pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol TRAPPC2L   
Synonyms HSPC176
Description trafficking protein particle complex 2 like
Transcript NM_016209   
Expression
Putative miRNA Targets on TRAPPC2L
3'UTR of TRAPPC2L
(miRNA target sites are highlighted)
>TRAPPC2L|NM_016209|3'UTR
   1 GTGAGCTGTGCTGCCAGCCATCGCAGAGGAGCCCGCGCACGACTGTGGTGGGGCCGTCGGTCTGTTCTGGTTGCCTCTTC
  81 CTGAATGGGACGCCTGGGGCTTTCAGGGCAGGCAGCTGTGCATGTTCTCTCAACTAAAGGTCTTGTGAGAGGAGATTTGG
 161 CTTTTTCCTTCCGTGTCAGCCAAGGATTTAATTAAGAAGAATTCAACTAAGGACTTTTCTGGGGTGTGGGCAGAGGTTTG
 241 GGATCAGATGGCGCAGGTAGCCTGTCCTCAGTTGTCCCAAAGGGGCAGAGGCAGGGGTGCCTGGAGCCAAGAGTTCCTGA
 321 GCCTGCAGGACCTGTGACCATGTGGGTCACCCACTGGCTGAACAGGTGGGCTGGTCTGGAGGGGGTGGCCTCCTGAGCCC
 401 AGAACCAGCCTAGGATCTAGGGGCACAAGGGGAGCCGGCGTGGCTTCCCACAGGGGAGGGCCCTCCTCTTTCTGGACTTG
 481 GCCTCCATTCTTTGCATCTGGCTCAATGTCTGGATTCCGCCCGGCCTTAAAAGGAGCCCTTGTGAAACCTGGGAAGCCTC
 561 GTGGCCCCGCGGCGTTGGCTCAGCTGCAGCCCTGGTCCTAAACCTTGGAGCGCAGACTTGAGGCACCCCCTCCTGCCTGT
 641 TGGTGCTGAGGGGGTTGGGTGCTGTGTCACTTGATGACGTGGCTGACTACCACCCAGGGCAGCGGCCGAGCCCATAGTGG
 721 CGTCAGTGCCGCCGGCGTCCTTGGGGTCCAGCGGTCAAGGCTCAGCCCGCTGAGGGGACCCCCCCGGAGTTGGTTCCAGC
 801 ACTGGTCCAGGACTGGAGAGTTTCTCAAGGACCTTGAGGACCCCAGAAGCCCTTGCAGCAGGAAAGGCTGTAAGGGGGGG
 881 TCAGCCTAGGGCAGGACCTAGGGAGGGGAACTTTCTTGATACATATTTGCCTTTTCATCCCATCTAGCAAGCACAGTGTT
 961 AATTTTAGAAATTATAGAAGAAAAAATCAGCAAGGAGTGTGGGAAAACTGCATGCCCCAGGCCTCCCCCGCCCCAGGGTG
1041 AATTGGAAGCCCTGGAATGGGCCGAGGCACACCAGGCAGCTGATCTGGGTGCATGTGGGCCACAGACCACTCTCACAAGG
1121 TTAAATCTTTAACAAGAGCCTCATGTTTGTTAGGAGAAGGTGGGACCCCAGCCCAAGCACTTCCCCATTGCAGCCTGGCA
1201 TGAAATCTTTGCCTTTTAGTGGGGATCACTCCTGCCCGAGTCCTGGCTGTGGTGGGGACTCTGCAAGTTGCTAACCCAGC
1281 GTCCATTCTCTTTCCTCCGTACTAACAGAACCCCGGTGCCTCTGCCCAGTTCCAATAGCGGGCAGACGAGAGCCATGTCC
1361 TGGGCTCCCTTGCAGCCCGGGGTGTGCAGCTGTGGCGTGGAGGTGGGTGGTGCTGGGAGAGACTTGCAGGGAAGCTCCTG
1441 TGAAGGGGACTCAGCTGCCACATGCAGGACCCTTCCCCTTTGCCTTCTTCCTGCCTGGAACATGGATGTGATGGCTGGTG
1521 CTGGGACAGCTGTCCTGAGAGCGTGAGGAAAGGGTCACACCCTAAGGACAGTGGAGCAGAACACAGGAAGGACCCTGGGC
1601 CTTTGCTGACGCAGAACGCGGGAAGGACCCTGGGCCTTTGCTGACATACCAGCCCCAGACTACTTAAATTCAGCTTTTTT
1681 TTTAATGTGAGAAAATAAATGCACCCCTCTCTGGTTTAAGCCACTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' auGCGGUC---AGUUAU-----GGAACACu 5'
            |||| |   |:|| |     ||||||| 
Target 5' tcCGCCCGGCCTTAAAAGGAGCCCTTGTGa 3'
516 - 545 152.00 -19.70
2
miRNA  3' auGCGGUCAGUUAUGGAACACu 5'
            | | | | || ::|||||| 
Target 5' ctCTCAACTAAAGGTCTTGTGa 3'
127 - 148 140.00 -10.60
3
miRNA  3' augCGGUCAGUU-AUGGAACACu 5'
             |::  ||||  |||||| | 
Target 5' agaGTTTCTCAAGGACCTTGAGg 3'
817 - 839 123.00 -11.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24381857 44 COSMIC
COSN29673957 57 COSMIC
COSN31611127 64 COSMIC
COSN31513498 99 COSMIC
COSN31580329 200 COSMIC
COSN26437297 569 COSMIC
COSN14955240 609 COSMIC
COSN31556417 632 COSMIC
COSN30164929 633 COSMIC
COSM4447365 669 COSMIC
COSM6202845 704 COSMIC
COSM6016344 709 COSMIC
COSM8400849 711 COSMIC
COSM8889386 731 COSMIC
COSN31550117 752 COSMIC
COSN28836611 786 COSMIC
COSN31957549 879 COSMIC
COSN20750203 1205 COSMIC
COSN31603683 1229 COSMIC
COSN31582071 1300 COSMIC
COSN18882223 1595 COSMIC
COSN9446184 1607 COSMIC
COSN16528611 1630 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1271154557 1 dbSNP
rs1467887329 2 dbSNP
rs1195554960 3 dbSNP
rs1193607982 4 dbSNP
rs1243531413 6 dbSNP
rs1474222228 9 dbSNP
rs750031456 14 dbSNP
rs201159776 15 dbSNP
rs1447232044 16 dbSNP
rs963289308 18 dbSNP
rs779565442 20 dbSNP
rs748633180 21 dbSNP
rs537493943 23 dbSNP
rs370268135 24 dbSNP
rs1046540 27 dbSNP
rs1347242157 29 dbSNP
rs1428905922 32 dbSNP
rs554186746 33 dbSNP
rs776839360 35 dbSNP
rs144667215 36 dbSNP
rs1291414452 37 dbSNP
rs769798928 38 dbSNP
rs775611413 39 dbSNP
rs527461819 41 dbSNP
rs182443459 42 dbSNP
rs1461039971 44 dbSNP
rs148176490 44 dbSNP
rs761707782 45 dbSNP
rs767361906 48 dbSNP
rs1172778629 49 dbSNP
rs375869560 52 dbSNP
rs912622561 56 dbSNP
rs753830918 57 dbSNP
rs1191350753 58 dbSNP
rs375610880 59 dbSNP
rs1244683289 60 dbSNP
rs1212501410 61 dbSNP
rs1457856288 68 dbSNP
rs998860808 73 dbSNP
rs781585577 74 dbSNP
rs1465839498 76 dbSNP
rs1259225239 80 dbSNP
rs1201099505 82 dbSNP
rs186781851 88 dbSNP
rs1033468292 91 dbSNP
rs957470635 92 dbSNP
rs1013440625 93 dbSNP
rs141980662 95 dbSNP
rs14489 96 dbSNP
rs981622596 99 dbSNP
rs1440219719 100 dbSNP
rs1377781303 101 dbSNP
rs529694538 111 dbSNP
rs908800913 114 dbSNP
rs547871710 115 dbSNP
rs1460413199 116 dbSNP
rs1353935679 119 dbSNP
rs1001080162 121 dbSNP
rs1347386544 128 dbSNP
rs1392848066 130 dbSNP
rs1439724481 134 dbSNP
rs1239480888 135 dbSNP
rs1398033012 137 dbSNP
rs971696049 140 dbSNP
rs147299835 142 dbSNP
rs527960125 143 dbSNP
rs1479941364 145 dbSNP
rs552380007 146 dbSNP
rs570730131 148 dbSNP
rs1278407683 149 dbSNP
rs1050619274 152 dbSNP
rs112196633 155 dbSNP
rs1352779201 162 dbSNP
rs1311556473 169 dbSNP
rs1024757641 171 dbSNP
rs1372502615 172 dbSNP
rs537550400 173 dbSNP
rs944533431 174 dbSNP
rs1002078643 176 dbSNP
rs1292075477 177 dbSNP
rs1487622803 180 dbSNP
rs538012733 182 dbSNP
rs1419936574 183 dbSNP
rs1156296847 184 dbSNP
rs1418051016 185 dbSNP
rs903100726 186 dbSNP
rs556244331 190 dbSNP
rs1182981763 194 dbSNP
rs1486828579 195 dbSNP
rs1264388410 200 dbSNP
rs568213304 205 dbSNP
rs1288491628 209 dbSNP
rs1236936936 210 dbSNP
rs1054441370 212 dbSNP
rs1313283043 213 dbSNP
rs1229974315 215 dbSNP
rs1353259350 215 dbSNP
rs973334509 218 dbSNP
rs112846826 219 dbSNP
rs1400446279 219 dbSNP
rs1362039372 220 dbSNP
rs1286797277 222 dbSNP
rs1194896553 226 dbSNP
rs951440014 227 dbSNP
rs1368559488 236 dbSNP
rs755298143 237 dbSNP
rs1457092504 240 dbSNP
rs1023476043 241 dbSNP
rs1163372222 242 dbSNP
rs983180680 243 dbSNP
rs1187655397 251 dbSNP
rs572476192 253 dbSNP
rs1002994349 254 dbSNP
rs1015747247 258 dbSNP
rs1485552622 265 dbSNP
rs1266114565 273 dbSNP
rs1215706854 276 dbSNP
rs1039728102 277 dbSNP
rs1292650232 285 dbSNP
rs553865424 300 dbSNP
rs777421785 301 dbSNP
rs921447115 307 dbSNP
rs72462898 309 dbSNP
rs1053989623 311 dbSNP
rs892697911 316 dbSNP
rs1310311802 324 dbSNP
rs1294767047 329 dbSNP
rs945098700 330 dbSNP
rs974755431 332 dbSNP
rs1392885380 334 dbSNP
rs1164875864 335 dbSNP
rs920251980 341 dbSNP
rs1375157505 351 dbSNP
rs1245767137 355 dbSNP
rs951815690 372 dbSNP
rs1046487802 377 dbSNP
rs985864902 379 dbSNP
rs34829002 381 dbSNP
rs1268392565 383 dbSNP
rs910297633 385 dbSNP
rs1467226669 386 dbSNP
rs112344905 387 dbSNP
rs1033403655 388 dbSNP
rs540179695 389 dbSNP
rs924470318 393 dbSNP
rs934538935 395 dbSNP
rs1199166894 410 dbSNP
rs1026263061 419 dbSNP
rs1303012089 428 dbSNP
rs1054792484 431 dbSNP
rs1325754057 432 dbSNP
rs987366517 438 dbSNP
rs756787246 440 dbSNP
rs942397797 441 dbSNP
rs965320479 448 dbSNP
rs1378390775 451 dbSNP
rs1452603228 460 dbSNP
rs1187748726 469 dbSNP
rs77782655 470 dbSNP
rs1044441352 480 dbSNP
rs907289473 482 dbSNP
rs184838883 483 dbSNP
rs1015696144 484 dbSNP
rs1157517105 487 dbSNP
rs1248400830 495 dbSNP
rs1194985416 496 dbSNP
rs535137731 497 dbSNP
rs995745676 498 dbSNP
rs1027658014 500 dbSNP
rs1455259242 502 dbSNP
rs562618330 503 dbSNP
rs1444172643 509 dbSNP
rs1443819045 512 dbSNP
rs771959956 519 dbSNP
rs768717546 520 dbSNP
rs140877975 523 dbSNP
rs188908020 524 dbSNP
rs975846556 533 dbSNP
rs924409919 534 dbSNP
rs559869033 537 dbSNP
rs112323037 540 dbSNP
rs1471224303 541 dbSNP
rs1239586926 543 dbSNP
rs1310073159 551 dbSNP
rs1181033043 557 dbSNP
rs1442733954 558 dbSNP
rs192943118 561 dbSNP
rs761985131 566 dbSNP
rs914470864 567 dbSNP
rs570766417 569 dbSNP
rs948698739 570 dbSNP
rs531834319 571 dbSNP
rs907235687 572 dbSNP
rs549954008 573 dbSNP
rs1356421327 574 dbSNP
rs1026568553 575 dbSNP
rs1456170814 576 dbSNP
rs1413382351 582 dbSNP
rs938745090 587 dbSNP
rs1375047876 594 dbSNP
rs886238198 598 dbSNP
rs1037091857 607 dbSNP
rs568576418 612 dbSNP
rs770734044 613 dbSNP
rs535556484 616 dbSNP
rs554211275 618 dbSNP
rs755751233 621 dbSNP
rs757264416 626 dbSNP
rs1475165190 628 dbSNP
rs1157862284 629 dbSNP
rs765846973 630 dbSNP
rs1420009795 631 dbSNP
rs1018840343 633 dbSNP
rs1410626277 634 dbSNP
rs1027196511 636 dbSNP
rs753362746 637 dbSNP
rs965374585 638 dbSNP
rs758883240 640 dbSNP
rs778245831 641 dbSNP
rs975371924 642 dbSNP
rs1215909049 644 dbSNP
rs1249280382 648 dbSNP
rs1336086875 652 dbSNP
rs1463269364 654 dbSNP
rs751993508 655 dbSNP
rs757643439 659 dbSNP
rs1354801796 663 dbSNP
rs1239703882 665 dbSNP
rs1231803395 671 dbSNP
rs1355253195 672 dbSNP
rs1281149374 673 dbSNP
rs1348319514 674 dbSNP
rs1222947244 676 dbSNP
rs781500241 679 dbSNP
rs1007172878 680 dbSNP
rs746132631 681 dbSNP
rs778360504 683 dbSNP
rs1256177810 684 dbSNP
rs368238349 686 dbSNP
rs1183204824 689 dbSNP
rs143200032 692 dbSNP
rs1468968165 693 dbSNP
rs749383533 694 dbSNP
rs1395988451 695 dbSNP
rs763152651 696 dbSNP
rs768553275 698 dbSNP
rs1171942114 700 dbSNP
rs1374935156 701 dbSNP
rs1162018022 703 dbSNP
rs376628343 704 dbSNP
rs369901032 705 dbSNP
rs866737955 706 dbSNP
rs147390553 708 dbSNP
rs369180471 709 dbSNP
rs1469448239 712 dbSNP
rs372922390 713 dbSNP
rs1212384966 717 dbSNP
rs1349674796 718 dbSNP
rs766037468 719 dbSNP
rs1279113843 721 dbSNP
rs4530120 722 dbSNP
rs369666016 723 dbSNP
rs868449021 724 dbSNP
rs1275767283 725 dbSNP
rs1360108029 726 dbSNP
rs11864319 729 dbSNP
rs377424160 731 dbSNP
rs753497487 732 dbSNP
rs1455808577 733 dbSNP
rs756907030 734 dbSNP
rs371244104 735 dbSNP
rs780329136 737 dbSNP
rs373208959 738 dbSNP
rs1394332789 741 dbSNP
rs1465027160 744 dbSNP
rs1418308942 745 dbSNP
rs779095488 746 dbSNP
rs1372952086 749 dbSNP
rs1438379622 750 dbSNP
rs938694125 751 dbSNP
rs748136543 753 dbSNP
rs80333666 754 dbSNP
rs773195166 755 dbSNP
rs1272497965 760 dbSNP
rs139080306 762 dbSNP
rs770562414 764 dbSNP
rs1040724607 765 dbSNP
rs60612036 766 dbSNP
rs776356867 767 dbSNP
rs900420044 768 dbSNP
rs149887085 769 dbSNP
rs560155961 770 dbSNP
rs752184052 771 dbSNP
rs1371421700 774 dbSNP
rs1353723243 775 dbSNP
rs762369166 776 dbSNP
rs1165589131 777 dbSNP
rs1436198736 778 dbSNP
rs1172452180 779 dbSNP
rs745409928 779 dbSNP
rs1396564877 780 dbSNP
rs1011422741 781 dbSNP
rs1292723418 782 dbSNP
rs768007948 785 dbSNP
rs76042178 786 dbSNP
rs756516512 787 dbSNP
rs1325383584 790 dbSNP
rs1212128641 794 dbSNP
rs1486768849 795 dbSNP
rs749870880 799 dbSNP
rs1041326201 800 dbSNP
rs1233615160 801 dbSNP
rs1273202429 802 dbSNP
rs1308877235 806 dbSNP
rs1218823891 808 dbSNP
rs545393388 809 dbSNP
rs1222014118 810 dbSNP
rs374448334 821 dbSNP
rs564483258 827 dbSNP
rs1293670389 828 dbSNP
rs1416442778 829 dbSNP
rs1490506232 833 dbSNP
rs1311927231 835 dbSNP
rs901467419 836 dbSNP
rs1453794679 837 dbSNP
rs1201438092 840 dbSNP
rs1338047865 842 dbSNP
rs1260803042 843 dbSNP
rs928239314 846 dbSNP
rs1417848761 848 dbSNP
rs543304197 852 dbSNP
rs1411950095 857 dbSNP
rs140367485 865 dbSNP
rs531868901 868 dbSNP
rs1031375000 871 dbSNP
rs147303347 874 dbSNP
rs1200112794 875 dbSNP
rs955968499 876 dbSNP
rs1011348480 877 dbSNP
rs1021852615 879 dbSNP
rs1427149363 881 dbSNP
rs368497186 883 dbSNP
rs1406378745 886 dbSNP
rs969930927 890 dbSNP
rs1353355204 898 dbSNP
rs930302047 900 dbSNP
rs549992582 906 dbSNP
rs1286597641 911 dbSNP
rs1452488667 917 dbSNP
rs1047960158 923 dbSNP
rs12597391 924 dbSNP
rs1040181756 925 dbSNP
rs1401055454 926 dbSNP
rs1272282123 927 dbSNP
rs144873381 932 dbSNP
rs1184825049 937 dbSNP
rs959986895 940 dbSNP
rs1464526571 941 dbSNP
rs1226233279 947 dbSNP
rs1273686210 948 dbSNP
rs1215503934 950 dbSNP
rs1332319355 952 dbSNP
rs1264633066 954 dbSNP
rs1227959895 956 dbSNP
rs547583206 958 dbSNP
rs996059514 965 dbSNP
rs1381120248 969 dbSNP
rs1054273836 976 dbSNP
rs1443748137 976 dbSNP
rs1392993506 977 dbSNP
rs1163021968 978 dbSNP
rs566117682 981 dbSNP
rs1374963716 982 dbSNP
rs76010343 989 dbSNP
rs374825831 990 dbSNP
rs1448881302 992 dbSNP
rs746989660 995 dbSNP
rs1048494310 996 dbSNP
rs1195648910 997 dbSNP
rs1283724643 1000 dbSNP
rs1487913345 1001 dbSNP
rs1196127261 1011 dbSNP
rs1010892581 1015 dbSNP
rs911343635 1019 dbSNP
rs942883498 1022 dbSNP
rs1227228223 1024 dbSNP
rs1304975380 1028 dbSNP
rs114574988 1030 dbSNP
rs1323522595 1031 dbSNP
rs1035193555 1034 dbSNP
rs1399102794 1036 dbSNP
rs573963710 1045 dbSNP
rs12596491 1051 dbSNP
rs560393846 1058 dbSNP
rs951831570 1065 dbSNP
rs763620235 1068 dbSNP
rs1182465038 1069 dbSNP
rs769865277 1071 dbSNP
rs773569848 1074 dbSNP
rs891478517 1080 dbSNP
rs1485782339 1081 dbSNP
rs1320744242 1083 dbSNP
rs1357732443 1086 dbSNP
rs1011713334 1090 dbSNP
rs1343707280 1093 dbSNP
rs944475185 1094 dbSNP
rs975772333 1098 dbSNP
rs921783296 1099 dbSNP
rs1286832176 1103 dbSNP
rs538114582 1104 dbSNP
rs1445398616 1110 dbSNP
rs1335589783 1115 dbSNP
rs931794150 1123 dbSNP
rs1021382387 1124 dbSNP
rs1401600425 1125 dbSNP
rs1054326562 1126 dbSNP
rs1362043442 1128 dbSNP
rs893043017 1128 dbSNP
rs1181151976 1132 dbSNP
rs970257105 1134 dbSNP
rs1042393202 1136 dbSNP
rs1208301725 1143 dbSNP
rs1247606173 1155 dbSNP
rs1284343087 1156 dbSNP
rs902477683 1160 dbSNP
rs763064621 1163 dbSNP
rs1035080275 1167 dbSNP
rs879187074 1168 dbSNP
rs1035522272 1170 dbSNP
rs1295288514 1181 dbSNP
rs1224224372 1184 dbSNP
rs959936912 1188 dbSNP
rs895340135 1194 dbSNP
rs556392543 1201 dbSNP
rs1286122987 1205 dbSNP
rs972650733 1206 dbSNP
rs1319042151 1214 dbSNP
rs1440418845 1219 dbSNP
rs116775328 1223 dbSNP
rs77639392 1233 dbSNP
rs952328707 1235 dbSNP
rs984570296 1237 dbSNP
rs185127615 1238 dbSNP
rs1014601851 1239 dbSNP
rs1194653020 1241 dbSNP
rs1176894776 1247 dbSNP
rs189764554 1253 dbSNP
rs1246670973 1254 dbSNP
rs976904458 1256 dbSNP
rs1208663930 1257 dbSNP
rs1335824582 1259 dbSNP
rs1470809570 1263 dbSNP
rs545430987 1264 dbSNP
rs922788005 1268 dbSNP
rs1355872628 1270 dbSNP
rs1271024515 1280 dbSNP
rs935545506 1281 dbSNP
rs1363138737 1284 dbSNP
rs921670375 1289 dbSNP
rs1396678498 1291 dbSNP
rs1052714273 1294 dbSNP
rs1404588995 1295 dbSNP
rs891423152 1296 dbSNP
rs914349739 1297 dbSNP
rs945991550 1299 dbSNP
rs371987926 1300 dbSNP
rs563717880 1302 dbSNP
rs28562362 1303 dbSNP
rs1193791962 1307 dbSNP
rs1043156430 1313 dbSNP
rs902529281 1314 dbSNP
rs939315104 1315 dbSNP
rs575605010 1316 dbSNP
rs1001270148 1320 dbSNP
rs1273906887 1323 dbSNP
rs1035471309 1327 dbSNP
rs895674293 1328 dbSNP
rs1334622401 1329 dbSNP
rs1296953372 1333 dbSNP
rs1442845003 1336 dbSNP
rs543722831 1337 dbSNP
rs1025560289 1340 dbSNP
rs952774944 1341 dbSNP
rs181198316 1346 dbSNP
rs1012459697 1348 dbSNP
rs1173689932 1349 dbSNP
rs1325981783 1350 dbSNP
rs1198986014 1351 dbSNP
rs1027826787 1352 dbSNP
rs1477868864 1353 dbSNP
rs1196925696 1357 dbSNP
rs1233819039 1360 dbSNP
rs563959724 1367 dbSNP
rs1257534680 1368 dbSNP
rs529466636 1370 dbSNP
rs547965396 1379 dbSNP
rs559631140 1382 dbSNP
rs533447977 1383 dbSNP
rs1015571034 1387 dbSNP
rs964105542 1389 dbSNP
rs375027837 1390 dbSNP
rs1369515342 1396 dbSNP
rs775666863 1397 dbSNP
rs1200663226 1398 dbSNP
rs1028737134 1414 dbSNP
rs953133357 1417 dbSNP
rs531271812 1418 dbSNP
rs1409420178 1422 dbSNP
rs988760236 1436 dbSNP
rs1184748527 1438 dbSNP
rs914423217 1440 dbSNP
rs542159110 1447 dbSNP
rs750956429 1453 dbSNP
rs967591100 1455 dbSNP
rs977389389 1456 dbSNP
rs915493989 1463 dbSNP
rs146729519 1468 dbSNP
rs1330307141 1470 dbSNP
rs1209579285 1474 dbSNP
rs1317419610 1484 dbSNP
rs939367661 1485 dbSNP
rs1329315022 1489 dbSNP
rs756369824 1490 dbSNP
rs1042717376 1491 dbSNP
rs1293457073 1494 dbSNP
rs916546293 1495 dbSNP
rs549832223 1499 dbSNP
rs937070202 1505 dbSNP
rs1301731929 1506 dbSNP
rs1347112694 1509 dbSNP
rs1056824174 1524 dbSNP
rs1346264132 1539 dbSNP
rs780535900 1542 dbSNP
rs1217033851 1543 dbSNP
rs948127381 1543 dbSNP
rs1411691328 1544 dbSNP
rs764813806 1547 dbSNP
rs1250912018 1552 dbSNP
rs1049586095 1553 dbSNP
rs1254391306 1557 dbSNP
rs140364140 1559 dbSNP
rs1486248796 1561 dbSNP
rs1249751984 1562 dbSNP
rs1197695549 1563 dbSNP
rs1005444918 1565 dbSNP
rs1234964983 1571 dbSNP
rs1287772913 1572 dbSNP
rs1036647338 1577 dbSNP
rs386794063 1583 dbSNP
rs375827029 1584 dbSNP
rs1382246853 1585 dbSNP
rs1181531977 1586 dbSNP
rs1323055952 1586 dbSNP
rs375803975 1586 dbSNP
rs994010961 1587 dbSNP
rs377604539 1595 dbSNP
rs71158762 1595 dbSNP
rs71276835 1595 dbSNP
rs74035871 1595 dbSNP
rs144003827 1596 dbSNP
rs1481672576 1597 dbSNP
rs1326969560 1602 dbSNP
rs1459803805 1603 dbSNP
rs1366896112 1609 dbSNP
rs537404949 1611 dbSNP
rs997682568 1612 dbSNP
rs1005904591 1616 dbSNP
rs1477013285 1616 dbSNP
rs867487634 1618 dbSNP
rs1018250632 1619 dbSNP
rs116112654 1620 dbSNP
rs568343465 1621 dbSNP
rs1343938321 1627 dbSNP
rs1294748963 1629 dbSNP
rs11641280 1630 dbSNP
rs1388831308 1635 dbSNP
rs1389033400 1637 dbSNP
rs1293377960 1644 dbSNP
rs75898184 1645 dbSNP
rs553918943 1653 dbSNP
rs1372697166 1654 dbSNP
rs1166767199 1656 dbSNP
rs1021774002 1659 dbSNP
rs749499699 1661 dbSNP
rs1029755917 1675 dbSNP
rs1431165382 1675 dbSNP
rs201132762 1675 dbSNP
rs571838485 1677 dbSNP
rs956814378 1678 dbSNP
rs1196214912 1686 dbSNP
rs1483818881 1687 dbSNP
rs1423961319 1693 dbSNP
rs1272087125 1698 dbSNP
rs988319677 1707 dbSNP
rs1348002422 1708 dbSNP
rs928609868 1712 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000301021.3 | 3UTR | GAGAGGAGAUUUGGCUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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