pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GTF3C3   
Synonyms TFIIIC102, TFIIICgamma, TFiiiC2-102
Description general transcription factor IIIC subunit 3
Transcript NM_012086   
Expression
Putative miRNA Targets on GTF3C3
3'UTR of GTF3C3
(miRNA target sites are highlighted)
>GTF3C3|NM_012086|3'UTR
   1 AGCACCGCAACTGAGAACAGAGCAATGGCAGCTGCTGTGTGAGGACCAGTGTCTTCTGTCTCAGGGCTTATTATTTGTAA
  81 CTCCAAAATAGAAATGACAATTTCAGAATTACCTAACAAACAGTGTATTTATTTTTAATATGTGATAATGATCTTGTGGT
 161 ATATATGCAAAATTATTCCTACAAAAATTTGTATATTGGTCTGTCATTTTCCTTTCACATTCTATAGTGAATTGTTCCCA
 241 ATGTTGAAATGGACGTGTAAGCCTTTGAGCTAGCTTGGAGTCGAATACACTATTTTTCACTCACACCATTTATTCATCTT
 321 TGTATTTAATACTATAGCTCTGTCAATATCACATGAGGCAGTTTTTCAAATACGTATAAACAGAGGTTGCTTATTATTAA
 401 AGGAAAGACAAAGTGGGACTCTTTATGATGTCATGACCATGATAACTAAGCACCTAAGAAAATTATTTAAAATAGTTATG
 481 TGGTAGGCAGAAAGACAAATAATTTAGTTTTTTACTTTTCACCAGCATGTATCTTAGCTACCTAAACTGAAACATGGGAG
 561 GCTGGGCTTAATTCAAAATATATTGCTCCAAGGCAAATAAAAAAATGCTTTATCTATATTTGTGGCTTTCTGATGAAAAA
 641 ATAGAGAAGAGCTTGTTCAATAACAGGACATGGTTTCCATTTCAAGATCACAAGTAATATAAGACTGGGCAAGTAGTACG
 721 TATGGAATAAAGGACATACTGCTGATTGATAAAGTAAAAAACTTTTTTTTTGTTTGTTTACTCATCTCCACTATTTATTA
 801 TATGTTCTTGAATTTAAGTTAACAGTACTTTTTAGATGATATACTGTTAGCTTAATAACAACTTTTTAGGGAAAAATAAA
 881 TGCTGTAATTAATGTGCACATGGGTTAGTAACACCCAGCCCAATTGTGGGAGGGAAACAAGTAGAGGCTTAGGATCAAAG
 961 AAATAAAATTGGGACTTATTAGAAATTCTTACCACTGTTTCTACTGTACACAAAACTTTCTAGTTGAGCAGAATTTGTAT
1041 GCAATAAGTAAATATATTGTATACTCCATGTGTATAATTTAAATGCATTTTATTTTTATAATTGAGGTTAACTGTTTCAC
1121 ATGCTTAATTTTTACTTTATGCCATTTATAGGTAATGGTAGAGGTAACTGAGATACAGTAATAAGTTAGACTTGTGTGTT
1201 GGAATTCTGTGGAACTGAGCATTCTGTGCTCCGAGTTTCTCTCTTAAATTAGCTCACTGGACTGTGGCTCCAGTGTCTAC
1281 TAAATAGCCGTGGAGGAAATAAGTCTCCCTAAGGGAAAAAAAAACCAGCTGATATTGTATAGTTTTGTTTAGCTTTTAAA
1361 ATCATAGCTTCCATTTGCTGAGTTTTTACTCTGCTACTGTATGCTAAGTATGGTGCTAAACACTTTGGATATGTTATCTC
1441 TGATTCTCTCAGGGAACTGCAAGGTAGTTATTATTGATATTGTCATCACCACTTTGTATCTAGAGATTAAATAGCATGTT
1521 CAAGATCACTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            |||  |  ||| ||||||| 
Target 5' ccCAATTG--TGGGAGGGAAAc 3'
919 - 938 156.00 -18.10
2
miRNA  3' cggUUCCCUUA--CCG------UCCCUUUa 5'
             :||| |||  | |      ||||||| 
Target 5' gtgGAGGAAATAAGTCTCCCTAAGGGAAAa 3'
1290 - 1319 147.00 -16.30
3
miRNA  3' cgguucccuuaccGUCCCUUUa 5'
                       :||||||| 
Target 5' aataacaacttttTAGGGAAAa 3'
854 - 875 141.00 -10.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13960606 7 COSMIC
COSN17261911 28 COSMIC
COSN30505609 37 COSMIC
COSN30151122 41 COSMIC
COSN30539739 56 COSMIC
COSN26603867 83 COSMIC
COSN30188642 86 COSMIC
COSN32166138 403 COSMIC
COSN21026542 686 COSMIC
COSN17654057 865 COSMIC
COSN9870872 1062 COSMIC
COSN17073225 1232 COSMIC
COSN18723469 1245 COSMIC
COSN22826953 1315 COSMIC
COSN21628280 1444 COSMIC
COSN16484976 1513 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1296522893 5 dbSNP
rs151048249 6 dbSNP
rs751872209 7 dbSNP
rs1352912769 9 dbSNP
rs764257822 10 dbSNP
rs763214588 11 dbSNP
rs1336485802 17 dbSNP
rs775518900 18 dbSNP
rs1441796196 19 dbSNP
rs769932002 20 dbSNP
rs994727880 25 dbSNP
rs1377456364 26 dbSNP
rs1313886880 27 dbSNP
rs1210165541 32 dbSNP
rs759381924 34 dbSNP
rs776573970 37 dbSNP
rs1161038355 38 dbSNP
rs760580807 38 dbSNP
rs199706533 42 dbSNP
rs1363918900 46 dbSNP
rs746781883 47 dbSNP
rs777731317 48 dbSNP
rs1187523679 55 dbSNP
rs562579272 57 dbSNP
rs1327126666 58 dbSNP
rs1390472557 58 dbSNP
rs1300024483 63 dbSNP
rs542696314 66 dbSNP
rs1171237248 73 dbSNP
rs1402059374 74 dbSNP
rs1415577151 75 dbSNP
rs1450728802 76 dbSNP
rs1336174026 77 dbSNP
rs1386558716 77 dbSNP
rs776112321 83 dbSNP
rs1321430568 89 dbSNP
rs1326556573 91 dbSNP
rs573600069 95 dbSNP
rs1005115706 96 dbSNP
rs1367683528 96 dbSNP
rs1229276416 100 dbSNP
rs1344138307 101 dbSNP
rs890333712 105 dbSNP
rs1264995871 109 dbSNP
rs1335829131 111 dbSNP
rs1051441005 113 dbSNP
rs1207597853 114 dbSNP
rs1248231716 118 dbSNP
rs1465990958 120 dbSNP
rs535533694 123 dbSNP
rs543186803 123 dbSNP
rs577855109 123 dbSNP
rs1491547715 124 dbSNP
rs995909080 127 dbSNP
rs574640024 128 dbSNP
rs1160030374 130 dbSNP
rs1456756021 130 dbSNP
rs1404232391 131 dbSNP
rs537623781 135 dbSNP
rs1013584594 136 dbSNP
rs774916245 137 dbSNP
rs894762348 141 dbSNP
rs560082212 142 dbSNP
rs1057480549 146 dbSNP
rs1460988778 147 dbSNP
rs1327053024 150 dbSNP
rs556330457 158 dbSNP
rs1053400188 160 dbSNP
rs886837155 164 dbSNP
rs376666213 166 dbSNP
rs904782919 168 dbSNP
rs1201529550 169 dbSNP
rs1170010914 176 dbSNP
rs1250187591 179 dbSNP
rs769030666 180 dbSNP
rs930933627 182 dbSNP
rs1042008126 183 dbSNP
rs538010840 193 dbSNP
rs1414302130 197 dbSNP
rs946205611 204 dbSNP
rs919589941 205 dbSNP
rs1242197054 210 dbSNP
rs1184556017 216 dbSNP
rs917449483 219 dbSNP
rs992899647 220 dbSNP
rs1304749498 227 dbSNP
rs1348506946 227 dbSNP
rs1409137261 228 dbSNP
rs182338613 231 dbSNP
rs1264472594 244 dbSNP
rs1356643372 247 dbSNP
rs942598127 254 dbSNP
rs927255164 255 dbSNP
rs987012774 260 dbSNP
rs557606096 262 dbSNP
rs1253371624 266 dbSNP
rs1370079111 268 dbSNP
rs1195748494 272 dbSNP
rs1186990450 275 dbSNP
rs1340076675 277 dbSNP
rs111749387 279 dbSNP
rs973409705 283 dbSNP
rs935178877 284 dbSNP
rs963444508 289 dbSNP
rs142968997 292 dbSNP
rs1243947493 293 dbSNP
rs1308555832 300 dbSNP
rs977477084 305 dbSNP
rs1393743917 306 dbSNP
rs1247740058 312 dbSNP
rs1311428433 312 dbSNP
rs1340633297 312 dbSNP
rs763624391 322 dbSNP
rs575056454 324 dbSNP
rs1358972583 329 dbSNP
rs1341895544 331 dbSNP
rs1206369174 332 dbSNP
rs555446057 333 dbSNP
rs1245201544 337 dbSNP
rs1199898415 346 dbSNP
rs149015531 347 dbSNP
rs983410579 351 dbSNP
rs1462777558 355 dbSNP
rs1326691011 356 dbSNP
rs954687258 359 dbSNP
rs1448611932 373 dbSNP
rs4380257 373 dbSNP
rs995856515 374 dbSNP
rs1035966988 383 dbSNP
rs867475218 386 dbSNP
rs1402282719 389 dbSNP
rs546957129 395 dbSNP
rs1384178292 397 dbSNP
rs1163853444 400 dbSNP
rs1364068306 400 dbSNP
rs1473946580 406 dbSNP
rs1229530422 408 dbSNP
rs1298223817 413 dbSNP
rs1310885740 413 dbSNP
rs1233174959 422 dbSNP
rs1257156441 423 dbSNP
rs887283667 425 dbSNP
rs1206946730 427 dbSNP
rs777837902 430 dbSNP
rs1465540778 438 dbSNP
rs1362428525 443 dbSNP
rs1186822309 444 dbSNP
rs1263601308 444 dbSNP
rs1181628090 447 dbSNP
rs1025361211 450 dbSNP
rs1429957937 456 dbSNP
rs995246295 463 dbSNP
rs1438887615 466 dbSNP
rs1254657574 473 dbSNP
rs1000933538 474 dbSNP
rs1220313859 475 dbSNP
rs1435364590 478 dbSNP
rs1290937748 479 dbSNP
rs1490217233 479 dbSNP
rs898271506 480 dbSNP
rs1211860712 503 dbSNP
rs1302546804 503 dbSNP
rs902217328 507 dbSNP
rs1042345346 508 dbSNP
rs1267591894 514 dbSNP
rs1277540002 520 dbSNP
rs1218195056 524 dbSNP
rs942396931 528 dbSNP
rs761493756 534 dbSNP
rs1190459732 535 dbSNP
rs1269446047 536 dbSNP
rs1481393918 540 dbSNP
rs1179299783 542 dbSNP
rs946349491 553 dbSNP
rs895958860 554 dbSNP
rs1057339117 561 dbSNP
rs937374920 564 dbSNP
rs1238119095 566 dbSNP
rs865978072 568 dbSNP
rs1347798523 571 dbSNP
rs1350996611 574 dbSNP
rs770371415 602 dbSNP
rs1457699775 606 dbSNP
rs891008514 606 dbSNP
rs1347867049 613 dbSNP
rs769856629 615 dbSNP
rs1288335289 616 dbSNP
rs1050975151 617 dbSNP
rs1225579692 617 dbSNP
rs1287969564 620 dbSNP
rs747238638 621 dbSNP
rs1321377656 626 dbSNP
rs1323734398 635 dbSNP
rs1292231178 637 dbSNP
rs769811735 640 dbSNP
rs745990233 642 dbSNP
rs142644999 644 dbSNP
rs1178482055 647 dbSNP
rs146840113 660 dbSNP
rs914686198 664 dbSNP
rs991875765 671 dbSNP
rs369894879 677 dbSNP
rs534526730 678 dbSNP
rs1394638866 687 dbSNP
rs191020400 689 dbSNP
rs907897708 695 dbSNP
rs1036321277 699 dbSNP
rs1445469848 704 dbSNP
rs1444410403 708 dbSNP
rs1282528835 710 dbSNP
rs551254814 715 dbSNP
rs1229112877 719 dbSNP
rs531129212 719 dbSNP
rs1167596543 720 dbSNP
rs1225950522 738 dbSNP
rs954666200 739 dbSNP
rs1438347301 746 dbSNP
rs562262306 749 dbSNP
rs974558450 750 dbSNP
rs1183818129 751 dbSNP
rs758510291 751 dbSNP
rs995697060 751 dbSNP
rs1386752169 754 dbSNP
rs964550555 756 dbSNP
rs1168378871 759 dbSNP
rs898212490 760 dbSNP
rs1032051185 761 dbSNP
rs1332205397 762 dbSNP
rs1358635529 763 dbSNP
rs1204284315 765 dbSNP
rs1000646201 766 dbSNP
rs966766775 768 dbSNP
rs1018034223 772 dbSNP
rs1216242770 772 dbSNP
rs1225839550 772 dbSNP
rs1276502206 772 dbSNP
rs1363348512 772 dbSNP
rs1329630397 776 dbSNP
rs1006932788 780 dbSNP
rs781450990 780 dbSNP
rs890800214 783 dbSNP
rs1244549640 790 dbSNP
rs1188247701 800 dbSNP
rs1463295919 800 dbSNP
rs549263835 800 dbSNP
rs1010882306 803 dbSNP
rs1425130614 805 dbSNP
rs781461448 818 dbSNP
rs1470331020 819 dbSNP
rs1178706226 820 dbSNP
rs1050756587 823 dbSNP
rs1319295324 823 dbSNP
rs1434665766 823 dbSNP
rs185769020 824 dbSNP
rs369652558 829 dbSNP
rs1438051192 834 dbSNP
rs1272982826 837 dbSNP
rs1043522671 839 dbSNP
rs1223555091 841 dbSNP
rs528965482 841 dbSNP
rs559917580 842 dbSNP
rs914614473 849 dbSNP
rs371665030 853 dbSNP
rs1204169197 859 dbSNP
rs1458054643 861 dbSNP
rs555401286 863 dbSNP
rs1374918149 865 dbSNP
rs1449065606 868 dbSNP
rs1174801837 869 dbSNP
rs752006141 884 dbSNP
rs1426543443 893 dbSNP
rs906052939 896 dbSNP
rs928618701 901 dbSNP
rs981467976 904 dbSNP
rs1474484919 907 dbSNP
rs1038178104 908 dbSNP
rs1428170196 914 dbSNP
rs951589018 938 dbSNP
rs1241692363 940 dbSNP
rs1387479655 941 dbSNP
rs1402184095 946 dbSNP
rs113063229 950 dbSNP
rs1344730289 953 dbSNP
rs907841872 954 dbSNP
rs1047723632 956 dbSNP
rs1465127289 958 dbSNP
rs974207146 960 dbSNP
rs1201597873 964 dbSNP
rs1348078244 964 dbSNP
rs1237751637 966 dbSNP
rs376729316 968 dbSNP
rs535546629 968 dbSNP
rs933207822 968 dbSNP
rs778844711 978 dbSNP
rs962918417 979 dbSNP
rs1208390976 987 dbSNP
rs923185449 992 dbSNP
rs1336910404 993 dbSNP
rs974672420 997 dbSNP
rs1250300646 998 dbSNP
rs1472294096 1001 dbSNP
rs964498002 1001 dbSNP
rs1269170290 1012 dbSNP
rs1365718713 1016 dbSNP
rs1018400802 1019 dbSNP
rs1161188087 1020 dbSNP
rs77205562 1023 dbSNP
rs1366982187 1040 dbSNP
rs577533798 1042 dbSNP
rs1425135974 1044 dbSNP
rs1304841139 1053 dbSNP
rs758974119 1055 dbSNP
rs564051456 1056 dbSNP
rs753677793 1059 dbSNP
rs1328981729 1061 dbSNP
rs1337091747 1068 dbSNP
rs544057380 1069 dbSNP
rs1574424 1072 dbSNP
rs1360580935 1075 dbSNP
rs1408221930 1081 dbSNP
rs1248691149 1083 dbSNP
rs1013244274 1086 dbSNP
rs960399657 1093 dbSNP
rs1196390462 1098 dbSNP
rs368611037 1107 dbSNP
rs1440830425 1114 dbSNP
rs1043638239 1116 dbSNP
rs1169381173 1117 dbSNP
rs1444992346 1118 dbSNP
rs1165262408 1122 dbSNP
rs1451541079 1122 dbSNP
rs752678837 1123 dbSNP
rs1167931460 1131 dbSNP
rs1461423835 1131 dbSNP
rs894983422 1135 dbSNP
rs1393834376 1136 dbSNP
rs1335649156 1140 dbSNP
rs141666878 1140 dbSNP
rs1055409355 1142 dbSNP
rs1295871297 1145 dbSNP
rs1307371261 1154 dbSNP
rs1228781764 1155 dbSNP
rs1001813837 1164 dbSNP
rs756884167 1174 dbSNP
rs1203164152 1176 dbSNP
rs1243921502 1179 dbSNP
rs767017484 1182 dbSNP
rs1462848371 1183 dbSNP
rs1185130815 1185 dbSNP
rs1259414873 1186 dbSNP
rs906000489 1187 dbSNP
rs1427762908 1190 dbSNP
rs1037890586 1191 dbSNP
rs1237939451 1194 dbSNP
rs937435780 1195 dbSNP
rs1467731467 1200 dbSNP
rs1175128820 1201 dbSNP
rs1406272893 1203 dbSNP
rs200942296 1203 dbSNP
rs1318206402 1216 dbSNP
rs1361697619 1221 dbSNP
rs1383162588 1224 dbSNP
rs139847157 1227 dbSNP
rs111774926 1229 dbSNP
rs886530906 1232 dbSNP
rs1048314507 1233 dbSNP
rs1435504613 1241 dbSNP
rs1325857049 1245 dbSNP
rs933322614 1248 dbSNP
rs923299946 1255 dbSNP
rs763843002 1268 dbSNP
rs1260403941 1279 dbSNP
rs974354537 1288 dbSNP
rs573266761 1289 dbSNP
rs550697514 1290 dbSNP
rs1245635590 1295 dbSNP
rs1197999569 1299 dbSNP
rs1380365802 1307 dbSNP
rs1481172514 1311 dbSNP
rs1305039213 1313 dbSNP
rs1440641599 1314 dbSNP
rs539829187 1316 dbSNP
rs986062445 1316 dbSNP
rs1454583218 1323 dbSNP
rs145972256 1324 dbSNP
rs1284547986 1325 dbSNP
rs979292735 1325 dbSNP
rs1226705101 1327 dbSNP
rs34099921 1330 dbSNP
rs753331343 1335 dbSNP
rs1383579182 1336 dbSNP
rs1163205139 1339 dbSNP
rs1262286785 1342 dbSNP
rs1489816156 1347 dbSNP
rs966358426 1348 dbSNP
rs1269574349 1350 dbSNP
rs1022131164 1351 dbSNP
rs551341028 1365 dbSNP
rs1422971424 1369 dbSNP
rs1414266703 1375 dbSNP
rs1174998897 1387 dbSNP
rs1183435972 1390 dbSNP
rs775374190 1396 dbSNP
rs1161664435 1397 dbSNP
rs1383761619 1400 dbSNP
rs1424503331 1406 dbSNP
rs183305920 1409 dbSNP
rs913648802 1416 dbSNP
rs1440060719 1418 dbSNP
rs1297683943 1421 dbSNP
rs1374249706 1423 dbSNP
rs1251038407 1426 dbSNP
rs565104073 1427 dbSNP
rs895090547 1427 dbSNP
rs1003803518 1433 dbSNP
rs1205201207 1435 dbSNP
rs1483762385 1438 dbSNP
rs991932094 1445 dbSNP
rs529633418 1448 dbSNP
rs762386603 1451 dbSNP
rs907254919 1452 dbSNP
rs1201745827 1453 dbSNP
rs1231828988 1462 dbSNP
rs1289065455 1467 dbSNP
rs568703434 1478 dbSNP
rs960347111 1480 dbSNP
rs76064107 1488 dbSNP
rs1178572563 1492 dbSNP
rs929921362 1499 dbSNP
rs1240932260 1505 dbSNP
rs1444339974 1506 dbSNP
rs1033357785 1510 dbSNP
rs897156930 1519 dbSNP
rs1164644459 1527 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccuuaccgUCCCUUUa 5'
                        ||||||| 
Target 5' -----------cuaAGGGAAAa 3'
1 - 11
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000263956.3 | 3UTR | CUAAGGGAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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