pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol TMEM169   
Synonyms -
Description transmembrane protein 169
Transcript NM_001142310   
Other Transcripts NM_001142311 , NM_001142312 , NM_138390   
Expression
Putative miRNA Targets on TMEM169
3'UTR of TMEM169
(miRNA target sites are highlighted)
>TMEM169|NM_001142310|3'UTR
   1 ACTCCCAACAACTTACTCCCTCCTCTGGCCCCAGTAGCCTATATATCATCTTAAAATTCCAGCAGATTATTTCTTTAAAT
  81 TACCCCCTACTCTCCGCAGTTCTTCTGGGAAATCAGAGTCCATACTGATCAGTTTTACCATCTTGAGGGTTCCAGGAGGG
 161 CATGGAGCAGACAAGCAATTGTGCCAAAGCAGTTCACCCAATGGACAAACTCTTTTTGATTCCCTGCCCTAAAATCACCA
 241 TTTATTTAGGACAATGGAACTCTGCTGTGTGTCGTTTTGGGAGCCTGGAAGTGTTACTGGTGCCTGGAACTGAGGGGAGT
 321 ATGTGACTAAATGTGTCAGGGAGAATAAAGAACCTCGGGGTAACCAAATCCACCAAGATAATAGACAGGGATGGAGTGAG
 401 ACATTTAGGAAGCTGGACTACCACAGTGTAGCAGAAGGTAAAGATTTGTGTGTATCATTTAGATTTAGATTTAGCTGCAT
 481 AGAATTAAAACCCTAAAATATCAGTGGCTTAAACAAGATAGAAGTGTATTTCTTTCTTGTGCAGAAGAAGTCTGGAGGCA
 561 GACCATCCTGGGACCCTGTGAAGTAATCCAGGTCCCAGGCTTCTTCTATTTCTCTACCATTAGTAGGATGTGACCCTTCT
 641 CACCCTTATCCCCAACATCCCAGTGCTGATTACATCTTCAGCCATCACATCCATGTTTCTGATAAAATAGAGGAAAGGGC
 721 AGAGAAGCACACACCCTTCCTGTTCAAGGAGACTTCCCAGAAGTCCCACTCGATTCTTCTTATATCTCATTGGCAAGACC
 801 TCAGTCACATGATGTCATGAGCAAAAGAGGCTGGAAATGTAGTTGTTTGGCTGGGTAGCTATATTCTCAGCTAAATACTG
 881 GGTTCACGCTAATTGGCAAGAAAAAGGAAGAATGGTTATTTGGGTTTTGTTTTGTTTTGTTTTGTTTCGCTTTAGAGACG
 961 GAGTCTCACTCTGTTGCCGAGGCTGGAGTGCAGTGGCACTATCTCGGCTCACTGCAACCTTCGCCTCCTGGGTTCAAGCA
1041 ATTCTTGTGCCTTGGCCTCCCCAGTAGCTGGGATTACAGGTGCGTGCCACCATACCCGGCTAATTTTTGTATTTTTTTTT
1121 TAGTAGAGATGGGGTTTCACCATGTGCCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCC
1201 AAAATGCTGGGATTGTAGGCAAGAATGGTTATCTTGGTAGGCAAGTCAGAATCTTTGCCTCACAATGATCATTTAAATAC
1281 ATTCAGAACCCCCAAACTGCTAATATGGTTTTATTTATTTATTTATTCATTCATTTGTTTATTCATTTATTTATTTAGGC
1361 CTGAATCTTACACAGAGAATTTATATATAGATATTAGCTACATATACTTTGAATATGCTATACATCGATATTAGCACCTC
1441 ACGTACTTTGCAATTAAGCTTCTGTAATGTCATGTGATTTGTTTTTGGAAAGGAATAGTGGACAGGAGAGTACAATTTAT
1521 AATAGTAGCATAACTCTTTGTCCTGGTGGTGGAGGTGGGACGAGGTGGTGATATTTAACCTAGATTAAAGACCAGGAAGG
1601 GAGGAATTGCATCTGCCAAAGTTTCCTCCAACAGCGATCAGTAGCCCTAAGTACAAAGAAGCCAGATTTAGCCTTCTGTT
1681 GTTTGGCAAAACCTCACTCAGAGCTTTACTCCCTCAGACCTTTCTGAGTTTAACCACAGACATGATCTTTGCTGTGCTGA
1761 GAAACTTGTGTCTACCTGGCCTGTAGGGAGTGTAAACTAGATTAATACAGATTAACAGACTCTGAACTTAAAAAAAAAAA
1841 TCACTCCTAAGGGTGTCCTTCTAATTTCAAAATATCAACTCCTAAGAGGTCAGCAGAATTTGGAGATTTGGGTCCTTATA
1921 AGAATAGCTGGTGCTCTTTTCTTGTTCATGTCTCAAAACAAAGCTGTTGAGAGAACTGCTGCGATGAATCAAACCAGAGG
2001 AGTTTGTCATGCTCCCCACAGAGAGCCCAGGACATTTGCCTGATGTATGGTGCTGAGCTCCACCTTCAGAGGAACTCTCT
2081 CTTTTTTTTTTTTTTAAATAACTATTATTAGCTTGACAAGAAAAAAAAAGTGCCCAACAGTTTTAGTGTTAATCTTGGTG
2161 CTCTATGGTGCATTAGCAGAGATATGAACAATTAAATGAAGACAAAGAAAATAAAAATAAAGTCTGATTAACTTTTGCTC
2241 AAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccccAC-CCCUGUCUCCGAa 5'
                || |  | ||||||| 
Target 5' atgtcaTGAGCAAAAGAGGCTg 3'
812 - 833 143.00 -9.40
2
miRNA  3' gaccccaccccuguCUCCGAa 5'
                        |||||| 
Target 5' ctcactctgttgccGAGGCTg 3'
965 - 985 120.00 -7.80
3
miRNA  3' gaccccaccccuGUCUCCGAa 5'
                      ||| |||| 
Target 5' accctaaaatatCAGTGGCTt 3'
490 - 510 113.00 -9.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM476890 1 COSMIC
COSN30477560 19 COSMIC
COSN30454032 20 COSMIC
COSN31546538 74 COSMIC
COSN28710317 90 COSMIC
COSN30144639 94 COSMIC
COSN31502498 100 COSMIC
COSN30101384 146 COSMIC
COSN20074566 150 COSMIC
COSN16406799 162 COSMIC
COSN8608598 167 COSMIC
COSN26671042 176 COSMIC
COSN6938386 212 COSMIC
COSN25357679 390 COSMIC
COSN30341351 752 COSMIC
COSN25177327 926 COSMIC
COSN25757279 1007 COSMIC
COSN27095377 1422 COSMIC
COSN8766216 1689 COSMIC
COSN27441189 1841 COSMIC
COSN31487248 1932 COSMIC
COSN31484366 1984 COSMIC
COSN31588527 1995 COSMIC
COSN31563740 2002 COSMIC
COSN6938387 2003 COSMIC
COSN26647854 2028 COSMIC
COSN26788628 2084 COSMIC
COSN6938388 2129 COSMIC
COSN14548805 2168 COSMIC
COSN31551045 2170 COSMIC
COSN29463550 2179 COSMIC
COSN31607958 2208 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763521905 3 dbSNP
rs1341776979 5 dbSNP
rs896399320 9 dbSNP
rs1309184869 13 dbSNP
rs769122668 15 dbSNP
rs774467506 19 dbSNP
rs368605893 28 dbSNP
rs372281249 29 dbSNP
rs376821522 30 dbSNP
rs536681427 32 dbSNP
rs1206969789 37 dbSNP
rs1351597240 39 dbSNP
rs765182416 40 dbSNP
rs752507506 49 dbSNP
rs758457739 50 dbSNP
rs777874573 53 dbSNP
rs1239969668 63 dbSNP
rs887585264 80 dbSNP
rs1274788323 83 dbSNP
rs1005947366 85 dbSNP
rs1017270820 88 dbSNP
rs1344865437 88 dbSNP
rs1303680816 90 dbSNP
rs1225533392 93 dbSNP
rs142701998 96 dbSNP
rs73056600 97 dbSNP
rs1157660986 98 dbSNP
rs1453964019 103 dbSNP
rs1365155449 113 dbSNP
rs1030367935 117 dbSNP
rs1174463537 118 dbSNP
rs1262690967 133 dbSNP
rs554841362 136 dbSNP
rs574948271 137 dbSNP
rs1270321852 138 dbSNP
rs1202142225 145 dbSNP
rs1056898959 146 dbSNP
rs896470631 158 dbSNP
rs544024312 164 dbSNP
rs773614348 173 dbSNP
rs897670773 174 dbSNP
rs1283862079 176 dbSNP
rs994634465 185 dbSNP
rs968169575 191 dbSNP
rs979519352 194 dbSNP
rs1471143848 200 dbSNP
rs926685333 202 dbSNP
rs1406638732 205 dbSNP
rs1386758719 210 dbSNP
rs1417437565 213 dbSNP
rs1300711659 214 dbSNP
rs1027486690 230 dbSNP
rs938048044 242 dbSNP
rs992152954 247 dbSNP
rs116604523 248 dbSNP
rs1459639075 271 dbSNP
rs929251135 274 dbSNP
rs577372900 275 dbSNP
rs965715863 285 dbSNP
rs541335948 292 dbSNP
rs1254337157 293 dbSNP
rs560011461 294 dbSNP
rs941836213 298 dbSNP
rs1460720038 301 dbSNP
rs1263486422 303 dbSNP
rs1225088712 322 dbSNP
rs1316045783 328 dbSNP
rs529642261 336 dbSNP
rs1280156765 340 dbSNP
rs1038794467 349 dbSNP
rs1376264132 354 dbSNP
rs900259981 357 dbSNP
rs1451402594 358 dbSNP
rs968188871 372 dbSNP
rs1339160607 376 dbSNP
rs760872340 380 dbSNP
rs997616303 390 dbSNP
rs1396498627 395 dbSNP
rs1029985588 398 dbSNP
rs891431595 403 dbSNP
rs1317414032 404 dbSNP
rs1009823980 410 dbSNP
rs1021183342 414 dbSNP
rs968241136 417 dbSNP
rs1360524362 421 dbSNP
rs979607079 427 dbSNP
rs1001029367 430 dbSNP
rs1272209840 432 dbSNP
rs1033786354 435 dbSNP
rs959469691 444 dbSNP
rs1340892278 447 dbSNP
rs992621697 449 dbSNP
rs1244571172 461 dbSNP
rs538463435 463 dbSNP
rs992402794 476 dbSNP
rs1445026546 478 dbSNP
rs917925747 479 dbSNP
rs748514578 481 dbSNP
rs950739465 499 dbSNP
rs983341225 504 dbSNP
rs909127327 515 dbSNP
rs1389169306 516 dbSNP
rs941908396 518 dbSNP
rs150732274 521 dbSNP
rs1287528074 526 dbSNP
rs1439441154 527 dbSNP
rs1037525984 529 dbSNP
rs776636273 539 dbSNP
rs931377468 542 dbSNP
rs1182479103 543 dbSNP
rs933098130 549 dbSNP
rs1051910448 566 dbSNP
rs888933003 568 dbSNP
rs184247347 576 dbSNP
rs765046229 579 dbSNP
rs1237441468 580 dbSNP
rs901512375 583 dbSNP
rs1042699517 587 dbSNP
rs1020572678 598 dbSNP
rs904085448 601 dbSNP
rs967803008 602 dbSNP
rs1001061700 603 dbSNP
rs545965759 605 dbSNP
rs530481784 609 dbSNP
rs1400302285 616 dbSNP
rs959779851 621 dbSNP
rs1158987762 623 dbSNP
rs1419430535 630 dbSNP
rs992829679 650 dbSNP
rs1013676935 654 dbSNP
rs1025449183 661 dbSNP
rs775467896 667 dbSNP
rs1400291423 670 dbSNP
rs1212994311 675 dbSNP
rs1316021250 681 dbSNP
rs972763247 682 dbSNP
rs1444654149 689 dbSNP
rs1225902341 700 dbSNP
rs139103347 704 dbSNP
rs931408474 704 dbSNP
rs189352168 707 dbSNP
rs1224612649 709 dbSNP
rs1347505174 712 dbSNP
rs1343251867 719 dbSNP
rs1296468722 721 dbSNP
rs1317305406 731 dbSNP
rs75592051 733 dbSNP
rs910398622 735 dbSNP
rs974603689 736 dbSNP
rs559467921 738 dbSNP
rs1282172722 742 dbSNP
rs921790341 743 dbSNP
rs1402242912 760 dbSNP
rs1426882261 772 dbSNP
rs149815287 784 dbSNP
rs1480745587 788 dbSNP
rs1040695138 791 dbSNP
rs901796767 802 dbSNP
rs1485257457 810 dbSNP
rs1215028166 814 dbSNP
rs1242342834 818 dbSNP
rs1217425777 819 dbSNP
rs1460280774 824 dbSNP
rs1262870874 828 dbSNP
rs1204681573 841 dbSNP
rs552992018 844 dbSNP
rs1326349714 845 dbSNP
rs1294050864 850 dbSNP
rs1214063751 852 dbSNP
rs1362675971 863 dbSNP
rs763970310 865 dbSNP
rs1042063449 867 dbSNP
rs1034526263 871 dbSNP
rs1257331138 879 dbSNP
rs1456438951 880 dbSNP
rs79702942 888 dbSNP
rs912969519 889 dbSNP
rs1427423192 890 dbSNP
rs945715809 897 dbSNP
rs1419550669 906 dbSNP
rs193077856 908 dbSNP
rs145806793 909 dbSNP
rs1242122019 912 dbSNP
rs1204781661 914 dbSNP
rs537497370 915 dbSNP
rs1308184874 924 dbSNP
rs574840696 924 dbSNP
rs972962350 924 dbSNP
rs1171917943 929 dbSNP
rs559118090 931 dbSNP
rs1382379715 935 dbSNP
rs577333447 939 dbSNP
rs952660846 944 dbSNP
rs985550421 947 dbSNP
rs756900487 949 dbSNP
rs895326653 950 dbSNP
rs760924647 960 dbSNP
rs1406964755 961 dbSNP
rs767288556 966 dbSNP
rs541646041 967 dbSNP
rs886507565 972 dbSNP
rs1422207474 975 dbSNP
rs1332453057 978 dbSNP
rs572607709 979 dbSNP
rs376777063 980 dbSNP
rs1446840961 987 dbSNP
rs923083131 989 dbSNP
rs1176954515 999 dbSNP
rs1277371793 1006 dbSNP
rs139721399 1008 dbSNP
rs1220441839 1010 dbSNP
rs1358737704 1012 dbSNP
rs1292800457 1018 dbSNP
rs1248386725 1022 dbSNP
rs1225295133 1023 dbSNP
rs1390585862 1024 dbSNP
rs542126829 1024 dbSNP
rs544604288 1032 dbSNP
rs1309699960 1036 dbSNP
rs1402569710 1041 dbSNP
rs1364349434 1048 dbSNP
rs1163859542 1053 dbSNP
rs184664116 1063 dbSNP
rs1361683525 1064 dbSNP
rs1029315789 1068 dbSNP
rs1420043310 1080 dbSNP
rs1197824359 1084 dbSNP
rs954606456 1085 dbSNP
rs1343675862 1090 dbSNP
rs1224782343 1094 dbSNP
rs1198292441 1097 dbSNP
rs903539266 1098 dbSNP
rs530445889 1099 dbSNP
rs1194822995 1109 dbSNP
rs913007248 1110 dbSNP
rs936304780 1111 dbSNP
rs112724571 1112 dbSNP
rs1290157998 1112 dbSNP
rs1303282989 1112 dbSNP
rs545456681 1112 dbSNP
rs866143172 1113 dbSNP
rs978482011 1117 dbSNP
rs925610429 1127 dbSNP
rs1179217634 1129 dbSNP
rs1287859879 1132 dbSNP
rs1454646761 1134 dbSNP
rs1365860564 1143 dbSNP
rs1378217724 1144 dbSNP
rs1054717390 1145 dbSNP
rs1465595496 1155 dbSNP
rs936957866 1157 dbSNP
rs1055415334 1161 dbSNP
rs1400891634 1168 dbSNP
rs1261310110 1169 dbSNP
rs1205888354 1172 dbSNP
rs895386952 1177 dbSNP
rs575177402 1184 dbSNP
rs528248479 1185 dbSNP
rs544525559 1193 dbSNP
rs886581325 1194 dbSNP
rs1234786127 1195 dbSNP
rs1283860048 1201 dbSNP
rs1294436509 1221 dbSNP
rs748666406 1232 dbSNP
rs1004942429 1245 dbSNP
rs1390347093 1247 dbSNP
rs1230399909 1260 dbSNP
rs1469603194 1262 dbSNP
rs1407562401 1270 dbSNP
rs1262031366 1288 dbSNP
rs1016267732 1289 dbSNP
rs1025165855 1291 dbSNP
rs1193948721 1292 dbSNP
rs1430569105 1294 dbSNP
rs897291269 1306 dbSNP
rs758961018 1307 dbSNP
rs139323585 1310 dbSNP
rs1460654589 1310 dbSNP
rs1202063912 1321 dbSNP
rs189077051 1325 dbSNP
rs1250310441 1326 dbSNP
rs1227495608 1328 dbSNP
rs1202118022 1329 dbSNP
rs1366992324 1330 dbSNP
rs561828244 1332 dbSNP
rs377401559 1333 dbSNP
rs144505457 1337 dbSNP
rs1196815389 1338 dbSNP
rs1365624514 1341 dbSNP
rs560550114 1345 dbSNP
rs1158275492 1347 dbSNP
rs1336750970 1349 dbSNP
rs965517814 1361 dbSNP
rs146647738 1366 dbSNP
rs181530978 1371 dbSNP
rs987374782 1372 dbSNP
rs1431700867 1378 dbSNP
rs765136371 1381 dbSNP
rs540054396 1391 dbSNP
rs945179780 1421 dbSNP
rs1385032630 1422 dbSNP
rs1237799593 1425 dbSNP
rs967163388 1427 dbSNP
rs537458258 1428 dbSNP
rs977983787 1435 dbSNP
rs76769395 1436 dbSNP
rs1343598343 1437 dbSNP
rs925245004 1438 dbSNP
rs925686173 1440 dbSNP
rs1359664968 1443 dbSNP
rs570952564 1444 dbSNP
rs1440451689 1448 dbSNP
rs78778023 1450 dbSNP
rs1306614614 1454 dbSNP
rs1411753596 1458 dbSNP
rs916868014 1459 dbSNP
rs1225145295 1464 dbSNP
rs1416201259 1465 dbSNP
rs764845812 1467 dbSNP
rs1266451783 1474 dbSNP
rs916215643 1478 dbSNP
rs949183010 1498 dbSNP
rs949682150 1500 dbSNP
rs553490633 1511 dbSNP
rs1266197631 1520 dbSNP
rs1046541480 1521 dbSNP
rs1046621534 1523 dbSNP
rs758111240 1523 dbSNP
rs897334696 1524 dbSNP
rs141177596 1527 dbSNP
rs1440409005 1528 dbSNP
rs1280668159 1531 dbSNP
rs940854495 1531 dbSNP
rs1178167107 1538 dbSNP
rs1230734329 1560 dbSNP
rs1378669052 1562 dbSNP
rs769898885 1563 dbSNP
rs1405617449 1568 dbSNP
rs1037789157 1572 dbSNP
rs1165159961 1582 dbSNP
rs1316414258 1584 dbSNP
rs1349122582 1592 dbSNP
rs888733185 1593 dbSNP
rs1159583579 1597 dbSNP
rs1456269085 1608 dbSNP
rs1427094381 1612 dbSNP
rs1478031143 1614 dbSNP
rs899237645 1614 dbSNP
rs1007134187 1616 dbSNP
rs535718280 1635 dbSNP
rs1446819067 1637 dbSNP
rs1401015269 1644 dbSNP
rs1210948432 1645 dbSNP
rs1322108087 1646 dbSNP
rs1018297933 1647 dbSNP
rs144991547 1653 dbSNP
rs1050868292 1663 dbSNP
rs1268663062 1667 dbSNP
rs998289481 1676 dbSNP
rs1328734188 1680 dbSNP
rs1458610625 1691 dbSNP
rs574876404 1705 dbSNP
rs1384512414 1708 dbSNP
rs890436405 1720 dbSNP
rs1009231003 1721 dbSNP
rs1426611420 1727 dbSNP
rs1184226325 1729 dbSNP
rs1020177737 1740 dbSNP
rs1020750459 1744 dbSNP
rs967240380 1750 dbSNP
rs1263079123 1757 dbSNP
rs762659526 1760 dbSNP
rs1314422302 1766 dbSNP
rs73058403 1775 dbSNP
rs1243174268 1778 dbSNP
rs1214046560 1780 dbSNP
rs75921134 1787 dbSNP
rs569949989 1789 dbSNP
rs958688825 1790 dbSNP
rs991226156 1793 dbSNP
rs1437022773 1805 dbSNP
rs925105178 1807 dbSNP
rs115184109 1814 dbSNP
rs151267103 1817 dbSNP
rs761720134 1820 dbSNP
rs1167779382 1821 dbSNP
rs916260374 1827 dbSNP
rs368968409 1830 dbSNP
rs796774596 1830 dbSNP
rs879164025 1830 dbSNP
rs949036651 1831 dbSNP
rs1046149547 1837 dbSNP
rs1484556567 1838 dbSNP
rs1231665245 1850 dbSNP
rs918378800 1853 dbSNP
rs538861627 1854 dbSNP
rs982804932 1860 dbSNP
rs186401508 1861 dbSNP
rs188564504 1874 dbSNP
rs929701904 1879 dbSNP
rs1358956067 1884 dbSNP
rs1182669581 1889 dbSNP
rs1228661945 1896 dbSNP
rs1048619774 1916 dbSNP
rs1381335480 1916 dbSNP
rs767235314 1921 dbSNP
rs1370585118 1926 dbSNP
rs888596232 1934 dbSNP
rs940885844 1937 dbSNP
rs750056759 1945 dbSNP
rs1384201962 1947 dbSNP
rs1040327321 1949 dbSNP
rs1425854255 1951 dbSNP
rs1172354126 1955 dbSNP
rs181606612 1956 dbSNP
rs932075012 1957 dbSNP
rs1020278081 1958 dbSNP
rs1167855812 1960 dbSNP
rs1254122923 1974 dbSNP
rs751232614 1974 dbSNP
rs1050492163 1983 dbSNP
rs550861789 1984 dbSNP
rs1008893161 1987 dbSNP
rs1041697512 1998 dbSNP
rs957838979 2008 dbSNP
rs1394646740 2011 dbSNP
rs1280548850 2015 dbSNP
rs1319155819 2019 dbSNP
rs1351002547 2027 dbSNP
rs562806985 2028 dbSNP
rs1486688153 2032 dbSNP
rs552589679 2035 dbSNP
rs916443808 2039 dbSNP
rs1000061409 2049 dbSNP
rs1293692049 2061 dbSNP
rs989898096 2063 dbSNP
rs1032858529 2068 dbSNP
rs1343761474 2075 dbSNP
rs527808305 2075 dbSNP
rs780789505 2075 dbSNP
rs958543015 2076 dbSNP
rs1237116192 2079 dbSNP
rs918241446 2080 dbSNP
rs1480114057 2081 dbSNP
rs545973213 2082 dbSNP
rs759456564 2082 dbSNP
rs1258789098 2083 dbSNP
rs74969153 2084 dbSNP
rs570766142 2085 dbSNP
rs1269866240 2086 dbSNP
rs1263658986 2088 dbSNP
rs1329953269 2089 dbSNP
rs1477431390 2096 dbSNP
rs983846408 2096 dbSNP
rs1388191301 2097 dbSNP
rs1191419439 2105 dbSNP
rs1430715226 2108 dbSNP
rs1414527293 2111 dbSNP
rs1359401542 2114 dbSNP
rs1174823023 2116 dbSNP
rs1357053981 2118 dbSNP
rs753354284 2120 dbSNP
rs111752370 2121 dbSNP
rs1391476437 2121 dbSNP
rs1300398258 2132 dbSNP
rs1013084131 2135 dbSNP
rs1024024474 2141 dbSNP
rs1399873107 2146 dbSNP
rs910061049 2148 dbSNP
rs942825519 2159 dbSNP
rs1039873065 2162 dbSNP
rs1465131946 2164 dbSNP
rs758834515 2167 dbSNP
rs1249841553 2181 dbSNP
rs1201644742 2182 dbSNP
rs1344176586 2190 dbSNP
rs1219857305 2198 dbSNP
rs1256125012 2213 dbSNP
rs934248045 2213 dbSNP
rs1278063180 2219 dbSNP
rs150436665 2223 dbSNP
rs1296333611 2227 dbSNP
rs903169670 2233 dbSNP
rs1335359787 2236 dbSNP
rs1286380300 2238 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccccaccccUGUCUCCGAa 5'
                     | ||||||| 
Target 5' ----------aAAAGAGGCUg 3'
1 - 11
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000295658.4 | 3UTR | AAAAGAGGCUGGAAAUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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