pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol C8orf33   
Synonyms -
Description chromosome 8 open reading frame 33
Transcript NM_023080   
Expression
Putative miRNA Targets on C8orf33
3'UTR of C8orf33
(miRNA target sites are highlighted)
>C8orf33|NM_023080|3'UTR
   1 CGTCTCCCCGAACCTGAAACAATCCCCCTCCCTTGGGGTGGTGTAGGGGTTTGTTTTGAGTGCAGAGCCTTTCCAGGACT
  81 TCTGTTGTCAGAGAACCCTGGAGTTGGTCTGTCCCTGGCTGGTCCAAGGATTTGTAGCTGTTGTGAAGGTGTGAGACCAT
 161 CAGATAGGCAAAAGACCCCGTTCGTTTTCTGATGAAATGTTCTCTCTTTCAGAAGAGAGAGAGAGGTGCATTTAGAAAAT
 241 ATGCAATAAATTGAAGTGAGTGTTCAAAGTATTGTAGAAGGAATATTGTACTCAGTCTTTAGGATTAGATTAAGTGGCTG
 321 TTGGTAACAAAGATTAGTGGAGAAGCTGTATAATCGTACACTGGTTTTCACTTTTGAAAGGAATCCCTGTCAAATGGTTT
 401 AGTGCTTAATGCTGTTATGTCATATTGCCCTAATCTCTATTTTTGATAAAATTGGATAAGGAGTGAAAGAGTATGCTGAC
 481 CACCTATGTTAGAGGAAGTACAGAAGATGCAGGGGTGTGGTATCCCTGGGTCCAGTCCCTCACCTGGTACCTTTGTGCAT
 561 GTTGCCTTCATTCCTGAGCAGGTATCATCCTCAGGGAACCAGCATGGCACCTACCAGGCCAGGCTCTGTTCTTAGGAGCA
 641 AGGAGCTTCTTGCGCTAACAGTTCTGGCCTGAGACCTGGATTGAGCCTTGGCAGACTTCTTGTCTAAATGTTGGCCATTC
 721 AGTCTCAGGCCCTCTGTTCCATGGAATTGGGAATCTCCAGGTGACCTAATCCTCATTGGTGGCTTGATGTTTGCTGGTAT
 801 CTTCCAAACTCAGTTCCCAGACTAGATTGATACCTGGAGCCCAGCTGCCTACTCAGCATTTCCACTTGGGTGCTTCATAG
 881 GCATTTCAAACCTGATGTGTTTAAAACACTTGATTAGGCTCCGGTTTTCCTTTGGCTTCTGCTTTTCAGTGAATGGCATG
 961 ACTGCCTATGTGGGTGGCAAGCCACCCAGGTGCCGAGGAAAGAGACTGAGGGCACGAGCTGTTCCAGTATAATAAAATAT
1041 ATAAAATAAGAAGAGTTATACTAGATCTAGATCATAGACATGATTATATGTGAGTATCATTAATCATTAGTTTATAGCAA
1121 TTACTCTTTATTCCAATATTATAATAATCCTCACTCTACAATCATAACCTAGGAAAAACCAGGCCATACAGAGATAGGAG
1201 CCGAGGGGACATAGTGCGAAGTGGCCAGAAGACAAGAGTGTGAGCCTTCTCTTATGCCCGGACAGGGCCACCAGAGGGCT
1281 TGGTCTAGCAGTAACACCAGTGTCTGGGAAGATGCCTGTTGCAAAGTGGACCATGGTCTAGCAGTAGCATCAGTGTCAAG
1361 GAAAAACACCCACTACTTAGCAGACTGGGAAAAGGAGCCTCCCTTTCCCCGGGGGAGTTTAGAGAAGACTACTCCTCCAC
1441 CTCTTGTGGAGGGCCTGACATCAGTCAGGCCCGCCCGCAGTTATCCAGAGGCCTGTCTCCCTGTGATGCTGTGCTTCAGT
1521 GGTCACGCTCCTAGTCCGCTTTCATGTTCCATCCTGTATACCTGGCTCTGCCTTTTAGATAGCAGGAGCAAATTAGTGAA
1601 AGTACTAAATGTCTGATATGCAGAAATAATGGCATAAGCTGTCTCTCTCTCTTCTCTCTCTCTCTGCCTCTGCTGCCAGG
1681 CAGGGAAGGGCCCCCTGTCCAGTGGACACATGACCCATGTGACCTTACCTATTATTGGAGATGGTTCACATTCCTTACCC
1761 TGCCCCTTTGTCTTATATCCAATAAATATCAGTGCAGCCTGGCATTTGGGGCCACTACTGGTCTCCGCGTCTTGGTGGTA
1841 GTGGTCCCCCAGGCCCAGGTGTCTTTTCTTTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaUCGGAGGUA--CUUAAGACUAc 5'
            || | ||:|  |  ||||||| 
Target 5' aaAGACCCCGTTCGTTTTCTGATg 3'
171 - 194 154.00 -16.90
2
miRNA  3' gaUCGG--AGGUACUUAAGACUAc 5'
            ||||  |||| || ||||| | 
Target 5' agAGCCTTTCCAGGACTTCTGTTg 3'
64 - 87 142.00 -17.00
3
miRNA  3' gaUCGGAGGUACUUAAGACUAc 5'
            | :|||:||   ||:|||| 
Target 5' ctAATCTCTAT---TTTTGATa 3'
430 - 448 141.00 -11.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30462734 9 COSMIC
COSN26968804 11 COSMIC
COSN14331881 31 COSMIC
COSN30471195 32 COSMIC
COSN30182382 47 COSMIC
COSN30182469 48 COSMIC
COSN30503500 80 COSMIC
COSN30172018 83 COSMIC
COSN31479610 90 COSMIC
COSN18733376 99 COSMIC
COSN30484054 114 COSMIC
COSN30515710 131 COSMIC
COSN31554756 175 COSMIC
COSN216710 185 COSMIC
COSN2267290 263 COSMIC
COSN28317605 341 COSMIC
COSN17182077 428 COSMIC
COSN24375359 702 COSMIC
COSN9606511 1179 COSMIC
COSN20514572 1218 COSMIC
COSN9606512 1427 COSMIC
COSN8074508 1557 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs764830380 2 dbSNP
rs752466333 3 dbSNP
rs565670656 5 dbSNP
rs1306616677 7 dbSNP
rs373947092 10 dbSNP
rs549613898 11 dbSNP
rs781031731 16 dbSNP
rs750337382 19 dbSNP
rs755107273 21 dbSNP
rs902485461 23 dbSNP
rs201731914 25 dbSNP
rs748371034 26 dbSNP
rs199770781 29 dbSNP
rs375598944 30 dbSNP
rs1410946586 31 dbSNP
rs1182704551 32 dbSNP
rs747377871 39 dbSNP
rs771307072 42 dbSNP
rs1483920465 43 dbSNP
rs368448829 48 dbSNP
rs760117230 49 dbSNP
rs201384098 50 dbSNP
rs775411130 53 dbSNP
rs1280183552 58 dbSNP
rs1027818233 65 dbSNP
rs1221401859 66 dbSNP
rs776386116 68 dbSNP
rs965371384 74 dbSNP
rs976706271 78 dbSNP
rs556256432 79 dbSNP
rs1327776424 80 dbSNP
rs921212647 83 dbSNP
rs1229326497 84 dbSNP
rs760741150 85 dbSNP
rs1311242223 87 dbSNP
rs984408144 90 dbSNP
rs148456256 99 dbSNP
rs976826921 116 dbSNP
rs939822061 123 dbSNP
rs754004480 128 dbSNP
rs192295314 131 dbSNP
rs932421229 138 dbSNP
rs1049585239 141 dbSNP
rs1036802387 142 dbSNP
rs1415420248 144 dbSNP
rs915100536 150 dbSNP
rs1238693876 152 dbSNP
rs1479775027 152 dbSNP
rs1212969197 156 dbSNP
rs1175947787 162 dbSNP
rs762100431 164 dbSNP
rs916968967 166 dbSNP
rs1822 168 dbSNP
rs1463091712 174 dbSNP
rs1044077259 175 dbSNP
rs1311079543 179 dbSNP
rs905488237 180 dbSNP
rs1002464618 181 dbSNP
rs1369565127 182 dbSNP
rs572395414 184 dbSNP
rs373546946 186 dbSNP
rs76892209 193 dbSNP
rs1012311283 194 dbSNP
rs1391970422 198 dbSNP
rs1163889225 200 dbSNP
rs1027767506 202 dbSNP
rs1415431701 203 dbSNP
rs1184441036 205 dbSNP
rs1248161421 214 dbSNP
rs1448302378 214 dbSNP
rs753473380 214 dbSNP
rs764183059 214 dbSNP
rs1010129499 216 dbSNP
rs1264036313 222 dbSNP
rs1309130824 232 dbSNP
rs1221222219 233 dbSNP
rs1322701805 244 dbSNP
rs1021065056 246 dbSNP
rs1226490816 251 dbSNP
rs576324263 255 dbSNP
rs998177670 256 dbSNP
rs966703424 257 dbSNP
rs559299800 258 dbSNP
rs1365471696 265 dbSNP
rs759952052 266 dbSNP
rs150598133 269 dbSNP
rs755569949 270 dbSNP
rs780545495 279 dbSNP
rs1351430999 284 dbSNP
rs1271560414 286 dbSNP
rs1489952558 288 dbSNP
rs565055888 289 dbSNP
rs984070406 292 dbSNP
rs1390249923 295 dbSNP
rs1170005260 300 dbSNP
rs1452046747 300 dbSNP
rs909767820 304 dbSNP
rs1191153126 310 dbSNP
rs1488982589 322 dbSNP
rs1190927938 328 dbSNP
rs1248866042 329 dbSNP
rs1420868979 334 dbSNP
rs184452217 337 dbSNP
rs139451541 340 dbSNP
rs868813561 356 dbSNP
rs528509574 357 dbSNP
rs529647426 359 dbSNP
rs1300447810 361 dbSNP
rs1387333724 362 dbSNP
rs1369426910 384 dbSNP
rs972966305 388 dbSNP
rs1167788855 394 dbSNP
rs985234669 398 dbSNP
rs1370729882 402 dbSNP
rs917037064 404 dbSNP
rs915013656 405 dbSNP
rs1165055582 406 dbSNP
rs946494121 412 dbSNP
rs1435523350 413 dbSNP
rs1434289880 419 dbSNP
rs768000881 420 dbSNP
rs1289169479 425 dbSNP
rs949783724 426 dbSNP
rs1044133018 430 dbSNP
rs549434897 431 dbSNP
rs1482306413 436 dbSNP
rs1380452268 438 dbSNP
rs1295568384 440 dbSNP
rs1233877201 449 dbSNP
rs368275797 452 dbSNP
rs1286395728 458 dbSNP
rs567586566 461 dbSNP
rs372443387 463 dbSNP
rs894034683 474 dbSNP
rs1009769467 475 dbSNP
rs1243052065 476 dbSNP
rs1165400167 478 dbSNP
rs1342922870 479 dbSNP
rs1302986857 485 dbSNP
rs1487172987 488 dbSNP
rs1408862091 495 dbSNP
rs373408975 501 dbSNP
rs1157633881 502 dbSNP
rs531868871 503 dbSNP
rs1012216699 507 dbSNP
rs901313189 514 dbSNP
rs1184580679 518 dbSNP
rs1049110131 532 dbSNP
rs887863897 533 dbSNP
rs769398338 534 dbSNP
rs1201051729 542 dbSNP
rs1028337952 544 dbSNP
rs1005017066 551 dbSNP
rs149679143 552 dbSNP
rs1246927499 559 dbSNP
rs777424168 561 dbSNP
rs1208054863 570 dbSNP
rs374863271 571 dbSNP
rs1184849015 580 dbSNP
rs966315561 581 dbSNP
rs1383015352 584 dbSNP
rs1339563540 593 dbSNP
rs998198426 593 dbSNP
rs1397195580 603 dbSNP
rs1016880909 604 dbSNP
rs1362434646 606 dbSNP
rs1319107333 607 dbSNP
rs146210967 612 dbSNP
rs1457217407 617 dbSNP
rs1389838235 620 dbSNP
rs1029317696 621 dbSNP
rs953671831 625 dbSNP
rs1368049649 632 dbSNP
rs985129199 634 dbSNP
rs914962735 639 dbSNP
rs538796859 644 dbSNP
rs1465340163 646 dbSNP
rs977949073 647 dbSNP
rs961581956 654 dbSNP
rs540755640 655 dbSNP
rs753157653 660 dbSNP
rs1024152195 661 dbSNP
rs971191306 662 dbSNP
rs939270706 665 dbSNP
rs770636165 669 dbSNP
rs992456698 670 dbSNP
rs565942246 671 dbSNP
rs979866247 676 dbSNP
rs1296325792 688 dbSNP
rs1434996002 692 dbSNP
rs1366484680 700 dbSNP
rs1320858316 703 dbSNP
rs774268293 711 dbSNP
rs1385415143 714 dbSNP
rs1383385767 721 dbSNP
rs1390491284 724 dbSNP
rs1453492179 725 dbSNP
rs948016906 726 dbSNP
rs536619162 731 dbSNP
rs1388395471 733 dbSNP
rs554580324 748 dbSNP
rs887854093 750 dbSNP
rs576437072 754 dbSNP
rs935708414 756 dbSNP
rs188864498 758 dbSNP
rs1450800953 762 dbSNP
rs1227947828 767 dbSNP
rs1285457821 769 dbSNP
rs1267847331 770 dbSNP
rs559113090 772 dbSNP
rs577075141 773 dbSNP
rs945620137 777 dbSNP
rs1273484703 786 dbSNP
rs1228410879 788 dbSNP
rs1343720452 791 dbSNP
rs1042586968 798 dbSNP
rs1036511536 800 dbSNP
rs1231764849 828 dbSNP
rs1268072901 834 dbSNP
rs759375511 840 dbSNP
rs1184903765 845 dbSNP
rs1406975203 846 dbSNP
rs1368881458 849 dbSNP
rs540774451 850 dbSNP
rs1307658698 852 dbSNP
rs1430439677 855 dbSNP
rs1421806828 863 dbSNP
rs1170712299 866 dbSNP
rs1477698533 869 dbSNP
rs1377979803 874 dbSNP
rs902036202 879 dbSNP
rs559373211 884 dbSNP
rs1481953316 886 dbSNP
rs1250565463 888 dbSNP
rs1205457646 893 dbSNP
rs934139586 897 dbSNP
rs1275941144 903 dbSNP
rs1199241489 906 dbSNP
rs1344993545 908 dbSNP
rs997706346 909 dbSNP
rs377518402 912 dbSNP
rs139159026 918 dbSNP
rs144044865 919 dbSNP
rs1005585223 923 dbSNP
rs772091801 924 dbSNP
rs1402742863 926 dbSNP
rs7828404 929 dbSNP
rs994504662 934 dbSNP
rs1024204299 938 dbSNP
rs1182408293 940 dbSNP
rs971242018 954 dbSNP
rs1470996357 955 dbSNP
rs1235229009 961 dbSNP
rs1338850139 963 dbSNP
rs1442497310 967 dbSNP
rs1264254293 968 dbSNP
rs531928570 969 dbSNP
rs550051662 979 dbSNP
rs565146402 982 dbSNP
rs1229234768 989 dbSNP
rs528316398 995 dbSNP
rs1226954462 996 dbSNP
rs989874793 1008 dbSNP
rs1288043340 1014 dbSNP
rs181250224 1016 dbSNP
rs186116505 1017 dbSNP
rs764895850 1024 dbSNP
rs978333413 1028 dbSNP
rs1402246819 1041 dbSNP
rs1411089578 1045 dbSNP
rs1275952525 1048 dbSNP
rs984753048 1051 dbSNP
rs1244494831 1054 dbSNP
rs1185962206 1060 dbSNP
rs757534982 1062 dbSNP
rs766642786 1066 dbSNP
rs1204557908 1074 dbSNP
rs778675319 1083 dbSNP
rs1319138691 1090 dbSNP
rs1287932358 1092 dbSNP
rs370060837 1093 dbSNP
rs909238641 1094 dbSNP
rs559086563 1097 dbSNP
rs750166780 1099 dbSNP
rs1364299379 1107 dbSNP
rs1181271948 1108 dbSNP
rs1321142435 1111 dbSNP
rs548628069 1114 dbSNP
rs941444522 1115 dbSNP
rs1174145342 1117 dbSNP
rs1424330325 1118 dbSNP
rs1414003062 1119 dbSNP
rs1405665963 1121 dbSNP
rs1329554253 1125 dbSNP
rs1166115238 1126 dbSNP
rs901930922 1127 dbSNP
rs1425545821 1141 dbSNP
rs1408223832 1144 dbSNP
rs933452389 1153 dbSNP
rs1050619934 1154 dbSNP
rs188981347 1160 dbSNP
rs1346516450 1162 dbSNP
rs1490591058 1165 dbSNP
rs1294233490 1166 dbSNP
rs537354998 1169 dbSNP
rs897165625 1180 dbSNP
rs1226186902 1182 dbSNP
rs1011859456 1190 dbSNP
rs1296143218 1196 dbSNP
rs1021956263 1201 dbSNP
rs903489587 1202 dbSNP
rs544855537 1203 dbSNP
rs182472975 1204 dbSNP
rs907109377 1213 dbSNP
rs867529489 1214 dbSNP
rs1001406776 1218 dbSNP
rs373796396 1219 dbSNP
rs1274493681 1220 dbSNP
rs767951981 1221 dbSNP
rs62530105 1223 dbSNP
rs1480970747 1224 dbSNP
rs1269386296 1225 dbSNP
rs1203304735 1226 dbSNP
rs1482755361 1228 dbSNP
rs969257060 1230 dbSNP
rs1490789210 1234 dbSNP
rs1310311188 1236 dbSNP
rs984699178 1236 dbSNP
rs1196427036 1239 dbSNP
rs537363238 1240 dbSNP
rs1020011265 1242 dbSNP
rs879047270 1245 dbSNP
rs1286047119 1248 dbSNP
rs534783950 1252 dbSNP
rs1396588516 1256 dbSNP
rs1168630291 1257 dbSNP
rs6986329 1260 dbSNP
rs1428114407 1261 dbSNP
rs1176015237 1267 dbSNP
rs1168163106 1273 dbSNP
rs1480937941 1280 dbSNP
rs922891097 1291 dbSNP
rs955619685 1292 dbSNP
rs574504097 1297 dbSNP
rs1050567945 1299 dbSNP
rs1407171558 1299 dbSNP
rs1178961098 1302 dbSNP
rs541558605 1305 dbSNP
rs562984752 1308 dbSNP
rs1038884113 1309 dbSNP
rs574853775 1314 dbSNP
rs903439043 1315 dbSNP
rs999562724 1318 dbSNP
rs543708768 1324 dbSNP
rs929993321 1328 dbSNP
rs565209361 1329 dbSNP
rs187048970 1334 dbSNP
rs907161580 1335 dbSNP
rs969163197 1337 dbSNP
rs548002861 1340 dbSNP
rs559667132 1341 dbSNP
rs1016554712 1343 dbSNP
rs190819456 1344 dbSNP
rs1364564125 1347 dbSNP
rs1161587330 1348 dbSNP
rs972473414 1349 dbSNP
rs78900074 1350 dbSNP
rs570072018 1351 dbSNP
rs1020483739 1352 dbSNP
rs1226980998 1353 dbSNP
rs1292084108 1354 dbSNP
rs954764229 1355 dbSNP
rs182973440 1356 dbSNP
rs1316556519 1357 dbSNP
rs1207849475 1360 dbSNP
rs552518488 1363 dbSNP
rs561206100 1368 dbSNP
rs1195207408 1369 dbSNP
rs570759748 1372 dbSNP
rs370407607 1373 dbSNP
rs1381962090 1375 dbSNP
rs1043236886 1383 dbSNP
rs1160485444 1384 dbSNP
rs771862392 1387 dbSNP
rs748175613 1388 dbSNP
rs911458790 1394 dbSNP
rs963231607 1395 dbSNP
rs1388198762 1397 dbSNP
rs1161889506 1398 dbSNP
rs974259673 1399 dbSNP
rs896179915 1403 dbSNP
rs1013216834 1407 dbSNP
rs111963907 1411 dbSNP
rs1207692786 1411 dbSNP
rs930045651 1412 dbSNP
rs1045809359 1413 dbSNP
rs1227398983 1414 dbSNP
rs1363584541 1416 dbSNP
rs568154070 1417 dbSNP
rs1385469685 1421 dbSNP
rs1315061613 1423 dbSNP
rs937303013 1423 dbSNP
rs1426569859 1424 dbSNP
rs1384622522 1427 dbSNP
rs1056143803 1428 dbSNP
rs535247815 1429 dbSNP
rs1016139055 1431 dbSNP
rs1269094710 1431 dbSNP
rs138376981 1431 dbSNP
rs962253873 1432 dbSNP
rs772740437 1433 dbSNP
rs1351087865 1434 dbSNP
rs773487992 1435 dbSNP
rs1340609346 1441 dbSNP
rs1272438363 1442 dbSNP
rs1231471704 1443 dbSNP
rs954670376 1444 dbSNP
rs1266186895 1445 dbSNP
rs1348704279 1450 dbSNP
rs1464341985 1454 dbSNP
rs1328339166 1460 dbSNP
rs185847369 1460 dbSNP
rs1410615815 1462 dbSNP
rs763067228 1463 dbSNP
rs1469082234 1465 dbSNP
rs1017668635 1467 dbSNP
rs1471441156 1468 dbSNP
rs556591553 1469 dbSNP
rs1425831462 1470 dbSNP
rs574915093 1472 dbSNP
rs545357778 1473 dbSNP
rs557313802 1474 dbSNP
rs774541933 1477 dbSNP
rs1007212130 1478 dbSNP
rs190258438 1490 dbSNP
rs547983311 1491 dbSNP
rs182793590 1492 dbSNP
rs1336880879 1495 dbSNP
rs993064188 1496 dbSNP
rs917515481 1509 dbSNP
rs949015494 1515 dbSNP
rs1044717363 1521 dbSNP
rs547232376 1527 dbSNP
rs904950827 1528 dbSNP
rs962987809 1529 dbSNP
rs974689982 1532 dbSNP
rs1244304748 1533 dbSNP
rs1205894453 1534 dbSNP
rs34792719 1535 dbSNP
rs539344457 1538 dbSNP
rs776023859 1539 dbSNP
rs890386660 1541 dbSNP
rs552864468 1545 dbSNP
rs1282562784 1546 dbSNP
rs1245361063 1550 dbSNP
rs928688797 1557 dbSNP
rs571266891 1560 dbSNP
rs1432568632 1561 dbSNP
rs374074435 1564 dbSNP
rs1484296043 1567 dbSNP
rs991500347 1569 dbSNP
rs542366913 1570 dbSNP
rs563739769 1573 dbSNP
rs1162314427 1576 dbSNP
rs531013608 1584 dbSNP
rs978898425 1585 dbSNP
rs756680959 1593 dbSNP
rs151332640 1597 dbSNP
rs1485080498 1598 dbSNP
rs1241967163 1600 dbSNP
rs1041992057 1605 dbSNP
rs763580791 1610 dbSNP
rs187963399 1611 dbSNP
rs753390583 1612 dbSNP
rs113783495 1614 dbSNP
rs1051488327 1620 dbSNP
rs1317044621 1625 dbSNP
rs777722391 1626 dbSNP
rs778655761 1630 dbSNP
rs539518858 1635 dbSNP
rs1379835902 1636 dbSNP
rs1302181394 1642 dbSNP
rs949013742 1642 dbSNP
rs980388823 1642 dbSNP
rs1366942601 1646 dbSNP
rs1166013984 1648 dbSNP
rs1427320677 1650 dbSNP
rs1464123396 1650 dbSNP
rs1411964960 1652 dbSNP
rs536620522 1652 dbSNP
rs1222086131 1653 dbSNP
rs1490524663 1653 dbSNP
rs1491181489 1653 dbSNP
rs941707373 1653 dbSNP
rs546538357 1654 dbSNP
rs898791094 1656 dbSNP
rs1411273072 1661 dbSNP
rs1273631644 1662 dbSNP
rs192199919 1663 dbSNP
rs995783410 1664 dbSNP
rs1343433479 1667 dbSNP
rs1025875680 1671 dbSNP
rs535243500 1672 dbSNP
rs556651777 1674 dbSNP
rs761886200 1677 dbSNP
rs1405288718 1682 dbSNP
rs981597111 1693 dbSNP
rs1346833022 1694 dbSNP
rs1051632705 1696 dbSNP
rs1461051613 1697 dbSNP
rs1354428163 1700 dbSNP
rs557052686 1707 dbSNP
rs182781528 1710 dbSNP
rs958778484 1714 dbSNP
rs1427683673 1716 dbSNP
rs1007504219 1718 dbSNP
rs140443831 1719 dbSNP
rs1271332330 1725 dbSNP
rs904495404 1732 dbSNP
rs1480365763 1734 dbSNP
rs914587828 1736 dbSNP
rs1231171962 1738 dbSNP
rs111609333 1743 dbSNP
rs977384559 1746 dbSNP
rs1031714138 1747 dbSNP
rs1340396032 1748 dbSNP
rs1325166989 1751 dbSNP
rs924517588 1752 dbSNP
rs1390266092 1753 dbSNP
rs1373494623 1757 dbSNP
rs956325223 1758 dbSNP
rs1449733269 1759 dbSNP
rs933188513 1760 dbSNP
rs1176083590 1762 dbSNP
rs1470509568 1764 dbSNP
rs1014415678 1767 dbSNP
rs1024452808 1773 dbSNP
rs1134051 1776 dbSNP
rs888907299 1777 dbSNP
rs1482949960 1778 dbSNP
rs541716685 1780 dbSNP
rs910155642 1782 dbSNP
rs943139048 1787 dbSNP
rs1037824954 1793 dbSNP
rs746933037 1794 dbSNP
rs1270112020 1798 dbSNP
rs1431876337 1804 dbSNP
rs1462507220 1808 dbSNP
rs779756573 1815 dbSNP
rs963039651 1816 dbSNP
rs993554277 1819 dbSNP
rs1047375609 1820 dbSNP
rs751490233 1821 dbSNP
rs1308586576 1822 dbSNP
rs1166364728 1824 dbSNP
rs553365530 1826 dbSNP
rs1003083669 1827 dbSNP
rs1381135572 1828 dbSNP
rs575102602 1829 dbSNP
rs542478994 1830 dbSNP
rs1404862126 1831 dbSNP
rs1365489378 1832 dbSNP
rs929085363 1835 dbSNP
rs1051576686 1844 dbSNP
rs1160462082 1846 dbSNP
rs911755410 1848 dbSNP
rs188004940 1850 dbSNP
rs1013015869 1851 dbSNP
rs531075151 1853 dbSNP
rs546310968 1857 dbSNP
rs1386133743 1862 dbSNP
rs1022105592 1867 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000331434.6 | 3UTR | AUGAAAUGUUCUCUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000331434.6 | 3UTR | AUGAAAUGUUCUCUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.351 0.1 0.286 0.15 15 Click to see details
BRCA 0.162 0.19 0.208 0.13 31 Click to see details
BLCA 0.372 0.23 0.029 0.48 6 Click to see details
HNSC -0.159 0.29 -0.411 0.07 14 Click to see details
LIHC 0.399 0.3 0.400 0.3 4 Click to see details
UCEC -0.258 0.42 -0.500 0.33 3 Click to see details
STAD 0.086 0.47 -0.500 0.33 3 Click to see details
STAD 0.086 0.47 -0.500 0.33 3 Click to see details
STAD 0.086 0.47 -0.500 0.33 3 Click to see details
STAD 0.086 0.47 -0.500 0.33 3 Click to see details
STAD 0.086 0.47 -0.500 0.33 3 Click to see details
STAD 0.086 0.47 -0.500 0.33 3 Click to see details
STAD 0.086 0.47 -0.500 0.33 3 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

Error report submission