pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ORMDL2   
Synonyms HSPC160, MST095, MSTP095, adoplin-2
Description ORMDL sphingolipid biosynthesis regulator 2
Transcript NM_014182   
Expression
Putative miRNA Targets on ORMDL2
3'UTR of ORMDL2
(miRNA target sites are highlighted)
>ORMDL2|NM_014182|3'UTR
   1 GGGATGGGTTTTGGGACAGCTCCATGGGCATGGGGAAGGCACTGAAACAGAGGACTATAAAACATCCTTCTCTTATTCTC
  81 CATACTGTCTTCTACACCTTTAAAGCCTGAGAACTATACAACCTTTCCCAGACTCCCAAGAAGAGAAGAGATTGGCAAAT
 161 GGGGCTCCTGGGCCCAGTCCTGCTAGTGGCAAGTTTCTTTGAATCAGGAAGGCAGGTGAGGTAAGGGCCAAATCACTCTC
 241 CTCCATAGCAGGAAGCCATTTGGGCAGCTTCTTTGGTGATTACATCTTTCCATATCTTTTACACTTACCACCTTCCAGCT
 321 CTGTTTTGCTGTGTATTTTTCTTACAATAATTTTTTTCAGCTATAGCTGCAGTTTAATCAGGATGGGTAGAGAGCTGTCC
 401 TCATAAGGCTGGGGGTGGGAAGATGGAATACTGACCTAATGTATAAAACTTAAAACAATTCTCCAATCCCCTCTCCTTTG
 481 GTCCAGTAGGAGGTGCCCTTCACTCTAAGCTTAACACTTAGTAGGGAAGAGATTCTCAAATGAGAAAAAGGGCTCCGGCT
 561 ATATGGGCAACAAAGAGGGAAGATACAGGTTGCCAGTTATACATTTATAGAAAGATAATCCCCTGGCTTTAAATAGTCAT
 641 GTACATACAAATATGAACAAACTTAAAAAAAAAATACAAACCCTTGGATCACATGGGGGCTTCTGGGAACCCCCGTATTC
 721 TTCCCCCTCACCCAAGGGCAGTGGGCATGAATCTACTTTTTAAAAATGATTAATTTTGGCAAAAAAAAAAAAAAAAAAAA
 801 AAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgguucccuuACCGUCCCUUUa 5'
                    | |:||||||: 
Target 5' gcttaacactTAGTAGGGAAGa 3'
509 - 530 132.00 -11.60
2
miRNA  3' cgGUUCCC----UUACCGUCCCUUUa 5'
            :| |||    || |  ||||||: 
Target 5' taTATGGGCAACAAAG--AGGGAAGa 3'
560 - 583 130.00 -11.00
3
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            || ||| ||   :|||||: 
Target 5' tcCATGGGCAT---GGGGAAGg 3'
21 - 39 125.00 -17.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30141052 39 COSMIC
COSN30515437 53 COSMIC
COSN1149768 57 COSMIC
COSN31582062 81 COSMIC
COSN30462951 112 COSMIC
COSN30168042 120 COSMIC
COSN30145974 144 COSMIC
COSN31522316 207 COSMIC
COSN1577245 307 COSMIC
COSN1149771 316 COSMIC
COSN30348651 467 COSMIC
COSN28757585 500 COSMIC
COSN9751980 556 COSMIC
COSN25104500 658 COSMIC
COSN29537991 675 COSMIC
COSN26569216 676 COSMIC
COSN24698093 733 COSMIC
COSN31552581 862 COSMIC
COSN5717410 868 COSMIC
COSN5324333 876 COSMIC
COSN29271027 911 COSMIC
COSN20109696 912 COSMIC
COSN21960526 980 COSMIC
COSN31580041 1006 COSMIC
COSN31608146 1011 COSMIC
COSN5946982 1046 COSMIC
COSN26678090 1105 COSMIC
COSN26562077 1118 COSMIC
COSN31564198 1306 COSMIC
COSN6536674 1319 COSMIC
COSN31481241 1441 COSMIC
COSN30112888 1467 COSMIC
COSN30121855 1474 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs368255078 2 dbSNP
rs755516615 3 dbSNP
rs765517220 5 dbSNP
rs145894501 6 dbSNP
rs1215756962 7 dbSNP
rs758671585 9 dbSNP
rs946410068 15 dbSNP
rs1244919311 19 dbSNP
rs778180037 21 dbSNP
rs747265933 23 dbSNP
rs375352682 25 dbSNP
rs1273536593 27 dbSNP
rs1484868908 28 dbSNP
rs781344544 29 dbSNP
rs745722815 30 dbSNP
rs769835196 31 dbSNP
rs1050009288 32 dbSNP
rs779697000 38 dbSNP
rs749127859 43 dbSNP
rs768474178 46 dbSNP
rs773947594 49 dbSNP
rs761470784 54 dbSNP
rs771506381 60 dbSNP
rs1312065902 63 dbSNP
rs1453497963 66 dbSNP
rs1056017638 67 dbSNP
rs548581301 68 dbSNP
rs765822021 73 dbSNP
rs752973841 79 dbSNP
rs1234415802 82 dbSNP
rs113256470 84 dbSNP
rs764575179 86 dbSNP
rs751772063 88 dbSNP
rs757556143 90 dbSNP
rs569990100 95 dbSNP
rs375046398 96 dbSNP
rs1355611176 98 dbSNP
rs750572536 99 dbSNP
rs1187908105 100 dbSNP
rs1191360626 102 dbSNP
rs755979123 105 dbSNP
rs1487676830 110 dbSNP
rs894722504 117 dbSNP
rs1411226694 128 dbSNP
rs111416072 133 dbSNP
rs1162482912 136 dbSNP
rs942299535 138 dbSNP
rs1472537563 141 dbSNP
rs1386489389 143 dbSNP
rs1176240980 146 dbSNP
rs563977009 148 dbSNP
rs1206417659 152 dbSNP
rs1449605543 153 dbSNP
rs1291331192 168 dbSNP
rs1246895743 171 dbSNP
rs1416002935 174 dbSNP
rs749783944 177 dbSNP
rs1307248426 179 dbSNP
rs1223272471 190 dbSNP
rs1374747660 195 dbSNP
rs1300373388 199 dbSNP
rs1434791376 216 dbSNP
rs1406030375 219 dbSNP
rs1365278679 225 dbSNP
rs1302151856 227 dbSNP
rs185258417 237 dbSNP
rs1030440710 238 dbSNP
rs1411978474 241 dbSNP
rs112289913 245 dbSNP
rs1308371771 247 dbSNP
rs755423873 250 dbSNP
rs1408654815 256 dbSNP
rs1178816796 259 dbSNP
rs1407871030 260 dbSNP
rs867185271 261 dbSNP
rs1222935461 269 dbSNP
rs14299 271 dbSNP
rs1285920085 273 dbSNP
rs1356360690 276 dbSNP
rs1227258303 280 dbSNP
rs1284109211 280 dbSNP
rs1215192537 282 dbSNP
rs1317543587 287 dbSNP
rs1309805189 288 dbSNP
rs118090673 292 dbSNP
rs1018145347 293 dbSNP
rs1284399238 295 dbSNP
rs878928766 303 dbSNP
rs577712540 307 dbSNP
rs990052175 309 dbSNP
rs1012925453 317 dbSNP
rs1160644847 328 dbSNP
rs1275733085 329 dbSNP
rs1482950536 331 dbSNP
rs1180565024 343 dbSNP
rs1021227253 346 dbSNP
rs1023012375 348 dbSNP
rs1199932121 351 dbSNP
rs971380032 351 dbSNP
rs981547911 353 dbSNP
rs1186091032 360 dbSNP
rs1181345443 362 dbSNP
rs570613022 364 dbSNP
rs1486238182 365 dbSNP
rs967034891 370 dbSNP
rs1208099308 377 dbSNP
rs1411768050 387 dbSNP
rs977110644 388 dbSNP
rs1264268165 391 dbSNP
rs1225771665 397 dbSNP
rs138499406 404 dbSNP
rs1338824923 410 dbSNP
rs928381290 412 dbSNP
rs142915973 413 dbSNP
rs992065619 414 dbSNP
rs924666073 419 dbSNP
rs59395135 423 dbSNP
rs1405299842 426 dbSNP
rs1177008787 434 dbSNP
rs1470842315 436 dbSNP
rs916115833 440 dbSNP
rs942248840 442 dbSNP
rs1369677530 448 dbSNP
rs1264101368 455 dbSNP
rs1180237554 458 dbSNP
rs1427590121 467 dbSNP
rs574726012 469 dbSNP
rs1244319573 481 dbSNP
rs1206048293 483 dbSNP
rs1336029500 488 dbSNP
rs536575943 489 dbSNP
rs1251158460 491 dbSNP
rs554924606 498 dbSNP
rs576370949 508 dbSNP
rs543645826 509 dbSNP
rs1297223705 517 dbSNP
rs1449859875 522 dbSNP
rs1381325365 529 dbSNP
rs565070588 543 dbSNP
rs1454579703 550 dbSNP
rs1051814402 557 dbSNP
rs368707776 558 dbSNP
rs915163706 559 dbSNP
rs879573216 562 dbSNP
rs1281895214 564 dbSNP
rs1444087176 572 dbSNP
rs1366765397 576 dbSNP
rs946662793 582 dbSNP
rs1018509085 590 dbSNP
rs1228630715 601 dbSNP
rs540416869 616 dbSNP
rs1296421643 621 dbSNP
rs899699149 622 dbSNP
rs1050294870 626 dbSNP
rs1011424682 629 dbSNP
rs1481794237 637 dbSNP
rs1341826853 641 dbSNP
rs371220284 644 dbSNP
rs910243627 645 dbSNP
rs1243238816 646 dbSNP
rs944359873 656 dbSNP
rs1315212146 663 dbSNP
rs1391784122 665 dbSNP
rs150092729 665 dbSNP
rs150551551 665 dbSNP
rs998480381 665 dbSNP
rs1281245331 666 dbSNP
rs1035401988 675 dbSNP
rs1424324846 675 dbSNP
rs1366398040 676 dbSNP
rs960052199 685 dbSNP
rs991283653 686 dbSNP
rs916047702 689 dbSNP
rs1183091309 693 dbSNP
rs576912858 696 dbSNP
rs1421253567 699 dbSNP
rs1040120139 715 dbSNP
rs897542471 716 dbSNP
rs1490098602 717 dbSNP
rs1292016591 718 dbSNP
rs1224116223 727 dbSNP
rs1235761731 730 dbSNP
rs919519572 732 dbSNP
rs929581159 737 dbSNP
rs1337447039 739 dbSNP
rs993690392 740 dbSNP
rs17118024 743 dbSNP
rs1451446495 744 dbSNP
rs1189383451 755 dbSNP
rs1052189215 762 dbSNP
rs748223182 774 dbSNP
rs887949431 787 dbSNP
rs1384259538 792 dbSNP
rs1447953498 797 dbSNP
rs1174103236 801 dbSNP
rs1427788224 807 dbSNP
rs1013209466 812 dbSNP
rs200481385 812 dbSNP
rs1023210328 814 dbSNP
rs143344071 818 dbSNP
rs772067014 819 dbSNP
rs1283009361 820 dbSNP
rs1205177876 823 dbSNP
rs190055999 826 dbSNP
rs1002844851 828 dbSNP
rs1031763098 835 dbSNP
rs77199828 836 dbSNP
rs990246346 840 dbSNP
rs1323917221 849 dbSNP
rs1285434658 855 dbSNP
rs1011372341 856 dbSNP
rs1326061803 864 dbSNP
rs148318131 868 dbSNP
rs773462463 871 dbSNP
rs141478282 872 dbSNP
rs531059934 873 dbSNP
rs1176279999 878 dbSNP
rs910448281 881 dbSNP
rs763680554 882 dbSNP
rs944390843 883 dbSNP
rs1166500087 884 dbSNP
rs374382418 889 dbSNP
rs1346180196 895 dbSNP
rs1241124959 898 dbSNP
rs1193316931 907 dbSNP
rs3064698 911 dbSNP
rs78290923 911 dbSNP
rs59926423 912 dbSNP
rs201503010 913 dbSNP
rs367953529 915 dbSNP
rs1241210884 916 dbSNP
rs370540372 918 dbSNP
rs1261826084 920 dbSNP
rs1324180079 923 dbSNP
rs919017666 925 dbSNP
rs570700853 926 dbSNP
rs1212564364 931 dbSNP
rs754561765 934 dbSNP
rs79015557 938 dbSNP
rs1270952456 945 dbSNP
rs1229738024 964 dbSNP
rs1209426278 971 dbSNP
rs546755172 976 dbSNP
rs1454049248 980 dbSNP
rs1013060137 984 dbSNP
rs1048796743 992 dbSNP
rs568512821 996 dbSNP
rs541986017 997 dbSNP
rs1418375011 1000 dbSNP
rs1168075636 1002 dbSNP
rs1450796433 1013 dbSNP
rs1382925038 1014 dbSNP
rs1477576383 1017 dbSNP
rs948842052 1022 dbSNP
rs1044681038 1024 dbSNP
rs1461751071 1027 dbSNP
rs1239100170 1029 dbSNP
rs1202224598 1030 dbSNP
rs1436967313 1030 dbSNP
rs372234259 1033 dbSNP
rs1002875932 1039 dbSNP
rs973563531 1042 dbSNP
rs1207482184 1052 dbSNP
rs919457428 1053 dbSNP
rs114376850 1054 dbSNP
rs1246758813 1078 dbSNP
rs12424201 1079 dbSNP
rs1180853111 1090 dbSNP
rs1382002811 1093 dbSNP
rs1414072941 1105 dbSNP
rs891784875 1110 dbSNP
rs987761828 1111 dbSNP
rs776623623 1112 dbSNP
rs1441949093 1118 dbSNP
rs1457764267 1123 dbSNP
rs1012101692 1131 dbSNP
rs943395770 1134 dbSNP
rs1431310685 1138 dbSNP
rs1319260966 1160 dbSNP
rs1385863439 1175 dbSNP
rs576452766 1176 dbSNP
rs1444674486 1177 dbSNP
rs1415903650 1179 dbSNP
rs1175354013 1180 dbSNP
rs915328660 1185 dbSNP
rs946842108 1186 dbSNP
rs375499901 1188 dbSNP
rs1042863680 1191 dbSNP
rs1207023567 1193 dbSNP
rs1489931562 1196 dbSNP
rs1291257032 1202 dbSNP
rs1021691749 1207 dbSNP
rs1223348275 1216 dbSNP
rs537334199 1219 dbSNP
rs561967563 1225 dbSNP
rs558822514 1227 dbSNP
rs181324049 1230 dbSNP
rs1403458994 1237 dbSNP
rs1343289211 1240 dbSNP
rs541194728 1245 dbSNP
rs1267561363 1247 dbSNP
rs1348662279 1251 dbSNP
rs1211789005 1252 dbSNP
rs1156312626 1262 dbSNP
rs1057068682 1263 dbSNP
rs1017484199 1265 dbSNP
rs758193958 1270 dbSNP
rs1184111351 1273 dbSNP
rs976024096 1278 dbSNP
rs1479304409 1282 dbSNP
rs918953039 1283 dbSNP
rs1451308204 1287 dbSNP
rs559202059 1304 dbSNP
rs928974512 1306 dbSNP
rs1489584747 1311 dbSNP
rs984971351 1313 dbSNP
rs1012593838 1319 dbSNP
rs908933392 1323 dbSNP
rs1215129277 1327 dbSNP
rs1318091987 1328 dbSNP
rs948873214 1329 dbSNP
rs1222093014 1334 dbSNP
rs1323203800 1355 dbSNP
rs1253752996 1358 dbSNP
rs1282251007 1360 dbSNP
rs34221929 1362 dbSNP
rs541424990 1371 dbSNP
rs1286666394 1376 dbSNP
rs1429361848 1379 dbSNP
rs1409078703 1380 dbSNP
rs137920300 1387 dbSNP
rs183976233 1388 dbSNP
rs1163424766 1390 dbSNP
rs756968754 1412 dbSNP
rs775000634 1418 dbSNP
rs1435180819 1421 dbSNP
rs767171600 1426 dbSNP
rs988099075 1427 dbSNP
rs1486207771 1429 dbSNP
rs754136727 1429 dbSNP
rs531569063 1448 dbSNP
rs965031515 1449 dbSNP
rs974767763 1453 dbSNP
rs1301644321 1459 dbSNP
rs1022143340 1464 dbSNP
rs1313616583 1464 dbSNP
rs534419660 1468 dbSNP
rs915277338 1468 dbSNP
rs946394105 1471 dbSNP
rs889834931 1476 dbSNP
rs978171872 1483 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccUUACCGUCCCUUUa 5'
                  || ||  |||||| 
Target 5' ------uaAAAGGGUGGGAAAa 3'
1 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000243045.5 | 3UTR | UAAAAGGGUGGGAAAAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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