900109816 1797 dbSNP
rs1234392349 1801 dbSNP
rs554556500 1803 dbSNP
rs944275566 1807 dbSNP
rs943135455 1808 dbSNP
rs891331144 1813 dbSNP
rs150498131 1819 dbSNP
rs568973310 1823 dbSNP
rs557136467 1824 dbSNP
rs1365931380 1825 dbSNP
rs539221527 1827 dbSNP
rs375508184 1828 dbSNP
rs1388624780 1829 dbSNP
rs1169750891 1832 dbSNP
rs1451097721 1834 dbSNP
rs191039153 1836 dbSNP
rs1422215780 1837 dbSNP
rs1403783492 1838 dbSNP
rs1190017147 1845 dbSNP
rs1301888157 1860 dbSNP
rs1488466191 1862 dbSNP
rs978437823 1863 dbSNP
rs919404709 1871 dbSNP
rs764268249 1875 dbSNP
rs1481829108 1879 dbSNP
rs546951258 1887 dbSNP
rs113296076 1888 dbSNP
rs1308780235 1889 dbSNP
rs981221963 1896 dbSNP
rs369832055 1909 dbSNP
rs760830097 1917 dbSNP
rs117793261 1918 dbSNP
rs753066274 1919 dbSNP
rs1218552289 1926 dbSNP
rs748046154 1932 dbSNP
rs891649786 1934 dbSNP
rs1423494583 1940 dbSNP
rs375543862 1953 dbSNP
rs1352144361 1956 dbSNP
rs9917029 1957 dbSNP
rs951476120 1959 dbSNP
rs1371717009 1960 dbSNP
rs1449452652 1966 dbSNP
rs1310330327 1967 dbSNP
rs1382274946 1968 dbSNP
rs1243913979 1972 dbSNP
rs1292060982 1974 dbSNP
rs1323449531 1981 dbSNP
rs1407773340 1982 dbSNP
rs530850109 1989 dbSNP
rs1297846720 1991 dbSNP
rs185195741 1991 dbSNP
rs1000077423 1994 dbSNP
rs1356328026 2003 dbSNP
rs899874257 2004 dbSNP
rs1174114878 2006 dbSNP
rs563424183 2008 dbSNP
rs1480392248 2010 dbSNP
rs1008521572 2012 dbSNP
rs904408649 2019 dbSNP
rs1038947203 2023 dbSNP
rs1332401299 2025 dbSNP
rs545124119 2027 dbSNP
rs1405661338 2032 dbSNP
rs1430612058 2034 dbSNP
rs943062254 2039 dbSNP
rs1380068697 2040 dbSNP
rs1214031733 2053 dbSNP
rs1294833415 2064 dbSNP
rs890113322 2065 dbSNP
rs1200342253 2068 dbSNP
rs533282046 2068 dbSNP
rs371960820 2085 dbSNP
rs1249333361 2089 dbSNP
rs1051971070 2097 dbSNP
rs55751085 2098 dbSNP
rs929014385 2103 dbSNP
rs532145937 2115 dbSNP
rs1253729259 2120 dbSNP
rs1208898517 2121 dbSNP
rs1207657294 2128 dbSNP
rs1324104408 2130 dbSNP
rs1285133939 2139 dbSNP
rs1185405861 2141 dbSNP
rs935458511 2154 dbSNP
rs371329594 2157 dbSNP
rs1479064160 2158 dbSNP
rs367553417 2160 dbSNP
rs1171831866 2163 dbSNP
rs1349686404 2163 dbSNP
rs942175210 2164 dbSNP
rs926903786 2165 dbSNP
rs1042855345 2173 dbSNP
rs1307496924 2182 dbSNP
rs1336448358 2183 dbSNP
rs1392163046 2191 dbSNP
rs981034103 2194 dbSNP
rs947111447 2202 dbSNP
rs971160798 2203 dbSNP
rs1287151717 2206 dbSNP
rs60516234 2211 dbSNP
rs182339347 2212 dbSNP
rs1278749170 2222 dbSNP
rs3087598 2224 dbSNP
rs1280357061 2230 dbSNP
rs1442586346 2239 dbSNP
rs1214490652 2241 dbSNP
rs938618142 2244 dbSNP
rs1488979534 2252 dbSNP
rs1031468877 2253 dbSNP
rs1000023557 2262 dbSNP
rs1477273937 2273 dbSNP
rs1174630078 2279 dbSNP
rs554616867 2279 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000438150.2 | 3UTR | CACAGAUGUAAGGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.779 0.11 0.800 0.1 4 Click to see details
BRCA -0.649 0.12 -0.700 0.09 5 Click to see details
LUSC -0.59 0.21 -0.400 0.3 4 Click to see details
HNSC -0.275 0.28 -0.214 0.32 7 Click to see details
HNSC -0.275 0.28 -0.214 0.32 7 Click to see details
HNSC -0.275 0.28 -0.214 0.32 7 Click to see details
HNSC -0.275 0.28 -0.214 0.32 7 Click to see details
HNSC -0.275 0.28 -0.214 0.32 7 Click to see details
HNSC -0.275 0.28 -0.214 0.32 7 Click to see details
HNSC -0.275 0.28 -0.214 0.32 7 Click to see details
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT207399 MAT2A methionine adenosyltransferase 2A 2 6
MIRT284537 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT291946 TPM4 tropomyosin 4 2 2
MIRT293609 PVR poliovirus receptor 2 2
MIRT357688 PAIP2 poly(A) binding protein interacting protein 2 2 2
MIRT451607 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452110 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT457804 KLHL25 kelch like family member 25 2 2
MIRT462730 EFNB1 ephrin B1 2 2
MIRT463219 ZNF131 zinc finger protein 131 2 2
MIRT464141 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT467582 SLC7A5 solute carrier family 7 member 5 2 6
MIRT470824 PLXND1 plexin D1 2 2
MIRT474230 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT478989 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479462 CDK6 cyclin dependent kinase 6 2 2
MIRT483558 SYT2 synaptotagmin 2 2 2
MIRT484483 SLC9A1 solute carrier family 9 member A1 2 2
MIRT485224 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490356 DPYSL5 dihydropyrimidinase like 5 2 4
MIRT493177 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT509802 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511815 HDGF heparin binding growth factor 2 2
MIRT512254 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT513025 GPT2 glutamic--pyruvic transaminase 2 2 2
MIRT519640 ZNF772 zinc finger protein 772 2 4
MIRT531178 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT537870 EDA2R ectodysplasin A2 receptor 2 2
MIRT551914 IGLON5 IgLON family member 5 2 2
MIRT558359 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT559771 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT559813 ZNF83 zinc finger protein 83 2 2
MIRT561999 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT565754 SERTAD2 SERTA domain containing 2 2 2
MIRT569423 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569845 RGS5 regulator of G protein signaling 5 2 2
MIRT606928 CDK15 cyclin dependent kinase 15 2 2
MIRT607616 TMEM130 transmembrane protein 130 2 4
MIRT607629 TRIOBP TRIO and F-actin binding protein 2 2
MIRT607885 SATB1 SATB homeobox 1 2 2
MIRT607942 SSX2 SSX family member 2 2 4
MIRT608017 CARNS1 carnosine synthase 1 2 4
MIRT608036 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608063 SSX2B SSX family member 2B 2 4
MIRT608558 SBK1 SH3 domain binding kinase 1 2 6
MIRT608915 NCDN neurochondrin 2 6
MIRT615876 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT618023 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT620505 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT628101 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 2
MIRT628700 ZNF548 zinc finger protein 548 2 2
MIRT630658 POU2F1 POU class 2 homeobox 1 2 2
MIRT643508 ZNF28 zinc finger protein 28 2 2
MIRT646379 SLC22A6 solute carrier family 22 member 6 2 2
MIRT660041 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT687700 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT688858 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT690443 REPIN1 replication initiator 1 2 2
MIRT690456 ZNF33A zinc finger protein 33A 2 2
MIRT693796 RHOG ras homolog family member G 2 2
MIRT694274 ZNF529 zinc finger protein 529 2 4
MIRT697697 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700242 RCC2 regulator of chromosome condensation 2 2 2
MIRT701836 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT704255 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT707203 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT710365 CREB5 cAMP responsive element binding protein 5 2 2
MIRT711943 WDFY1 WD repeat and FYVE domain containing 1 2 2
MIRT715496 MAZ MYC associated zinc finger protein 2 2
MIRT719250 MS4A1 membrane spanning 4-domains A1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3911 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3911 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3911 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3911 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-mir-3911 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-3911 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-3911 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3911 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3911 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3911 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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