pre-miRNA Information
pre-miRNA hsa-mir-16-2   
Genomic Coordinates chr3: 160404745 - 160404825
Description Homo sapiens miR-16-2 stem-loop
Comment This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-16-2-3p
Sequence 53| CCAAUAUUACUGUGCUGCUUUA |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30477465 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs746992239 2 dbSNP
rs775368833 4 dbSNP
rs373202341 10 dbSNP
rs768780684 13 dbSNP
rs1341798864 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol BID   
Synonyms FP497
Description BH3 interacting domain death agonist
Transcript NM_001196   
Other Transcripts NM_197966 , NM_197967   
Expression
Putative miRNA Targets on BID
3'UTR of BID
(miRNA target sites are highlighted)
>BID|NM_001196|3'UTR
   1 ACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCC
  81 TGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTAT
 161 AACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGTATTTGAATGGCCTTCATATCATC
 241 CACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAATTAAAT
 321 TGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACC
 401 ATAGAGGATGGTCTTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGA
 481 AAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCAC
 561 AGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTTTTTCAACTTC
 641 GTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACT
 721 GTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAG
 801 CCACGGGTGCCAGAAGCTACTGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATA
 881 CGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAACAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACT
 961 TTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAGGTAGTACCAAAATAAATAAG
1041 GAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAG
1121 CACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGG
1201 AGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAAT
1281 CATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGC
1361 AAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTAC
1441 AAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' auUUCGUCGUGUCA-UUAUAACc 5'
            |||||  ||||| :||: || 
Target 5' aaAAGCACGACAGTGGATGCTGg 3'
1116 - 1138 112.00 -16.30
2
miRNA  3' auuuCGUCGUGUCAUUAUAACc 5'
              || ||||   |||: || 
Target 5' aagtGCTGCACTCAAATGATGg 3'
576 - 597 110.00 -11.70
3
miRNA  3' auUUCGUCGUGUCAUUAUaacc 5'
            |:|:||:||   ||||    
Target 5' ttAGGTAGTACCAAAATAaata 3'
1017 - 1038 104.00 -7.36
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN18717261 2 COSMIC
COSN24293554 40 COSMIC
COSN23529123 46 COSMIC
COSN30155756 57 COSMIC
COSN30529568 65 COSMIC
COSN30529577 90 COSMIC
COSN30124547 112 COSMIC
COSN507126 113 COSMIC
COSN30138662 125 COSMIC
COSN28816985 136 COSMIC
COSN20117130 502 COSMIC
COSN21071796 824 COSMIC
COSN16390267 892 COSMIC
COSN22227295 1125 COSMIC
COSN27039109 1187 COSMIC
COSN15668190 1248 COSMIC
COSN20117129 1268 COSMIC
COSN23477508 1393 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs148682143 2 dbSNP
rs745440984 3 dbSNP
rs1238709610 9 dbSNP
rs1204097546 14 dbSNP
rs780744301 16 dbSNP
rs1312007057 17 dbSNP
rs1484676167 18 dbSNP
rs1243285356 24 dbSNP
rs774410572 27 dbSNP
rs757193291 31 dbSNP
rs1412931410 32 dbSNP
rs8190354 35 dbSNP
rs758207864 36 dbSNP
rs755229729 38 dbSNP
rs368291803 39 dbSNP
rs1362211276 42 dbSNP
rs766770581 46 dbSNP
rs1442956941 49 dbSNP
rs760965422 51 dbSNP
rs372534120 54 dbSNP
rs779513207 59 dbSNP
rs1214973040 66 dbSNP
rs1036458651 67 dbSNP
rs769273022 72 dbSNP
rs566629518 73 dbSNP
rs369074192 74 dbSNP
rs375225896 76 dbSNP
rs1206273105 78 dbSNP
rs1219091354 82 dbSNP
rs1365604246 95 dbSNP
rs1271950245 96 dbSNP
rs1194370282 110 dbSNP
rs928760794 120 dbSNP
rs186394629 122 dbSNP
rs1477164087 123 dbSNP
rs1172152476 130 dbSNP
rs970297485 131 dbSNP
rs1471035037 136 dbSNP
rs2305001 136 dbSNP
rs566764146 139 dbSNP
rs990161187 140 dbSNP
rs1359522995 144 dbSNP
rs1802194 151 dbSNP
rs1320084329 159 dbSNP
rs1329073574 164 dbSNP
rs1061200 166 dbSNP
rs544426630 167 dbSNP
rs565001172 182 dbSNP
rs1431313247 187 dbSNP
rs1275137652 189 dbSNP
rs373153872 204 dbSNP
rs1325243085 205 dbSNP
rs1226089826 207 dbSNP
rs1266880693 209 dbSNP
rs1031696399 213 dbSNP
rs1421063477 215 dbSNP
rs977921585 216 dbSNP
rs1477196403 227 dbSNP
rs544643787 228 dbSNP
rs1260662847 233 dbSNP
rs935414596 236 dbSNP
rs954555499 243 dbSNP
rs1269919581 244 dbSNP
rs923941123 246 dbSNP
rs1481529029 253 dbSNP
rs113283699 262 dbSNP
rs1411279890 266 dbSNP
rs1454253667 267 dbSNP
rs758789061 268 dbSNP
rs996497573 270 dbSNP
rs1388475997 271 dbSNP
rs1386075418 273 dbSNP
rs900383501 274 dbSNP
rs181869684 275 dbSNP
rs1407568698 276 dbSNP
rs952862097 279 dbSNP
rs1329166549 294 dbSNP
rs1240544292 303 dbSNP
rs1027124264 306 dbSNP
rs1269990548 310 dbSNP
rs973104817 310 dbSNP
rs1210052923 311 dbSNP
rs537020099 315 dbSNP
rs540967803 319 dbSNP
rs886218724 320 dbSNP
rs1003613466 321 dbSNP
rs1275688751 327 dbSNP
rs1047526411 331 dbSNP
rs938388909 334 dbSNP
rs907374422 354 dbSNP
rs1276619267 358 dbSNP
rs1012201043 361 dbSNP
rs1044551485 361 dbSNP
rs1307086864 364 dbSNP
rs1373600522 366 dbSNP
rs1392665334 366 dbSNP
rs1339249641 369 dbSNP
rs575412458 369 dbSNP
rs1053636037 378 dbSNP
rs146895750 378 dbSNP
rs201491655 378 dbSNP
rs776421618 379 dbSNP
rs1274278138 380 dbSNP
rs1481066748 381 dbSNP
rs1197684060 383 dbSNP
rs1254119663 385 dbSNP
rs1379638858 386 dbSNP
rs1301995094 390 dbSNP
rs1423174871 393 dbSNP
rs1184061621 396 dbSNP
rs368957466 404 dbSNP
rs1167694500 413 dbSNP
rs1464328804 415 dbSNP
rs544801192 417 dbSNP
rs931584832 421 dbSNP
rs575617011 422 dbSNP
rs1300602118 425 dbSNP
rs1400823373 426 dbSNP
rs1464707835 428 dbSNP
rs559033635 437 dbSNP
rs868546130 448 dbSNP
rs765460407 449 dbSNP
rs920055440 454 dbSNP
rs1226731365 455 dbSNP
rs972884127 460 dbSNP
rs8190355 462 dbSNP
rs1206845788 468 dbSNP
rs990577606 483 dbSNP
rs754320600 490 dbSNP
rs566559199 492 dbSNP
rs1254361922 494 dbSNP
rs1482996740 499 dbSNP
rs934663245 503 dbSNP
rs1423976978 505 dbSNP
rs552836548 506 dbSNP
rs1015088366 507 dbSNP
rs1181682341 508 dbSNP
rs1429961502 509 dbSNP
rs1173456831 513 dbSNP
rs1376692554 513 dbSNP
rs144073937 513 dbSNP
rs8190356 513 dbSNP
rs1338120846 514 dbSNP
rs981909996 530 dbSNP
rs1433450870 534 dbSNP
rs1288691565 539 dbSNP
rs775548793 544 dbSNP
rs1299520951 550 dbSNP
rs569215031 550 dbSNP
rs8190357 550 dbSNP
rs1482470354 551 dbSNP
rs1240638518 564 dbSNP
rs1224266524 567 dbSNP
rs1265021305 568 dbSNP
rs1327001574 568 dbSNP
rs1023318068 572 dbSNP
rs555207372 575 dbSNP
rs986863151 576 dbSNP
rs1317380778 579 dbSNP
rs1266312974 586 dbSNP
rs893728437 587 dbSNP
rs955417854 590 dbSNP
rs767247848 594 dbSNP
rs1409081325 596 dbSNP
rs550824939 597 dbSNP
rs1159083624 604 dbSNP
rs974594453 605 dbSNP
rs1433412212 608 dbSNP
rs759313178 610 dbSNP
rs772178520 611 dbSNP
rs1312251144 613 dbSNP
rs1394131330 629 dbSNP
rs536191527 633 dbSNP
rs1331958629 637 dbSNP
rs1223270693 640 dbSNP
rs567224393 641 dbSNP
rs1016169829 642 dbSNP
rs1166411619 651 dbSNP
rs147656401 656 dbSNP
rs773681981 664 dbSNP
rs1490411629 673 dbSNP
rs1201079203 675 dbSNP
rs1249139702 676 dbSNP
rs878903696 679 dbSNP
rs1469219712 681 dbSNP
rs1008339916 686 dbSNP
rs1409431484 690 dbSNP
rs886125448 695 dbSNP
rs1457945609 699 dbSNP
rs1365298568 710 dbSNP
rs149980557 713 dbSNP
rs1162247304 716 dbSNP
rs573203205 729 dbSNP
rs189629146 733 dbSNP
rs1441648790 734 dbSNP
rs1382487315 747 dbSNP
rs931532156 749 dbSNP
rs1375455412 760 dbSNP
rs1226467224 763 dbSNP
rs1359953238 770 dbSNP
rs1457673261 776 dbSNP
rs553335102 777 dbSNP
rs867495953 779 dbSNP
rs1211762985 786 dbSNP
rs762735083 790 dbSNP
rs1265149038 792 dbSNP
rs536211373 804 dbSNP
rs928849703 805 dbSNP
rs1471460137 814 dbSNP
rs982241307 819 dbSNP
rs948895442 821 dbSNP
rs893405205 823 dbSNP
rs1054725467 824 dbSNP
rs934882557 831 dbSNP
rs924617168 832 dbSNP
rs184390244 837 dbSNP
rs1409542051 841 dbSNP
rs1329625242 842 dbSNP
rs140522332 844 dbSNP
rs957723018 847 dbSNP
rs1032258315 848 dbSNP
rs1383437783 854 dbSNP
rs771123079 854 dbSNP
rs1386908966 855 dbSNP
rs934111724 857 dbSNP
rs1295057467 865 dbSNP
rs966932033 881 dbSNP
rs1389386311 882 dbSNP
rs1274527919 892 dbSNP
rs1291436650 894 dbSNP
rs921345271 895 dbSNP
rs1202448055 907 dbSNP
rs975011040 910 dbSNP
rs964588947 916 dbSNP
rs1382578033 918 dbSNP
rs1159588363 919 dbSNP
rs769682071 922 dbSNP
rs984728163 928 dbSNP
rs1475224401 932 dbSNP
rs1379062108 933 dbSNP
rs889876224 936 dbSNP
rs1433845595 940 dbSNP
rs192534350 946 dbSNP
rs1208306905 948 dbSNP
rs189671157 949 dbSNP
rs8190358 958 dbSNP
rs898528677 960 dbSNP
rs151268390 962 dbSNP
rs1325588871 974 dbSNP
rs867340038 981 dbSNP
rs1022697581 986 dbSNP
rs778069944 987 dbSNP
rs1342429138 1001 dbSNP
rs1276617608 1006 dbSNP
rs1263151107 1010 dbSNP
rs1324889240 1012 dbSNP
rs1206075285 1020 dbSNP
rs1013050560 1024 dbSNP
rs1446830656 1034 dbSNP
rs536450993 1036 dbSNP
rs1330018325 1038 dbSNP
rs928770464 1040 dbSNP
rs1244116092 1053 dbSNP
rs893321111 1068 dbSNP
rs949080684 1073 dbSNP
rs1430027918 1079 dbSNP
rs1360814509 1080 dbSNP
rs768813926 1081 dbSNP
rs1156792804 1087 dbSNP
rs1384122226 1090 dbSNP
rs916322951 1091 dbSNP
rs1419551632 1092 dbSNP
rs561585478 1098 dbSNP
rs990608181 1098 dbSNP
rs1403879070 1100 dbSNP
rs1283398989 1101 dbSNP
rs1174839612 1106 dbSNP
rs879413153 1112 dbSNP
rs771131651 1122 dbSNP
rs544453622 1123 dbSNP
rs999069318 1125 dbSNP
rs903437906 1134 dbSNP
rs924969015 1143 dbSNP
rs1051084004 1149 dbSNP
rs1198909325 1153 dbSNP
rs1269842416 1155 dbSNP
rs933974490 1162 dbSNP
rs115649437 1168 dbSNP
rs1363212123 1172 dbSNP
rs1264248850 1174 dbSNP
rs1454195973 1179 dbSNP
rs779929927 1181 dbSNP
rs1363437415 1187 dbSNP
rs1019832728 1189 dbSNP
rs941403614 1198 dbSNP
rs565216878 1204 dbSNP
rs545522204 1205 dbSNP
rs572896026 1209 dbSNP
rs1305603908 1211 dbSNP
rs878956539 1211 dbSNP
rs1280405730 1213 dbSNP
rs953919817 1219 dbSNP
rs1200988822 1223 dbSNP
rs1028348082 1226 dbSNP
rs552900481 1227 dbSNP
rs1222172972 1233 dbSNP
rs950654122 1235 dbSNP
rs1292864812 1249 dbSNP
rs1490897625 1258 dbSNP
rs1194164041 1262 dbSNP
rs1419629932 1268 dbSNP
rs78336589 1268 dbSNP
rs796069787 1268 dbSNP
rs1183834589 1270 dbSNP
rs25591 1270 dbSNP
rs781640718 1270 dbSNP
rs1340592482 1273 dbSNP
rs1443854099 1273 dbSNP
rs1386724316 1275 dbSNP
rs1004831877 1280 dbSNP
rs919160701 1283 dbSNP
rs1396533005 1286 dbSNP
rs1392604892 1291 dbSNP
rs1334001442 1302 dbSNP
rs1381220735 1304 dbSNP
rs1491190320 1304 dbSNP
rs1491296556 1305 dbSNP
rs981130269 1306 dbSNP
rs1323735317 1308 dbSNP
rs1225462789 1310 dbSNP
rs971062945 1320 dbSNP
rs1023027852 1332 dbSNP
rs879238235 1333 dbSNP
rs745992075 1338 dbSNP
rs1336511197 1339 dbSNP
rs1241266211 1343 dbSNP
rs1460775054 1356 dbSNP
rs1183978299 1367 dbSNP
rs779471037 1376 dbSNP
rs566261700 1383 dbSNP
rs749891086 1387 dbSNP
rs1171327046 1389 dbSNP
rs1373259420 1390 dbSNP
rs1463128160 1393 dbSNP
rs957313208 1393 dbSNP
rs8190360 1394 dbSNP
rs8190361 1395 dbSNP
rs1054867221 1396 dbSNP
rs1476937017 1398 dbSNP
rs1380861923 1400 dbSNP
rs8190362 1401 dbSNP
rs1308289538 1403 dbSNP
rs1051299339 1404 dbSNP
rs1261269551 1405 dbSNP
rs1322779021 1408 dbSNP
rs757744702 1409 dbSNP
rs1244870960 1413 dbSNP
rs1188046813 1418 dbSNP
rs1484795050 1418 dbSNP
rs1262061062 1425 dbSNP
rs1441609863 1425 dbSNP
rs1429864390 1427 dbSNP
rs1196657166 1430 dbSNP
rs924916285 1439 dbSNP
rs557243845 1440 dbSNP
rs754234349 1441 dbSNP
rs1318016244 1443 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000317361.7 | 3UTR | AAAAGAAAGGGAAGAUGGGAUGUGUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer 0.682 8.6e-6 0.359 2.2e-2 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.633 1.4e-3 0.788 1.8e-5 20 Click to see details
GSE28544 Breast cancer -0.512 5.3e-3 -0.644 3.4e-4 24 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.42 1.8e-2 0.383 2.9e-2 25 Click to see details
GSE17498 Multiple myeloma -0.194 1.2e-1 -0.067 3.4e-1 40 Click to see details
GSE19783 ER- ER- breast cancer 0.101 1.9e-1 0.068 2.8e-1 79 Click to see details
GSE21032 Prostate cancer 0.083 2.3e-1 0.028 4.0e-1 83 Click to see details
GSE38226 Liver fibrosis 0.17 2.3e-1 0.116 3.1e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.141 2.5e-1 0.227 1.4e-1 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.125 2.8e-1 -0.181 2.0e-1 23 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.217 2.9e-1 0.333 1.9e-1 9 Click to see details
GSE28260 Renal cortex and medulla -0.171 2.9e-1 -0.137 3.3e-1 13 Click to see details
GSE19350 CNS germ cell tumors -0.144 3.3e-1 -0.091 3.9e-1 12 Click to see details
GSE19783 ER+ ER+ breast cancer -0.085 3.6e-1 -0.377 5.1e-2 20 Click to see details
GSE26953 Aortic valvular endothelial cells -0.055 4.0e-1 0.020 4.6e-1 24 Click to see details
GSE19536 Breast cancer 0.017 4.3e-1 -0.012 4.5e-1 100 Click to see details
GSE21687 Ependynoma primary tumors -0.015 4.5e-1 0.057 3.3e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.648 0 0.652 0 31 Click to see details
ESCA 0.673 0.01 0.755 0 11 Click to see details
BLCA 0.433 0.04 0.375 0.06 18 Click to see details
KIRP 0.32 0.04 0.350 0.02 32 Click to see details
KIRC 0.214 0.04 0.323 0 68 Click to see details
PRAD -0.254 0.04 -0.205 0.08 48 Click to see details
KICH 0.337 0.05 0.260 0.1 25 Click to see details
CHOL -0.506 0.08 -0.433 0.12 9 Click to see details
LUAD 0.375 0.11 0.287 0.18 12 Click to see details
PCPG -0.847 0.18 -0.500 0.33 3 Click to see details
LUSC -0.137 0.21 -0.170 0.15 38 Click to see details
UCEC 0.168 0.25 0.277 0.13 19 Click to see details
PAAD 0.495 0.25 0.800 0.1 4 Click to see details
BRCA -0.059 0.3 -0.044 0.35 83 Click to see details
THCA 0.067 0.31 -0.001 0.5 59 Click to see details
LIHC -0.051 0.36 -0.024 0.43 49 Click to see details
CESC -0.353 0.39 -0.500 0.33 3 Click to see details
HNSC 0.041 0.4 -0.089 0.29 42 Click to see details
HNSC 0.041 0.4 -0.089 0.29 42 Click to see details
HNSC 0.041 0.4 -0.089 0.29 42 Click to see details
75 hsa-miR-16-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004488 RARB retinoic acid receptor beta 3 1
MIRT038707 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 1 1
MIRT057208 PPIF peptidylprolyl isomerase F 2 4
MIRT058726 RSBN1 round spermatid basic protein 1 2 8
MIRT074502 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 4
MIRT081544 ZNF431 zinc finger protein 431 2 4
MIRT096893 ERBB2IP erbb2 interacting protein 2 2
MIRT105124 MYC MYC proto-oncogene, bHLH transcription factor 2 2
MIRT107898 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT109432 KLHL15 kelch like family member 15 2 6
MIRT166742 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 6
MIRT171257 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 2 2
MIRT192760 B2M beta-2-microglobulin 2 2
MIRT194905 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT215599 SUB1 SUB1 homolog, transcriptional regulator 2 2
MIRT223632 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT241605 AMOTL1 angiomotin like 1 2 4
MIRT291174 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT444286 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT463285 ZFX zinc finger protein, X-linked 2 4
MIRT471759 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT479611 CDC25A cell division cycle 25A 2 2
MIRT481497 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 8
MIRT483117 SH3BP5 SH3 domain binding protein 5 2 2
MIRT502279 GRPEL2 GrpE like 2, mitochondrial 2 8
MIRT507838 CCNT1 cyclin T1 2 2
MIRT508179 MTRNR2L6 MT-RNR2-like 6 2 4
MIRT510576 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 6
MIRT517853 RPS4X ribosomal protein S4, X-linked 2 4
MIRT521690 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT525070 FRK fyn related Src family tyrosine kinase 2 2
MIRT527082 UBE2E3 ubiquitin conjugating enzyme E2 E3 2 2
MIRT529552 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530426 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT533909 TBC1D15 TBC1 domain family member 15 2 2
MIRT536627 IPO7 importin 7 2 2
MIRT537647 ERGIC2 ERGIC and golgi 2 2 4
MIRT538512 CLCN3 chloride voltage-gated channel 3 2 2
MIRT539219 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT539348 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT539954 CCT4 chaperonin containing TCP1 subunit 4 2 2
MIRT541208 HOXA10 homeobox A10 2 2
MIRT543216 TMEM117 transmembrane protein 117 2 2
MIRT543399 DROSHA drosha ribonuclease III 2 2
MIRT546648 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT546852 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT549917 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT552998 USP46 ubiquitin specific peptidase 46 2 2
MIRT555254 PREPL prolyl endopeptidase-like 2 2
MIRT555956 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT557095 HOXA9 homeobox A9 2 2
MIRT561396 TUBB2A tubulin beta 2A class IIa 2 2
MIRT561654 RNF219 ring finger protein 219 2 2
MIRT563101 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT565979 RNF44 ring finger protein 44 2 2
MIRT572396 CCDC14 coiled-coil domain containing 14 2 2
MIRT574400 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT607623 VSNL1 visinin like 1 2 2
MIRT610645 CTGF connective tissue growth factor 2 2
MIRT623379 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT624687 AR androgen receptor 2 2
MIRT632089 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT644216 CBS cystathionine-beta-synthase 2 2
MIRT647841 BID BH3 interacting domain death agonist 2 2
MIRT651649 WASF2 WAS protein family member 2 2 2
MIRT689064 AGMAT agmatinase 2 2
MIRT698150 TNPO1 transportin 1 2 2
MIRT700516 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT704081 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT705970 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT715694 COMMD3-BMI1 COMMD3-BMI1 readthrough 2 2
MIRT717184 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 2
MIRT724607 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT724854 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT725401 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-16-2 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-16-2-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-16-2-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-16-2-3p Bortezomib 387447 NSC681239 approved resistant Low Multiple Myeloma tissue
hsa-miR-16-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-16-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-16-2-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-16-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (HCT8)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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