pre-miRNA Information
pre-miRNA hsa-mir-4708   
Genomic Coordinates chr14: 65335117 - 65335183
Description Homo sapiens miR-4708 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4708-5p
Sequence 9| AGAGAUGCCGCCUUGCUCCUU |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1017378847 9 dbSNP
rs750825813 10 dbSNP
rs1297395738 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FRMD8   
Synonyms FKSG44
Description FERM domain containing 8
Transcript NM_031904   
Expression
Putative miRNA Targets on FRMD8
3'UTR of FRMD8
(miRNA target sites are highlighted)
>FRMD8|NM_031904|3'UTR
   1 GGACGCTGCACCCGGCAGGAGGAGGGCGACTGGGGGCCCTGGCCCGGCACTGTCCTCCTGAGGGGCAGGCGCCGGCTGCA
  81 ACAGTCTCATGGGTCACCACGTGGGGAGGGCTGCCTCAGCAGGTTTCTCAGACCACGGAGAAGTGACTTTTGGGCCCGGG
 161 GCCATGCCCGGGCTGTGCAAAGCTGGCCAGGGCCTCCTGTAGGGCTCCTCTGCAGCCTGCCCTGCCTTCCCCCGGATGCT
 241 GGGCCCTGCTGCTCTCTCAGGACCATCCGATCAAGCTGCAGCTGCCACCCTCACCTAGAAACATGCCTTTGTGCCCACCT
 321 CAAGATGGGCAGTGTCCCTGTTCTGAAGTGCCCAGTGGCAGCTCCAGTGGTAGAGGACCAAGGATTGAGGTTTGGGACCT
 401 GAAGCTCCAGTGTGTGCCTTTGGCCTCTTCCCTGGACTTGGGTGACCAGTCTCCGTCTTCCTCCTGCTAGTGCTCCACCC
 481 CCCGGACTTGGATGACCAGTTTCCCACCTTCCTCCTGCTGGTGCTCCATCCCCCAATACCAGGCTGGGCCACCACTCTGA
 561 GGAGGGTAGGAGGGGCCTCCCTGGATTGAACCGGGACAGAAACACGGTGAGGGCCCCCACCACACCTCCCTGGTTGAATC
 641 AGGAATGGAGGGAGCCAGGCAGGGCCCTACCTGGGGTCCTGTGCCCCTCGTTCTGGTCTCCTTTGCAGGCACGAGATACC
 721 AGAAAGAGCATGCCTTTCTGATAGCCTTTGGTGATGTCACTGCTGGGAGGTGGCTATCCTGTGGACCACCTGGCCTCCAG
 801 ACCCACACTCACAGTCTGTGAAAAACTGAAAATCCCCTGGTGGGCACTCCCTGGAGCCCAAGCAGCTCCCCTAGGGGACT
 881 GACCGGACCTGACCTCCCCTCCCTGTGTCTGGGTCTTCAGGTTTTAGTTTGGTCTTTGTTCATCTGAGTTGTGCTGGGGC
 961 AACGCCAGGAAGTGCCCTGGGTAACCTCTGCTGTGCGCTCCTTCCCAGGTGGCGCCATGGATTCCTCTGGGGGCTGGCGC
1041 ATGCCCAGGAAAGCCTGGGCCACACGGGACACTCTCTTCTTTATCGAGGACACTTGGAAAGGTGACTGATATGGGTGCTT
1121 GGCTTCTCTGGTCCCAGCTTGCCCTCCGGGGAGCAGGGGCTCTGTCTTGTCCCAGATGAGCTGAGAGCCCCTGAGAGGAG
1201 GGCTTTCCCAGCCCTGGGACCCTCCGAGGTGGGTGTGCGGGTCTCACAGGTGCTTCCTGGGACTTCCTGTGGCTGCACAG
1281 GGCTTGGCTTTGTCTTCGTTCCCGGTGGAAAACCGTGGGAGAGGAAGCTTGGGCCTCTACTCCAAGTATCAGAGCCTGTT
1361 CACCCTCCTCCCTTTGGTAGCTTGTGAATGTGCCAGGTGTTTCGAGGTAGGCTTGCCTTCTGGCAGCATGGACTTTGTTA
1441 AAATAATAGGCGGAAAGAAGAGGCCTGGGAAGGGCCCCCAGTCTTTTGGAATGTCCTGGTCACAGGGTCATGTCAGCTGC
1521 CAGTTCTCGTCTCCCGTCCTGGAGTTGCTCGGTCTTGCGGAGCTGCCCGCCTGCCTGTTCTGGCGGCTCCAGCGCAGGCT
1601 GTCCCTGCTGCTTTGATTCCAGGTGATTTTATTTTTTTTATTTTTTTATTTTTTTTGAGACGGAGTCTTGCTCTGTTGCC
1681 CAGGCAGGAGTGCAGTGGCGCATCTCGGCTCACTGCAACCTCTGTCTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAG
1761 CTGGGATTACAGGTGCATGCCACCAGGCCCCGCTGATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAG
1841 GCTGGTCGTGAACTCCTGACCTCATGATCTGCCCGCCTCAACCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCC
1921 CCCAGCTGATTCCAGGCGAATTCTTCTCTGATGGGCGGGCGAGGGTGTGTTCGTGTGATGGGTTGGAGTGTGTGTGTCTG
2001 AGTACACAGATGATGTGTTTTCCCTTCAGCTTCTTACGTTTTCTGAGCATCCGTTGTGCCTTAACATTTTCTGCTTGTCC
2081 TTTGGGACAAAGCAGTATTTTACTCATTCTTTGAATGTTCTCATTCTTTTGTATCATGTGACTTATTAAAATCAGTTTCT
2161 AACAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuCCU--CGUU-CCGCCGUAGAGa 5'
            |||  |||: ||| ||||||| 
Target 5' caGGAGTGCAGTGGC-GCATCTCg 3'
1685 - 1707 160.00 -21.50
2
miRNA  3' uucCUCGUUCCGCCGUAGAGa 5'
             | ||   |:|||| ||| 
Target 5' gaaGTGCCCAGTGGCAGCTCc 3'
345 - 365 122.00 -13.10
3
miRNA  3' uuCCUC--GUUCCGCCGUAGAGa 5'
            ||||  |||    ||| ||| 
Target 5' ctGGAGCCCAA----GCAGCTCc 3'
851 - 869 119.00 -10.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM6417823 1 COSMIC
COSN30117292 5 COSMIC
COSN31537316 46 COSMIC
COSN7017037 483 COSMIC
COSN1540840 543 COSMIC
COSN7017038 593 COSMIC
COSN15059982 809 COSMIC
COSN26775678 821 COSMIC
COSN20108389 984 COSMIC
COSN31959557 1047 COSMIC
COSN7017040 1891 COSMIC
COSN20697066 2041 COSMIC
COSN22920865 2146 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1411813265 2 dbSNP
rs368804171 4 dbSNP
rs371227340 5 dbSNP
rs375005253 6 dbSNP
rs1465778046 8 dbSNP
rs751455518 12 dbSNP
rs1370942639 13 dbSNP
rs761741280 14 dbSNP
rs1306129298 15 dbSNP
rs1349850287 17 dbSNP
rs1219736794 22 dbSNP
rs932780311 24 dbSNP
rs766973467 28 dbSNP
rs1178822360 29 dbSNP
rs747454190 29 dbSNP
rs562439563 31 dbSNP
rs1232085052 32 dbSNP
rs1274866110 33 dbSNP
rs1050162763 34 dbSNP
rs1484255830 35 dbSNP
rs199504802 37 dbSNP
rs755742529 38 dbSNP
rs1451414195 40 dbSNP
rs1489129741 41 dbSNP
rs779796848 43 dbSNP
rs776897745 46 dbSNP
rs755429880 47 dbSNP
rs1482781118 48 dbSNP
rs190589959 50 dbSNP
rs571223712 51 dbSNP
rs748602856 52 dbSNP
rs777648527 53 dbSNP
rs537468013 65 dbSNP
rs768961997 71 dbSNP
rs1291261767 72 dbSNP
rs115568162 74 dbSNP
rs1211943130 75 dbSNP
rs1057013957 83 dbSNP
rs1437679232 88 dbSNP
rs1379501807 100 dbSNP
rs567285199 101 dbSNP
rs536039335 102 dbSNP
rs577119214 104 dbSNP
rs562143064 106 dbSNP
rs1431651924 107 dbSNP
rs556045264 109 dbSNP
rs1023012765 111 dbSNP
rs888125912 111 dbSNP
rs1424594202 120 dbSNP
rs1416303891 121 dbSNP
rs1183375621 124 dbSNP
rs1005208035 128 dbSNP
rs115980420 137 dbSNP
rs1162387312 138 dbSNP
rs1366293949 139 dbSNP
rs961645883 144 dbSNP
rs1263134973 146 dbSNP
rs1459112572 147 dbSNP
rs1220259231 148 dbSNP
rs1321940811 152 dbSNP
rs1314431850 153 dbSNP
rs538547183 158 dbSNP
rs1395467955 159 dbSNP
rs557821801 162 dbSNP
rs577987983 166 dbSNP
rs1029793371 168 dbSNP
rs774897464 170 dbSNP
rs540302490 171 dbSNP
rs946724593 181 dbSNP
rs1455403246 182 dbSNP
rs1411003021 190 dbSNP
rs1182685708 198 dbSNP
rs554215392 199 dbSNP
rs573842825 206 dbSNP
rs1338834528 208 dbSNP
rs3802944 209 dbSNP
rs562349477 213 dbSNP
rs1266794850 216 dbSNP
rs1266299422 218 dbSNP
rs1339110245 220 dbSNP
rs1197183170 221 dbSNP
rs1269137000 222 dbSNP
rs2957273 225 dbSNP
rs1458619195 227 dbSNP
rs895671452 234 dbSNP
rs183050978 235 dbSNP
rs1253460001 237 dbSNP
rs1044141289 238 dbSNP
rs1369853876 243 dbSNP
rs888217288 246 dbSNP
rs1434611309 252 dbSNP
rs1389728379 253 dbSNP
rs1372169267 269 dbSNP
rs564689704 270 dbSNP
rs1175294959 286 dbSNP
rs1015248081 290 dbSNP
rs1268800942 291 dbSNP
rs1186177918 318 dbSNP
rs897379406 319 dbSNP
rs1248332531 330 dbSNP
rs998395303 331 dbSNP
rs1343330512 332 dbSNP
rs1255875307 337 dbSNP
rs768169766 339 dbSNP
rs1400868903 344 dbSNP
rs1314510610 351 dbSNP
rs1295470071 360 dbSNP
rs1227848124 366 dbSNP
rs527265651 368 dbSNP
rs371940201 369 dbSNP
rs986059529 372 dbSNP
rs1399836374 386 dbSNP
rs1022359012 393 dbSNP
rs760846794 399 dbSNP
rs867354713 408 dbSNP
rs968162989 411 dbSNP
rs1282487952 418 dbSNP
rs1166170860 419 dbSNP
rs1448354906 422 dbSNP
rs978077614 428 dbSNP
rs1194907717 449 dbSNP
rs1441014293 453 dbSNP
rs1255872997 454 dbSNP
rs1400113927 455 dbSNP
rs1397908950 456 dbSNP
rs1273110839 467 dbSNP
rs1227681430 469 dbSNP
rs1342986258 470 dbSNP
rs187158856 474 dbSNP
rs867658487 479 dbSNP
rs1326081393 483 dbSNP
rs560965068 484 dbSNP
rs1280481028 485 dbSNP
rs1319120718 494 dbSNP
rs1203556074 507 dbSNP
rs529859197 508 dbSNP
rs917184959 513 dbSNP
rs1370673570 515 dbSNP
rs1169190475 522 dbSNP
rs1254812551 533 dbSNP
rs948564605 535 dbSNP
rs1483919833 541 dbSNP
rs1044661014 553 dbSNP
rs775364948 557 dbSNP
rs754072434 560 dbSNP
rs754786827 571 dbSNP
rs79588035 586 dbSNP
rs941123185 593 dbSNP
rs1036616752 594 dbSNP
rs998364092 603 dbSNP
rs1266268818 604 dbSNP
rs3741389 606 dbSNP
rs890056490 606 dbSNP
rs1007054943 607 dbSNP
rs1351089069 612 dbSNP
rs1330298475 621 dbSNP
rs1424066148 625 dbSNP
rs1022918015 630 dbSNP
rs1163501198 644 dbSNP
rs1463302633 657 dbSNP
rs1480008692 662 dbSNP
rs1173840385 665 dbSNP
rs538513195 668 dbSNP
rs1181969497 670 dbSNP
rs1473197183 681 dbSNP
rs968088640 682 dbSNP
rs1451123846 685 dbSNP
rs552067586 690 dbSNP
rs191184616 691 dbSNP
rs1303514833 696 dbSNP
rs1227625139 697 dbSNP
rs1360048248 701 dbSNP
rs960685164 705 dbSNP
rs758287180 713 dbSNP
rs764080255 714 dbSNP
rs534194182 723 dbSNP
rs1330030322 735 dbSNP
rs1323687090 743 dbSNP
rs1300327326 746 dbSNP
rs1471026257 752 dbSNP
rs1386073053 755 dbSNP
rs917172626 756 dbSNP
rs970414350 771 dbSNP
rs979926129 782 dbSNP
rs1171363280 787 dbSNP
rs1477716722 791 dbSNP
rs1247333829 796 dbSNP
rs1195633975 804 dbSNP
rs1463706184 805 dbSNP
rs1341497776 806 dbSNP
rs1207811360 815 dbSNP
rs1447384182 816 dbSNP
rs1286207964 819 dbSNP
rs1217371709 826 dbSNP
rs553919291 838 dbSNP
rs1303485723 845 dbSNP
rs1235943757 847 dbSNP
rs1362494976 851 dbSNP
rs1319484978 853 dbSNP
rs573753538 857 dbSNP
rs138112752 867 dbSNP
rs1347350274 874 dbSNP
rs941090642 878 dbSNP
rs56308560 883 dbSNP
rs1036753815 884 dbSNP
rs918363434 885 dbSNP
rs182965468 886 dbSNP
rs187423544 897 dbSNP
rs544911458 899 dbSNP
rs1189486409 921 dbSNP
rs1051239818 931 dbSNP
rs890034651 933 dbSNP
rs746746084 935 dbSNP
rs1487060534 937 dbSNP
rs1207827609 949 dbSNP
rs1280957250 952 dbSNP
rs1212332572 957 dbSNP
rs149455122 960 dbSNP
rs1263511503 964 dbSNP
rs1043858526 965 dbSNP
rs1214765750 967 dbSNP
rs1282779315 968 dbSNP
rs1490110444 968 dbSNP
rs1447851370 972 dbSNP
rs1189278808 981 dbSNP
rs201943275 983 dbSNP
rs34830519 983 dbSNP
rs397731719 983 dbSNP
rs200510134 985 dbSNP
rs1369990120 986 dbSNP
rs904038325 988 dbSNP
rs1158386653 993 dbSNP
rs756773352 996 dbSNP
rs756784636 997 dbSNP
rs1472351027 1000 dbSNP
rs767136209 1007 dbSNP
rs999725747 1009 dbSNP
rs750089274 1011 dbSNP
rs1379738575 1013 dbSNP
rs572299630 1014 dbSNP
rs1273255359 1019 dbSNP
rs960822014 1020 dbSNP
rs780885426 1022 dbSNP
rs755657544 1026 dbSNP
rs541014958 1027 dbSNP
rs1287313752 1029 dbSNP
rs1228052724 1031 dbSNP
rs1356534620 1032 dbSNP
rs1295538825 1034 dbSNP
rs1361447729 1038 dbSNP
rs1350474603 1039 dbSNP
rs1024066015 1050 dbSNP
rs1436124637 1059 dbSNP
rs1463592401 1062 dbSNP
rs1292160397 1066 dbSNP
rs1370248538 1071 dbSNP
rs1387855353 1073 dbSNP
rs560877177 1075 dbSNP
rs1309221544 1076 dbSNP
rs969962046 1077 dbSNP
rs1471562789 1079 dbSNP
rs1350830261 1085 dbSNP
rs1241708329 1086 dbSNP
rs1286234792 1094 dbSNP
rs980445465 1098 dbSNP
rs1244576172 1100 dbSNP
rs1358306131 1108 dbSNP
rs1219006900 1110 dbSNP
rs909689841 1112 dbSNP
rs1488710152 1120 dbSNP
rs1308352602 1141 dbSNP
rs114918863 1147 dbSNP
rs1433352937 1148 dbSNP
rs1293058241 1150 dbSNP
rs34371630 1155 dbSNP
rs972563885 1168 dbSNP
rs1397033176 1171 dbSNP
rs572993689 1185 dbSNP
rs1180593173 1187 dbSNP
rs986446839 1190 dbSNP
rs1422414067 1192 dbSNP
rs1190185757 1203 dbSNP
rs910879639 1208 dbSNP
rs942939524 1209 dbSNP
rs549924935 1214 dbSNP
rs1404970290 1222 dbSNP
rs1163029650 1224 dbSNP
rs1207150772 1225 dbSNP
rs1464746411 1226 dbSNP
rs1261784850 1233 dbSNP
rs1044357936 1235 dbSNP
rs1351951619 1237 dbSNP
rs1458777273 1238 dbSNP
rs1300667624 1239 dbSNP
rs1428591241 1241 dbSNP
rs1331201258 1244 dbSNP
rs1373388969 1248 dbSNP
rs1318802928 1263 dbSNP
rs1375366908 1265 dbSNP
rs563037852 1267 dbSNP
rs1289276749 1268 dbSNP
rs1309339351 1278 dbSNP
rs1375923219 1281 dbSNP
rs1172398492 1283 dbSNP
rs531910205 1294 dbSNP
rs935484899 1296 dbSNP
rs117501472 1297 dbSNP
rs564653793 1298 dbSNP
rs748545503 1299 dbSNP
rs1448541958 1302 dbSNP
rs534233748 1303 dbSNP
rs192221053 1304 dbSNP
rs1255926989 1307 dbSNP
rs772644894 1314 dbSNP
rs905204945 1315 dbSNP
rs1295633496 1327 dbSNP
rs1322049542 1334 dbSNP
rs1327302488 1340 dbSNP
rs1203599205 1341 dbSNP
rs1006250686 1343 dbSNP
rs1399902551 1353 dbSNP
rs1459045924 1356 dbSNP
rs1312220683 1363 dbSNP
rs1434754858 1365 dbSNP
rs1016788169 1367 dbSNP
rs1166228451 1368 dbSNP
rs1461161206 1371 dbSNP
rs1373360150 1372 dbSNP
rs962641157 1391 dbSNP
rs972530856 1396 dbSNP
rs143876962 1403 dbSNP
rs536309985 1404 dbSNP
rs1486965760 1406 dbSNP
rs556221905 1407 dbSNP
rs530493326 1409 dbSNP
rs1371780725 1446 dbSNP
rs1272552549 1447 dbSNP
rs1472532648 1451 dbSNP
rs35999393 1453 dbSNP
rs955109885 1453 dbSNP
rs1253307333 1462 dbSNP
rs1229271121 1463 dbSNP
rs879239900 1472 dbSNP
rs1338516637 1473 dbSNP
rs1416254834 1486 dbSNP
rs986970808 1489 dbSNP
rs1424715896 1492 dbSNP
rs1357353092 1495 dbSNP
rs1305637146 1499 dbSNP
rs1390319058 1510 dbSNP
rs911006055 1511 dbSNP
rs868572451 1514 dbSNP
rs576158286 1521 dbSNP
rs1456679122 1528 dbSNP
rs979133432 1529 dbSNP
rs925518939 1536 dbSNP
rs879746208 1550 dbSNP
rs538826738 1551 dbSNP
rs1438486368 1552 dbSNP
rs558514227 1555 dbSNP
rs1208256436 1559 dbSNP
rs778229645 1566 dbSNP
rs1045542321 1568 dbSNP
rs1233745076 1569 dbSNP
rs1336776296 1577 dbSNP
rs1286397384 1584 dbSNP
rs905299208 1585 dbSNP
rs1384696942 1588 dbSNP
rs1393356058 1591 dbSNP
rs1326914926 1593 dbSNP
rs1463354745 1603 dbSNP
rs1379452613 1605 dbSNP
rs1410332740 1626 dbSNP
rs1158525283 1628 dbSNP
rs1016251470 1631 dbSNP
rs1276051229 1632 dbSNP
rs898381824 1632 dbSNP
rs1196920809 1636 dbSNP
rs12790989 1640 dbSNP
rs12792529 1641 dbSNP
rs1253872978 1647 dbSNP
rs11227186 1648 dbSNP
rs1319811180 1648 dbSNP
rs1469670027 1648 dbSNP
rs12792536 1649 dbSNP
rs1282018475 1661 dbSNP
rs1223117482 1675 dbSNP
rs766425263 1679 dbSNP
rs1277890199 1684 dbSNP
rs1441861173 1691 dbSNP
rs1280777871 1698 dbSNP
rs1230439670 1699 dbSNP
rs1369710304 1702 dbSNP
rs148625495 1706 dbSNP
rs1443512612 1707 dbSNP
rs182811042 1708 dbSNP
rs1025405622 1711 dbSNP
rs1318129977 1712 dbSNP
rs1239359502 1720 dbSNP
rs1387857721 1722 dbSNP
rs1170826589 1724 dbSNP
rs1453887722 1725 dbSNP
rs560840277 1732 dbSNP
rs1395869516 1737 dbSNP
rs1195769253 1742 dbSNP
rs1447936492 1753 dbSNP
rs574501457 1761 dbSNP
rs1447437982 1765 dbSNP
rs1286273325 1773 dbSNP
rs11551353 1774 dbSNP
rs1303555136 1775 dbSNP
rs1236010279 1776 dbSNP
rs563368185 1779 dbSNP
rs1018440411 1781 dbSNP
rs147500819 1783 dbSNP
rs545542504 1784 dbSNP
rs529654768 1788 dbSNP
rs979059620 1791 dbSNP
rs924944626 1792 dbSNP
rs956919674 1796 dbSNP
rs372758636 1798 dbSNP
rs1489441201 1803 dbSNP
rs1171953844 1816 dbSNP
rs1434144503 1818 dbSNP
rs1376116377 1821 dbSNP
rs1425122342 1830 dbSNP
rs1175661290 1834 dbSNP
rs1412204012 1837 dbSNP
rs1419165591 1849 dbSNP
rs1185653962 1854 dbSNP
rs988405470 1856 dbSNP
rs1243734540 1857 dbSNP
rs1185667975 1864 dbSNP
rs1485331304 1874 dbSNP
rs1280402952 1875 dbSNP
rs918203600 1876 dbSNP
rs949565803 1881 dbSNP
rs1045274593 1889 dbSNP
rs1296003237 1890 dbSNP
rs1215474902 1899 dbSNP
rs1342116647 1903 dbSNP
rs1341950946 1906 dbSNP
rs188279937 1907 dbSNP
rs1414687210 1908 dbSNP
rs527955525 1917 dbSNP
rs926692461 1923 dbSNP
rs140067318 1932 dbSNP
rs1274132376 1937 dbSNP
rs567651428 1938 dbSNP
rs1217486408 1940 dbSNP
rs897846499 1942 dbSNP
rs994015070 1945 dbSNP
rs1189430473 1948 dbSNP
rs1479399971 1953 dbSNP
rs529373330 1956 dbSNP
rs530016472 1957 dbSNP
rs192275746 1961 dbSNP
rs1261336392 1973 dbSNP
rs1489452639 1975 dbSNP
rs1336095456 1980 dbSNP
rs1295710209 1987 dbSNP
rs1222116586 1989 dbSNP
rs1194353154 1992 dbSNP
rs145586051 2002 dbSNP
rs1444563519 2013 dbSNP
rs538768445 2022 dbSNP
rs1323641329 2029 dbSNP
rs1174895123 2031 dbSNP
rs61895450 2032 dbSNP
rs1418616205 2033 dbSNP
rs1167064233 2034 dbSNP
rs749416261 2035 dbSNP
rs565759299 2037 dbSNP
rs1177286211 2038 dbSNP
rs1031982673 2050 dbSNP
rs1250819986 2052 dbSNP
rs647284 2053 dbSNP
rs1469225674 2055 dbSNP
rs1400308892 2056 dbSNP
rs1275479464 2059 dbSNP
rs1322664890 2063 dbSNP
rs1316859911 2067 dbSNP
rs184612747 2084 dbSNP
rs1438487207 2088 dbSNP
rs1225605212 2090 dbSNP
rs987828402 2091 dbSNP
rs1303011416 2094 dbSNP
rs1439850718 2097 dbSNP
rs1394893332 2101 dbSNP
rs918160213 2104 dbSNP
rs971036168 2105 dbSNP
rs151116377 2107 dbSNP
rs140031893 2112 dbSNP
rs1441059572 2113 dbSNP
rs1392849636 2114 dbSNP
rs1284066880 2116 dbSNP
rs1356142152 2117 dbSNP
rs942094649 2118 dbSNP
rs1206005898 2126 dbSNP
rs56342407 2126 dbSNP
rs1203760274 2130 dbSNP
rs1289614201 2132 dbSNP
rs1049558306 2151 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuccUCGUUCCGCCGUagaga 5'
              :|||:|   |||     
Target 5' ----GGCAGGAGUGCAguggc 3'
1 - 17
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_031904 | 3UTR | UUUAUUUUUUUUGAGACGGAGUCUUGCUCUGUUGCCCAGGCAGGAGUGCAGUGGCGCAUCUCGGCUCACUGCAACCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_031904 | 3UTR | UUUUUUUAUUUUUUUUGAGACGGAGUCUUGCUCUGUUGCCCAGGCAGGAGUGCAGUGGCGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_031904 | 3UTR | UUAUUUUUUUUGAGACGGAGUCUUGCUCUGUUGCCCAGGCAGGAGUGCAGUGGCGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_031904 | 3UTR | UUAUUUUUUUUGAGACGGAGUCUUGCUCUGUUGCCCAGGCAGGAGUGCAGUGGCGCAUCUCGGCUCACUGCAACCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_031904 | 3UTR | UUUAUUUUUUUUGAGACGGAGUCUUGCUCUGUUGCCCAGGCAGGAGUGCAGUGGCGCAUCUCGGCUCACUGCAACCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000317568.5 | 3UTR | AGGCAGGAGUGCAGUGGCGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000317568.5 | 3UTR | GGCAGGAGUGCAGUGGCGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4708-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT095681 RBM27 RNA binding motif protein 27 2 4
MIRT104033 USP42 ubiquitin specific peptidase 42 2 6
MIRT114773 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT246923 CCND1 cyclin D1 2 2
MIRT392569 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT443949 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT446695 PAPPA pappalysin 1 2 2
MIRT447383 VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2 2
MIRT449321 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT449717 C1orf61 chromosome 1 open reading frame 61 2 2
MIRT449738 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT450531 PGLS 6-phosphogluconolactonase 2 2
MIRT455650 YARS tyrosyl-tRNA synthetase 2 2
MIRT458036 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT463468 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT466677 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 4
MIRT467789 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468167 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT468652 SECISBP2L SECIS binding protein 2 like 2 6
MIRT469380 RER1 retention in endoplasmic reticulum sorting receptor 1 2 2
MIRT470346 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT472418 NCKAP1 NCK associated protein 1 2 2
MIRT474612 KLF3 Kruppel like factor 3 2 2
MIRT478703 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT481008 BBC3 BCL2 binding component 3 2 4
MIRT483098 TFPI tissue factor pathway inhibitor 2 2
MIRT485113 SHISA6 shisa family member 6 2 2
MIRT497533 ZNF607 zinc finger protein 607 2 2
MIRT500644 TUBB2A tubulin beta 2A class IIa 2 6
MIRT500890 STRN striatin 2 4
MIRT501900 MED13 mediator complex subunit 13 2 2
MIRT506646 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT512675 ENO4 enolase family member 4 2 2
MIRT516977 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT528754 RPS27 ribosomal protein S27 2 6
MIRT539670 ZBTB44 zinc finger and BTB domain containing 44 2 2
MIRT544129 PPIL1 peptidylprolyl isomerase like 1 2 2
MIRT546382 STOX2 storkhead box 2 2 4
MIRT562143 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568713 TMEM30B transmembrane protein 30B 2 2
MIRT571029 CENPP centromere protein P 2 2
MIRT572781 ZNF277 zinc finger protein 277 2 2
MIRT573162 SLC30A9 solute carrier family 30 member 9 2 2
MIRT609126 NUDT3 nudix hydrolase 3 2 2
MIRT609284 OAS3 2'-5'-oligoadenylate synthetase 3 2 2
MIRT613430 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613770 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT616645 LRAT lecithin retinol acyltransferase 2 4
MIRT630892 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636526 FAXC failed axon connections homolog 2 4
MIRT641394 NUBPL nucleotide binding protein like 2 2
MIRT641412 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT642528 CERS4 ceramide synthase 4 2 2
MIRT643186 HYPK huntingtin interacting protein K 2 2
MIRT647800 FRMD8 FERM domain containing 8 2 2
MIRT652150 TRIM71 tripartite motif containing 71 2 2
MIRT652602 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT661606 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT666339 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT670414 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671122 ZNF573 zinc finger protein 573 2 2
MIRT671155 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671338 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671869 ZNF429 zinc finger protein 429 2 2
MIRT671974 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672064 KIAA0930 KIAA0930 2 2
MIRT672654 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672673 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672771 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672929 LRRC2 leucine rich repeat containing 2 2 2
MIRT673159 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673272 RUNDC1 RUN domain containing 1 2 2
MIRT673332 THAP1 THAP domain containing 1 2 2
MIRT673351 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673667 ZNF440 zinc finger protein 440 2 2
MIRT673904 DCTN6 dynactin subunit 6 2 2
MIRT674096 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674401 MYCBP MYC binding protein 2 2
MIRT674525 PRR23A proline rich 23A 2 2
MIRT674793 NPR1 natriuretic peptide receptor 1 2 2
MIRT674833 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675066 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675080 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675126 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679401 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT689229 RPS19 ribosomal protein S19 2 2
MIRT694008 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT699671 SFT2D2 SFT2 domain containing 2 2 2
MIRT706213 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706548 GJD2 gap junction protein delta 2 2 2
MIRT707418 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710648 GLUL glutamate-ammonia ligase 2 2
MIRT719393 NPCA1 Nasopharyngeal carcinoma 1 2 2
MIRT720166 PNPO pyridoxamine 5'-phosphate oxidase 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4708-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4708-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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