miRTarBase - #MIRT650971


—
pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol STARD3NL   
Synonyms MENTHO
Description STARD3 N-terminal like
Transcript NM_032016   
Expression
Putative miRNA Targets on STARD3NL
3'UTR of STARD3NL
(miRNA target sites are highlighted)		 
>STARD3NL|NM_032016|3'UTR
   1 GTACTACTTTTGTTAAATGTGAAAAACCCTCACAGAAAGTCATCGAGGCAAAAAGAGGCAGGCAGTGGAGTCTCCCTGTC
  81 GACAGTAAAGTTGAAATGGTGACGTCCACTGCTGGCTTTATTGAACAGCTAATAAAGATTTATTTATTGTAATACCTCAC
 161 AGACGTTGTACCATATCCATGCACATTTAGTTGCCTGCCTGTGGCTGGTAAGGTAATGTCATGATTCATCCTCTCTTCAG
 241 TGAGACTGAGCCTGATGTGTTAACAAATAGGTGAAGAAAGTCTTGTGCTGTATTCCTAATCAAAAGACTTAATATATTGA
 321 AGTAACACTTTTTTAGTAAGCAAGATACCTTTTTATTTCAATTCACAGAATGGAATTTTTTTGTTTCATGTCTCAGATTT
 401 ATTTTGTATTTCTTTTTTAACACTCTACATTTCCCTTGTTTTTTAACTCATGCACATGTGCTCTTTGTACAGTTTTAAAA
 481 AGTGTAATAAAATCTGACATGTCAATGTGGCTAGTTTTATTTTTCTTGTTTTGCATTATGTGTATGGCCTGAAGTGTTGG
 561 ACTTGCAAAAGGGGAAGAAAGGAATTGCGAATACATGTAAAATGTCACCAGACATTTGTATTATTTTTATCATGAAATCA
 641 TGTTTTTCTCTGATTGTTCTGAAATGTTCTAAATACTCTTATTTTGAATGCACAAAATGACTTAAACCATTCATATCATG
 721 TTTCCTTTGCGTTCAGCCAATTTCAATTAAAATGAACTAAATTATAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugCCGAU--CAC--CUG---GUCCACUUCa 5'
            | ||:  |||   ||   :|||||||| 
Target 5' gaGCCTGATGTGTTAACAAATAGGTGAAGa 3'
 248 - 277 149.00 -15.60
2 
miRNA  3' ugcCGAUC---ACCUGGUCCACUUCa 5'
             |:|:|   || |  ||| |||| 
Target 5' agtGTTGGACTTGCAAAAGGGGAAGa 3'
 553 - 578 124.00 -11.90
3 
miRNA  3' ugccgaUCACCUGGUCCACUUCa 5'
                ||| ||   ||||| | 
Target 5' cagtaaAGTTGAAATGGTGACGt 3'
 83 - 105 121.00 -10.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN6880599 165 COSMIC
COSN29568266 189 COSMIC
COSN21672475 383 COSMIC
COSN9987668 434 COSMIC
COSN32112915 975 COSMIC
COSN17534621 980 COSMIC
COSN31483295 1161 COSMIC
COSN30109731 1173 COSMIC
COSN31567636 1187 COSMIC
COSN28738319 1214 COSMIC
COSN31544034 1216 COSMIC
COSN26538166 1260 COSMIC
COSN8800624 1362 COSMIC
COSN15196465 1570 COSMIC
COSN31522670 1573 COSMIC
COSN9987669 1662 COSMIC
COSN6880600 1765 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1389553400 7 dbSNP
rs759438361 13 dbSNP
rs1296023399 16 dbSNP
rs575090325 22 dbSNP
rs1242455231 27 dbSNP
rs754009282 29 dbSNP
rs1267180034 34 dbSNP
rs1360120921 36 dbSNP
rs1215229681 38 dbSNP
rs752324265 39 dbSNP
rs776008338 40 dbSNP
rs1186743386 41 dbSNP
rs111969883 42 dbSNP
rs1262801454 47 dbSNP
rs751097516 48 dbSNP
rs993687086 51 dbSNP
rs188168037 61 dbSNP
rs1326432879 67 dbSNP
rs574659936 68 dbSNP
rs970796680 80 dbSNP
rs1412677074 98 dbSNP
rs1334821431 100 dbSNP
rs980883078 101 dbSNP
rs1476287093 103 dbSNP
rs180885054 105 dbSNP
rs111786320 109 dbSNP
rs958084168 111 dbSNP
rs560384612 121 dbSNP
rs1442583654 126 dbSNP
rs1464445336 144 dbSNP
rs990446534 145 dbSNP
rs1266310340 160 dbSNP
rs914504290 161 dbSNP
rs1322523954 162 dbSNP
rs970728142 183 dbSNP
rs372607405 191 dbSNP
rs1226917923 192 dbSNP
rs945832097 196 dbSNP
rs1281105493 201 dbSNP
rs1365350912 207 dbSNP
rs977279763 226 dbSNP
rs1222803992 233 dbSNP
rs923141330 237 dbSNP
rs1435009864 248 dbSNP
rs1263750863 249 dbSNP
rs1363723557 258 dbSNP
rs2191313 264 dbSNP
rs1050155029 277 dbSNP
rs1196841530 286 dbSNP
rs1348894549 290 dbSNP
rs1272470022 295 dbSNP
rs1162281361 297 dbSNP
rs1438639642 301 dbSNP
rs765286371 302 dbSNP
rs34736781 310 dbSNP
rs888756755 310 dbSNP
rs1187769157 312 dbSNP
rs1447568546 316 dbSNP
rs1254866792 320 dbSNP
rs1192952841 323 dbSNP
rs959451946 328 dbSNP
rs1245320754 331 dbSNP
rs941717457 340 dbSNP
rs1219654596 348 dbSNP
rs1038322395 351 dbSNP
rs1480336007 352 dbSNP
rs898078374 355 dbSNP
rs10252428 357 dbSNP
rs1432160281 362 dbSNP
rs1481099784 367 dbSNP
rs910049246 375 dbSNP
rs1025137278 378 dbSNP
rs1304086825 379 dbSNP
rs1165654943 384 dbSNP
rs565391852 391 dbSNP
rs1291359372 392 dbSNP
rs1443918152 409 dbSNP
rs972946453 411 dbSNP
rs1167704289 415 dbSNP
rs761281295 421 dbSNP
rs1330534858 431 dbSNP
rs1427615398 442 dbSNP
rs922829134 445 dbSNP
rs530782046 453 dbSNP
rs1033778216 454 dbSNP
rs758406956 460 dbSNP
rs1283779886 465 dbSNP
rs550927941 466 dbSNP
rs1347321646 470 dbSNP
rs1051402461 472 dbSNP
rs1484148729 473 dbSNP
rs989499113 474 dbSNP
rs1252867836 483 dbSNP
rs767044794 484 dbSNP
rs1482289442 486 dbSNP
rs1258223400 487 dbSNP
rs1234606189 496 dbSNP
rs967312144 497 dbSNP
rs1312186213 498 dbSNP
rs977337397 502 dbSNP
rs750026206 505 dbSNP
rs1298542504 513 dbSNP
rs774534519 514 dbSNP
rs1350694258 516 dbSNP
rs1307051505 519 dbSNP
rs923088843 521 dbSNP
rs1404092976 529 dbSNP
rs1303284001 535 dbSNP
rs1288074382 539 dbSNP
rs1465474238 542 dbSNP
rs755802159 549 dbSNP
rs1174010028 551 dbSNP
rs1473629357 556 dbSNP
rs766018597 570 dbSNP
rs1181742690 571 dbSNP
rs1223706759 573 dbSNP
rs893628765 575 dbSNP
rs954562003 579 dbSNP
rs561163205 582 dbSNP
rs753657038 591 dbSNP
rs1190341153 597 dbSNP
rs1483195791 598 dbSNP
rs761953245 615 dbSNP
rs530415174 618 dbSNP
rs1318703704 620 dbSNP
rs1020898992 622 dbSNP
rs546937736 648 dbSNP
rs368731703 652 dbSNP
rs1226187247 656 dbSNP
rs566679084 657 dbSNP
rs1037367031 662 dbSNP
rs1341956847 664 dbSNP
rs1169269558 673 dbSNP
rs1395285041 677 dbSNP
rs1383015201 687 dbSNP
rs1399936751 692 dbSNP
rs1322488035 697 dbSNP
rs918948355 709 dbSNP
rs1303564118 722 dbSNP
rs754781601 723 dbSNP
rs1046701434 734 dbSNP
rs1370468173 737 dbSNP
rs959761873 746 dbSNP
rs984204261 756 dbSNP
rs1254618473 759 dbSNP
rs1017549405 773 dbSNP
rs1465798370 774 dbSNP
rs1342334889 777 dbSNP
rs906672236 784 dbSNP
rs961537812 785 dbSNP
rs972835703 788 dbSNP
rs1317603454 790 dbSNP
rs1002381474 792 dbSNP
rs1338504560 811 dbSNP
rs1055175253 812 dbSNP
rs1299651207 818 dbSNP
rs1435723314 819 dbSNP
rs893888280 826 dbSNP
rs1011442362 827 dbSNP
rs1399069606 828 dbSNP
rs955612956 829 dbSNP
rs1164063679 831 dbSNP
rs778966961 835 dbSNP
rs1383768076 836 dbSNP
rs10226230 838 dbSNP
rs1359003507 847 dbSNP
rs1186075290 851 dbSNP
rs1452852837 854 dbSNP
rs998704476 855 dbSNP
rs551822988 862 dbSNP
rs954510051 863 dbSNP
rs183949970 864 dbSNP
rs985927162 865 dbSNP
rs1341333964 869 dbSNP
rs778012509 870 dbSNP
rs537572743 875 dbSNP
rs1332912370 876 dbSNP
rs1205031096 880 dbSNP
rs1330792218 881 dbSNP
rs1363997647 887 dbSNP
rs1310202412 888 dbSNP
rs750360951 888 dbSNP
rs973586285 894 dbSNP
rs554540262 897 dbSNP
rs74578651 902 dbSNP
rs1478688878 903 dbSNP
rs536924443 909 dbSNP
rs1197617479 910 dbSNP
rs1240835871 917 dbSNP
rs1489708526 923 dbSNP
rs928971780 925 dbSNP
rs1253578378 933 dbSNP
rs776773950 939 dbSNP
rs928205227 940 dbSNP
rs1272303600 942 dbSNP
rs377233640 943 dbSNP
rs534031840 951 dbSNP
rs1055293224 960 dbSNP
rs1232674585 962 dbSNP
rs895135566 965 dbSNP
rs1005937195 970 dbSNP
rs1410753887 975 dbSNP
rs1157918002 977 dbSNP
rs1327353968 978 dbSNP
rs1016993001 979 dbSNP
rs1385599299 982 dbSNP
rs1383929494 985 dbSNP
rs1403606849 986 dbSNP
rs961408446 995 dbSNP
rs554117388 998 dbSNP
rs994329068 1003 dbSNP
rs1413652782 1005 dbSNP
rs1472098629 1006 dbSNP
rs56141476 1007 dbSNP
rs2286691 1009 dbSNP
rs546040338 1010 dbSNP
rs1042883612 1013 dbSNP
rs1290369293 1020 dbSNP
rs1321519001 1020 dbSNP
rs1229243245 1023 dbSNP
rs1317484086 1029 dbSNP
rs552085749 1037 dbSNP
rs1238792625 1043 dbSNP
rs911433667 1047 dbSNP
rs964425338 1049 dbSNP
rs1261755193 1055 dbSNP
rs998147111 1065 dbSNP
rs1467721560 1066 dbSNP
rs1390198210 1073 dbSNP
rs1353503949 1079 dbSNP
rs76535148 1081 dbSNP
rs1240702660 1087 dbSNP
rs1236767286 1093 dbSNP
rs1460517023 1095 dbSNP
rs1183814776 1096 dbSNP
rs954623191 1097 dbSNP
rs775935583 1101 dbSNP
rs915003810 1110 dbSNP
rs945101868 1111 dbSNP
rs1007463486 1114 dbSNP
rs1209497508 1120 dbSNP
rs1042286181 1124 dbSNP
rs1282462603 1125 dbSNP
rs1017421475 1126 dbSNP
rs1357514257 1127 dbSNP
rs1284054264 1132 dbSNP
rs1364271592 1133 dbSNP
rs1320601528 1135 dbSNP
rs1433751565 1139 dbSNP
rs1455303347 1148 dbSNP
rs1174254169 1151 dbSNP
rs1166485615 1153 dbSNP
rs1405407946 1156 dbSNP
rs570340781 1159 dbSNP
rs973149952 1169 dbSNP
rs1161508778 1172 dbSNP
rs370130385 1175 dbSNP
rs1338934416 1176 dbSNP
rs1248614305 1177 dbSNP
rs534658215 1178 dbSNP
rs1485598620 1195 dbSNP
rs1026493049 1207 dbSNP
rs8163 1214 dbSNP
rs1308185389 1216 dbSNP
rs895033002 1216 dbSNP
rs1005558734 1217 dbSNP
rs9490 1221 dbSNP
rs1344885419 1224 dbSNP
rs1299018500 1225 dbSNP
rs189462480 1226 dbSNP
rs1359254984 1231 dbSNP
rs530045527 1232 dbSNP
rs148612877 1234 dbSNP
rs1029812851 1235 dbSNP
rs991501624 1251 dbSNP
rs1479472803 1253 dbSNP
rs915389321 1255 dbSNP
rs916334692 1261 dbSNP
rs1390660924 1269 dbSNP
rs1167900079 1273 dbSNP
rs372548187 1274 dbSNP
rs1417457232 1276 dbSNP
rs1193038883 1281 dbSNP
rs1488911570 1282 dbSNP
rs955579305 1300 dbSNP
rs1042438881 1309 dbSNP
rs1194964611 1314 dbSNP
rs902596869 1316 dbSNP
rs1275889974 1336 dbSNP
rs376967816 1354 dbSNP
rs1420700754 1355 dbSNP
rs1306324455 1365 dbSNP
rs560430779 1373 dbSNP
rs1018529008 1378 dbSNP
rs142206522 1379 dbSNP
rs934113673 1381 dbSNP
rs1219350888 1382 dbSNP
rs1344436122 1406 dbSNP
rs957824303 1413 dbSNP
rs1051036390 1434 dbSNP
rs1411370973 1437 dbSNP
rs889810161 1441 dbSNP
rs1007409751 1444 dbSNP
rs1480764735 1452 dbSNP
rs15007 1464 dbSNP
rs1261844049 1474 dbSNP
rs1460382146 1479 dbSNP
rs201437036 1481 dbSNP
rs766035620 1498 dbSNP
rs995082647 1502 dbSNP
rs1026186939 1504 dbSNP
rs10696 1505 dbSNP
rs966474910 1506 dbSNP
rs1197539220 1508 dbSNP
rs1473731082 1509 dbSNP
rs950440677 1510 dbSNP
rs150802710 1515 dbSNP
rs1479928335 1520 dbSNP
rs1258323718 1528 dbSNP
rs753889612 1550 dbSNP
rs1034666384 1556 dbSNP
rs1322234365 1557 dbSNP
rs1200580014 1558 dbSNP
rs1260791871 1562 dbSNP
rs991022552 1569 dbSNP
rs1350791819 1579 dbSNP
rs916535767 1591 dbSNP
rs1389492946 1593 dbSNP
rs941272667 1596 dbSNP
rs1038356306 1599 dbSNP
rs1299000295 1601 dbSNP
rs959045331 1602 dbSNP
rs139220377 1611 dbSNP
rs531431649 1613 dbSNP
rs547982142 1614 dbSNP
rs1470304732 1617 dbSNP
rs1405431728 1619 dbSNP
rs1174437522 1634 dbSNP
rs568007411 1640 dbSNP
rs753476708 1641 dbSNP
rs116033996 1650 dbSNP
rs10945 1661 dbSNP
rs1465205182 1664 dbSNP
rs1182957085 1666 dbSNP
rs765149671 1668 dbSNP
rs182508412 1670 dbSNP
rs539776293 1679 dbSNP
rs1305308246 1684 dbSNP
rs1329372901 1689 dbSNP
rs1259805640 1691 dbSNP
rs1203344363 1694 dbSNP
rs1051145940 1708 dbSNP
rs778930684 1713 dbSNP
rs1323287478 1714 dbSNP
rs1313243063 1716 dbSNP
rs942704664 1725 dbSNP
rs1038914300 1730 dbSNP
rs1334754258 1733 dbSNP
rs1219996821 1734 dbSNP
rs1437413582 1742 dbSNP
rs899077140 1744 dbSNP
rs1385884286 1745 dbSNP
rs1158228657 1747 dbSNP
rs1268043490 1750 dbSNP
rs1022001383 1758 dbSNP
rs1166003394 1768 dbSNP
rs1444540882 1775 dbSNP
rs1241865233 1782 dbSNP
rs966380105 1783 dbSNP
rs1417422196 1798 dbSNP
rs1428063696 1806 dbSNP
rs977729707 1808 dbSNP
rs1202996743 1809 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugccgaucaccUGGUCCACUUCa 5'
                     | :|||||||| 
Target 5' -----------AAUAGGUGAAGa 3'
 		1 - 12
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000009041.7 | 3UTR | AAUAGGUGAAGAAAGUCUUGUGCUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
Click to see details
138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

Error report submission