pre-miRNA Information
pre-miRNA hsa-mir-5691   
Genomic Coordinates chr11: 9090312 - 9090379
Description Homo sapiens miR-5691 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-5691
Sequence 9| UUGCUCUGAGCUCCGAGAAAGC |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1042238449 3 dbSNP
rs554804494 11 dbSNP
rs1172229307 13 dbSNP
rs112511786 14 dbSNP
Putative Targets

Gene Information
Gene Symbol FADS6   
Synonyms FP18279
Description fatty acid desaturase 6
Transcript NM_178128   
Expression
Putative miRNA Targets on FADS6
3'UTR of FADS6
(miRNA target sites are highlighted)
>FADS6|NM_178128|3'UTR
   1 TGAGGCCGGGCCGGTGCAGCCACCCTGCCCCTCCCTGGCCTGGCCCTGGCCCTCCTGCTGCTGCTGGTCCAGGGGGTGTG
  81 GCTCAGTGGCTGGTGGTGGACCTGGAGAGTGGAGGCACCGGCCAGGCAGGGGGGCAGGGGAGCTCAGGCCTGGGGTCTGG
 161 GGGCCACCTGCCTTGCGTGCTTTTCTGGGTTTTGAGGGGTGTCTGGGTGAAGCGGTAATGGTGGCTGTGCATTCTGGTCA
 241 GTCTGGACCTCAGCAACTTCATCTCAGGACTAAAGAGCTGGGTCCTTCCCCCTGCTCCATCTGAGCCTTGGTAGGGTTAA
 321 AGGGAGGTGACAGGGTGAAGAGGGATCCTGTGCAGGGGCCACCTGGGAGATAGCAGGGGGCACAGAGAGAACAGGGTCAG
 401 CTCCCTCGGCTGGGACCTCCCTGGCATTGGGAGAGCCCCACACGGCCTTGGCTATTGCTTCCTTCAGGCTCTGCCCACCA
 481 AGGTGCCCTCTCCCCGGGGACCTTAGGGTGAGCTTGCTTTTGGCAGGCCTTCCTCGATCCTCAGCCAAAGGAACCTGTGC
 561 AAGACACTGGCTCAGCAGTTCCCCAGGCCACAGTATCAGCAAGATAAAAGTGAGTGTGTTTTGTCGGGAGGGAACTCCAG
 641 GGGAAGTGAGGGGAGAAGGTTCCCCAGGGACAGAGTTAGGGAAAGAGTATAAATAGCCAGCCAGGGGCGGTGGCTCATGC
 721 CTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCGCGAGATCAGGAGCTCGAGACCACCCTGGCCAACATGGTG
 801 AAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGATGTGGTGGCATACACTTGTAGTCCCAGCTACTTGGCAGGCT
 881 GAGGCAGAAGAATCACCTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATTGCACCATTGCATTCCAGCCTGGGTGA
 961 CAGAGCGAGACTCCATCTCAAAAAAATAAAAAAATAAAAAATAAGACTCCCGTTCAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgaaaGAGCCUCGAGUCUCGUu 5'
               || || |  ||||||: 
Target 5' ccagcCTGGGTG-ACAGAGCGa 3'
948 - 968 132.00 -16.40
2
miRNA  3' cgaaagagCCUCGAGUCUCguu 5'
                  ||:|| |||||   
Target 5' gatagcagGGGGCACAGAGaga 3'
369 - 390 118.00 -14.92
3
miRNA  3' cgaAAGAGCCUCGAGUCUCGuu 5'
             ||| |  :|  |||||:  
Target 5' aggTTCCCCAGGGACAGAGTta 3'
657 - 678 115.00 -9.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30148383 6 COSMIC
COSN30463884 34 COSMIC
COSN6549300 90 COSMIC
COSN18838189 344 COSMIC
COSN22504332 437 COSMIC
COSN17459240 755 COSMIC
COSN18972975 1008 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs537752819 7 dbSNP
rs746376376 8 dbSNP
rs1413705179 9 dbSNP
rs930222762 10 dbSNP
rs368141734 12 dbSNP
rs568829745 13 dbSNP
rs1435321624 18 dbSNP
rs1156637490 19 dbSNP
rs754032714 22 dbSNP
rs749922279 26 dbSNP
rs764352016 28 dbSNP
rs1242923806 33 dbSNP
rs1187195013 34 dbSNP
rs756354156 43 dbSNP
rs752735922 50 dbSNP
rs940962971 69 dbSNP
rs942818587 73 dbSNP
rs1274858561 75 dbSNP
rs1369305567 76 dbSNP
rs908104232 81 dbSNP
rs1285793253 86 dbSNP
rs769277234 87 dbSNP
rs954835202 89 dbSNP
rs1288343518 90 dbSNP
rs979064430 94 dbSNP
rs1188280358 98 dbSNP
rs548793678 108 dbSNP
rs1199687825 111 dbSNP
rs564236952 119 dbSNP
rs528941198 120 dbSNP
rs1178222419 129 dbSNP
rs969149551 130 dbSNP
rs1440058626 132 dbSNP
rs1160299540 133 dbSNP
rs1010212230 135 dbSNP
rs1021648557 135 dbSNP
rs956617492 135 dbSNP
rs1251362015 140 dbSNP
rs1032936436 142 dbSNP
rs560265764 143 dbSNP
rs1308050059 158 dbSNP
rs1378191455 162 dbSNP
rs1030885241 167 dbSNP
rs1242771360 169 dbSNP
rs1282726608 170 dbSNP
rs977368728 172 dbSNP
rs111985732 174 dbSNP
rs1273498199 176 dbSNP
rs149920976 177 dbSNP
rs1011979762 189 dbSNP
rs1459208409 194 dbSNP
rs898887410 196 dbSNP
rs1366454049 199 dbSNP
rs1472446626 200 dbSNP
rs1163740338 201 dbSNP
rs1037340247 205 dbSNP
rs690124 208 dbSNP
rs1400589770 209 dbSNP
rs565361888 214 dbSNP
rs1013914182 223 dbSNP
rs940325648 226 dbSNP
rs908135502 227 dbSNP
rs545638564 235 dbSNP
rs1286453024 246 dbSNP
rs1316210995 247 dbSNP
rs1034489005 248 dbSNP
rs1218100753 249 dbSNP
rs1258731784 256 dbSNP
rs745984433 266 dbSNP
rs1459280497 293 dbSNP
rs1198909039 294 dbSNP
rs531894594 296 dbSNP
rs1298785454 299 dbSNP
rs1441608475 306 dbSNP
rs1188235265 311 dbSNP
rs1259526085 314 dbSNP
rs562885826 329 dbSNP
rs1169365941 345 dbSNP
rs933521913 347 dbSNP
rs1170419058 349 dbSNP
rs1402010473 350 dbSNP
rs192532668 351 dbSNP
rs1315094689 356 dbSNP
rs922107253 358 dbSNP
rs888649341 359 dbSNP
rs1278956107 368 dbSNP
rs1397265532 378 dbSNP
rs1172218467 385 dbSNP
rs968844797 387 dbSNP
rs1255616570 388 dbSNP
rs914607709 389 dbSNP
rs690115 391 dbSNP
rs1192813225 392 dbSNP
rs988816253 392 dbSNP
rs930253741 395 dbSNP
rs1251910446 398 dbSNP
rs187915900 405 dbSNP
rs1041038657 407 dbSNP
rs757540632 408 dbSNP
rs540393012 410 dbSNP
rs911313397 425 dbSNP
rs1358984560 426 dbSNP
rs1419670280 426 dbSNP
rs1299322826 442 dbSNP
rs970989313 443 dbSNP
rs1385153723 444 dbSNP
rs1211157431 445 dbSNP
rs1023484413 450 dbSNP
rs1486479319 451 dbSNP
rs1236720393 457 dbSNP
rs1054246900 469 dbSNP
rs936762061 479 dbSNP
rs1232306716 488 dbSNP
rs925818393 495 dbSNP
rs370578781 496 dbSNP
rs1486767364 498 dbSNP
rs73997537 504 dbSNP
rs1266001382 507 dbSNP
rs185530190 508 dbSNP
rs1195084673 514 dbSNP
rs1307571137 523 dbSNP
rs1415605282 524 dbSNP
rs1159854681 527 dbSNP
rs1377543793 531 dbSNP
rs538083391 534 dbSNP
rs992510302 535 dbSNP
rs1004543294 536 dbSNP
rs572601348 540 dbSNP
rs958573861 542 dbSNP
rs1293047134 545 dbSNP
rs1034014151 556 dbSNP
rs1443444220 564 dbSNP
rs1005755436 566 dbSNP
rs1051991105 569 dbSNP
rs753617570 570 dbSNP
rs1239161044 573 dbSNP
rs933607085 575 dbSNP
rs772877821 576 dbSNP
rs1242471917 588 dbSNP
rs73997534 590 dbSNP
rs1161924324 592 dbSNP
rs1417928183 594 dbSNP
rs1410574043 602 dbSNP
rs1235974961 603 dbSNP
rs1381567644 604 dbSNP
rs1456992054 612 dbSNP
rs1188102307 614 dbSNP
rs1039213057 625 dbSNP
rs748612615 626 dbSNP
rs994268422 632 dbSNP
rs555726055 642 dbSNP
rs193179957 643 dbSNP
rs988888287 653 dbSNP
rs1329317014 654 dbSNP
rs200120760 659 dbSNP
rs1006899743 660 dbSNP
rs1213553240 662 dbSNP
rs1298568804 662 dbSNP
rs188305676 664 dbSNP
rs1287774078 675 dbSNP
rs1226587404 676 dbSNP
rs1311908876 676 dbSNP
rs73997533 678 dbSNP
rs981415410 690 dbSNP
rs970681221 695 dbSNP
rs1023938960 696 dbSNP
rs936774028 698 dbSNP
rs1204738126 703 dbSNP
rs1310860779 705 dbSNP
rs1395739264 707 dbSNP
rs1181854671 708 dbSNP
rs1257483179 718 dbSNP
rs990670127 732 dbSNP
rs1168647497 739 dbSNP
rs924007947 746 dbSNP
rs1041584811 751 dbSNP
rs945838108 752 dbSNP
rs917172171 754 dbSNP
rs992707630 755 dbSNP
rs1441542426 756 dbSNP
rs780766580 760 dbSNP
rs963540904 761 dbSNP
rs1015997688 762 dbSNP
rs1416494041 763 dbSNP
rs1275799227 769 dbSNP
rs1310383698 773 dbSNP
rs1214854685 776 dbSNP
rs1164963045 782 dbSNP
rs1475916897 783 dbSNP
rs1415138935 784 dbSNP
rs1004571230 785 dbSNP
rs1310004639 788 dbSNP
rs1428818036 793 dbSNP
rs140289164 795 dbSNP
rs1184602297 796 dbSNP
rs1192092301 799 dbSNP
rs1475777535 804 dbSNP
rs1464355947 806 dbSNP
rs983793419 807 dbSNP
rs530341942 808 dbSNP
rs1423331289 811 dbSNP
rs952584372 812 dbSNP
rs375917320 825 dbSNP
rs997559349 838 dbSNP
rs900758335 848 dbSNP
rs1025325793 849 dbSNP
rs994299439 850 dbSNP
rs1337042932 852 dbSNP
rs1436556962 853 dbSNP
rs1263824154 854 dbSNP
rs1359416982 858 dbSNP
rs1430823932 865 dbSNP
rs112441251 875 dbSNP
rs1019733798 904 dbSNP
rs1218234291 905 dbSNP
rs1298151167 912 dbSNP
rs1365358467 922 dbSNP
rs1433393940 933 dbSNP
rs1304683013 934 dbSNP
rs947616134 941 dbSNP
rs893294535 942 dbSNP
rs531834246 946 dbSNP
rs1053215569 951 dbSNP
rs1448015141 952 dbSNP
rs934748064 963 dbSNP
rs151208844 966 dbSNP
rs890025032 967 dbSNP
rs1194479395 971 dbSNP
rs1387946074 972 dbSNP
rs1395517862 972 dbSNP
rs1162191228 973 dbSNP
rs981473392 975 dbSNP
rs1359834061 978 dbSNP
rs1462159791 979 dbSNP
rs1005546986 987 dbSNP
rs796089390 987 dbSNP
rs1435377035 990 dbSNP
rs905887544 995 dbSNP
rs372508161 1002 dbSNP
rs950127035 1008 dbSNP
rs1448657542 1011 dbSNP
rs1253471741 1012 dbSNP
rs76510692 1015 dbSNP
rs1238442118 1016 dbSNP
rs867533919 1016 dbSNP
rs948690093 1016 dbSNP
rs867090785 1027 dbSNP
rs113393456 1030 dbSNP
rs1225937643 1030 dbSNP
rs1255125981 1030 dbSNP
rs201931533 1030 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000310226.6 | 3UTR | UGAGCACCACUGCACUCCAGCCUGGGUGACAGAGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000310226.6 | 3UTR | AGUGAGCACCACUGCACUCCAGCCUGGGUGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000310226.6 | 3UTR | UGAGCACCACUGCACUCCAGCCUGGGUGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
91 hsa-miR-5691 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT091162 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT242227 TTC9 tetratricopeptide repeat domain 9 2 4
MIRT246192 TXNIP thioredoxin interacting protein 2 2
MIRT251553 DCAF7 DDB1 and CUL4 associated factor 7 2 4
MIRT387267 SOX9 SRY-box 9 2 2
MIRT463486 ZC3H11A zinc finger CCCH-type containing 11A 2 12
MIRT494446 BTG2 BTG anti-proliferation factor 2 2 2
MIRT496478 ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 2 2
MIRT501825 NCOA3 nuclear receptor coactivator 3 2 2
MIRT503072 C6orf120 chromosome 6 open reading frame 120 2 2
MIRT504755 TEP1 telomerase associated protein 1 2 4
MIRT505971 RAB11FIP1 RAB11 family interacting protein 1 2 4
MIRT511868 GOLGA7 golgin A7 2 6
MIRT512900 UBL4A ubiquitin like 4A 2 2
MIRT513048 LYPD6 LY6/PLAUR domain containing 6 2 6
MIRT523772 FAM83D family with sequence similarity 83 member D 2 2
MIRT525126 RPS11 ribosomal protein S11 2 2
MIRT525816 VIMP selenoprotein S 2 10
MIRT531222 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT531729 SLC2A9 solute carrier family 2 member 9 2 2
MIRT536282 LIMA1 LIM domain and actin binding 1 2 2
MIRT537291 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT537724 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT547940 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 2
MIRT554177 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT555015 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT576717 Wars tryptophanyl-tRNA synthetase 2 2
MIRT607484 HEBP2 heme binding protein 2 2 2
MIRT610786 KLK2 kallikrein related peptidase 2 2 2
MIRT611491 ZNF440 zinc finger protein 440 2 2
MIRT613986 DBT dihydrolipoamide branched chain transacylase E2 2 2
MIRT615782 KIAA0319L KIAA0319 like 2 2
MIRT620563 WBSCR27 methyltransferase like 27 2 4
MIRT624157 DGKE diacylglycerol kinase epsilon 2 2
MIRT626088 MKLN1 muskelin 1 2 2
MIRT629481 GSN gelsolin 2 2
MIRT636645 CDK4 cyclin dependent kinase 4 2 2
MIRT638074 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT638442 PLXDC2 plexin domain containing 2 2 2
MIRT641025 KLHL7 kelch like family member 7 2 2
MIRT641539 MOCOS molybdenum cofactor sulfurase 2 2
MIRT643004 ZNF829 zinc finger protein 829 2 2
MIRT643092 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT644979 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT645912 PLXNA3 plexin A3 2 2
MIRT646605 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT648033 FADS6 fatty acid desaturase 6 2 2
MIRT657491 HBEGF heparin binding EGF like growth factor 2 2
MIRT658381 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT659695 CD200 CD200 molecule 2 2
MIRT661276 TEX9 testis expressed 9 2 2
MIRT661348 DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 2 2
MIRT662948 JPH2 junctophilin 2 2 2
MIRT663225 PPY pancreatic polypeptide 2 2
MIRT663280 SPN sialophorin 2 2
MIRT663335 ZNF74 zinc finger protein 74 2 2
MIRT664344 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664855 TBRG4 transforming growth factor beta regulator 4 2 2
MIRT665484 VPS53 VPS53, GARP complex subunit 2 2
MIRT666428 SH2B3 SH2B adaptor protein 3 2 2
MIRT668162 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT670170 CCDC142 coiled-coil domain containing 142 2 2
MIRT671277 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT672284 GP2 glycoprotein 2 2 2
MIRT672435 RAB10 RAB10, member RAS oncogene family 2 2
MIRT672646 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672760 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672834 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT672841 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT673080 AK1 adenylate kinase 1 2 2
MIRT673148 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673323 THAP1 THAP domain containing 1 2 2
MIRT673893 DCTN6 dynactin subunit 6 2 2
MIRT674182 PLEKHM3 pleckstrin homology domain containing M3 2 2
MIRT674607 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT674740 SLC16A1 solute carrier family 16 member 1 2 2
MIRT675140 MOGAT1 monoacylglycerol O-acyltransferase 1 2 4
MIRT675194 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT675886 SNAP29 synaptosome associated protein 29 2 2
MIRT679163 PSMB2 proteasome subunit beta 2 2 2
MIRT680337 ZNF281 zinc finger protein 281 2 2
MIRT706699 GPR155 G protein-coupled receptor 155 2 2
MIRT706911 THAP6 THAP domain containing 6 2 2
MIRT707880 SLC45A4 solute carrier family 45 member 4 2 2
MIRT709097 SEPT4 septin 4 2 2
MIRT709408 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT710845 FAM210A family with sequence similarity 210 member A 2 2
MIRT711358 VPS8 VPS8, CORVET complex subunit 2 2
MIRT718590 SCD5 stearoyl-CoA desaturase 5 2 2
MIRT723649 RPTN repetin 2 2
MIRT724208 NUP205 nucleoporin 205 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-5691 Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)

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