pre-miRNA Information
pre-miRNA hsa-mir-4301   
Genomic Coordinates chr11: 113450023 - 113450088
Description Homo sapiens miR-4301 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4301
Sequence 11| UCCCACUACUUCACUUGUGA |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs184176277 2 dbSNP
rs1191324913 13 dbSNP
rs1369198005 15 dbSNP
rs1036973189 16 dbSNP
rs944900541 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KANSL3   
Synonyms KIAA1310, NSL3, Rcd1
Description KAT8 regulatory NSL complex subunit 3
Transcript NM_001115016   
Expression
Putative miRNA Targets on KANSL3
3'UTR of KANSL3
(miRNA target sites are highlighted)
>KANSL3|NM_001115016|3'UTR
   1 AGATGCTGTGTGATATGTCCTCCTTACCAAGTTGGTGATGGCTGCCTCATGGTGGGCCCTGGACAGGTGTGTGGTCCTGC
  81 TGAGCTGTCCACGTGTCGGAAGACCTGTTTAAGACAGTCATTTTTGCCTCTCCGCCAACTGTCTTCAGAGAAACCATTAG
 161 GTTAGGTGATACGGTGCCAGCAAGGGAAGCACCATCGTCCAGGATCTGCAAATCTGGTTCCTGGGAACCCCAGACTCCTC
 241 AGCAGATCTGGCTGTACATGGATCAGAACCACTTCTTCCCCCGCTTAAGCTGTGGTTTGACCCAAGGGTCAGCATATAGG
 321 ACTGCCTGCTGCATTTAATGAAGGTGTTTCCTTTTGGAAGTCTGTGCTACCCTCTGCGCCTAGTTGGGAGGAGACATCCA
 401 TCTGGTCTGGGATTTCGGGAGTTAGAATGGAAAGCTCTTTGCTAAAGACTGGAGTCATCCTGGCCTGCCAACTGGTGGTT
 481 CAGAGCCGGACGGGCTTGTTTTGGACATCACTGTTGCCTTCACTCAGCAGCCACGGGAGAGTGCTCCCCATGCAACTCCA
 561 CCTTAGAAACCACGTCAGATACTGAGTAGCTTGCTGACTCCTGGAAACTTCTGGTTTTTGTTAGTATCATAATGAAGGCA
 641 AAGAGAACTAGGCTGTCATCTTTCAGCCTCTTTGACTTACTCTAGATGTTGGGAGCAGTGGTTGCCAGGTGAAACCTGGG
 721 CCCTTTGTCTTTTTCACCATGCTTTGGGCAGTTTCTGTATCCAGAGAGTCCGCAGGTTCAGATAAGCTGAAGAAGAGTAA
 801 TAGAACAGCAAAGGAAGTGGCTTGAAGGATGTGCTAGTAAGCCCTGTGGTTTGTGCTTAGGTCTCTGCTCTGCTACCCAA
 881 GGAACTGGTGGTTCAGCTGGAGATAAAAAGAAGAATTTGCCAAGTCAGAGAAGAAACCCCAACCCCGGAAAATCCTCTGT
 961 CTCCAGTCTCTGGAGGTGAAGCAGGGACAATAAGCTAAGGTAGTATCTTGGCCATCCCAGGAAACTTGTGGCATTAGGAC
1041 GATGAAGGCCATGCTTCAGTGTTTTCGTTTCTATTTCATGAGACTTTTTGTCTTCCTGCTTACAAGTGGGAAGATGATTG
1121 ACAGTGACTCTACTATGCAGGGCTGTTGGTACCAACCTGAGCCCTATAGGTGGCAGTCCCTGGAGAAGTGGTCACAGAAG
1201 ATGGAGCTCTGATCCCCTGCTTACCTCTTCACAACACTTGTGTGCAAAGATAGTTTTAGATTTGGTTTAGAAGCTATCCT
1281 CCAGAACAGGCTCCCATACTTAGAATGTTTCTAGTTAAGGTAATAAATTAGGCAACCCAAGTGTGACTCCACTCAAGTGT
1361 CCTTTTCTGTAGGCAGGAAGGGCCCACAACATGGCTTAAAATGTAGTCCATGGTTCTGGCCCACAGTACAGTGTGTATCT
1441 ATACCAGGTCACCTGTGTTCAATCTGGGAGCCTTCCTGGCCAGTCTGAGTGGCAGCCAGAAGGGAGCTCATAGTGTCTAG
1521 GAGTCTCAGGCAAGGTAGGTCAGGGTACTGTGGGCAGGGGGGATGTGTGTGATAGGAGAGGGTACCCTAAACCCCATACC
1601 TTCCCTCCCTGACCTGAAAAGCTGATCTCAACAGGGATTCACACAGAATTAGGCTGTGTTTTTGCATTAGCTGGTAGGTG
1681 ACTTTCTCAAAATTCTTAAATTCAGAAAGTATTTAGTAAACTTGAGGAAGGTATGAAATCTGGAGGAGGCATCCAGGACC
1761 CAGGGGTTTGATAGCTTTACAGGTAGGATCATACCACACCAAAAGAGCAGTGGACAATAAGACTATATGAGCTATATGAA
1841 GCTTTTAGGAATCATTTAGGACAGACAGAGCCCTAAACAACCCATTCATGACTTAAGTTGTTGGCTCAGTGTATGCTGGG
1921 GACAAAGAAAAACTAACAAGCCGACCTGCCTTTATGATAAATTCTAGTGTGCTTACAAGGGATGACTTCCTGAGGTGTGA
2001 TCTGTCCACCTTGAAGAACTCCACAACTGAAGAAGGGGAGCTGTGAGAACGTGGATTGTTCTACAACTTGCACAGGGTAA
2081 CAGAGGAAGTGGCTGAGGCCTAGAGTCACGTTTTCCAGTTCCCTTCGCAAACTATATTTCTTGGAACGCGAAAGGAAGCT
2161 TTACCTATTTCATAGAAGACCTGGAATCCATAACCTCAGAAGGCAATATTATTGATAGAAAATGTGGAAGGATCAGGAAG
2241 TTCTTAGATTCTTGGATGACAGATGCATGTTGATGCCCTATGGAGATGTCCTTGTGTTTTGAGGTCACTGAGGTAGGAAG
2321 ACCTGTCTACTCTTGGTTTCACCACTAGAACAGTCTTGGGCTGGATGGGTTATAGAGCTGAGCGGCTGTGATGGTTCTGT
2401 TTTTACATTAACAAAAACAATTAAAAACACCAAAAACAACATTTGGATTGCTTCAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aguGUUCACUUCAUCACCcu 5'
             |||| ||| |:||||  
Target 5' accCAAG-GAACTGGTGGtt 3'
875 - 893 128.00 -12.40
2
miRNA  3' aguguucacuucAUCACCCu 5'
                      |:||||| 
Target 5' atggctgcctcaTGGTGGGc 3'
38 - 57 124.00 -9.30
3
miRNA  3' aguguucacuucaUCACCCu 5'
                       |||||| 
Target 5' cttcctgcttacaAGTGGGa 3'
1092 - 1111 120.00 -10.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26980927 6 COSMIC
COSN26141235 10 COSMIC
COSN30452043 23 COSMIC
COSN30154055 29 COSMIC
COSN30504364 56 COSMIC
COSN30492599 59 COSMIC
COSN30119932 66 COSMIC
COSN21061082 80 COSMIC
COSN31588985 92 COSMIC
COSN30112092 150 COSMIC
COSN31559336 150 COSMIC
COSN20239470 174 COSMIC
COSN25870551 344 COSMIC
COSN25791063 550 COSMIC
COSN1862952 686 COSMIC
COSN5963191 708 COSMIC
COSN32062913 1504 COSMIC
COSN1862951 2051 COSMIC
COSN32057608 2127 COSMIC
COSN30712072 2383 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1175423693 2 dbSNP
rs771952350 3 dbSNP
rs748149284 6 dbSNP
rs1027005292 7 dbSNP
rs778649273 9 dbSNP
rs754817425 16 dbSNP
rs1411971579 22 dbSNP
rs1322095475 24 dbSNP
rs780738120 25 dbSNP
rs754652891 27 dbSNP
rs753619611 28 dbSNP
rs1478966400 34 dbSNP
rs780323665 40 dbSNP
rs1193110904 42 dbSNP
rs756300952 46 dbSNP
rs537412404 51 dbSNP
rs899084582 52 dbSNP
rs752047870 60 dbSNP
rs568859141 67 dbSNP
rs565403468 69 dbSNP
rs1379900654 77 dbSNP
rs766745374 80 dbSNP
rs552282945 91 dbSNP
rs1277154732 95 dbSNP
rs1039000305 97 dbSNP
rs1301486826 98 dbSNP
rs1344666717 104 dbSNP
rs906392261 133 dbSNP
rs1436395779 134 dbSNP
rs1273379092 138 dbSNP
rs1437019465 141 dbSNP
rs1202305696 143 dbSNP
rs1347327436 147 dbSNP
rs1046639077 148 dbSNP
rs1248406376 149 dbSNP
rs1316591479 153 dbSNP
rs1454316265 166 dbSNP
rs945162638 170 dbSNP
rs185208368 171 dbSNP
rs1053462432 172 dbSNP
rs1391804164 172 dbSNP
rs936304811 186 dbSNP
rs1054693753 194 dbSNP
rs144858791 196 dbSNP
rs1326084806 197 dbSNP
rs1422868520 200 dbSNP
rs1384646922 207 dbSNP
rs867449296 212 dbSNP
rs1395905106 216 dbSNP
rs975672494 217 dbSNP
rs548058553 222 dbSNP
rs924763049 225 dbSNP
rs1324039255 231 dbSNP
rs1367461417 235 dbSNP
rs1045931389 238 dbSNP
rs1269860030 240 dbSNP
rs746091012 241 dbSNP
rs1212633941 254 dbSNP
rs1274937912 272 dbSNP
rs527889678 278 dbSNP
rs1475668486 282 dbSNP
rs944282555 283 dbSNP
rs1193395426 284 dbSNP
rs1372196291 289 dbSNP
rs750803124 292 dbSNP
rs912755506 295 dbSNP
rs1419199106 307 dbSNP
rs1461329793 313 dbSNP
rs1163411215 319 dbSNP
rs1390873004 338 dbSNP
rs193043022 341 dbSNP
rs1224201320 343 dbSNP
rs962620950 344 dbSNP
rs149395369 346 dbSNP
rs531585448 358 dbSNP
rs951509484 362 dbSNP
rs1324943156 372 dbSNP
rs909827136 377 dbSNP
rs1027451297 378 dbSNP
rs974151539 379 dbSNP
rs1335249468 384 dbSNP
rs958728472 400 dbSNP
rs1034336558 405 dbSNP
rs371592331 407 dbSNP
rs190481779 416 dbSNP
rs576969845 417 dbSNP
rs1444986974 419 dbSNP
rs775135228 421 dbSNP
rs553849514 424 dbSNP
rs1163340257 427 dbSNP
rs892219833 436 dbSNP
rs1454343423 440 dbSNP
rs1158136442 446 dbSNP
rs998016842 447 dbSNP
rs966125811 460 dbSNP
rs140946538 463 dbSNP
rs1007587503 471 dbSNP
rs1291329212 474 dbSNP
rs893127591 487 dbSNP
rs368168456 488 dbSNP
rs554543037 491 dbSNP
rs899538631 492 dbSNP
rs1212530337 493 dbSNP
rs1421637182 495 dbSNP
rs748335832 498 dbSNP
rs1186300194 502 dbSNP
rs1253277694 505 dbSNP
rs903356710 512 dbSNP
rs944312711 513 dbSNP
rs1269271050 516 dbSNP
rs185033927 522 dbSNP
rs575117726 526 dbSNP
rs1045867356 530 dbSNP
rs1201147774 534 dbSNP
rs192476361 548 dbSNP
rs549276022 550 dbSNP
rs774443422 551 dbSNP
rs11541470 559 dbSNP
rs930175532 564 dbSNP
rs1310908218 567 dbSNP
rs1055934144 568 dbSNP
rs1391834393 569 dbSNP
rs566526419 570 dbSNP
rs546727953 571 dbSNP
rs1271556022 573 dbSNP
rs534104798 574 dbSNP
rs1303646288 578 dbSNP
rs1346781108 584 dbSNP
rs974182404 585 dbSNP
rs568665808 593 dbSNP
rs909544227 594 dbSNP
rs1253387138 600 dbSNP
rs1481166246 608 dbSNP
rs1324746004 612 dbSNP
rs1195688796 613 dbSNP
rs982702092 629 dbSNP
rs1455620314 633 dbSNP
rs958759128 634 dbSNP
rs1285523062 638 dbSNP
rs1403343119 643 dbSNP
rs1452753492 644 dbSNP
rs927295774 652 dbSNP
rs981410622 654 dbSNP
rs929861168 656 dbSNP
rs970676329 663 dbSNP
rs1345187582 666 dbSNP
rs1025269960 667 dbSNP
rs1444506620 680 dbSNP
rs1394294353 695 dbSNP
rs1009486148 701 dbSNP
rs1326060296 707 dbSNP
rs1369629211 716 dbSNP
rs1003793682 725 dbSNP
rs1308397498 726 dbSNP
rs1017715605 727 dbSNP
rs1032124199 735 dbSNP
rs1470264827 737 dbSNP
rs1214879001 759 dbSNP
rs1252383233 762 dbSNP
rs957394765 765 dbSNP
rs553474601 766 dbSNP
rs147259984 771 dbSNP
rs774103948 772 dbSNP
rs1479324318 779 dbSNP
rs376134280 782 dbSNP
rs1462896108 797 dbSNP
rs1165567443 802 dbSNP
rs1393044239 813 dbSNP
rs1438105439 818 dbSNP
rs1290238254 830 dbSNP
rs891380424 830 dbSNP
rs1381996524 834 dbSNP
rs748972231 836 dbSNP
rs1337415911 837 dbSNP
rs1481348609 841 dbSNP
rs186955702 842 dbSNP
rs1204460981 846 dbSNP
rs1332744423 853 dbSNP
rs1218084190 855 dbSNP
rs1242908667 868 dbSNP
rs1485695911 876 dbSNP
rs1185009374 878 dbSNP
rs34124545 879 dbSNP
rs930230104 880 dbSNP
rs1476083101 887 dbSNP
rs1188504035 889 dbSNP
rs1265540240 890 dbSNP
rs920113803 892 dbSNP
rs1222129330 899 dbSNP
rs1403093328 916 dbSNP
rs1014448658 925 dbSNP
rs1038521860 928 dbSNP
rs28362544 940 dbSNP
rs1295999734 943 dbSNP
rs143920144 946 dbSNP
rs981441719 951 dbSNP
rs1371289836 960 dbSNP
rs1354182863 961 dbSNP
rs1225525170 962 dbSNP
rs1284972300 968 dbSNP
rs778027770 977 dbSNP
rs1046684241 981 dbSNP
rs182096414 987 dbSNP
rs1486516311 991 dbSNP
rs1406806409 1000 dbSNP
rs1338596280 1002 dbSNP
rs1211416336 1003 dbSNP
rs879279283 1013 dbSNP
rs748440134 1016 dbSNP
rs192727374 1020 dbSNP
rs1178884726 1031 dbSNP
rs1408027553 1039 dbSNP
rs977060029 1040 dbSNP
rs956632328 1041 dbSNP
rs942581456 1050 dbSNP
rs1312711932 1051 dbSNP
rs574527012 1066 dbSNP
rs561172660 1067 dbSNP
rs1420447008 1072 dbSNP
rs1222183960 1078 dbSNP
rs11541469 1081 dbSNP
rs1305860335 1091 dbSNP
rs1348944794 1097 dbSNP
rs544171462 1105 dbSNP
rs368548615 1109 dbSNP
rs1279258256 1114 dbSNP
rs1176193907 1118 dbSNP
rs963772653 1132 dbSNP
rs1206483538 1136 dbSNP
rs1444703402 1139 dbSNP
rs550441666 1140 dbSNP
rs538598241 1149 dbSNP
rs758955845 1155 dbSNP
rs1245564299 1163 dbSNP
rs1007968885 1164 dbSNP
rs977398023 1166 dbSNP
rs1454400230 1167 dbSNP
rs1172626854 1171 dbSNP
rs890815784 1196 dbSNP
rs967766066 1201 dbSNP
rs1412019657 1212 dbSNP
rs1461163977 1216 dbSNP
rs1354508214 1219 dbSNP
rs1444640419 1221 dbSNP
rs1327943524 1235 dbSNP
rs1261620842 1237 dbSNP
rs1025290053 1259 dbSNP
rs572893045 1265 dbSNP
rs1216153943 1266 dbSNP
rs1014913665 1268 dbSNP
rs1306902587 1270 dbSNP
rs958942506 1271 dbSNP
rs7585764 1277 dbSNP
rs1038553908 1278 dbSNP
rs1005271761 1281 dbSNP
rs1385038458 1287 dbSNP
rs937450246 1291 dbSNP
rs1317120919 1319 dbSNP
rs1244669603 1320 dbSNP
rs888172870 1326 dbSNP
rs188115433 1337 dbSNP
rs17119523 1342 dbSNP
rs1289168116 1346 dbSNP
rs1455149210 1347 dbSNP
rs1046271346 1351 dbSNP
rs1343132674 1356 dbSNP
rs1167779257 1357 dbSNP
rs1395249627 1361 dbSNP
rs950152213 1363 dbSNP
rs913249076 1369 dbSNP
rs988806931 1382 dbSNP
rs1328492872 1394 dbSNP
rs1432625921 1397 dbSNP
rs780542044 1410 dbSNP
rs925169115 1428 dbSNP
rs1216678193 1429 dbSNP
rs1274997121 1431 dbSNP
rs779486867 1431 dbSNP
rs963885977 1434 dbSNP
rs1041003596 1435 dbSNP
rs1386506777 1448 dbSNP
rs1448314694 1452 dbSNP
rs942570377 1454 dbSNP
rs1444489701 1458 dbSNP
rs1241854987 1481 dbSNP
rs1477059991 1484 dbSNP
rs1190671899 1487 dbSNP
rs138429817 1496 dbSNP
rs1460985901 1501 dbSNP
rs1188716192 1504 dbSNP
rs1485082594 1507 dbSNP
rs1387246490 1510 dbSNP
rs986978738 1512 dbSNP
rs955126325 1519 dbSNP
rs911068375 1520 dbSNP
rs1025743943 1521 dbSNP
rs1339541829 1522 dbSNP
rs147766052 1528 dbSNP
rs377602488 1528 dbSNP
rs559535765 1528 dbSNP
rs1295016983 1541 dbSNP
rs993813215 1545 dbSNP
rs936090272 1550 dbSNP
rs374499221 1554 dbSNP
rs1243415078 1557 dbSNP
rs1281855144 1562 dbSNP
rs1352256962 1569 dbSNP
rs1205306129 1571 dbSNP
rs538056553 1577 dbSNP
rs926052097 1583 dbSNP
rs1361715098 1594 dbSNP
rs898749669 1596 dbSNP
rs1289615186 1600 dbSNP
rs1017234591 1601 dbSNP
rs1213552104 1605 dbSNP
rs541086176 1614 dbSNP
rs1321120630 1616 dbSNP
rs906061129 1627 dbSNP
rs34686678 1637 dbSNP
rs1365564741 1639 dbSNP
rs1045884272 1641 dbSNP
rs571167991 1646 dbSNP
rs1158187073 1651 dbSNP
rs1358908339 1657 dbSNP
rs1417625749 1659 dbSNP
rs752442075 1669 dbSNP
rs967439952 1677 dbSNP
rs1053538656 1685 dbSNP
rs767296724 1699 dbSNP
rs552464567 1704 dbSNP
rs1395343173 1705 dbSNP
rs1297224450 1708 dbSNP
rs1332143822 1709 dbSNP
rs1336993654 1718 dbSNP
rs532341298 1721 dbSNP
rs1405117605 1731 dbSNP
rs1308073235 1733 dbSNP
rs1351133639 1740 dbSNP
rs1236063960 1753 dbSNP
rs935964965 1756 dbSNP
rs1281403550 1759 dbSNP
rs1366896073 1761 dbSNP
rs541493080 1764 dbSNP
rs1253339610 1772 dbSNP
rs917236544 1776 dbSNP
rs1456954717 1781 dbSNP
rs1378684039 1785 dbSNP
rs1374195614 1791 dbSNP
rs560146236 1794 dbSNP
rs942602434 1798 dbSNP
rs959183892 1800 dbSNP
rs1465403918 1801 dbSNP
rs577514265 1806 dbSNP
rs1300980920 1810 dbSNP
rs1398633643 1813 dbSNP
rs1427137347 1816 dbSNP
rs1391452791 1817 dbSNP
rs911064125 1825 dbSNP
rs1442593995 1836 dbSNP
rs1200438765 1837 dbSNP
rs986621653 1843 dbSNP
rs1303716815 1856 dbSNP
rs1311950530 1865 dbSNP
rs1005697254 1870 dbSNP
rs1253590316 1872 dbSNP
rs1340754082 1883 dbSNP
rs1198585624 1888 dbSNP
rs1236390830 1891 dbSNP
rs952868438 1911 dbSNP
rs1194482533 1918 dbSNP
rs1266991055 1925 dbSNP
rs1025379567 1928 dbSNP
rs1173767801 1936 dbSNP
rs746293464 1942 dbSNP
rs1340131748 1943 dbSNP
rs1462377198 1944 dbSNP
rs546765415 1945 dbSNP
rs1251858428 1956 dbSNP
rs900836895 1957 dbSNP
rs751081877 1961 dbSNP
rs1366546383 1968 dbSNP
rs1041073261 1972 dbSNP
rs1298109315 1974 dbSNP
rs1218510372 1976 dbSNP
rs1327394158 1976 dbSNP
rs1256770106 1977 dbSNP
rs1337004365 1979 dbSNP
rs1214472175 1981 dbSNP
rs1305564386 1982 dbSNP
rs11690659 1986 dbSNP
rs889686302 1997 dbSNP
rs1223890203 2001 dbSNP
rs1016599616 2009 dbSNP
rs1001812190 2010 dbSNP
rs1053686662 2011 dbSNP
rs936520014 2013 dbSNP
rs970276315 2018 dbSNP
rs923762542 2019 dbSNP
rs141428416 2024 dbSNP
rs1164931077 2025 dbSNP
rs1385767940 2026 dbSNP
rs148268166 2030 dbSNP
rs891878980 2031 dbSNP
rs1290297454 2043 dbSNP
rs1053248475 2045 dbSNP
rs530734479 2050 dbSNP
rs917265241 2051 dbSNP
rs1423363974 2052 dbSNP
rs1177690621 2065 dbSNP
rs1357980330 2069 dbSNP
rs1234457628 2071 dbSNP
rs1481616797 2071 dbSNP
rs993212559 2073 dbSNP
rs1427523296 2079 dbSNP
rs1198387585 2084 dbSNP
rs143193386 2085 dbSNP
rs1252685681 2088 dbSNP
rs545349918 2109 dbSNP
rs762000707 2110 dbSNP
rs1479654528 2115 dbSNP
rs1257329609 2117 dbSNP
rs115748440 2127 dbSNP
rs984329205 2133 dbSNP
rs952919350 2140 dbSNP
rs552973247 2147 dbSNP
rs1160803948 2148 dbSNP
rs768899748 2149 dbSNP
rs911106097 2150 dbSNP
rs1281007488 2156 dbSNP
rs1051371477 2158 dbSNP
rs933876568 2159 dbSNP
rs542353790 2160 dbSNP
rs1377659495 2167 dbSNP
rs972515333 2169 dbSNP
rs1232010905 2172 dbSNP
rs1302803170 2184 dbSNP
rs1377031305 2209 dbSNP
rs918405582 2210 dbSNP
rs1307968755 2213 dbSNP
rs149078235 2214 dbSNP
rs1238262516 2224 dbSNP
rs1283532139 2225 dbSNP
rs965475018 2227 dbSNP
rs1019298612 2228 dbSNP
rs1236877107 2239 dbSNP
rs370108849 2243 dbSNP
rs972508266 2255 dbSNP
rs747001731 2256 dbSNP
rs1178491868 2258 dbSNP
rs1006993166 2260 dbSNP
rs889443527 2261 dbSNP
rs1389175988 2262 dbSNP
rs1032295578 2276 dbSNP
rs750554033 2277 dbSNP
rs909567956 2280 dbSNP
rs1397222541 2296 dbSNP
rs1446840461 2299 dbSNP
rs183519893 2312 dbSNP
rs979738605 2313 dbSNP
rs1312690893 2315 dbSNP
rs1346348926 2315 dbSNP
rs1000782296 2320 dbSNP
rs1280186872 2322 dbSNP
rs1332054286 2327 dbSNP
rs754598298 2330 dbSNP
rs1444784503 2333 dbSNP
rs1368112422 2341 dbSNP
rs777441102 2344 dbSNP
rs1430995710 2352 dbSNP
rs1325709525 2357 dbSNP
rs1315976831 2359 dbSNP
rs1415911343 2361 dbSNP
rs1376025193 2365 dbSNP
rs1172899596 2366 dbSNP
rs1042581004 2367 dbSNP
rs780237202 2369 dbSNP
rs191991341 2371 dbSNP
rs1392084284 2375 dbSNP
rs1168775678 2376 dbSNP
rs1475208790 2383 dbSNP
rs752107807 2384 dbSNP
rs1190080286 2387 dbSNP
rs1486182012 2392 dbSNP
rs1238213608 2393 dbSNP
rs1014919936 2398 dbSNP
rs1057203954 2400 dbSNP
rs1254534421 2428 dbSNP
rs1478556419 2434 dbSNP
rs1365754766 2440 dbSNP
rs569126884 2440 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' aguguucacuucaUCACCCu 5'
                       |||||| 
Target 5' ------------aAGUGGGa 3'
1 - 8
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000431828.1 | 3UTR | AAGUGGGAAGAUGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4301 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081134 LDLR low density lipoprotein receptor 2 4
MIRT090911 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT229436 MECP2 methyl-CpG binding protein 2 2 2
MIRT274717 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT350957 BACH1 BTB domain and CNC homolog 1 2 2
MIRT386722 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT446022 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT481303 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 14
MIRT483959 ZNF354B zinc finger protein 354B 2 6
MIRT495667 TUBAL3 tubulin alpha like 3 2 2
MIRT496554 TBX15 T-box 15 2 2
MIRT497702 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT498105 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT512535 SEMA4D semaphorin 4D 2 2
MIRT512556 MFN2 mitofusin 2 2 6
MIRT521465 RABGAP1 RAB GTPase activating protein 1 2 6
MIRT526236 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526743 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527578 BRD7 bromodomain containing 7 2 4
MIRT528038 WT1 Wilms tumor 1 2 2
MIRT528267 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT528505 HTR7 5-hydroxytryptamine receptor 7 2 4
MIRT528758 RPS27 ribosomal protein S27 2 6
MIRT528999 IPO9 importin 9 2 2
MIRT529701 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529781 C17orf82 chromosome 17 open reading frame 82 2 2
MIRT533797 TMEM119 transmembrane protein 119 2 6
MIRT535308 PHF12 PHD finger protein 12 2 2
MIRT535917 MKL2 MKL1/myocardin like 2 2 2
MIRT544892 OSBPL1A oxysterol binding protein like 1A 2 2
MIRT555423 PPIC peptidylprolyl isomerase C 2 2
MIRT562068 KLHL15 kelch like family member 15 2 2
MIRT565623 SLC31A1 solute carrier family 31 member 1 2 2
MIRT565661 SIX1 SIX homeobox 1 2 2
MIRT570138 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT571045 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT621232 LMAN1 lectin, mannose binding 1 2 2
MIRT622272 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623844 GAN gigaxonin 2 2
MIRT626158 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626464 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT632087 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT637243 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT642710 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT643611 KANSL3 KAT8 regulatory NSL complex subunit 3 2 2
MIRT644270 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 2 2
MIRT645470 SPIN3 spindlin family member 3 2 2
MIRT649193 DNPEP aspartyl aminopeptidase 2 2
MIRT650776 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT651345 ZC2HC1C zinc finger C2HC-type containing 1C 2 2
MIRT652237 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT652587 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654591 PURA purine rich element binding protein A 2 2
MIRT654649 PTAFR platelet activating factor receptor 2 2
MIRT656842 KLF7 Kruppel like factor 7 2 2
MIRT657209 IKZF2 IKAROS family zinc finger 2 2 2
MIRT658513 ETV3 ETS variant 3 2 2
MIRT659448 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT668816 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT669067 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT677711 ELOF1 elongation factor 1 homolog 2 4
MIRT687146 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT698498 THOC2 THO complex 2 2 2
MIRT707930 PPP1R3D protein phosphatase 1 regulatory subunit 3D 4 2
MIRT708737 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT710031 POLL DNA polymerase lambda 2 2
MIRT712175 STK4 serine/threonine kinase 4 2 2
MIRT715297 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT716892 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT717378 RBM41 RNA binding motif protein 41 2 2
MIRT718082 CLIC5 chloride intracellular channel 5 2 2
MIRT718721 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT719152 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719224 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719528 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT719861 KLF2 Kruppel like factor 2 2 2
MIRT720326 CAMK2G calcium/calmodulin dependent protein kinase II gamma 2 2
MIRT721596 SREBF1 sterol regulatory element binding transcription factor 1 2 2
MIRT722020 NEBL nebulette 2 2
MIRT722484 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT722614 TEAD1 TEA domain transcription factor 1 2 2
MIRT723664 RPTN repetin 2 2
MIRT723939 SVOP SV2 related protein 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive High Hepatocellular Carcinoma cell line (Hep3B, 97L)
hsa-miR-4301 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-4301 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-4301 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-4301 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-miR-4301 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission