pre-miRNA Information
pre-miRNA hsa-mir-4301   
Genomic Coordinates chr11: 113450023 - 113450088
Description Homo sapiens miR-4301 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4301
Sequence 11| UCCCACUACUUCACUUGUGA |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs184176277 2 dbSNP
rs1191324913 13 dbSNP
rs1369198005 15 dbSNP
rs1036973189 16 dbSNP
rs944900541 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZC2HC1C   
Synonyms C14orf140, FAM164C
Description zinc finger C2HC-type containing 1C
Transcript NM_001042430   
Other Transcripts NM_024643   
Expression
Putative miRNA Targets on ZC2HC1C
3'UTR of ZC2HC1C
(miRNA target sites are highlighted)
>ZC2HC1C|NM_001042430|3'UTR
   1 ACCTCCTCAGAAGAGCAACTGGAGATAGAAGCATGAATCTTTTATCCATACGTTCCGCCAGGCTCGAGAGGTCCAGCAGG
  81 TAACTGCCAAAGGTGGAAACTGTTCACACTTGCCTCCCATCCTGCCTGCAGAAAACCCAGACTGCATTCAGTGTCCTCAG
 161 TGTAGCCACCACTTTGCTCCCAAGGTGGCTGAGCAACACATTCCCAAGTGTAAGACCATCAAGAACTGTCTTCCACCTCT
 241 AAGGAAGCATTATAGTTGAGCAGACAACAATGGAAACTTTTGGATAGTTCAGAAAGCTCTGCTTCTCTTCAGCAGTAAAT
 321 GGGAGTAGAATTTGATGCAAAGCAGAAAGAAATCAAACAGCTCCCAGATCTGCCTGCAGAGCTAAAATCTGTGAGGAGAG
 401 AGCCACTGCTAAGCAGCAGGAGGCAGAAGGAAGCCCCAGCTTCCCACTAAATTACAACCTTGGGCTGGTATGCTTTATGT
 481 TATTGCCCTCAGAATTGATGGGTGAAGACACTGAAGAGTCATGAGCAGGCTCCATTAAAGCTCTTTTCTTGCATGCCTGA
 561 CTTGTGGTTTGTGCTAGTTAAGTGCCTGCATCTGGTTCTGCCTTCTTGTCACTGCATGTATGTTCAGAGTTCCTGTTAAC
 641 TCTTGCTTTTGTAGAAGCTGGAGTTATTAGGATGTGTTGGTGTCAGAGGGGCATGATCACCCAGATAGTAACTCTTATAA
 721 AAGATAATACAATTTTGCTATAAGGCATTATTAATGGAAATCTATCCTTGGTCTCCCTGGTGCATAAGCCTGGCCAAAAC
 801 CCAATACAAGTATGTAAGGTTAAGGCACCAATGTCTCCTAAACCTTCCCTATGGTGTACTGTGTAATAAAGGAAAGATCT
 881 TTATGTACTTTACAGGGTAGGGATGGGTGTTGGGGGGGAAACACATTATACTTCTCTCTACTTGTTCTTTTCTAATGGGT
 961 TTCATATGTTAAGAAAGAAACCTCCATTTTAGCTGTTAGTAGCACTCTACTTTCAAATCGGTTTGGCTAAATGACTGTTT
1041 AGAGGCAGCAAAATCTACCATCAAAGCAAGCTGAGACAGGCTGGTCATGGTGGCTCATTCCTATAATTCCAGCACTTTGG
1121 GAGGCTGAAGTGGGAGGATTGCTTGAGGCCAGGAGTTCAAGAGCGGCCTCGACAACAAAGCAAGACCCCATCTCAAAACA
1201 AAACAAAGCTGGGACACTGCACAGTGTCACATGCCCTTGGCAATTATAGCATAGTCAACTTCTATTTCAGAGAGTAAACT
1281 TTGAAGGGAAAGGGATCAAATCTTTTTAATTTTCTCTGTGTAGAATATTGCCTAGCACAAGTTAGACCTTCAATTAGTGA
1361 GGTCTGGAGATTTAAAATTAAACAAGAAGATGAGTGAGTCCTACACTAGTGAAATCAGAGAACTGATAAGTTAATGTCTG
1441 CGAGAGTATTATCAGTTCAGATAGGAGTGAAGTTAGCACAACAGATAGAAATCTTAGGATTACTGTTCTGTATTACTCAA
1521 ATTGTTAGTTTAAAATACTGGAGAAAAACTGCTCAATTTGAGCTAGTCAACAGGGCTAGACAGACAACAAAATCCTATTT
1601 TACTAAGTAACAAATGGCCACTCACTCTTGCTCCATTTCCACTGCACTCCAGCCTGGTGACCTAGTGAGACTCCATCTCA
1681 AAAAAAAAAAAAAAAAAAAGAAAAAAAAATTGGGCTAACAGATCAGACCAATTTGAAATGTGAGTTAAGGCTTTAGCGGT
1761 GAAGCTGCAGGACACAGGCTGGGAAAAAATCCTATATATTTAAATAGGAGCACACATTTCTTTGCACTCTTTTTAATTGT
1841 TCCAAAGGAAAGGAGGTATCACATAATAAAGCTTTATGGTTAGCCCCTTAAGGAAACCTCACACAGAGATAATGGATATT
1921 TAACCTAATAGGTACATTCCCTAGGCAAGTTCAATGAAATGTACACTTTAAGTGGGAATGTAAACCAGTACATTGCAATA
2001 GATGGCAAGAGTAAGCTGTGGCCAAGGTCACAAAATGGCAACATGTGGATTGCTTTGCTCCACAGATGTTTTATTTCGCT
2081 GGCCTAGCATTCATAATATGATCTGACATTTAAAAACTGGGATATGGAACATCTCTTGAAAAACTGGAAGTTCTGGAAAC
2161 ACTGGGCCAGCAACCCGCATGGCACAAATTGGGTGGGGTTTAGAATCAGATGCTCCTCCAGATGGGAATGGTAGCACCAG
2241 ACCACTGCAGTCTCACTTGGCCTGCTTCACTTCTTTACCTTATCTGCCTGGTACCACAGGCACTTGGATTTGGGATCGCT
2321 GGATGTTAGTAAGGTCATAGATCCGGGCCCTCCAGAGAGAACAAATTGTTGTTATATGTGGGGAGTGCTTTCTAAAAAGG
2401 AAGCAGTTGTTTGCTCTCATTTTGCTAAAGAAATAAAACAATAGTCAATGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aguGUUCACUUCAUCACCCu 5'
             | :||||  ||||| | 
Target 5' agcCTGGTGACCTAGTGAGa 3'
1651 - 1670 125.00 -9.90
2
miRNA  3' agUGUUCA--C------UUCAUCACCCu 5'
            ||||||  |      || ||||| | 
Target 5' gcACAAGTTAGACCTTCAATTAGTGAGg 3'
1335 - 1362 122.00 -14.90
3
miRNA  3' aguguucacuucaUCACCCu 5'
                       |||||| 
Target 5' tttgggaggctgaAGTGGGa 3'
1116 - 1135 120.00 -13.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM957957 29 COSMIC
COSN27005525 43 COSMIC
COSN30501095 53 COSMIC
COSN30106702 60 COSMIC
COSN30520445 72 COSMIC
COSN31496480 80 COSMIC
COSN23014691 96 COSMIC
COSN8588953 98 COSMIC
COSN30508413 129 COSMIC
COSN19660250 232 COSMIC
COSN15576286 448 COSMIC
COSN22886341 493 COSMIC
COSN24273115 505 COSMIC
COSN31779027 563 COSMIC
COSN216789 567 COSMIC
COSN1659319 741 COSMIC
COSN20687047 896 COSMIC
COSN20217133 1128 COSMIC
COSN16352676 1616 COSMIC
COSN16353127 1618 COSMIC
COSN22403731 1630 COSMIC
COSN14549788 1697 COSMIC
COSN25393724 1827 COSMIC
COSN15984692 1851 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1018764004 3 dbSNP
rs750660585 7 dbSNP
rs901965771 10 dbSNP
rs1247029342 11 dbSNP
rs781145086 13 dbSNP
rs745658680 14 dbSNP
rs1265330124 17 dbSNP
rs769532515 21 dbSNP
rs996269777 23 dbSNP
rs775367837 25 dbSNP
rs536282928 27 dbSNP
rs1403772749 32 dbSNP
rs1466486002 33 dbSNP
rs151087313 36 dbSNP
rs768947145 39 dbSNP
rs190763788 44 dbSNP
rs377098657 46 dbSNP
rs768137335 52 dbSNP
rs773917412 53 dbSNP
rs761263113 57 dbSNP
rs766589552 58 dbSNP
rs1229629621 60 dbSNP
rs370528322 62 dbSNP
rs373541035 64 dbSNP
rs376265959 66 dbSNP
rs751035983 67 dbSNP
rs1488599395 69 dbSNP
rs756825851 72 dbSNP
rs1167914943 73 dbSNP
rs985052328 97 dbSNP
rs1425267890 110 dbSNP
rs1171481949 117 dbSNP
rs1453181105 120 dbSNP
rs1240545346 122 dbSNP
rs933782640 130 dbSNP
rs1015210232 142 dbSNP
rs1430126110 147 dbSNP
rs377734077 152 dbSNP
rs1338381260 153 dbSNP
rs1212522920 155 dbSNP
rs1312920682 161 dbSNP
rs558479610 167 dbSNP
rs1217532862 172 dbSNP
rs992775478 173 dbSNP
rs756315275 178 dbSNP
rs1311414720 180 dbSNP
rs17493927 211 dbSNP
rs1375900864 227 dbSNP
rs10246 232 dbSNP
rs946434497 237 dbSNP
rs1359369389 245 dbSNP
rs554670733 262 dbSNP
rs1207773306 264 dbSNP
rs772531935 269 dbSNP
rs1447166393 274 dbSNP
rs902814813 284 dbSNP
rs374331651 293 dbSNP
rs999735793 297 dbSNP
rs1406242011 317 dbSNP
rs574576397 321 dbSNP
rs377004760 326 dbSNP
rs1237090659 346 dbSNP
rs749003784 350 dbSNP
rs1189343566 351 dbSNP
rs1489327309 357 dbSNP
rs1286762395 362 dbSNP
rs1291015353 364 dbSNP
rs935641001 379 dbSNP
rs1304677538 395 dbSNP
rs1012807106 399 dbSNP
rs540272029 402 dbSNP
rs891732305 407 dbSNP
rs945985107 411 dbSNP
rs1023742984 413 dbSNP
rs1412484182 421 dbSNP
rs1474434491 422 dbSNP
rs1160601992 426 dbSNP
rs1298197959 434 dbSNP
rs1385979683 434 dbSNP
rs931877962 434 dbSNP
rs1400304618 437 dbSNP
rs984842623 440 dbSNP
rs1014930416 446 dbSNP
rs961999965 447 dbSNP
rs1316458471 448 dbSNP
rs972652142 448 dbSNP
rs1040646879 454 dbSNP
rs922483861 458 dbSNP
rs901644620 467 dbSNP
rs996278314 468 dbSNP
rs1485532259 469 dbSNP
rs770522985 472 dbSNP
rs1322126899 474 dbSNP
rs1272249398 486 dbSNP
rs887845577 489 dbSNP
rs3742776 496 dbSNP
rs774181905 497 dbSNP
rs141018737 502 dbSNP
rs1354673647 503 dbSNP
rs1242369208 505 dbSNP
rs181640653 512 dbSNP
rs1359206384 514 dbSNP
rs867077496 517 dbSNP
rs1458818112 518 dbSNP
rs755487425 519 dbSNP
rs962642340 523 dbSNP
rs759321141 527 dbSNP
rs1163225150 535 dbSNP
rs562958385 544 dbSNP
rs1222901360 553 dbSNP
rs1424582841 555 dbSNP
rs1193093949 558 dbSNP
rs1283425349 568 dbSNP
rs933857065 573 dbSNP
rs985685629 580 dbSNP
rs992388217 591 dbSNP
rs1488726394 593 dbSNP
rs116283675 594 dbSNP
rs969561035 597 dbSNP
rs979834999 618 dbSNP
rs1043417521 619 dbSNP
rs1319617100 619 dbSNP
rs1226179902 622 dbSNP
rs150247478 624 dbSNP
rs61980803 630 dbSNP
rs1387928162 641 dbSNP
rs1056661923 645 dbSNP
rs1324360663 650 dbSNP
rs896710640 652 dbSNP
rs1157112458 662 dbSNP
rs1401434581 668 dbSNP
rs989816404 675 dbSNP
rs1012444235 678 dbSNP
rs912892367 689 dbSNP
rs1460603557 694 dbSNP
rs945963563 707 dbSNP
rs140925872 711 dbSNP
rs546280750 717 dbSNP
rs1040254251 719 dbSNP
rs1176868687 725 dbSNP
rs566420490 732 dbSNP
rs1191555742 738 dbSNP
rs931829009 741 dbSNP
rs1050231552 742 dbSNP
rs374036003 743 dbSNP
rs1194879109 747 dbSNP
rs1479451704 782 dbSNP
rs1257311506 785 dbSNP
rs175493 787 dbSNP
rs185164343 788 dbSNP
rs962051439 805 dbSNP
rs1242884757 808 dbSNP
rs764262806 811 dbSNP
rs1328518819 813 dbSNP
rs1029615392 818 dbSNP
rs955463866 819 dbSNP
rs1238056521 820 dbSNP
rs1306637376 824 dbSNP
rs1014273000 825 dbSNP
rs144589348 827 dbSNP
rs1171702258 832 dbSNP
rs56050685 837 dbSNP
rs1380755251 838 dbSNP
rs1180806299 852 dbSNP
rs570850086 853 dbSNP
rs979167118 853 dbSNP
rs554335060 864 dbSNP
rs745586801 869 dbSNP
rs1200640598 870 dbSNP
rs757598787 885 dbSNP
rs1002351165 888 dbSNP
rs1032471889 892 dbSNP
rs1277495391 904 dbSNP
rs1342227899 905 dbSNP
rs539564498 912 dbSNP
rs935023486 912 dbSNP
rs957155228 914 dbSNP
rs1251859317 919 dbSNP
rs1437610976 920 dbSNP
rs1342529122 921 dbSNP
rs1177095899 925 dbSNP
rs1414337867 925 dbSNP
rs1373716349 933 dbSNP
rs1255147004 939 dbSNP
rs918208170 948 dbSNP
rs1454841971 957 dbSNP
rs1361069646 977 dbSNP
rs1468441016 978 dbSNP
rs765521929 978 dbSNP
rs175492 982 dbSNP
rs138543059 984 dbSNP
rs780227874 991 dbSNP
rs568186803 994 dbSNP
rs141837579 1001 dbSNP
rs1195190760 1003 dbSNP
rs577137262 1014 dbSNP
rs923234888 1016 dbSNP
rs1397044215 1020 dbSNP
rs76558511 1034 dbSNP
rs1203859569 1041 dbSNP
rs1358933081 1044 dbSNP
rs1266337905 1045 dbSNP
rs1232976643 1047 dbSNP
rs1353784582 1055 dbSNP
rs1280231541 1082 dbSNP
rs1036466442 1084 dbSNP
rs1317975991 1086 dbSNP
rs1325894680 1090 dbSNP
rs1317588604 1091 dbSNP
rs897892912 1097 dbSNP
rs1156521339 1099 dbSNP
rs175491 1109 dbSNP
rs909011955 1110 dbSNP
rs1441236471 1111 dbSNP
rs532029715 1120 dbSNP
rs953366720 1128 dbSNP
rs1240962964 1138 dbSNP
rs145605987 1140 dbSNP
rs1453830574 1144 dbSNP
rs1268567147 1149 dbSNP
rs1213435777 1156 dbSNP
rs562213983 1162 dbSNP
rs865967173 1164 dbSNP
rs1018164988 1165 dbSNP
rs968306472 1166 dbSNP
rs897833776 1171 dbSNP
rs923719297 1172 dbSNP
rs1197177625 1173 dbSNP
rs1013618162 1181 dbSNP
rs1332741870 1186 dbSNP
rs1046812450 1192 dbSNP
rs917574001 1194 dbSNP
rs1193302177 1200 dbSNP
rs1391964922 1207 dbSNP
rs1332974668 1209 dbSNP
rs1410124999 1211 dbSNP
rs905492559 1213 dbSNP
rs1418256041 1214 dbSNP
rs1002405040 1219 dbSNP
rs1165640099 1229 dbSNP
rs370137848 1251 dbSNP
rs555273367 1251 dbSNP
rs947712579 1255 dbSNP
rs1045740043 1265 dbSNP
rs1240354756 1268 dbSNP
rs74871011 1269 dbSNP
rs1036525951 1282 dbSNP
rs1271039697 1283 dbSNP
rs958161678 1284 dbSNP
rs1436795269 1290 dbSNP
rs1465003786 1309 dbSNP
rs897951897 1310 dbSNP
rs997603951 1322 dbSNP
rs543141028 1324 dbSNP
rs1233410160 1328 dbSNP
rs1396480091 1339 dbSNP
rs1461761094 1346 dbSNP
rs777367384 1348 dbSNP
rs748725052 1354 dbSNP
rs1442564701 1363 dbSNP
rs1353537321 1380 dbSNP
rs554011181 1384 dbSNP
rs1018633440 1386 dbSNP
rs1375473524 1388 dbSNP
rs967927038 1389 dbSNP
rs1383435384 1393 dbSNP
rs1453049153 1395 dbSNP
rs1382619601 1399 dbSNP
rs546638959 1401 dbSNP
rs112922009 1403 dbSNP
rs1178126182 1408 dbSNP
rs967512458 1416 dbSNP
rs1000686640 1419 dbSNP
rs1325318957 1427 dbSNP
rs759357280 1427 dbSNP
rs956497616 1431 dbSNP
rs188994665 1442 dbSNP
rs1345626191 1443 dbSNP
rs1224099864 1447 dbSNP
rs175490 1447 dbSNP
rs1455028114 1449 dbSNP
rs1295637401 1456 dbSNP
rs368299395 1468 dbSNP
rs980444878 1472 dbSNP
rs953282966 1480 dbSNP
rs1277437217 1483 dbSNP
rs1449698742 1485 dbSNP
rs1355550470 1499 dbSNP
rs745465567 1501 dbSNP
rs909482945 1503 dbSNP
rs1362979711 1512 dbSNP
rs942258635 1516 dbSNP
rs1213387907 1520 dbSNP
rs909064161 1523 dbSNP
rs941815655 1541 dbSNP
rs1183830609 1542 dbSNP
rs1475619074 1555 dbSNP
rs972296184 1557 dbSNP
rs181053930 1565 dbSNP
rs1185874452 1569 dbSNP
rs972271554 1584 dbSNP
rs919372501 1596 dbSNP
rs1285202114 1605 dbSNP
rs532160756 1625 dbSNP
rs372226041 1630 dbSNP
rs919434071 1638 dbSNP
rs1281804396 1640 dbSNP
rs545927345 1643 dbSNP
rs1355678656 1647 dbSNP
rs1052301904 1648 dbSNP
rs1412343725 1658 dbSNP
rs889190530 1668 dbSNP
rs1222379063 1669 dbSNP
rs1261180548 1672 dbSNP
rs905171659 1675 dbSNP
rs1430570893 1677 dbSNP
rs1343806956 1678 dbSNP
rs1167343105 1679 dbSNP
rs1491489600 1679 dbSNP
rs1187047444 1680 dbSNP
rs1215307008 1680 dbSNP
rs1240202000 1680 dbSNP
rs1272182305 1680 dbSNP
rs1335118425 1680 dbSNP
rs1417381961 1680 dbSNP
rs1485502044 1680 dbSNP
rs1491144384 1680 dbSNP
rs577407645 1680 dbSNP
rs66560922 1680 dbSNP
rs752525531 1680 dbSNP
rs760983748 1680 dbSNP
rs776737044 1680 dbSNP
rs1231018405 1681 dbSNP
rs1319403411 1685 dbSNP
rs1295592156 1689 dbSNP
rs938269871 1692 dbSNP
rs1476871899 1694 dbSNP
rs1053941801 1695 dbSNP
rs1442140296 1697 dbSNP
rs894046916 1697 dbSNP
rs1043055637 1698 dbSNP
rs1191495602 1699 dbSNP
rs1324157329 1699 dbSNP
rs1373789913 1700 dbSNP
rs369733279 1700 dbSNP
rs1195379197 1701 dbSNP
rs1417256369 1701 dbSNP
rs72736217 1701 dbSNP
rs1009759747 1702 dbSNP
rs1252081059 1704 dbSNP
rs1021535346 1706 dbSNP
rs902964229 1707 dbSNP
rs1475418398 1710 dbSNP
rs1163744665 1711 dbSNP
rs1481408351 1741 dbSNP
rs997640774 1745 dbSNP
rs1347786353 1747 dbSNP
rs1251443379 1756 dbSNP
rs568852405 1758 dbSNP
rs374803565 1759 dbSNP
rs1306301648 1764 dbSNP
rs1235584835 1765 dbSNP
rs953000335 1769 dbSNP
rs1370727224 1772 dbSNP
rs1359407759 1781 dbSNP
rs1000738359 1784 dbSNP
rs531777624 1785 dbSNP
rs1315359149 1793 dbSNP
rs1449357997 1796 dbSNP
rs1356598322 1809 dbSNP
rs775106299 1811 dbSNP
rs1310980147 1816 dbSNP
rs1030839860 1817 dbSNP
rs1360915402 1818 dbSNP
rs1175450821 1824 dbSNP
rs892312654 1827 dbSNP
rs551313615 1828 dbSNP
rs1394321215 1835 dbSNP
rs1191502424 1844 dbSNP
rs73309772 1852 dbSNP
rs1025167249 1857 dbSNP
rs942105262 1859 dbSNP
rs969150598 1863 dbSNP
rs758332882 1867 dbSNP
rs1487390218 1868 dbSNP
rs1213036633 1880 dbSNP
rs1194826862 1886 dbSNP
rs980885666 1888 dbSNP
rs1281764397 1898 dbSNP
rs1259553702 1905 dbSNP
rs1212314374 1909 dbSNP
rs963608846 1914 dbSNP
rs76638980 1919 dbSNP
rs1203188404 1930 dbSNP
rs1241579929 1932 dbSNP
rs534050250 1935 dbSNP
rs1306585373 1950 dbSNP
rs1411416604 1955 dbSNP
rs1420640016 1959 dbSNP
rs1389829610 1962 dbSNP
rs1357450571 1971 dbSNP
rs1313553027 1977 dbSNP
rs1435328272 1990 dbSNP
rs12431669 1992 dbSNP
rs1171639194 1993 dbSNP
rs544375528 1995 dbSNP
rs982568152 1999 dbSNP
rs933501302 2000 dbSNP
rs926645699 2004 dbSNP
rs175489 2012 dbSNP
rs1259079611 2029 dbSNP
rs1174920721 2037 dbSNP
rs910663442 2042 dbSNP
rs943462935 2043 dbSNP
rs1207355343 2045 dbSNP
rs1351862985 2050 dbSNP
rs1043493929 2051 dbSNP
rs539859508 2077 dbSNP
rs1237238609 2078 dbSNP
rs372908188 2079 dbSNP
rs894097909 2084 dbSNP
rs934631688 2088 dbSNP
rs1052320964 2091 dbSNP
rs1353592054 2093 dbSNP
rs867648037 2097 dbSNP
rs1042567756 2098 dbSNP
rs761975835 2102 dbSNP
rs1013864915 2104 dbSNP
rs1024799966 2108 dbSNP
rs1157771650 2113 dbSNP
rs904986092 2133 dbSNP
rs1419536003 2137 dbSNP
rs1165142955 2138 dbSNP
rs760890716 2148 dbSNP
rs901296748 2155 dbSNP
rs997293429 2163 dbSNP
rs1209404670 2164 dbSNP
rs765616955 2168 dbSNP
rs1481495239 2177 dbSNP
rs1030056491 2178 dbSNP
rs1470025053 2187 dbSNP
rs1274065996 2189 dbSNP
rs1237211656 2194 dbSNP
rs963059578 2199 dbSNP
rs993146667 2216 dbSNP
rs888855943 2231 dbSNP
rs1026598555 2234 dbSNP
rs1175096475 2239 dbSNP
rs1432676881 2247 dbSNP
rs1396340446 2253 dbSNP
rs753935346 2265 dbSNP
rs988086004 2266 dbSNP
rs1007256851 2271 dbSNP
rs1411077695 2278 dbSNP
rs1413399613 2279 dbSNP
rs1169129037 2282 dbSNP
rs1476054305 2283 dbSNP
rs556278408 2290 dbSNP
rs576808745 2301 dbSNP
rs1455866938 2308 dbSNP
rs750691751 2309 dbSNP
rs4899544 2318 dbSNP
rs766798605 2319 dbSNP
rs1331047397 2329 dbSNP
rs926015367 2334 dbSNP
rs1196425891 2339 dbSNP
rs541488658 2343 dbSNP
rs4903279 2345 dbSNP
rs1053034409 2346 dbSNP
rs913854236 2361 dbSNP
rs972359394 2365 dbSNP
rs756956927 2366 dbSNP
rs753190338 2372 dbSNP
rs1367076604 2375 dbSNP
rs1347733365 2377 dbSNP
rs1026150948 2381 dbSNP
rs572647217 2386 dbSNP
rs1330354458 2393 dbSNP
rs1410073166 2396 dbSNP
rs949335522 2405 dbSNP
rs970946695 2409 dbSNP
rs1455964901 2410 dbSNP
rs982177014 2415 dbSNP
rs1396128392 2423 dbSNP
rs905038959 2424 dbSNP
rs1477187732 2428 dbSNP
rs1276432281 2431 dbSNP
rs116352378 2440 dbSNP
rs549895997 2443 dbSNP
rs1270884788 2445 dbSNP
rs1257234861 2449 dbSNP
rs989472143 2453 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' aguguucacuucaUCACCCu 5'
                       |||||| 
Target 5' ------------aAGUGGGa 3'
1 - 8
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000238686.8 | 3UTR | AAGUGGGAGGAUUGCUUGAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4301 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081134 LDLR low density lipoprotein receptor 2 4
MIRT090911 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT229436 MECP2 methyl-CpG binding protein 2 2 2
MIRT274717 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT350957 BACH1 BTB domain and CNC homolog 1 2 2
MIRT386722 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT446022 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT481303 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 14
MIRT483959 ZNF354B zinc finger protein 354B 2 6
MIRT495667 TUBAL3 tubulin alpha like 3 2 2
MIRT496554 TBX15 T-box 15 2 2
MIRT497702 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT498105 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT512535 SEMA4D semaphorin 4D 2 2
MIRT512556 MFN2 mitofusin 2 2 6
MIRT521465 RABGAP1 RAB GTPase activating protein 1 2 6
MIRT526236 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526743 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527578 BRD7 bromodomain containing 7 2 4
MIRT528038 WT1 Wilms tumor 1 2 2
MIRT528267 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT528505 HTR7 5-hydroxytryptamine receptor 7 2 4
MIRT528758 RPS27 ribosomal protein S27 2 6
MIRT528999 IPO9 importin 9 2 2
MIRT529701 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529781 C17orf82 chromosome 17 open reading frame 82 2 2
MIRT533797 TMEM119 transmembrane protein 119 2 6
MIRT535308 PHF12 PHD finger protein 12 2 2
MIRT535917 MKL2 MKL1/myocardin like 2 2 2
MIRT544892 OSBPL1A oxysterol binding protein like 1A 2 2
MIRT555423 PPIC peptidylprolyl isomerase C 2 2
MIRT562068 KLHL15 kelch like family member 15 2 2
MIRT565623 SLC31A1 solute carrier family 31 member 1 2 2
MIRT565661 SIX1 SIX homeobox 1 2 2
MIRT570138 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT571045 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT621232 LMAN1 lectin, mannose binding 1 2 2
MIRT622272 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623844 GAN gigaxonin 2 2
MIRT626158 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626464 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT632087 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT637243 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT642710 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT643611 KANSL3 KAT8 regulatory NSL complex subunit 3 2 2
MIRT644270 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 2 2
MIRT645470 SPIN3 spindlin family member 3 2 2
MIRT649193 DNPEP aspartyl aminopeptidase 2 2
MIRT650776 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT651345 ZC2HC1C zinc finger C2HC-type containing 1C 2 2
MIRT652237 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT652587 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654591 PURA purine rich element binding protein A 2 2
MIRT654649 PTAFR platelet activating factor receptor 2 2
MIRT656842 KLF7 Kruppel like factor 7 2 2
MIRT657209 IKZF2 IKAROS family zinc finger 2 2 2
MIRT658513 ETV3 ETS variant 3 2 2
MIRT659448 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT668816 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT669067 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT677711 ELOF1 elongation factor 1 homolog 2 4
MIRT687146 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT698498 THOC2 THO complex 2 2 2
MIRT707930 PPP1R3D protein phosphatase 1 regulatory subunit 3D 4 2
MIRT708737 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT710031 POLL DNA polymerase lambda 2 2
MIRT712175 STK4 serine/threonine kinase 4 2 2
MIRT715297 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT716892 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT717378 RBM41 RNA binding motif protein 41 2 2
MIRT718082 CLIC5 chloride intracellular channel 5 2 2
MIRT718721 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT719152 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719224 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719528 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT719861 KLF2 Kruppel like factor 2 2 2
MIRT720326 CAMK2G calcium/calmodulin dependent protein kinase II gamma 2 2
MIRT721596 SREBF1 sterol regulatory element binding transcription factor 1 2 2
MIRT722020 NEBL nebulette 2 2
MIRT722484 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT722614 TEAD1 TEA domain transcription factor 1 2 2
MIRT723664 RPTN repetin 2 2
MIRT723939 SVOP SV2 related protein 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive High Hepatocellular Carcinoma cell line (Hep3B, 97L)
hsa-miR-4301 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-4301 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-4301 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-4301 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-miR-4301 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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