pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol SLC35E4   
Synonyms -
Description solute carrier family 35 member E4
Transcript NM_001001479   
Expression
Putative miRNA Targets on SLC35E4
3'UTR of SLC35E4
(miRNA target sites are highlighted)
>SLC35E4|NM_001001479|3'UTR
   1 GACCTGGGGGATCTCAGGAGCCACCTGGGATGGCCCTGGCCTGAATCCAGCCTCCGCTGTGGCCATAGAAGGAATGGAGA
  81 ACAGGGCTGGGCATGGTGGCTCACGCCTATAATCCCAGCACTTCCAGAGTCCGAGGTGGGTGGATCACCTGAGGCCAGGA
 161 GTTCGAGACCAGCCTGGCTAACATGGCAAAACCTCATCTCTACTAAAAATAGAAAAATTAGCTGGGCATGGTGGCGCGTG
 241 CCTATAGTCCCAGCTACATGGGAGGCTAAGGTGGGAGGATCACTTGAGCCCTGGAGATCGAGGCTGCAGTAAGCCAAGAT
 321 CGCATGCTACTGCACTCCAGCCTGGGAGACAGAGCGAGACGCTGTCTCAATTAAAAAAAAAAAAAAGTGGAGAACTGGCA
 401 GTGACCTCTACTGGGGGCCATGGCAGGGAGGGGAGCCTTCTGGAAGGGCTGCCTTGGAGATTGGAATGGGGACTCCCAGG
 481 GAGACCTGCGTTCCATCCCTGCCTGCCTCACCCCTGCCACAGACTCTGCACACCACTGGATGGTGGGTCCAAGCCTGGCA
 561 CAGTCCCTGTGCTTGTCAGAGTCATTATTATGATTAATATCAATTACGATGCCAAAAATTGCTGGGCAAACTTTGAAGAC
 641 CTCAACTTGTTACAATGACGATGATGATGATTCTTGGCGGTTACACAATCCTTCCTCCTGGGGGGGAGGCAGCTAGGAGG
 721 CCCAGCAGGGGGGCTTCTATGCTGCTGGGCTCCCCTAGGGAGTTGGGGTAGTCTGTGCCAACTCCAGGCAGCTGCTGTGG
 801 CCTCACCCCTGGGCCCCCCAATTTTGGGTCATCCATCCTCAAATACACTATTTTTGCTTGTAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccccACCCCUGUCUCCGAa 5'
                ||| ||: |||||| 
Target 5' gagcccTGGAGATCGAGGCTg 3'
286 - 306 131.00 -13.60
2
miRNA  3' gaCCCCACCCCUGUCUCCGAa 5'
            ||| |||| |::| |||| 
Target 5' caGGGCTGGGCATGGTGGCTc 3'
82 - 102 127.00 -19.50
3
miRNA  3' gaccccaccccugUCUCCGAa 5'
                       :|||||| 
Target 5' tcccagctacatgGGAGGCTa 3'
248 - 268 124.00 -9.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28743652 11 COSMIC
COSN30119072 14 COSMIC
COSN30109349 17 COSMIC
COSN31550472 18 COSMIC
COSN30490869 37 COSMIC
COSN13910209 56 COSMIC
COSN28807923 100 COSMIC
COSN8566388 175 COSMIC
COSN1897165 266 COSMIC
COSN1897167 267 COSMIC
COSN21397655 272 COSMIC
COSN24042562 319 COSMIC
COSN20117366 387 COSMIC
COSN5455125 819 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs376598130 4 dbSNP
rs568884836 6 dbSNP
rs1417551039 11 dbSNP
rs1269601943 17 dbSNP
rs1326861347 18 dbSNP
rs770301631 19 dbSNP
rs748201654 24 dbSNP
rs780585303 26 dbSNP
rs550196940 27 dbSNP
rs1255643287 29 dbSNP
rs753869314 30 dbSNP
rs1419734999 32 dbSNP
rs1157893613 34 dbSNP
rs1052625836 40 dbSNP
rs866237901 42 dbSNP
rs192813571 47 dbSNP
rs1409991763 51 dbSNP
rs79838694 52 dbSNP
rs1055024350 57 dbSNP
rs1487122314 60 dbSNP
rs1243092014 64 dbSNP
rs896403523 66 dbSNP
rs1345725572 67 dbSNP
rs949375659 68 dbSNP
rs1222409318 69 dbSNP
rs577702111 77 dbSNP
rs1294142609 93 dbSNP
rs1246847162 94 dbSNP
rs1321149285 97 dbSNP
rs2013928 100 dbSNP
rs1383895588 106 dbSNP
rs1322103120 108 dbSNP
rs553979487 111 dbSNP
rs899792161 121 dbSNP
rs573551504 126 dbSNP
rs902549416 133 dbSNP
rs1397845594 134 dbSNP
rs1367054332 152 dbSNP
rs111592009 165 dbSNP
rs562509832 166 dbSNP
rs1203735921 177 dbSNP
rs779024957 183 dbSNP
rs1420777977 185 dbSNP
rs955330176 187 dbSNP
rs1490574042 199 dbSNP
rs1166196112 203 dbSNP
rs982561313 216 dbSNP
rs1487490988 229 dbSNP
rs996760763 231 dbSNP
rs1015411539 236 dbSNP
rs1271351616 236 dbSNP
rs112045007 237 dbSNP
rs955129930 238 dbSNP
rs1427307141 239 dbSNP
rs1308017384 241 dbSNP
rs386820652 241 dbSNP
rs973827802 242 dbSNP
rs113072258 243 dbSNP
rs1015202271 248 dbSNP
rs981550999 250 dbSNP
rs375674357 251 dbSNP
rs62235873 259 dbSNP
rs1461994894 269 dbSNP
rs758229865 272 dbSNP
rs961054414 276 dbSNP
rs973771772 278 dbSNP
rs185481808 284 dbSNP
rs1431955863 285 dbSNP
rs1200022664 293 dbSNP
rs1052698966 295 dbSNP
rs1265462940 298 dbSNP
rs1197633024 301 dbSNP
rs1480976899 303 dbSNP
rs777682631 322 dbSNP
rs937825270 323 dbSNP
rs1398787048 325 dbSNP
rs946875628 326 dbSNP
rs991065007 332 dbSNP
rs1283760052 356 dbSNP
rs917798814 357 dbSNP
rs189601650 361 dbSNP
rs1308648393 362 dbSNP
rs1300834816 369 dbSNP
rs1043783423 371 dbSNP
rs1398982122 372 dbSNP
rs1328652766 373 dbSNP
rs1465796456 373 dbSNP
rs35362381 373 dbSNP
rs398036845 373 dbSNP
rs747002903 374 dbSNP
rs78617859 375 dbSNP
rs896438499 389 dbSNP
rs1316816418 392 dbSNP
rs539636600 401 dbSNP
rs1294386719 409 dbSNP
rs949318938 412 dbSNP
rs1042356017 415 dbSNP
rs1360546013 417 dbSNP
rs996855013 437 dbSNP
rs1342555773 443 dbSNP
rs1029641364 447 dbSNP
rs902496699 451 dbSNP
rs734479 467 dbSNP
rs1177828431 472 dbSNP
rs1249780116 478 dbSNP
rs1417230097 486 dbSNP
rs1053839820 489 dbSNP
rs1004058131 490 dbSNP
rs181976412 491 dbSNP
rs372916972 497 dbSNP
rs962538087 502 dbSNP
rs1400576287 503 dbSNP
rs900590094 507 dbSNP
rs1423685219 508 dbSNP
rs996318438 510 dbSNP
rs1042249814 511 dbSNP
rs147307448 520 dbSNP
rs1379899514 521 dbSNP
rs1156941030 522 dbSNP
rs1446483545 523 dbSNP
rs1355902246 526 dbSNP
rs890660148 529 dbSNP
rs1238008635 534 dbSNP
rs1186815466 535 dbSNP
rs974322442 544 dbSNP
rs1442355728 547 dbSNP
rs1217050311 548 dbSNP
rs550515073 551 dbSNP
rs41282547 552 dbSNP
rs1247575280 559 dbSNP
rs1359471786 561 dbSNP
rs970232837 565 dbSNP
rs1373321608 573 dbSNP
rs1339220096 585 dbSNP
rs1390181628 589 dbSNP
rs1320753166 593 dbSNP
rs1317699513 594 dbSNP
rs1384028902 604 dbSNP
rs140985284 609 dbSNP
rs769468470 628 dbSNP
rs1309451669 638 dbSNP
rs1205389133 653 dbSNP
rs184434392 656 dbSNP
rs116368880 660 dbSNP
rs1471804432 660 dbSNP
rs762267983 661 dbSNP
rs1194124402 662 dbSNP
rs1487816174 668 dbSNP
rs988351449 672 dbSNP
rs1185348940 679 dbSNP
rs1288607031 680 dbSNP
rs1243631031 685 dbSNP
rs560127581 693 dbSNP
rs1181497051 695 dbSNP
rs1421296310 696 dbSNP
rs1340355297 697 dbSNP
rs1491289574 698 dbSNP
rs1491504707 699 dbSNP
rs1322988244 700 dbSNP
rs1403612510 700 dbSNP
rs946896523 700 dbSNP
rs555854953 701 dbSNP
rs576857410 702 dbSNP
rs370166878 703 dbSNP
rs1218744601 704 dbSNP
rs949271353 706 dbSNP
rs1470648806 720 dbSNP
rs1004172905 722 dbSNP
rs144944905 730 dbSNP
rs1317841462 734 dbSNP
rs1256626165 735 dbSNP
rs1221239059 746 dbSNP
rs3179442 749 dbSNP
rs1434428520 751 dbSNP
rs1337663268 758 dbSNP
rs995351551 763 dbSNP
rs1452419344 769 dbSNP
rs1398003696 778 dbSNP
rs1178333901 790 dbSNP
rs1313360349 795 dbSNP
rs1023246904 798 dbSNP
rs936619950 800 dbSNP
rs1189150509 801 dbSNP
rs1470944011 805 dbSNP
rs1238332520 806 dbSNP
rs1053788476 809 dbSNP
rs1177453978 810 dbSNP
rs376902647 811 dbSNP
rs1457722973 819 dbSNP
rs1256647401 822 dbSNP
rs757572007 827 dbSNP
rs1212722847 838 dbSNP
rs1313098354 843 dbSNP
rs1278331471 845 dbSNP
rs1217731918 848 dbSNP
rs1356116827 859 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccccaccCCUGUCUCCGAa 5'
                   ||  :|||| | 
Target 5' -----cuaaGGUGGGAGGAUc 3'
1 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000343605.4 | 3UTR | CUAAGGUGGGAGGAUCACUUGAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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