pre-miRNA Information
pre-miRNA hsa-mir-4680   
Genomic Coordinates chr10: 110898090 - 110898155
Description Homo sapiens miR-4680 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4680-5p
Sequence 5| AGAACUCUUGCAGUCUUAGAUGU |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1274530692 2 dbSNP
rs780271274 5 dbSNP
rs1461423681 7 dbSNP
rs749729920 8 dbSNP
rs1252920446 10 dbSNP
rs201739274 11 dbSNP
rs774971106 19 dbSNP
rs748132091 22 dbSNP
rs773643180 22 dbSNP
rs1235425484 23 dbSNP
Putative Targets

Gene Information
Gene Symbol ADK   
Synonyms AK
Description adenosine kinase
Transcript NM_001123   
Other Transcripts NM_006721   
Expression
Putative miRNA Targets on ADK
3'UTR of ADK
(miRNA target sites are highlighted)
>ADK|NM_001123|3'UTR
   1 TGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAAAGAAG
  81 AAAATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAG
 161 AATCTTTATTATCTCAACAATCTAAAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAACAA
 241 GAATATAACATTTCAATAGAAATTTTTATTTCATTTTCAATTACTTTGTAAATTCGTGTGTATTTAGTACACTGATTTGT
 321 TTTTTTACATTTCTGCTTTGAATGCAGATGCAATTTAATATAATAGATTTTTTAATGAATTAATCTTAACATAGTAATCT
 401 TTAGCTTTTTATACAAATATATTTAATTTAGGAGTATATGTGTGTCTATACACACACATACATAAATATACCACATATAC
 481 ACCTGATAGTCAAATAAGGTACAGAAATTTTATCTTGTCAATTATGCCAAATAATCTCTTTAATGTGCACTCAAACATGT
 561 AATAAACTTTGGATAATTAAATAATGTGCCAAATTTAAGTTGTACCACAATATTCAAATCATAGTCTTATGGAACTCTGT
 641 AATTGGACACAAACAAAAACTTGTCATATAGGAATTTTTTTCTGTCTTTTCCCTGTGTACAGCAAACTGAGGAAGAAAGA
 721 TCATTATTTAATACTGGGCCCTGAAATGACACCCAATTTGTTAATGGAATTATGAAGAACAGCAATATAATACACTGAAG
 801 AATAACTTAGTATCAGAGACCAATAAATCACTTTTTTAAGGATGACAAAATGGTATAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugUAGAU-UCUGACGUUCUCAaga 5'
            ||:|| ||: | ||||:||   
Target 5' taATTTAGAGGGTACAAGGGTatg 3'
124 - 147 117.00 -10.42
2
miRNA  3' uguagaUUCUGACGUUCUCAAGa 5'
                ||| |  ||:|||| | 
Target 5' aaacacAAGCC--CAGGAGTGCa 3'
13 - 33 109.00 -6.80
3
miRNA  3' ugUAGAUUCUGACGUUCUCAaga 5'
            ||:|||   | :|:||||   
Target 5' atATTTAA---TTTAGGAGTata 3'
419 - 438 106.00 -6.32
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
877986 115 ClinVar
300844 158 ClinVar
877987 297 ClinVar
300845 338 ClinVar
877988 350 ClinVar
300846 376 ClinVar
300847 649 ClinVar
879453 730 ClinVar
300848 741 ClinVar
COSN30461977 54 COSMIC
COSN22211003 67 COSMIC
COSN30462791 72 COSMIC
COSN31566814 84 COSMIC
COSN31548822 103 COSMIC
COSN31521944 134 COSMIC
COSN31598997 201 COSMIC
COSN31522795 206 COSMIC
COSN31607278 296 COSMIC
COSN8189467 498 COSMIC
rs1189553 649 GWAS
rs150465356 741 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1234364651 2 dbSNP
rs201968419 3 dbSNP
rs1354754699 4 dbSNP
rs769358595 5 dbSNP
rs772794217 8 dbSNP
rs762543643 23 dbSNP
rs766056833 26 dbSNP
rs751513865 38 dbSNP
rs1248938503 41 dbSNP
rs759597400 42 dbSNP
rs778998467 47 dbSNP
rs1370106714 51 dbSNP
rs767295102 53 dbSNP
rs1232318175 54 dbSNP
rs952502617 57 dbSNP
rs1052039 59 dbSNP
rs549346039 68 dbSNP
rs1444305950 73 dbSNP
rs1264798491 94 dbSNP
rs1204039013 95 dbSNP
rs1453841659 103 dbSNP
rs541727814 108 dbSNP
rs984319311 109 dbSNP
rs560409958 115 dbSNP
rs1225024635 119 dbSNP
rs1373441429 131 dbSNP
rs1278370400 133 dbSNP
rs964808090 135 dbSNP
rs1439609029 139 dbSNP
rs976529213 144 dbSNP
rs908577734 153 dbSNP
rs886047237 158 dbSNP
rs552832469 160 dbSNP
rs1337857431 163 dbSNP
rs1469584602 181 dbSNP
rs1404611289 184 dbSNP
rs1401729865 193 dbSNP
rs940023377 193 dbSNP
rs1041113567 196 dbSNP
rs956496563 205 dbSNP
rs1243946681 214 dbSNP
rs988983550 218 dbSNP
rs1184050351 220 dbSNP
rs914760669 233 dbSNP
rs1260956193 245 dbSNP
rs901221128 246 dbSNP
rs1317400521 249 dbSNP
rs947527441 251 dbSNP
rs1044526892 257 dbSNP
rs1361201688 263 dbSNP
rs1315303526 288 dbSNP
rs1264655017 296 dbSNP
rs527621742 297 dbSNP
rs1290957284 301 dbSNP
rs545369910 304 dbSNP
rs1235585063 308 dbSNP
rs1345089708 309 dbSNP
rs1157058062 318 dbSNP
rs886047238 338 dbSNP
rs1000144682 343 dbSNP
rs1057210925 348 dbSNP
rs180766950 349 dbSNP
rs896781492 350 dbSNP
rs1177756645 368 dbSNP
rs185021662 376 dbSNP
rs1013886594 380 dbSNP
rs1157131642 381 dbSNP
rs1213119125 382 dbSNP
rs1360992255 390 dbSNP
rs1048315362 392 dbSNP
rs1470458015 396 dbSNP
rs1291784880 400 dbSNP
rs1244828664 406 dbSNP
rs1356762381 417 dbSNP
rs888351462 423 dbSNP
rs865792093 429 dbSNP
rs1361944766 432 dbSNP
rs1018118438 433 dbSNP
rs1287613406 439 dbSNP
rs970181886 443 dbSNP
rs1002393396 449 dbSNP
rs965192484 454 dbSNP
rs1302587031 456 dbSNP
rs1423002386 458 dbSNP
rs549477270 469 dbSNP
rs997574784 473 dbSNP
rs866612762 476 dbSNP
rs1374983730 479 dbSNP
rs1030748922 480 dbSNP
rs1172321903 481 dbSNP
rs1428893146 492 dbSNP
rs1418788063 499 dbSNP
rs1299264400 500 dbSNP
rs569308220 515 dbSNP
rs1490808465 516 dbSNP
rs1269003178 518 dbSNP
rs530342207 522 dbSNP
rs1034286181 531 dbSNP
rs118172189 548 dbSNP
rs1307303008 550 dbSNP
rs770273844 554 dbSNP
rs989035983 558 dbSNP
rs1021858501 562 dbSNP
rs776044168 565 dbSNP
rs1403149889 570 dbSNP
rs567141252 579 dbSNP
rs961367965 582 dbSNP
rs1398992318 604 dbSNP
rs977130497 606 dbSNP
rs1461611244 618 dbSNP
rs1323791926 625 dbSNP
rs922729843 627 dbSNP
rs932754404 634 dbSNP
rs1481404550 635 dbSNP
rs1189553 649 dbSNP
rs927452394 663 dbSNP
rs1439363260 664 dbSNP
rs938435264 667 dbSNP
rs992569705 669 dbSNP
rs935819535 671 dbSNP
rs891681703 673 dbSNP
rs1480086138 682 dbSNP
rs1256588922 687 dbSNP
rs1013939829 705 dbSNP
rs918263091 711 dbSNP
rs1221825353 723 dbSNP
rs929686638 726 dbSNP
rs1307744498 730 dbSNP
rs1391060734 733 dbSNP
rs1371426302 736 dbSNP
rs1048073707 737 dbSNP
rs905508430 738 dbSNP
rs1470829568 740 dbSNP
rs150465356 741 dbSNP
rs942587237 742 dbSNP
rs952885010 747 dbSNP
rs373509416 757 dbSNP
rs1181845484 758 dbSNP
rs1423441752 764 dbSNP
rs1235946705 766 dbSNP
rs1412029148 778 dbSNP
rs900964505 783 dbSNP
rs576760286 786 dbSNP
rs1370505731 793 dbSNP
rs1408602445 795 dbSNP
rs1242857938 805 dbSNP
rs562396817 807 dbSNP
rs751686986 808 dbSNP
rs977014428 809 dbSNP
rs1435244998 843 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugUAGAUUCUGACGUUCUCaaga 5'
            | :|:|| |  ||:|||    
Target 5' ucACUUGAGCC--CAGGAG---- 3'
14 - 30
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000372734.3 | 3UTR | CAAGGUGGGAGGAUCACUUGAGCCCAGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
133 hsa-miR-4680-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT378771 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT393867 ZDHHC21 zinc finger DHHC-type containing 21 2 4
MIRT446684 C2CD2 C2 calcium dependent domain containing 2 2 2
MIRT447600 MRPL3 mitochondrial ribosomal protein L3 2 2
MIRT450708 RNF152 ring finger protein 152 2 2
MIRT450784 PAPOLG poly(A) polymerase gamma 2 2
MIRT454623 COL23A1 collagen type XXIII alpha 1 chain 2 8
MIRT461620 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT462695 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT475530 HOXA3 homeobox A3 2 8
MIRT475739 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT489676 CYP1A1 cytochrome P450 family 1 subfamily A member 1 2 2
MIRT490610 SLC47A1 solute carrier family 47 member 1 2 2
MIRT493628 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT496152 RPS15A ribosomal protein S15a 2 2
MIRT499232 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT501496 PRICKLE2 prickle planar cell polarity protein 2 2 2
MIRT507163 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT512389 MTRNR2L1 MT-RNR2-like 1 2 4
MIRT514626 MTRNR2L7 MT-RNR2-like 7 2 2
MIRT517474 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT525332 CNGB1 cyclic nucleotide gated channel beta 1 2 2
MIRT526685 BAK1 BCL2 antagonist/killer 1 2 2
MIRT527317 CCR2 C-C motif chemokine receptor 2 2 2
MIRT527608 EYS eyes shut homolog (Drosophila) 2 2
MIRT528794 RAB32 RAB32, member RAS oncogene family 2 2
MIRT531048 TIPARP TCDD inducible poly(ADP-ribose) polymerase 2 2
MIRT532254 TBPL2 TATA-box binding protein like 2 2 2
MIRT533801 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT535887 MLEC malectin 2 2
MIRT540704 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT544645 PHF8 PHD finger protein 8 2 4
MIRT545760 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT555310 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 2
MIRT555877 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT559507 ARID5B AT-rich interaction domain 5B 2 2
MIRT560448 SLC30A7 solute carrier family 30 member 7 2 2
MIRT561262 ZIK1 zinc finger protein interacting with K protein 1 2 2
MIRT561795 PAWR pro-apoptotic WT1 regulator 2 2
MIRT567007 KLHL15 kelch like family member 15 2 2
MIRT569298 SURF6 surfeit 6 2 2
MIRT570606 MTRNR2L11 MT-RNR2-like 11 2 2
MIRT572888 ADCY2 adenylate cyclase 2 2 2
MIRT573119 ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 2 2
MIRT608332 ZNF670 zinc finger protein 670 2 6
MIRT614942 KCNK5 potassium two pore domain channel subfamily K member 5 2 2
MIRT615324 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT618441 ZNF800 zinc finger protein 800 2 2
MIRT620110 HARBI1 harbinger transposase derived 1 2 2
MIRT626008 ZNF517 zinc finger protein 517 2 2
MIRT626626 SLC30A6 solute carrier family 30 member 6 2 2
MIRT627842 POU3F1 POU class 3 homeobox 1 2 2
MIRT628386 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT629305 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT629864 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT630444 IDE insulin degrading enzyme 2 2
MIRT631854 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT633173 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT633477 ZNF724P zinc finger protein 724 2 2
MIRT634395 PLSCR1 phospholipid scramblase 1 2 2
MIRT635538 TRIM72 tripartite motif containing 72 2 2
MIRT635821 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT636169 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636797 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT637952 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT645136 HES2 hes family bHLH transcription factor 2 2 2
MIRT645667 ADK adenosine kinase 2 2
MIRT646148 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT647004 NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2 2
MIRT648187 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT650090 TERF2 telomeric repeat binding factor 2 2 2
MIRT650329 RTN2 reticulon 2 2 2
MIRT654224 RNF165 ring finger protein 165 2 2
MIRT654545 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT656457 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT656828 KLF8 Kruppel like factor 8 2 2
MIRT657112 ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein like 2 2 2
MIRT657930 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT659375 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT659833 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT662108 LACTB lactamase beta 2 4
MIRT662789 TBC1D25 TBC1 domain family member 25 2 2
MIRT669501 ARL3 ADP ribosylation factor like GTPase 3 2 2
MIRT669759 ZNF101 zinc finger protein 101 2 4
MIRT669800 GAN gigaxonin 2 2
MIRT670050 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670299 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670388 EMP2 epithelial membrane protein 2 2 2
MIRT672862 C22orf29 retrotransposon Gag like 10 2 2
MIRT672890 FXN frataxin 2 2
MIRT673210 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT674001 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674163 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674502 TIRAP TIR domain containing adaptor protein 2 2
MIRT675470 NUBPL nucleotide binding protein like 2 2
MIRT675671 TMOD2 tropomodulin 2 2 2
MIRT676006 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676074 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676386 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676764 SNX2 sorting nexin 2 2 2
MIRT676896 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT676978 ZNF708 zinc finger protein 708 2 2
MIRT677236 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677369 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT677464 PDLIM3 PDZ and LIM domain 3 2 2
MIRT678081 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678093 ATCAY ATCAY, caytaxin 2 2
MIRT678324 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678417 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678521 ZNF347 zinc finger protein 347 2 2
MIRT678700 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT678829 PDE6A phosphodiesterase 6A 2 2
MIRT679991 RUNDC1 RUN domain containing 1 2 2
MIRT680751 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT681249 ZNF383 zinc finger protein 383 2 2
MIRT681422 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT681948 SLC19A3 solute carrier family 19 member 3 2 2
MIRT689278 C5AR2 complement component 5a receptor 2 2 2
MIRT690389 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT691845 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT693863 IYD iodotyrosine deiodinase 2 2
MIRT696002 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT701930 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT702341 KLHL7 kelch like family member 7 2 2
MIRT703557 FKBP14 FK506 binding protein 14 2 2
MIRT705033 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT706341 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT709671 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT711212 EFHB EF-hand domain family member B 2 2
MIRT718342 PURA purine rich element binding protein A 2 2
MIRT722755 SIRPB2 signal regulatory protein beta 2 2 2
MIRT723535 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT724498 BFAR bifunctional apoptosis regulator 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4680-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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