pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol DZIP1L   
Synonyms DZIP2, PKD5
Description DAZ interacting zinc finger protein 1 like
Transcript NM_173543   
Other Transcripts NM_001170538   
Expression
Putative miRNA Targets on DZIP1L
3'UTR of DZIP1L
(miRNA target sites are highlighted)
>DZIP1L|NM_173543|3'UTR
   1 TTCACCCCAGAAGCTAGCTGGCTAGAGGGTTAGCCTGGCTGGGGCCAGCTCAGGTCCACTTCAACAGAAGAGGCTGCTGG
  81 GCCTCTTGTCTTCACAAACAACCAAGAGATCATCCTCTTGGAGAGAAGCAGTGCAGGGAATGGATATGATCTCATCCCTC
 161 CTGACCTGTGAGGGGCCCTGCTGTAGATGGCCACAGGTGCCTGACTAGGAGCCCCTAGGTCCCCAGGCTTGAGAAAGGGT
 241 TAAAATAGAACCTCCAGGTAGTTTTCTTCCTCTACCTCCACATCCCCCCAAGACTGAAAAGAGTCACTAACTCTCTTTTC
 321 CCAAGCCTTTTATAAAACTGCAGGAACACTGTGGAGATGGTTCCTATCTGGGGTCCTTTTGGGGACATATGCCTCAGTCA
 401 GTCATTCAGTGATTGATCCAAAATTATTTACTGAGTGCCTACCTACTCTGCGCCAGGCTCTCTAGCCTCTCACTACTGAG
 481 TTAGGGTGCAGGCAGAGGCTGGGGCAGAATGTTTACAGCCAGTGCCAGCACAAGGTAGTAATCTAGTGACAGAGAACAGG
 561 GTGTTATGGGGAGCATATGAGAGGCCATCTATCCCAGCCTGGGTGATCCTGGAGAGTTTCCCAGGGTTGTGATATGTGGC
 641 AGGCCTACTCATGGGTGGGAAGGGAGGATGGCCACTTGGCTGGACCTTGTATCCCCAAAGGACCACACGTGTAATTTTTG
 721 ATATTATTTCCAAAATCAGGTTTTATACATAGCCATTGTATATTTTTAGTGTGAAAAACATTAATATATTATATGCAAAC
 801 ATTTAAATATAGTACAATGTTTTTAACTCTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacCCCACCCCUGUCUCCGAa 5'
             |||||  |:|||||||| 
Target 5' ttaGGGTGCAGGCAGAGGCTg 3'
481 - 501 170.00 -25.00
2
miRNA  3' gaccccacccCUGUCUCCGAa 5'
                    || ||||||| 
Target 5' cacttcaacaGA-AGAGGCTg 3'
57 - 76 142.00 -9.50
3
miRNA  3' gaCCCCACCCCUG-UCUCCGaa 5'
            |||| |   |: ||||||  
Target 5' atGGGGAGCATATGAGAGGCca 3'
566 - 587 131.00 -16.06
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30476044 3 COSMIC
COSN30489827 6 COSMIC
COSN30129550 20 COSMIC
COSN31572011 27 COSMIC
COSN26649430 52 COSMIC
COSN31505652 59 COSMIC
COSN30154662 68 COSMIC
COSN32052787 85 COSMIC
COSN30493125 148 COSMIC
COSN28201379 276 COSMIC
COSN20856945 326 COSMIC
COSN17181734 689 COSMIC
COSN31523463 759 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1396610498 5 dbSNP
rs1290080339 6 dbSNP
rs1321439917 11 dbSNP
rs756771119 18 dbSNP
rs1314629084 23 dbSNP
rs753347963 25 dbSNP
rs554947269 28 dbSNP
rs760057894 29 dbSNP
rs1476280820 33 dbSNP
rs752129083 37 dbSNP
rs766803101 44 dbSNP
rs763264845 45 dbSNP
rs367839366 51 dbSNP
rs1238838177 52 dbSNP
rs371231885 57 dbSNP
rs1411370036 66 dbSNP
rs552190367 67 dbSNP
rs1034506817 82 dbSNP
rs1164981687 93 dbSNP
rs902941506 99 dbSNP
rs1351317779 103 dbSNP
rs1041446332 109 dbSNP
rs1330142006 111 dbSNP
rs1379111052 113 dbSNP
rs949776921 119 dbSNP
rs918128253 136 dbSNP
rs532429109 142 dbSNP
rs1178722259 144 dbSNP
rs1449670038 146 dbSNP
rs569818046 153 dbSNP
rs926846335 155 dbSNP
rs557495548 164 dbSNP
rs1229309798 172 dbSNP
rs1292447941 173 dbSNP
rs1197199989 176 dbSNP
rs974059538 180 dbSNP
rs1021301245 181 dbSNP
rs1451439231 183 dbSNP
rs1200457922 212 dbSNP
rs140556026 214 dbSNP
rs151311173 217 dbSNP
rs1182283025 223 dbSNP
rs1415654099 238 dbSNP
rs1169454314 251 dbSNP
rs982869796 252 dbSNP
rs955629984 254 dbSNP
rs762651521 258 dbSNP
rs866868521 269 dbSNP
rs1364446658 270 dbSNP
rs1007958915 286 dbSNP
rs1359146045 288 dbSNP
rs1449364039 289 dbSNP
rs1286360738 290 dbSNP
rs775426386 303 dbSNP
rs1338841600 304 dbSNP
rs997059929 313 dbSNP
rs964006767 322 dbSNP
rs1241033668 325 dbSNP
rs561953016 338 dbSNP
rs1201909511 345 dbSNP
rs1277969857 349 dbSNP
rs999864189 360 dbSNP
rs541738097 366 dbSNP
rs1239010273 367 dbSNP
rs1487148382 370 dbSNP
rs1423969224 372 dbSNP
rs759616017 375 dbSNP
rs528442336 376 dbSNP
rs570106296 387 dbSNP
rs931231429 389 dbSNP
rs2291195 409 dbSNP
rs1415571899 420 dbSNP
rs1014035837 421 dbSNP
rs1399852367 426 dbSNP
rs377568656 434 dbSNP
rs1342662595 436 dbSNP
rs1231296777 437 dbSNP
rs1274369698 442 dbSNP
rs1397999998 443 dbSNP
rs1359840944 450 dbSNP
rs1056654643 451 dbSNP
rs141049999 452 dbSNP
rs1351403925 462 dbSNP
rs59771921 465 dbSNP
rs907870722 473 dbSNP
rs147741948 477 dbSNP
rs574910856 478 dbSNP
rs1247584831 490 dbSNP
rs1245640796 492 dbSNP
rs941613405 495 dbSNP
rs1478033527 503 dbSNP
rs34429764 505 dbSNP
rs938779211 505 dbSNP
rs908577793 511 dbSNP
rs982727681 514 dbSNP
rs555189321 516 dbSNP
rs1419600318 520 dbSNP
rs772247063 521 dbSNP
rs1362801334 534 dbSNP
rs1385330946 548 dbSNP
rs1323073350 557 dbSNP
rs534974012 561 dbSNP
rs566039419 563 dbSNP
rs980254312 567 dbSNP
rs1487585204 569 dbSNP
rs748203600 570 dbSNP
rs1401944292 571 dbSNP
rs1263180935 572 dbSNP
rs1217391231 581 dbSNP
rs1286507667 583 dbSNP
rs1356008001 591 dbSNP
rs1352506869 592 dbSNP
rs1276616210 593 dbSNP
rs72991157 617 dbSNP
rs768765853 620 dbSNP
rs538670414 622 dbSNP
rs964177242 625 dbSNP
rs1195005417 626 dbSNP
rs1235791450 631 dbSNP
rs189849921 634 dbSNP
rs1439654161 635 dbSNP
rs1179758484 641 dbSNP
rs1382568594 642 dbSNP
rs114147197 644 dbSNP
rs1019287639 650 dbSNP
rs1391787297 651 dbSNP
rs1008427068 665 dbSNP
rs889510876 666 dbSNP
rs749454852 680 dbSNP
rs184591456 686 dbSNP
rs1445974142 691 dbSNP
rs1309810911 694 dbSNP
rs568160449 699 dbSNP
rs1242410151 703 dbSNP
rs967277902 705 dbSNP
rs995328484 708 dbSNP
rs1019987900 709 dbSNP
rs1215131411 714 dbSNP
rs898432193 721 dbSNP
rs1456886793 729 dbSNP
rs1036941336 769 dbSNP
rs1253356901 775 dbSNP
rs1332932524 780 dbSNP
rs939924360 790 dbSNP
rs1014315563 795 dbSNP
rs895581564 803 dbSNP
rs758025792 809 dbSNP
rs79537884 810 dbSNP
rs1399654254 811 dbSNP
rs938765632 815 dbSNP
rs1002379998 817 dbSNP
rs1333428253 826 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccccacccCUGUCUCCGAa 5'
                    || ||||||| 
Target 5' ---------aGA-AGAGGCUg 3'
1 - 11
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000327532.2 | 3UTR | AGAAGAGGCUGCUGGGCCUCUUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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