pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol NADSYN1   
Synonyms -
Description NAD synthetase 1
Transcript NM_018161   
Expression
Putative miRNA Targets on NADSYN1
3'UTR of NADSYN1
(miRNA target sites are highlighted)
>NADSYN1|NM_018161|3'UTR
   1 GGCCGGTTCCTTCCTGGAGGCCTCCTGTCCTCGGGGACCCCAGCACCTCATCATCAGCATTGCTGGAGCCAAGGGTAGGA
  81 GCCCTACACTAGGAGCCCAGGATGGGACGGCGCATCAGCCGAGAGGGAGGGAACTTTTCAGTCAAATTCCTCAAAAAGAG
 161 GCTGGAATAAAGCCTGGGCTTAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccccaccccUGUCUCCGAa 5'
                     | ||||||| 
Target 5' aaattcctcaaAAAGAGGCTg 3'
144 - 164 142.00 -9.40
2
miRNA  3' gaccccaccccuGUCUCCGaa 5'
                      ::|||||  
Target 5' ccggttccttccTGGAGGCct 3'
3 - 23 105.00 -7.60
3
miRNA  3' gacCCCACCC--CUG----------UCUCCgaa 5'
             || ||||  |:|          |||||   
Target 5' ccaGGATGGGACGGCGCATCAGCCGAGAGGgag 3'
97 - 129 102.00 -20.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28875211 5 COSMIC
COSN28899268 18 COSMIC
COSN30504007 39 COSMIC
COSN31550634 98 COSMIC
COSN19726755 113 COSMIC
COSN26727594 122 COSMIC
COSN10091370 169 COSMIC
COSN10091371 170 COSMIC
COSN26435918 242 COSMIC
COSN1137378 244 COSMIC
COSN7018597 272 COSMIC
COSN1137379 291 COSMIC
COSN28443999 349 COSMIC
COSN19476457 441 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs377410682 2 dbSNP
rs575795916 3 dbSNP
rs376705127 5 dbSNP
rs369492727 6 dbSNP
rs1290613334 15 dbSNP
rs981876227 16 dbSNP
rs750976311 18 dbSNP
rs1351684640 19 dbSNP
rs1225930397 20 dbSNP
rs1283575105 22 dbSNP
rs761019568 24 dbSNP
rs766783232 26 dbSNP
rs1035760537 29 dbSNP
rs1387993446 29 dbSNP
rs372780881 33 dbSNP
rs536845215 34 dbSNP
rs950903423 37 dbSNP
rs1484781241 39 dbSNP
rs376987366 40 dbSNP
rs778440922 42 dbSNP
rs1454256628 43 dbSNP
rs1481604407 44 dbSNP
rs752127826 47 dbSNP
rs942194818 48 dbSNP
rs370141453 50 dbSNP
rs777568703 55 dbSNP
rs1174908347 58 dbSNP
rs747000541 59 dbSNP
rs1433675294 66 dbSNP
rs1173433923 67 dbSNP
rs1355459521 68 dbSNP
rs770792277 74 dbSNP
rs773623973 76 dbSNP
rs781137815 80 dbSNP
rs1372769279 81 dbSNP
rs749480526 82 dbSNP
rs768781946 84 dbSNP
rs763471223 85 dbSNP
rs762677113 89 dbSNP
rs774680772 90 dbSNP
rs761764749 94 dbSNP
rs1275135167 96 dbSNP
rs1309030345 100 dbSNP
rs1202417846 103 dbSNP
rs572915193 107 dbSNP
rs766585293 109 dbSNP
rs751948706 110 dbSNP
rs761179093 112 dbSNP
rs113681770 113 dbSNP
rs530591671 116 dbSNP
rs754226900 118 dbSNP
rs539906692 119 dbSNP
rs934374377 121 dbSNP
rs77697947 122 dbSNP
rs1382668591 124 dbSNP
rs1168708844 125 dbSNP
rs966410627 128 dbSNP
rs979165508 138 dbSNP
rs767989361 141 dbSNP
rs1456498734 143 dbSNP
rs190079892 148 dbSNP
rs937697559 152 dbSNP
rs1022822336 153 dbSNP
rs1467790510 153 dbSNP
rs12282141 159 dbSNP
rs990934096 166 dbSNP
rs756139634 173 dbSNP
rs918169242 174 dbSNP
rs905798357 175 dbSNP
rs544143989 177 dbSNP
rs949646553 179 dbSNP
rs1002871506 181 dbSNP
rs1383560578 182 dbSNP
rs1250425678 192 dbSNP
rs1248288336 198 dbSNP
rs1047900965 199 dbSNP
rs562791086 202 dbSNP
rs529904703 208 dbSNP
rs1355912637 210 dbSNP
rs1342473330 219 dbSNP
rs1255088859 221 dbSNP
rs942057792 223 dbSNP
rs1036133790 224 dbSNP
rs950754962 225 dbSNP
rs1434292592 227 dbSNP
rs548369523 229 dbSNP
rs996183089 230 dbSNP
rs1397966827 231 dbSNP
rs1016370821 233 dbSNP
rs560063119 234 dbSNP
rs974931787 236 dbSNP
rs113263840 241 dbSNP
rs1430481335 242 dbSNP
rs955165250 243 dbSNP
rs528615148 244 dbSNP
rs912177075 246 dbSNP
rs1369368516 254 dbSNP
rs547103429 260 dbSNP
rs181766110 261 dbSNP
rs1196087157 270 dbSNP
rs1483713559 271 dbSNP
rs1052772385 273 dbSNP
rs757501108 276 dbSNP
rs1360111950 289 dbSNP
rs748034346 291 dbSNP
rs914350526 293 dbSNP
rs947201988 296 dbSNP
rs779066101 297 dbSNP
rs1339718165 298 dbSNP
rs186136512 301 dbSNP
rs1410679481 302 dbSNP
rs1306289467 323 dbSNP
rs551338602 328 dbSNP
rs1032091225 330 dbSNP
rs1165566784 332 dbSNP
rs1472013309 335 dbSNP
rs905771918 341 dbSNP
rs1003169477 342 dbSNP
rs1182383912 347 dbSNP
rs1057067181 348 dbSNP
rs886410590 352 dbSNP
rs1473383818 354 dbSNP
rs1248935517 369 dbSNP
rs1203772884 371 dbSNP
rs959419512 374 dbSNP
rs1291922251 381 dbSNP
rs990488223 383 dbSNP
rs1279945719 385 dbSNP
rs1229202227 386 dbSNP
rs1286740983 389 dbSNP
rs917590436 396 dbSNP
rs1350604303 397 dbSNP
rs1004917418 401 dbSNP
rs1326037538 416 dbSNP
rs1016339390 426 dbSNP
rs983709042 431 dbSNP
rs1334869094 441 dbSNP
rs1340080411 447 dbSNP
rs963495856 457 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccccaccccUGUCUCCGAa 5'
                     | ||||||| 
Target 5' ----------aAAAGAGGCUg 3'
1 - 11
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000319023.2 | 3UTR | AAAAGAGGCUGGAAUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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