pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FBLIM1   
Synonyms CAL, FBLP-1, FBLP1
Description filamin binding LIM protein 1
Transcript NM_001024216   
Other Transcripts NM_001024215 , NM_017556   
Expression
Putative miRNA Targets on FBLIM1
3'UTR of FBLIM1
(miRNA target sites are highlighted)
>FBLIM1|NM_001024216|3'UTR
   1 GAGTGCCCGCTGGGCAGTGAACAGACCACTAGCCCCGGCTGGGGCCCTTCCCTGACTTGGTTTCCCTTCCTAACCTGCTC
  81 TTGCACACTTTCCTTCTGAGCCTCCATGGAGACCAGCCTGCAAGCCGGCCCAGCCTGTCCAGGATACAGTGGGGCTGAGC
 161 ACCCCCAGGCCTTCCACTCCTCTACCCTCTGGGCACCAGAAGGCTCCTGGACCATGAGCTTCACCCCCAGAATTCCCTGC
 241 TGACCCTGCCCCACTTCCAGGGAAAAGCTGGGGGAGGTTGGACCCCTCTCACTGACTAGCTGTCTGGTAGGGGTGCTAGG
 321 ACCAGCCTCGCCTGTGGGGTTGAGCTGTTTGAGGACAAACTCCAAGGTCCCTTAAAAAGTGCCTTTTAGAGGCTGGGCAT
 401 GGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCC
 481 TGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTAGCAGGTGCCTGTAATCCCAGC
 561 TACTGGGGAAAGCTGAGGCAGGAGAATTGCTTCAATCTGGAAGGCAGAGGTTGCAGTGAGATTGCACCATTGCATTCCAG
 641 CCTGGGCAACAAGAGGGAAACTCCGTCTCAAAAAAAAAAAAGTGCCTTTTAGGCCGGATGTGGTGGCTCATGCCTGTAAT
 721 CCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACGGCAAAACC
 801 CCGTTTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCA
 881 GGAGCATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATGGCACCACTGCACTCCAGCCTGGGAGACACAGC
 961 GAGACTCTGTCTCCAAAAAAAAAAGTGCTTTTTGAAAATGTTGAGGTTGAAATGATGGGAACCAACATTCTTTGGATTTA
1041 GTGGGGAGCATAATAGCAAACACCCCCTTGGTTCGCACATGTACAGGAATGGGACCCAGTTGGGGCACAGCCATGGACTT
1121 CCCCGCCCTGGAATGTGTGGTGCAAAGTGGGGCCAGGGCCCAGACCCAAGAGGAGAGGGTGGTCCGCAGACACCCCGGGA
1201 TGTCAGCATCCCCCGACCTGCCTTCTGGCGGCACCTCCCGGGTGCTGTGTTGAGTCAGCAGGCATGGGGTGAGAGCCTGG
1281 TATATGCTGGGAACAGGGTGCAGGGGCCAAGCGTTCCTCCTTCAGCCTTGACTTGGGCCATGCACCCCCTCTCCCCCAAA
1361 CACAAACAAGCACTTCTCCAGTATGGTGCCAGGACAGGTGTCCCTTCAGTCCTCTGGTTATGACCTCAAGTCCTACTTGG
1441 GCCCTGCAGCCCAGCCTGTGTTGTAACCTCTGCGTCCTCAAGACCACACCTGGAAGATTCTTCTTCCCTTTGAAGGAGAA
1521 TCATCATTGTTGCTTTATCACTTCTAAGACATTTTGTACGGCACGGACAAGTTAAACAGAATGTGCTTCCCTCCCTGGGG
1601 TCTCACACGCTCCCACGAGAATGCCACAGGGGCCGTGCACTGGGCAGGCTTCTCTGTAGAACCCCAGGGGCTTCGGCCCA
1681 GACCACAGCGTCTTGCCCTGAGCCTAGAGCAGGGAGTCCCGAACTTCTGCATTCACAGACCACCTCCACAATTGTTATAA
1761 CCAAAGGCCTCCTGTTCTGTTATTTCACTTAAATCAACATGCTATTTTGTTTTCACTCACTTCTGACTTTAGCCTCGTGC
1841 TGAGCCGTGTATCCATGCAGTCATGTTCACGTGCTAGTTACGTTTTTCTTCTTACACATGAAAATAAATGCATAAGTGTT
1921 AGAAGCTCTTCCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            | :|| ||    ||||||| 
Target 5' gcCTGGGCAACAAGAGGGAAAc 3'
640 - 661 148.00 -13.92
2
miRNA  3' cgguucccUUACCGUCCCUUUa 5'
                  | |  |||||||| 
Target 5' cctgccccACTTCCAGGGAAAa 3'
245 - 266 146.00 -11.20
3
miRNA  3' cgguucccuuaccGUCCCUUUa 5'
                       ::|||||| 
Target 5' taatcccagctacTGGGGAAAg 3'
551 - 572 125.00 -12.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26976073 4 COSMIC
COSN16128520 10 COSMIC
COSN29468757 10 COSMIC
COSN30188597 20 COSMIC
COSN508224 39 COSMIC
COSN13483853 65 COSMIC
COSN30451284 66 COSMIC
COSN1090976 70 COSMIC
COSN30175817 127 COSMIC
COSN28184333 155 COSMIC
COSN20094385 259 COSMIC
COSN20566092 275 COSMIC
COSN20120233 323 COSMIC
COSN6507867 565 COSMIC
COSN23934102 712 COSMIC
COSN23928857 715 COSMIC
COSN22113767 876 COSMIC
COSN26050966 1004 COSMIC
COSN7180736 1227 COSMIC
COSN15668233 1565 COSMIC
COSN23151462 1691 COSMIC
COSN1409296 1744 COSMIC
COSN7180738 1778 COSMIC
COSN25242612 1797 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1417030177 8 dbSNP
rs367784869 9 dbSNP
rs372175733 10 dbSNP
rs1457077311 14 dbSNP
rs201897060 15 dbSNP
rs776610060 19 dbSNP
rs753082392 20 dbSNP
rs1208145151 21 dbSNP
rs1348617337 22 dbSNP
rs759473158 26 dbSNP
rs769671656 27 dbSNP
rs957033784 30 dbSNP
rs537487970 34 dbSNP
rs762804307 35 dbSNP
rs557057387 36 dbSNP
rs368727367 37 dbSNP
rs200724462 38 dbSNP
rs1289870661 40 dbSNP
rs1250894137 41 dbSNP
rs767002938 43 dbSNP
rs749949218 45 dbSNP
rs1250931856 47 dbSNP
rs1479599531 48 dbSNP
rs1028456840 50 dbSNP
rs1178924875 51 dbSNP
rs1461948882 61 dbSNP
rs1191619785 64 dbSNP
rs1396415755 84 dbSNP
rs866234156 88 dbSNP
rs1434763227 92 dbSNP
rs953585606 100 dbSNP
rs986683101 106 dbSNP
rs1045937378 108 dbSNP
rs912048685 112 dbSNP
rs1299103993 118 dbSNP
rs766216610 125 dbSNP
rs186715423 127 dbSNP
rs146035281 128 dbSNP
rs573056336 130 dbSNP
rs1306239243 131 dbSNP
rs1448407430 132 dbSNP
rs898523646 138 dbSNP
rs1227748698 146 dbSNP
rs1293452535 147 dbSNP
rs1331609285 149 dbSNP
rs1309489681 151 dbSNP
rs1205442372 152 dbSNP
rs919296257 156 dbSNP
rs1025722992 158 dbSNP
rs191071990 161 dbSNP
rs563027487 168 dbSNP
rs1185440746 180 dbSNP
rs574813002 188 dbSNP
rs1429961765 189 dbSNP
rs1170646184 193 dbSNP
rs915950976 204 dbSNP
rs1256121262 215 dbSNP
rs1460202928 230 dbSNP
rs1328589100 231 dbSNP
rs1459139711 232 dbSNP
rs1199413481 240 dbSNP
rs1242698391 241 dbSNP
rs1430561561 243 dbSNP
rs1018737633 253 dbSNP
rs948599137 256 dbSNP
rs149301626 257 dbSNP
rs1292875799 259 dbSNP
rs1333973869 263 dbSNP
rs1415008173 263 dbSNP
rs1274748754 264 dbSNP
rs974702279 268 dbSNP
rs114521883 275 dbSNP
rs935706801 283 dbSNP
rs1486547858 286 dbSNP
rs988559207 287 dbSNP
rs1416700968 289 dbSNP
rs1426498183 290 dbSNP
rs765117666 305 dbSNP
rs912949505 311 dbSNP
rs1418979527 314 dbSNP
rs1400664314 316 dbSNP
rs949781912 328 dbSNP
rs998761688 335 dbSNP
rs1045907155 337 dbSNP
rs1052928931 340 dbSNP
rs906042710 342 dbSNP
rs1353808326 346 dbSNP
rs531087845 348 dbSNP
rs750211233 353 dbSNP
rs114298621 357 dbSNP
rs1028091551 360 dbSNP
rs1282025607 383 dbSNP
rs1318261743 384 dbSNP
rs564035612 399 dbSNP
rs1216724553 400 dbSNP
rs1304274514 401 dbSNP
rs953955258 407 dbSNP
rs1007966993 411 dbSNP
rs1258721094 412 dbSNP
rs1469921204 420 dbSNP
rs994162477 423 dbSNP
rs1410781229 426 dbSNP
rs1401734588 431 dbSNP
rs1173090340 432 dbSNP
rs1373664376 434 dbSNP
rs3180456 438 dbSNP
rs1019566623 439 dbSNP
rs533068776 442 dbSNP
rs1319921017 444 dbSNP
rs1219268063 445 dbSNP
rs1262615443 448 dbSNP
rs1310622393 449 dbSNP
rs1240737430 454 dbSNP
rs1212471689 455 dbSNP
rs1238316407 456 dbSNP
rs966199584 461 dbSNP
rs972310404 465 dbSNP
rs1485737591 470 dbSNP
rs1192031391 471 dbSNP
rs1265887791 472 dbSNP
rs546670918 473 dbSNP
rs1180122189 485 dbSNP
rs1234886880 489 dbSNP
rs1478440450 491 dbSNP
rs1170709885 494 dbSNP
rs1423823084 495 dbSNP
rs1412311461 498 dbSNP
rs1177779527 502 dbSNP
rs1359452244 505 dbSNP
rs566568611 519 dbSNP
rs952036389 527 dbSNP
rs1396059951 530 dbSNP
rs1296128833 533 dbSNP
rs139792929 537 dbSNP
rs915895087 542 dbSNP
rs1356013224 555 dbSNP
rs1400571167 560 dbSNP
rs948845071 562 dbSNP
rs1302552180 564 dbSNP
rs10803399 565 dbSNP
rs928474293 567 dbSNP
rs570595889 573 dbSNP
rs569162440 583 dbSNP
rs1221070852 596 dbSNP
rs537724585 614 dbSNP
rs1279593321 617 dbSNP
rs934461620 623 dbSNP
rs996481013 624 dbSNP
rs1251677007 631 dbSNP
rs1455681040 632 dbSNP
rs1199680302 644 dbSNP
rs1372536806 651 dbSNP
rs1474563402 654 dbSNP
rs1169851179 658 dbSNP
rs1214826398 661 dbSNP
rs1288626251 662 dbSNP
rs1488847334 665 dbSNP
rs1465944912 666 dbSNP
rs1442922210 670 dbSNP
rs200631185 670 dbSNP
rs1323676147 672 dbSNP
rs1199306455 676 dbSNP
rs111685220 678 dbSNP
rs201783689 678 dbSNP
rs28687583 678 dbSNP
rs56095235 678 dbSNP
rs140598663 679 dbSNP
rs957522162 686 dbSNP
rs1195689561 687 dbSNP
rs988434665 696 dbSNP
rs1245542739 697 dbSNP
rs1163947796 698 dbSNP
rs1415336281 712 dbSNP
rs1459398817 713 dbSNP
rs1163746360 715 dbSNP
rs1476754960 717 dbSNP
rs1383667363 722 dbSNP
rs1380021053 731 dbSNP
rs912918429 735 dbSNP
rs1340757789 741 dbSNP
rs1192436070 744 dbSNP
rs1291848697 745 dbSNP
rs1337383005 746 dbSNP
rs971106157 749 dbSNP
rs1260650473 750 dbSNP
rs1348706559 756 dbSNP
rs1425366188 757 dbSNP
rs183068183 762 dbSNP
rs1156570051 767 dbSNP
rs1362184106 772 dbSNP
rs570476027 773 dbSNP
rs1485483587 782 dbSNP
rs1186012119 784 dbSNP
rs539551643 792 dbSNP
rs755019100 793 dbSNP
rs1425300189 798 dbSNP
rs1442434875 801 dbSNP
rs1438618038 802 dbSNP
rs778872081 803 dbSNP
rs947308567 804 dbSNP
rs1159965276 814 dbSNP
rs186683992 828 dbSNP
rs1049893041 833 dbSNP
rs889452051 834 dbSNP
rs1354850995 837 dbSNP
rs1008433920 839 dbSNP
rs1357833982 843 dbSNP
rs1019319901 844 dbSNP
rs1306670791 845 dbSNP
rs1288271869 847 dbSNP
rs1241749546 848 dbSNP
rs1039017611 852 dbSNP
rs1347212336 867 dbSNP
rs572983220 874 dbSNP
rs993633781 876 dbSNP
rs1246815580 894 dbSNP
rs1484144944 899 dbSNP
rs1438583573 900 dbSNP
rs1249474175 904 dbSNP
rs189573796 910 dbSNP
rs1381842174 921 dbSNP
rs1440069173 923 dbSNP
rs1047028887 924 dbSNP
rs891139643 929 dbSNP
rs1008255627 931 dbSNP
rs1039815149 932 dbSNP
rs1394718373 936 dbSNP
rs1399618746 939 dbSNP
rs952296852 940 dbSNP
rs1370427489 947 dbSNP
rs1232160821 950 dbSNP
rs1444732960 956 dbSNP
rs552550682 961 dbSNP
rs142064350 962 dbSNP
rs1250599175 965 dbSNP
rs1244449919 966 dbSNP
rs1282817643 968 dbSNP
rs1238702411 969 dbSNP
rs1033259743 975 dbSNP
rs1467934498 975 dbSNP
rs957248630 975 dbSNP
rs1433430599 981 dbSNP
rs970079916 987 dbSNP
rs981941748 988 dbSNP
rs1169280859 989 dbSNP
rs928695814 990 dbSNP
rs934513753 999 dbSNP
rs1272985629 1002 dbSNP
rs1332695980 1004 dbSNP
rs1456919941 1005 dbSNP
rs1196283084 1007 dbSNP
rs575908292 1009 dbSNP
rs377098199 1020 dbSNP
rs1239543953 1032 dbSNP
rs1010169423 1043 dbSNP
rs1368369419 1051 dbSNP
rs77150923 1054 dbSNP
rs1305611817 1064 dbSNP
rs1220253783 1065 dbSNP
rs1258395743 1067 dbSNP
rs531368544 1075 dbSNP
rs564074378 1076 dbSNP
rs1049665101 1079 dbSNP
rs577759010 1081 dbSNP
rs34414640 1083 dbSNP
rs188363971 1087 dbSNP
rs943682150 1100 dbSNP
rs1171835609 1101 dbSNP
rs1460382558 1111 dbSNP
rs560323427 1114 dbSNP
rs1350609097 1119 dbSNP
rs367914308 1123 dbSNP
rs1287135872 1125 dbSNP
rs1401242444 1126 dbSNP
rs958708190 1128 dbSNP
rs1332487226 1129 dbSNP
rs566586500 1135 dbSNP
rs1226572491 1138 dbSNP
rs1291927868 1141 dbSNP
rs528960932 1143 dbSNP
rs1321854859 1158 dbSNP
rs993897727 1160 dbSNP
rs1258364297 1169 dbSNP
rs41268339 1171 dbSNP
rs1193871652 1173 dbSNP
rs1257308103 1176 dbSNP
rs1278116724 1186 dbSNP
rs887944286 1190 dbSNP
rs1415177754 1192 dbSNP
rs1006922836 1196 dbSNP
rs1216044023 1197 dbSNP
rs562511045 1197 dbSNP
rs970477973 1198 dbSNP
rs981442305 1199 dbSNP
rs1047332074 1203 dbSNP
rs912546614 1206 dbSNP
rs1354652900 1208 dbSNP
rs771228695 1215 dbSNP
rs1035636402 1216 dbSNP
rs1262190011 1218 dbSNP
rs531645387 1230 dbSNP
rs1253719057 1231 dbSNP
rs1306483218 1233 dbSNP
rs551217733 1235 dbSNP
rs1355187724 1238 dbSNP
rs571208306 1240 dbSNP
rs914447137 1241 dbSNP
rs947203806 1242 dbSNP
rs1040186459 1246 dbSNP
rs899873474 1250 dbSNP
rs1238374420 1253 dbSNP
rs1262317107 1255 dbSNP
rs1001373345 1258 dbSNP
rs1382285439 1264 dbSNP
rs985787083 1265 dbSNP
rs192646282 1270 dbSNP
rs893001782 1284 dbSNP
rs1335971645 1290 dbSNP
rs1359476216 1295 dbSNP
rs1441451569 1295 dbSNP
rs1329219755 1296 dbSNP
rs777126765 1297 dbSNP
rs943719972 1299 dbSNP
rs1040755108 1302 dbSNP
rs906860436 1303 dbSNP
rs1415333259 1313 dbSNP
rs185486458 1314 dbSNP
rs1437573303 1315 dbSNP
rs929744573 1324 dbSNP
rs1240561987 1331 dbSNP
rs1458562388 1338 dbSNP
rs1048170432 1342 dbSNP
rs887944962 1343 dbSNP
rs1006361931 1345 dbSNP
rs1393305211 1345 dbSNP
rs1479142450 1349 dbSNP
rs1173354785 1364 dbSNP
rs188197858 1367 dbSNP
rs906139300 1370 dbSNP
rs868026675 1371 dbSNP
rs566644220 1373 dbSNP
rs1409140404 1381 dbSNP
rs974243815 1385 dbSNP
rs1402376888 1392 dbSNP
rs868254371 1394 dbSNP
rs746370363 1399 dbSNP
rs1003067560 1405 dbSNP
rs1027142620 1408 dbSNP
rs951573797 1420 dbSNP
rs1402428742 1430 dbSNP
rs1279427040 1435 dbSNP
rs1275074252 1436 dbSNP
rs982994466 1438 dbSNP
rs553163818 1439 dbSNP
rs1217202755 1444 dbSNP
rs1260324490 1454 dbSNP
rs535542662 1455 dbSNP
rs1213563475 1459 dbSNP
rs1265419674 1460 dbSNP
rs555935764 1461 dbSNP
rs1199923357 1464 dbSNP
rs116795094 1468 dbSNP
rs1010281653 1473 dbSNP
rs192555396 1474 dbSNP
rs968968300 1475 dbSNP
rs1211276532 1480 dbSNP
rs1425437830 1481 dbSNP
rs533619584 1486 dbSNP
rs1466117997 1498 dbSNP
rs1164086755 1504 dbSNP
rs1388027358 1507 dbSNP
rs1406591768 1510 dbSNP
rs143529188 1515 dbSNP
rs1487209486 1518 dbSNP
rs1397708110 1520 dbSNP
rs936755445 1528 dbSNP
rs751889956 1559 dbSNP
rs369103567 1560 dbSNP
rs1263890692 1561 dbSNP
rs1359009620 1562 dbSNP
rs1210514176 1563 dbSNP
rs184780159 1565 dbSNP
rs375405505 1566 dbSNP
rs1478021044 1568 dbSNP
rs1041580023 1570 dbSNP
rs1366662863 1578 dbSNP
rs1379529370 1578 dbSNP
rs770387159 1584 dbSNP
rs114753107 1587 dbSNP
rs918293922 1591 dbSNP
rs1417535732 1593 dbSNP
rs894162419 1600 dbSNP
rs1361648892 1601 dbSNP
rs1414564033 1607 dbSNP
rs761448793 1609 dbSNP
rs1026732249 1610 dbSNP
rs1246103928 1613 dbSNP
rs560164683 1617 dbSNP
rs951542749 1618 dbSNP
rs1219149013 1627 dbSNP
rs982881580 1629 dbSNP
rs909609875 1630 dbSNP
rs947779259 1635 dbSNP
rs767253958 1636 dbSNP
rs906020809 1638 dbSNP
rs7663 1640 dbSNP
rs1188141100 1643 dbSNP
rs1332425978 1645 dbSNP
rs760507559 1652 dbSNP
rs1160146495 1655 dbSNP
rs989572118 1671 dbSNP
rs766094193 1675 dbSNP
rs373004363 1676 dbSNP
rs1404770537 1685 dbSNP
rs1397160777 1686 dbSNP
rs1022143542 1690 dbSNP
rs151169017 1691 dbSNP
rs562708724 1692 dbSNP
rs1347472127 1702 dbSNP
rs1231277287 1703 dbSNP
rs1254079749 1708 dbSNP
rs531456100 1721 dbSNP
rs1018140546 1722 dbSNP
rs894140748 1726 dbSNP
rs41268341 1732 dbSNP
rs754859300 1737 dbSNP
rs548382662 1755 dbSNP
rs951045893 1759 dbSNP
rs188376606 1769 dbSNP
rs1466858141 1770 dbSNP
rs1170336959 1771 dbSNP
rs1398748019 1773 dbSNP
rs527552636 1773 dbSNP
rs1449607541 1777 dbSNP
rs180979086 1778 dbSNP
rs1368354169 1780 dbSNP
rs1456870838 1788 dbSNP
rs752746182 1794 dbSNP
rs1313796825 1803 dbSNP
rs1233724224 1804 dbSNP
rs1003928973 1805 dbSNP
rs1316014107 1819 dbSNP
rs1392231911 1835 dbSNP
rs758524830 1837 dbSNP
rs777928672 1838 dbSNP
rs139116393 1843 dbSNP
rs1433346716 1846 dbSNP
rs1193440967 1847 dbSNP
rs747233889 1848 dbSNP
rs938820598 1852 dbSNP
rs1241973864 1854 dbSNP
rs1057330666 1856 dbSNP
rs1307467669 1860 dbSNP
rs965951193 1862 dbSNP
rs1295306713 1871 dbSNP
rs34025793 1872 dbSNP
rs1399580054 1878 dbSNP
rs2546 1882 dbSNP
rs958321145 1883 dbSNP
rs41268343 1885 dbSNP
rs904512998 1900 dbSNP
rs1311730157 1913 dbSNP
rs41269145 1916 dbSNP
rs966756477 1917 dbSNP
rs3177138 1923 dbSNP
rs1178102423 1924 dbSNP
rs982222142 1927 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccUUACCGUCCCUUUa 5'
                  || | ::|||:|: 
Target 5' -------aAAAGCUGGGGGAGg 3'
1 - 15
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000375771.1 | 3UTR | AAAAGCUGGGGGAGGUUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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