pre-miRNA Information
pre-miRNA hsa-mir-4301   
Genomic Coordinates chr11: 113450023 - 113450088
Description Homo sapiens miR-4301 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4301
Sequence 11| UCCCACUACUUCACUUGUGA |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs184176277 2 dbSNP
rs1191324913 13 dbSNP
rs1369198005 15 dbSNP
rs1036973189 16 dbSNP
rs944900541 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SPIN3   
Synonyms SPIN-3, TDRD27, bA445O16.1
Description spindlin family member 3
Transcript NM_001010862   
Expression
Putative miRNA Targets on SPIN3
3'UTR of SPIN3
(miRNA target sites are highlighted)
>SPIN3|NM_001010862|3'UTR
   1 AGGTCATCTTGAAATTTGCCAAATATATGAGACTCTAAATCTGTAGACACAGAAAGTCTTGATTGCTTTCCAGTTTGTAA
  81 GAACCATCTTCTCCCTTTTTGCACGTTTTGCTTGGCAAAAAAATTGGAACTTCTGCCCTCTCATACGTTTTTGGAAGAAA
 161 CCTTTTGCCCATCTGTCCAACCTTTTCACTGGTTCCTCTCCGCAATTTAACTGATTAGTGAGAAGGGTAAAGTCTGACAT
 241 CCATTGGCTCATACTTTTTTTTATCTTGGGTGGTGTTAATAGATTAAAGGTAGCTGAACACCTCTCACCTCACTCTTTTT
 321 GGCACTTGGACTCTACACTCATTGAGGTGTGAAGCTTGCTGAGATATCCCATGTGACTGGCTGGGTAAGTGTCTTTGCAA
 401 TCTCAAATCTCCCCCAAGTGGCTTCAAAAATCTAACTTGGGAAAGAGTGGGAAGCCCATTTTGGTCTCTTGTTCAAGTTG
 481 CATTCTCAGTTCTAACTGTACTAAAAGTAAGGCTAATAATTTTGCTCTCTTTCCGGTTCTTTCACCTATTGCTCAACTGT
 561 TTTAGAATTAAGAAGGTAATTACTTTGCATTTTAGTACCTAACCATAGGCTGAGAAACCTTGCAAAACTGATAAGAAGAC
 641 AAGCATTTGGGGACCAAACTCCAAGTGGAGAGATCAAGATTTCTGGTGGAGCTTAAGTGAAAGGTTTTAGTCATCAGTGG
 721 CATTAGGGTCTCTCTTGTCTCCAATAGCTCTGGCTGGTATCTGCAGACATGGAGTAGGTTTTAACTGATAGAAGCTGTGC
 801 AGGCAGACTTTAGCACAAATGGTCTTTGCCAGCCCAGAGGAGCATTAAGCCAGGCTCTAGCTAGAGCCCTCAGTCACAGG
 881 CAAAGGCTGGGTTTGGCTGGGTTTGGACAGATCTGTCCAGAACCTCAAAATGAAAGAGGAGAAACCTAGAATCAAACTGA
 961 GATACAGATTTCTTTGCTGTGCTAAGAGAGACTCAAGTTTTAGATTTGATTCTTAGGAGACTGAATTCAGAGTCCCAGCA
1041 TGTGAGGTGGGCAAGGCACTTGTGAGAACCAAGAATGGCTGAAAGCAGGCTATACTTCCTTGCAGGGACTGGTGGGCTCA
1121 TCTATTATGGTATCCCAGCAGGACTTGGAACACAGTCAGTGGTAGGTAATCTGTAGGCTTAATGATGTTTTAAGTGCTGG
1201 CATTGGTAGATAGAAATCTAATAGATTTTTGTTAGTGTTTGGATTTTTAACTATCCTGTTTCTTGGCTGGCCCTAAGAAA
1281 CTTATATGCAGATAAGGGTGAGTTCTACTGTGGCAGAAAAGTAAACAATGGAAGGGCCTTTGAGCTTTCCATTATTAAAG
1361 AGCCATTGGCGGAGGTTAACCAAAGCCTAGGAAAGAAAAGTTGAAGTACAAGCATGGTTTTTGAGAGAAGCACCTGGCCA
1441 AAACCAAAGCTTTCTCATTGAGGTTCTCACAGAAGCTCCATTAGCAGTAACAGCCTAATAAGGCCATGGAGTTCTGCACA
1521 TTTGGGGCTGGGACTCAAGGCAGTACAATCATATTGGGACTGTACTGCAAGATATCTTCCAAATTAGTTTAAGTTCACAG
1601 GTCATGGAGTCCAGACTACCGGCACAGATTGGCATCCTGCTGAGGATGAAACAAAGAAGATGTTCTCTTTTCTCCTATGT
1681 TTTATCTGTCTACTTTTGCTTTTTGATGCCACTAAGTCTCTACTATGATGTTTGACTGACAACAGCAATGTGGGTCTGTA
1761 TTGCCCTATGTTCTAAGTCCTGGGGTCATATATTTGCTTAAAAAAACTGTTCTAGTGGCTGGGGACTAGTGTGCTTTCTA
1841 ATTTTTTTGATGTGAGGTTGATATTGTGATAATCTTATGTCTTCTTGACCCTTTGGACTCTTTAATATGTATGACATGCA
1921 ATTGTGGGGTTAGATTAATTCAACTCCTGAGGTCCTGAAGGAACTTCACCCAGTCAAGAGGAAGACAGCCAAGGCTGCAG
2001 CTGCTGAAGGAACCCCATATCTGGGCAGACATCTTTGTGAGATCTATATGGCTGAAATGAGAAAAACGAGAAATTGGGAA
2081 AGGCAGAATTTTGGACTTTAATTATTTTGGACTTTGAATTAGAAATTTAATTTTGGGCAGTCCTTTTTCCCTTGGAGTTT
2161 AATAGTTGATGGGGTGGGGGTGAGGTCATATAGTTCAAACTAAGGCATTTTTATTATGTTGTTGATATTGTATTATTTGG
2241 AGTATTTTAATGCTATCTTTGGGAGTCATTGTATAATTGTTGTCAGCTATGTCAGGAAATATGGCTGGACATAATTGTAA
2321 ATTAGGGCTGCAATTGTGATCAAATTTTCAGTCTAGGGTGTAATGTAGCCTTAGAGTTAATTTAATTACTGTTCTATTTT
2401 GACTTATTTCAGAGCCTCTTGGGGGCAAAAACAACTGCTCACCAATCTTACATTGATGGGAGCAGAACTTTTCTAAGATA
2481 CTGTTGGTCTCCCTGGAAGGGGACAGCCACAGCCCTGTTTGTTGACCAGAGTCTTGAGCATTAACCATTGTGGCTTAAGA
2561 GAATGAAAATGTACAAGGGTATGATGGGATCTATCCTCTTCCTCTCTCCATGCTCCTGACTCAAGAAAAGGAAAAGACTT
2641 GCATCTCTCAAAAATGTTTGGAAGAAAGTTCTACCCATCTTCTCTTACACTCATTCAATCTTATGCTTGGGAGGAGGAAT
2721 AACTTGATGAGATTGAGAAAATGGTTATAATGGATAGGCAGCTTAGGCCACTCTTGGATCTTGAGTTCGTTCCACACAGC
2801 AAGATGTGGGAAAGACTGCAGTCCTTCACTACATGGCTGGGTAAACATCTGCTTTCTAGACCCAACTATCTCTCCTTGGG
2881 GTGGGGGAATCCCAAAGTCGTTAGACTTATGATAGAAGTTCATTTCAGCCTCAGGTCCAAGCCATGTTCTCCAATCCAGC
2961 TCTATCAGCTATAAAGCTGGTATCTATTTTGATTCTTTTTTACAGTTTTAATATATAAATTGTTTTTTAGAAAAATAACA
3041 CATGCCTATGGTAAAAGTCAAACAGTATAAAAGGGTATACTATTAAAAAGTAAGTCTCTCTTCCTCCTTCTCACCCCTGG
3121 CCTCAGTTCCCTGGTCCCATTTTCAAAAAGTAACAACTGTTACCAGTTACTGATGTATCATTCCAGAGATATTCCATGTA
3201 TTTACAAGCATATTGTGTGTGGGTATGTGTGTATCAGGTTTTTTTTTTTTTTTTACACAAATGGTGGCATACTATACATG
3281 CTGTTCTGAATTTTGCTTTTTTCACTGAACAATATATTAAAGCTGATATCTTAATCCCTAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aguguUCACUUCAUCACCCu 5'
               || |:| |:||||| 
Target 5' cttgcAG-GGACTGGTGGGc 3'
1099 - 1117 134.00 -13.70
2
miRNA  3' agUGUUCACUUCAUCACCcu 5'
            | || ||   ||||||  
Target 5' aaAAAACTGTTCTAGTGGct 3'
1801 - 1820 130.00 -5.50
3
miRNA  3' agUGUUCACUUCAUCACCCu 5'
            ||  | |||  |||||| 
Target 5' taACTTGGGAAAGAGTGGGa 3'
433 - 452 126.00 -14.80
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1320598591 2 dbSNP
rs1199870113 8 dbSNP
rs1479914332 29 dbSNP
rs904993132 38 dbSNP
rs770276965 49 dbSNP
rs746241308 51 dbSNP
rs757539478 52 dbSNP
rs752605297 55 dbSNP
rs900325012 66 dbSNP
rs1156850319 67 dbSNP
rs1038869483 77 dbSNP
rs1013457355 79 dbSNP
rs892205235 86 dbSNP
rs1464133518 87 dbSNP
rs1180726098 90 dbSNP
rs1248418870 92 dbSNP
rs1415083098 93 dbSNP
rs1478743244 99 dbSNP
rs1418358474 105 dbSNP
rs1210302537 113 dbSNP
rs1407945110 115 dbSNP
rs1335941981 117 dbSNP
rs1359921038 130 dbSNP
rs1052205368 136 dbSNP
rs1311112083 138 dbSNP
rs944595384 140 dbSNP
rs903528985 142 dbSNP
rs766393513 143 dbSNP
rs1278060775 146 dbSNP
rs1338025806 146 dbSNP
rs186414056 147 dbSNP
rs1279812571 148 dbSNP
rs1442622000 149 dbSNP
rs1209756263 152 dbSNP
rs1254765744 163 dbSNP
rs759597535 174 dbSNP
rs1193769230 180 dbSNP
rs911816493 190 dbSNP
rs943620311 192 dbSNP
rs771781014 201 dbSNP
rs1228792989 202 dbSNP
rs1414119569 203 dbSNP
rs1172071863 205 dbSNP
rs910844231 213 dbSNP
rs1357164690 214 dbSNP
rs1285985188 220 dbSNP
rs987592630 227 dbSNP
rs1364654591 237 dbSNP
rs988788969 238 dbSNP
rs1321449043 244 dbSNP
rs183567548 247 dbSNP
rs933520494 250 dbSNP
rs1277674492 251 dbSNP
rs926009883 255 dbSNP
rs1216652545 257 dbSNP
rs533572753 259 dbSNP
rs978823766 262 dbSNP
rs1200998768 263 dbSNP
rs1323538707 263 dbSNP
rs762373964 271 dbSNP
rs1191521847 290 dbSNP
rs772724964 301 dbSNP
rs970160301 316 dbSNP
rs963384389 321 dbSNP
rs1165590073 358 dbSNP
rs1016688561 367 dbSNP
rs1023110711 371 dbSNP
rs1331043768 380 dbSNP
rs968000141 386 dbSNP
rs1439073980 393 dbSNP
rs1311958666 399 dbSNP
rs1378592002 416 dbSNP
rs993015494 418 dbSNP
rs1390469241 431 dbSNP
rs969699878 439 dbSNP
rs1325856 489 dbSNP
rs1347998869 500 dbSNP
rs1211125835 502 dbSNP
rs1290424460 508 dbSNP
rs1468006038 509 dbSNP
rs1211542341 517 dbSNP
rs1239832674 525 dbSNP
rs1440522535 529 dbSNP
rs1016270207 534 dbSNP
rs1004504784 535 dbSNP
rs1467006477 545 dbSNP
rs1362119383 548 dbSNP
rs1473782799 565 dbSNP
rs1163910473 588 dbSNP
rs1390595441 591 dbSNP
rs1460358470 593 dbSNP
rs1245860806 605 dbSNP
rs1401531774 609 dbSNP
rs1447047185 631 dbSNP
rs1222252877 640 dbSNP
rs761452561 642 dbSNP
rs1246304381 643 dbSNP
rs1284303394 648 dbSNP
rs1334046175 649 dbSNP
rs778399372 655 dbSNP
rs1259750731 672 dbSNP
rs1013405079 712 dbSNP
rs6612746 713 dbSNP
rs1027298753 717 dbSNP
rs1444372405 725 dbSNP
rs994532069 737 dbSNP
rs892321353 738 dbSNP
rs10521485 742 dbSNP
rs1474494826 746 dbSNP
rs1038819121 755 dbSNP
rs1008687314 756 dbSNP
rs1230858498 759 dbSNP
rs1424988945 769 dbSNP
rs747354976 772 dbSNP
rs778078193 785 dbSNP
rs903479345 786 dbSNP
rs756482558 804 dbSNP
rs934619533 806 dbSNP
rs1352068995 812 dbSNP
rs1327425427 814 dbSNP
rs1231362581 818 dbSNP
rs925934038 820 dbSNP
rs1051991170 826 dbSNP
rs1428625815 834 dbSNP
rs780424991 836 dbSNP
rs1249425318 845 dbSNP
rs1347368393 848 dbSNP
rs1170114693 852 dbSNP
rs1201285776 853 dbSNP
rs1256891410 863 dbSNP
rs1484699622 878 dbSNP
rs919440389 885 dbSNP
rs1264480315 896 dbSNP
rs1428466457 899 dbSNP
rs1168752591 907 dbSNP
rs1379775770 908 dbSNP
rs1467259961 909 dbSNP
rs948760540 911 dbSNP
rs1424206017 913 dbSNP
rs1173945520 928 dbSNP
rs1191493923 930 dbSNP
rs1478878816 931 dbSNP
rs189766360 933 dbSNP
rs1412305379 948 dbSNP
rs764157687 952 dbSNP
rs1299529943 957 dbSNP
rs1362508132 972 dbSNP
rs1231169857 977 dbSNP
rs1381627269 983 dbSNP
rs1293135369 994 dbSNP
rs1233724240 1041 dbSNP
rs1332679148 1041 dbSNP
rs1204309721 1054 dbSNP
rs1482799443 1069 dbSNP
rs1275384461 1072 dbSNP
rs916002165 1072 dbSNP
rs1485811036 1085 dbSNP
rs1185359420 1092 dbSNP
rs1269902253 1094 dbSNP
rs753125458 1099 dbSNP
rs745992095 1102 dbSNP
rs1310594368 1116 dbSNP
rs1394057916 1119 dbSNP
rs1432498771 1126 dbSNP
rs960478721 1128 dbSNP
rs779129799 1144 dbSNP
rs1220237238 1148 dbSNP
rs909340168 1153 dbSNP
rs1287102768 1162 dbSNP
rs1369648262 1194 dbSNP
rs1259265372 1196 dbSNP
rs908751031 1199 dbSNP
rs1441314265 1203 dbSNP
rs983419248 1209 dbSNP
rs981164930 1215 dbSNP
rs757590943 1217 dbSNP
rs969437830 1224 dbSNP
rs1242642293 1231 dbSNP
rs1287054919 1236 dbSNP
rs1316477019 1238 dbSNP
rs1213757532 1249 dbSNP
rs1267679604 1261 dbSNP
rs1489109234 1273 dbSNP
rs1238999488 1289 dbSNP
rs1027246319 1291 dbSNP
rs994477985 1298 dbSNP
rs1024872627 1301 dbSNP
rs781226772 1303 dbSNP
rs1350601320 1305 dbSNP
rs1017316184 1306 dbSNP
rs1417934319 1321 dbSNP
rs992088089 1328 dbSNP
rs1351498310 1342 dbSNP
rs144284417 1344 dbSNP
rs890282286 1345 dbSNP
rs956490854 1351 dbSNP
rs1432492932 1365 dbSNP
rs1030841187 1369 dbSNP
rs1052988342 1370 dbSNP
rs778093983 1371 dbSNP
rs1222100830 1395 dbSNP
rs1314964431 1409 dbSNP
rs1336076353 1414 dbSNP
rs1233252725 1415 dbSNP
rs1271652552 1417 dbSNP
rs1415997865 1429 dbSNP
rs1199677850 1456 dbSNP
rs186230161 1458 dbSNP
rs903592698 1459 dbSNP
rs751302263 1463 dbSNP
rs1480119743 1468 dbSNP
rs1405495987 1478 dbSNP
rs904459319 1483 dbSNP
rs766245431 1484 dbSNP
rs1475493725 1490 dbSNP
rs1018052243 1497 dbSNP
rs1043040346 1498 dbSNP
rs180938242 1504 dbSNP
rs915949968 1511 dbSNP
rs1354103524 1524 dbSNP
rs1057237714 1531 dbSNP
rs1440350409 1532 dbSNP
rs749971647 1536 dbSNP
rs938805615 1540 dbSNP
rs751628967 1553 dbSNP
rs997733362 1559 dbSNP
rs766627253 1565 dbSNP
rs1291911908 1570 dbSNP
rs764698694 1572 dbSNP
rs897961187 1575 dbSNP
rs1272806407 1617 dbSNP
rs1306531088 1620 dbSNP
rs189746560 1621 dbSNP
rs761261018 1636 dbSNP
rs1238690902 1637 dbSNP
rs1019522328 1648 dbSNP
rs1485681689 1653 dbSNP
rs1186616055 1658 dbSNP
rs982981002 1659 dbSNP
rs1036488955 1661 dbSNP
rs942239321 1675 dbSNP
rs1408421677 1682 dbSNP
rs1317315120 1693 dbSNP
rs1178578238 1707 dbSNP
rs953051747 1714 dbSNP
rs776294212 1722 dbSNP
rs1311166880 1731 dbSNP
rs1377768900 1736 dbSNP
rs973008568 1740 dbSNP
rs1269975690 1741 dbSNP
rs763666451 1748 dbSNP
rs1360390416 1753 dbSNP
rs139730720 1769 dbSNP
rs948019082 1773 dbSNP
rs1348196890 1780 dbSNP
rs1209462503 1781 dbSNP
rs1386225167 1796 dbSNP
rs753871529 1797 dbSNP
rs775909715 1800 dbSNP
rs1193892842 1807 dbSNP
rs1457715850 1807 dbSNP
rs992037127 1807 dbSNP
rs987614727 1808 dbSNP
rs1005015475 1825 dbSNP
rs1192709780 1826 dbSNP
rs1414174540 1830 dbSNP
rs954498921 1841 dbSNP
rs1422180677 1849 dbSNP
rs186348309 1852 dbSNP
rs763930854 1857 dbSNP
rs998703080 1871 dbSNP
rs904409029 1875 dbSNP
rs746353092 1883 dbSNP
rs1362612219 1903 dbSNP
rs1021545899 1911 dbSNP
rs1401784832 1921 dbSNP
rs956606502 1922 dbSNP
rs774620353 1924 dbSNP
rs771160158 1927 dbSNP
rs1439008754 1934 dbSNP
rs760338658 1946 dbSNP
rs1012881039 1961 dbSNP
rs1300617683 1969 dbSNP
rs923888388 1980 dbSNP
rs775386471 1988 dbSNP
rs1283389341 1993 dbSNP
rs979662885 1994 dbSNP
rs967931378 2003 dbSNP
rs1018418901 2044 dbSNP
rs1453991644 2046 dbSNP
rs1006655689 2047 dbSNP
rs1057159267 2048 dbSNP
rs1247016360 2060 dbSNP
rs1470517341 2062 dbSNP
rs938734208 2067 dbSNP
rs1158104401 2068 dbSNP
rs1330233981 2084 dbSNP
rs1406366760 2094 dbSNP
rs1326955449 2099 dbSNP
rs1270617068 2103 dbSNP
rs1394289723 2108 dbSNP
rs1243222807 2110 dbSNP
rs1323406840 2114 dbSNP
rs1337167990 2131 dbSNP
rs1029288664 2135 dbSNP
rs1278468246 2137 dbSNP
rs1235132896 2143 dbSNP
rs1273568810 2169 dbSNP
rs1467822144 2174 dbSNP
rs1211597003 2177 dbSNP
rs887216755 2179 dbSNP
rs1320618735 2192 dbSNP
rs1047632848 2201 dbSNP
rs749341982 2206 dbSNP
rs12848142 2231 dbSNP
rs778147177 2236 dbSNP
rs993835406 2239 dbSNP
rs1231288855 2240 dbSNP
rs920127163 2249 dbSNP
rs898077262 2252 dbSNP
rs1319460239 2257 dbSNP
rs1435634913 2265 dbSNP
rs975633286 2276 dbSNP
rs1460143004 2282 dbSNP
rs1173315006 2287 dbSNP
rs1036647450 2301 dbSNP
rs1390529162 2311 dbSNP
rs1327597178 2312 dbSNP
rs1333537718 2317 dbSNP
rs756302116 2328 dbSNP
rs942978106 2332 dbSNP
rs771559947 2334 dbSNP
rs910190003 2338 dbSNP
rs987173346 2343 dbSNP
rs1252900880 2352 dbSNP
rs1340286643 2355 dbSNP
rs1195517056 2356 dbSNP
rs1248495371 2360 dbSNP
rs1486662549 2361 dbSNP
rs35191859 2364 dbSNP
rs1457306412 2390 dbSNP
rs1257384583 2401 dbSNP
rs1474526046 2411 dbSNP
rs1006775473 2415 dbSNP
rs954573053 2431 dbSNP
rs1367967935 2432 dbSNP
rs1374060841 2438 dbSNP
rs1462166893 2441 dbSNP
rs887972147 2457 dbSNP
rs1382400138 2460 dbSNP
rs780634175 2466 dbSNP
rs779898852 2472 dbSNP
rs977609912 2500 dbSNP
rs1425614279 2503 dbSNP
rs968538702 2513 dbSNP
rs1312979568 2515 dbSNP
rs948127409 2522 dbSNP
rs1388622431 2527 dbSNP
rs1297458670 2532 dbSNP
rs1021494536 2533 dbSNP
rs1012829203 2545 dbSNP
rs1249769855 2565 dbSNP
rs1350365592 2576 dbSNP
rs1056476517 2579 dbSNP
rs1279767766 2580 dbSNP
rs894408119 2586 dbSNP
rs1036073672 2609 dbSNP
rs758310604 2615 dbSNP
rs1263062182 2622 dbSNP
rs750380414 2625 dbSNP
rs935342656 2634 dbSNP
rs923841028 2641 dbSNP
rs1387880774 2644 dbSNP
rs1208613739 2657 dbSNP
rs759202208 2679 dbSNP
rs1455342153 2684 dbSNP
rs979385682 2689 dbSNP
rs765115446 2693 dbSNP
rs756760466 2700 dbSNP
rs1290503201 2704 dbSNP
rs886189560 2705 dbSNP
rs1246423424 2711 dbSNP
rs1339446124 2712 dbSNP
rs1381404686 2717 dbSNP
rs887155370 2720 dbSNP
rs1373441278 2727 dbSNP
rs1235352795 2731 dbSNP
rs866753679 2760 dbSNP
rs1302748955 2773 dbSNP
rs1047135158 2777 dbSNP
rs1345743787 2788 dbSNP
rs911058758 2789 dbSNP
rs931437247 2796 dbSNP
rs898649568 2799 dbSNP
rs181624113 2804 dbSNP
rs1203728929 2808 dbSNP
rs1255325374 2827 dbSNP
rs942931725 2830 dbSNP
rs1193940920 2846 dbSNP
rs1367131464 2858 dbSNP
rs912817809 2868 dbSNP
rs1430887439 2870 dbSNP
rs1029404019 2872 dbSNP
rs1386150646 2875 dbSNP
rs368850653 2879 dbSNP
rs1453030126 2884 dbSNP
rs1391430315 2894 dbSNP
rs1295213358 2897 dbSNP
rs987509049 2900 dbSNP
rs1396485820 2910 dbSNP
rs1441382397 2918 dbSNP
rs1325392645 2932 dbSNP
rs1365793857 2943 dbSNP
rs763712318 2944 dbSNP
rs993784407 2949 dbSNP
rs760370128 2957 dbSNP
rs1027380289 2960 dbSNP
rs977181730 2964 dbSNP
rs1368761439 2973 dbSNP
rs189089397 2980 dbSNP
rs1213467717 2983 dbSNP
rs1006477824 2994 dbSNP
rs1487315445 2998 dbSNP
rs914377937 3012 dbSNP
rs1250667007 3023 dbSNP
rs1418428242 3029 dbSNP
rs1450283472 3043 dbSNP
rs1156787584 3044 dbSNP
rs1419945605 3048 dbSNP
rs1375147662 3049 dbSNP
rs1023798476 3050 dbSNP
rs1163972241 3051 dbSNP
rs1012461020 3052 dbSNP
rs767898879 3058 dbSNP
rs1197130276 3075 dbSNP
rs1298810253 3082 dbSNP
rs1432955071 3090 dbSNP
rs1408097624 3096 dbSNP
rs1295583286 3100 dbSNP
rs1336153994 3102 dbSNP
rs896553937 3112 dbSNP
rs1288233546 3114 dbSNP
rs1268750303 3133 dbSNP
rs1212125120 3150 dbSNP
rs1206264278 3159 dbSNP
rs1251543015 3163 dbSNP
rs1479987795 3165 dbSNP
rs1056590642 3168 dbSNP
rs759771878 3172 dbSNP
rs775031267 3182 dbSNP
rs935290223 3193 dbSNP
rs771497861 3196 dbSNP
rs1411849959 3199 dbSNP
rs1171331093 3210 dbSNP
rs1035618565 3214 dbSNP
rs1354171885 3215 dbSNP
rs1003236058 3221 dbSNP
rs902529437 3224 dbSNP
rs1356638013 3238 dbSNP
rs200730167 3254 dbSNP
rs1202380243 3255 dbSNP
rs1282785321 3255 dbSNP
rs1321445478 3255 dbSNP
rs34237494 3255 dbSNP
rs368857775 3255 dbSNP
rs575535513 3255 dbSNP
rs796693849 3255 dbSNP
rs1281888569 3267 dbSNP
rs1485954139 3271 dbSNP
rs1253866441 3276 dbSNP
rs773416387 3277 dbSNP
rs1232343819 3279 dbSNP
rs1331440875 3284 dbSNP
rs1235680861 3287 dbSNP
rs368024081 3291 dbSNP
rs946661869 3297 dbSNP
rs1303381597 3303 dbSNP
rs1447946824 3313 dbSNP
rs1175565830 3314 dbSNP
rs1376211906 3328 dbSNP
rs911161008 3335 dbSNP
rs1026089078 3336 dbSNP
rs1347496562 3337 dbSNP
rs1431869144 3340 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' aguguuCACUUCAUCACCCu 5'
                | |||  |||||| 
Target 5' ---cuuGGGAAAGAGUGGGa 3'
1 - 17
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000374919.3 | 3UTR | CUUGGGAAAGAGUGGGAAGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4301 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081134 LDLR low density lipoprotein receptor 2 4
MIRT090911 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT229436 MECP2 methyl-CpG binding protein 2 2 2
MIRT274717 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT350957 BACH1 BTB domain and CNC homolog 1 2 2
MIRT386722 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT446022 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT481303 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 14
MIRT483959 ZNF354B zinc finger protein 354B 2 6
MIRT495667 TUBAL3 tubulin alpha like 3 2 2
MIRT496554 TBX15 T-box 15 2 2
MIRT497702 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT498105 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT512535 SEMA4D semaphorin 4D 2 2
MIRT512556 MFN2 mitofusin 2 2 6
MIRT521465 RABGAP1 RAB GTPase activating protein 1 2 6
MIRT526236 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526743 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527578 BRD7 bromodomain containing 7 2 4
MIRT528038 WT1 Wilms tumor 1 2 2
MIRT528267 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT528505 HTR7 5-hydroxytryptamine receptor 7 2 4
MIRT528758 RPS27 ribosomal protein S27 2 6
MIRT528999 IPO9 importin 9 2 2
MIRT529701 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529781 C17orf82 chromosome 17 open reading frame 82 2 2
MIRT533797 TMEM119 transmembrane protein 119 2 6
MIRT535308 PHF12 PHD finger protein 12 2 2
MIRT535917 MKL2 MKL1/myocardin like 2 2 2
MIRT544892 OSBPL1A oxysterol binding protein like 1A 2 2
MIRT555423 PPIC peptidylprolyl isomerase C 2 2
MIRT562068 KLHL15 kelch like family member 15 2 2
MIRT565623 SLC31A1 solute carrier family 31 member 1 2 2
MIRT565661 SIX1 SIX homeobox 1 2 2
MIRT570138 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT571045 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT621232 LMAN1 lectin, mannose binding 1 2 2
MIRT622272 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623844 GAN gigaxonin 2 2
MIRT626158 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626464 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT632087 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT637243 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT642710 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT643611 KANSL3 KAT8 regulatory NSL complex subunit 3 2 2
MIRT644270 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 2 2
MIRT645470 SPIN3 spindlin family member 3 2 2
MIRT649193 DNPEP aspartyl aminopeptidase 2 2
MIRT650776 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT651345 ZC2HC1C zinc finger C2HC-type containing 1C 2 2
MIRT652237 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT652587 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654591 PURA purine rich element binding protein A 2 2
MIRT654649 PTAFR platelet activating factor receptor 2 2
MIRT656842 KLF7 Kruppel like factor 7 2 2
MIRT657209 IKZF2 IKAROS family zinc finger 2 2 2
MIRT658513 ETV3 ETS variant 3 2 2
MIRT659448 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT668816 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT669067 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT677711 ELOF1 elongation factor 1 homolog 2 4
MIRT687146 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT698498 THOC2 THO complex 2 2 2
MIRT707930 PPP1R3D protein phosphatase 1 regulatory subunit 3D 4 2
MIRT708737 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT710031 POLL DNA polymerase lambda 2 2
MIRT712175 STK4 serine/threonine kinase 4 2 2
MIRT715297 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT716892 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT717378 RBM41 RNA binding motif protein 41 2 2
MIRT718082 CLIC5 chloride intracellular channel 5 2 2
MIRT718721 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT719152 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719224 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719528 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT719861 KLF2 Kruppel like factor 2 2 2
MIRT720326 CAMK2G calcium/calmodulin dependent protein kinase II gamma 2 2
MIRT721596 SREBF1 sterol regulatory element binding transcription factor 1 2 2
MIRT722020 NEBL nebulette 2 2
MIRT722484 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT722614 TEAD1 TEA domain transcription factor 1 2 2
MIRT723664 RPTN repetin 2 2
MIRT723939 SVOP SV2 related protein 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive High Hepatocellular Carcinoma cell line (Hep3B, 97L)
hsa-miR-4301 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-4301 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-4301 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-4301 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-miR-4301 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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