miRTarBase - #MIRT647780


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pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ASB8   
Synonyms PP14212
Description ankyrin repeat and SOCS box containing 8
Transcript NM_024095   
Expression
Putative miRNA Targets on ASB8
3'UTR of ASB8
(miRNA target sites are highlighted)		 
>ASB8|NM_024095|3'UTR
   1 CCGGAGAAGATGTTTGCACCATCGTGCAGGCAGCTCTGGGTGAGGTTGTCCCTGCAGTACTCCTTGTCACAGAAAACAGA
  81 AAAACAGTTGTTCCTGTTGTGTGGTTTATAGATTTCGAAGCAACATGTCACAACAATAACCTCCATAGCACCTCCCCTTC
 161 CCAAACCAAACAACCCAACAAAAAAAATCCCTCACTTTTGTTTTCTGTTTATTGCTTACCTGGCTTTTTATATTGCATTT
 241 TGCAAAAGAAGAGGTCTCCCTCAATCCTCCCCTTTAGGGAAGGAGTCAACAGTGTAACTAAATTTCTCTAGGAAGATGGA
 321 AAGTACTTAAATAATGTGTGTGTGGTTTTCCTTTGGGGACGTGGTTAACGGTCCAGAAGAATCCCTTCTAGAAAGCATTT
 401 TAGGCCAGCCATGGTGGCTCACGTCTGTAATCCCAGGACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGT
 481 TCGAGCCCAGCCTGACCAATATGATGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCATGCGCC
 561 TGTAATCCCAGCTACTCAGGAGGCTGAGACAGAAGAATCGCTTGAACCTGTGAGGCAGAGGTTGCAGTGAGCCAAGATCG
 641 CGCCATTGCACTCCAGCCTGGACAACAAGAGCAAAACTGTCTCAAAAAAAAAAAAAAAAAAAAAAAACCATTTTAATTGA
 721 TCTGTGAAAAAACTTAAGAAAATCACAATTTCAGCTAACAGCAATTGTGTCCCAAAGATGAAGATACTATAACCTCAAAT
 801 GGTGCAGATCCAGAACTGGGCTGGATGACATCCCTACTGTGCCATGTCCTGGGGCATTTGGAAGGGACTGGACCTCTTTC
 881 CCCTCATCAAAGGAAACAGCAGTCTTTGCCTCTTTCTGTTGGTTGTGCCCAAGGGCTACAGTAGCTCTGAAATAACAAGA
 961 GCTCTGTAATAACAGTAATAAATAGCTCTGAAATAACAGTCCTAAGAACTCCTAAAGTCCTGAGAACTTTTCTTGTAATG
1041 CAGCTTTTTCTCTTCCTGAGAAACAGTGTGTTCTAATGGGATTCCCAGGCAGTTCCTACACCTACGGTGTGTGTTCCAGC
1121 AGGGAGGAGTTATGGGCTGGGCTGCCTTTTCCCATGGGTCTTCATTCCCAATGGAAAGTTCACTCTGCTTAGTTTGGAAT
1201 TATTTTTCTTTCAGTTGTTCTGGAACCTTTGCTTTTTATTGATTTATACAATACAATTGGTGGGAGGGTGGACTTGGGAT
1281 GGGAGTGGGAAAAGCATGTAAGAGCTCCTTTTGTGATGGTCCATCTACCCAAAAGAGATCTGCTTTAGTGAACGATACTC
1361 TTTCATTTTTCTAAATTAGATCAAGTTGTTATTGATTTTAGATGACTTGTATGCAAATTTGAAAAACTTTTTTTTTTAAA
1441 GCTGATTGGGAACTACAAACAATGAATGGAATCTACTGACACAGCTAATTGGAAAACAGATGTCTTCTTCTGTCCTATTG
1521 ATGCTGGTGTTTAAAAAACATCACTTAAAAAAAAAGAATAAATAGTTCTAAAAGCAAGAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUCCGUCCAAGGACCUAGUa 5'
            |||||||    ||||||| 
Target 5' tgAGGCAGG----TGGATCAc 3'
 450 - 466 161.00 -21.80
2 
miRNA  3' ucUCCGUCCAAGGACCUAGUa 5'
            |||||| |  ||||:| | 
Target 5' gcAGGCAGCT--CTGGGTGAg 3'
 26 - 44 119.00 -17.10
3 
miRNA  3' ucUCCGUC---CAAGG--ACCUAGua 5'
            :||| |    ||||  |||:||  
Target 5' ctGGGCTGCCTTTTCCCATGGGTCtt 3'
 1137 - 1162 117.00 -12.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20160371 36 COSMIC
COSN30475387 38 COSMIC
COSN30155046 44 COSMIC
COSN30486466 46 COSMIC
COSN29420721 52 COSMIC
COSN30511341 63 COSMIC
COSN5945202 100 COSMIC
COSN27879444 172 COSMIC
COSN28878559 180 COSMIC
COSN9562144 212 COSMIC
COSN19555658 292 COSMIC
COSN20109532 1063 COSMIC
COSN7372564 1075 COSMIC
COSN31960781 1220 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs755367848 1 dbSNP
rs193291630 2 dbSNP
rs368154611 3 dbSNP
rs1329354767 8 dbSNP
rs1283739782 11 dbSNP
rs753436252 11 dbSNP
rs902323657 12 dbSNP
rs756281463 15 dbSNP
rs201684982 16 dbSNP
rs375294314 17 dbSNP
rs750471389 23 dbSNP
rs767571264 24 dbSNP
rs1416121499 25 dbSNP
rs1156887170 42 dbSNP
rs1470111563 45 dbSNP
rs200565338 46 dbSNP
rs1180924762 50 dbSNP
rs534362590 54 dbSNP
rs1235968750 59 dbSNP
rs574949674 73 dbSNP
rs554603368 81 dbSNP
rs537589538 82 dbSNP
rs1055090187 84 dbSNP
rs1170108238 85 dbSNP
rs939329935 85 dbSNP
rs1465377560 96 dbSNP
rs1169059800 102 dbSNP
rs535213432 116 dbSNP
rs1415295707 117 dbSNP
rs1333563424 126 dbSNP
rs1338723334 131 dbSNP
rs1433012767 135 dbSNP
rs1279938756 136 dbSNP
rs996800689 146 dbSNP
rs1217785670 151 dbSNP
rs551788574 152 dbSNP
rs78730237 156 dbSNP
rs1200631054 157 dbSNP
rs1277516791 160 dbSNP
rs1440131116 166 dbSNP
rs1168424091 171 dbSNP
rs1264512591 172 dbSNP
rs1465538014 173 dbSNP
rs1375876223 174 dbSNP
rs1173988615 175 dbSNP
rs1481470067 176 dbSNP
rs1430215187 178 dbSNP
rs1181775741 179 dbSNP
rs1477818661 182 dbSNP
rs999104685 189 dbSNP
rs749121599 190 dbSNP
rs1482275321 193 dbSNP
rs1254486431 206 dbSNP
rs1466893231 211 dbSNP
rs779772518 215 dbSNP
rs920750040 234 dbSNP
rs1042809403 235 dbSNP
rs1402460090 235 dbSNP
rs973993715 241 dbSNP
rs1361056270 244 dbSNP
rs1399385630 249 dbSNP
rs1196758570 251 dbSNP
rs1332565960 253 dbSNP
rs1483171050 257 dbSNP
rs79022152 267 dbSNP
rs910967719 269 dbSNP
rs756045310 270 dbSNP
rs1323689388 275 dbSNP
rs1218157126 285 dbSNP
rs546502756 289 dbSNP
rs189053415 290 dbSNP
rs1488237237 309 dbSNP
rs1215020702 311 dbSNP
rs567355915 314 dbSNP
rs1055384927 323 dbSNP
rs1226268469 323 dbSNP
rs184347222 326 dbSNP
rs781523721 327 dbSNP
rs977954027 334 dbSNP
rs867438685 340 dbSNP
rs1471304496 350 dbSNP
rs1395247493 352 dbSNP
rs1399914774 353 dbSNP
rs1304561061 358 dbSNP
rs1022094046 359 dbSNP
rs192182100 361 dbSNP
rs1011159100 369 dbSNP
rs1387124556 369 dbSNP
rs562886912 370 dbSNP
rs1322725347 371 dbSNP
rs1328963650 373 dbSNP
rs12422786 388 dbSNP
rs895017626 394 dbSNP
rs546247964 401 dbSNP
rs532572583 408 dbSNP
rs1471700201 411 dbSNP
rs560733496 414 dbSNP
rs1237325448 422 dbSNP
rs1003659737 423 dbSNP
rs200308133 436 dbSNP
rs1209587828 443 dbSNP
rs756784979 448 dbSNP
rs1459390752 449 dbSNP
rs751102654 456 dbSNP
rs1254661540 462 dbSNP
rs1202747905 477 dbSNP
rs1028368921 482 dbSNP
rs1370112274 488 dbSNP
rs1458381662 513 dbSNP
rs1162410254 514 dbSNP
rs1267005639 518 dbSNP
rs975416613 520 dbSNP
rs1206302733 523 dbSNP
rs1330696212 524 dbSNP
rs763818205 549 dbSNP
rs574972659 557 dbSNP
rs1019964286 558 dbSNP
rs998762218 562 dbSNP
rs1443916205 573 dbSNP
rs1190095778 580 dbSNP
rs1243763363 587 dbSNP
rs1322829157 600 dbSNP
rs1244641854 606 dbSNP
rs967643508 613 dbSNP
rs866944795 622 dbSNP
rs1199677935 639 dbSNP
rs568775711 640 dbSNP
rs550523606 641 dbSNP
rs575270024 642 dbSNP
rs1037836770 646 dbSNP
rs1055436441 648 dbSNP
rs1002965311 650 dbSNP
rs535414183 654 dbSNP
rs1455739052 661 dbSNP
rs1387353894 663 dbSNP
rs1159416210 666 dbSNP
rs906843825 667 dbSNP
rs910756273 669 dbSNP
rs1457694772 672 dbSNP
rs1047111424 673 dbSNP
rs1161257319 682 dbSNP
rs1457037296 683 dbSNP
rs1394956042 684 dbSNP
rs1491299112 684 dbSNP
rs1491379359 685 dbSNP
rs1219631713 688 dbSNP
rs1445709233 688 dbSNP
rs1247959547 690 dbSNP
rs940274223 690 dbSNP
rs1186083933 692 dbSNP
rs1316267876 694 dbSNP
rs985155961 694 dbSNP
rs1212448070 695 dbSNP
rs908744842 695 dbSNP
rs1198810468 696 dbSNP
rs1255299683 697 dbSNP
rs558250550 697 dbSNP
rs1194092162 698 dbSNP
rs1319093719 698 dbSNP
rs1426556948 699 dbSNP
rs931432773 699 dbSNP
rs1359396389 700 dbSNP
rs1465096328 700 dbSNP
rs1208936883 701 dbSNP
rs1362974603 702 dbSNP
rs1401195776 702 dbSNP
rs1278144410 703 dbSNP
rs933758642 703 dbSNP
rs1266928342 704 dbSNP
rs1302168547 704 dbSNP
rs1288296519 707 dbSNP
rs1491372232 707 dbSNP
rs1192763812 708 dbSNP
rs1217201790 708 dbSNP
rs1262396431 708 dbSNP
rs1285479231 708 dbSNP
rs1484740016 708 dbSNP
rs1488672360 708 dbSNP
rs1491195595 708 dbSNP
rs34031535 708 dbSNP
rs371815045 708 dbSNP
rs752572602 708 dbSNP
rs755676041 708 dbSNP
rs1311783230 709 dbSNP
rs1491159030 709 dbSNP
rs1354425379 710 dbSNP
rs1364321449 710 dbSNP
rs1239539443 717 dbSNP
rs1295346092 727 dbSNP
rs1223458925 733 dbSNP
rs12310813 734 dbSNP
rs1239623656 743 dbSNP
rs1439711953 746 dbSNP
rs1328320358 747 dbSNP
rs975496765 757 dbSNP
rs1386484102 759 dbSNP
rs978167141 761 dbSNP
rs966613244 765 dbSNP
rs566137091 777 dbSNP
rs1022631539 785 dbSNP
rs1333549610 789 dbSNP
rs965779549 798 dbSNP
rs367894783 800 dbSNP
rs1425726830 801 dbSNP
rs12297470 802 dbSNP
rs1167303986 803 dbSNP
rs1476104798 805 dbSNP
rs773876314 816 dbSNP
rs1320821186 828 dbSNP
rs967315478 834 dbSNP
rs1197564380 836 dbSNP
rs1033537701 845 dbSNP
rs1449447731 847 dbSNP
rs1021457761 848 dbSNP
rs11608670 849 dbSNP
rs77552223 852 dbSNP
rs1457984850 858 dbSNP
rs80343014 883 dbSNP
rs76181949 897 dbSNP
rs78426667 897 dbSNP
rs993911582 897 dbSNP
rs1413725339 904 dbSNP
rs1034080269 968 dbSNP
rs763962393 972 dbSNP
rs1341259189 983 dbSNP
rs1173362240 993 dbSNP
rs1401263648 998 dbSNP
rs899205880 1004 dbSNP
rs112481549 1014 dbSNP
rs1327131619 1014 dbSNP
rs1038353227 1027 dbSNP
rs1002609055 1030 dbSNP
rs550538854 1038 dbSNP
rs774381502 1051 dbSNP
rs1231218749 1053 dbSNP
rs74089127 1055 dbSNP
rs1318136162 1061 dbSNP
rs1435857141 1064 dbSNP
rs768910373 1065 dbSNP
rs147664899 1066 dbSNP
rs1210285707 1067 dbSNP
rs1237411320 1067 dbSNP
rs1474536073 1069 dbSNP
rs74089125 1081 dbSNP
rs1424728709 1088 dbSNP
rs922356754 1095 dbSNP
rs1042177573 1096 dbSNP
rs1370401360 1101 dbSNP
rs371060675 1105 dbSNP
rs931485128 1106 dbSNP
rs775327314 1111 dbSNP
rs1280039297 1113 dbSNP
rs1040219347 1115 dbSNP
rs989786270 1129 dbSNP
rs944125945 1133 dbSNP
rs1346772701 1136 dbSNP
rs138484381 1140 dbSNP
rs1279053554 1155 dbSNP
rs368960428 1171 dbSNP
rs912591564 1175 dbSNP
rs1219384743 1178 dbSNP
rs560518357 1195 dbSNP
rs540918422 1197 dbSNP
rs1482604528 1203 dbSNP
rs187052421 1217 dbSNP
rs1191558775 1221 dbSNP
rs563551739 1225 dbSNP
rs759248275 1227 dbSNP
rs914502267 1231 dbSNP
rs1393292737 1232 dbSNP
rs1421624884 1256 dbSNP
rs1299899893 1258 dbSNP
rs1361155262 1265 dbSNP
rs769630435 1266 dbSNP
rs990001452 1270 dbSNP
rs1332445854 1277 dbSNP
rs1438261150 1278 dbSNP
rs958554978 1285 dbSNP
rs1302279422 1296 dbSNP
rs1218676217 1297 dbSNP
rs1321553921 1306 dbSNP
rs1285422691 1307 dbSNP
rs1224412254 1309 dbSNP
rs1350666580 1323 dbSNP
rs1350114047 1328 dbSNP
rs1269975288 1331 dbSNP
rs551207037 1332 dbSNP
rs544449366 1337 dbSNP
rs1251388933 1339 dbSNP
rs981632779 1346 dbSNP
rs1444852788 1352 dbSNP
rs55965727 1353 dbSNP
rs147534243 1354 dbSNP
rs1453034900 1356 dbSNP
rs1156768838 1360 dbSNP
rs1392572659 1362 dbSNP
rs1387143588 1363 dbSNP
rs1008194826 1367 dbSNP
rs889372009 1374 dbSNP
rs1004562091 1379 dbSNP
rs183370053 1380 dbSNP
rs1309398031 1381 dbSNP
rs1407747628 1389 dbSNP
rs1237452788 1392 dbSNP
rs8804 1392 dbSNP
rs141601309 1416 dbSNP
rs1027261477 1418 dbSNP
rs995742793 1426 dbSNP
rs1042517673 1433 dbSNP
rs900033236 1437 dbSNP
rs1053470729 1438 dbSNP
rs1179312482 1438 dbSNP
rs914869590 1438 dbSNP
rs1249850863 1443 dbSNP
rs1039868564 1444 dbSNP
rs1417441630 1445 dbSNP
rs1179490980 1449 dbSNP
rs1345421324 1451 dbSNP
rs1458206183 1453 dbSNP
rs781143019 1457 dbSNP
rs1391788590 1458 dbSNP
rs1236814532 1459 dbSNP
rs1208012948 1463 dbSNP
rs1331640503 1463 dbSNP
rs756695614 1466 dbSNP
rs1265017449 1470 dbSNP
rs536532792 1473 dbSNP
rs1204387672 1475 dbSNP
rs751534287 1484 dbSNP
rs926530151 1485 dbSNP
rs1233024770 1488 dbSNP
rs1328700766 1497 dbSNP
rs1291876346 1502 dbSNP
rs982066789 1505 dbSNP
rs1250976972 1512 dbSNP
rs763099417 1512 dbSNP
rs891218430 1514 dbSNP
rs1202305160 1515 dbSNP
rs1042164089 1517 dbSNP
rs946069391 1526 dbSNP
rs914556234 1527 dbSNP
rs1374560886 1535 dbSNP
rs919128408 1541 dbSNP
rs990055259 1549 dbSNP
rs1415331202 1550 dbSNP
rs1170863394 1556 dbSNP
rs1478698247 1556 dbSNP
rs963504719 1556 dbSNP
rs937251833 1564 dbSNP
rs567479244 1568 dbSNP
rs1304120825 1577 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucUCCGUCCAAGGACCUAgua 5'
            |||||||    |||||   
Target 5' ugAGGCAGG----UGGAU--- 3'
 		18 - 31
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_024095 | 3UTR | UGGCUCACGUCUGUAAUCCCAGGACUUUGGGAGGCUGAGGCAGGUGGAUCACCUGAGGUCAGGAGUUCGAGCCCAGCCUGACCAAUAUGAUGAAACCCCGUCUCUACUAAAAAUACAAAAAUUAGCUGGGCAUGGUGGCAUGCGCCUGUAAUCCCAGCUACUCAGGAGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_024095 | 3UTR | GAGGCAGGUGGAUCACCUGAGGUCAGGAGUUCGAGCCCAGCCUGACCAAUAUGAUGAAACCCCGUCUCUACUAAAAAUACAAAAAUUAGCUGGGCAUGGUGGCAUGCGCCUGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_024095 | 3UTR | UAAUCCCAGGACUUUGGGAGGCUGAGGCAGGUGGAUCACCUGAGGUCAGGAGUUCGAGCCCAGCCUGACCAAUAUGAUGAAACCCCGUCUCUACUAAAAAUACAAAAAUUAGCUGGGCAUGGUGGCAUGCGCCUGUAAUCCCAGCUACUCAGGAGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_024095 | 3UTR | GCCAUGGUGGCUCACGUCUGUAAUCCCAGGACUUUGGGAGGCUGAGGCAGGUGGAUCACCUGAGGUCAGGAGUUCGAGCCCAGCCUGACCAAUAUGAUGAAACCCCGUCUCUACUAAAAAUACAAAAAUUAGCUGGGCAUGGUGGCAUGCGCCUGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_024095 | 3UTR | GGACUUUGGGAGGCUGAGGCAGGUGGAUCACCUGAGGUCAGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000317697.3 | 3UTR | CCAGGACUUUGGGAGGCUGAGGCAGGUGGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.901 1.3e-5 0.872 5.1e-5 13 Click to see details
GSE28544 Breast cancer 0.645 3.3e-4 0.544 3.0e-3 24 Click to see details
GSE21687 Ependynoma primary tumors -0.262 1.8e-2 -0.175 8.3e-2 64 Click to see details
GSE19350 CNS germ cell tumors -0.605 1.9e-2 0.000 5.0e-1 12 Click to see details
GSE19783 ER- ER- breast cancer -0.208 3.3e-2 -0.161 7.8e-2 79 Click to see details
GSE19536 Breast cancer -0.149 6.9e-2 -0.109 1.4e-1 100 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.253 1.1e-1 -0.163 2.2e-1 25 Click to see details
GSE27834 Pluripotent stem cells -0.306 1.2e-1 -0.344 9.6e-2 16 Click to see details
GSE14794 Lymphoblastoid cells 0.111 1.5e-1 0.149 8.1e-2 90 Click to see details
GSE17498 Multiple myeloma -0.161 1.6e-1 -0.114 2.4e-1 40 Click to see details
GSE21849 B cell lymphoma 0.16 2.0e-1 0.309 5.1e-2 29 Click to see details
GSE32688 Pancreatic cancer -0.138 2.3e-1 -0.144 2.2e-1 32 Click to see details
GSE19783 ER+ ER+ breast cancer -0.122 3.0e-1 -0.101 3.4e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.122 3.0e-1 -0.048 4.2e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells -0.055 4.0e-1 0.021 4.6e-1 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.055 4.0e-1 0.000 5.0e-1 23 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.05 4.1e-1 0.060 3.9e-1 25 Click to see details
GSE17306 Multiple myeloma 0.029 4.2e-1 0.187 9.9e-2 49 Click to see details
GSE38226 Liver fibrosis -0.021 4.6e-1 -0.115 3.1e-1 21 Click to see details
GSE38226 Liver fibrosis -0.021 4.6e-1 -0.115 3.1e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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