miRTarBase - #MIRT651181


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pre-miRNA Information
pre-miRNA hsa-mir-2909   
Genomic Coordinates chr17: 37033745 - 37033813
Description Homo sapiens miR-2909 stem-loop
Comment This miRNA was referred to as hmiR-che-1 in .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2909
Sequence 4| GUUAGGGCCAACAUCUCUUGG |24
Evidence Experimental
Experiments QPCR
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs187707102 7 dbSNP
rs1375183104 8 dbSNP
rs1174848003 11 dbSNP
rs576577155 21 dbSNP
Putative Targets

Gene Information
Gene Symbol ZNF281   
Synonyms ZBP-99, ZNP-99
Description zinc finger protein 281
Transcript NM_012482   
Expression
Putative miRNA Targets on ZNF281
3'UTR of ZNF281
(miRNA target sites are highlighted)		 
>ZNF281|NM_012482|3'UTR
   1 GGTCCCAAAAGTGGCCAGGCTGGAGGTCTTCTAATGTAATTTTGTTTTATTTTGAGAACACTGCCATTGGAATGTTTCTA
  81 CACGATCCTATTAAGAATAATGTGATGCCCTTTCAATGCAACTTTTCATATTTAGTTTATTTTGTTAGCGTGATTTTAGC
 161 TCTGTTTGTATTATGATTTTTAATCAAAATCAATAGATTAAAAATAGTTTGACATTCAAAGTGACAATGTTTAGCAATCA
 241 AATTTACATGTATAGATCGTCAGGGAATAGCCCAAATGTTTTAAACGCAAAAAAAAAGACAAAAAAAAACCAAAAAAAAA
 321 AAACCTACAAAAAAAACTTTGTTGCTAGGATTAAGGTTATTCTAATTGCTTTACTCTCAGGAAAGTGTAATAACGCATGG
 401 GAATTCTGTACGTTATCACTGTAATGGAATATCCAATTTACAGATAGTATGATATACATTTCATCATTTAAGTAAGGGAT
 481 CGAAAACATTTCAAATTGCTCTATCTGGGCTGATAGACATTTCGTCATTTAAGTAAGGGATCGAAGACATTTCAAATTGC
 561 TATCTCCATCTGGGCTGATCCAAAATTCTGAGATTGTTGGCTACCTATATTTTGTTGCAGCTTTTAAATGTACTCTGAAC
 641 TTCCAAACCACATTCATTCCAGCCTGGTAGAACAAATATTCTTGGATCTTTGATCAAAGCCTGGAATGATAGCTTTAATA
 721 AAAGAAGGAAAAAAAAAAAGCACCCTCTCTTGATCTCAACTGTAACAAGGCTGTAATTCCATCAAGCGATTCTACTGACA
 801 TCTAGTACAGTGTTGAAGCCCAAGTGGTTGGCTGGTTCCAGTATTAGAACTCAAGTTGAAATTATATGATTAACTGAAAT
 881 TTGGGGCATGCATTATTTATTATACATGGCCTACAACGGTTCTGTCTGCGCTGTTACGTATTACCTACACTTCTGGGTTT
 961 TTTTGTTCTTGTTCTCAGCCTCTCTTTAAGAGTTCTTGGGCCTTCCTTTTCCCTCTTTCTATTTTAACAGTTTTAATTTT
1041 AGAACCATTTACATTCCAGTAGGTAATTCACTATGCGCTTTATATGCCTTAGGGCATCCAAATAAAAAACAATAGGGTAA
1121 ACATCCCCAAAACCCACCTTTAAAAAAAAAAAAACCCATACAGATTTCCATATGTAATAAAACCCCGTGTTCTTGGATAG
1201 ATATTAATAAGGTTGTAATTCCAACTGGTGACATAACTCCTGTGAGGGATAAGAATGTGTCTGCTTATAGTAATAACATC
1281 AGAACCTCTTTGTGAAATTGCGGCCTTTAATGTACATTTTAATGAAAGGGTGCATTAGTATTGTACAGGGGTCTTGTAAA
1361 GTCATCAAAACTTGCTATGAACTCTAATTGCCATTTGAAGCTACTGATTGGCAGTGGCTCTACTCTAAAACTGCTTTTTA
1441 GCAATTGTATTTTTTTCCTGATTATATTTTTTAATGTACTTTGATGTTTATGCTGATGAGTTTTTTATGTACTTTTGGTG
1521 ATGTTTCAGTCTTATGTACTCTTCTGACGTCAGAAAAGTACCACTGGTTGTTTGCAGTCTTATTGTGTAATCAGCCTACC
1601 GCAGGCTTCCATGTATAATAAAGTAATTAATATTGTGCAAGTGTAAAACACTTCTGTTATAAAAGCAGTGTTTGGAAAAT
1681 AAGAAATATTAAAAATGGTTACAAAGTATTAGTTAATTTCCTTTTCCCACTTTCCTCCCTTTAGCTTTAGCAGCTAAAGG
1761 GTCACCAACTTGTCATTGCAAGATTCTTAGAAAATGTACTTAATCTTAAATACGCTGAGTACTAAAAAGTGTTTATTTCT
1841 TATTTCAGTAAGTGCGGTAAGTTCTATTGAGTACAGAGTACAAGCTGTAATCAAAGGATGGAGAGGACCTTTACCACTGT
1921 ATCTCTTAAGCTGTATGATTTTTCTCCAGTTTGTTTTATACAGGTTTTGAATTTCTTTAACTTTTATTGTGTGTACTGAA
2001 TACTGCATATGTATTATTCTGATTGTTTGCTCTAGTTTACTACCAATAAAAGTCCTGTTAATCACAAGATTAAAAAAAAA
2081 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gguucuCU-ACAACCGGGAUUg 5'
                || |||| ||:|||: 
Target 5' tattctGATTGTTTGCTCTAGt 3'
 2015 - 2036 127.00 -9.50
2 
miRNA  3' gguuCUCUACAACCGGGAUUg 5'
              |: ||| | ||::||| 
Target 5' gcctGGAATGATAGCTTTAAt 3'
 699 - 719 125.00 -9.50
3 
miRNA  3' gguUCUCUACAACCGGGAUUg 5'
             ||:||   | |||| || 
Target 5' gtcAGGGA--ATAGCCCAAAt 3'
 259 - 277 118.00 -9.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30458048 20 COSMIC
COSN30162069 60 COSMIC
COSN31560073 64 COSMIC
COSN30512994 67 COSMIC
COSN30173795 83 COSMIC
COSN30175395 87 COSMIC
COSN30495969 107 COSMIC
COSN30419820 185 COSMIC
COSN6018799 197 COSMIC
COSN31528508 212 COSMIC
COSN31522289 222 COSMIC
COSN31609565 258 COSMIC
COSN31553423 286 COSMIC
COSN30539868 288 COSMIC
COSN29007923 311 COSMIC
COSN15662061 312 COSMIC
COSN32061574 329 COSMIC
COSN26644235 341 COSMIC
COSN17761791 351 COSMIC
COSN26574907 355 COSMIC
COSN30544791 377 COSMIC
COSN26555898 378 COSMIC
COSN31544099 395 COSMIC
COSN31608364 523 COSMIC
COSN29467877 524 COSMIC
COSN30544824 553 COSMIC
COSN27396117 728 COSMIC
COSN27462581 729 COSMIC
COSN29357844 959 COSMIC
COSN28939445 965 COSMIC
COSN21431554 974 COSMIC
COSN7197820 990 COSMIC
COSN16449829 1383 COSMIC
COSN26713063 1493 COSMIC
COSN8428286 1760 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1162759417 5 dbSNP
rs1425199419 7 dbSNP
rs771841506 11 dbSNP
rs1259770831 17 dbSNP
rs748135498 17 dbSNP
rs1374201308 18 dbSNP
rs774315324 20 dbSNP
rs1166474518 21 dbSNP
rs573995191 23 dbSNP
rs1183525332 25 dbSNP
rs899692165 31 dbSNP
rs1214275850 32 dbSNP
rs1393331573 33 dbSNP
rs377661439 33 dbSNP
rs1034066469 37 dbSNP
rs781078928 38 dbSNP
rs1285368369 39 dbSNP
rs1222263980 41 dbSNP
rs757561925 48 dbSNP
rs534302212 54 dbSNP
rs1226614902 55 dbSNP
rs566897310 64 dbSNP
rs1334542168 65 dbSNP
rs1041623941 66 dbSNP
rs949789981 78 dbSNP
rs1361408198 80 dbSNP
rs1222768919 81 dbSNP
rs551894990 83 dbSNP
rs540071956 84 dbSNP
rs1489625956 89 dbSNP
rs1218106299 96 dbSNP
rs1010331128 97 dbSNP
rs1191679412 100 dbSNP
rs891688737 104 dbSNP
rs1179769864 107 dbSNP
rs1459484768 108 dbSNP
rs1421774933 117 dbSNP
rs1289457397 127 dbSNP
rs1239411047 128 dbSNP
rs916921868 132 dbSNP
rs1193558519 140 dbSNP
rs569449684 149 dbSNP
rs1055977130 159 dbSNP
rs1246507447 162 dbSNP
rs201032582 164 dbSNP
rs1356777928 170 dbSNP
rs937096000 174 dbSNP
rs1260743016 175 dbSNP
rs1485292434 181 dbSNP
rs920318597 185 dbSNP
rs1245548936 190 dbSNP
rs549327975 201 dbSNP
rs1240706511 207 dbSNP
rs1039095054 212 dbSNP
rs1441717083 215 dbSNP
rs1160187164 217 dbSNP
rs974212942 227 dbSNP
rs962815111 232 dbSNP
rs1156721072 237 dbSNP
rs1047690565 249 dbSNP
rs1379003985 252 dbSNP
rs1335764761 254 dbSNP
rs1326846848 258 dbSNP
rs766940206 259 dbSNP
rs929314460 266 dbSNP
rs1307345377 273 dbSNP
rs1403061954 283 dbSNP
rs1304756215 286 dbSNP
rs1433127372 287 dbSNP
rs1394788135 288 dbSNP
rs920816405 289 dbSNP
rs1159643558 296 dbSNP
rs780680157 297 dbSNP
rs1177970390 298 dbSNP
rs3210270 298 dbSNP
rs1250139788 300 dbSNP
rs3204322 300 dbSNP
rs1181771444 301 dbSNP
rs1430079460 301 dbSNP
rs1175688575 302 dbSNP
rs1470200232 302 dbSNP
rs1436704772 306 dbSNP
rs1256275257 309 dbSNP
rs1223437948 310 dbSNP
rs1284565669 310 dbSNP
rs1372094260 310 dbSNP
rs1389350647 310 dbSNP
rs1463369318 310 dbSNP
rs551314475 310 dbSNP
rs926817624 310 dbSNP
rs1201748653 311 dbSNP
rs1205605014 312 dbSNP
rs1484491433 312 dbSNP
rs908831890 315 dbSNP
rs979835225 323 dbSNP
rs1470756928 324 dbSNP
rs1479743580 324 dbSNP
rs1480188619 324 dbSNP
rs983049707 324 dbSNP
rs1198560581 325 dbSNP
rs1423036283 325 dbSNP
rs1217058164 326 dbSNP
rs1353710335 326 dbSNP
rs971107948 326 dbSNP
rs1355635384 327 dbSNP
rs1304654753 328 dbSNP
rs1365629622 329 dbSNP
rs376462698 330 dbSNP
rs1403856455 336 dbSNP
rs1280836717 337 dbSNP
rs1364650604 337 dbSNP
rs1277676746 338 dbSNP
rs955579979 340 dbSNP
rs772537194 344 dbSNP
rs988456659 345 dbSNP
rs1341099492 350 dbSNP
rs997223586 355 dbSNP
rs11811745 357 dbSNP
rs964142947 368 dbSNP
rs955907638 369 dbSNP
rs1292827969 374 dbSNP
rs1490200643 375 dbSNP
rs1220281087 379 dbSNP
rs35753959 383 dbSNP
rs1033055912 384 dbSNP
rs748414064 390 dbSNP
rs903011888 394 dbSNP
rs1041697609 395 dbSNP
rs779505992 411 dbSNP
rs190693169 412 dbSNP
rs1055479798 415 dbSNP
rs936961547 417 dbSNP
rs753982825 425 dbSNP
rs185051622 429 dbSNP
rs890515121 436 dbSNP
rs1320940093 437 dbSNP
rs941569302 438 dbSNP
rs1432095956 445 dbSNP
rs1288862721 447 dbSNP
rs1360273280 450 dbSNP
rs548753007 452 dbSNP
rs1316198351 454 dbSNP
rs983466715 455 dbSNP
rs934272748 465 dbSNP
rs929288868 467 dbSNP
rs1317652380 468 dbSNP
rs1473433039 472 dbSNP
rs1368477233 473 dbSNP
rs1188999075 477 dbSNP
rs1463507611 477 dbSNP
rs527271706 482 dbSNP
rs1243537793 491 dbSNP
rs975442460 496 dbSNP
rs1161158272 502 dbSNP
rs1409521106 503 dbSNP
rs560026971 507 dbSNP
rs1400819754 508 dbSNP
rs1158987198 510 dbSNP
rs1256325608 513 dbSNP
rs1455084079 515 dbSNP
rs938291629 515 dbSNP
rs964006041 516 dbSNP
rs544684228 523 dbSNP
rs577437165 524 dbSNP
rs978839915 526 dbSNP
rs1351467895 536 dbSNP
rs1223246778 538 dbSNP
rs967230447 542 dbSNP
rs1020104587 555 dbSNP
rs982253323 558 dbSNP
rs1460760063 561 dbSNP
rs192265035 562 dbSNP
rs1356982859 565 dbSNP
rs1176081309 568 dbSNP
rs544110999 570 dbSNP
rs1267210722 579 dbSNP
rs1231525928 587 dbSNP
rs573807658 590 dbSNP
rs1409136484 603 dbSNP
rs916969567 604 dbSNP
rs555630345 618 dbSNP
rs756260748 621 dbSNP
rs533978052 637 dbSNP
rs560427353 659 dbSNP
rs1331319529 670 dbSNP
rs1336538118 677 dbSNP
rs1001188172 678 dbSNP
rs1286473968 685 dbSNP
rs1347533271 686 dbSNP
rs1325011994 697 dbSNP
rs1318084677 702 dbSNP
rs1365508471 702 dbSNP
rs78360744 704 dbSNP
rs776158671 710 dbSNP
rs1406372123 717 dbSNP
rs573174815 719 dbSNP
rs1163450187 721 dbSNP
rs1459391550 724 dbSNP
rs1322531223 726 dbSNP
rs1416553020 727 dbSNP
rs1193883420 728 dbSNP
rs1037434760 729 dbSNP
rs558311402 733 dbSNP
rs964567739 737 dbSNP
rs886159205 739 dbSNP
rs1017490746 740 dbSNP
rs140983887 740 dbSNP
rs796470955 740 dbSNP
rs1200758715 751 dbSNP
rs1429144662 759 dbSNP
rs1047244884 768 dbSNP
rs934113192 786 dbSNP
rs79617453 787 dbSNP
rs976062917 788 dbSNP
rs759170042 789 dbSNP
rs925927722 794 dbSNP
rs1282750226 799 dbSNP
rs1192184752 804 dbSNP
rs1230978048 807 dbSNP
rs1271657108 811 dbSNP
rs938012959 814 dbSNP
rs1227203567 815 dbSNP
rs1272087161 818 dbSNP
rs905406543 831 dbSNP
rs765907268 838 dbSNP
rs1267563541 839 dbSNP
rs1046691851 851 dbSNP
rs1452036849 853 dbSNP
rs949525408 855 dbSNP
rs914113830 863 dbSNP
rs1475316623 864 dbSNP
rs1052857346 865 dbSNP
rs978871240 873 dbSNP
rs967470791 874 dbSNP
rs1302548396 877 dbSNP
rs925736370 886 dbSNP
rs1020766547 888 dbSNP
rs1384991735 889 dbSNP
rs1478648870 890 dbSNP
rs1320284398 892 dbSNP
rs1326771874 895 dbSNP
rs978808306 903 dbSNP
rs1295170981 906 dbSNP
rs992680459 909 dbSNP
rs960133043 919 dbSNP
rs1246275404 923 dbSNP
rs964347980 924 dbSNP
rs1034308333 930 dbSNP
rs1220629165 931 dbSNP
rs1001387309 933 dbSNP
rs1269895590 936 dbSNP
rs1128817 937 dbSNP
rs1445399464 938 dbSNP
rs1333237534 948 dbSNP
rs1324406279 953 dbSNP
rs1015894315 957 dbSNP
rs1440861140 964 dbSNP
rs767583788 986 dbSNP
rs1393011084 988 dbSNP
rs1455447627 990 dbSNP
rs886192201 999 dbSNP
rs954542131 1000 dbSNP
rs1385532169 1002 dbSNP
rs1051916820 1004 dbSNP
rs1026589625 1017 dbSNP
rs1384797765 1021 dbSNP
rs1452914867 1033 dbSNP
rs1311623633 1034 dbSNP
rs934210361 1046 dbSNP
rs1416943625 1047 dbSNP
rs901336007 1053 dbSNP
rs1260832137 1062 dbSNP
rs1039979843 1063 dbSNP
rs942919249 1065 dbSNP
rs926165861 1071 dbSNP
rs1478221867 1073 dbSNP
rs1043100544 1076 dbSNP
rs945993776 1077 dbSNP
rs1181464266 1083 dbSNP
rs1002172057 1086 dbSNP
rs1421142648 1086 dbSNP
rs1182534366 1090 dbSNP
rs1363315571 1092 dbSNP
rs905229814 1095 dbSNP
rs551152314 1098 dbSNP
rs913347808 1106 dbSNP
rs1407995732 1109 dbSNP
rs1238812153 1112 dbSNP
rs1200594572 1115 dbSNP
rs1302073385 1117 dbSNP
rs1436188945 1118 dbSNP
rs1392774566 1122 dbSNP
rs1307009923 1123 dbSNP
rs1272531298 1125 dbSNP
rs1019397983 1136 dbSNP
rs1220054592 1136 dbSNP
rs1328511087 1141 dbSNP
rs10666591 1142 dbSNP
rs187093892 1142 dbSNP
rs1347524559 1146 dbSNP
rs892625280 1151 dbSNP
rs1481708825 1153 dbSNP
rs1196660616 1155 dbSNP
rs1251166023 1155 dbSNP
rs1471676536 1155 dbSNP
rs34371654 1155 dbSNP
rs5780025 1155 dbSNP
rs1301707831 1156 dbSNP
rs1357224480 1158 dbSNP
rs959921708 1158 dbSNP
rs1463184505 1162 dbSNP
rs1298457964 1163 dbSNP
rs1369369159 1164 dbSNP
rs1407507211 1168 dbSNP
rs568702998 1172 dbSNP
rs1346624486 1179 dbSNP
rs547259920 1181 dbSNP
rs1219174679 1186 dbSNP
rs979875563 1187 dbSNP
rs1228394003 1188 dbSNP
rs1274258004 1196 dbSNP
rs1224769174 1199 dbSNP
rs1269698804 1200 dbSNP
rs963281956 1202 dbSNP
rs1334030220 1206 dbSNP
rs1443705090 1212 dbSNP
rs1190600748 1216 dbSNP
rs1352313954 1217 dbSNP
rs1422791417 1222 dbSNP
rs1430126448 1231 dbSNP
rs1053001867 1233 dbSNP
rs1016094414 1246 dbSNP
rs1327712522 1247 dbSNP
rs527319362 1248 dbSNP
rs773137348 1250 dbSNP
rs925653571 1251 dbSNP
rs1436385597 1255 dbSNP
rs1292333563 1258 dbSNP
rs1364501047 1260 dbSNP
rs1383083871 1261 dbSNP
rs1042794979 1263 dbSNP
rs943030414 1270 dbSNP
rs6668164 1271 dbSNP
rs1292568120 1283 dbSNP
rs1321262665 1292 dbSNP
rs142690378 1302 dbSNP
rs1244960173 1311 dbSNP
rs1030121044 1313 dbSNP
rs184307307 1315 dbSNP
rs1486818788 1318 dbSNP
rs997657109 1334 dbSNP
rs901371563 1338 dbSNP
rs1447271181 1345 dbSNP
rs771893847 1358 dbSNP
rs1413847902 1361 dbSNP
rs1404300533 1363 dbSNP
rs1162122111 1364 dbSNP
rs954655252 1367 dbSNP
rs919199111 1377 dbSNP
rs562709543 1386 dbSNP
rs972269555 1386 dbSNP
rs963251940 1390 dbSNP
rs1016754207 1398 dbSNP
rs1378502191 1412 dbSNP
rs1007042612 1418 dbSNP
rs1232380220 1420 dbSNP
rs1211040911 1435 dbSNP
rs1002330481 1440 dbSNP
rs1286466758 1440 dbSNP
rs969360874 1446 dbSNP
rs1267254758 1457 dbSNP
rs1278519568 1458 dbSNP
rs1463411108 1478 dbSNP
rs544609391 1485 dbSNP
rs1237648634 1486 dbSNP
rs532824244 1494 dbSNP
rs946106149 1499 dbSNP
rs148204949 1500 dbSNP
rs1312078193 1503 dbSNP
rs191801113 1506 dbSNP
rs913203585 1507 dbSNP
rs1159158078 1508 dbSNP
rs1386866164 1509 dbSNP
rs1471188506 1512 dbSNP
rs1335298677 1516 dbSNP
rs1358760775 1518 dbSNP
rs1446097140 1525 dbSNP
rs1281339923 1531 dbSNP
rs747950425 1532 dbSNP
rs143393661 1535 dbSNP
rs938776961 1548 dbSNP
rs1205289994 1564 dbSNP
rs575261245 1565 dbSNP
rs1312300411 1570 dbSNP
rs149220070 1573 dbSNP
rs1207653317 1583 dbSNP
rs1448233893 1586 dbSNP
rs904054024 1587 dbSNP
rs1483118491 1589 dbSNP
rs573731036 1594 dbSNP
rs979908274 1600 dbSNP
rs573176173 1601 dbSNP
rs1310773993 1605 dbSNP
rs558147727 1610 dbSNP
rs774307259 1632 dbSNP
rs187472952 1633 dbSNP
rs888769535 1635 dbSNP
rs575760392 1638 dbSNP
rs1051355257 1641 dbSNP
rs866640402 1642 dbSNP
rs1409233529 1665 dbSNP
rs879647780 1679 dbSNP
rs1348484389 1695 dbSNP
rs1235349321 1696 dbSNP
rs909168087 1697 dbSNP
rs1275209252 1706 dbSNP
rs1182497845 1712 dbSNP
rs919135461 1716 dbSNP
rs1217083974 1725 dbSNP
rs1274735467 1727 dbSNP
rs1255661870 1729 dbSNP
rs983329778 1730 dbSNP
rs1187573889 1735 dbSNP
rs1203759349 1739 dbSNP
rs1248990371 1748 dbSNP
rs1488787661 1754 dbSNP
rs941857819 1776 dbSNP
rs1246457809 1779 dbSNP
rs1477273794 1781 dbSNP
rs145308442 1783 dbSNP
rs909071784 1784 dbSNP
rs1030398728 1795 dbSNP
rs1166735847 1796 dbSNP
rs775400303 1798 dbSNP
rs1009062576 1804 dbSNP
rs1388438120 1805 dbSNP
rs772883377 1810 dbSNP
rs769332831 1813 dbSNP
rs11804058 1814 dbSNP
rs758948231 1824 dbSNP
rs1299583391 1831 dbSNP
rs1233364565 1834 dbSNP
rs568620603 1843 dbSNP
rs553414616 1855 dbSNP
rs535290065 1856 dbSNP
rs1413795820 1857 dbSNP
rs1043350358 1861 dbSNP
rs1450425665 1864 dbSNP
rs956740793 1864 dbSNP
rs1290436376 1866 dbSNP
rs1195701747 1870 dbSNP
rs1249052123 1873 dbSNP
rs1031664188 1876 dbSNP
rs1186986732 1878 dbSNP
rs1344503022 1883 dbSNP
rs1458515529 1901 dbSNP
rs1162758910 1907 dbSNP
rs1010890483 1908 dbSNP
rs776369238 1910 dbSNP
rs1165476254 1914 dbSNP
rs1322233366 1918 dbSNP
rs1463065404 1921 dbSNP
rs1057445984 1923 dbSNP
rs1018426574 1932 dbSNP
rs1007026566 1933 dbSNP
rs1341918399 1947 dbSNP
rs888825422 1948 dbSNP
rs1051467070 1949 dbSNP
rs932971749 1953 dbSNP
rs1354793739 1959 dbSNP
rs566141007 1960 dbSNP
rs878983681 1965 dbSNP
rs897527388 1979 dbSNP
rs182919435 1983 dbSNP
rs905964754 1992 dbSNP
rs1245142508 1993 dbSNP
rs532763865 1997 dbSNP
rs941984834 1998 dbSNP
rs1186843957 2000 dbSNP
rs770451873 2002 dbSNP
rs941908187 2003 dbSNP
rs909032723 2007 dbSNP
rs1161367347 2013 dbSNP
rs1456462928 2016 dbSNP
rs775758341 2016 dbSNP
rs980579919 2024 dbSNP
rs568650903 2025 dbSNP
rs780554081 2045 dbSNP
rs748550321 2049 dbSNP
rs1336214953 2053 dbSNP
rs1270763719 2065 dbSNP
rs917974550 2067 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000294740.3 | 3UTR | AACAGAUUGAUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
33 hsa-miR-2909 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254788 XRCC6 X-ray repair cross complementing 6 2 4
MIRT464426 UHMK1 U2AF homology motif kinase 1 2 2
MIRT478185 DDX6 DEAD-box helicase 6 2 6
MIRT481768 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT489915 RTKN rhotekin 2 2
MIRT500566 VPS4A vacuolar protein sorting 4 homolog A 2 8
MIRT510700 SREK1IP1 SREK1 interacting protein 1 2 6
MIRT513331 CDK2 cyclin dependent kinase 2 2 4
MIRT524310 CTC1 CST telomere replication complex component 1 2 4
MIRT533571 TOMM40L translocase of outer mitochondrial membrane 40 like 2 2
MIRT537784 EIF4E3 eukaryotic translation initiation factor 4E family member 3 2 2
MIRT540489 ZMAT4 zinc finger matrin-type 4 2 8
MIRT547020 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT549561 C19orf12 chromosome 19 open reading frame 12 2 2
MIRT557346 HBP1 HMG-box transcription factor 1 2 4
MIRT564692 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT570167 LIPG lipase G, endothelial type 2 2
MIRT621677 UBE2QL1 ubiquitin conjugating enzyme E2 Q family like 1 2 2
MIRT629121 APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 2 4
MIRT633745 MCM9 minichromosome maintenance 9 homologous recombination repair factor 2 2
MIRT634178 TXNDC16 thioredoxin domain containing 16 2 2
MIRT646387 SLC22A6 solute carrier family 22 member 6 2 2
MIRT651181 ZNF281 zinc finger protein 281 2 2
MIRT651892 UFD1L ubiquitin recognition factor in ER associated degradation 1 2 2
MIRT675180 KIF1C kinesin family member 1C 2 2
MIRT682670 CPM carboxypeptidase M 2 2
MIRT685990 NEK4 NIMA related kinase 4 2 2
MIRT698850 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT699396 SLC2A1 solute carrier family 2 member 1 2 2
MIRT723260 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 2
MIRT725320 NFASC neurofascin 2 2
MIRT734596 CD276 CD276 molecule 2 0
MIRT734938 PTEN phosphatase and tensin homolog 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-2909 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2909 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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