pre-miRNA Information
pre-miRNA hsa-mir-3152   
Genomic Coordinates chr9: 18573306 - 18573379
Description Homo sapiens miR-3152 stem-loop
Comment Berezikov et al. proposed this sequence as a miRNA candidate based on the RAKE method .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3152-5p
Sequence 11| AUUGCCUCUGUUCUAACACAAG |32
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1019691326 2 dbSNP
rs1282676806 8 dbSNP
rs762305650 11 dbSNP
rs1364318615 12 dbSNP
rs556364307 18 dbSNP
rs1002755159 19 dbSNP
rs1238555909 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TUBGCP5   
Synonyms GCP5
Description tubulin gamma complex associated protein 5
Transcript NM_052903   
Other Transcripts NM_001102610   
Expression
Putative miRNA Targets on TUBGCP5
3'UTR of TUBGCP5
(miRNA target sites are highlighted)
>TUBGCP5|NM_052903|3'UTR
   1 ATGTCTTCAGCGTAATAAATATCTCCGACTTTGTCATCATACATGTACATTTCCACCATGTGCAGCTGAAAAGTGAAAAT
  81 ATTTTTATTTTGGTTTATTTGTAAAACTTGTCCACAGTCAGCCTGGCACAGTCGCTCATGCCTCTAATCCCAGCACGATG
 161 GGAGGCCAAGACAGGCAGATCACTTGAGCCCAGGAGTTTGAGGCCAGCCTGGGCAACATGGTGAAACCCGGTGTCTACCA
 241 AAAATACAAAATGTATCCAGACATGGTGGTGTGTACCTGTAGTCCCAGCTACTCAGGAGGCAAAGATGGGAGGATTACTT
 321 GAGCCCAGGAGGTCAAGGCTACAGTGAGCCATGATTGCACTACTGCAGTGCAACCTGGGTGACAGAGTGAGACCCTGACT
 401 CAGAAAGAACCACTTGCCCACAGTCCAGACAGATGGATTGTAGGTGGGTTTTCTGGAGATTAGTAGATACTGTATAGAGT
 481 TGTATACATAAAATTGTGTCAGTAGTACAAAGTGTATATAGGCTGTTTACTCTTACATTTCCTACTGTAAGATACAGATT
 561 TATGGTACTGATACCTTTAAATTATATCATATTTTGAAAATGTAATTACTGATATTCAAAATAAATTAAAGGACTTAAAA
 641 TCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
 721 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaACACA-----AUC----UUG------UCUCCGUUa 5'
            |||||     |||    |:|      :||||||| 
Target 5' ggTGTGTACCTGTAGTCCCAGCTACTCAGGAGGCAAa 3'
268 - 304 144.00 -17.10
2
miRNA  3' gaacacAAU---CUUG---UCUCC-GUUa 5'
                |||   ||:|   :|||| ||| 
Target 5' ggaggaTTACTTGAGCCCAGGAGGTCAAg 3'
309 - 337 116.00 -10.56
3
miRNA  3' gaacacaauCUUGUCUCCGUUa 5'
                   ||  :||||| | 
Target 5' tcccagcacGATGGGAGGCCAa 3'
148 - 169 113.00 -7.20
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1348131481 3 dbSNP
rs1173094735 6 dbSNP
rs146068854 11 dbSNP
rs747302187 12 dbSNP
rs189635431 14 dbSNP
rs1359564817 17 dbSNP
rs746032535 17 dbSNP
rs1186211555 20 dbSNP
rs1416516973 20 dbSNP
rs1338452848 22 dbSNP
rs1459190031 23 dbSNP
rs770148693 26 dbSNP
rs775712179 27 dbSNP
rs1400084513 29 dbSNP
rs1434014115 30 dbSNP
rs766351220 31 dbSNP
rs1279633783 33 dbSNP
rs751065402 37 dbSNP
rs1218968116 38 dbSNP
rs763917429 41 dbSNP
rs774388837 43 dbSNP
rs199797412 44 dbSNP
rs376915189 46 dbSNP
rs375923257 48 dbSNP
rs1324602810 49 dbSNP
rs1371047771 52 dbSNP
rs1314359270 57 dbSNP
rs953177621 59 dbSNP
rs770575718 62 dbSNP
rs1195954268 63 dbSNP
rs1245155551 66 dbSNP
rs1046860 77 dbSNP
rs533553465 88 dbSNP
rs1425585928 97 dbSNP
rs1386684499 106 dbSNP
rs941049224 110 dbSNP
rs1359837707 117 dbSNP
rs751952207 118 dbSNP
rs1319750232 129 dbSNP
rs928923766 133 dbSNP
rs938957959 134 dbSNP
rs982441288 137 dbSNP
rs181113881 149 dbSNP
rs1383280689 152 dbSNP
rs34956552 153 dbSNP
rs780756319 156 dbSNP
rs759383631 157 dbSNP
rs1282352593 158 dbSNP
rs1287780882 161 dbSNP
rs916115498 162 dbSNP
rs1199842584 163 dbSNP
rs1248674868 165 dbSNP
rs922902716 168 dbSNP
rs549902012 172 dbSNP
rs1352823174 183 dbSNP
rs747694143 194 dbSNP
rs1205186100 199 dbSNP
rs1160278087 200 dbSNP
rs1387938057 205 dbSNP
rs1404316841 218 dbSNP
rs529895747 229 dbSNP
rs569760113 230 dbSNP
rs1205186544 232 dbSNP
rs1244051266 245 dbSNP
rs1309033355 261 dbSNP
rs1378173106 263 dbSNP
rs548126431 264 dbSNP
rs1241784118 266 dbSNP
rs1283009878 266 dbSNP
rs967405054 271 dbSNP
rs57763913 284 dbSNP
rs903564711 295 dbSNP
rs7176295 305 dbSNP
rs377084293 307 dbSNP
rs1185939697 308 dbSNP
rs1237318560 310 dbSNP
rs1366034801 321 dbSNP
rs1052506903 324 dbSNP
rs1014278353 327 dbSNP
rs895789492 341 dbSNP
rs1366651862 345 dbSNP
rs530671408 355 dbSNP
rs1034977568 358 dbSNP
rs552076355 378 dbSNP
rs571275780 382 dbSNP
rs905028445 383 dbSNP
rs901490759 385 dbSNP
rs997869834 390 dbSNP
rs1330326985 395 dbSNP
rs1401473246 398 dbSNP
rs140174040 400 dbSNP
rs1337643045 417 dbSNP
rs1005319998 425 dbSNP
rs1245563128 426 dbSNP
rs886835367 430 dbSNP
rs778899850 434 dbSNP
rs1046866 442 dbSNP
rs1047234243 443 dbSNP
rs1316197149 446 dbSNP
rs547466545 447 dbSNP
rs933703166 461 dbSNP
rs368026312 464 dbSNP
rs1407580215 467 dbSNP
rs1332006534 468 dbSNP
rs1337433673 471 dbSNP
rs535707093 472 dbSNP
rs1239706942 473 dbSNP
rs185956190 484 dbSNP
rs1197355570 488 dbSNP
rs35834371 494 dbSNP
rs1253939826 495 dbSNP
rs190033257 508 dbSNP
rs1188216384 509 dbSNP
rs1016370944 514 dbSNP
rs1476591039 522 dbSNP
rs1224885980 523 dbSNP
rs1169431007 530 dbSNP
rs1263360592 530 dbSNP
rs1463805952 536 dbSNP
rs548 536 dbSNP
rs972157975 537 dbSNP
rs1036130874 542 dbSNP
rs942918332 544 dbSNP
rs1315432248 545 dbSNP
rs565663510 548 dbSNP
rs1399485190 551 dbSNP
rs554814880 554 dbSNP
rs978874712 563 dbSNP
rs916123461 572 dbSNP
rs967499600 581 dbSNP
rs913342742 592 dbSNP
rs1253138746 593 dbSNP
rs1253996488 593 dbSNP
rs1344104529 599 dbSNP
rs1211496774 610 dbSNP
rs1259532871 611 dbSNP
rs947563038 614 dbSNP
rs978868462 618 dbSNP
rs1261945326 631 dbSNP
rs925074585 631 dbSNP
rs143916755 642 dbSNP
rs1173579793 644 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaacacaaUCUUGUCUCCguua 5'
                  |||  :||||    
Target 5' -----caaAGAUGGGAGGauu- 3'
1 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_052903 | 3UTR | AAUGUAUCCAGACAUGGUGGUGUGUACCUGUAGUCCCAGCUACUCAGGAGGCAAAGAUGGGAGGAUUACUUGAGCCCAGGAGGUCAAGGCUACAGUGAGCCAUGAUUGCACUACUGCAGUGCAACCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_052903 | 3UTR | GUGGUGUGUACCUGUAGUCCCAGCUACUCAGGAGGCAAAGAUGGGAGGAUUACUUGAGCCCAGGAGGUCAAGGCUACAGUGAGCCAUGAUUGCACUACUGCAGUGCAACCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_052903 | 3UTR | AGUCCCAGCUACUCAGGAGGCAAAGAUGGGAGGAUUACUUGAGCCCAGGAGGUCAAGGCUACAGUGAGCCAUGAUUGCACUACUGCAGUGCAACCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_052903 | 3UTR | CAGCUACUCAGGAGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_052903 | 3UTR | AUGGUGGUGUGUACCUGUAGUCCCAGCUACUCAGGAGGCAAAGAUGGGAGGAUUACUUGAGCCCAGGAGGUCAAGGCUACAGUGAGCCAUGAUUGCACUACUGCAGUGCAACCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000283645.4 | 3UTR | CAAAGAUGGGAGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
75 hsa-miR-3152-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092535 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT461731 NDUFA2 NADH:ubiquinone oxidoreductase subunit A2 2 2
MIRT468456 SET SET nuclear proto-oncogene 2 2
MIRT482192 AHR aryl hydrocarbon receptor 2 2
MIRT507923 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT512208 C18orf25 chromosome 18 open reading frame 25 2 6
MIRT526238 STARD4 StAR related lipid transfer domain containing 4 2 2
MIRT536131 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT536280 LIMA1 LIM domain and actin binding 1 2 2
MIRT544251 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT548054 GOLGA7 golgin A7 2 2
MIRT563443 ISCA1 iron-sulfur cluster assembly 1 2 2
MIRT565643 SIX4 SIX homeobox 4 2 2
MIRT614870 PDE12 phosphodiesterase 12 2 2
MIRT614923 MARCH6 membrane associated ring-CH-type finger 6 2 2
MIRT615793 FAM124A family with sequence similarity 124 member A 2 2
MIRT618557 VLDLR very low density lipoprotein receptor 2 2
MIRT622147 SORBS2 sorbin and SH3 domain containing 2 2 2
MIRT622390 RSBN1 round spermatid basic protein 1 2 2
MIRT624185 DDX19B DEAD-box helicase 19B 2 2
MIRT624448 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT625340 TAPBP TAP binding protein 2 2
MIRT625370 IRGQ immunity related GTPase Q 2 2
MIRT627276 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT627746 RAD54L2 RAD54 like 2 2 2
MIRT629578 RFC2 replication factor C subunit 2 2 4
MIRT630537 LGALS8 galectin 8 2 4
MIRT630559 C3orf36 chromosome 3 open reading frame 36 2 4
MIRT630568 SOWAHA sosondowah ankyrin repeat domain family member A 2 4
MIRT630763 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT635424 LRP10 LDL receptor related protein 10 2 2
MIRT636011 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2 2
MIRT636337 PHAX phosphorylated adaptor for RNA export 2 2
MIRT638413 POU3F2 POU class 3 homeobox 2 2 2
MIRT639358 INIP INTS3 and NABP interacting protein 2 2
MIRT642124 DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A 2 4
MIRT642828 KIAA0319 KIAA0319 2 2
MIRT644017 NUCB1 nucleobindin 1 2 2
MIRT644038 WWC2 WW and C2 domain containing 2 2 2
MIRT644153 GIN1 gypsy retrotransposon integrase 1 2 2
MIRT644649 SNX9 sorting nexin 9 2 2
MIRT645798 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT647633 FAIM2 Fas apoptotic inhibitory molecule 2 2 2
MIRT648528 KIAA1143 KIAA1143 2 2
MIRT648851 PDLIM3 PDZ and LIM domain 3 2 2
MIRT648880 TUBGCP5 tubulin gamma complex associated protein 5 2 2
MIRT650777 TNFRSF10A TNF receptor superfamily member 10a 2 2
MIRT654200 RNF19B ring finger protein 19B 2 2
MIRT654508 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT655249 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT656089 MTA3 metastasis associated 1 family member 3 2 2
MIRT656599 LRRC55 leucine rich repeat containing 55 2 2
MIRT659194 CYBB cytochrome b-245 beta chain 2 2
MIRT660000 C1orf115 chromosome 1 open reading frame 115 2 4
MIRT661715 KLF8 Kruppel like factor 8 2 2
MIRT661813 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT668360 FGD4 FYVE, RhoGEF and PH domain containing 4 2 2
MIRT679734 CABP4 calcium binding protein 4 2 2
MIRT708616 NUDT18 nudix hydrolase 18 2 2
MIRT709034 TROVE2 TROVE domain family member 2 2 2
MIRT709573 DMGDH dimethylglycine dehydrogenase 2 2
MIRT709665 AJAP1 adherens junctions associated protein 1 2 2
MIRT709874 TRAF1 TNF receptor associated factor 1 2 2
MIRT710821 NLRP12 NLR family pyrin domain containing 12 2 2
MIRT710883 PARL presenilin associated rhomboid like 2 2
MIRT711547 LCAT lecithin-cholesterol acyltransferase 2 2
MIRT712017 STX1B syntaxin 1B 2 2
MIRT713058 BLVRA biliverdin reductase A 2 2
MIRT713129 THRB thyroid hormone receptor beta 2 2
MIRT713878 MOB3A MOB kinase activator 3A 2 2
MIRT714154 NXPH3 neurexophilin 3 2 2
MIRT719755 FLYWCH1 FLYWCH-type zinc finger 1 2 2
MIRT720213 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT722728 BRMS1 breast cancer metastasis suppressor 1 2 2
MIRT725652 ABI2 abl interactor 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)

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