pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GSR   
Synonyms HEL-75, HEL-S-122m
Description glutathione-disulfide reductase
Transcript NM_000637   
Expression
Putative miRNA Targets on GSR
3'UTR of GSR
(miRNA target sites are highlighted)
>GSR|NM_000637|3'UTR
   1 GAACCAGGAGACACGTGTGGCGGGCAGTGGGACCCATAGATCTTCTGAAATGAAACAAATAATCACATTGACTTACTGTT
  81 TGAGTTTTATGTATTTCTTTATTTTAATCAGGATCTTCTGATAGTGGAAATTTTTAGTACATAATAGAACTTATTTATGG
 161 AGTTAGAAATTTGTAGTGTTATCCAGGATTGATTTTCATTTGATCACATCTCACAGTAATTAATATTTTCAAGTTTTTTT
 241 TTTATTAACAGCTCTGTGCTAGTTTTTTTTTTCTGTTTTAGCCTCATCCCAAATATAAAGCTTTGTGAAGTACAATTAAC
 321 TTAATGTACTTGAATGAATAGAACTTGCTACTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCATTGCCCAGGC
 401 TGGAGTGCGGTGGTGCTATTTCAGCTCACCACAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTTAGCCTCCCGA
 481 ATAGCTGGAATTACAGGCACGCACCACCATGCCTGACTAATTTTGTATTTTTAGTAGACATGGGGTTTCTCCATGTTGGT
 561 CAGGCTGGTCTCAAACTCCCACCTTCAGGTGATCCGCCCACCTCGGCCTCCTGAGGTGCTGAGATTACAGGCGTGAGCCA
 641 CTGTGCCAGCTTGCTAATTTTCACAGAAGTTGATGGCAATTCTTCACATGTAAACAGTGCCAGTGCACAGAACCTTTATA
 721 TATTTTTTGAAGCCAGTACTGTGCTCTGCATATAACAAAGCTGCTTCAAGGATGAGACCTTTTTCTAAAAGCATGTAATG
 801 TGAGAAGCCGGCCTGCCTTATTTTCTTTTTTCTTTTTTAATGATTAAAAATAGTTTGTGGCAAGGCACGGTGGCTCAGGC
 881 CTGTAATTCTAGCACTTTGGGAGGCCGAGGCAGGAGGATTACTTGAGCCTACAAGTTTGAGGCCAGCATGCACAGCATAG
 961 CAAGACTGCATCTCTACAGAGAGTAAAAAAAATTACCCGAGTGTGGTGATGTGCATCTGTAATCTCAGCTACTTGGGAGG
1041 CTGAGGTGAGAGGATCACTTGAGCTTGGGTGAGGTGAGGCTGCAGTGAGTCCTGATCATGCTGCTGCACTCAATCTTGGA
1121 CAACAGAGCAAGACCCTGTCTCAAAAAAAAAAAAAAAAAATATATATATATATATATATTATTTTTATGAGGTGAAGTGC
1201 ATCAAACTTGGGAAAGATTTGAGGAGGCTGGGAACCTCCTGGAAAACCACTCCTTGAAGAAAGATATGAGAGACATTTAG
1281 AAGTGATTCCTGCTTTCAGAAGGAGGTGGATTCAAATACATCAAAAGTCCCTTCCTCTGCTAAGTGTTTATAGTTCAATG
1361 AATAATTTCAATATTTGTATGTGTTCTTGTCATTTTATTTTTTTCTGAAAAACTTCCAAAAATTTGAAAATAAAATTACA
1441 GCCTTTTCTTCTTATAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucUCCG--UCCAAGGACCUAGUa 5'
            ||||  ||||    |||||| 
Target 5' ggAGGCTGAGGTGAGAGGATCAc 3'
1036 - 1058 129.00 -19.10
2
miRNA  3' ucUCCGU-CCAAGGACCUAGUa 5'
            ||||| ||    ||| ||| 
Target 5' caAGGCACGG----TGGCTCAg 3'
861 - 878 121.00 -11.40
3
miRNA  3' ucUCCGUCCAAGGACCUAGUa 5'
            |||||||     ||||:| 
Target 5' cgAGGCAGGA----GGATTAc 3'
906 - 922 116.00 -17.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30172082 8 COSMIC
COSN31583967 15 COSMIC
COSN30547754 20 COSMIC
COSN31558146 21 COSMIC
COSN20076321 24 COSMIC
COSN30504037 30 COSMIC
COSN31540022 39 COSMIC
COSN14339897 40 COSMIC
COSN30146103 47 COSMIC
COSN30105581 68 COSMIC
COSN31516492 104 COSMIC
COSN31583621 147 COSMIC
COSN26438253 168 COSMIC
COSN27198914 262 COSMIC
COSN8079601 512 COSMIC
COSN20923753 633 COSMIC
COSN29810865 1032 COSMIC
COSN27880601 1453 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs915133836 1 dbSNP
rs989815814 13 dbSNP
rs746333168 14 dbSNP
rs779495845 15 dbSNP
rs1269909029 16 dbSNP
rs1189751431 19 dbSNP
rs757538187 20 dbSNP
rs763647057 21 dbSNP
rs373481457 22 dbSNP
rs752407262 24 dbSNP
rs767063881 27 dbSNP
rs560445388 37 dbSNP
rs200171779 39 dbSNP
rs369230085 40 dbSNP
rs1227267758 41 dbSNP
rs35768151 45 dbSNP
rs766391628 46 dbSNP
rs376582793 47 dbSNP
rs1307219338 48 dbSNP
rs762626909 50 dbSNP
rs1238709555 51 dbSNP
rs1043070487 57 dbSNP
rs1285022324 63 dbSNP
rs1031274834 69 dbSNP
rs1212847603 71 dbSNP
rs946084592 77 dbSNP
rs976521866 80 dbSNP
rs1181386365 83 dbSNP
rs1456965023 90 dbSNP
rs1408855740 97 dbSNP
rs1421095137 105 dbSNP
rs1157154920 107 dbSNP
rs1380002671 108 dbSNP
rs1435745211 111 dbSNP
rs965092617 115 dbSNP
rs913356131 121 dbSNP
rs1018039811 124 dbSNP
rs1233098668 125 dbSNP
rs1006538851 126 dbSNP
rs1374950640 134 dbSNP
rs1237497907 140 dbSNP
rs8191039 150 dbSNP
rs1348252092 158 dbSNP
rs1554991 166 dbSNP
rs1350422807 176 dbSNP
rs1277571954 187 dbSNP
rs537510398 198 dbSNP
rs1234793461 206 dbSNP
rs775863520 207 dbSNP
rs1441738272 211 dbSNP
rs1205194151 214 dbSNP
rs897993411 216 dbSNP
rs1233520270 219 dbSNP
rs188338725 220 dbSNP
rs769723357 226 dbSNP
rs1238051306 239 dbSNP
rs745646630 244 dbSNP
rs8191040 244 dbSNP
rs985683274 244 dbSNP
rs961414345 273 dbSNP
rs993849298 273 dbSNP
rs1372768975 275 dbSNP
rs1355703837 290 dbSNP
rs745982539 292 dbSNP
rs776626325 295 dbSNP
rs1045142048 306 dbSNP
rs948028340 317 dbSNP
rs1443950777 325 dbSNP
rs1024759364 329 dbSNP
rs1371317173 329 dbSNP
rs1442700031 330 dbSNP
rs1444544575 348 dbSNP
rs995344564 350 dbSNP
rs1337723819 351 dbSNP
rs1344123782 352 dbSNP
rs1435780394 352 dbSNP
rs1397397854 356 dbSNP
rs1215021256 359 dbSNP
rs1275045838 359 dbSNP
rs1320035861 364 dbSNP
rs1157454862 367 dbSNP
rs1417991781 368 dbSNP
rs1408007631 370 dbSNP
rs1332515827 371 dbSNP
rs1422637723 371 dbSNP
rs1477905805 371 dbSNP
rs1491024915 371 dbSNP
rs35555269 371 dbSNP
rs397893015 371 dbSNP
rs71823444 371 dbSNP
rs1178436160 372 dbSNP
rs1422296915 372 dbSNP
rs1471583522 381 dbSNP
rs1463567918 385 dbSNP
rs1169303871 396 dbSNP
rs576245359 402 dbSNP
rs1394644367 408 dbSNP
rs915257232 409 dbSNP
rs1321182972 411 dbSNP
rs1053690295 413 dbSNP
rs1013358894 416 dbSNP
rs1271818925 418 dbSNP
rs1486567101 419 dbSNP
rs1338299405 442 dbSNP
rs2551733 443 dbSNP
rs1283780376 444 dbSNP
rs1381680907 445 dbSNP
rs1138054 456 dbSNP
rs1317450687 457 dbSNP
rs1288006303 460 dbSNP
rs1054897479 463 dbSNP
rs1307739732 478 dbSNP
rs1265842778 479 dbSNP
rs1000704509 490 dbSNP
rs1193648305 491 dbSNP
rs756558112 500 dbSNP
rs976954120 501 dbSNP
rs1389609959 502 dbSNP
rs903772302 506 dbSNP
rs8191041 509 dbSNP
rs946104503 512 dbSNP
rs910945348 513 dbSNP
rs1415781551 515 dbSNP
rs1399323403 519 dbSNP
rs913296522 523 dbSNP
rs146973669 525 dbSNP
rs1356101536 527 dbSNP
rs944119784 534 dbSNP
rs747535348 536 dbSNP
rs911366325 539 dbSNP
rs553455623 540 dbSNP
rs1205995257 541 dbSNP
rs534116515 542 dbSNP
rs1487550820 544 dbSNP
rs1216451149 553 dbSNP
rs11552962 557 dbSNP
rs962571092 568 dbSNP
rs1443604033 579 dbSNP
rs972803607 582 dbSNP
rs1367437229 594 dbSNP
rs961100745 595 dbSNP
rs568218175 596 dbSNP
rs1416707352 597 dbSNP
rs10216724 600 dbSNP
rs1024662150 602 dbSNP
rs1377230398 603 dbSNP
rs570052585 604 dbSNP
rs1475990824 605 dbSNP
rs531396090 608 dbSNP
rs2551734 609 dbSNP
rs182562887 610 dbSNP
rs2551735 612 dbSNP
rs1033434143 618 dbSNP
rs1351901157 619 dbSNP
rs1239914887 628 dbSNP
rs1185742908 631 dbSNP
rs1484511271 632 dbSNP
rs552233138 633 dbSNP
rs1262468819 640 dbSNP
rs1217998528 643 dbSNP
rs758775349 644 dbSNP
rs1000692938 645 dbSNP
rs1437905131 646 dbSNP
rs370089677 650 dbSNP
rs1236008686 652 dbSNP
rs796525475 656 dbSNP
rs1234072551 664 dbSNP
rs1010633614 667 dbSNP
rs1276656463 669 dbSNP
rs747732351 686 dbSNP
rs1464472898 687 dbSNP
rs572203293 690 dbSNP
rs2551736 692 dbSNP
rs376725408 694 dbSNP
rs532433375 697 dbSNP
rs1333567737 700 dbSNP
rs1455919838 701 dbSNP
rs935350272 704 dbSNP
rs1446382899 705 dbSNP
rs1049920224 713 dbSNP
rs923830521 714 dbSNP
rs1040997301 715 dbSNP
rs1255939279 717 dbSNP
rs1247894811 718 dbSNP
rs931534610 722 dbSNP
rs1200021275 724 dbSNP
rs943841694 741 dbSNP
rs1457025399 746 dbSNP
rs1193939529 753 dbSNP
rs1165014721 756 dbSNP
rs1269198381 767 dbSNP
rs1431234229 768 dbSNP
rs911084307 772 dbSNP
rs1198022959 774 dbSNP
rs2551737 776 dbSNP
rs985205540 777 dbSNP
rs1467156451 778 dbSNP
rs1488980944 785 dbSNP
rs560554376 799 dbSNP
rs1172879342 803 dbSNP
rs8191042 809 dbSNP
rs189893412 810 dbSNP
rs1294342198 811 dbSNP
rs919693237 812 dbSNP
rs940285332 817 dbSNP
rs780670699 823 dbSNP
rs1301143187 833 dbSNP
rs1327502710 839 dbSNP
rs972769308 842 dbSNP
rs2551738 844 dbSNP
rs961087537 855 dbSNP
rs561413733 856 dbSNP
rs982358219 867 dbSNP
rs970851120 868 dbSNP
rs548572777 869 dbSNP
rs769634423 870 dbSNP
rs1467989223 872 dbSNP
rs1252380734 874 dbSNP
rs1487359822 883 dbSNP
rs1208987400 888 dbSNP
rs1262226513 889 dbSNP
rs1478753745 890 dbSNP
rs1214438137 892 dbSNP
rs1421484082 894 dbSNP
rs1477541830 895 dbSNP
rs1033422737 897 dbSNP
rs1012277169 898 dbSNP
rs893845273 906 dbSNP
rs142939376 907 dbSNP
rs1402394729 913 dbSNP
rs562606451 927 dbSNP
rs1009455056 928 dbSNP
rs1228426628 928 dbSNP
rs1314297202 931 dbSNP
rs901767707 935 dbSNP
rs1019589288 937 dbSNP
rs2551739 941 dbSNP
rs1243684812 942 dbSNP
rs902542269 944 dbSNP
rs545931781 946 dbSNP
rs1489149267 948 dbSNP
rs11552954 959 dbSNP
rs8191043 965 dbSNP
rs943977533 966 dbSNP
rs554763667 980 dbSNP
rs1049557868 981 dbSNP
rs1325936272 989 dbSNP
rs1164431712 990 dbSNP
rs898640906 993 dbSNP
rs185133657 998 dbSNP
rs753362892 999 dbSNP
rs991777204 1000 dbSNP
rs117945775 1002 dbSNP
rs939667397 1004 dbSNP
rs928326642 1005 dbSNP
rs1462294380 1008 dbSNP
rs1395020037 1011 dbSNP
rs1374526204 1013 dbSNP
rs1309546984 1014 dbSNP
rs926354731 1015 dbSNP
rs1138089 1021 dbSNP
rs1138092 1022 dbSNP
rs1237735498 1023 dbSNP
rs1285097509 1043 dbSNP
rs1453682739 1052 dbSNP
rs1395642425 1053 dbSNP
rs1348481447 1055 dbSNP
rs1138107 1057 dbSNP
rs1194318513 1072 dbSNP
rs1469911795 1080 dbSNP
rs1212228381 1082 dbSNP
rs182290262 1083 dbSNP
rs1138117 1084 dbSNP
rs1195383463 1087 dbSNP
rs1481083055 1096 dbSNP
rs970985878 1097 dbSNP
rs1239041482 1104 dbSNP
rs1253401345 1118 dbSNP
rs1441817710 1123 dbSNP
rs1232575803 1134 dbSNP
rs1347763285 1136 dbSNP
rs1380135394 1138 dbSNP
rs1304861139 1139 dbSNP
rs1415540403 1142 dbSNP
rs1178870189 1143 dbSNP
rs1356874492 1145 dbSNP
rs1446675817 1146 dbSNP
rs1235843945 1147 dbSNP
rs1444191281 1149 dbSNP
rs1374090529 1151 dbSNP
rs1023845338 1152 dbSNP
rs991374147 1153 dbSNP
rs866409942 1154 dbSNP
rs397717424 1155 dbSNP
rs199730579 1156 dbSNP
rs2911680 1157 dbSNP
rs1175515974 1158 dbSNP
rs3201906 1159 dbSNP
rs1491123637 1160 dbSNP
rs1004949759 1161 dbSNP
rs10558838 1161 dbSNP
rs1278914384 1161 dbSNP
rs1286902707 1161 dbSNP
rs1414443911 1161 dbSNP
rs1423717943 1161 dbSNP
rs1438375119 1161 dbSNP
rs1491429446 1161 dbSNP
rs202060962 1161 dbSNP
rs59845294 1161 dbSNP
rs67803604 1161 dbSNP
rs869129450 1161 dbSNP
rs1437760560 1162 dbSNP
rs1196918225 1163 dbSNP
rs1238338069 1163 dbSNP
rs1245396708 1163 dbSNP
rs1272586413 1163 dbSNP
rs1452507141 1163 dbSNP
rs1477983194 1163 dbSNP
rs958244165 1163 dbSNP
rs1362065797 1164 dbSNP
rs1425070786 1164 dbSNP
rs1169457713 1165 dbSNP
rs1334217362 1165 dbSNP
rs1476563336 1165 dbSNP
rs1406777145 1170 dbSNP
rs1321323701 1171 dbSNP
rs1181215277 1173 dbSNP
rs1032828274 1174 dbSNP
rs999641788 1176 dbSNP
rs1177002282 1180 dbSNP
rs1303615569 1180 dbSNP
rs1342393716 1180 dbSNP
rs1419839685 1182 dbSNP
rs1216906307 1190 dbSNP
rs1269711012 1200 dbSNP
rs1020754187 1202 dbSNP
rs554565893 1215 dbSNP
rs1288165538 1216 dbSNP
rs902510677 1232 dbSNP
rs1217918698 1250 dbSNP
rs1019662893 1258 dbSNP
rs1485586865 1263 dbSNP
rs965951589 1274 dbSNP
rs1281648457 1275 dbSNP
rs1213575842 1296 dbSNP
rs1411944019 1303 dbSNP
rs1191808263 1304 dbSNP
rs1008241621 1308 dbSNP
rs11552958 1310 dbSNP
rs1473572058 1314 dbSNP
rs1161097375 1319 dbSNP
rs1278405677 1323 dbSNP
rs1008220190 1330 dbSNP
rs889815572 1337 dbSNP
rs1160340352 1340 dbSNP
rs1337143583 1348 dbSNP
rs1291103013 1350 dbSNP
rs1317714109 1351 dbSNP
rs1341218184 1353 dbSNP
rs1450388995 1360 dbSNP
rs1028761294 1363 dbSNP
rs1359112058 1370 dbSNP
rs1241369655 1371 dbSNP
rs3594 1377 dbSNP
rs1314494069 1379 dbSNP
rs1352120508 1380 dbSNP
rs1205125523 1387 dbSNP
rs898577078 1389 dbSNP
rs1443653702 1397 dbSNP
rs1184896220 1401 dbSNP
rs1242176424 1403 dbSNP
rs192474167 1404 dbSNP
rs1158041638 1405 dbSNP
rs1160207037 1405 dbSNP
rs538747691 1419 dbSNP
rs1452966677 1422 dbSNP
rs1173097044 1423 dbSNP
rs746553094 1427 dbSNP
rs1037169285 1431 dbSNP
rs938282856 1434 dbSNP
rs1382272614 1435 dbSNP
rs926261399 1442 dbSNP
rs1375151388 1454 dbSNP
rs756212793 1454 dbSNP
rs1238888194 1455 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucuccGUCCAAGGACCUAGUa 5'
               ||||    ||||||| 
Target 5' ----aCAGG----UGGAUCAc 3'
1 - 13
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000221130.5 | 3UTR | ACAGGUGGAUCACCUGAGGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.631 4.7e-4 0.582 1.4e-3 24 Click to see details
GSE19783 ER+ ER+ breast cancer -0.659 7.9e-4 -0.786 2.0e-5 20 Click to see details
GSE19350 CNS germ cell tumors 0.492 5.2e-2 0.685 7.0e-3 12 Click to see details
GSE38226 Liver fibrosis 0.318 8.0e-2 0.240 1.5e-1 21 Click to see details
GSE17306 Multiple myeloma -0.176 1.1e-1 0.037 4.0e-1 49 Click to see details
GSE26953 Aortic valvular endothelial cells 0.241 1.3e-1 0.196 1.8e-1 24 Click to see details
GSE28260 Renal cortex and medulla -0.336 1.3e-1 -0.334 1.3e-1 13 Click to see details
GSE21849 B cell lymphoma 0.208 1.4e-1 0.343 3.4e-2 29 Click to see details
GSE14794 Lymphoblastoid cells 0.109 1.5e-1 0.032 3.8e-1 90 Click to see details
GSE17498 Multiple myeloma 0.154 1.7e-1 0.199 1.1e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells 0.188 2.0e-1 0.000 5.0e-1 23 Click to see details
GSE19783 ER- ER- breast cancer 0.096 2.0e-1 0.135 1.2e-1 79 Click to see details
GSE21687 Ependynoma primary tumors -0.075 2.8e-1 0.014 4.6e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.106 3.3e-1 -0.218 1.8e-1 20 Click to see details
GSE27834 Pluripotent stem cells 0.095 3.6e-1 0.082 3.8e-1 16 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.066 3.8e-1 0.042 4.2e-1 25 Click to see details
GSE32688 Pancreatic cancer 0.034 4.3e-1 -0.072 3.5e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.034 4.4e-1 -0.104 3.1e-1 25 Click to see details
GSE19536 Breast cancer 0.014 4.5e-1 0.009 4.6e-1 100 Click to see details
GSE19536 Breast cancer 0.014 4.5e-1 0.009 4.6e-1 100 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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