miRTarBase - #MIRT647145


—
pre-miRNA Information
pre-miRNA hsa-mir-4749   
Genomic Coordinates chr19: 49854591 - 49854651
Description Homo sapiens miR-4749 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4749-3p
Sequence 42| CGCCCCUCCUGCCCCCACAG |61
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN19730808 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs147943327 1 dbSNP
rs148982635 2 dbSNP
rs372882504 3 dbSNP
rs200056596 4 dbSNP
rs570340094 5 dbSNP
rs778438436 11 dbSNP
rs748573000 13 dbSNP
rs770230641 14 dbSNP
rs201103722 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CYP27C1   
Synonyms -
Description cytochrome P450 family 27 subfamily C member 1
Transcript NM_001001665   
Expression
Putative miRNA Targets on CYP27C1
3'UTR of CYP27C1
(miRNA target sites are highlighted)		 
>CYP27C1|NM_001001665|3'UTR
   1 GCCTAGATTTTAAACCTGGGCTGATGTAGCAGACCAGCTCGCCGACACACAGTGGGTATTTGTGTTCGCTGATCACCGTG
  81 GAGAAGGAAAGCGATGTCGCTAAAGGCTGTCTTGTTATAGACTGGCCTCCCAGGTCCTGGGACACTTGTAAATCTTTATG
 161 CAAAGTAATGTAAAAAGGTTGCTATTTTACTGGTGCATACCAGAAGTTGCCCTTTCTTTGGGGGAAACAGCTGTTTAAAA
 241 ACCAGTGGCAGTGAATTTTTATGCTTCATACATTGTGCTAGACTCAATATTTAATGACTGGCAGTATCCTGTGCATTTAC
 321 TTGTACAGGGAAATGGTGGTTTACTTACAAATTCAGTTCTTCAATATATGTTCTCTAATACTGGCATCTGGGCTCAAATT
 401 GCCATCAACAGTAAGTTGAAGGCAATTTCAACTTACTGTTTCTAATTTGAAGAGGGAACATTAAGAATGCCTCTGTAATA
 481 CTGTAATTATGGGAAGAAAGCACCAGAGGCAACATTTTATCCTGAGCACCAGATTTAGATCCTGTTAAAGGGCTCAAACT
 561 TAAAAGGGCTGGCCGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCAAGGTGGGAGGATTGCTTGAGC
 641 CAGAAGTTCGAGACCAGCCTGAGCAACATGGTGAAACCCTGTCTCTACCAAAAATACAAAAATTAGCCGGGCGTGGTGGT
 721 GCACACCTATGGTCCTAGTTACTCGGAAGACTGAGGCAGGAGGATCGTTTGAGCTCAGGAGGTTGGGTCTGCAGTGAGCT
 801 ATCTATGATGGCACCACTGCACTTCAGCCTGGGTGACAGAGTGAGACCCTTTCTCAAAAATAAAATAAAATAAAATAAAA
 881 TAAAATAAAATAAAATAAAATGGCTGTATAAGAATACTTTTCTCTCCACAACGAGTGCTTAATTTTCTAGTCATAATGCC
 961 TAATGAAGTTGACTATTAGTTTTTATTTGGAAGAAATAAATAATAAATAAATAATAAATAAATAAAAAAGAAAGCTCCTG
1041 GTGAAATCAAGAATAATCAGATTTTCTAACCAAATCTAAATACAGAGTAGAGCAGACGTATAAGAACTGGAAATATGATG
1121 ACGTAAAATTTTGTTGCCTAAGTTGTGAGAAGTAATAAAACAGGCAGCATGGAAAACAATGTAACTTTAGAACATTTTTA
1201 TTTCAAGGGAAAATAAATACATAAATAGAGATGCTACAGATACAACAATATTTTTATCTTGATGGTGTTGTTTTAAATAT
1281 CCACACAAGAACCCTCACCCAGTTGTGTGCCTGTGCCAGGCTCTCTGGGAAGCCGTGGCTCCGGGAGTGCTGGGTCCTGA
1361 GGAGTTCTGTTGCCTTTCCTGCTGCTCACCGGTTGCTAAGAGGAAACACCGTGATTTCCTGATGCTCTTGCCTTGTCATC
1441 ATGCCTGAAACAGCTTATTCCCAATTCTGTAATTCCTTTTACATAATCCTTCTCCAAAAATTACTTTCTTACTAATATAG
1521 ACCATACAGTTTTTTTTCCATTTAGTAAGTCACTCTGCAAAATAACCCTTAAGTAAATAGACATAATATCCATTTCACAT
1601 ACCATTTTTGTTAAAGTATATAATAAAGTTGAAATCTCTGTGTGGTAGCAGAATAACTCTAGTATGAATGCTGTAAATGT
1681 ACAGGTAAATGTGAAATTAGGTCATATTAACTGGCCAAGTGTTGGATTGATTACTTTGAGGTAGCAGTATACGTATATTA
1761 AGTTTTATAAACTAGATGAAATTGCATTCTGTTTGAGACTGAAATTTAAAAATATTGAGAATAACTAAGCGACTTGAAGT
1841 GACCTCTTATTCCCTGGGTATACATACAGTGTGACCCTCTCGTGAAGTGTGGCTCTGCCTGGGGATCAGCACAGGGTGAA
1921 TAGCAAAGTGCGGGCTGGGGGTAGCACCTGTGCCCGCTGCTGAGTCTCACTGAACAGGAAGGGAAGCAGCCAGACACGGG
2001 GGCCTCCTGGTGTGATGTAGCAGGAAGTGCAGGGCGCCACCCAGGAAGCATCCACGCCAAAGAAATGGAGATTCAGCTGG
2081 ACAAGTTTCTAGGTTCGCTACTGGTTTATAGGAAATATGTGGTATACAGGGAGATGTCAAAACTCCATGGGGGCTGGGCG
2161 TGGTGGCTCACACCTGTAATTTCAGCACTCTGGGGAGGTTGAGGCAGGAGGATTGCTTGAGGCCAGGAGTTTGAGACAAG
2241 CTTGGGCAACACAGTGAGATCCTGTCTACTAAAAATCAAAAAACTTAGCTGAGTGTGGTGGTGCATGCCTGTAGTCCTAG
2321 CTATTTGGGAGGCTGAGGCTGGAGGATTGCTTAAGTCTGGGAGGTTGAGGCTGCAGTGAGCTGTGATCCGCCATTACACT
2401 CCAGCCTGGGTGACAGAGCAAGACTTCATAACAAACAAACACACAAACAAACTCCATGGGGATGCAGTCAGCAAAATCCA
2481 GAATAGAGTGAGGTCTATAGGACCAATGTCTCGGGTTTCCAACAAAACAAATACGTGACAGGCAAAAAACAAGAGGAGGG
2561 GCCAGGCGAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGATAACCTGAGGTCAGGGGTTCC
2641 AGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAGAAATTATCCAGGCATGGTGGCGGGCTTCTGT
2721 AATTCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGTTTGCAGTGAGCTGAGATCACGCCA
2801 CTGCACTCCACCTGGGCAACAAGAACGAAACTCCGTATCTAAAAAAAACAAAAACCAAAAAGCAAAAAAAAAACCAAGGG
2881 GAGAGGAGAACTGTTACAGATGAAGCAATATAGGAGACATATTAACCAAGTACAATGCTGGACTTCGTTTGAATCAGATT
2961 CAAATAAACCACTTGTAAAAAGACATTTAAGAGATAATTTTTAAAAATAAAATAAAAGCCAAAAATATTAATTCTTCCAA
3041 TGCATGAAAAAAAGAGAGCAACTCGGGGAAATTTGAATGCTGACTGTGTGTATTTGATGATATTTGGGAATTACTGTTAA
3121 TTTTTTTGTTGTGATAATGGTAGTTATGTTTTAAAAAAAGAGACTTTATCTCTTGGAGATAGCTCTTAAAGATATAAATG
3201 TTTATGGCTGAAATGTTATGGCATCTTGGATTTGCTTTAAAATAACCCAGCTTGCTGCAGGAGGTGGGTATTGTGTGTGT
3281 GGGAAGGTGGGGAGGCTGCGGGAGGAAGAGATGACCCAAGATTAGGCAGATGTTGTTAACTGTGGAAGCAGGGTGGTGAG
3361 TGGGGGCTCATGACATTATGCTCTCTACTTTGTGTACGTGTGAACATTTCCGTAATAAAAGATGCCTTCAGAAAC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacacccccgUCCUCCCCGc 5'
                    ||||||||| 
Target 5' aaaaaacaagAGGAGGGGCc 3'
 2544 - 2563 150.00 -17.30
2 
miRNA  3' gaCACCCCCGUCCUCCCCgc 5'
            ||| ||| ||| ||||  
Target 5' gtGTGTGGGAAGGTGGGGag 3'
 3275 - 3294 122.00 -23.80
3 
miRNA  3' gaCACCCCCGUCCUCCccgc 5'
            || | |||||||||    
Target 5' agGTTGAGGCAGGAGGattg 3'
 2196 - 2215 114.00 -20.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30497322 3 COSMIC
COSN26972631 6 COSMIC
COSN30172095 6 COSMIC
COSN30189438 16 COSMIC
COSN31496033 31 COSMIC
COSN30493076 40 COSMIC
COSN507837 48 COSMIC
COSN30660686 50 COSMIC
COSN20097124 65 COSMIC
COSN31577946 77 COSMIC
COSN9079325 77 COSMIC
COSN31607433 93 COSMIC
COSN26972633 98 COSMIC
COSN26972632 99 COSMIC
COSN31792879 115 COSMIC
COSN30144892 123 COSMIC
COSN30190362 133 COSMIC
COSN30187139 178 COSMIC
COSN30144739 235 COSMIC
COSN9079324 268 COSMIC
COSN9858347 308 COSMIC
COSN20220012 393 COSMIC
COSN15002736 620 COSMIC
COSN7335909 649 COSMIC
COSN26234014 800 COSMIC
COSN16057554 836 COSMIC
COSN24569392 971 COSMIC
COSN25707327 1123 COSMIC
COSN6207855 1215 COSMIC
COSN27590695 1753 COSMIC
COSN9079323 1971 COSMIC
COSN18791983 1982 COSMIC
COSN30388597 2096 COSMIC
COSN6554110 2297 COSMIC
COSN24484246 2564 COSMIC
COSN17445418 2613 COSMIC
COSN32062986 2616 COSMIC
COSN21153763 2711 COSMIC
COSN16111032 2849 COSMIC
COSN31959788 2946 COSMIC
COSN24102605 3034 COSMIC
COSN1786336 3098 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs923605363 5 dbSNP
rs373462505 23 dbSNP
rs760777456 33 dbSNP
rs752865425 35 dbSNP
rs1213397240 37 dbSNP
rs369379268 40 dbSNP
rs774174574 41 dbSNP
rs762435442 43 dbSNP
rs1486759988 44 dbSNP
rs1265826741 49 dbSNP
rs765423286 53 dbSNP
rs1029189316 57 dbSNP
rs1169962889 58 dbSNP
rs1205209559 62 dbSNP
rs34169835 65 dbSNP
rs11384285 66 dbSNP
rs1473929618 67 dbSNP
rs1389210247 68 dbSNP
rs538776561 69 dbSNP
rs1013685437 74 dbSNP
rs1418081618 77 dbSNP
rs1472484852 83 dbSNP
rs946965805 92 dbSNP
rs1454704753 93 dbSNP
rs1302776764 95 dbSNP
rs1400232148 98 dbSNP
rs1186256856 101 dbSNP
rs566920819 109 dbSNP
rs922155363 110 dbSNP
rs1227568115 111 dbSNP
rs1257295183 117 dbSNP
rs1304513898 118 dbSNP
rs1318499595 120 dbSNP
rs1200168232 129 dbSNP
rs73953278 134 dbSNP
rs1484425529 144 dbSNP
rs533940325 149 dbSNP
rs1257809377 151 dbSNP
rs995912992 155 dbSNP
rs898785371 165 dbSNP
rs1213814803 168 dbSNP
rs1175858373 182 dbSNP
rs568257625 184 dbSNP
rs1410707784 188 dbSNP
rs966600723 198 dbSNP
rs548544468 216 dbSNP
rs1205991811 218 dbSNP
rs79738076 228 dbSNP
rs181582208 232 dbSNP
rs1248444577 237 dbSNP
rs1176038482 242 dbSNP
rs1341227332 242 dbSNP
rs571949981 246 dbSNP
rs1436696235 250 dbSNP
rs950790404 255 dbSNP
rs1395191970 259 dbSNP
rs189516784 266 dbSNP
rs1375319434 275 dbSNP
rs78516281 283 dbSNP
rs1300543681 290 dbSNP
rs539951552 293 dbSNP
rs1345581001 298 dbSNP
rs898434084 299 dbSNP
rs1429890867 308 dbSNP
rs1202076246 312 dbSNP
rs1234238487 313 dbSNP
rs530361663 319 dbSNP
rs1481189772 326 dbSNP
rs1023488710 327 dbSNP
rs1166399971 329 dbSNP
rs1251710064 331 dbSNP
rs1038731854 341 dbSNP
rs1012110607 348 dbSNP
rs185403914 366 dbSNP
rs143035628 368 dbSNP
rs978020354 374 dbSNP
rs1172858607 379 dbSNP
rs746789945 392 dbSNP
rs1462324810 393 dbSNP
rs868236536 408 dbSNP
rs1056255283 412 dbSNP
rs999690666 423 dbSNP
rs1304051499 431 dbSNP
rs1363891224 438 dbSNP
rs575503276 444 dbSNP
rs1274720305 449 dbSNP
rs1307671504 449 dbSNP
rs1221298555 455 dbSNP
rs1271736253 460 dbSNP
rs2134791 465 dbSNP
rs1470093675 469 dbSNP
rs773353258 493 dbSNP
rs2134792 506 dbSNP
rs1194854758 513 dbSNP
rs992364312 517 dbSNP
rs1474485494 524 dbSNP
rs1188306867 525 dbSNP
rs1420508656 527 dbSNP
rs1043430955 530 dbSNP
rs2134793 538 dbSNP
rs1321618071 548 dbSNP
rs370717680 557 dbSNP
rs377524129 568 dbSNP
rs772018591 574 dbSNP
rs995549846 579 dbSNP
rs192943074 580 dbSNP
rs1387771856 581 dbSNP
rs1272583126 588 dbSNP
rs571092008 590 dbSNP
rs867369350 591 dbSNP
rs187249526 612 dbSNP
rs1291030004 617 dbSNP
rs1243845938 620 dbSNP
rs778438991 623 dbSNP
rs1290202215 626 dbSNP
rs920654108 628 dbSNP
rs973398760 632 dbSNP
rs970018374 633 dbSNP
rs536339370 634 dbSNP
rs1051309454 637 dbSNP
rs1023585738 649 dbSNP
rs1012574639 650 dbSNP
rs960623973 652 dbSNP
rs1186141104 654 dbSNP
rs779559759 655 dbSNP
rs1476085593 664 dbSNP
rs768226083 665 dbSNP
rs1407184512 668 dbSNP
rs1039174366 671 dbSNP
rs1345317662 672 dbSNP
rs1413593511 678 dbSNP
rs936380897 680 dbSNP
rs902288268 681 dbSNP
rs924952741 685 dbSNP
rs1391039778 702 dbSNP
rs1162245314 705 dbSNP
rs1288043430 706 dbSNP
rs1456752955 708 dbSNP
rs1226036938 710 dbSNP
rs1414653804 711 dbSNP
rs1160283094 712 dbSNP
rs139776183 713 dbSNP
rs1010611790 715 dbSNP
rs111701538 720 dbSNP
rs1259906612 721 dbSNP
rs1486089871 728 dbSNP
rs917826046 731 dbSNP
rs538155833 732 dbSNP
rs992041854 741 dbSNP
rs959454760 743 dbSNP
rs944958885 744 dbSNP
rs1452222285 745 dbSNP
rs912115644 746 dbSNP
rs974147540 750 dbSNP
rs781547528 763 dbSNP
rs929455573 764 dbSNP
rs1327752652 766 dbSNP
rs184732499 767 dbSNP
rs1208274742 769 dbSNP
rs973449686 777 dbSNP
rs1280678975 780 dbSNP
rs970071205 783 dbSNP
rs1269788571 788 dbSNP
rs1232204234 792 dbSNP
rs982743839 797 dbSNP
rs757673856 805 dbSNP
rs955656240 807 dbSNP
rs1030315030 808 dbSNP
rs192298621 811 dbSNP
rs113841255 812 dbSNP
rs141498373 820 dbSNP
rs1000623902 821 dbSNP
rs1034926715 832 dbSNP
rs999390349 833 dbSNP
rs561270514 834 dbSNP
rs1042117334 836 dbSNP
rs386650209 836 dbSNP
rs556617659 836 dbSNP
rs1412023711 842 dbSNP
rs546712653 847 dbSNP
rs1370918370 854 dbSNP
rs1439429382 861 dbSNP
rs369627880 861 dbSNP
rs1321675090 864 dbSNP
rs945018684 869 dbSNP
rs1457011519 871 dbSNP
rs896433763 876 dbSNP
rs1249853784 881 dbSNP
rs1341664715 887 dbSNP
rs1197341330 892 dbSNP
rs1273529618 894 dbSNP
rs1056766653 895 dbSNP
rs764845064 897 dbSNP
rs1410452090 898 dbSNP
rs1174808842 899 dbSNP
rs1478431045 900 dbSNP
rs1377136281 901 dbSNP
rs1191785027 902 dbSNP
rs1371001284 902 dbSNP
rs1432325852 902 dbSNP
rs1454358783 902 dbSNP
rs373050096 902 dbSNP
rs377036396 902 dbSNP
rs71393842 902 dbSNP
rs966528602 902 dbSNP
rs937920036 903 dbSNP
rs1196764670 910 dbSNP
rs115264745 927 dbSNP
rs1010665587 932 dbSNP
rs908623457 933 dbSNP
rs1231183619 960 dbSNP
rs778701523 968 dbSNP
rs114812343 969 dbSNP
rs1320594665 975 dbSNP
rs1204046630 976 dbSNP
rs955537855 989 dbSNP
rs1448212813 991 dbSNP
rs1193502644 992 dbSNP
rs1416658098 993 dbSNP
rs199523426 1026 dbSNP
rs1167472987 1029 dbSNP
rs1345552827 1030 dbSNP
rs1453758968 1035 dbSNP
rs1008538079 1037 dbSNP
rs1387295870 1055 dbSNP
rs1273751403 1060 dbSNP
rs964293089 1083 dbSNP
rs1353743567 1089 dbSNP
rs890724661 1097 dbSNP
rs1047962429 1098 dbSNP
rs1322103312 1098 dbSNP
rs1033182033 1111 dbSNP
rs778288682 1116 dbSNP
rs903639419 1119 dbSNP
rs1020703986 1122 dbSNP
rs899337478 1123 dbSNP
rs567527240 1133 dbSNP
rs1009262482 1140 dbSNP
rs757126333 1156 dbSNP
rs1336794335 1158 dbSNP
rs896160844 1165 dbSNP
rs1415550474 1169 dbSNP
rs1402048273 1205 dbSNP
rs1037794292 1208 dbSNP
rs1173022630 1213 dbSNP
rs1373877523 1214 dbSNP
rs948819958 1223 dbSNP
rs758915892 1234 dbSNP
rs1313701098 1235 dbSNP
rs1379687016 1236 dbSNP
rs937935167 1237 dbSNP
rs1304810268 1240 dbSNP
rs1170915402 1243 dbSNP
rs1240242641 1246 dbSNP
rs993263316 1256 dbSNP
rs1279071296 1259 dbSNP
rs1345101834 1261 dbSNP
rs550726415 1265 dbSNP
rs1391060028 1267 dbSNP
rs371446110 1270 dbSNP
rs1188140640 1274 dbSNP
rs531117249 1278 dbSNP
rs905104526 1282 dbSNP
rs1253303775 1292 dbSNP
rs72843693 1293 dbSNP
rs1240136366 1305 dbSNP
rs1193558836 1306 dbSNP
rs28616640 1307 dbSNP
rs186818952 1334 dbSNP
rs1174544503 1335 dbSNP
rs866498150 1342 dbSNP
rs143480405 1343 dbSNP
rs1343654347 1345 dbSNP
rs1017335412 1350 dbSNP
rs1274981651 1353 dbSNP
rs1009006711 1354 dbSNP
rs1375251042 1365 dbSNP
rs1447496929 1383 dbSNP
rs1227204781 1389 dbSNP
rs890119759 1390 dbSNP
rs1026562355 1391 dbSNP
rs56400827 1396 dbSNP
rs1449147512 1401 dbSNP
rs993713088 1402 dbSNP
rs1301570176 1406 dbSNP
rs975398526 1408 dbSNP
rs1202872390 1411 dbSNP
rs1253522477 1419 dbSNP
rs1311559277 1427 dbSNP
rs1431754266 1431 dbSNP
rs543128794 1438 dbSNP
rs759692669 1442 dbSNP
rs1191780873 1446 dbSNP
rs1168265924 1451 dbSNP
rs1427026828 1460 dbSNP
rs899389786 1461 dbSNP
rs754173054 1463 dbSNP
rs574148302 1482 dbSNP
rs1465917221 1488 dbSNP
rs1037853370 1489 dbSNP
rs1325174402 1500 dbSNP
rs34621109 1508 dbSNP
rs1392140414 1511 dbSNP
rs1442481366 1512 dbSNP
rs1293537250 1516 dbSNP
rs1183414505 1519 dbSNP
rs867101640 1520 dbSNP
rs948871742 1523 dbSNP
rs1212505072 1529 dbSNP
rs369568115 1538 dbSNP
rs555714065 1538 dbSNP
rs926185603 1538 dbSNP
rs1472988039 1554 dbSNP
rs978954915 1563 dbSNP
rs373336166 1566 dbSNP
rs142764331 1567 dbSNP
rs1483789326 1573 dbSNP
rs1241655298 1574 dbSNP
rs766705071 1581 dbSNP
rs1251915053 1583 dbSNP
rs1188548036 1588 dbSNP
rs938721498 1590 dbSNP
rs1478039098 1591 dbSNP
rs924640922 1602 dbSNP
rs977388063 1608 dbSNP
rs760587242 1614 dbSNP
rs777832939 1625 dbSNP
rs1407080507 1634 dbSNP
rs3941396 1651 dbSNP
rs1324117567 1661 dbSNP
rs1291527896 1671 dbSNP
rs915135210 1679 dbSNP
rs1344143395 1683 dbSNP
rs1428007995 1684 dbSNP
rs989334755 1691 dbSNP
rs1290301973 1709 dbSNP
rs1035102220 1713 dbSNP
rs531791034 1719 dbSNP
rs1038230485 1721 dbSNP
rs910326784 1727 dbSNP
rs886955668 1734 dbSNP
rs1434114982 1739 dbSNP
rs1046846516 1743 dbSNP
rs934070641 1745 dbSNP
rs1264188223 1747 dbSNP
rs754995484 1749 dbSNP
rs773123615 1752 dbSNP
rs954572729 1753 dbSNP
rs1025943798 1754 dbSNP
rs1040143994 1767 dbSNP
rs1163815483 1768 dbSNP
rs1407114273 1773 dbSNP
rs1292040230 1776 dbSNP
rs942704166 1777 dbSNP
rs1310673769 1795 dbSNP
rs926216622 1795 dbSNP
rs979030134 1797 dbSNP
rs967596265 1799 dbSNP
rs1371737818 1815 dbSNP
rs993101409 1827 dbSNP
rs535991803 1829 dbSNP
rs963621728 1830 dbSNP
rs112927093 1831 dbSNP
rs1013537115 1837 dbSNP
rs77463432 1839 dbSNP
rs1440067616 1844 dbSNP
rs182535789 1867 dbSNP
rs1187944164 1869 dbSNP
rs960770909 1879 dbSNP
rs558855469 1881 dbSNP
rs1405800684 1882 dbSNP
rs1057474247 1884 dbSNP
rs1002299183 1895 dbSNP
rs751705541 1899 dbSNP
rs1016526535 1911 dbSNP
rs1403842352 1915 dbSNP
rs1415416720 1919 dbSNP
rs1005432189 1931 dbSNP
rs903242434 1932 dbSNP
rs1416893314 1935 dbSNP
rs1162448112 1937 dbSNP
rs36015311 1942 dbSNP
rs886986765 1945 dbSNP
rs556539267 1950 dbSNP
rs1370396638 1955 dbSNP
rs538437496 1956 dbSNP
rs1232133712 1958 dbSNP
rs1276856759 1959 dbSNP
rs1041756546 1965 dbSNP
rs1180865659 1966 dbSNP
rs1195434659 1973 dbSNP
rs1272093620 1981 dbSNP
rs947350229 1981 dbSNP
rs1200492374 1987 dbSNP
rs998022670 1992 dbSNP
rs915189461 1997 dbSNP
rs1248143511 1998 dbSNP
rs1191144906 2000 dbSNP
rs1221826331 2001 dbSNP
rs538544254 2002 dbSNP
rs566493638 2006 dbSNP
rs546248088 2012 dbSNP
rs1478190756 2016 dbSNP
rs1166949653 2017 dbSNP
rs1417878634 2018 dbSNP
rs1271659584 2020 dbSNP
rs1053693385 2035 dbSNP
rs191554862 2036 dbSNP
rs1438824306 2043 dbSNP
rs766476929 2051 dbSNP
rs910388104 2052 dbSNP
rs1288239299 2053 dbSNP
rs987676886 2054 dbSNP
rs566979984 2055 dbSNP
rs13413852 2056 dbSNP
rs1369804325 2062 dbSNP
rs1315869091 2063 dbSNP
rs1220186588 2071 dbSNP
rs531055703 2074 dbSNP
rs942755387 2081 dbSNP
rs1294409405 2096 dbSNP
rs1436033594 2097 dbSNP
rs1451654623 2098 dbSNP
rs565327024 2104 dbSNP
rs1392484474 2118 dbSNP
rs1239967150 2124 dbSNP
rs1479021787 2130 dbSNP
rs1043046934 2137 dbSNP
rs1460387079 2140 dbSNP
rs1165481866 2143 dbSNP
rs868292150 2145 dbSNP
rs868000084 2146 dbSNP
rs1391592028 2147 dbSNP
rs946284943 2148 dbSNP
rs768152067 2153 dbSNP
rs138636282 2159 dbSNP
rs532467573 2160 dbSNP
rs927427586 2180 dbSNP
rs1158258389 2195 dbSNP
rs1333872025 2203 dbSNP
rs1242579605 2204 dbSNP
rs1267112662 2229 dbSNP
rs959180810 2235 dbSNP
rs1203990291 2237 dbSNP
rs55912480 2245 dbSNP
rs1489031120 2252 dbSNP
rs1003427569 2259 dbSNP
rs1257313898 2264 dbSNP
rs543004670 2268 dbSNP
rs1474411442 2275 dbSNP
rs529412053 2277 dbSNP
rs1369500260 2279 dbSNP
rs903289539 2285 dbSNP
rs1453160045 2293 dbSNP
rs1156821732 2294 dbSNP
rs559819804 2295 dbSNP
rs1191198704 2297 dbSNP
rs542618279 2298 dbSNP
rs1250713970 2303 dbSNP
rs560422306 2305 dbSNP
rs779744779 2311 dbSNP
rs1025547262 2316 dbSNP
rs1340934877 2321 dbSNP
rs111245735 2325 dbSNP
rs563591031 2335 dbSNP
rs1355195594 2336 dbSNP
rs910431324 2337 dbSNP
rs866972582 2341 dbSNP
rs1216934200 2344 dbSNP
rs1018497692 2355 dbSNP
rs1214272604 2361 dbSNP
rs1482492684 2362 dbSNP
rs1051628568 2373 dbSNP
rs558454007 2384 dbSNP
rs545307413 2389 dbSNP
rs778150600 2390 dbSNP
rs1419071652 2393 dbSNP
rs971786178 2396 dbSNP
rs1255558409 2411 dbSNP
rs1180270738 2418 dbSNP
rs187887870 2424 dbSNP
rs1173283115 2441 dbSNP
rs1373818888 2442 dbSNP
rs908892484 2445 dbSNP
rs1304308371 2446 dbSNP
rs1402642926 2448 dbSNP
rs991535797 2451 dbSNP
rs748109585 2453 dbSNP
rs34191409 2456 dbSNP
rs1300056189 2457 dbSNP
rs1437069496 2462 dbSNP
rs1389082026 2464 dbSNP
rs1288281904 2477 dbSNP
rs1378509815 2483 dbSNP
rs183139968 2484 dbSNP
rs753178946 2485 dbSNP
rs145804404 2486 dbSNP
rs1211792922 2493 dbSNP
rs755177591 2493 dbSNP
rs1480498457 2497 dbSNP
rs1197349242 2498 dbSNP
rs981659881 2501 dbSNP
rs35887875 2513 dbSNP
rs56096327 2515 dbSNP
rs1392938480 2524 dbSNP
rs766756238 2528 dbSNP
rs1378045020 2531 dbSNP
rs760934777 2534 dbSNP
rs1450555764 2535 dbSNP
rs1402290265 2543 dbSNP
rs893191328 2544 dbSNP
rs1324702800 2550 dbSNP
rs1364871723 2553 dbSNP
rs983781302 2560 dbSNP
rs750278643 2562 dbSNP
rs1018288217 2567 dbSNP
rs1217138462 2568 dbSNP
rs1260553293 2570 dbSNP
rs1319138804 2573 dbSNP
rs1007279342 2574 dbSNP
rs767278824 2576 dbSNP
rs951033936 2577 dbSNP
rs889067895 2579 dbSNP
rs1261254322 2582 dbSNP
rs1257058700 2591 dbSNP
rs1052108828 2600 dbSNP
rs1209555265 2602 dbSNP
rs1168201955 2608 dbSNP
rs761672580 2612 dbSNP
rs1277106790 2613 dbSNP
rs35903447 2616 dbSNP
rs554465842 2617 dbSNP
rs768471239 2621 dbSNP
rs1360754432 2626 dbSNP
rs760081107 2628 dbSNP
rs1280551649 2635 dbSNP
rs1380260302 2638 dbSNP
rs991191925 2644 dbSNP
rs1233250254 2653 dbSNP
rs1288296076 2661 dbSNP
rs571839378 2667 dbSNP
rs1222315912 2669 dbSNP
rs928935201 2672 dbSNP
rs982096965 2673 dbSNP
rs190677424 2676 dbSNP
rs1373094184 2687 dbSNP
rs1020471820 2688 dbSNP
rs762485862 2695 dbSNP
rs990287789 2696 dbSNP
rs774954234 2701 dbSNP
rs957460092 2710 dbSNP
rs528791633 2711 dbSNP
rs7371196 2716 dbSNP
rs1168817262 2718 dbSNP
rs1425891710 2719 dbSNP
rs891119382 2733 dbSNP
rs1029625746 2741 dbSNP
rs1187846521 2745 dbSNP
rs549696985 2749 dbSNP
rs997398348 2751 dbSNP
rs1484769922 2753 dbSNP
rs1254071508 2762 dbSNP
rs1282950519 2764 dbSNP
rs897719579 2765 dbSNP
rs745481636 2767 dbSNP
rs1036173404 2768 dbSNP
rs1306470284 2779 dbSNP
rs1351560562 2780 dbSNP
rs941852514 2783 dbSNP
rs887561183 2795 dbSNP
rs529348512 2796 dbSNP
rs113016732 2797 dbSNP
rs1209082251 2805 dbSNP
rs1235675238 2823 dbSNP
rs113839876 2825 dbSNP
rs1045389464 2826 dbSNP
rs533244118 2827 dbSNP
rs749938345 2832 dbSNP
rs1437249637 2834 dbSNP
rs909660196 2835 dbSNP
rs1360699356 2836 dbSNP
rs565101966 2838 dbSNP
rs1414100107 2845 dbSNP
rs913462565 2848 dbSNP
rs1449455555 2849 dbSNP
rs990339981 2849 dbSNP
rs1374795337 2850 dbSNP
rs1309343209 2855 dbSNP
rs1409862770 2856 dbSNP
rs957763720 2857 dbSNP
rs1395374593 2862 dbSNP
rs879544843 2863 dbSNP
rs1276322777 2864 dbSNP
rs1048150209 2866 dbSNP
rs1459820574 2870 dbSNP
rs1210784017 2871 dbSNP
rs1456075639 2874 dbSNP
rs569029835 2874 dbSNP
rs929699342 2874 dbSNP
rs546652857 2876 dbSNP
rs911349528 2876 dbSNP
rs1170414214 2878 dbSNP
rs985951905 2879 dbSNP
rs1415353385 2880 dbSNP
rs955452546 2902 dbSNP
rs544832920 2903 dbSNP
rs1398655189 2905 dbSNP
rs1449105914 2913 dbSNP
rs1030091125 2915 dbSNP
rs62160251 2922 dbSNP
rs1183021996 2926 dbSNP
rs1276802894 2937 dbSNP
rs1346884648 2940 dbSNP
rs1223830114 2944 dbSNP
rs1437295629 2946 dbSNP
rs1257366556 2947 dbSNP
rs1248759394 2955 dbSNP
rs961961435 2956 dbSNP
rs1211858880 2957 dbSNP
rs1316056282 2969 dbSNP
rs985313223 2971 dbSNP
rs1238299596 2993 dbSNP
rs1450517463 2997 dbSNP
rs968556730 3002 dbSNP
rs1248054063 3003 dbSNP
rs1021437389 3016 dbSNP
rs1488893606 3018 dbSNP
rs1421916937 3040 dbSNP
rs1010331404 3042 dbSNP
rs4662573 3049 dbSNP
rs111695757 3056 dbSNP
rs368725134 3056 dbSNP
rs1403625560 3062 dbSNP
rs1006042223 3064 dbSNP
rs1290105813 3065 dbSNP
rs1239195554 3070 dbSNP
rs906142550 3074 dbSNP
rs887602885 3075 dbSNP
rs1338114247 3086 dbSNP
rs1220451634 3092 dbSNP
rs1251768908 3115 dbSNP
rs1334645575 3117 dbSNP
rs1207485049 3128 dbSNP
rs1291596386 3131 dbSNP
rs1451879289 3147 dbSNP
rs199594331 3148 dbSNP
rs1055591442 3155 dbSNP
rs1261526583 3158 dbSNP
rs1478993090 3160 dbSNP
rs1195057095 3164 dbSNP
rs1491471815 3167 dbSNP
rs1491418173 3168 dbSNP
rs1456471652 3169 dbSNP
rs1325672370 3172 dbSNP
rs1391544127 3191 dbSNP
rs369829198 3198 dbSNP
rs185910640 3205 dbSNP
rs1358416985 3206 dbSNP
rs1006406932 3207 dbSNP
rs906922176 3208 dbSNP
rs374821002 3218 dbSNP
rs1339745057 3224 dbSNP
rs566322790 3240 dbSNP
rs1362143902 3246 dbSNP
rs945676285 3247 dbSNP
rs1359497775 3248 dbSNP
rs913520085 3250 dbSNP
rs1215504380 3254 dbSNP
rs1434005486 3264 dbSNP
rs1054710446 3267 dbSNP
rs1283374453 3268 dbSNP
rs1489491190 3276 dbSNP
rs1206033386 3280 dbSNP
rs1255893699 3282 dbSNP
rs150376825 3289 dbSNP
rs182082027 3297 dbSNP
rs1369177796 3299 dbSNP
rs985619533 3300 dbSNP
rs1157115544 3316 dbSNP
rs955663327 3317 dbSNP
rs1421301840 3318 dbSNP
rs1289289629 3326 dbSNP
rs922672289 3327 dbSNP
rs140253994 3331 dbSNP
rs866539147 3332 dbSNP
rs1349781846 3338 dbSNP
rs1277275745 3353 dbSNP
rs1336063008 3355 dbSNP
rs1382911916 3356 dbSNP
rs1234716567 3358 dbSNP
rs1306630648 3365 dbSNP
rs1355486723 3370 dbSNP
rs961349884 3378 dbSNP
rs1371315525 3379 dbSNP
rs1239317647 3387 dbSNP
rs777546112 3397 dbSNP
rs1302196405 3398 dbSNP
rs943690788 3411 dbSNP
rs1006096127 3412 dbSNP
rs1321565544 3413 dbSNP
rs951961731 3417 dbSNP
rs1400655187 3418 dbSNP
rs1383378451 3440 dbSNP
rs151199189 3440 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacacccccgUCCUCCCCGc 5'
                    ||||||||| 
Target 5' -----acaagAGGAGGGGCc 3'
 		1 - 15
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000335247.7 | 3UTR | ACAAGAGGAGGGGCCAGGCGAGGUGGCUCAUGCCUGUAAUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-4749-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082256 MED29 mediator complex subunit 29 2 4
MIRT112161 OTUD3 OTU deubiquitinase 3 2 2
MIRT150036 MIDN midnolin 2 2
MIRT246308 HIST2H2AA3 histone cluster 2 H2A family member a3 2 4
MIRT246320 HIST2H2AA4 histone cluster 2 H2A family member a4 2 4
MIRT248254 SP1 Sp1 transcription factor 2 2
MIRT257944 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT466973 STARD7 StAR related lipid transfer domain containing 7 2 4
MIRT492322 SETD1B SET domain containing 1B 2 2
MIRT496204 EFCAB1 EF-hand calcium binding domain 1 2 2
MIRT497568 CCR6 C-C motif chemokine receptor 6 2 2
MIRT502990 CCDC71L coiled-coil domain containing 71 like 2 8
MIRT508300 SIX5 SIX homeobox 5 2 4
MIRT522472 ZAK mitogen-activated protein kinase kinase kinase 20 2 2
MIRT525825 VIMP selenoprotein S 2 4
MIRT528154 BCL2L1 BCL2 like 1 2 2
MIRT532606 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT551302 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT568777 FAM53C family with sequence similarity 53 member C 2 6
MIRT570896 METTL21A methyltransferase like 21A 2 2
MIRT570963 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT571167 ZNF85 zinc finger protein 85 2 2
MIRT576751 Tmem127 transmembrane protein 127 2 2
MIRT609854 DAZAP2 DAZ associated protein 2 2 2
MIRT627101 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT637060 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT639423 PKP1 plakophilin 1 2 2
MIRT643208 TYW3 tRNA-yW synthesizing protein 3 homolog 2 4
MIRT646251 PRSS38 protease, serine 38 2 2
MIRT647145 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT647429 ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2 2
MIRT650666 GAPDHP44 glyceraldehyde 3 phosphate dehydrogenase pseudogene 44 2 2
MIRT651816 USP49 ubiquitin specific peptidase 49 2 2
MIRT657376 HMGA1 high mobility group AT-hook 1 2 2
MIRT658105 FOXK1 forkhead box K1 2 2
MIRT658161 FCHSD1 FCH and double SH3 domains 1 2 2
MIRT662754 LRRC3C leucine rich repeat containing 3C 2 2
MIRT667209 NIPAL1 NIPA like domain containing 1 2 2
MIRT687003 RPL35 ribosomal protein L35 2 2
MIRT707057 NACC2 NACC family member 2 2 2
MIRT709048 MRO maestro 2 2
MIRT709054 MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2 2
MIRT709446 VWA2 von Willebrand factor A domain containing 2 2 2
MIRT709847 SNX12 sorting nexin 12 2 2
MIRT710790 IFNLR1 interferon lambda receptor 1 2 2
MIRT711696 GMPR guanosine monophosphate reductase 2 2
MIRT712462 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT713884 MOB3A MOB kinase activator 3A 2 2
MIRT715329 NTN1 netrin 1 2 2
MIRT715927 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT716533 ATF5 activating transcription factor 5 2 2
MIRT716937 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT717007 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT719139 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT720853 MEF2D myocyte enhancer factor 2D 2 2
MIRT721484 LTB4R2 leukotriene B4 receptor 2 2 2
MIRT721517 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722895 LRRC20 leucine rich repeat containing 20 2 2
MIRT723066 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723086 INSIG1 insulin induced gene 1 2 2
MIRT723353 ASCL2 achaete-scute family bHLH transcription factor 2 2 2
MIRT723483 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT724576 NOTCH2 notch 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4749 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4749-3p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4749-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)

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