pre-miRNA Information
pre-miRNA hsa-mir-452   
Genomic Coordinates chrX: 151959628 - 151959712
Synonyms MIRN452, hsa-mir-452, MIR452
Description Homo sapiens miR-452 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-452-3p
Sequence 58| CUCAUCUGCAAAGAAGUAAGUG |79
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 X - 151959644 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757928550 3 dbSNP
rs1324216965 6 dbSNP
rs1390793899 13 dbSNP
rs899383242 17 dbSNP
rs747858567 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FAM181B   
Synonyms -
Description family with sequence similarity 181 member B
Transcript NM_175885   
Expression
Putative miRNA Targets on FAM181B
3'UTR of FAM181B
(miRNA target sites are highlighted)
>FAM181B|NM_175885|3'UTR
   1 CTTCGAGGCACGCTTCCCTTCATTAGAGACGGCTGTGGAGAGCGCCGCGCCTCCGTGGGTTTCTCCTAAATCTGAAGAAC
  81 GATGGGAAAATGCACGTGGAGATGAAACCAGATTTTTAAAAATTCAATTAATAAAAGCAACTTCAGAAAAAAGAGATGAA
 161 GACGAGTTGGGGATTGTTTAATCACAACCTCAAGTGTTAAAACAAAAACAAACAAACACGTTTGTAGGTTCTTACTGGAC
 241 CAGAGGAGTCAAGAAACCAAGATGGTTTGGGGTATGGGGTGGGGACGGCAAAAGGGGTAAGAGCTGGCTTCTGTAGCCAC
 321 CTGTCCCTTCTATTTTTCAGCGAAGGTCAGTGTATTTAGTGTAATTACCCCTTCTAAACAGTGTCCTAGTCCCTCCCTTC
 401 CCTCTCCTTGAGTGCATTTTGAATTAAAGCCTATATTGAAAAGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' guGAAUG---AAGAA--AC---GUCUACUc 5'
            :||::   |||||  ||   |||| || 
Target 5' cgTTTGTAGGTTCTTACTGGACCAGAGGAg 3'
219 - 248 122.00 -12.80
2
miRNA  3' gugaaugaagaaacgUCUACUc 5'
                         |||||| 
Target 5' ggaaaatgcacgtggAGATGAa 3'
85 - 106 120.00 -9.10
3
miRNA  3' gugaaugaagaaacgUCUACUc 5'
                         |||||| 
Target 5' aacttcagaaaaaagAGATGAa 3'
139 - 160 120.00 -6.44
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26975758 4 COSMIC
COSN30117810 11 COSMIC
COSN30688949 12 COSMIC
COSN30459054 17 COSMIC
COSN30133849 43 COSMIC
COSN13353086 44 COSMIC
COSN31496979 44 COSMIC
COSN32074266 47 COSMIC
COSN26441656 49 COSMIC
COSN30181145 51 COSMIC
COSN31502255 55 COSMIC
COSN28649151 74 COSMIC
COSN30133212 80 COSMIC
COSN30128541 95 COSMIC
COSN28190903 108 COSMIC
COSN5310649 236 COSMIC
COSN8874799 359 COSMIC
COSN23605583 396 COSMIC
COSN5310648 408 COSMIC
COSN32220384 536 COSMIC
COSN29906508 986 COSMIC
COSN19445542 1914 COSMIC
COSN5921337 1935 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1241961641 1 dbSNP
rs1194732421 2 dbSNP
rs1470228512 7 dbSNP
rs1182290639 10 dbSNP
rs1271294661 11 dbSNP
rs1452809989 13 dbSNP
rs1213174931 16 dbSNP
rs1467705509 17 dbSNP
rs778359483 20 dbSNP
rs1275349568 22 dbSNP
rs926591476 24 dbSNP
rs1213090692 25 dbSNP
rs1296923362 26 dbSNP
rs1338499574 27 dbSNP
rs200966416 33 dbSNP
rs963093778 38 dbSNP
rs114353631 40 dbSNP
rs748478892 43 dbSNP
rs779294924 44 dbSNP
rs1302325242 46 dbSNP
rs1442266212 48 dbSNP
rs1042266138 51 dbSNP
rs1234849258 52 dbSNP
rs983381773 54 dbSNP
rs540955833 55 dbSNP
rs1237657361 71 dbSNP
rs3780 74 dbSNP
rs998397717 76 dbSNP
rs899514956 79 dbSNP
rs750637763 81 dbSNP
rs772168430 112 dbSNP
rs572653243 117 dbSNP
rs1018336728 126 dbSNP
rs1284735920 127 dbSNP
rs1233309710 141 dbSNP
rs1268366243 144 dbSNP
rs999848748 149 dbSNP
rs937714457 155 dbSNP
rs1313610008 156 dbSNP
rs1298683806 157 dbSNP
rs1372967478 158 dbSNP
rs1462957122 163 dbSNP
rs904300339 168 dbSNP
rs1392733645 176 dbSNP
rs908870635 182 dbSNP
rs1217835496 185 dbSNP
rs1324781889 186 dbSNP
rs1345204369 187 dbSNP
rs984360380 189 dbSNP
rs1041459607 194 dbSNP
rs1259988379 196 dbSNP
rs554450973 200 dbSNP
rs1212888592 202 dbSNP
rs1266208695 209 dbSNP
rs1402475481 213 dbSNP
rs1184788933 219 dbSNP
rs372639261 219 dbSNP
rs558085460 219 dbSNP
rs1288417404 224 dbSNP
rs1478228089 236 dbSNP
rs1196432881 237 dbSNP
rs895613997 246 dbSNP
rs1379622234 264 dbSNP
rs1056984006 278 dbSNP
rs374151454 286 dbSNP
rs1371628059 287 dbSNP
rs1174141254 289 dbSNP
rs1461209763 294 dbSNP
rs1166146275 295 dbSNP
rs1479995691 306 dbSNP
rs1249113456 314 dbSNP
rs1424158555 315 dbSNP
rs1195534045 319 dbSNP
rs1286812087 321 dbSNP
rs1360651605 326 dbSNP
rs1487294840 330 dbSNP
rs1400120495 341 dbSNP
rs757068852 346 dbSNP
rs75304464 351 dbSNP
rs1313166626 374 dbSNP
rs866629059 380 dbSNP
rs571456849 385 dbSNP
rs1488646699 389 dbSNP
rs941356297 389 dbSNP
rs1253893102 391 dbSNP
rs559239707 393 dbSNP
rs985552688 397 dbSNP
rs1255980166 400 dbSNP
rs909989226 401 dbSNP
rs1182751415 413 dbSNP
rs1416387899 415 dbSNP
rs1209065629 416 dbSNP
rs982882721 430 dbSNP
rs1156450718 431 dbSNP
rs1359555453 433 dbSNP
rs1419720021 443 dbSNP
rs191303825 445 dbSNP
rs922738711 450 dbSNP
rs1279281069 451 dbSNP
rs1220830522 452 dbSNP
rs1339127145 461 dbSNP
rs1303424490 465 dbSNP
rs1381031708 468 dbSNP
rs571977398 470 dbSNP
rs145469223 480 dbSNP
rs964314944 486 dbSNP
rs762745287 487 dbSNP
rs1354729395 488 dbSNP
rs1000847896 489 dbSNP
rs187572073 495 dbSNP
rs1485421430 497 dbSNP
rs968411309 503 dbSNP
rs1239759920 518 dbSNP
rs1301162276 524 dbSNP
rs1020849745 526 dbSNP
rs139556739 542 dbSNP
rs1009908657 543 dbSNP
rs1379261221 549 dbSNP
rs1439923761 551 dbSNP
rs895664783 553 dbSNP
rs1401272941 554 dbSNP
rs896318962 559 dbSNP
rs1056868737 569 dbSNP
rs1334717471 576 dbSNP
rs1001304501 581 dbSNP
rs1439705240 582 dbSNP
rs1297401169 586 dbSNP
rs937756462 592 dbSNP
rs1449267850 598 dbSNP
rs114492200 600 dbSNP
rs1037614465 601 dbSNP
rs1281281019 612 dbSNP
rs1306297409 614 dbSNP
rs1048728385 617 dbSNP
rs928939718 620 dbSNP
rs918839803 622 dbSNP
rs1202453693 626 dbSNP
rs941395479 629 dbSNP
rs972954546 640 dbSNP
rs527413962 641 dbSNP
rs944236341 645 dbSNP
rs1427099823 650 dbSNP
rs1047184475 655 dbSNP
rs930022658 658 dbSNP
rs985974604 660 dbSNP
rs1200952424 666 dbSNP
rs1169956672 671 dbSNP
rs1400759414 676 dbSNP
rs1467024299 683 dbSNP
rs954174618 689 dbSNP
rs922664386 698 dbSNP
rs1251258322 705 dbSNP
rs775128070 707 dbSNP
rs964199168 708 dbSNP
rs551647107 712 dbSNP
rs566327633 714 dbSNP
rs1214483064 716 dbSNP
rs1259314949 718 dbSNP
rs150573848 719 dbSNP
rs533018716 727 dbSNP
rs960852876 736 dbSNP
rs1450692948 745 dbSNP
rs1198885709 748 dbSNP
rs1474181494 767 dbSNP
rs1377963151 770 dbSNP
rs1019919486 779 dbSNP
rs1333531263 780 dbSNP
rs1033534920 784 dbSNP
rs1395575205 789 dbSNP
rs1163623288 794 dbSNP
rs1009958893 797 dbSNP
rs959805613 799 dbSNP
rs1300331962 802 dbSNP
rs1390206166 803 dbSNP
rs1035389957 820 dbSNP
rs1406188492 825 dbSNP
rs1325845292 826 dbSNP
rs183341328 834 dbSNP
rs535099814 848 dbSNP
rs1001354794 850 dbSNP
rs534100694 854 dbSNP
rs1283984297 864 dbSNP
rs1038023982 865 dbSNP
rs1006102031 866 dbSNP
rs888465042 880 dbSNP
rs1047119697 881 dbSNP
rs1182472450 887 dbSNP
rs929950693 889 dbSNP
rs1048759864 890 dbSNP
rs142690635 891 dbSNP
rs759305138 894 dbSNP
rs897486084 895 dbSNP
rs993160374 895 dbSNP
rs1473042345 899 dbSNP
rs1176336934 902 dbSNP
rs1165198705 907 dbSNP
rs539466678 934 dbSNP
rs942866330 942 dbSNP
rs911360833 945 dbSNP
rs1419126194 950 dbSNP
rs1298887156 953 dbSNP
rs1436849253 954 dbSNP
rs1250304841 977 dbSNP
rs1037717273 980 dbSNP
rs776398575 985 dbSNP
rs947638783 986 dbSNP
rs771961393 989 dbSNP
rs781048895 1001 dbSNP
rs1290167443 1004 dbSNP
rs1341410449 1006 dbSNP
rs1245341358 1009 dbSNP
rs1354427293 1010 dbSNP
rs1311535119 1012 dbSNP
rs1054938940 1014 dbSNP
rs1285545223 1020 dbSNP
rs1351097629 1023 dbSNP
rs1238710161 1027 dbSNP
rs1286128428 1035 dbSNP
rs1444924368 1037 dbSNP
rs1208636328 1040 dbSNP
rs913466538 1043 dbSNP
rs1049940656 1045 dbSNP
rs925361997 1046 dbSNP
rs932774565 1046 dbSNP
rs979509804 1047 dbSNP
rs1159536806 1048 dbSNP
rs966735058 1050 dbSNP
rs913892776 1051 dbSNP
rs191725871 1053 dbSNP
rs543139125 1056 dbSNP
rs1403574573 1057 dbSNP
rs1398118431 1058 dbSNP
rs770655490 1061 dbSNP
rs1374129405 1068 dbSNP
rs1445566813 1069 dbSNP
rs992544695 1070 dbSNP
rs1035440475 1074 dbSNP
rs1230466378 1079 dbSNP
rs1255297524 1080 dbSNP
rs1033980255 1081 dbSNP
rs1201905483 1087 dbSNP
rs572611010 1090 dbSNP
rs979780690 1092 dbSNP
rs1002046369 1095 dbSNP
rs1388535204 1102 dbSNP
rs146276571 1106 dbSNP
rs1027393073 1108 dbSNP
rs1378654781 1109 dbSNP
rs1016068579 1111 dbSNP
rs1166722692 1112 dbSNP
rs201956439 1114 dbSNP
rs375802524 1114 dbSNP
rs1466506446 1122 dbSNP
rs1006450691 1127 dbSNP
rs545623789 1129 dbSNP
rs1378695978 1135 dbSNP
rs886388613 1136 dbSNP
rs1377793170 1138 dbSNP
rs1200060481 1139 dbSNP
rs1026229844 1144 dbSNP
rs994208885 1145 dbSNP
rs774509207 1152 dbSNP
rs769219144 1153 dbSNP
rs1041159698 1174 dbSNP
rs942772360 1183 dbSNP
rs475021 1187 dbSNP
rs1190632262 1191 dbSNP
rs1222471721 1193 dbSNP
rs556596483 1194 dbSNP
rs780245444 1199 dbSNP
rs1043253143 1200 dbSNP
rs947529348 1202 dbSNP
rs1268134227 1203 dbSNP
rs1435052782 1204 dbSNP
rs575196084 1215 dbSNP
rs925435176 1218 dbSNP
rs1043862702 1223 dbSNP
rs989017918 1225 dbSNP
rs945426422 1228 dbSNP
rs913944679 1239 dbSNP
rs1456050853 1249 dbSNP
rs756153719 1253 dbSNP
rs1350261410 1280 dbSNP
rs1275624162 1295 dbSNP
rs1276167535 1299 dbSNP
rs938350051 1301 dbSNP
rs928267704 1302 dbSNP
rs745900327 1304 dbSNP
rs1279877278 1309 dbSNP
rs61254438 1312 dbSNP
rs969859164 1316 dbSNP
rs746681655 1323 dbSNP
rs1266304854 1325 dbSNP
rs1016415819 1333 dbSNP
rs1489493237 1335 dbSNP
rs567130415 1348 dbSNP
rs1263014669 1354 dbSNP
rs939309288 1362 dbSNP
rs926600414 1367 dbSNP
rs1295836241 1372 dbSNP
rs369730732 1372 dbSNP
rs984541 1379 dbSNP
rs1353598 1380 dbSNP
rs200262314 1381 dbSNP
rs367548040 1381 dbSNP
rs879576812 1381 dbSNP
rs1368704066 1387 dbSNP
rs1027425551 1391 dbSNP
rs1295820394 1392 dbSNP
rs1173905745 1394 dbSNP
rs1026239332 1395 dbSNP
rs1476828073 1399 dbSNP
rs1300035024 1407 dbSNP
rs141495002 1412 dbSNP
rs1199107986 1417 dbSNP
rs901187904 1441 dbSNP
rs138537841 1442 dbSNP
rs1265918732 1446 dbSNP
rs1285379680 1448 dbSNP
rs80305021 1455 dbSNP
rs777422426 1457 dbSNP
rs1043526791 1466 dbSNP
rs1483098490 1477 dbSNP
rs947619474 1485 dbSNP
rs1019078662 1487 dbSNP
rs569066583 1493 dbSNP
rs1446438434 1497 dbSNP
rs1156522063 1501 dbSNP
rs1379152556 1510 dbSNP
rs758432281 1525 dbSNP
rs1202460717 1529 dbSNP
rs145963373 1547 dbSNP
rs1282442971 1554 dbSNP
rs188296051 1559 dbSNP
rs1381148278 1567 dbSNP
rs1444831665 1570 dbSNP
rs1308852385 1574 dbSNP
rs928320181 1575 dbSNP
rs1028608448 1585 dbSNP
rs997089527 1586 dbSNP
rs1044098918 1596 dbSNP
rs904046331 1600 dbSNP
rs1211195401 1606 dbSNP
rs1258125844 1608 dbSNP
rs561114302 1618 dbSNP
rs543050045 1619 dbSNP
rs183803230 1620 dbSNP
rs1237243936 1624 dbSNP
rs1439724539 1627 dbSNP
rs1178464129 1628 dbSNP
rs1422895231 1638 dbSNP
rs752548827 1640 dbSNP
rs1335612522 1645 dbSNP
rs1176789269 1658 dbSNP
rs1043928979 1659 dbSNP
rs1404878294 1661 dbSNP
rs1330873091 1662 dbSNP
rs1377961402 1664 dbSNP
rs945492080 1668 dbSNP
rs1273171748 1670 dbSNP
rs1367072339 1673 dbSNP
rs1220314526 1682 dbSNP
rs892553450 1688 dbSNP
rs909004450 1702 dbSNP
rs984910905 1705 dbSNP
rs1256984581 1706 dbSNP
rs1056948208 1715 dbSNP
rs1206250918 1723 dbSNP
rs1244470435 1725 dbSNP
rs1185230876 1726 dbSNP
rs567492854 1738 dbSNP
rs759136727 1739 dbSNP
rs980677049 1757 dbSNP
rs149493187 1760 dbSNP
rs919064417 1781 dbSNP
rs1475368018 1784 dbSNP
rs545586970 1787 dbSNP
rs753355262 1795 dbSNP
rs1321907619 1800 dbSNP
rs578100565 1801 dbSNP
rs1437346168 1825 dbSNP
rs556746356 1827 dbSNP
rs1006924179 1828 dbSNP
rs1339137038 1830 dbSNP
rs555254029 1833 dbSNP
rs1021714713 1834 dbSNP
rs920485164 1841 dbSNP
rs544576384 1843 dbSNP
rs1320528194 1844 dbSNP
rs1215929528 1848 dbSNP
rs7120212 1857 dbSNP
rs60119381 1859 dbSNP
rs962149616 1862 dbSNP
rs891976327 1867 dbSNP
rs1221697473 1873 dbSNP
rs1018738584 1879 dbSNP
rs1270603816 1881 dbSNP
rs554902800 1882 dbSNP
rs1213980041 1884 dbSNP
rs987619608 1885 dbSNP
rs1192933835 1887 dbSNP
rs1379761288 1899 dbSNP
rs1476296195 1903 dbSNP
rs1285493551 1907 dbSNP
rs953102682 1910 dbSNP
rs1053191881 1911 dbSNP
rs1305041010 1916 dbSNP
rs1359124203 1920 dbSNP
rs1449776331 1920 dbSNP
rs1399926527 1922 dbSNP
rs1381631883 1937 dbSNP
rs533548114 1939 dbSNP
rs760183194 1943 dbSNP
rs907500539 1946 dbSNP
rs1045040606 1952 dbSNP
rs1446309022 1958 dbSNP
rs948416945 1962 dbSNP
rs765730530 1971 dbSNP
rs1245996704 1972 dbSNP
rs1168773638 1973 dbSNP
rs1048819082 1993 dbSNP
rs1263884207 1996 dbSNP
rs1409935953 1996 dbSNP
rs1448471027 1997 dbSNP
rs1415133176 2000 dbSNP
rs1185182534 2003 dbSNP
rs1237053976 2004 dbSNP
rs191147873 2005 dbSNP
rs1473257520 2012 dbSNP
rs1165771025 2015 dbSNP
rs1378516987 2016 dbSNP
rs557416418 2025 dbSNP
rs371705976 2027 dbSNP
rs1159728258 2028 dbSNP
rs929017826 2029 dbSNP
rs1394580648 2045 dbSNP
rs539546055 2047 dbSNP
rs904111785 2049 dbSNP
rs975941337 2050 dbSNP
rs1022514469 2055 dbSNP
rs1316767633 2056 dbSNP
rs1009777054 2060 dbSNP
rs1261198562 2061 dbSNP
rs1352756165 2064 dbSNP
rs892620665 2067 dbSNP
rs1277641092 2070 dbSNP
rs1442828148 2076 dbSNP
rs1157624557 2078 dbSNP
rs1242773750 2079 dbSNP
rs1056579441 2080 dbSNP
rs1179557800 2084 dbSNP
rs965858547 2085 dbSNP
rs550821637 2090 dbSNP
rs1230997887 2095 dbSNP
rs1203524682 2102 dbSNP
rs568952559 2105 dbSNP
rs1291892105 2115 dbSNP
rs1471190459 2117 dbSNP
rs910507502 2121 dbSNP
rs986411451 2122 dbSNP
rs905251448 2124 dbSNP
rs1397718154 2127 dbSNP
rs550790563 2128 dbSNP
rs1307102813 2132 dbSNP
rs112946963 2137 dbSNP
rs368066422 2138 dbSNP
rs1323928096 2142 dbSNP
rs930613563 2148 dbSNP
rs535345124 2153 dbSNP
rs1457492033 2163 dbSNP
rs1011634204 2166 dbSNP
rs1309337164 2168 dbSNP
rs117148109 2169 dbSNP
rs1031709677 2170 dbSNP
rs1036237113 2172 dbSNP
rs1378746936 2174 dbSNP
rs1481602372 2186 dbSNP
rs1296859127 2197 dbSNP
rs1003036438 2199 dbSNP
rs907326010 2204 dbSNP
rs1305428335 2205 dbSNP
rs940569139 2208 dbSNP
rs1397605206 2212 dbSNP
rs371621935 2222 dbSNP
rs1464768974 2224 dbSNP
rs1298460205 2244 dbSNP
rs527705123 2248 dbSNP
rs1013558668 2249 dbSNP
rs560508086 2253 dbSNP
rs1322768698 2257 dbSNP
rs1159294050 2259 dbSNP
rs1441824617 2266 dbSNP
rs1225054593 2277 dbSNP
rs1405998036 2283 dbSNP
rs1317139949 2284 dbSNP
rs1228384380 2286 dbSNP
rs987263323 2291 dbSNP
rs1049229820 2293 dbSNP
rs1487520087 2308 dbSNP
rs1209355673 2318 dbSNP
rs1270150629 2326 dbSNP
rs768896839 2329 dbSNP
rs1176442451 2337 dbSNP
rs185878995 2338 dbSNP
rs180678292 2347 dbSNP
rs1040141631 2356 dbSNP
rs763553841 2357 dbSNP
rs921645522 2361 dbSNP
rs1374466442 2371 dbSNP
rs1248399493 2385 dbSNP
rs978426077 2390 dbSNP
rs138266350 2395 dbSNP
rs1220245173 2398 dbSNP
rs189883006 2399 dbSNP
rs1296307350 2400 dbSNP
rs1022587687 2406 dbSNP
rs754089093 2407 dbSNP
rs956915959 2410 dbSNP
rs566793733 2411 dbSNP
rs1292573410 2414 dbSNP
rs867743036 2415 dbSNP
rs1361767495 2416 dbSNP
rs73506323 2420 dbSNP
rs1368815219 2428 dbSNP
rs745952401 2435 dbSNP
rs150468270 2440 dbSNP
rs1162606013 2441 dbSNP
rs1385276059 2442 dbSNP
rs771204023 2445 dbSNP
rs568868165 2457 dbSNP
rs572482378 2464 dbSNP
rs1298903506 2466 dbSNP
rs1359861368 2468 dbSNP
rs1454063780 2474 dbSNP
rs971604946 2476 dbSNP
rs1376778421 2479 dbSNP
rs557377296 2482 dbSNP
rs1395667535 2484 dbSNP
rs140552571 2490 dbSNP
rs575304886 2492 dbSNP
rs899165858 2501 dbSNP
rs1013069986 2505 dbSNP
rs1036268231 2508 dbSNP
rs1218630489 2509 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000329203.3 | 3UTR | AAAAGAGAUGAAGACGAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38226 Liver fibrosis 0.562 4.0e-3 0.500 1.0e-2 21 Click to see details
GSE32688 Pancreatic cancer 0.437 6.2e-3 0.394 1.3e-2 32 Click to see details
GSE28260 Renal cortex and medulla -0.592 1.7e-2 -0.648 8.3e-3 13 Click to see details
GSE17306 Multiple myeloma -0.235 5.2e-2 0.415 1.5e-3 49 Click to see details
GSE26953 Aortic valvular endothelial cells -0.283 9.0e-2 -0.437 1.6e-2 24 Click to see details
GSE19350 CNS germ cell tumors -0.304 1.7e-1 0.154 3.2e-1 12 Click to see details
GSE27834 Pluripotent stem cells 0.248 1.8e-1 -0.056 4.2e-1 16 Click to see details
GSE14794 Lymphoblastoid cells 0.09 2.0e-1 0.056 3.0e-1 90 Click to see details
GSE21687 Ependynoma primary tumors 0.098 2.2e-1 0.116 1.8e-1 64 Click to see details
GSE28544 Breast cancer -0.144 2.5e-1 -0.232 1.4e-1 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.121 2.9e-1 -0.074 3.7e-1 23 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.12 3.1e-1 0.189 2.1e-1 20 Click to see details
GSE21849 B cell lymphoma -0.064 3.7e-1 -0.021 4.6e-1 29 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.004 4.9e-1 0.099 3.2e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.004 4.9e-1 0.099 3.2e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.004 4.9e-1 0.099 3.2e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.304 0 0.264 0.01 79 Click to see details
HNSC 0.349 0.01 0.347 0.01 42 Click to see details
THCA -0.217 0.05 -0.176 0.09 59 Click to see details
KIRP 0.283 0.06 0.197 0.14 31 Click to see details
LUSC 0.238 0.08 0.249 0.07 38 Click to see details
UCEC -0.259 0.14 -0.282 0.12 19 Click to see details
CHOL 0.371 0.16 0.150 0.35 9 Click to see details
BLCA 0.216 0.2 0.179 0.25 17 Click to see details
PRAD 0.122 0.2 0.160 0.14 48 Click to see details
ESCA 0.286 0.23 0.300 0.22 9 Click to see details
KIRC -0.082 0.26 -0.067 0.3 65 Click to see details
STAD -0.12 0.27 -0.178 0.18 29 Click to see details
PAAD -0.407 0.3 -0.400 0.3 4 Click to see details
CESC 0.562 0.31 0.500 0.33 3 Click to see details
LUAD 0.127 0.35 0.191 0.29 11 Click to see details
LIHC 0.051 0.36 0.039 0.4 49 Click to see details
KICH 0.013 0.48 -0.097 0.33 24 Click to see details
KICH 0.013 0.48 -0.097 0.33 24 Click to see details
KICH 0.013 0.48 -0.097 0.33 24 Click to see details
KICH 0.013 0.48 -0.097 0.33 24 Click to see details
87 hsa-miR-452-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT150000 MIDN midnolin 2 10
MIRT330600 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT358701 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT362854 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT447215 ATXN7 ataxin 7 2 2
MIRT466655 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT483979 PANK1 pantothenate kinase 1 2 8
MIRT485118 SF3B3 splicing factor 3b subunit 3 2 2
MIRT488864 AUTS8 Autism, susceptibility to, 8 2 2
MIRT492293 SH2B3 SH2B adaptor protein 3 2 2
MIRT492976 NCK2 NCK adaptor protein 2 2 2
MIRT497410 LRRC40 leucine rich repeat containing 40 2 2
MIRT511143 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT512650 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT513017 NSFL1C NSFL1 cofactor 2 6
MIRT520445 TSPAN2 tetraspanin 2 2 6
MIRT527995 NDNF neuron derived neurotrophic factor 2 2
MIRT528667 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT533512 TRIM71 tripartite motif containing 71 2 2
MIRT537404 FBXO47 F-box protein 47 2 2
MIRT538161 DCP2 decapping mRNA 2 2 2
MIRT539124 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT540666 MIS18A MIS18 kinetochore protein A 2 4
MIRT542948 GDF11 growth differentiation factor 11 2 2
MIRT547534 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT559033 C20orf24 chromosome 20 open reading frame 24 2 4
MIRT559554 ARF6 ADP ribosylation factor 6 2 2
MIRT570177 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT573149 ITGA9 integrin subunit alpha 9 2 2
MIRT575849 Rab1 RAB1A, member RAS oncogene family 1 1
MIRT611034 RRP1B ribosomal RNA processing 1B 2 2
MIRT616281 HMGB1 high mobility group box 1 2 2
MIRT618372 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619540 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT622303 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT622590 PRRG4 proline rich and Gla domain 4 2 2
MIRT624441 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT637089 KLRD1 killer cell lectin like receptor D1 2 2
MIRT639084 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639334 NINJ1 ninjurin 1 2 2
MIRT639798 EIF3E eukaryotic translation initiation factor 3 subunit E 2 2
MIRT640851 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT641628 KIAA1244 ARFGEF family member 3 1 1
MIRT642634 EPPIN epididymal peptidase inhibitor 2 2
MIRT643053 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643416 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT645586 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT647393 FAM181B family with sequence similarity 181 member B 2 2
MIRT649411 CDC14B cell division cycle 14B 2 2
MIRT649477 CLDN16 claudin 16 2 2
MIRT651307 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT651387 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT653411 SLC7A2 solute carrier family 7 member 2 2 2
MIRT654084 RSPH4A radial spoke head 4 homolog A 2 2
MIRT654613 PTPRM protein tyrosine phosphatase, receptor type M 2 2
MIRT655338 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT656173 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT657272 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 2
MIRT657881 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659875 CAPRIN1 cell cycle associated protein 1 2 2
MIRT662381 ICA1L islet cell autoantigen 1 like 2 4
MIRT666308 SLC22A3 solute carrier family 22 member 3 2 2
MIRT667274 NAV1 neuron navigator 1 2 2
MIRT667614 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT674242 NUP62 nucleoporin 62 2 4
MIRT690386 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT693402 NUDT16 nudix hydrolase 16 2 2
MIRT702503 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT708632 STMN4 stathmin 4 2 2
MIRT708839 SCAND3 zinc finger BED-type containing 9 1 1
MIRT709016 HSBP1 heat shock factor binding protein 1 2 2
MIRT709235 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710885 PARL presenilin associated rhomboid like 2 2
MIRT712262 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712573 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT715046 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT718905 GALR1 galanin receptor 1 2 2
MIRT719368 FEM1A fem-1 homolog A 2 2
MIRT719495 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719601 PRKX protein kinase, X-linked 2 2
MIRT719891 RRP36 ribosomal RNA processing 36 2 2
MIRT720063 ZNF449 zinc finger protein 449 2 2
MIRT721679 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT721724 VTI1A vesicle transport through interaction with t-SNAREs 1A 2 2
MIRT723370 ZNF470 zinc finger protein 470 2 2
MIRT724941 TXNL1 thioredoxin like 1 2 2
MIRT725302 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-452 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-452 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-452 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miR-452 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-mir-452 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-452-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-452-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-452-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (HCT8)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-452-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-452-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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