pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ITPKC   
Synonyms IP3-3KC, IP3KC
Description inositol-trisphosphate 3-kinase C
Transcript NM_025194   
Expression
Putative miRNA Targets on ITPKC
3'UTR of ITPKC
(miRNA target sites are highlighted)
>ITPKC|NM_025194|3'UTR
   1 GCTGCTCAGCCACCATCAGGTTAATTGGATGGCGCCAGTCTGGCTGGAGGAGCCCTGAGATGCCATGGGAGGCCTGAGGT
  81 TGGCCACGGGGGAGCTGGCCTCCAGGGACGGGAGAGATTGTGTCATGTGCCACACGAGACCAACGTGGAAAAGTCTGAAG
 161 GGCCTTGGGAGACCAGGTAGCACCTGGCCCCATCATGATGCAGGGGTTTTGGGGACCTGGAAGGAAGGTGATGAGGCAGT
 241 GAGTCAGAAAAACCAGAACGGGGTCCCCGGATCTGCCGGGAAGGCTTCTGAGGGGCTGCCCTGAGAGCATTCAGTTCACA
 321 TGTCACAGGGTATGGTGTGACAGGGTGCCTGTGGACACATGAATCACTTCTAACCTGCCTCCCTGTCAGCCTCCAGGCTG
 401 CCAGCTGGCTGAGGCCAGGGACTGGGTCAGGCTCATCTGTGGCGCCTCAGAGGGTCAGCATCATTGGTGAACAGATGCAG
 481 GCGCTGCTGGACCATCTGGGGAGAGTGACAGTCCATGTCTTCACCAGGGAGCCATTTGAGTGCTGAGCGACAAGAGGCTC
 561 AGAGGGCATGACCCCATGGGACTGGATGCGGCCTGAGGGCTGATACCGCTGGGCGGTATCCTGCCCTGCTGTGGCCCTGT
 641 GGGATCCTCCGTGTTCCTCGGCGGACTCTGCTGACCTCCTGCAGACCCAAACCACAGCCACATCCCAGCTTCTGTGCCAG
 721 CACTGTGACAGTACCTCGCTCCTCTGTGCACCAGATCCGGCCTCAGGACTTACACCTCCTGCCTGACCCCCAGGCTTCTC
 801 TCTCCTTTCTCCCAGCAAACTGCAGTGGCAGAAAGGAGGTTCAGAGGCTGGGAAAGTGGGCCTCCCCTTGCAACTCAGAG
 881 CTGCTGCACTCAGGAGGGCCCCATCCAATCCCGGGCCCCTGCAGGGAAAAGCGCTGGGTGTGTGTCAGAGGCGCAGGGTG
 961 GGTGGGGCTGCCAGCCAGGACCCTGGCCTGCAGCCTGATCCAAACCAAAGACTGTAGAACCCTGGGGTGTGGCTAACGGC
1041 CCCTCCAGCACCCATAGCCAGGTCTTCCTGGCCCTTGAGGCTGGGCTGGCGGACAGGCACCTACCTCTTCCTTAAGCTGA
1121 AGCTCCCACACTGTCTTCCAGGGCTGAGGAGATGCTCTCCTTTTCTACTGACCATCTTGATACTTATTTATACGAGAGGC
1201 AGTTGCTGGACGGGGTAGTACTGGGAAGCAGGAGGCAGAATGGCTCTGCTGAGCCTCCTACCCATGACAACACCCCAATA
1281 AACAGAACATTCAGAGCCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgguucccuuacCGUCCCUUUa 5'
                      ||||||||| 
Target 5' tcccgggcccctGCAGGGAAAa 3'
909 - 930 150.00 -18.70
2
miRNA  3' cggUUCCCUUA-----CCGUCCCUUUa 5'
             |||| ::|     ||| |||||| 
Target 5' agaAAGGAGGTTCAGAGGCTGGGAAAg 3'
830 - 856 131.00 -15.50
3
miRNA  3' cgGUUCCCUU-ACC----GUCCCUuua 5'
            |::||||: |||    ||||||   
Target 5' caCGGGGGAGCTGGCCTCCAGGGAcgg 3'
85 - 111 126.00 -21.92
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31488852 18 COSMIC
COSN30119236 35 COSMIC
COSN31589844 50 COSMIC
COSN20859944 264 COSMIC
COSN28814871 742 COSMIC
COSN31551286 887 COSMIC
COSN6668729 1028 COSMIC
COSN20093605 1136 COSMIC
COSN31572256 1194 COSMIC
COSN30175150 1202 COSMIC
COSN24040824 1239 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs200330367 5 dbSNP
rs1346009763 7 dbSNP
rs751734658 17 dbSNP
rs1344355745 18 dbSNP
rs1158552713 19 dbSNP
rs755223441 19 dbSNP
rs1398965735 20 dbSNP
rs781466180 21 dbSNP
rs577540935 26 dbSNP
rs372542875 34 dbSNP
rs778278782 35 dbSNP
rs769170172 36 dbSNP
rs749742819 37 dbSNP
rs1185488600 38 dbSNP
rs772087170 39 dbSNP
rs950492336 41 dbSNP
rs1477406374 45 dbSNP
rs1172716341 46 dbSNP
rs987317373 47 dbSNP
rs911747765 50 dbSNP
rs1334041014 66 dbSNP
rs1234496081 67 dbSNP
rs1339252406 80 dbSNP
rs1291897968 83 dbSNP
rs899369330 88 dbSNP
rs995644955 89 dbSNP
rs975068119 106 dbSNP
rs190954897 110 dbSNP
rs936670107 111 dbSNP
rs1326635543 118 dbSNP
rs1025419686 119 dbSNP
rs553569272 120 dbSNP
rs758522674 121 dbSNP
rs1162596102 123 dbSNP
rs1430019168 135 dbSNP
rs1262164823 136 dbSNP
rs1185528383 137 dbSNP
rs181995406 140 dbSNP
rs1199682797 144 dbSNP
rs1254383332 145 dbSNP
rs577044726 146 dbSNP
rs1271760057 149 dbSNP
rs563143578 149 dbSNP
rs969270193 153 dbSNP
rs1046553624 163 dbSNP
rs1243810185 167 dbSNP
rs186325489 170 dbSNP
rs1213080886 173 dbSNP
rs1002421203 174 dbSNP
rs1304345265 175 dbSNP
rs1440242955 184 dbSNP
rs530514569 184 dbSNP
rs1033913496 185 dbSNP
rs569397376 187 dbSNP
rs925091361 195 dbSNP
rs1393657442 196 dbSNP
rs1176972016 198 dbSNP
rs899451942 199 dbSNP
rs994443343 208 dbSNP
rs1365799560 212 dbSNP
rs1454589377 219 dbSNP
rs536830822 224 dbSNP
rs545741781 229 dbSNP
rs1172378694 231 dbSNP
rs369703591 240 dbSNP
rs796970943 240 dbSNP
rs773567523 243 dbSNP
rs1193730026 249 dbSNP
rs950487020 257 dbSNP
rs1251716570 260 dbSNP
rs564020782 261 dbSNP
rs936548163 262 dbSNP
rs1471233725 264 dbSNP
rs1338010867 269 dbSNP
rs761037353 270 dbSNP
rs190675206 271 dbSNP
rs1281231176 273 dbSNP
rs2290693 278 dbSNP
rs1051777323 279 dbSNP
rs925847743 286 dbSNP
rs79238753 290 dbSNP
rs1254025663 292 dbSNP
rs765729827 296 dbSNP
rs530141896 314 dbSNP
rs1204197374 315 dbSNP
rs1257391274 318 dbSNP
rs1407708027 320 dbSNP
rs1037979132 321 dbSNP
rs147023999 322 dbSNP
rs1173833241 327 dbSNP
rs1175581553 329 dbSNP
rs1375476668 331 dbSNP
rs569997514 334 dbSNP
rs1252860123 336 dbSNP
rs1420272495 355 dbSNP
rs755881159 363 dbSNP
rs1250414869 366 dbSNP
rs1175860296 375 dbSNP
rs1419888371 378 dbSNP
rs971709854 386 dbSNP
rs1486818671 391 dbSNP
rs1258521726 400 dbSNP
rs1198493314 404 dbSNP
rs1345958676 406 dbSNP
rs866416972 408 dbSNP
rs1262639508 426 dbSNP
rs1239847398 429 dbSNP
rs753196472 435 dbSNP
rs779737869 443 dbSNP
rs1481644528 445 dbSNP
rs1407800335 453 dbSNP
rs1177732392 465 dbSNP
rs1046774962 469 dbSNP
rs928132295 473 dbSNP
rs938163650 481 dbSNP
rs886862378 483 dbSNP
rs1290176746 484 dbSNP
rs899419323 496 dbSNP
rs1363731096 497 dbSNP
rs757892087 498 dbSNP
rs1157532899 500 dbSNP
rs1476401996 507 dbSNP
rs1419089187 515 dbSNP
rs573163783 516 dbSNP
rs1299389226 517 dbSNP
rs777211763 530 dbSNP
rs1205799094 538 dbSNP
rs1485562585 541 dbSNP
rs1260098489 543 dbSNP
rs1226550161 546 dbSNP
rs1024594942 549 dbSNP
rs995081976 550 dbSNP
rs1385863005 561 dbSNP
rs1293749686 565 dbSNP
rs559324942 571 dbSNP
rs1232440160 573 dbSNP
rs571176221 575 dbSNP
rs138340774 578 dbSNP
rs1032274309 579 dbSNP
rs1383548619 584 dbSNP
rs1347129120 585 dbSNP
rs1463541233 588 dbSNP
rs886106454 590 dbSNP
rs958089738 591 dbSNP
rs1471977908 597 dbSNP
rs987996089 603 dbSNP
rs751195751 608 dbSNP
rs913956223 609 dbSNP
rs553606065 614 dbSNP
rs987591504 615 dbSNP
rs143721742 616 dbSNP
rs1481026039 621 dbSNP
rs541597834 625 dbSNP
rs1267072286 627 dbSNP
rs943410628 639 dbSNP
rs1353940144 640 dbSNP
rs147227479 651 dbSNP
rs1423449196 652 dbSNP
rs1427253112 658 dbSNP
rs1294844952 660 dbSNP
rs1372371654 661 dbSNP
rs920873733 663 dbSNP
rs575162597 664 dbSNP
rs929425140 668 dbSNP
rs982191515 676 dbSNP
rs545380004 677 dbSNP
rs1388534548 686 dbSNP
rs1195592777 691 dbSNP
rs139635147 692 dbSNP
rs200836171 695 dbSNP
rs938135286 697 dbSNP
rs1055210294 706 dbSNP
rs1198018156 715 dbSNP
rs1449770379 719 dbSNP
rs1367079890 724 dbSNP
rs1405273385 725 dbSNP
rs920768843 726 dbSNP
rs896027079 733 dbSNP
rs563705724 734 dbSNP
rs756840303 739 dbSNP
rs886076017 755 dbSNP
rs1235899794 757 dbSNP
rs1320625704 760 dbSNP
rs1008965896 766 dbSNP
rs1435001063 772 dbSNP
rs139556022 774 dbSNP
rs900248359 777 dbSNP
rs904828813 792 dbSNP
rs1244184556 797 dbSNP
rs1435437089 799 dbSNP
rs1289787156 804 dbSNP
rs1170858681 805 dbSNP
rs557328757 811 dbSNP
rs10411159 812 dbSNP
rs957197093 821 dbSNP
rs1182266619 827 dbSNP
rs376751205 829 dbSNP
rs1485125978 834 dbSNP
rs1212639437 835 dbSNP
rs1348117894 837 dbSNP
rs1010135231 840 dbSNP
rs1358465526 854 dbSNP
rs1216957330 857 dbSNP
rs529076627 871 dbSNP
rs971361045 874 dbSNP
rs1238819529 885 dbSNP
rs1263084879 892 dbSNP
rs926931417 899 dbSNP
rs1009524057 903 dbSNP
rs1020795623 911 dbSNP
rs982515810 913 dbSNP
rs2290692 914 dbSNP
rs1386640472 917 dbSNP
rs1424902260 918 dbSNP
rs1157723950 919 dbSNP
rs1238897835 924 dbSNP
rs878871795 925 dbSNP
rs959413768 933 dbSNP
rs563787717 934 dbSNP
rs1409536594 938 dbSNP
rs1432671736 938 dbSNP
rs1485828598 941 dbSNP
rs1236473764 947 dbSNP
rs1484478292 948 dbSNP
rs1448182475 949 dbSNP
rs749252396 951 dbSNP
rs965046248 953 dbSNP
rs973430335 954 dbSNP
rs920739056 955 dbSNP
rs1313004922 956 dbSNP
rs1234264987 957 dbSNP
rs1361753242 958 dbSNP
rs930826347 960 dbSNP
rs983666068 961 dbSNP
rs908102061 962 dbSNP
rs945016796 963 dbSNP
rs1285628373 965 dbSNP
rs1315464712 966 dbSNP
rs111436795 968 dbSNP
rs900174333 978 dbSNP
rs929566913 980 dbSNP
rs1186685985 984 dbSNP
rs1475374183 986 dbSNP
rs552625329 998 dbSNP
rs1179701180 1000 dbSNP
rs1047990966 1003 dbSNP
rs931683057 1005 dbSNP
rs1242230583 1007 dbSNP
rs1182365184 1015 dbSNP
rs1054225806 1016 dbSNP
rs917402605 1018 dbSNP
rs373516957 1022 dbSNP
rs772179922 1025 dbSNP
rs1444754527 1026 dbSNP
rs1177574693 1027 dbSNP
rs1046109162 1028 dbSNP
rs1321451798 1030 dbSNP
rs1405368465 1033 dbSNP
rs1288146440 1035 dbSNP
rs750279717 1039 dbSNP
rs1216588855 1040 dbSNP
rs1362915970 1040 dbSNP
rs1402170342 1042 dbSNP
rs866758759 1049 dbSNP
rs570810564 1051 dbSNP
rs1432918245 1053 dbSNP
rs535345923 1056 dbSNP
rs1358431021 1060 dbSNP
rs1020153654 1065 dbSNP
rs1349137397 1069 dbSNP
rs907103738 1089 dbSNP
rs1053451432 1091 dbSNP
rs547260110 1092 dbSNP
rs1187402120 1094 dbSNP
rs568605485 1097 dbSNP
rs768392852 1100 dbSNP
rs1255469749 1107 dbSNP
rs990834665 1117 dbSNP
rs1020910332 1123 dbSNP
rs890263716 1127 dbSNP
rs1385044055 1133 dbSNP
rs536027278 1136 dbSNP
rs1453514045 1137 dbSNP
rs1308316697 1142 dbSNP
rs778760618 1146 dbSNP
rs1226313889 1156 dbSNP
rs1296 1160 dbSNP
rs1008753415 1168 dbSNP
rs984023714 1169 dbSNP
rs908069610 1177 dbSNP
rs1291625215 1180 dbSNP
rs1225766526 1181 dbSNP
rs1444033196 1186 dbSNP
rs944919870 1188 dbSNP
rs1308159366 1194 dbSNP
rs377461433 1198 dbSNP
rs760846675 1199 dbSNP
rs1396407808 1201 dbSNP
rs528783635 1212 dbSNP
rs575315093 1213 dbSNP
rs1179326808 1217 dbSNP
rs973929971 1217 dbSNP
rs1265572152 1218 dbSNP
rs1481140738 1219 dbSNP
rs921576480 1220 dbSNP
rs1203339346 1224 dbSNP
rs1486758846 1229 dbSNP
rs1177947592 1234 dbSNP
rs1027637536 1237 dbSNP
rs1197470100 1239 dbSNP
rs1281207013 1243 dbSNP
rs1230751134 1246 dbSNP
rs1045705 1247 dbSNP
rs1470955311 1249 dbSNP
rs1177484306 1252 dbSNP
rs1311543476 1254 dbSNP
rs950807470 1256 dbSNP
rs1299017899 1263 dbSNP
rs542467907 1264 dbSNP
rs539121657 1265 dbSNP
rs1054153768 1271 dbSNP
rs1407687971 1273 dbSNP
rs557336202 1289 dbSNP
rs945849159 1295 dbSNP
rs1406765152 1299 dbSNP
rs1465051963 1299 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccUUACCGUCCCuuua 5'
                  ||  || |||    
Target 5' ------aaAAGCGCUGGGugug 3'
1 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_025194 | 3UTR | CAGGGAAAAGCGCUGGGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_025194 | 3UTR | CGGGCCCCUGCAGGGAAAAGCGCUGGGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000263370.2 | 3UTR | AAAAGCGCUGGGUGUGUGUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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