pre-miRNA Information
pre-miRNA hsa-mir-1303   
Genomic Coordinates chr5: 154685776 - 154685861
Synonyms MIRN1303, hsa-mir-1303, MIR1303
Description Homo sapiens miR-1303 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1303
Sequence 52| UUUAGAGACGGGGUCUUGCUCU |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 5 + 154685830 23291724, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370437195 6 dbSNP
rs1195001383 7 dbSNP
rs546614687 8 dbSNP
rs762579883 9 dbSNP
rs766041486 10 dbSNP
rs751079975 12 dbSNP
rs888516744 13 dbSNP
rs566454487 14 dbSNP
rs766973220 15 dbSNP
rs1474274822 17 dbSNP
rs753222192 18 dbSNP
rs1230907999 19 dbSNP
rs756552638 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol IPP   
Synonyms KLHL27
Description intracisternal A particle-promoted polypeptide
Transcript NM_005897   
Other Transcripts NM_001145349   
Expression
Putative miRNA Targets on IPP
3'UTR of IPP
(miRNA target sites are highlighted)
>IPP|NM_005897|3'UTR
   1 AATATAAAGCATAACAGAGCACAAGGAACATTTTGAAAATGCAGGACCTGACCTTTTGCAAAGCAAACATAGATTTGGTG
  81 ATAAGACCCTCTGATTCTGTGAGTTTTCCATGTATTTGGTAGATAAATGACTAACGAGGCTGGGCGCAGTGGCCTCATGC
 161 CTATAATCCCAGCACTTTGGAAGGCTGAGGCAGAAGGATCACTTGAGCCCAGGAATTTGAGGTTGTAGTAAGCTACGATC
 241 ATGCCACTGCACTCCACTCTGGGCAACAGAATGAGATCCTGTCTCTTAAAGAAAAAAAATAAACTCAAGAATGATTTTTC
 321 TAAAAATATGAGTGAGAATGGATATGGAATATATCCCAATTAATAAAGAGCTCACACAGATTTGCCAGGTTTACTAATAA
 401 TAGAAATGCCATTTATGCTGTAGAATTCTCCAGTTTAAGTGTAGACAACTCCTATTTTACAAATTTGTAGAAATTATTTA
 481 CTAGAAGCTTCCTGGCAAATAGTCCCTTTAGCTACTTCTCCAGTGCAGTATAAATTGTAACATAAAACTTTATGTGATAT
 561 AGGAATAGTGTCAATGACACAGTTTAAAGACCTCTATATTCACAATTATATCCAGAGCATAATTTTCCATGGCCATAGTT
 641 TGAGCCACAGAGAAAGCCAATGAAATAGATTCCTACTTTTATTTAATGCCAAGAGTTTTCACTAGCCCCAAACTTTTTAT
 721 TGGCAGCAGATATCCTAGGAGGGGTGTTTGGGAAATATCTAGCTATTTTAATAGATAGATACCTTTTTGCTTGATGATAA
 801 GTTTTTGCTTGCTCATATTTTTTGTCTTGATCCTGAGAATGCAAGTAAGGAATTAATAGGAGGTTCTTAGTGACCAGATG
 881 TTGTAATGGGCTATACAGTCCAGCAGGCAGTATGCACCTAGAAATTTCTCCCTTTTTTAGGCTGGGCATGGTGGCTCACA
 961 CCTGTAATCCCAGCACTTTGAGAGGCCGAGGTGAGACGGGAAGATGGCTTGAACTCAGGAGTTCGAGACTAGCCTGGGCA
1041 ACGTGATGAGACTCCGTCTCTACCAAAAAATATATAAAAATTAGCCGGGCGTTGTGGCTTGTACCTGTGGTCCCATCTGC
1121 TTGGGAGGCTGAGGTTGCAGGATCACTTGAGCCCAGGAGGTCAAGGCTGCAGTGAGCCAAGATTGTGCCACTGCACACCG
1201 GCCTGGGTGACAGCATGAGAACCTGTCTCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucucGUUCUGGGGCAGAGAUuu 5'
              ::||||:|||||||||  
Target 5' gtgaTGAGACTCCGTCTCTAcc 3'
1043 - 1064 158.00 -23.50
2
miRNA  3' ucUCGU--UCUGGGGCAGAGAUUu 5'
            ||||  ||| ||:||||| || 
Target 5' acAGCATGAGAACCTGTCTCAAAa 3'
1210 - 1233 146.00 -18.70
3
miRNA  3' ucUCGUUCUGGGGCAGAGAUUu 5'
            | ::|||:||:|||||| | 
Target 5' agAATGAGATCCTGTCTCTTAa 3'
268 - 289 144.00 -25.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30455801 9 COSMIC
COSN30171596 15 COSMIC
COSN30527817 17 COSMIC
COSN16130351 42 COSMIC
COSN30662109 46 COSMIC
COSN18725321 99 COSMIC
COSN16629244 145 COSMIC
COSN30175325 164 COSMIC
COSN22346070 379 COSMIC
COSN27520460 408 COSMIC
COSN21354540 647 COSMIC
COSN23883691 1090 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1447189093 5 dbSNP
rs1171139171 16 dbSNP
rs1478003588 17 dbSNP
rs375523749 20 dbSNP
rs1201613409 22 dbSNP
rs896030608 25 dbSNP
rs372270104 26 dbSNP
rs1251537132 39 dbSNP
rs938986016 42 dbSNP
rs1203709582 43 dbSNP
rs902277917 51 dbSNP
rs562105215 66 dbSNP
rs1336419553 72 dbSNP
rs777140233 90 dbSNP
rs1393888921 93 dbSNP
rs116792274 99 dbSNP
rs915066738 101 dbSNP
rs189513618 110 dbSNP
rs1471347779 114 dbSNP
rs981819242 119 dbSNP
rs943298894 121 dbSNP
rs1369690708 135 dbSNP
rs911782966 136 dbSNP
rs987510108 145 dbSNP
rs185884651 146 dbSNP
rs1026428711 154 dbSNP
rs973888968 157 dbSNP
rs958507815 161 dbSNP
rs1424907163 164 dbSNP
rs151095379 169 dbSNP
rs1157012011 172 dbSNP
rs1023143306 183 dbSNP
rs1431553479 185 dbSNP
rs1466511843 193 dbSNP
rs1470550601 202 dbSNP
rs747621178 204 dbSNP
rs1357733850 215 dbSNP
rs1208337957 223 dbSNP
rs1008105248 227 dbSNP
rs953516611 228 dbSNP
rs1013054320 236 dbSNP
rs572186738 237 dbSNP
rs997580960 240 dbSNP
rs778752693 242 dbSNP
rs145516262 254 dbSNP
rs1310422652 258 dbSNP
rs1036329375 262 dbSNP
rs1251730420 263 dbSNP
rs139987753 267 dbSNP
rs1006241163 300 dbSNP
rs1180295378 300 dbSNP
rs574388415 309 dbSNP
rs754943650 320 dbSNP
rs1423648573 329 dbSNP
rs1412196058 330 dbSNP
rs1042170939 332 dbSNP
rs1171548577 333 dbSNP
rs1354329974 355 dbSNP
rs1428636622 358 dbSNP
rs1305836366 360 dbSNP
rs1366842336 365 dbSNP
rs556200422 384 dbSNP
rs753585169 394 dbSNP
rs1010607259 398 dbSNP
rs1295937809 401 dbSNP
rs1365624420 406 dbSNP
rs867503077 416 dbSNP
rs1203225444 420 dbSNP
rs893524114 428 dbSNP
rs1490586041 433 dbSNP
rs1221839281 439 dbSNP
rs1245117733 454 dbSNP
rs1455306438 459 dbSNP
rs937965056 459 dbSNP
rs1038858079 470 dbSNP
rs1392350454 476 dbSNP
rs1163367130 489 dbSNP
rs1419207178 492 dbSNP
rs1448073164 496 dbSNP
rs1165920663 508 dbSNP
rs1367021825 511 dbSNP
rs926455792 513 dbSNP
rs537815481 514 dbSNP
rs1046239903 515 dbSNP
rs1456923622 517 dbSNP
rs1347612600 527 dbSNP
rs1432756120 533 dbSNP
rs570381573 537 dbSNP
rs1364432335 557 dbSNP
rs1225860208 559 dbSNP
rs949111336 564 dbSNP
rs1360423847 568 dbSNP
rs1182249153 580 dbSNP
rs1451791201 585 dbSNP
rs1287735110 594 dbSNP
rs779875516 599 dbSNP
rs1448849349 600 dbSNP
rs558476102 604 dbSNP
rs911839597 610 dbSNP
rs768545353 611 dbSNP
rs539673725 615 dbSNP
rs1052103777 618 dbSNP
rs1463969362 622 dbSNP
rs1185793566 626 dbSNP
rs566259694 636 dbSNP
rs1444792124 641 dbSNP
rs181961855 645 dbSNP
rs957734791 653 dbSNP
rs547616866 675 dbSNP
rs189301276 676 dbSNP
rs1159243049 680 dbSNP
rs1387810543 684 dbSNP
rs1432884845 688 dbSNP
rs1338393390 692 dbSNP
rs986395824 720 dbSNP
rs1447522967 722 dbSNP
rs963464003 734 dbSNP
rs1353173213 739 dbSNP
rs184467032 747 dbSNP
rs1489606511 748 dbSNP
rs1030489822 749 dbSNP
rs75657203 752 dbSNP
rs991673854 759 dbSNP
rs1461161427 762 dbSNP
rs1185928650 782 dbSNP
rs1289556977 784 dbSNP
rs10749856 792 dbSNP
rs531564090 797 dbSNP
rs1006602465 801 dbSNP
rs1455516353 803 dbSNP
rs764070498 807 dbSNP
rs1428336198 808 dbSNP
rs192144933 810 dbSNP
rs1331997733 811 dbSNP
rs1021041461 814 dbSNP
rs376935591 815 dbSNP
rs546053211 819 dbSNP
rs1443217478 830 dbSNP
rs1287728862 849 dbSNP
rs147891058 859 dbSNP
rs893578138 864 dbSNP
rs1264276931 874 dbSNP
rs560283726 875 dbSNP
rs1385771143 880 dbSNP
rs1344969999 883 dbSNP
rs541615868 886 dbSNP
rs1038744109 892 dbSNP
rs1199089180 897 dbSNP
rs1275621652 900 dbSNP
rs574499640 902 dbSNP
rs1182086804 906 dbSNP
rs1363160915 907 dbSNP
rs1162283622 910 dbSNP
rs1250378162 913 dbSNP
rs1471337720 915 dbSNP
rs1201022245 917 dbSNP
rs1429873694 919 dbSNP
rs1477698569 923 dbSNP
rs1170584442 941 dbSNP
rs1398367289 944 dbSNP
rs1007378595 946 dbSNP
rs1307679311 951 dbSNP
rs758446643 954 dbSNP
rs1135260 960 dbSNP
rs1168389029 961 dbSNP
rs1135261 966 dbSNP
rs1135262 967 dbSNP
rs1051725766 968 dbSNP
rs796647210 970 dbSNP
rs1231726072 971 dbSNP
rs1272224778 973 dbSNP
rs1474604924 979 dbSNP
rs929217863 982 dbSNP
rs370719019 984 dbSNP
rs919148308 987 dbSNP
rs1273442480 988 dbSNP
rs1224071275 997 dbSNP
rs1037717679 998 dbSNP
rs1450892318 1001 dbSNP
rs1052181805 1009 dbSNP
rs1266848654 1014 dbSNP
rs941985988 1024 dbSNP
rs916020300 1025 dbSNP
rs144666772 1029 dbSNP
rs1426855337 1037 dbSNP
rs985820485 1041 dbSNP
rs932195199 1042 dbSNP
rs960267302 1043 dbSNP
rs574950999 1045 dbSNP
rs771104748 1048 dbSNP
rs976210435 1055 dbSNP
rs1275140767 1056 dbSNP
rs928791494 1063 dbSNP
rs1015543172 1064 dbSNP
rs1247741354 1069 dbSNP
rs1265471282 1071 dbSNP
rs1343186766 1072 dbSNP
rs984891792 1080 dbSNP
rs1263722305 1083 dbSNP
rs544261935 1086 dbSNP
rs1409864250 1087 dbSNP
rs1245977211 1089 dbSNP
rs765788945 1091 dbSNP
rs1164485458 1095 dbSNP
rs1019009537 1101 dbSNP
rs968049035 1104 dbSNP
rs796260698 1106 dbSNP
rs1008839483 1115 dbSNP
rs1001508429 1120 dbSNP
rs989132423 1125 dbSNP
rs957691348 1126 dbSNP
rs1408616167 1133 dbSNP
rs1017342454 1135 dbSNP
rs1007260885 1141 dbSNP
rs1173437997 1142 dbSNP
rs890173804 1150 dbSNP
rs1030588395 1154 dbSNP
rs1454200311 1174 dbSNP
rs1312956582 1177 dbSNP
rs905080102 1178 dbSNP
rs1241976260 1187 dbSNP
rs993315272 1191 dbSNP
rs897753521 1199 dbSNP
rs1477830565 1200 dbSNP
rs576887123 1202 dbSNP
rs77751965 1207 dbSNP
rs1024855052 1216 dbSNP
rs942038362 1217 dbSNP
rs1483410147 1219 dbSNP
rs1251039904 1221 dbSNP
rs1202349887 1222 dbSNP
rs1184066846 1223 dbSNP
rs867403774 1225 dbSNP
rs894470201 1226 dbSNP
rs1226230585 1229 dbSNP
rs71056321 1230 dbSNP
rs1055925644 1232 dbSNP
rs1199592926 1232 dbSNP
rs1409000244 1235 dbSNP
rs1319623193 1239 dbSNP
rs1321015411 1240 dbSNP
rs201390066 1241 dbSNP
rs199636400 1242 dbSNP
rs1349307895 1243 dbSNP
rs1377969585 1243 dbSNP
rs1308431365 1244 dbSNP
rs6690210 1244 dbSNP
rs1266144073 1245 dbSNP
rs367944812 1245 dbSNP
rs1440633925 1246 dbSNP
rs1361347126 1247 dbSNP
rs1020929576 1249 dbSNP
rs1175722870 1249 dbSNP
rs1180153059 1249 dbSNP
rs1197784734 1249 dbSNP
rs1252564329 1249 dbSNP
rs1255255025 1249 dbSNP
rs1370840287 1249 dbSNP
rs1432074082 1249 dbSNP
rs1434310525 1249 dbSNP
rs1472290850 1249 dbSNP
rs199546340 1249 dbSNP
rs758139168 1249 dbSNP
rs78627575 1249 dbSNP
rs1408657104 1250 dbSNP
rs938765573 1251 dbSNP
rs1335280701 1252 dbSNP
rs1219756462 1253 dbSNP
rs1300258433 1256 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucUCGUUCUGGGGCAGAGAuuu 5'
            :|::| |||||||||||   
Target 5' auGGUGAAACCCCGUCUCU--- 3'
9 - 27
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000396478.3 | 3UTR | UUGCCAACAUGGUGAAACCCCGUCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000396478.3 | 3UTR | UUGCCAACAUGGUGAAACCCCGUCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.565 2.0e-3 0.604 8.9e-4 24 Click to see details
GSE28260 Renal cortex and medulla 0.646 8.5e-3 0.560 2.3e-2 13 Click to see details
GSE42095 Differentiated embryonic stem cells -0.206 1.7e-1 -0.225 1.5e-1 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.164 2.2e-1 -0.202 1.7e-1 25 Click to see details
GSE38226 Liver fibrosis 0.156 2.5e-1 0.327 7.4e-2 21 Click to see details
GSE26953 Aortic valvular endothelial cells 0.097 3.3e-1 0.073 3.7e-1 24 Click to see details
GSE32688 Pancreatic cancer 0.046 4.0e-1 -0.052 3.9e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
186 hsa-miR-1303 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035871 SOAT1 sterol O-acyltransferase 1 1 1
MIRT035872 FHOD3 formin homology 2 domain containing 3 1 1
MIRT035873 RPL7A ribosomal protein L7a 1 1
MIRT035874 NCAPD2 non-SMC condensin I complex subunit D2 1 1
MIRT035875 RPS8 ribosomal protein S8 1 1
MIRT035876 AHNAK AHNAK nucleoprotein 1 1
MIRT035877 ACTB actin beta 1 1
MIRT035878 DEF8 differentially expressed in FDCP 8 homolog 1 1
MIRT035879 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT035880 MED13 mediator complex subunit 13 1 1
MIRT035881 FAT3 FAT atypical cadherin 3 1 1
MIRT035882 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT035883 RPS16 ribosomal protein S16 1 1
MIRT035884 CDK6 cyclin dependent kinase 6 1 1
MIRT035885 GEMIN5 gem nuclear organelle associated protein 5 1 1
MIRT035886 PITRM1 pitrilysin metallopeptidase 1 1 1
MIRT035887 PRRC2A proline rich coiled-coil 2A 1 1
MIRT035888 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 1 1
MIRT035889 MLLT6 MLLT6, PHD finger containing 1 1
MIRT035890 EIF3I eukaryotic translation initiation factor 3 subunit I 1 1
MIRT035891 FASN fatty acid synthase 1 1
MIRT035892 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT035893 HSCB HscB mitochondrial iron-sulfur cluster cochaperone 1 1
MIRT035894 PSME4 proteasome activator subunit 4 1 1
MIRT035895 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT035896 ZNF264 zinc finger protein 264 1 1
MIRT035897 HYLS1 HYLS1, centriolar and ciliogenesis associated 1 1
MIRT035898 USP54 ubiquitin specific peptidase 54 1 1
MIRT035899 L1TD1 LINE1 type transposase domain containing 1 1 1
MIRT035900 OR51E2 olfactory receptor family 51 subfamily E member 2 1 1
MIRT053762 CLDN18 claudin 18 3 1
MIRT060730 RPS3 ribosomal protein S3 2 2
MIRT083986 RAB22A RAB22A, member RAS oncogene family 2 2
MIRT098550 TBPL1 TATA-box binding protein like 1 2 6
MIRT134983 TWF1 twinfilin actin binding protein 1 2 4
MIRT136956 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT222065 PURB purine rich element binding protein B 2 2
MIRT239574 UBN2 ubinuclein 2 2 4
MIRT261820 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT264698 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT308476 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT377481 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT442304 NEU3 neuraminidase 3 2 2
MIRT446083 SLC30A10 solute carrier family 30 member 10 2 2
MIRT449606 PRPF4 pre-mRNA processing factor 4 2 2
MIRT453767 NUCB1 nucleobindin 1 2 10
MIRT455603 SRSF3 serine and arginine rich splicing factor 3 2 2
MIRT455913 KIF2C kinesin family member 2C 2 2
MIRT460091 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT460866 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461339 NUP133 nucleoporin 133 2 2
MIRT463769 YOD1 YOD1 deubiquitinase 2 2
MIRT466368 THAP1 THAP domain containing 1 2 4
MIRT467168 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468703 SDHD succinate dehydrogenase complex subunit D 2 2
MIRT469122 RNF126 ring finger protein 126 2 2
MIRT472426 NCBP2 nuclear cap binding protein subunit 2 2 4
MIRT479420 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT484260 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT485468 IL6ST interleukin 6 signal transducer 2 10
MIRT490237 H2AFZ H2A histone family member Z 2 6
MIRT491002 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT492127 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT499169 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499825 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT501794 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT503441 GINS4 GINS complex subunit 4 2 4
MIRT503688 MAVS mitochondrial antiviral signaling protein 2 5
MIRT506926 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT511430 HOXA10 homeobox A10 2 6
MIRT512415 LAYN layilin 2 4
MIRT513791 NIPAL3 NIPA like domain containing 3 2 4
MIRT516163 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 4
MIRT516513 PARK2 parkin RBR E3 ubiquitin protein ligase 2 2
MIRT516915 HINFP histone H4 transcription factor 2 2
MIRT517102 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517350 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT518019 ABHD15 abhydrolase domain containing 15 2 2
MIRT520945 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT525250 RNF213 ring finger protein 213 2 2
MIRT530634 PPIC peptidylprolyl isomerase C 2 4
MIRT530671 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531563 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT538205 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT538419 COLEC10 collectin subfamily member 10 2 2
MIRT541964 ZNF485 zinc finger protein 485 2 2
MIRT543088 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT543257 ZNF662 zinc finger protein 662 2 2
MIRT543589 KIAA1549 KIAA1549 2 2
MIRT543955 RNF20 ring finger protein 20 2 2
MIRT544043 C9orf64 chromosome 9 open reading frame 64 2 4
MIRT548064 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548240 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT548442 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548623 DAZAP1 DAZ associated protein 1 2 4
MIRT548770 COLEC12 collectin subfamily member 12 2 2
MIRT549506 HDDC2 HD domain containing 2 2 4
MIRT551924 AKAP8 A-kinase anchoring protein 8 2 4
MIRT555656 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT556286 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT557012 HOXD13 homeobox D13 2 4
MIRT563907 CLSPN claspin 2 2
MIRT565527 SON SON DNA binding protein 2 2
MIRT568000 COMMD2 COMM domain containing 2 2 2
MIRT569831 PLA2G16 phospholipase A2 group XVI 2 4
MIRT573905 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT616589 KLHL9 kelch like family member 9 2 2
MIRT617137 ZNF556 zinc finger protein 556 2 2
MIRT617400 API5 apoptosis inhibitor 5 2 2
MIRT617455 CCS copper chaperone for superoxide dismutase 2 2
MIRT617799 ZNF793 zinc finger protein 793 2 2
MIRT618190 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT618303 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT618329 ZNF813 zinc finger protein 813 2 2
MIRT618820 PHF20 PHD finger protein 20 2 2
MIRT619153 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619530 ZNF708 zinc finger protein 708 2 2
MIRT619849 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT620806 SLC26A2 solute carrier family 26 member 2 2 2
MIRT621312 YIPF4 Yip1 domain family member 4 2 2
MIRT621358 GUCA1B guanylate cyclase activator 1B 2 2
MIRT621366 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT621547 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT621883 TAOK1 TAO kinase 1 2 2
MIRT622451 RNF19B ring finger protein 19B 2 2
MIRT623404 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT623587 IPO9 importin 9 2 2
MIRT623974 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT624086 DPP8 dipeptidyl peptidase 8 2 2
MIRT624108 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT632486 RNF8 ring finger protein 8 2 2
MIRT634057 PLIN3 perilipin 3 2 2
MIRT634657 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT640682 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT641242 CENPN centromere protein N 2 2
MIRT642260 ZNF677 zinc finger protein 677 2 2
MIRT642954 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT644326 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT644632 ICA1L islet cell autoantigen 1 like 2 2
MIRT645721 POLR3A RNA polymerase III subunit A 2 2
MIRT647850 LYPLA1 lysophospholipase I 2 2
MIRT649281 NEK8 NIMA related kinase 8 2 2
MIRT650038 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT650354 RRP36 ribosomal RNA processing 36 2 2
MIRT651144 ZNF384 zinc finger protein 384 2 2
MIRT651778 UTP6 UTP6, small subunit processome component 2 2
MIRT652576 TLCD2 TLC domain containing 2 2 2
MIRT654621 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT656023 MYO5A myosin VA 2 2
MIRT656105 MSRB3 methionine sulfoxide reductase B3 2 2
MIRT657749 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT657924 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT658848 DUSP19 dual specificity phosphatase 19 2 2
MIRT659100 DENND6A DENN domain containing 6A 2 2
MIRT659153 DCX doublecortin 2 2
MIRT660870 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT661941 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT663577 C10orf32 BLOC-1 related complex subunit 7 2 2
MIRT664625 WDPCP WD repeat containing planar cell polarity effector 2 4
MIRT666562 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT669992 GPR156 G protein-coupled receptor 156 2 4
MIRT670445 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670853 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671942 SPPL3 signal peptide peptidase like 3 2 2
MIRT674269 LMOD3 leiomodin 3 2 2
MIRT674424 MIOX myo-inositol oxygenase 2 4
MIRT674982 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT675038 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT675309 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT675641 TTPAL alpha tocopherol transfer protein like 2 2
MIRT688688 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT689369 ZNF101 zinc finger protein 101 2 2
MIRT689605 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691715 LARS leucyl-tRNA synthetase 2 2
MIRT695473 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695530 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695878 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT696586 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT703007 HEATR5A HEAT repeat containing 5A 2 2
MIRT707942 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT709765 GPR183 G protein-coupled receptor 183 2 2
MIRT710332 ZNF669 zinc finger protein 669 2 2
MIRT713249 ZFP30 ZFP30 zinc finger protein 2 2
MIRT716613 RBM18 RNA binding motif protein 18 2 2
MIRT733414 BAG2 BCL2 associated athanogene 2 2 0
MIRT756135 THSD7A thrombospondin type 1 domain containing 7A 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1303 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-1303 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1303 Rituximab sensitive High Diffuse Large B-Cell Lymphoma cell line (DB, NU-DHL-1, NU-DUL-1, MC-116, SU-DHL-4, SU-DHL-5, FARAGE, HBL-1, OCI-Ly3, OCI-Ly7, OCI-Ly8, OCI-Ly19, RIVA, SU-DHL-8, U2932)
hsa-miR-1303 Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-mir-1303 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-1303 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1303 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1303 Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1303 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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