pre-miRNA Information
pre-miRNA hsa-mir-6509   
Genomic Coordinates chr7: 135206994 - 135207078
Description Homo sapiens miR-6509 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6509-3p
Sequence 52| UUCCACUGCCACUACCUAAUUU |73
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778601614 1 dbSNP
rs754554776 3 dbSNP
rs767798995 3 dbSNP
rs145322812 4 dbSNP
rs773941257 5 dbSNP
rs768273593 9 dbSNP
rs984565062 12 dbSNP
rs748872915 13 dbSNP
rs774861125 14 dbSNP
rs13241975 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZCCHC2   
Synonyms C18orf49
Description zinc finger CCHC-type containing 2
Transcript NM_017742   
Expression
Putative miRNA Targets on ZCCHC2
3'UTR of ZCCHC2
(miRNA target sites are highlighted)
>ZCCHC2|NM_017742|3'UTR
   1 AACGAGTAAAGCTTGCCTACTTAATACACTCAAGTGTGGGGAGTCATGGGGTGTGGAGGGGAGGAAAGGAAAGGTATTTT
  81 GTTTCTTTGTCTATACATTTCCTAGATTTCTATGCAGTTGGGATTTTTCATTTCTCTTGTACCAATGTCCAAAACAAGAA
 161 AGAATGCAATGCTTTTGAGCCTCTGGTCTCCTGGTTCAACAACAGGCTTATATGTATGATACATGTAATTTAAACCTTCA
 241 GACAAACTTAAATGTTGGTGCGTGCTTTTTTTTTTTTTTTTACACTGAATACTTGCTGTGTGCAATGTTTACTGAATCTT
 321 TAAAACTGTGTATTTGACCTTTTTTTTACAACACTGGTGACAGTCATATGGTTTTGAAAAAAAAAAGAAATTTTGCTTCT
 401 TCCCAGCTTTTCTCACTTTCACCCTAAACGACACTTCCTCCCCAGCCAGCCTCACTCTGTCTCCGGCCCGCAGCAGGAGC
 481 AGCCAGCAGTGCATTCACCCCACTTTTGTAAACTGCTCTGCATATAAACCAAGGGCAGAATGTTTCACCCTGATCTTATG
 561 GGAGGAATCAAACTCCCAAAATAGTGTGTATATATGTAATAAACAGCGTCACGTAAATACATATATGCAGTGCTTGTTGT
 641 CCAAATAGAAATGAAAATAAGTGGAAGAGAGAGGAAGAAGTCAAACCATATGAAACTGAAAAAATATGACGTACGAAATG
 721 GACAAAAAGCTTTTTCTGAAACCAACTTTTTACTTCCATCATCCTTTTTTAGCCTGTTGCTTCAGAGAGACACAAAGTGA
 801 ACACACTGGTGTGAATGTCGCTCTCTGTGTGCTTGTGTTTGTAATGAAAGTCTACAGCCAATTTTACTTGTCTACCACCG
 881 TGTTGTGCTCAAAGAGACACTACTTGAGTGAAGATTTCTTCTTTCCCTGTACCAGCTGTTACAGTGTTACGTTGTGTTTA
 961 AAATGTGTATGGTTTATTGCAATCTGAACAGAGCTATGGGTTTCTACCATAAGTCAGGTTGTTTGTTCCCTAACCTGTCT
1041 CTCATAGCAAAGTCACTTTTATAACAGTTTACCACTATGCTTGATTATAATGTGAAAGGCGGAATTCTGAGTGTGTTAAG
1121 ATGGTATTAATCATGTCGGTGTCATGTCACTAAGTTTAATGCTGCTGTTTTTAAAAAAAAAAAAAAGTTTTTTTAAAAAG
1201 CCAATCTATGTACTAAATTGCTTCCAGGTAATTTTTGATTTCCTAAAGTGCACTGAGGTTATCTGGAAGATTGGGTGTAT
1281 TTTTTGGTGACTGCTGCATTCATCAGCAATGAACAGTTTCCACTGTATAGTCCTAGGGGTCAGGGGGTGGGGGTTTCATT
1361 TTCCATTCCTCAGCACAGAGCAGAAATGATAGATTTTTATTGTTTGGAGTAACGTTGGTATGCAGCAGAGGAACGTAAAC
1441 ATTTGGTCTTGGTTCAGAAGCCTAACAGATTGCTAGACAAGAGAAAAAACTTGAAGAAAAAAGAAGCTTAATTTCATGCT
1521 TCATAAGTAGCATTTATATTTATAGCACCAATGTACATTTTGAAACTTTCTTTCAGGGGTGGGAGTTATGGGGAAGGGGT
1601 GGGTGTGAAGGGGTAGATGAAAGCTTTAATTTAGAAAGAAAGTTCAAGTAAAGGAAATTATTTTGATTAAATATATTTTA
1681 TTTGATCTGGGTATTTTTGGACCACATTATTAAATTAATTGTTAAGCTGCAGTTGAGTTGTTCAAGTGAGAGTTTTGATA
1761 AGCCACTTATGGGCCGCGTTGTGAATCACTTGCCAGTTGTACTTTATGGAGCTTATTTTATGATTTAAAATACTGTACTG
1841 TACATAGGAGGTATGTTACCTTCTCCTTATTTGTATGTTTACCATATACTTTGATATTTGAAATGTTATGTACTGGAAAG
1921 GCCACTTATATTTCTAGAACAGATTGGATTTTATGCAACCTTTTTTCCTTGAATTAACAGCAATAAAAAAATGAAAAACA
2001 GCTTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuUAAUCCAUCAC--CGUCACCUu 5'
            :|| |||| ||  |||| ||| 
Target 5' acGTT-GGTA-TGCAGCAGAGGAa 3'
1412 - 1433 128.00 -12.40
2
miRNA  3' uuUAAUCCAUCACCGUCACCUu 5'
            |||:   ||  ||||| || 
Target 5' taATTGTTAAGCTGCAGTTGAg 3'
1716 - 1737 124.00 -9.10
3
miRNA  3' uuuaauccaucaccgUCACCUu 5'
                         |||||| 
Target 5' atagaaatgaaaataAGTGGAa 3'
645 - 666 120.00 -8.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM2881556 3 COSMIC
COSN30163982 4 COSMIC
COSN30466191 21 COSMIC
COSN30530885 38 COSMIC
COSN31498973 39 COSMIC
COSN30187007 52 COSMIC
COSN9340292 64 COSMIC
COSN31786324 65 COSMIC
COSN30167644 69 COSMIC
COSN31583212 135 COSMIC
COSN31526106 143 COSMIC
COSN20115111 282 COSMIC
COSN31557634 454 COSMIC
COSN31590257 490 COSMIC
COSN26570963 563 COSMIC
COSN5430622 777 COSMIC
COSN6130262 813 COSMIC
COSN25725978 1000 COSMIC
COSN28706772 1044 COSMIC
COSN30165544 1142 COSMIC
COSN26567545 1175 COSMIC
COSN26571323 1176 COSMIC
COSN20115119 1186 COSMIC
COSN20115115 1187 COSMIC
COSN20115116 1187 COSMIC
COSN14813838 1188 COSMIC
COSN14820128 1189 COSMIC
COSN31534751 1225 COSMIC
COSN1208145 1307 COSMIC
COSN31607148 1358 COSMIC
COSN31481808 1414 COSMIC
COSN28650182 1436 COSMIC
COSN6130263 1727 COSMIC
COSN31481379 1778 COSMIC
COSN25917832 1885 COSMIC
COSN31583342 1888 COSMIC
COSN26640601 1982 COSMIC
rs11557713 65 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs750213191 4 dbSNP
rs760718338 5 dbSNP
rs1366260873 6 dbSNP
rs1244637207 7 dbSNP
rs369947304 22 dbSNP
rs1032134185 23 dbSNP
rs777076620 28 dbSNP
rs760078050 29 dbSNP
rs373565255 32 dbSNP
rs758784087 33 dbSNP
rs879093900 35 dbSNP
rs1423151650 36 dbSNP
rs1310597693 37 dbSNP
rs750643689 38 dbSNP
rs1337614943 40 dbSNP
rs1408505268 46 dbSNP
rs763886075 47 dbSNP
rs1173898710 48 dbSNP
rs1451373994 62 dbSNP
rs11557713 65 dbSNP
rs1480083332 73 dbSNP
rs1255287767 74 dbSNP
rs1175752766 81 dbSNP
rs1430043185 94 dbSNP
rs542255816 106 dbSNP
rs916115446 113 dbSNP
rs1157934973 119 dbSNP
rs948888160 121 dbSNP
rs1267940360 131 dbSNP
rs1416294064 135 dbSNP
rs1352890005 139 dbSNP
rs954503829 148 dbSNP
rs144366059 166 dbSNP
rs1340485165 167 dbSNP
rs1335604187 170 dbSNP
rs910245830 172 dbSNP
rs927722493 175 dbSNP
rs78317986 176 dbSNP
rs1046688996 180 dbSNP
rs765887921 186 dbSNP
rs1300452556 195 dbSNP
rs372308391 200 dbSNP
rs1415592531 212 dbSNP
rs547114095 213 dbSNP
rs1038290304 217 dbSNP
rs1473080510 223 dbSNP
rs899689894 224 dbSNP
rs75819440 227 dbSNP
rs1284537882 241 dbSNP
rs1030171342 242 dbSNP
rs1445545128 243 dbSNP
rs1247593708 245 dbSNP
rs1209784303 246 dbSNP
rs955459149 247 dbSNP
rs1271839061 248 dbSNP
rs1228311475 250 dbSNP
rs930101412 254 dbSNP
rs1047246530 257 dbSNP
rs1428008917 259 dbSNP
rs1364034459 261 dbSNP
rs1283036145 262 dbSNP
rs1165095703 266 dbSNP
rs1437029853 266 dbSNP
rs1474445697 266 dbSNP
rs1491193093 266 dbSNP
rs34072948 266 dbSNP
rs35651410 266 dbSNP
rs568874001 266 dbSNP
rs796434745 266 dbSNP
rs878965572 266 dbSNP
rs1317157825 269 dbSNP
rs1389790695 272 dbSNP
rs79319245 280 dbSNP
rs80056495 281 dbSNP
rs1189388168 282 dbSNP
rs1466413024 282 dbSNP
rs1218458620 283 dbSNP
rs538996616 284 dbSNP
rs1490136979 285 dbSNP
rs1200036224 288 dbSNP
rs1221253725 300 dbSNP
rs1271040893 306 dbSNP
rs1452738947 313 dbSNP
rs1479048249 314 dbSNP
rs1292585295 320 dbSNP
rs558090540 322 dbSNP
rs1212321642 331 dbSNP
rs1156906189 333 dbSNP
rs137906803 340 dbSNP
rs1407462270 340 dbSNP
rs1297680997 341 dbSNP
rs1401532738 345 dbSNP
rs1368300904 355 dbSNP
rs571413654 362 dbSNP
rs1436872599 367 dbSNP
rs949527796 368 dbSNP
rs553073826 370 dbSNP
rs1424490188 372 dbSNP
rs1370090936 377 dbSNP
rs1451603461 377 dbSNP
rs796604053 377 dbSNP
rs751227016 378 dbSNP
rs1191001213 382 dbSNP
rs905242122 383 dbSNP
rs557560087 390 dbSNP
rs1000825537 398 dbSNP
rs1203110192 417 dbSNP
rs1439324487 425 dbSNP
rs537334653 429 dbSNP
rs892395467 430 dbSNP
rs1009331350 431 dbSNP
rs754407646 433 dbSNP
rs999266786 441 dbSNP
rs780778858 443 dbSNP
rs1030188019 446 dbSNP
rs747710837 449 dbSNP
rs556902752 451 dbSNP
rs1277541611 460 dbSNP
rs573774396 461 dbSNP
rs921617202 464 dbSNP
rs542352987 465 dbSNP
rs990403256 466 dbSNP
rs1431646824 470 dbSNP
rs371723957 471 dbSNP
rs1291860811 476 dbSNP
rs962998054 478 dbSNP
rs1436027923 480 dbSNP
rs1175820841 497 dbSNP
rs552609927 500 dbSNP
rs973071245 502 dbSNP
rs1253104248 503 dbSNP
rs920153222 510 dbSNP
rs1484367324 511 dbSNP
rs970659823 517 dbSNP
rs779634313 519 dbSNP
rs375978339 523 dbSNP
rs544575965 526 dbSNP
rs1227530374 536 dbSNP
rs949498334 550 dbSNP
rs1290090258 556 dbSNP
rs1411744245 560 dbSNP
rs1376989227 563 dbSNP
rs746225647 570 dbSNP
rs1449086956 572 dbSNP
rs34455131 575 dbSNP
rs1361093836 579 dbSNP
rs1157435939 584 dbSNP
rs1457009849 587 dbSNP
rs1383686975 607 dbSNP
rs1444320239 608 dbSNP
rs939080758 609 dbSNP
rs1047243948 613 dbSNP
rs1254954647 614 dbSNP
rs1181903340 622 dbSNP
rs1311288170 634 dbSNP
rs772502185 637 dbSNP
rs1053732084 639 dbSNP
rs879632966 647 dbSNP
rs908246539 653 dbSNP
rs1231451531 654 dbSNP
rs775511539 659 dbSNP
rs1448430067 662 dbSNP
rs1312462565 665 dbSNP
rs1312164704 666 dbSNP
rs1381596944 666 dbSNP
rs1038322471 671 dbSNP
rs1381659286 671 dbSNP
rs747275001 674 dbSNP
rs768806771 686 dbSNP
rs932493708 691 dbSNP
rs1050911571 692 dbSNP
rs1007806004 706 dbSNP
rs565253765 707 dbSNP
rs1273698584 711 dbSNP
rs891214491 712 dbSNP
rs531144907 715 dbSNP
rs1465056320 716 dbSNP
rs998984772 717 dbSNP
rs1200607544 722 dbSNP
rs1031716023 726 dbSNP
rs1241456558 729 dbSNP
rs1265922921 733 dbSNP
rs1222407675 743 dbSNP
rs893162965 744 dbSNP
rs1444261894 746 dbSNP
rs963143778 751 dbSNP
rs1188632989 757 dbSNP
rs182506646 757 dbSNP
rs376752295 758 dbSNP
rs1011521078 759 dbSNP
rs1366161096 762 dbSNP
rs561372059 762 dbSNP
rs994488729 765 dbSNP
rs572827589 777 dbSNP
rs1026017305 781 dbSNP
rs1294559038 796 dbSNP
rs1474660580 801 dbSNP
rs1167833074 807 dbSNP
rs1368227482 808 dbSNP
rs770790586 810 dbSNP
rs776656673 811 dbSNP
rs1449753181 813 dbSNP
rs1391583491 816 dbSNP
rs761943584 820 dbSNP
rs530308885 821 dbSNP
rs1267990884 824 dbSNP
rs1334142634 826 dbSNP
rs951603607 826 dbSNP
rs982025005 837 dbSNP
rs1204495776 838 dbSNP
rs1404846439 844 dbSNP
rs1035896134 862 dbSNP
rs950945133 875 dbSNP
rs141409647 876 dbSNP
rs908277650 880 dbSNP
rs941016804 881 dbSNP
rs1302394944 883 dbSNP
rs1226508082 886 dbSNP
rs1392307889 888 dbSNP
rs973708755 890 dbSNP
rs981361937 893 dbSNP
rs1319929505 895 dbSNP
rs773147403 897 dbSNP
rs1372032441 898 dbSNP
rs1170386129 904 dbSNP
rs1261374685 913 dbSNP
rs926685031 915 dbSNP
rs1200698783 918 dbSNP
rs1201227798 919 dbSNP
rs1250922163 927 dbSNP
rs1258604379 928 dbSNP
rs1483384738 930 dbSNP
rs369928845 937 dbSNP
rs550085952 937 dbSNP
rs1199003511 940 dbSNP
rs566927748 945 dbSNP
rs3833190 949 dbSNP
rs397840822 949 dbSNP
rs1257007528 951 dbSNP
rs1264461006 952 dbSNP
rs921180883 953 dbSNP
rs1327744785 955 dbSNP
rs564356278 967 dbSNP
rs1288204590 976 dbSNP
rs1409917507 983 dbSNP
rs533309298 989 dbSNP
rs932553873 993 dbSNP
rs1479103792 994 dbSNP
rs866031838 996 dbSNP
rs145285230 997 dbSNP
rs890375428 1007 dbSNP
rs1411151866 1009 dbSNP
rs569210452 1010 dbSNP
rs891002287 1016 dbSNP
rs150940655 1018 dbSNP
rs934472451 1021 dbSNP
rs557211101 1023 dbSNP
rs1173962794 1029 dbSNP
rs1382329418 1033 dbSNP
rs762585943 1042 dbSNP
rs77119162 1044 dbSNP
rs8088581 1045 dbSNP
rs1022887598 1049 dbSNP
rs1342252284 1056 dbSNP
rs905850756 1057 dbSNP
rs1243369563 1063 dbSNP
rs1025985166 1064 dbSNP
rs1402993860 1068 dbSNP
rs1432644844 1071 dbSNP
rs1387705456 1074 dbSNP
rs759205751 1075 dbSNP
rs1282618886 1076 dbSNP
rs1458790093 1080 dbSNP
rs188108806 1088 dbSNP
rs1322904138 1092 dbSNP
rs767319103 1093 dbSNP
rs529326948 1096 dbSNP
rs1369284351 1101 dbSNP
rs549091720 1102 dbSNP
rs1025197171 1108 dbSNP
rs1247843946 1114 dbSNP
rs971405860 1119 dbSNP
rs1348832682 1127 dbSNP
rs980944099 1135 dbSNP
rs1204872599 1138 dbSNP
rs983588888 1139 dbSNP
rs1015368616 1140 dbSNP
rs140698309 1158 dbSNP
rs1363969885 1159 dbSNP
rs989561606 1160 dbSNP
rs766850776 1161 dbSNP
rs1268882583 1166 dbSNP
rs1322748716 1168 dbSNP
rs1433192536 1168 dbSNP
rs913987898 1168 dbSNP
rs1200388276 1172 dbSNP
rs1491462581 1172 dbSNP
rs11320033 1173 dbSNP
rs1198843211 1173 dbSNP
rs1293367840 1173 dbSNP
rs1452687488 1173 dbSNP
rs1491094279 1173 dbSNP
rs200828686 1173 dbSNP
rs371519156 1173 dbSNP
rs558135414 1173 dbSNP
rs558955871 1173 dbSNP
rs571720209 1173 dbSNP
rs71338281 1173 dbSNP
rs77361509 1173 dbSNP
rs869273686 1173 dbSNP
rs973744704 1173 dbSNP
rs201345990 1174 dbSNP
rs199852036 1175 dbSNP
rs945361815 1176 dbSNP
rs1216124335 1186 dbSNP
rs200046565 1186 dbSNP
rs1491544568 1187 dbSNP
rs377481611 1187 dbSNP
rs767632242 1187 dbSNP
rs370032876 1188 dbSNP
rs1052210611 1189 dbSNP
rs1437162205 1191 dbSNP
rs373009274 1195 dbSNP
rs558298078 1196 dbSNP
rs1347302144 1201 dbSNP
rs911797086 1205 dbSNP
rs1422579606 1209 dbSNP
rs575175435 1217 dbSNP
rs943311153 1222 dbSNP
rs1411849773 1223 dbSNP
rs1346077533 1226 dbSNP
rs1038881575 1232 dbSNP
rs1387369284 1244 dbSNP
rs932308470 1256 dbSNP
rs1334170092 1262 dbSNP
rs544623340 1270 dbSNP
rs1482410331 1272 dbSNP
rs1251895210 1273 dbSNP
rs755746288 1274 dbSNP
rs1310048097 1275 dbSNP
rs779507502 1276 dbSNP
rs192913617 1277 dbSNP
rs1325626956 1280 dbSNP
rs566195010 1280 dbSNP
rs765543816 1282 dbSNP
rs1013898846 1285 dbSNP
rs1298811173 1286 dbSNP
rs1444685939 1326 dbSNP
rs1024414384 1328 dbSNP
rs914662525 1330 dbSNP
rs1333945252 1331 dbSNP
rs906770401 1339 dbSNP
rs1157664070 1342 dbSNP
rs1489105937 1342 dbSNP
rs947507920 1344 dbSNP
rs1178413866 1345 dbSNP
rs1482085418 1346 dbSNP
rs150127022 1349 dbSNP
rs1210562176 1350 dbSNP
rs905885681 1353 dbSNP
rs2849623 1357 dbSNP
rs989612522 1366 dbSNP
rs1003272123 1375 dbSNP
rs1021007719 1394 dbSNP
rs185173939 1394 dbSNP
rs1381856255 1399 dbSNP
rs1057386945 1401 dbSNP
rs886665697 1403 dbSNP
rs987479264 1405 dbSNP
rs540791943 1414 dbSNP
rs1005054853 1415 dbSNP
rs1016405143 1416 dbSNP
rs963533354 1421 dbSNP
rs1196052063 1428 dbSNP
rs1350352558 1430 dbSNP
rs750973334 1435 dbSNP
rs3744927 1436 dbSNP
rs1457226680 1445 dbSNP
rs1346261026 1447 dbSNP
rs953767858 1454 dbSNP
rs1160701024 1461 dbSNP
rs551867648 1463 dbSNP
rs1421477825 1470 dbSNP
rs1412634914 1474 dbSNP
rs974620902 1479 dbSNP
rs1446216078 1480 dbSNP
rs920519910 1482 dbSNP
rs1207853935 1485 dbSNP
rs780441697 1487 dbSNP
rs1465308294 1490 dbSNP
rs1262376747 1492 dbSNP
rs1379408609 1494 dbSNP
rs1244176499 1496 dbSNP
rs1314829801 1497 dbSNP
rs1320060202 1509 dbSNP
rs571477134 1516 dbSNP
rs1047615446 1517 dbSNP
rs955918564 1519 dbSNP
rs886172583 1521 dbSNP
rs532690736 1522 dbSNP
rs1224399535 1524 dbSNP
rs988681361 1531 dbSNP
rs914445552 1533 dbSNP
rs1291082816 1542 dbSNP
rs1045393518 1544 dbSNP
rs1198734633 1552 dbSNP
rs947203418 1553 dbSNP
rs1163629775 1558 dbSNP
rs905564975 1566 dbSNP
rs369839559 1567 dbSNP
rs1044514403 1579 dbSNP
rs1459722692 1580 dbSNP
rs1428825232 1582 dbSNP
rs1001157098 1587 dbSNP
rs1182712434 1588 dbSNP
rs1488099489 1590 dbSNP
rs927339258 1590 dbSNP
rs537197662 1596 dbSNP
rs938712817 1615 dbSNP
rs1361908793 1616 dbSNP
rs894073194 1617 dbSNP
rs1228147759 1619 dbSNP
rs552697027 1625 dbSNP
rs1298177084 1627 dbSNP
rs768914684 1632 dbSNP
rs1385628392 1633 dbSNP
rs34535904 1635 dbSNP
rs1168223024 1642 dbSNP
rs1303253930 1644 dbSNP
rs1021571278 1645 dbSNP
rs966813476 1661 dbSNP
rs886696531 1671 dbSNP
rs1462176997 1672 dbSNP
rs1005174408 1681 dbSNP
rs1019034847 1688 dbSNP
rs1432548428 1699 dbSNP
rs1269469089 1701 dbSNP
rs1200240611 1702 dbSNP
rs964674196 1707 dbSNP
rs974754960 1710 dbSNP
rs1402675838 1719 dbSNP
rs1037957523 1722 dbSNP
rs1340275666 1731 dbSNP
rs1253496324 1742 dbSNP
rs1312154406 1745 dbSNP
rs1302508643 1751 dbSNP
rs1380274320 1764 dbSNP
rs562789966 1765 dbSNP
rs1348159719 1766 dbSNP
rs755217079 1770 dbSNP
rs1395689393 1771 dbSNP
rs996333996 1773 dbSNP
rs1028086694 1776 dbSNP
rs531685439 1777 dbSNP
rs112771180 1779 dbSNP
rs1465305500 1790 dbSNP
rs781451153 1797 dbSNP
rs1307479366 1800 dbSNP
rs953906022 1806 dbSNP
rs1218682133 1809 dbSNP
rs1007896685 1810 dbSNP
rs1259472138 1813 dbSNP
rs951967815 1816 dbSNP
rs550610777 1821 dbSNP
rs145764263 1835 dbSNP
rs1199097927 1840 dbSNP
rs955703601 1852 dbSNP
rs949827502 1856 dbSNP
rs1237704514 1862 dbSNP
rs988712521 1866 dbSNP
rs1484111490 1868 dbSNP
rs1045852402 1872 dbSNP
rs536063202 1876 dbSNP
rs1184624548 1878 dbSNP
rs546416941 1882 dbSNP
rs535651913 1884 dbSNP
rs927069383 1887 dbSNP
rs1260934563 1906 dbSNP
rs748168341 1910 dbSNP
rs1337173146 1916 dbSNP
rs566313399 1917 dbSNP
rs914476485 1921 dbSNP
rs538385974 1922 dbSNP
rs28373970 1926 dbSNP
rs1406625515 1930 dbSNP
rs1338417635 1941 dbSNP
rs879413374 1945 dbSNP
rs980317740 1947 dbSNP
rs1468311197 1969 dbSNP
rs927401853 1979 dbSNP
rs1387749884 1985 dbSNP
rs1158100623 1990 dbSNP
rs1470515079 1994 dbSNP
rs1365772048 1997 dbSNP
rs35260291 1999 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuuaauccaucaccgUCACCUu 5'
                         |||||| 
Target 5' ---------aaaauaAGUGGAa 3'
1 - 13
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000269499.5 | 3UTR | AAAAUAAGUGGAAGAGAGAGGAAGAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6509-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055374 PDCD4 programmed cell death 4 2 4
MIRT378341 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT444668 CDKL2 cyclin dependent kinase like 2 2 2
MIRT446953 CD248 CD248 molecule 2 2
MIRT460332 CAMK4 calcium/calmodulin dependent protein kinase IV 2 6
MIRT464078 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT464586 UBN2 ubinuclein 2 2 2
MIRT468482 SESN3 sestrin 3 2 2
MIRT468962 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT475455 HSPA8 heat shock protein family A (Hsp70) member 8 2 2
MIRT482403 ADRB1 adrenoceptor beta 1 2 10
MIRT486992 ZFAND2B zinc finger AN1-type containing 2B 2 2
MIRT489397 TUBB2A tubulin beta 2A class IIa 2 2
MIRT526319 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526560 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT526732 ZNF138 zinc finger protein 138 2 8
MIRT531581 STXBP5L syntaxin binding protein 5 like 2 2
MIRT532011 NOX5 NADPH oxidase 5 2 2
MIRT533407 TXLNG taxilin gamma 2 2
MIRT533436 TRPC5 transient receptor potential cation channel subfamily C member 5 2 2
MIRT533866 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT539254 ANKRD50 ankyrin repeat domain 50 2 2
MIRT541451 C15orf48 chromosome 15 open reading frame 48 2 2
MIRT566794 MIER3 MIER family member 3 2 2
MIRT569294 SURF6 surfeit 6 2 2
MIRT571336 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT572802 PPP3CB protein phosphatase 3 catalytic subunit beta 2 2
MIRT572813 MYO1C myosin IC 2 2
MIRT574219 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT607259 GRAMD1B GRAM domain containing 1B 2 4
MIRT609307 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT615459 REPS1 RALBP1 associated Eps domain containing 1 2 2
MIRT616861 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT619415 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT619652 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT625325 TNFRSF13B TNF receptor superfamily member 13B 2 2
MIRT638980 ARFIP2 ADP ribosylation factor interacting protein 2 2 2
MIRT639458 ZNF429 zinc finger protein 429 2 2
MIRT640550 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT641473 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT642720 ATXN3 ataxin 3 2 2
MIRT643048 SMN1 survival of motor neuron 1, telomeric 2 2
MIRT644921 SMN2 survival of motor neuron 2, centromeric 2 2
MIRT645875 ZNF275 zinc finger protein 275 2 2
MIRT649824 LIPG lipase G, endothelial type 2 2
MIRT649851 GYS2 glycogen synthase 2 2 2
MIRT649972 TRAFD1 TRAF-type zinc finger domain containing 1 2 2
MIRT650675 ZNF259 ZPR1 zinc finger 1 1
MIRT651319 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT652876 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT652881 SYVN1 synoviolin 1 2 2
MIRT654144 RPAP2 RNA polymerase II associated protein 2 2 2
MIRT657080 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657181 INO80C INO80 complex subunit C 2 2
MIRT657830 GJD3 gap junction protein delta 3 2 2
MIRT657897 GDF7 growth differentiation factor 7 2 2
MIRT659631 CDKN2AIP CDKN2A interacting protein 2 2
MIRT663115 SPTA1 spectrin alpha, erythrocytic 1 2 2
MIRT664739 METTL16 methyltransferase like 16 2 2
MIRT667551 LRAT lecithin retinol acyltransferase 2 2
MIRT668552 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT682893 XIAP X-linked inhibitor of apoptosis 2 2
MIRT683092 PRRG4 proline rich and Gla domain 4 2 2
MIRT683102 TIMM10B translocase of inner mitochondrial membrane 10B 2 2
MIRT697648 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT709158 ZNF419 zinc finger protein 419 2 2
MIRT713220 RCAN2 regulator of calcineurin 2 2 2
MIRT713277 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT715008 CYP1B1 cytochrome P450 family 1 subfamily B member 1 2 2
MIRT715051 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT715696 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT717250 TMEM246 transmembrane protein 246 2 2
MIRT717322 PGK1 phosphoglycerate kinase 1 2 2
MIRT717587 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like 2 2
MIRT718122 CHST4 carbohydrate sulfotransferase 4 2 2
MIRT718418 CALN1 calneuron 1 2 2
MIRT718750 ZNF490 zinc finger protein 490 2 2
MIRT720048 PPP1R3F protein phosphatase 1 regulatory subunit 3F 2 2
MIRT721497 THRB thyroid hormone receptor beta 2 2
MIRT722531 EPRS glutamyl-prolyl-tRNA synthetase 2 2
MIRT723279 KRTAP21-2 keratin associated protein 21-2 2 2
MIRT724813 MSX2 msh homeobox 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6509-3p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6509-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6509-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6509-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6509-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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