miRTarBase - #MIRT647379


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pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZDHHC23   
Synonyms DHHC-23, NIDD
Description zinc finger DHHC-type containing 23
Transcript NM_173570   
Expression
Putative miRNA Targets on ZDHHC23
3'UTR of ZDHHC23
(miRNA target sites are highlighted)		 
>ZDHHC23|NM_173570|3'UTR
   1 GCCAACTCCGCTTCCTTCCCATGGATAGGAAGGGACTCTGTGTATTATTCAGGTTTATTGGCACGAAGATACTTGTTTTA
  81 AGTTCCTTGAGAACCCATGATGGACAGTTGACAGAATGCTTAAACCTGTCAAAAGATGAGTGATCTTGTGTGGGAAAAGC
 161 CTTCCCAGGCGTCTGTACCGAAAGGAGCAGCAAACAAGGGGCTAATCCATGAGCAGTGTTCTGTAGGCTCTGTGACATCT
 241 TTGGTTTATAGGATTTTGGAGCCTTTTATGATCTGGAACTATTTGAGGGGTTTCATTATAGGCCTTGGTTCTCTCCAGGG
 321 GCCAGATGAGTTTATTGTGGAATCTTTGAAAGGACAAGGCCTCTGTGAATGAATCAGTCCCAGGGAAGCATTTGGTGGTG
 401 GCGGCAGTGGAGGATTGCCCGGTGAACCTATAAATCAGCAGTCTCTTGGGCAGAGGAGCAAGCCCCTCGAACATGATTTC
 481 AAACAAGCAGGTCCTCTTCTCTCATCTCACGTCCTTAGTCTCTGTTAATGAACATACTGGATGTGGAGTTTAATAAATTA
 561 CCTACTATCATCTGGCCACTTAGATTATTATCACACCACTGTGGACTGTTCCTGGGGGGAGAAGAACAGACCGATTTGAA
 641 AGATTCAAGGGAGAAAGATTAAGGATCAGGATTGCATGAAAGAAGAAAATCCTTCAATATTTAAAATGTTTCTTACAATA
 721 CCCACGGAGCACTTTTATGGTTCCAGCCGAGCGTTCCTGAAATGAACTGACCATTAACAGCGCCTCTTTGATAGGTTACC
 801 CTGATGCTGCTAAAGTAAAGCCTTAAGTGTGTTTTTGGGACAACGTGCTGCTTATTCCACCTCAGCCACATATGTGTTTG
 881 TGTTTAGGATATTGTAAATCTTTGCTAAGTAGTGTTTTCCTTGGTGAATGAAGTCATTGTTGTCTTCAAGTGTACCATCT
 961 GCCTAGCAAAAAATTGCTACAAACTTTCTCTTATGCAATAGTCCTTGGTACTTCTAATATTTTTAGCAAGAGACAATTTT
1041 CTGTACTAGAATCTTCCACTGCCAGAAAACACAGTGCCAGTAAGGTTCTACATACCACTGACCATCTGCTTAATAGACAT
1121 GTATTTCCTTTGAGTAGGACATTAGCTTTTGATTATAAAGCTCAACTAGTATAAGCAAAAATATAACATCTAGAAGCACA
1201 GTTTTAGCCAGGATGTTTAAAAATTACAGTTTTGTGAGACTTAAGGGTCTTTTTAACCTAGGTAAGTTTATATGACCTAA
1281 CTTAATTGTAGCCATATTCTGGTACCTTCCATTTTGAAAAGTAGAGGTTGCTTAAGCAAGCAATGGATAATAAGAGACTT
1361 TTCCTGAGGCACCTGTTTGGAATCTGGTTTTCTCAGCGGCAGCTTGACATGTGCACCCTTTTGTATTAAACACTGCAAGG
1441 GTGATGCAGGGGAGCAGGAAAGCCATCCTAAACTCACTACTGAGTACGATTCAGTATGTTCCTGTGGATGTCTGCTGTGA
1521 CTAATATAAATTTCTTGCAGAATCAGCTACACTTAATTATGTTGCTGATAGACAAGCATCCACGCTTCAGCTGGCACTAA
1601 GTGTTTTCATTGTAGGATCAGCAGCAGGTTAAAGACTGAACGGTTAGTGAAGACAAATGTCTTAAGAGGCTGCGATGTCT
1681 AGGTTGGGCTTGTGACTTCTTAGTGGCCTAGCCTTCTTGATGGCACCTTGAAAGTGAACTTCTAGAAATCTACATTTAAA
1761 AGGCAAAGCTTTAAAAGCAGAGCTAGTCTATTCTAGTTACTGATGCAACTAAAATTCTGTATTTCTTAAGATGGAGCCAC
1841 TGACGAGATGTCACAGTATAGAGCCTGCAGTCTCAACTCATTGTGATCCTAATGGTCTGGGTGATTGGATGGTTTGAGTT
1921 GTTAGGGATTTTGAGTTTTTCATTTTATTGCATATCTGGGTTGGATGTTAGACTAAAGGAAACCCAGGAATATTTACCTG
2001 GTGTTACATTTAATATTTAATGTAACTGGTCTAGCAACATTAAGGGGGATTTCTGAAGCCAACTCCGGAGGCTGTGGGCT
2081 GCACATTTTGCACTGTTTTTATATACTTGTATTCATATCCTCTTATCACCTCAGACTCAGACACAAGGCCTTTTACATGG
2161 AAATTTTACAAATTACTTCCATTTATGTAAAATAACGTCCTGTGACCAAGTTGTTTAAATGGAAAATAAAGTGCTTTCTT
2241 TAAGGAAAATAGCTGGTGTTTCTTGGAGTGTCTCCTGAAGTCTTCTGATTTCTGAAAACCCTGCATTATACCTGTGCTGC
2321 CTCTGTGGCTCCCTCAATGTCTCTATCCTGTGGCCCTGTCCCTAGCCCTAAACTGTTATGTTCCCGGTGGCAATTTCTCC
2401 AGTTTTGTGGGTCAGGGATACTGCTTGTTGGGGCATTATGTTAACAGTAACATTTTGAAACATACTTTCATGATAGTCCA
2481 GCAAAAAACAGCATCAAAACTATTTCCATTGTATCTCTTTAGAAGGCTCTGTATTCGGTAAAAAGTCTAGCTGGCGCCAT
2561 TGGAATATGGGCTGCTAAAGACTCAATTTCTAGTTGATGTTTGAGGTGAGGCAAAAATAAAGCTAAGGTAGAAAACTTAA
2641 AAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agAUUGUGGUG-UCACACCAAAc 5'
            ||| :|| : |||||| ||| 
Target 5' agTAAAGCCTTAAGTGTGTTTTt 3'
 814 - 836 136.00 -10.10
2 
miRNA  3' agAUUGUGGUGUCACACCAAAc 5'
            |:|||:|    | |||||| 
Target 5' tgTGACATC----TTTGGTTTa 3'
 231 - 248 126.00 -8.80
3 
miRNA  3' agAUUGUGGUGUCACACCAAAc 5'
            |::|||:| |  ||| ||| 
Target 5' gcTGGCACTA-A--GTGTTTTc 3'
 1590 - 1608 123.00 -13.83
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30494128 8 COSMIC
COSN28617749 10 COSMIC
COSN23767120 19 COSMIC
COSN30472960 33 COSMIC
COSN30525240 52 COSMIC
COSN30477992 66 COSMIC
COSN26641827 87 COSMIC
COSN30100417 149 COSMIC
COSN30539836 165 COSMIC
COSN30127402 180 COSMIC
COSN30502332 184 COSMIC
COSN1265484 249 COSMIC
COSN30170178 263 COSMIC
COSN31528643 643 COSMIC
COSN30540305 727 COSMIC
COSN26647329 882 COSMIC
COSN26552541 895 COSMIC
COSN31661060 1124 COSMIC
COSN28652548 1372 COSMIC
COSN28202115 1463 COSMIC
COSN25666324 1556 COSMIC
COSN32057209 1584 COSMIC
COSN9734257 1835 COSMIC
COSN1907534 1984 COSMIC
COSN16132475 2199 COSMIC
COSN4810202 2208 COSMIC
rs1386478 1372 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs984163047 2 dbSNP
rs1279439211 3 dbSNP
rs1342957287 5 dbSNP
rs909890125 5 dbSNP
rs1217143173 6 dbSNP
rs12629415 10 dbSNP
rs375347619 11 dbSNP
rs769642529 21 dbSNP
rs774541291 22 dbSNP
rs202235136 23 dbSNP
rs773191831 26 dbSNP
rs761191724 28 dbSNP
rs766806202 32 dbSNP
rs1398597778 33 dbSNP
rs1192128805 39 dbSNP
rs754161995 45 dbSNP
rs755392408 46 dbSNP
rs1206630210 51 dbSNP
rs1037261063 59 dbSNP
rs1383782587 61 dbSNP
rs1284748703 63 dbSNP
rs750274447 65 dbSNP
rs1470818187 73 dbSNP
rs1213292695 75 dbSNP
rs898685852 76 dbSNP
rs572540734 82 dbSNP
rs868286421 92 dbSNP
rs1461387717 93 dbSNP
rs1184829101 100 dbSNP
rs1478078299 104 dbSNP
rs541544850 106 dbSNP
rs995700401 109 dbSNP
rs1191111934 116 dbSNP
rs1044558346 118 dbSNP
rs542631671 119 dbSNP
rs1245544653 121 dbSNP
rs905975156 126 dbSNP
rs868245896 128 dbSNP
rs1002954785 131 dbSNP
rs1206018253 143 dbSNP
rs3732785 146 dbSNP
rs956003233 149 dbSNP
rs1320536381 150 dbSNP
rs1409226516 152 dbSNP
rs1428019485 156 dbSNP
rs1010121855 160 dbSNP
rs568930240 166 dbSNP
rs1388113242 167 dbSNP
rs968586622 171 dbSNP
rs975009455 172 dbSNP
rs921787036 176 dbSNP
rs180767048 180 dbSNP
rs573211499 181 dbSNP
rs1280058665 182 dbSNP
rs1369094227 182 dbSNP
rs987204614 184 dbSNP
rs1185684108 190 dbSNP
rs1460106240 192 dbSNP
rs1242929056 196 dbSNP
rs1352641515 209 dbSNP
rs148867136 210 dbSNP
rs766131381 228 dbSNP
rs907545823 245 dbSNP
rs1055985007 249 dbSNP
rs1212328841 250 dbSNP
rs1338215737 251 dbSNP
rs1315078714 255 dbSNP
rs1247733400 265 dbSNP
rs573365933 277 dbSNP
rs1323752710 286 dbSNP
rs1335910274 291 dbSNP
rs1447219548 300 dbSNP
rs1037354681 302 dbSNP
rs920205584 303 dbSNP
rs1014450233 310 dbSNP
rs931547764 313 dbSNP
rs540777389 329 dbSNP
rs1044996036 331 dbSNP
rs1026148384 336 dbSNP
rs1205040719 346 dbSNP
rs754611054 347 dbSNP
rs558660579 351 dbSNP
rs1003375252 355 dbSNP
rs1057186200 360 dbSNP
rs797013221 372 dbSNP
rs1179706668 376 dbSNP
rs1233955416 382 dbSNP
rs187667709 384 dbSNP
rs1471341543 391 dbSNP
rs964050327 393 dbSNP
rs1010216222 394 dbSNP
rs1231493139 399 dbSNP
rs1204465764 400 dbSNP
rs1021567491 403 dbSNP
rs904482533 404 dbSNP
rs1224056236 405 dbSNP
rs996070028 410 dbSNP
rs955381461 414 dbSNP
rs1223956076 416 dbSNP
rs1375292147 419 dbSNP
rs376489909 421 dbSNP
rs1331608752 422 dbSNP
rs1470399906 423 dbSNP
rs1422794076 427 dbSNP
rs778598900 431 dbSNP
rs1159502204 444 dbSNP
rs752225289 446 dbSNP
rs563220478 455 dbSNP
rs1478680662 465 dbSNP
rs1014708410 469 dbSNP
rs1404081629 470 dbSNP
rs142015789 477 dbSNP
rs926263334 487 dbSNP
rs867664060 488 dbSNP
rs1413961575 495 dbSNP
rs530189270 502 dbSNP
rs1318282058 503 dbSNP
rs759024321 505 dbSNP
rs191938190 509 dbSNP
rs9816344 511 dbSNP
rs980343721 512 dbSNP
rs927463716 518 dbSNP
rs1287431750 521 dbSNP
rs1344992925 528 dbSNP
rs866070078 531 dbSNP
rs1014831685 534 dbSNP
rs1433157667 537 dbSNP
rs1047186811 542 dbSNP
rs887289684 553 dbSNP
rs1415374185 560 dbSNP
rs528150458 579 dbSNP
rs146518194 582 dbSNP
rs551191879 582 dbSNP
rs1017057816 583 dbSNP
rs1057478929 588 dbSNP
rs1486677523 593 dbSNP
rs1239978943 597 dbSNP
rs561829704 598 dbSNP
rs1029986213 602 dbSNP
rs1264715727 604 dbSNP
rs1221624870 611 dbSNP
rs530939551 612 dbSNP
rs1195813806 614 dbSNP
rs1296467300 614 dbSNP
rs988466747 616 dbSNP
rs1274331041 618 dbSNP
rs1440023917 619 dbSNP
rs1202895161 620 dbSNP
rs1408776632 622 dbSNP
rs891909507 627 dbSNP
rs143613551 633 dbSNP
rs1374131435 649 dbSNP
rs967869764 657 dbSNP
rs979139353 659 dbSNP
rs1480963299 660 dbSNP
rs926400611 669 dbSNP
rs1461443831 678 dbSNP
rs1201530102 679 dbSNP
rs937677286 679 dbSNP
rs138080145 698 dbSNP
rs1251787783 700 dbSNP
rs1201934737 716 dbSNP
rs1427386585 717 dbSNP
rs917583787 719 dbSNP
rs1043042772 723 dbSNP
rs771208339 726 dbSNP
rs996510467 731 dbSNP
rs1028886637 733 dbSNP
rs532154765 739 dbSNP
rs1452349959 741 dbSNP
rs1168526815 747 dbSNP
rs890352614 749 dbSNP
rs1352269800 750 dbSNP
rs550553437 753 dbSNP
rs775290262 757 dbSNP
rs1181577014 762 dbSNP
rs1038460132 771 dbSNP
rs961831023 776 dbSNP
rs973108629 780 dbSNP
rs554953139 782 dbSNP
rs183711888 783 dbSNP
rs1250900213 788 dbSNP
rs1223310139 792 dbSNP
rs188197987 793 dbSNP
rs1029624081 797 dbSNP
rs1289819788 798 dbSNP
rs1330083810 799 dbSNP
rs980777675 800 dbSNP
rs536591373 803 dbSNP
rs938919232 804 dbSNP
rs1390172716 806 dbSNP
rs1373241261 807 dbSNP
rs563101248 811 dbSNP
rs1424715558 817 dbSNP
rs1366851498 824 dbSNP
rs913398948 828 dbSNP
rs1457045808 832 dbSNP
rs145882539 832 dbSNP
rs554802639 836 dbSNP
rs967837299 842 dbSNP
rs373074323 845 dbSNP
rs1225095930 846 dbSNP
rs1250963540 847 dbSNP
rs763004372 866 dbSNP
rs190342322 869 dbSNP
rs1289618292 870 dbSNP
rs1222036344 872 dbSNP
rs559029243 874 dbSNP
rs959083372 875 dbSNP
rs992333576 895 dbSNP
rs1237318244 901 dbSNP
rs1194141221 911 dbSNP
rs1374903504 912 dbSNP
rs1316891632 921 dbSNP
rs932027216 925 dbSNP
rs1050847380 926 dbSNP
rs142358327 933 dbSNP
rs1346866510 936 dbSNP
rs543996370 937 dbSNP
rs1167948508 939 dbSNP
rs908833256 950 dbSNP
rs1426325425 952 dbSNP
rs1160137835 954 dbSNP
rs1009229286 956 dbSNP
rs1451323079 974 dbSNP
rs1036198190 975 dbSNP
rs1389599140 977 dbSNP
rs1038513918 979 dbSNP
rs900003754 989 dbSNP
rs773137288 994 dbSNP
rs373776687 999 dbSNP
rs551863371 1000 dbSNP
rs1264096299 1001 dbSNP
rs1203796485 1015 dbSNP
rs1485759551 1019 dbSNP
rs1264081801 1020 dbSNP
rs556321619 1027 dbSNP
rs566975574 1037 dbSNP
rs759152321 1038 dbSNP
rs1280880523 1044 dbSNP
rs1001905768 1049 dbSNP
rs376162934 1055 dbSNP
rs145954519 1061 dbSNP
rs756726524 1064 dbSNP
rs542142800 1066 dbSNP
rs1380116181 1068 dbSNP
rs1387647441 1071 dbSNP
rs903815617 1072 dbSNP
rs1248653164 1074 dbSNP
rs560295515 1083 dbSNP
rs1264102510 1089 dbSNP
rs1356052387 1090 dbSNP
rs527894870 1091 dbSNP
rs1191323262 1093 dbSNP
rs1000748521 1094 dbSNP
rs1206013798 1098 dbSNP
rs1205955815 1103 dbSNP
rs1033436086 1105 dbSNP
rs959210144 1108 dbSNP
rs991906628 1111 dbSNP
rs1463612985 1119 dbSNP
rs960357493 1121 dbSNP
rs1315539123 1124 dbSNP
rs866415879 1126 dbSNP
rs1454355100 1129 dbSNP
rs1025167146 1131 dbSNP
rs1333463046 1135 dbSNP
rs752315252 1140 dbSNP
rs1243710067 1155 dbSNP
rs1166228829 1163 dbSNP
rs138518207 1164 dbSNP
rs1386073461 1168 dbSNP
rs908885434 1181 dbSNP
rs376579075 1188 dbSNP
rs1237217781 1189 dbSNP
rs1183176481 1193 dbSNP
rs531973721 1205 dbSNP
rs757979354 1210 dbSNP
rs1439991539 1214 dbSNP
rs1274581237 1216 dbSNP
rs1454105070 1226 dbSNP
rs974339594 1228 dbSNP
rs921404267 1230 dbSNP
rs932842203 1230 dbSNP
rs1376730303 1233 dbSNP
rs867661125 1248 dbSNP
rs1283316178 1250 dbSNP
rs1382234841 1257 dbSNP
rs978881604 1258 dbSNP
rs926090209 1261 dbSNP
rs1429154303 1262 dbSNP
rs932053690 1263 dbSNP
rs1413527931 1280 dbSNP
rs1384335486 1293 dbSNP
rs1051171064 1297 dbSNP
rs550542186 1306 dbSNP
rs1231646980 1313 dbSNP
rs945391233 1315 dbSNP
rs1042337035 1323 dbSNP
rs1268916293 1338 dbSNP
rs911844154 1344 dbSNP
rs1319548376 1345 dbSNP
rs1288954552 1347 dbSNP
rs944612149 1348 dbSNP
rs1000707611 1352 dbSNP
rs777355522 1357 dbSNP
rs1409089888 1361 dbSNP
rs1240136198 1362 dbSNP
rs767202169 1366 dbSNP
rs994694825 1371 dbSNP
rs1386478 1372 dbSNP
rs904975273 1374 dbSNP
rs1002358007 1389 dbSNP
rs567441895 1398 dbSNP
rs529994438 1399 dbSNP
rs1263889374 1407 dbSNP
rs1462689343 1411 dbSNP
rs950483472 1412 dbSNP
rs1014478801 1413 dbSNP
rs1180117272 1420 dbSNP
rs538190011 1425 dbSNP
rs1419455115 1427 dbSNP
rs967590351 1435 dbSNP
rs1409353792 1440 dbSNP
rs978936561 1453 dbSNP
rs780248151 1471 dbSNP
rs1265949410 1476 dbSNP
rs1227718228 1483 dbSNP
rs548540550 1488 dbSNP
rs986585295 1489 dbSNP
rs1367216899 1491 dbSNP
rs1289699663 1502 dbSNP
rs1176681340 1503 dbSNP
rs566640525 1527 dbSNP
rs1433096259 1528 dbSNP
rs768735998 1540 dbSNP
rs1407736393 1541 dbSNP
rs879681720 1549 dbSNP
rs534015994 1558 dbSNP
rs552344802 1561 dbSNP
rs954235566 1570 dbSNP
rs1402048035 1572 dbSNP
rs987410424 1580 dbSNP
rs1392356012 1583 dbSNP
rs570913528 1584 dbSNP
rs150736443 1585 dbSNP
rs1461748814 1588 dbSNP
rs1042470897 1591 dbSNP
rs722927 1596 dbSNP
rs936696074 1599 dbSNP
rs930538187 1602 dbSNP
rs1284143073 1605 dbSNP
rs895087195 1608 dbSNP
rs1325770366 1611 dbSNP
rs1453798101 1612 dbSNP
rs1208044016 1617 dbSNP
rs1013511673 1632 dbSNP
rs770871606 1642 dbSNP
rs78267260 1643 dbSNP
rs1004605218 1655 dbSNP
rs535715525 1661 dbSNP
rs1016050847 1665 dbSNP
rs904984518 1671 dbSNP
rs1249411585 1672 dbSNP
rs1387909239 1673 dbSNP
rs182559802 1675 dbSNP
rs1056594220 1678 dbSNP
rs995882359 1688 dbSNP
rs1028573164 1689 dbSNP
rs954407730 1693 dbSNP
rs1252025575 1696 dbSNP
rs987075323 1699 dbSNP
rs1340356296 1702 dbSNP
rs1274232674 1703 dbSNP
rs1020179128 1713 dbSNP
rs753955778 1713 dbSNP
rs1396034300 1714 dbSNP
rs978127451 1723 dbSNP
rs1374669282 1725 dbSNP
rs1174686026 1727 dbSNP
rs896221775 1734 dbSNP
rs866874832 1736 dbSNP
rs1310362866 1739 dbSNP
rs748484892 1766 dbSNP
rs1369153791 1774 dbSNP
rs758887014 1777 dbSNP
rs572257700 1788 dbSNP
rs1167595410 1793 dbSNP
rs1303999983 1794 dbSNP
rs546385840 1805 dbSNP
rs564566920 1809 dbSNP
rs1162427554 1810 dbSNP
rs1000366526 1813 dbSNP
rs990746455 1820 dbSNP
rs1178840787 1823 dbSNP
rs916588108 1825 dbSNP
rs1251102602 1834 dbSNP
rs1223511353 1837 dbSNP
rs1361862133 1839 dbSNP
rs113882887 1845 dbSNP
rs1244484386 1846 dbSNP
rs1318087085 1859 dbSNP
rs953640870 1862 dbSNP
rs576870267 1864 dbSNP
rs1046323791 1866 dbSNP
rs986248842 1872 dbSNP
rs544003811 1882 dbSNP
rs1348100152 1887 dbSNP
rs778338700 1889 dbSNP
rs1405250204 1890 dbSNP
rs562453443 1892 dbSNP
rs200065097 1896 dbSNP
rs1270623321 1898 dbSNP
rs1364112953 1899 dbSNP
rs1019468570 1900 dbSNP
rs1161303645 1914 dbSNP
rs370247068 1917 dbSNP
rs1411417435 1918 dbSNP
rs747135215 1920 dbSNP
rs1453585423 1924 dbSNP
rs1265490915 1927 dbSNP
rs1209422575 1933 dbSNP
rs529732688 1941 dbSNP
rs1262803417 1946 dbSNP
rs1227096622 1953 dbSNP
rs1329071916 1954 dbSNP
rs775289335 1957 dbSNP
rs1223559072 1968 dbSNP
rs1332279421 1969 dbSNP
rs1190237933 1970 dbSNP
rs1419668496 1975 dbSNP
rs762641266 1978 dbSNP
rs1429757395 1985 dbSNP
rs1171108909 1988 dbSNP
rs919257353 1990 dbSNP
rs548478767 2002 dbSNP
rs1429540560 2008 dbSNP
rs1387784040 2009 dbSNP
rs560466833 2016 dbSNP
rs1164568294 2022 dbSNP
rs574908089 2028 dbSNP
rs995936263 2045 dbSNP
rs1351955395 2049 dbSNP
rs926497040 2050 dbSNP
rs937866590 2056 dbSNP
rs552344249 2059 dbSNP
rs1434646698 2063 dbSNP
rs1056287507 2066 dbSNP
rs570580879 2067 dbSNP
rs538319299 2068 dbSNP
rs896275498 2075 dbSNP
rs28533721 2079 dbSNP
rs1042040475 2084 dbSNP
rs771158080 2085 dbSNP
rs1008869416 2101 dbSNP
rs903496766 2103 dbSNP
rs1272504356 2110 dbSNP
rs1232159406 2121 dbSNP
rs1019886851 2123 dbSNP
rs1299605341 2124 dbSNP
rs1432603178 2126 dbSNP
rs1295333839 2127 dbSNP
rs568085612 2130 dbSNP
rs144396591 2136 dbSNP
rs1337339492 2138 dbSNP
rs978262841 2141 dbSNP
rs1400166167 2142 dbSNP
rs751044900 2150 dbSNP
rs1462740106 2151 dbSNP
rs1392232242 2158 dbSNP
rs1186867888 2168 dbSNP
rs1033654680 2173 dbSNP
rs1293720795 2177 dbSNP
rs115184407 2179 dbSNP
rs1220442957 2180 dbSNP
rs958074796 2181 dbSNP
rs1275959731 2188 dbSNP
rs1008167235 2189 dbSNP
rs1342478073 2194 dbSNP
rs1186072881 2197 dbSNP
rs796358333 2198 dbSNP
rs1341218757 2205 dbSNP
rs966155958 2210 dbSNP
rs1246764538 2224 dbSNP
rs141062409 2235 dbSNP
rs1338616261 2242 dbSNP
rs1333649411 2247 dbSNP
rs1184731617 2256 dbSNP
rs1392067483 2257 dbSNP
rs1416485632 2259 dbSNP
rs1166960726 2269 dbSNP
rs949442082 2272 dbSNP
rs1026325778 2273 dbSNP
rs1386318468 2275 dbSNP
rs982419208 2287 dbSNP
rs1472121975 2289 dbSNP
rs187111294 2296 dbSNP
rs984791794 2297 dbSNP
rs539792451 2306 dbSNP
rs1164350800 2307 dbSNP
rs757748903 2317 dbSNP
rs1237377367 2318 dbSNP
rs1183120978 2319 dbSNP
rs78111301 2338 dbSNP
rs1202596501 2342 dbSNP
rs1341014755 2347 dbSNP
rs768051966 2357 dbSNP
rs865884711 2359 dbSNP
rs992442902 2360 dbSNP
rs899002839 2371 dbSNP
rs931697991 2376 dbSNP
rs917711832 2380 dbSNP
rs945138911 2386 dbSNP
rs1352413246 2387 dbSNP
rs1306253763 2398 dbSNP
rs1008600263 2400 dbSNP
rs1042094756 2417 dbSNP
rs576594913 2428 dbSNP
rs1325989505 2447 dbSNP
rs544263580 2453 dbSNP
rs750817894 2462 dbSNP
rs1285865453 2470 dbSNP
rs1376784843 2471 dbSNP
rs1413621806 2483 dbSNP
rs1179374656 2510 dbSNP
rs1482553132 2521 dbSNP
rs1227458924 2524 dbSNP
rs1284554572 2530 dbSNP
rs889398694 2532 dbSNP
rs574440699 2537 dbSNP
rs756472934 2538 dbSNP
rs901977864 2546 dbSNP
rs1331113996 2547 dbSNP
rs541858192 2556 dbSNP
rs1461369366 2557 dbSNP
rs1026425176 2561 dbSNP
rs1023744572 2569 dbSNP
rs1276856687 2574 dbSNP
rs971134456 2577 dbSNP
rs1319388497 2579 dbSNP
rs982170057 2587 dbSNP
rs907876092 2595 dbSNP
rs1156369734 2598 dbSNP
rs952149974 2607 dbSNP
rs961918486 2609 dbSNP
rs1193108086 2619 dbSNP
rs1425189235 2625 dbSNP
rs1487268 2628 dbSNP
rs374489265 2630 dbSNP
rs1245969232 2631 dbSNP
rs1033683742 2641 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000330212.3 | 3UTR | AUAGGAUUUUGGAGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38974 Chronic obstructive pulmonary disease -0.555 2.0e-3 -0.690 6.8e-5 25 Click to see details
GSE38226 Liver fibrosis 0.506 9.6e-3 0.513 8.7e-3 21 Click to see details
GSE28260 Renal cortex and medulla -0.476 5.0e-2 -0.609 1.4e-2 13 Click to see details
GSE21687 Ependynoma primary tumors -0.189 6.7e-2 -0.164 9.8e-2 64 Click to see details
GSE19350 CNS germ cell tumors -0.34 1.4e-1 -0.084 4.0e-1 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.193 2.1e-1 -0.140 2.8e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.161 2.3e-1 0.183 2.0e-1 24 Click to see details
GSE28544 Breast cancer 0.151 2.4e-1 0.159 2.3e-1 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.113 3.0e-1 -0.187 2.0e-1 23 Click to see details
GSE32688 Pancreatic cancer -0.022 4.5e-1 -0.033 4.3e-1 32 Click to see details
GSE32688 Pancreatic cancer -0.022 4.5e-1 -0.033 4.3e-1 32 Click to see details
GSE32688 Pancreatic cancer -0.022 4.5e-1 -0.033 4.3e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.434 0 0.438 0 42 Click to see details
PAAD 0.74 0.13 0.800 0.1 4 Click to see details
BLCA -0.734 0.13 -0.400 0.3 4 Click to see details
STAD 0.177 0.22 -0.003 0.49 21 Click to see details
PRAD 0.114 0.23 0.109 0.24 46 Click to see details
HNSC -0.183 0.23 -0.046 0.43 18 Click to see details
KIRP -0.167 0.23 -0.121 0.3 21 Click to see details
CHOL 0.31 0.27 0.600 0.1 6 Click to see details
LUAD -0.407 0.3 -0.600 0.2 4 Click to see details
LIHC -0.099 0.3 0.016 0.47 30 Click to see details
KIRC -0.076 0.31 -0.048 0.38 43 Click to see details
LUSC 0.078 0.34 0.079 0.34 30 Click to see details
ESCA -0.135 0.36 -0.309 0.19 10 Click to see details
UCEC -0.051 0.43 0.071 0.4 16 Click to see details
THCA -0.027 0.43 0.012 0.47 45 Click to see details
KICH 0.001 0.5 -0.150 0.3 15 Click to see details
KICH 0.001 0.5 -0.150 0.3 15 Click to see details
KICH 0.001 0.5 -0.150 0.3 15 Click to see details
KICH 0.001 0.5 -0.150 0.3 15 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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