pre-miRNA Information
pre-miRNA hsa-mir-3152   
Genomic Coordinates chr9: 18573306 - 18573379
Description Homo sapiens miR-3152 stem-loop
Comment Berezikov et al. proposed this sequence as a miRNA candidate based on the RAKE method .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3152-5p
Sequence 11| AUUGCCUCUGUUCUAACACAAG |32
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1019691326 2 dbSNP
rs1282676806 8 dbSNP
rs762305650 11 dbSNP
rs1364318615 12 dbSNP
rs556364307 18 dbSNP
rs1002755159 19 dbSNP
rs1238555909 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TNFRSF10A   
Synonyms APO2, CD261, DR4, TRAILR-1, TRAILR1
Description TNF receptor superfamily member 10a
Transcript NM_003844   
Expression
Putative miRNA Targets on TNFRSF10A
3'UTR of TNFRSF10A
(miRNA target sites are highlighted)
>TNFRSF10A|NM_003844|3'UTR
   1 AAGACTCTTTTTACCAGAGGTTTCCTCTTAGGTGTTAGGAGTTAATACATATTAGGTTTTTTTTTTTTTTAACATGTATA
  81 CAAAGTAAATTCTTAGCCAGGTGTAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTT
 161 GAGGTCAGAAGTTCAAGACCAGCCTGACCAACATCGTGAAATGCCGTCTTTACAAAAAAATACAAAAATTAACTGGAAAA
 241 AAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaacacAAUCUU--GUCUCCGUUa 5'
                ||:|:|  | |||||:: 
Target 5' agcactTTGGGAGGCTGAGGCGGg 3'
127 - 150 122.00 -14.70
2
miRNA  3' gaaCACAAUCUUGUCUCCGUUa 5'
             |||||||    ||| :|| 
Target 5' tagGTGTTAG----GAGTTAAt 3'
29 - 46 113.00 -10.30
3
miRNA  3' gaacacAAUCUUGUCUCCGuua 5'
                ||  | ||||||:   
Target 5' gactctTTTTACCAGAGGTttc 3'
3 - 24 100.00 -8.92
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30153862 3 COSMIC
COSN20052968 56 COSMIC
COSN1362839 57 COSMIC
COSN31608308 61 COSMIC
COSN30544462 101 COSMIC
COSN9259733 416 COSMIC
COSN24038599 651 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1334137166 4 dbSNP
rs1336736243 12 dbSNP
rs1413197621 13 dbSNP
rs1402113750 14 dbSNP
rs1270696509 19 dbSNP
rs1168913345 26 dbSNP
rs760689124 27 dbSNP
rs1227599291 33 dbSNP
rs1027286403 41 dbSNP
rs1020440066 44 dbSNP
rs775104824 48 dbSNP
rs565446378 49 dbSNP
rs1258919139 51 dbSNP
rs1010793913 52 dbSNP
rs893389716 53 dbSNP
rs1407527102 56 dbSNP
rs1055081144 57 dbSNP
rs1472365236 57 dbSNP
rs184200571 59 dbSNP
rs1468703254 60 dbSNP
rs900505323 60 dbSNP
rs1045270457 61 dbSNP
rs1397816548 70 dbSNP
rs1347245379 71 dbSNP
rs1410088962 71 dbSNP
rs1466703113 71 dbSNP
rs34127830 71 dbSNP
rs368166251 71 dbSNP
rs1221452889 73 dbSNP
rs1232264946 74 dbSNP
rs1040459967 82 dbSNP
rs944778735 83 dbSNP
rs907922261 87 dbSNP
rs573498784 89 dbSNP
rs1197664430 92 dbSNP
rs1270907272 99 dbSNP
rs1482859087 103 dbSNP
rs1200323100 116 dbSNP
rs1271312994 125 dbSNP
rs1046909728 126 dbSNP
rs929760608 131 dbSNP
rs919862437 137 dbSNP
rs1214229082 148 dbSNP
rs1463941750 148 dbSNP
rs1368092788 149 dbSNP
rs945464397 151 dbSNP
rs1428538212 155 dbSNP
rs948188183 159 dbSNP
rs1393773844 164 dbSNP
rs896594759 165 dbSNP
rs555228496 177 dbSNP
rs973978729 179 dbSNP
rs1056949834 180 dbSNP
rs935381333 183 dbSNP
rs1400322565 187 dbSNP
rs543127037 189 dbSNP
rs958398883 192 dbSNP
rs926930521 195 dbSNP
rs181853334 197 dbSNP
rs865932898 205 dbSNP
rs755568795 206 dbSNP
rs1223299113 209 dbSNP
rs979418245 211 dbSNP
rs1489911196 214 dbSNP
rs946656738 221 dbSNP
rs1262799694 222 dbSNP
rs747619325 224 dbSNP
rs1377678840 228 dbSNP
rs1169079544 239 dbSNP
rs971185991 242 dbSNP
rs1020431458 245 dbSNP
rs1191757312 247 dbSNP
rs1010410185 253 dbSNP
rs1421125400 254 dbSNP
rs868082170 254 dbSNP
rs1196364690 262 dbSNP
rs957761972 263 dbSNP
rs974578968 270 dbSNP
rs1033261534 271 dbSNP
rs1292741722 277 dbSNP
rs1385315710 278 dbSNP
rs1383701013 282 dbSNP
rs1318525325 297 dbSNP
rs996364407 300 dbSNP
rs1317194787 304 dbSNP
rs1320163260 305 dbSNP
rs900539448 321 dbSNP
rs1040364548 322 dbSNP
rs117512272 325 dbSNP
rs1027749685 331 dbSNP
rs1203736124 333 dbSNP
rs754647085 343 dbSNP
rs1462125171 347 dbSNP
rs994475888 350 dbSNP
rs1256697663 360 dbSNP
rs898777519 369 dbSNP
rs1163717242 372 dbSNP
rs1023874275 377 dbSNP
rs1364005480 387 dbSNP
rs1203826702 391 dbSNP
rs1305998611 402 dbSNP
rs1398249697 405 dbSNP
rs374859269 406 dbSNP
rs751934277 413 dbSNP
rs1338787953 420 dbSNP
rs929860469 421 dbSNP
rs766891937 433 dbSNP
rs115066235 434 dbSNP
rs1038321109 437 dbSNP
rs574686035 440 dbSNP
rs1324902297 449 dbSNP
rs1291420297 452 dbSNP
rs142478981 458 dbSNP
rs377540978 459 dbSNP
rs1297116397 462 dbSNP
rs981123704 464 dbSNP
rs1250846005 465 dbSNP
rs775598480 473 dbSNP
rs913013509 484 dbSNP
rs1410876810 491 dbSNP
rs1470122489 498 dbSNP
rs988961725 508 dbSNP
rs1044130987 515 dbSNP
rs558597049 517 dbSNP
rs957581927 521 dbSNP
rs1170908207 528 dbSNP
rs1033127495 530 dbSNP
rs1375830229 535 dbSNP
rs192344484 537 dbSNP
rs34092145 544 dbSNP
rs1288124488 550 dbSNP
rs1417619592 553 dbSNP
rs1346609751 555 dbSNP
rs1186207771 560 dbSNP
rs964949491 562 dbSNP
rs1277177436 563 dbSNP
rs925321486 563 dbSNP
rs1312087770 564 dbSNP
rs1208854335 571 dbSNP
rs1251333568 572 dbSNP
rs1483838750 573 dbSNP
rs190148539 578 dbSNP
rs1423301427 588 dbSNP
rs371777261 592 dbSNP
rs184818272 595 dbSNP
rs1176749150 598 dbSNP
rs562508240 600 dbSNP
rs148610941 601 dbSNP
rs1199487238 604 dbSNP
rs1356289233 605 dbSNP
rs1369546480 617 dbSNP
rs1026438822 625 dbSNP
rs1366398224 626 dbSNP
rs1407185083 630 dbSNP
rs1367544957 640 dbSNP
rs995313012 641 dbSNP
rs1343751569 646 dbSNP
rs201581771 647 dbSNP
rs911715010 647 dbSNP
rs898363873 648 dbSNP
rs1234840051 650 dbSNP
rs535936995 651 dbSNP
rs1341048930 653 dbSNP
rs368367270 654 dbSNP
rs937136044 655 dbSNP
rs568859600 664 dbSNP
rs1045668168 669 dbSNP
rs1488121567 673 dbSNP
rs1389215928 676 dbSNP
rs1187107950 677 dbSNP
rs1374844894 679 dbSNP
rs1331371495 683 dbSNP
rs1460624968 684 dbSNP
rs77919515 685 dbSNP
rs550507429 686 dbSNP
rs1386122536 687 dbSNP
rs949784010 688 dbSNP
rs1322001912 691 dbSNP
rs576602426 695 dbSNP
rs920343906 695 dbSNP
rs1291197663 700 dbSNP
rs1363604822 701 dbSNP
rs544234608 703 dbSNP
rs912870271 710 dbSNP
rs781473815 715 dbSNP
rs1229614501 716 dbSNP
rs935763219 722 dbSNP
rs969708353 726 dbSNP
rs1320952006 727 dbSNP
rs1023928395 729 dbSNP
rs1249859019 731 dbSNP
rs925680918 732 dbSNP
rs1369616814 736 dbSNP
rs1463453796 736 dbSNP
rs1158982611 737 dbSNP
rs1188030321 738 dbSNP
rs1417463747 739 dbSNP
rs114714450 741 dbSNP
rs1473899781 741 dbSNP
rs1161744401 742 dbSNP
rs73671077 748 dbSNP
rs1401693508 754 dbSNP
rs1161778284 756 dbSNP
rs1035615902 764 dbSNP
rs1251354727 767 dbSNP
rs1319313455 770 dbSNP
rs1382974371 771 dbSNP
rs1211461899 772 dbSNP
rs1449569659 773 dbSNP
rs539507694 775 dbSNP
rs546955333 780 dbSNP
rs1224157639 790 dbSNP
rs1019190735 793 dbSNP
rs1327012778 796 dbSNP
rs528828585 797 dbSNP
rs902627201 800 dbSNP
rs950771391 803 dbSNP
rs1043773097 805 dbSNP
rs1185471629 810 dbSNP
rs1237151330 817 dbSNP
rs1470607621 829 dbSNP
rs1318583944 841 dbSNP
rs1184808383 843 dbSNP
rs1010903155 849 dbSNP
rs900516762 850 dbSNP
rs1038970797 857 dbSNP
rs572407857 858 dbSNP
rs1404948910 863 dbSNP
rs764361231 867 dbSNP
rs1026722318 870 dbSNP
rs796122131 897 dbSNP
rs994822078 904 dbSNP
rs899267712 905 dbSNP
rs1331573194 906 dbSNP
rs1339526374 916 dbSNP
rs1033725975 919 dbSNP
rs1309392267 920 dbSNP
rs760854457 928 dbSNP
rs1348469582 929 dbSNP
rs1227539708 932 dbSNP
rs1283896934 938 dbSNP
rs1346989694 946 dbSNP
rs865845915 950 dbSNP
rs1439457669 952 dbSNP
rs774098159 955 dbSNP
rs1277933515 956 dbSNP
rs1048050658 960 dbSNP
rs905689833 971 dbSNP
rs1388953946 977 dbSNP
rs770670303 979 dbSNP
rs929136676 991 dbSNP
rs561458963 992 dbSNP
rs1472498688 993 dbSNP
rs1200557208 994 dbSNP
rs1045670868 995 dbSNP
rs1014571967 996 dbSNP
rs1452262325 997 dbSNP
rs1400789615 998 dbSNP
rs73671076 1011 dbSNP
rs1159383759 1024 dbSNP
rs117968563 1028 dbSNP
rs935629570 1032 dbSNP
rs915583382 1033 dbSNP
rs773072118 1048 dbSNP
rs925711514 1050 dbSNP
rs1038752593 1051 dbSNP
rs943580247 1054 dbSNP
rs1000127404 1061 dbSNP
rs1274182793 1065 dbSNP
rs966903371 1077 dbSNP
rs1230675054 1094 dbSNP
rs1260784450 1118 dbSNP
rs1022384580 1121 dbSNP
rs1223712397 1128 dbSNP
rs1010947346 1143 dbSNP
rs900569349 1145 dbSNP
rs1489243168 1149 dbSNP
rs1374125969 1151 dbSNP
rs1449594163 1155 dbSNP
rs1169896607 1164 dbSNP
rs1387964400 1165 dbSNP
rs912043089 1165 dbSNP
rs1039021319 1171 dbSNP
rs1286620648 1171 dbSNP
rs1392703810 1172 dbSNP
rs769793452 1173 dbSNP
rs571972600 1174 dbSNP
rs1365802704 1176 dbSNP
rs1437402530 1178 dbSNP
rs1295430276 1185 dbSNP
rs951050105 1191 dbSNP
rs1267450782 1213 dbSNP
rs563639830 1214 dbSNP
rs929163897 1216 dbSNP
rs973815631 1218 dbSNP
rs1199451943 1220 dbSNP
rs192758689 1225 dbSNP
rs1263094370 1228 dbSNP
rs186671845 1230 dbSNP
rs1380868336 1231 dbSNP
rs370542928 1232 dbSNP
rs969904875 1237 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaacacaaucuUGUCUCCGUUa 5'
                     | ||:|| |: 
Target 5' ----------cAAAGGGGGAGu 3'
1 - 12
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000221132.3 | 3UTR | AAAGGGGGAGUGAGCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000221132.3 | 3UTR | CAAAGGGGGAGUGAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
75 hsa-miR-3152-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092535 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT461731 NDUFA2 NADH:ubiquinone oxidoreductase subunit A2 2 2
MIRT468456 SET SET nuclear proto-oncogene 2 2
MIRT482192 AHR aryl hydrocarbon receptor 2 2
MIRT507923 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT512208 C18orf25 chromosome 18 open reading frame 25 2 6
MIRT526238 STARD4 StAR related lipid transfer domain containing 4 2 2
MIRT536131 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT536280 LIMA1 LIM domain and actin binding 1 2 2
MIRT544251 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT548054 GOLGA7 golgin A7 2 2
MIRT563443 ISCA1 iron-sulfur cluster assembly 1 2 2
MIRT565643 SIX4 SIX homeobox 4 2 2
MIRT614870 PDE12 phosphodiesterase 12 2 2
MIRT614923 MARCH6 membrane associated ring-CH-type finger 6 2 2
MIRT615793 FAM124A family with sequence similarity 124 member A 2 2
MIRT618557 VLDLR very low density lipoprotein receptor 2 2
MIRT622147 SORBS2 sorbin and SH3 domain containing 2 2 2
MIRT622390 RSBN1 round spermatid basic protein 1 2 2
MIRT624185 DDX19B DEAD-box helicase 19B 2 2
MIRT624448 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT625340 TAPBP TAP binding protein 2 2
MIRT625370 IRGQ immunity related GTPase Q 2 2
MIRT627276 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT627746 RAD54L2 RAD54 like 2 2 2
MIRT629578 RFC2 replication factor C subunit 2 2 4
MIRT630537 LGALS8 galectin 8 2 4
MIRT630559 C3orf36 chromosome 3 open reading frame 36 2 4
MIRT630568 SOWAHA sosondowah ankyrin repeat domain family member A 2 4
MIRT630763 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT635424 LRP10 LDL receptor related protein 10 2 2
MIRT636011 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2 2
MIRT636337 PHAX phosphorylated adaptor for RNA export 2 2
MIRT638413 POU3F2 POU class 3 homeobox 2 2 2
MIRT639358 INIP INTS3 and NABP interacting protein 2 2
MIRT642124 DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A 2 4
MIRT642828 KIAA0319 KIAA0319 2 2
MIRT644017 NUCB1 nucleobindin 1 2 2
MIRT644038 WWC2 WW and C2 domain containing 2 2 2
MIRT644153 GIN1 gypsy retrotransposon integrase 1 2 2
MIRT644649 SNX9 sorting nexin 9 2 2
MIRT645798 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT647633 FAIM2 Fas apoptotic inhibitory molecule 2 2 2
MIRT648528 KIAA1143 KIAA1143 2 2
MIRT648851 PDLIM3 PDZ and LIM domain 3 2 2
MIRT648880 TUBGCP5 tubulin gamma complex associated protein 5 2 2
MIRT650777 TNFRSF10A TNF receptor superfamily member 10a 2 2
MIRT654200 RNF19B ring finger protein 19B 2 2
MIRT654508 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT655249 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT656089 MTA3 metastasis associated 1 family member 3 2 2
MIRT656599 LRRC55 leucine rich repeat containing 55 2 2
MIRT659194 CYBB cytochrome b-245 beta chain 2 2
MIRT660000 C1orf115 chromosome 1 open reading frame 115 2 4
MIRT661715 KLF8 Kruppel like factor 8 2 2
MIRT661813 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT668360 FGD4 FYVE, RhoGEF and PH domain containing 4 2 2
MIRT679734 CABP4 calcium binding protein 4 2 2
MIRT708616 NUDT18 nudix hydrolase 18 2 2
MIRT709034 TROVE2 TROVE domain family member 2 2 2
MIRT709573 DMGDH dimethylglycine dehydrogenase 2 2
MIRT709665 AJAP1 adherens junctions associated protein 1 2 2
MIRT709874 TRAF1 TNF receptor associated factor 1 2 2
MIRT710821 NLRP12 NLR family pyrin domain containing 12 2 2
MIRT710883 PARL presenilin associated rhomboid like 2 2
MIRT711547 LCAT lecithin-cholesterol acyltransferase 2 2
MIRT712017 STX1B syntaxin 1B 2 2
MIRT713058 BLVRA biliverdin reductase A 2 2
MIRT713129 THRB thyroid hormone receptor beta 2 2
MIRT713878 MOB3A MOB kinase activator 3A 2 2
MIRT714154 NXPH3 neurexophilin 3 2 2
MIRT719755 FLYWCH1 FLYWCH-type zinc finger 1 2 2
MIRT720213 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT722728 BRMS1 breast cancer metastasis suppressor 1 2 2
MIRT725652 ABI2 abl interactor 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)

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