pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol INMT   
Synonyms TEMT
Description indolethylamine N-methyltransferase
Transcript NM_006774   
Expression
Putative miRNA Targets on INMT
3'UTR of INMT
(miRNA target sites are highlighted)
>INMT|NM_006774|3'UTR
   1 GCCAGGAGGGCCAGCCAGAGGTCTGGTCAGGCTGTGAGGCCTTGGCCATCTGTATGCTAGAGAGGGGTGAGGAATGGATA
  81 CTGTCTAACAGTCTCTGATTTCAACACTAACATTCCATCTTCTGAAATTCTGAGATTCTAACATCCTTGTTTTAGAATTC
 161 TAAGTTTCCAACATTCCTCATTCTAGGATCCTAGGAGTGGAATTTTCCATTTTCTAATATACTAAGCCTTACAGCTATCT
 241 TAGATGCGATCTGACTCCTGTGTGACTGTGGAGCACCCAGGGACGTGGTTTTAGAGTCTACCTAATATGTTAAGGACAAG
 321 GAAACCTCTGAGTCTACCTAATATGTTAAGGACAAGGAAACCTCTGGACAGTGGTATATTGGGGAATTTTTTTTTTTTTT
 401 TTGAGACGGAGTCTGGCTCTGTCACCCAGGCTAGAGTGCAATGGCACGATCTCGGCTCACTGCAAGCTCTGCGTCCTGGG
 481 TTGACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGAGCTCGCCACCACACCCAGCTAATTTTTTTTT
 561 TTTTTTTTTTATTTGAGACGGAGTTTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGACTCACTGCAAGCT
 641 CCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGACTACAGGCACGCGCCACCATGCCCGGC
 721 TAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTGGTGATCCACC
 801 CACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCACCCAGCCAGGGGGAATGTTCTATAACCAGCTCT
 881 GTAAAGGAAAAGCACTGATGTGTGGTAGTCACCAATTTCTGTGGTGTAAATACTCCCACCATGGTTGATTTCAAGCCACC
 961 AGTGGTTTAATAACCAGCTCATAAATCTCCTAAATATTTTACAGTTGACTCTCATGAGCTGATTGGAGTCAGCTGGAACA
1041 TACCACTGCCTCTAGACTAAGGTCAGCAGATTTAGCAAATACAGACTGCCCCAGTTCATTGAATTTTAGATAAATGAAAT
1121 AAATCTATAAGGTTAAGTATGTCCCCAGAACTGCATGGAACATGCTTAATCTAAACAATGATTTGTTGTTCACCTGAAAT
1201 TCAAATTTAGCTGGGTGTCCTGTATTTCATCTGGCAACCCTACTTCAGACCCAGGTGTAAGGTACATGGATGTGCTTTGG
1281 TCAAGGAATAGGCCAAGGCAGAGATCCATGCCTGCATGACTCAGTGGGTTTGGTGCACAGGCACACACCTCCACTTGTTA
1361 TATAACCTGTTTGTGTAAGTTCATACTTGGTCTGAGCCACTGTTGTCTGTAAAAGGTAATTGTCCTGCTAATGCTGTACA
1441 GGGGCTCTTGGGGTTCGGCTCAGCTCAACATGGCTTGACATGGTGGGCACACTGGCGCCCAGTAAGAGAGAGAGAGAGCC
1521 AAAGCTGTCCGTTTTGCAGATGGACAGGAAGGAGCCAGGACACAGCTCAGCTTGCTCACGCCCAGAGAGAGAAAAAGTTA
1601 AGCTGCTGACCCTGAAGGCAAGGGAGAGCAGGCTGCACAGCTGTGTGTGGAAGCCACGGGCTCAAGCAGCCAAGGCAGGG
1681 CGGACAGTGTGAGAGAGCTAGTGTAAGCTGTTGATGAGAGCTGTTGCTGAATAAAACCATATTCACCTGCCAAAAAAAAA
1761 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGGUCGGA-----GCGGGUCg 5'
            :||||:|     ||||||| 
Target 5' gcTCAGCTTGCTCACGCCCAGa 3'
1565 - 1586 151.00 -20.50
2
miRNA  3' acggucggAGCGGGUCg 5'
                  |||||||| 
Target 5' tcgctctgTCGCCCAGg 3'
586 - 602 145.00 -16.10
3
miRNA  3' acgGUCGGA--GCGGGUCg 5'
             ||  ||  ||||||| 
Target 5' gggCACACTGGCGCCCAGt 3'
1485 - 1503 144.00 -17.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM6393292 1 COSMIC
COSN30508399 3 COSMIC
COSN30191481 4 COSMIC
COSN30189041 14 COSMIC
COSN30746965 33 COSMIC
COSN28878688 68 COSMIC
COSN30508536 70 COSMIC
COSN23016983 81 COSMIC
COSN20515800 179 COSMIC
COSN15157350 472 COSMIC
COSN4933150 523 COSMIC
COSN1348313 572 COSMIC
COSN26149034 712 COSMIC
COSN29740231 758 COSMIC
COSN20741972 1120 COSMIC
COSN26806645 1329 COSMIC
COSN25786554 1352 COSMIC
COSN20868847 1440 COSMIC
COSN28545863 1532 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759877431 3 dbSNP
rs1301653603 7 dbSNP
rs753187501 11 dbSNP
rs1388773875 12 dbSNP
rs1294944200 15 dbSNP
rs921625151 22 dbSNP
rs1447591162 23 dbSNP
rs758520818 31 dbSNP
rs764129138 33 dbSNP
rs955419015 34 dbSNP
rs1342277597 43 dbSNP
rs751619800 45 dbSNP
rs1219244968 47 dbSNP
rs757443443 52 dbSNP
rs1455313190 62 dbSNP
rs370765580 65 dbSNP
rs566772555 80 dbSNP
rs6970396 81 dbSNP
rs1429994183 82 dbSNP
rs1194022691 84 dbSNP
rs1338618480 86 dbSNP
rs1256370528 87 dbSNP
rs1471085550 96 dbSNP
rs1010455621 100 dbSNP
rs1302947240 108 dbSNP
rs1042313344 112 dbSNP
rs974291525 120 dbSNP
rs1326883458 124 dbSNP
rs1391358682 125 dbSNP
rs1403454701 132 dbSNP
rs577529560 141 dbSNP
rs1433237518 143 dbSNP
rs779842969 144 dbSNP
rs1392919950 147 dbSNP
rs190839796 154 dbSNP
rs904689147 162 dbSNP
rs79258914 171 dbSNP
rs1178964775 174 dbSNP
rs1437178509 175 dbSNP
rs1034386339 178 dbSNP
rs1256755573 186 dbSNP
rs575404319 202 dbSNP
rs958755517 221 dbSNP
rs542794214 224 dbSNP
rs115948145 228 dbSNP
rs1024223544 233 dbSNP
rs1356075251 236 dbSNP
rs1277862770 246 dbSNP
rs1341654752 248 dbSNP
rs1283374092 249 dbSNP
rs75200877 260 dbSNP
rs6971062 263 dbSNP
rs1299139234 268 dbSNP
rs1419931626 270 dbSNP
rs532330867 281 dbSNP
rs1042960019 284 dbSNP
rs147722667 285 dbSNP
rs1469177049 286 dbSNP
rs996388259 288 dbSNP
rs868746920 293 dbSNP
rs1189955035 297 dbSNP
rs1317108708 306 dbSNP
rs1474157134 309 dbSNP
rs963228617 319 dbSNP
rs1030153492 320 dbSNP
rs1448974438 328 dbSNP
rs59180493 337 dbSNP
rs537145100 339 dbSNP
rs1008310848 341 dbSNP
rs1262852617 343 dbSNP
rs1285979160 344 dbSNP
rs921697222 345 dbSNP
rs1355304252 352 dbSNP
rs931681536 355 dbSNP
rs1402226971 362 dbSNP
rs1051436507 363 dbSNP
rs961328992 367 dbSNP
rs911554119 368 dbSNP
rs1399665811 373 dbSNP
rs6971218 375 dbSNP
rs6970815 377 dbSNP
rs1160336568 387 dbSNP
rs1283313069 387 dbSNP
rs569246314 387 dbSNP
rs58953785 387 dbSNP
rs879233413 387 dbSNP
rs1192773491 392 dbSNP
rs1401487566 393 dbSNP
rs1452361092 403 dbSNP
rs397969307 403 dbSNP
rs1330162728 404 dbSNP
rs1423951345 405 dbSNP
rs1303640543 406 dbSNP
rs1346885675 408 dbSNP
rs149804470 409 dbSNP
rs928798955 421 dbSNP
rs938467941 424 dbSNP
rs904719257 428 dbSNP
rs1269926671 430 dbSNP
rs1429632228 431 dbSNP
rs182944908 432 dbSNP
rs1331259552 433 dbSNP
rs1327351732 438 dbSNP
rs1052863619 441 dbSNP
rs1393736497 442 dbSNP
rs1171266763 447 dbSNP
rs1225111579 448 dbSNP
rs1309618731 449 dbSNP
rs1357679011 452 dbSNP
rs1055867593 454 dbSNP
rs894570468 455 dbSNP
rs946996846 456 dbSNP
rs1239370733 459 dbSNP
rs1043012633 460 dbSNP
rs578187274 471 dbSNP
rs1024297380 473 dbSNP
rs867379942 474 dbSNP
rs1348226722 477 dbSNP
rs1052073056 479 dbSNP
rs1005236849 481 dbSNP
rs539006319 486 dbSNP
rs1179110647 487 dbSNP
rs890287864 497 dbSNP
rs558306830 502 dbSNP
rs1443740830 505 dbSNP
rs12701025 510 dbSNP
rs1028797064 511 dbSNP
rs1367430206 512 dbSNP
rs1381036566 514 dbSNP
rs1015594916 517 dbSNP
rs1479952631 527 dbSNP
rs1408131630 530 dbSNP
rs1327681416 531 dbSNP
rs1354554069 533 dbSNP
rs953142374 534 dbSNP
rs987218070 535 dbSNP
rs995440228 537 dbSNP
rs1381541948 540 dbSNP
rs1245763547 542 dbSNP
rs1316153554 543 dbSNP
rs1359156199 547 dbSNP
rs1187604441 552 dbSNP
rs1255848874 552 dbSNP
rs1407947280 552 dbSNP
rs1476447232 552 dbSNP
rs1485172412 552 dbSNP
rs1491120348 552 dbSNP
rs373912701 552 dbSNP
rs867025732 552 dbSNP
rs67385022 553 dbSNP
rs1213254323 554 dbSNP
rs1314588909 555 dbSNP
rs1026927998 557 dbSNP
rs1272395655 558 dbSNP
rs1438421067 559 dbSNP
rs1206929867 561 dbSNP
rs1241576203 562 dbSNP
rs1290824297 562 dbSNP
rs1461025725 563 dbSNP
rs1344711906 564 dbSNP
rs1165657509 565 dbSNP
rs1463482831 565 dbSNP
rs1416309998 566 dbSNP
rs911572771 567 dbSNP
rs1184039379 568 dbSNP
rs945720941 568 dbSNP
rs58472657 571 dbSNP
rs977465757 571 dbSNP
rs10258337 572 dbSNP
rs56939384 573 dbSNP
rs1474389821 574 dbSNP
rs1390574028 575 dbSNP
rs1351207544 576 dbSNP
rs1419647336 577 dbSNP
rs1411190539 580 dbSNP
rs1232500246 581 dbSNP
rs1334088366 582 dbSNP
rs62446915 586 dbSNP
rs1452909413 588 dbSNP
rs1337804750 589 dbSNP
rs926247082 596 dbSNP
rs1342578370 597 dbSNP
rs1392965800 600 dbSNP
rs936213877 601 dbSNP
rs1270087429 607 dbSNP
rs537540012 608 dbSNP
rs1168695422 610 dbSNP
rs62446916 618 dbSNP
rs950159405 619 dbSNP
rs1045778333 620 dbSNP
rs866401926 621 dbSNP
rs1244767928 626 dbSNP
rs1213019133 627 dbSNP
rs1445024750 628 dbSNP
rs1192159230 642 dbSNP
rs1004234704 643 dbSNP
rs796695418 644 dbSNP
rs1173719823 645 dbSNP
rs899089343 650 dbSNP
rs994749016 651 dbSNP
rs376024682 652 dbSNP
rs1028870721 658 dbSNP
rs542704340 659 dbSNP
rs1318049310 662 dbSNP
rs1327594513 666 dbSNP
rs953174413 667 dbSNP
rs557397590 677 dbSNP
rs1018712102 682 dbSNP
rs967510788 683 dbSNP
rs977119421 684 dbSNP
rs1258025031 698 dbSNP
rs560983170 704 dbSNP
rs936294987 705 dbSNP
rs368580600 706 dbSNP
rs1489231859 707 dbSNP
rs1197117304 714 dbSNP
rs916107254 718 dbSNP
rs950232019 719 dbSNP
rs1239845590 721 dbSNP
rs1200921332 725 dbSNP
rs1305453216 730 dbSNP
rs761858627 730 dbSNP
rs1391230210 733 dbSNP
rs1361753889 736 dbSNP
rs1452595957 742 dbSNP
rs185761544 744 dbSNP
rs887201558 746 dbSNP
rs1386050332 750 dbSNP
rs1436208879 757 dbSNP
rs940065659 758 dbSNP
rs1038407608 769 dbSNP
rs1171552546 771 dbSNP
rs970737441 774 dbSNP
rs898488414 777 dbSNP
rs1179599798 778 dbSNP
rs980376118 780 dbSNP
rs1257969564 782 dbSNP
rs1189732035 798 dbSNP
rs1036300162 801 dbSNP
rs1278183780 802 dbSNP
rs7787251 807 dbSNP
rs960200477 808 dbSNP
rs1028903253 810 dbSNP
rs889008782 820 dbSNP
rs1356592162 821 dbSNP
rs1008756742 834 dbSNP
rs564966241 835 dbSNP
rs532427577 836 dbSNP
rs544227508 840 dbSNP
rs143680784 845 dbSNP
rs999006520 846 dbSNP
rs750503477 847 dbSNP
rs1032700934 850 dbSNP
rs191197777 853 dbSNP
rs931926292 856 dbSNP
rs1279935726 858 dbSNP
rs1418467288 861 dbSNP
rs991085300 871 dbSNP
rs1220205684 878 dbSNP
rs890290537 885 dbSNP
rs1194198544 888 dbSNP
rs940513666 898 dbSNP
rs375191922 909 dbSNP
rs1208127566 910 dbSNP
rs1336191401 930 dbSNP
rs1490487046 936 dbSNP
rs1037092096 941 dbSNP
rs897276747 954 dbSNP
rs138172252 959 dbSNP
rs1061641 964 dbSNP
rs1418157842 969 dbSNP
rs905852943 977 dbSNP
rs1002199352 978 dbSNP
rs1364763369 984 dbSNP
rs1433706638 987 dbSNP
rs79264536 1003 dbSNP
rs960502465 1011 dbSNP
rs988948949 1012 dbSNP
rs1020450606 1014 dbSNP
rs73685788 1015 dbSNP
rs1385216861 1019 dbSNP
rs140413488 1022 dbSNP
rs978501261 1029 dbSNP
rs1295365412 1037 dbSNP
rs1394353214 1041 dbSNP
rs940160492 1047 dbSNP
rs1188046247 1049 dbSNP
rs1038845190 1057 dbSNP
rs1254907772 1061 dbSNP
rs1061644 1064 dbSNP
rs932653497 1068 dbSNP
rs1341086398 1070 dbSNP
rs145521067 1079 dbSNP
rs889041383 1087 dbSNP
rs1008787911 1091 dbSNP
rs1314095951 1103 dbSNP
rs1227105601 1110 dbSNP
rs1040244090 1115 dbSNP
rs940591389 1116 dbSNP
rs1036175042 1129 dbSNP
rs568837285 1133 dbSNP
rs1349177345 1134 dbSNP
rs902995830 1141 dbSNP
rs1329346561 1142 dbSNP
rs1411449755 1159 dbSNP
rs1394683993 1160 dbSNP
rs998642636 1171 dbSNP
rs1033187592 1178 dbSNP
rs957093617 1184 dbSNP
rs1012538824 1190 dbSNP
rs1191776110 1194 dbSNP
rs1478016686 1196 dbSNP
rs865963956 1202 dbSNP
rs1233933839 1203 dbSNP
rs1207148099 1205 dbSNP
rs1249130243 1211 dbSNP
rs1436418164 1218 dbSNP
rs898999843 1220 dbSNP
rs767554038 1224 dbSNP
rs536276475 1230 dbSNP
rs554635220 1232 dbSNP
rs1239670249 1235 dbSNP
rs1348102388 1241 dbSNP
rs931429287 1249 dbSNP
rs1048427928 1251 dbSNP
rs971655239 1269 dbSNP
rs572877963 1288 dbSNP
rs539993908 1289 dbSNP
rs752748733 1290 dbSNP
rs777638817 1315 dbSNP
rs1036365630 1317 dbSNP
rs1384927204 1326 dbSNP
rs1333775966 1335 dbSNP
rs1307138308 1337 dbSNP
rs1435597624 1338 dbSNP
rs183111903 1340 dbSNP
rs1377482011 1346 dbSNP
rs908734691 1357 dbSNP
rs867790130 1359 dbSNP
rs7800792 1362 dbSNP
rs1409429781 1363 dbSNP
rs544451902 1365 dbSNP
rs1461581990 1367 dbSNP
rs748845452 1369 dbSNP
rs1267095800 1372 dbSNP
rs1251583168 1373 dbSNP
rs1473709503 1374 dbSNP
rs773746717 1378 dbSNP
rs747494487 1383 dbSNP
rs1281979284 1384 dbSNP
rs1207489051 1393 dbSNP
rs1402802022 1406 dbSNP
rs999949054 1409 dbSNP
rs1450719851 1411 dbSNP
rs1225426369 1427 dbSNP
rs932686110 1436 dbSNP
rs1326932867 1441 dbSNP
rs372092038 1457 dbSNP
rs187943915 1458 dbSNP
rs1383187404 1459 dbSNP
rs530564300 1471 dbSNP
rs1293307673 1472 dbSNP
rs944661509 1475 dbSNP
rs1447498445 1494 dbSNP
rs778584980 1497 dbSNP
rs192808105 1498 dbSNP
rs987184877 1503 dbSNP
rs1061678 1504 dbSNP
rs1259418666 1505 dbSNP
rs961972875 1505 dbSNP
rs1476385975 1506 dbSNP
rs1054177256 1509 dbSNP
rs775904936 1514 dbSNP
rs1179765175 1516 dbSNP
rs971946307 1532 dbSNP
rs1217285950 1541 dbSNP
rs920434714 1542 dbSNP
rs930437086 1544 dbSNP
rs747524502 1547 dbSNP
rs559633258 1548 dbSNP
rs35773690 1554 dbSNP
rs1227991291 1557 dbSNP
rs182187181 1564 dbSNP
rs1362860066 1567 dbSNP
rs1290758307 1569 dbSNP
rs1242943445 1571 dbSNP
rs1483758984 1576 dbSNP
rs906860870 1580 dbSNP
rs1003156712 1581 dbSNP
rs1428427914 1582 dbSNP
rs1367122183 1593 dbSNP
rs1164462371 1598 dbSNP
rs937408392 1600 dbSNP
rs1016274878 1603 dbSNP
rs895797625 1611 dbSNP
rs1425787871 1616 dbSNP
rs1010501922 1622 dbSNP
rs1246815012 1626 dbSNP
rs1214247774 1627 dbSNP
rs1469730979 1629 dbSNP
rs1041953221 1630 dbSNP
rs367651451 1631 dbSNP
rs1308340030 1643 dbSNP
rs1359561902 1646 dbSNP
rs1226343812 1648 dbSNP
rs1364559994 1650 dbSNP
rs974652165 1658 dbSNP
rs571774748 1659 dbSNP
rs1443786303 1663 dbSNP
rs1389180972 1668 dbSNP
rs34268545 1678 dbSNP
rs67230221 1678 dbSNP
rs1138790 1681 dbSNP
rs565749579 1681 dbSNP
rs13307741 1682 dbSNP
rs551269183 1683 dbSNP
rs985521253 1707 dbSNP
rs1279555507 1710 dbSNP
rs1389044609 1715 dbSNP
rs1193659298 1720 dbSNP
rs1455569279 1721 dbSNP
rs560559883 1724 dbSNP
rs944048104 1737 dbSNP
rs918420636 1746 dbSNP
rs76842935 1747 dbSNP
rs777082040 1749 dbSNP
rs1252787249 1752 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001199219 | 3UTR | UUUUUUUAUUUGAGACGGAGUUUCGCUCUGUCGCCCAGGCUGGAGUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001199219 | 3UTR | UGAGACGGAGUUUCGCUCUGUCGCCCAGGCUGGAGUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000013222.5 | 3UTR | GUAAGAGAGAGAGAGAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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