>ZNF175|NM_007147|3'UTR
   1 ATTCCTAGTGCATCAGCATATTCATAAATGAAATATACTCCGAGTTTCTTGAAGAAGAGAAAATCTTCTCAGAATCAGGT
  81 CTAATTATATGTTATTGAATTCATGCTTCAGAAAAACTCTAGGGATGCACTGCATGTGTGAACACATGATAAAAAAGTCA
 161 TGCTTTATTTTAGTGAGGGCAATTACAGAGAAAAGAGTAAGCAGAAATGTCCTTCTGAGTACTGGCCTCATTAAGGATTA
 241 TAAATTTTCTCCCCGGGAAGAAACCCTGACTAACGCATTGAGAAAAGCCTTTCTGTAAAGAATGGTACAAGACAGGTTGT
 321 TACTCGATTATTTATAGTAAAATATGTGGGAAATTATATCAATGATAACCCTGTTTATTGTGGGATATCAATATTTTTAA
 401 AGTGCCAACACAGTCATGATAGGACAATATTTTATGTGTGTGTGTGCGCCTTATGTATATAAGCATATATATAATATATA
 481 AGCATATTATTATATACAGGTTGAGTATCCCTTCTCCAAAATGCCTGGGATCAGAAGCATTTTGGATTTCAGATACTTAC
 561 AGATTTTGGAATATTTGCATTATATTTATTGGTTGAGCATCCCTAATCTGAAAATCCAAGATTAAATGCTCCAATTAGCA
 641 TTTCCTTTGAGCGTCATGTTAGAGTTCAAAAAGTTTCAGATTTTGGGTTTTCAGATTAGGAATACCCAACCTGTATGTAC
 721 GTATATTTCTGTATCTATGTATGTATATATATGCATATGCAGACATATGTATATGGTCTGGTCAGCATATGTGTATGTAT
 801 GCGTATGTATGTATGTATGTATGCCCTCAGTGCAGTGGGGTTTGCTGCAGAATTCACTGCATAGCAGGAGATGTAAGCAG
 881 ATGAGTTATTTTTTAAGAGAATCTAATCTAATTGTTTTTATAAAAATTATTCCCTATTGAATATTTATATAATGAGGTTG
 961 TATCAACAATGATTAACTCCTTTATTATACATACACATGAATGTGCATTTTTGGTAAATGCATAAATGAGATTCTATAAT
1041 GTTTACTGATCTTTATATTACAGATTTTCTCTTCTTTTAGGATTAGCTCAGCTTGCCCCCCCTTTCCATCTCCACCATCT
1121 ATAGTGAGCCTCTCCATAATTAGTGCCAACCATTAGTCTCGTTCATATTTTTACACCAGGAGTCAACAAACTGTGGCCAT
1201 TGGCCAAATATGGCCTCCCAACTGTTTTTTTAAAATAAAGTTTTATTGGAACACAGCCATGTTCATTTGGAAAAAAAAAA
1281 AAAAAAA

ID	Duplex structure	Position	Score	MFE
1	miRNA 3' gacAGGAACCGUUUCUCUUgu 5' |:|||| :||||||| Target 5' agtTTCTTGAAGAAGAGAAaa 3'	43 - 63	146.00	-13.60
2	miRNA 3' gaCAGGAACCGUUUCUCUUGu 5' ||: || : |||||||: Target 5' gaGTTATTTTTTAAGAGAATc 3'	883 - 903	139.00	-7.54
3	miRNA 3' gacaggaaCCGUU----UCUCUUgu 5' ||||| |||||| Target 5' ttagtgagGGCAATTACAGAGAAaa 3'	170 - 194	131.00	-10.70

Mutant ID	Mutant Position	Mutant Source
COSN30192252	41	COSMIC
COSN6146494	49	COSMIC
COSN30454147	64	COSMIC
COSN15314995	73	COSMIC
COSN7448475	255	COSMIC
COSN21661791	291	COSMIC
COSN21871894	510	COSMIC
COSN6146495	734	COSMIC
COSN24739449	893	COSMIC
COSN31966249	1101	COSMIC
COSN30569789	1103	COSMIC
COSN30613695	1106	COSMIC
COSN4778575	1167	COSMIC
COSN24403058	1200	COSMIC
COSN25948175	1433	COSMIC
COSN17435522	1550	COSMIC
COSN17436414	1579	COSMIC
COSN8552991	1988	COSMIC
COSN4710468	2540	COSMIC
COSN187640	2545	COSMIC
COSN8975240	2837	COSMIC
COSN4968204	3425	COSMIC

Mutant ID	Mutant Position	Mutant Source
rs1393977888	1	dbSNP
rs747898244	3	dbSNP
rs1290579064	9	dbSNP
rs1332415186	10	dbSNP
rs755960313	10	dbSNP
rs777234260	12	dbSNP
rs748977243	16	dbSNP
rs919102553	17	dbSNP
rs770331722	19	dbSNP
rs1225619799	20	dbSNP
rs1447443360	22	dbSNP
rs1422041584	26	dbSNP
rs774053397	27	dbSNP
rs1167747684	31	dbSNP
rs747486674	34	dbSNP
rs769246520	37	dbSNP
rs777295979	42	dbSNP
rs762022240	43	dbSNP
rs1368032747	46	dbSNP
rs765636026	50	dbSNP
rs371456854	51	dbSNP
rs570524344	57	dbSNP
rs1063973	63	dbSNP
rs1439814626	64	dbSNP
rs1056177813	66	dbSNP
rs79610814	73	dbSNP
rs1198984279	74	dbSNP
rs927849475	76	dbSNP
rs1012391571	80	dbSNP
rs776921971	81	dbSNP
rs749228601	82	dbSNP
rs1283136322	88	dbSNP
rs888036517	96	dbSNP
rs1378594878	115	dbSNP
rs937690721	119	dbSNP
rs1336384170	123	dbSNP
rs1446426271	131	dbSNP
rs568275059	135	dbSNP
rs1005108749	137	dbSNP
rs1015341993	139	dbSNP
rs1226330790	141	dbSNP
rs1278620143	144	dbSNP
rs878978205	146	dbSNP
rs1054813665	151	dbSNP
rs183684894	163	dbSNP
rs1161489727	164	dbSNP
rs1471210489	165	dbSNP
rs1309734872	172	dbSNP
rs966000522	180	dbSNP
rs1262481057	181	dbSNP
rs553615622	183	dbSNP
rs946490158	188	dbSNP
rs565657719	189	dbSNP
rs1042497960	196	dbSNP
rs1029121273	205	dbSNP
rs1452070800	216	dbSNP
rs953430299	222	dbSNP
rs1259231941	223	dbSNP
rs1289088264	227	dbSNP
rs1207495320	243	dbSNP
rs533886683	255	dbSNP
rs915057258	256	dbSNP
rs1239058107	258	dbSNP
rs1375123098	265	dbSNP
rs1192850965	268	dbSNP
rs558538102	275	dbSNP
rs968374882	276	dbSNP
rs1424815511	284	dbSNP
rs978003054	296	dbSNP
rs923848746	302	dbSNP
rs1479030149	303	dbSNP
rs1421519412	304	dbSNP
rs890048714	322	dbSNP
rs939061882	326	dbSNP
rs189501032	327	dbSNP
rs962997203	332	dbSNP
rs182052161	337	dbSNP
rs1478242063	342	dbSNP
rs1026145113	359	dbSNP
rs1466611490	363	dbSNP
rs1530877	368	dbSNP
rs575009343	371	dbSNP
rs1286172123	380	dbSNP
rs981930745	386	dbSNP
rs1382988316	392	dbSNP
rs1381881932	405	dbSNP
rs1280317515	409	dbSNP
rs773144136	416	dbSNP
rs1344755883	423	dbSNP
rs1273576336	428	dbSNP
rs1402459532	435	dbSNP
rs927754973	435	dbSNP
rs1342112146	441	dbSNP
rs542466620	444	dbSNP
rs1398256403	445	dbSNP
rs1361053405	446	dbSNP
rs187167405	448	dbSNP
rs369023112	449	dbSNP
rs548492379	456	dbSNP
rs1478787295	460	dbSNP
rs1263850449	461	dbSNP
rs1192240188	467	dbSNP
rs1005552874	483	dbSNP
rs1238776471	485	dbSNP
rs1487027899	485	dbSNP
rs1210468948	486	dbSNP
rs1258447932	489	dbSNP
rs1442192852	492	dbSNP
rs767029906	495	dbSNP
rs902092607	497	dbSNP
rs75756271	501	dbSNP
rs1319155648	505	dbSNP
rs1216845717	513	dbSNP
rs1278136673	524	dbSNP
rs1216803448	528	dbSNP
rs1381523721	537	dbSNP
rs564156569	556	dbSNP
rs374294586	561	dbSNP
rs1358333198	563	dbSNP
rs953460900	573	dbSNP
rs933712632	574	dbSNP
rs1011622994	583	dbSNP
rs549883532	590	dbSNP
rs967944287	594	dbSNP
rs7246433	602	dbSNP
rs1426213260	604	dbSNP
rs1007148173	609	dbSNP
rs1362163459	611	dbSNP
rs1482746718	622	dbSNP
rs35334958	633	dbSNP
rs1030902092	635	dbSNP
rs960597515	640	dbSNP
rs1458498783	648	dbSNP
rs760111901	652	dbSNP
rs1159456105	653	dbSNP
rs117687667	654	dbSNP
rs1422512260	661	dbSNP
rs1227846787	667	dbSNP
rs947807024	673	dbSNP
rs1302314232	679	dbSNP
rs1311751767	686	dbSNP
rs1448630804	688	dbSNP
rs1400845380	695	dbSNP
rs984523395	711	dbSNP
rs1330576545	713	dbSNP
rs908948407	717	dbSNP
rs547191845	721	dbSNP
rs565598541	722	dbSNP
rs12610108	733	dbSNP
rs1180197835	738	dbSNP
rs1036919177	744	dbSNP
rs1238008005	744	dbSNP
rs971486331	746	dbSNP
rs902110539	747	dbSNP
rs1034855672	750	dbSNP
rs1304183690	753	dbSNP
rs933537262	760	dbSNP
rs1489732873	767	dbSNP
rs190345194	769	dbSNP
rs1220848516	770	dbSNP
rs1320001991	791	dbSNP
rs1288418237	795	dbSNP
rs1241222036	798	dbSNP
rs1456965933	803	dbSNP
rs201415493	803	dbSNP
rs3838910	803	dbSNP
rs889088754	803	dbSNP
rs967764126	803	dbSNP
rs1011986592	804	dbSNP
rs1419976608	807	dbSNP
rs140675591	814	dbSNP
rs75538664	815	dbSNP
rs1356825249	819	dbSNP
rs903249573	826	dbSNP
rs1180050489	827	dbSNP
rs923584530	830	dbSNP
rs1268582379	837	dbSNP
rs1220644009	839	dbSNP
rs759123075	840	dbSNP
rs1489875500	841	dbSNP
rs1050768014	850	dbSNP
rs765801751	856	dbSNP
rs1353207908	859	dbSNP
rs570850953	863	dbSNP
rs1284174247	864	dbSNP
rs375492493	866	dbSNP
rs1030761210	869	dbSNP
rs960629675	871	dbSNP
rs1249101797	880	dbSNP
rs1301881182	880	dbSNP
rs991995749	895	dbSNP
rs1439152210	897	dbSNP
rs1299458660	903	dbSNP
rs1400107593	908	dbSNP
rs1179414521	909	dbSNP
rs1359431698	935	dbSNP
rs1023264578	936	dbSNP
rs969114393	940	dbSNP
rs898728779	953	dbSNP
rs994402929	953	dbSNP
rs1382332572	957	dbSNP
rs1047113603	958	dbSNP
rs1430188748	964	dbSNP
rs907163446	968	dbSNP
rs1194413737	972	dbSNP
rs975615060	980	dbSNP
rs750701578	981	dbSNP
rs758800709	989	dbSNP
rs75910487	992	dbSNP
rs780352873	995	dbSNP
rs556594915	997	dbSNP
rs1222708089	1007	dbSNP
rs574841330	1014	dbSNP
rs1446791178	1015	dbSNP
rs1022098749	1019	dbSNP
rs1339357023	1020	dbSNP
rs968386374	1026	dbSNP
rs1481621898	1036	dbSNP
rs1176783065	1037	dbSNP
rs933568426	1041	dbSNP
rs1412268188	1046	dbSNP
rs1050701119	1049	dbSNP
rs752151286	1057	dbSNP
rs977993272	1058	dbSNP
rs1345742037	1067	dbSNP
rs1374107293	1069	dbSNP
rs1468588663	1072	dbSNP
rs536018727	1075	dbSNP
rs1429990684	1080	dbSNP
rs1296229544	1083	dbSNP
rs73050842	1087	dbSNP
rs1193829350	1088	dbSNP
rs755314529	1089	dbSNP
rs1405312855	1091	dbSNP
rs1284176606	1096	dbSNP
rs773300292	1099	dbSNP
rs763297003	1101	dbSNP
rs1054328	1102	dbSNP
rs1317561690	1103	dbSNP
rs999319219	1107	dbSNP
rs1284489663	1117	dbSNP
rs1030793625	1118	dbSNP
rs1255769498	1120	dbSNP
rs1202738967	1122	dbSNP
rs1490947329	1125	dbSNP
rs1200517825	1126	dbSNP
rs1245804650	1127	dbSNP
rs1199252670	1138	dbSNP
rs1322660243	1158	dbSNP
rs1476811415	1160	dbSNP
rs896288179	1161	dbSNP
rs748302935	1162	dbSNP
rs1399608227	1163	dbSNP
rs1156837015	1175	dbSNP
rs770736339	1177	dbSNP
rs920083609	1182	dbSNP
rs969691728	1188	dbSNP
rs1450907438	1189	dbSNP
rs1005913872	1197	dbSNP
rs554449501	1200	dbSNP
rs1332608449	1202	dbSNP
rs1465599982	1214	dbSNP
rs1016320865	1216	dbSNP
rs1457717403	1223	dbSNP
rs1199289847	1225	dbSNP
rs961824078	1233	dbSNP
rs1368052780	1237	dbSNP
rs930223304	1247	dbSNP
rs1133254	1254	dbSNP
rs1442527117	1260	dbSNP
rs971774288	1269	dbSNP
rs1181467053	1272	dbSNP
rs923009918	1286	dbSNP
rs1437120259	1294	dbSNP
rs572774643	1299	dbSNP
rs1168063850	1307	dbSNP
rs986282390	1308	dbSNP
rs938663684	1310	dbSNP
rs1290565713	1313	dbSNP
rs1055914169	1318	dbSNP
rs1372370762	1320	dbSNP
rs894540221	1324	dbSNP
rs1011636230	1327	dbSNP
rs61422446	1328	dbSNP
rs947595771	1333	dbSNP
rs1403222690	1340	dbSNP
rs1406018312	1341	dbSNP
rs1043078462	1342	dbSNP
rs1161875716	1347	dbSNP
rs924566230	1348	dbSNP
rs1381183840	1353	dbSNP
rs934768634	1362	dbSNP
rs1158972176	1365	dbSNP
rs1451347361	1368	dbSNP
rs1231038160	1370	dbSNP
rs1200987306	1381	dbSNP
rs903649552	1386	dbSNP
rs1303057603	1392	dbSNP
rs1380978029	1396	dbSNP
rs1355349029	1399	dbSNP
rs1230324659	1403	dbSNP
rs1223513429	1405	dbSNP
rs1349071811	1408	dbSNP
rs1277102918	1410	dbSNP
rs1293898207	1414	dbSNP
rs375328376	1418	dbSNP
rs3838909	1418	dbSNP
rs74622204	1418	dbSNP
rs753912088	1418	dbSNP
rs143948732	1426	dbSNP
rs144858167	1428	dbSNP
rs150987341	1429	dbSNP
rs74520240	1430	dbSNP
rs955063916	1436	dbSNP
rs1044863331	1439	dbSNP
rs1017865684	1440	dbSNP
rs543071841	1445	dbSNP
rs745593872	1450	dbSNP
rs1428546488	1455	dbSNP
rs1015940824	1467	dbSNP
rs1196579483	1468	dbSNP
rs962050107	1469	dbSNP
rs1209589205	1470	dbSNP
rs1214700370	1471	dbSNP
rs561775225	1477	dbSNP
rs528964754	1479	dbSNP
rs1220204946	1481	dbSNP
rs1030110462	1482	dbSNP
rs1323386543	1489	dbSNP
rs1281944251	1505	dbSNP
rs1341279612	1508	dbSNP
rs954434117	1508	dbSNP
rs986313375	1509	dbSNP
rs1361149466	1514	dbSNP
rs1184506650	1520	dbSNP
rs983073658	1521	dbSNP
rs181669484	1525	dbSNP
rs1262238354	1527	dbSNP
rs1478046396	1529	dbSNP
rs910686254	1531	dbSNP
rs938694706	1534	dbSNP
rs1423773314	1536	dbSNP
rs73562642	1537	dbSNP
rs1176163706	1539	dbSNP
rs979387833	1545	dbSNP
rs1360478396	1550	dbSNP
rs1238862222	1560	dbSNP
rs1428243827	1561	dbSNP
rs924879730	1562	dbSNP
rs533032840	1569	dbSNP
rs951768510	1579	dbSNP
rs112308395	1580	dbSNP
rs1401044621	1582	dbSNP
rs1280643144	1588	dbSNP
rs1201137241	1595	dbSNP
rs1322041180	1599	dbSNP
rs934699756	1602	dbSNP
rs1218661157	1604	dbSNP
rs771859979	1615	dbSNP
rs1212903493	1618	dbSNP
rs1314120821	1620	dbSNP
rs903723763	1624	dbSNP
rs750815548	1633	dbSNP
rs775330758	1634	dbSNP
rs948777241	1656	dbSNP
rs1044879360	1657	dbSNP
rs760298201	1661	dbSNP
rs58908671	1669	dbSNP
rs1018361332	1672	dbSNP
rs1169077463	1673	dbSNP
rs1195666023	1676	dbSNP
rs113139567	1683	dbSNP
rs575903670	1684	dbSNP
rs374009160	1696	dbSNP
rs1241727222	1697	dbSNP
rs549917896	1701	dbSNP
rs1426703073	1704	dbSNP
rs1251254722	1713	dbSNP
rs982937708	1716	dbSNP
rs993193696	1720	dbSNP
rs1245578708	1732	dbSNP
rs960279725	1746	dbSNP
rs1312598295	1751	dbSNP
rs991704760	1753	dbSNP
rs1373898119	1755	dbSNP
rs1297544944	1757	dbSNP
rs1439390233	1759	dbSNP
rs1029976195	1765	dbSNP
rs1157655900	1766	dbSNP
rs1360844067	1783	dbSNP
rs756425300	1793	dbSNP
rs947404404	1809	dbSNP
rs148456823	1825	dbSNP
rs1007274875	1828	dbSNP
rs1329806401	1830	dbSNP
rs780681012	1830	dbSNP
rs1423562098	1837	dbSNP
rs544998495	1839	dbSNP
rs1043557526	1843	dbSNP
rs1017778758	1849	dbSNP
rs1250424781	1850	dbSNP
rs1275998248	1853	dbSNP
rs1176041484	1855	dbSNP
rs1369787943	1860	dbSNP
rs984476204	1862	dbSNP
rs924706460	1871	dbSNP
rs1222192716	1877	dbSNP
rs969323659	1878	dbSNP
rs978949347	1880	dbSNP
rs1247412100	1887	dbSNP
rs1221887778	1897	dbSNP
rs934716061	1906	dbSNP
rs1288447352	1910	dbSNP
rs1032361910	1911	dbSNP
rs574456785	1911	dbSNP
rs956277673	1916	dbSNP
rs992800625	1922	dbSNP
rs186613988	1931	dbSNP
rs367545147	1932	dbSNP
rs1008108007	1933	dbSNP
rs1354692994	1936	dbSNP
rs1039616834	1938	dbSNP
rs1299724486	1939	dbSNP
rs1454615096	1950	dbSNP
rs776078580	1964	dbSNP
rs1287432216	1972	dbSNP
rs1289354525	1987	dbSNP
rs899536611	1999	dbSNP
rs112822179	2004	dbSNP
rs761406500	2007	dbSNP
rs1430642809	2022	dbSNP
rs565407140	2023	dbSNP
rs35088603	2025	dbSNP
rs1035866537	2027	dbSNP
rs1206005915	2030	dbSNP
rs960185259	2041	dbSNP
rs1248435458	2051	dbSNP
rs1213410821	2052	dbSNP
rs142595684	2057	dbSNP
rs1037529815	2058	dbSNP
rs1177468956	2065	dbSNP
rs897760935	2072	dbSNP
rs1441185725	2077	dbSNP
rs929186373	2082	dbSNP
rs1160781920	2085	dbSNP
rs750942045	2098	dbSNP
rs1388981454	2108	dbSNP
rs540055029	2109	dbSNP
rs1405189077	2111	dbSNP
rs547837204	2125	dbSNP
rs1051429663	2136	dbSNP
rs890089867	2140	dbSNP
rs1352188830	2161	dbSNP
rs924582553	2164	dbSNP
rs1007222832	2166	dbSNP
rs1425933424	2173	dbSNP
rs934750209	2174	dbSNP
rs1428090543	2181	dbSNP
rs1377868930	2189	dbSNP
rs1259930300	2196	dbSNP
rs1203087125	2199	dbSNP
rs151074308	2201	dbSNP
rs1242627650	2202	dbSNP
rs1252510206	2204	dbSNP
rs1313240107	2208	dbSNP
rs1017809568	2216	dbSNP
rs904253541	2218	dbSNP
rs34321116	2219	dbSNP
rs1398154674	2222	dbSNP
rs943871799	2226	dbSNP
rs1197402783	2230	dbSNP
rs1031810476	2240	dbSNP
rs1238288765	2242	dbSNP
rs1468739944	2248	dbSNP
rs1329916242	2252	dbSNP
rs1403125108	2255	dbSNP
rs561570309	2259	dbSNP
rs1461548898	2271	dbSNP
rs779158829	2293	dbSNP
rs899737205	2296	dbSNP
rs993006749	2297	dbSNP
rs370281454	2298	dbSNP
rs1024504965	2301	dbSNP
rs755222898	2302	dbSNP
rs1459884729	2305	dbSNP
rs970072824	2306	dbSNP
rs886738986	2312	dbSNP
rs1195806197	2313	dbSNP
rs1003996952	2315	dbSNP
rs1249249366	2317	dbSNP
rs1247783436	2326	dbSNP
rs1360580852	2329	dbSNP
rs1035434542	2337	dbSNP
rs1450930235	2340	dbSNP
rs1379674105	2342	dbSNP
rs1330223619	2345	dbSNP
rs1472670151	2349	dbSNP
rs896007871	2355	dbSNP
rs1013073309	2360	dbSNP
rs1165186992	2361	dbSNP
rs573398579	2374	dbSNP
rs980108990	2380	dbSNP
rs909988911	2388	dbSNP
rs1164206304	2392	dbSNP
rs1162634893	2397	dbSNP
rs34671792	2408	dbSNP
rs1416519754	2409	dbSNP
rs1464543786	2416	dbSNP
rs941427040	2426	dbSNP
rs973664648	2428	dbSNP
rs919051259	2433	dbSNP
rs540752494	2435	dbSNP
rs1234530134	2437	dbSNP
rs1401084759	2442	dbSNP
rs1231412880	2444	dbSNP
rs1247856954	2465	dbSNP
rs113556941	2475	dbSNP
rs969014707	2477	dbSNP
rs559105388	2487	dbSNP
rs545626929	2491	dbSNP
rs979383018	2495	dbSNP
rs1449154411	2500	dbSNP
rs1290582292	2505	dbSNP
rs1244230006	2512	dbSNP
rs532925503	2517	dbSNP
rs1051713871	2520	dbSNP
rs1280624708	2525	dbSNP
rs1239005131	2528	dbSNP
rs113581628	2539	dbSNP
rs1304977638	2541	dbSNP
rs879386288	2544	dbSNP
rs911807998	2547	dbSNP
rs77903506	2550	dbSNP
rs112295567	2554	dbSNP
rs904283932	2555	dbSNP
rs1315943203	2564	dbSNP
rs1217903573	2566	dbSNP
rs1469529672	2570	dbSNP
rs79020977	2571	dbSNP
rs1053224642	2576	dbSNP
rs1480516553	2585	dbSNP
rs1267713577	2586	dbSNP
rs1219856020	2587	dbSNP
rs1449065553	2589	dbSNP
rs1319364899	2592	dbSNP
rs550504812	2593	dbSNP
rs1204936764	2599	dbSNP
rs921074700	2607	dbSNP
rs1285760667	2609	dbSNP
rs931250298	2614	dbSNP
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rs970272403	2621	dbSNP
rs1188625986	2633	dbSNP
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rs1016914962	2643	dbSNP
rs752671591	2644	dbSNP
rs1386354505	2650	dbSNP
rs568495265	2656	dbSNP
rs562866375	2657	dbSNP
rs972806477	2660	dbSNP
rs1486730486	2686	dbSNP
rs189985556	2687	dbSNP
rs1242347800	2691	dbSNP
rs950568210	2693	dbSNP
rs146190095	2695	dbSNP
rs1000488307	2696	dbSNP
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rs1261296430	2701	dbSNP
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rs12975196	2718	dbSNP
rs1470216012	2726	dbSNP
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rs386810361	2738	dbSNP
rs879379016	2738	dbSNP
rs6509555	2739	dbSNP
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rs908443612	2760	dbSNP
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rs1045849741	2819	dbSNP
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rs906128500	2864	dbSNP
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rs878931760	2874	dbSNP
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rs1300560527	2996	dbSNP
rs1348540815	2997	dbSNP
rs1331158263	2999	dbSNP
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rs911703349	3016	dbSNP
rs1481496950	3021	dbSNP
rs563385304	3021	dbSNP
rs964988665	3026	dbSNP
rs1352536137	3027	dbSNP
rs1263419461	3039	dbSNP
rs1216281846	3062	dbSNP
rs1217708402	3065	dbSNP
rs1044175875	3067	dbSNP
rs530814625	3068	dbSNP
rs925681441	3069	dbSNP
rs1226036782	3072	dbSNP
rs1287226444	3077	dbSNP
rs1283489162	3078	dbSNP
rs1487077332	3085	dbSNP
rs1208555490	3089	dbSNP
rs935726137	3101	dbSNP
rs974721937	3102	dbSNP
rs1454630570	3103	dbSNP
rs936626817	3103	dbSNP
rs200724406	3114	dbSNP
rs1053237202	3120	dbSNP
rs1433836044	3121	dbSNP
rs1201094076	3122	dbSNP
rs1293362098	3129	dbSNP
rs1430123282	3130	dbSNP
rs925860277	3140	dbSNP
rs11883251	3144	dbSNP
rs988424341	3145	dbSNP
rs1264141587	3148	dbSNP
rs184246855	3149	dbSNP
rs1158986125	3151	dbSNP
rs529277509	3159	dbSNP
rs547816190	3163	dbSNP
rs1362189781	3168	dbSNP
rs1206788240	3171	dbSNP
rs1456247358	3174	dbSNP
rs912998147	3180	dbSNP
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rs533304204	3189	dbSNP
rs1328926059	3191	dbSNP
rs1297353845	3198	dbSNP
rs188697708	3202	dbSNP
rs193189213	3203	dbSNP
rs1319098068	3207	dbSNP
rs1455016927	3208	dbSNP
rs537731280	3242	dbSNP
rs4802818	3243	dbSNP
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rs1027625843	3256	dbSNP
rs1240381807	3264	dbSNP
rs1428860751	3267	dbSNP
rs1247138262	3270	dbSNP
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rs1462551054	3276	dbSNP
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rs952245654	3287	dbSNP
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rs994197350	3293	dbSNP
rs1319091945	3294	dbSNP
rs1243150334	3296	dbSNP
rs1265299671	3297	dbSNP
rs1371113158	3299	dbSNP
rs386389213	3299	dbSNP
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rs1341063658	3308	dbSNP
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rs1215580362	3310	dbSNP
rs1295801816	3311	dbSNP
rs200656534	3311	dbSNP
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rs75829019	3316	dbSNP
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rs1459407008	3320	dbSNP
rs8112486	3321	dbSNP
rs1398891933	3322	dbSNP
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rs1272053403	3327	dbSNP
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rs577341987	3329	dbSNP
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rs980190041	3332	dbSNP
rs1305246234	3335	dbSNP
rs1368938528	3335	dbSNP
rs1235651299	3339	dbSNP
rs1467044222	3340	dbSNP
rs375272724	3346	dbSNP
rs1025620422	3347	dbSNP
rs1472017545	3348	dbSNP
rs891233567	3348	dbSNP
rs935757452	3349	dbSNP
rs1224318684	3352	dbSNP
rs561121740	3354	dbSNP
rs1008275970	3355	dbSNP
rs1261893359	3356	dbSNP
rs944855664	3358	dbSNP
rs1019201903	3361	dbSNP
rs35470975	3363	dbSNP
rs528403607	3363	dbSNP
rs4802820	3364	dbSNP
rs4801879	3365	dbSNP
rs957488997	3366	dbSNP
rs1159135011	3370	dbSNP
rs932228859	3371	dbSNP
rs369243078	3372	dbSNP
rs912862494	3376	dbSNP
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rs551615119	3384	dbSNP
rs887749036	3385	dbSNP
rs4802821	3388	dbSNP
rs927030191	3389	dbSNP
rs530982201	3391	dbSNP
rs1273368059	3392	dbSNP
rs187254706	3395	dbSNP
rs546248824	3396	dbSNP
rs1024113276	3399	dbSNP
rs898760182	3402	dbSNP
rs376173440	3403	dbSNP
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rs546168696	3406	dbSNP
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rs1008229892	3410	dbSNP
rs1243013236	3415	dbSNP
rs1188349846	3424	dbSNP
rs370105736	3427	dbSNP
rs899902841	3428	dbSNP
rs1441979100	3429	dbSNP
rs1276742506	3431	dbSNP
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rs996038863	3434	dbSNP
rs922083770	3435	dbSNP
rs79052182	3440	dbSNP
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rs115298944	3468	dbSNP
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rs12461017	3504	dbSNP
rs1347036508	3506	dbSNP
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rs1348631021	3511	dbSNP
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rs1161973653	3513	dbSNP
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rs1217837432	3515	dbSNP
rs1244971335	3516	dbSNP
rs201965196	3517	dbSNP
rs779503436	3517	dbSNP
rs893004021	3518	dbSNP
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rs1045150353	3525	dbSNP
rs1365975747	3526	dbSNP
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rs1001360425	3527	dbSNP
rs1320841209	3529	dbSNP
rs1002558241	3531	dbSNP
rs1181512648	3532	dbSNP
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rs1378412343	3533	dbSNP
rs1432354926	3534	dbSNP
rs538211098	3537	dbSNP
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rs1294218151	3539	dbSNP
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rs778095726	3542	dbSNP
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rs184135901	3544	dbSNP
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rs536398065	3548	dbSNP
rs141483373	3549	dbSNP
rs951549441	3550	dbSNP
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rs1356510848	3552	dbSNP
rs984989810	3553	dbSNP
rs188468077	3554	dbSNP
rs1221603445	3576	dbSNP
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rs1425514320	3582	dbSNP
rs962292106	3588	dbSNP
rs1199400857	3595	dbSNP
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rs972277957	3611	dbSNP
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rs78025665	3808	dbSNP
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rs989429901	3909	dbSNP
rs192233150	3911	dbSNP
rs901773705	3913	dbSNP
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rs1249264089	3916	dbSNP
rs1041536073	3917	dbSNP
rs907011672	3930	dbSNP
rs1463637360	3946	dbSNP
rs938521638	3950	dbSNP
rs1219996575	3958	dbSNP
rs1344609023	3959	dbSNP
rs532882499	3968	dbSNP
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rs543981259	3975	dbSNP
rs1415237081	3978	dbSNP
rs572147259	3984	dbSNP
rs1231817678	3989	dbSNP
rs1294977820	3991	dbSNP
rs888746078	3993	dbSNP
rs769377037	3994	dbSNP
rs1026626572	3998	dbSNP
rs75348659	4013	dbSNP
rs1414621367	4021	dbSNP
rs1003929648	4026	dbSNP
rs993654948	4032	dbSNP
rs772751736	4039	dbSNP
rs1340912511	4040	dbSNP
rs1451783873	4042	dbSNP

- Genes & development, 2013

When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.