pre-miRNA Information
pre-miRNA hsa-mir-6511b-1   
Genomic Coordinates chr16: 2106669 - 2106753
Description Homo sapiens miR-6511b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-6511b-2   
Genomic Coordinates chr16: 15134075 - 15134145
Description Homo sapiens miR-6511b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6511b-3p
Sequence 53| CCUCACCACCCCUUCUGCCUGCA |75
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
993639 5 ClinVar
1196654 15 ClinVar
256998 15 ClinVar
433980 16 ClinVar
586295 18 ClinVar
433979 19 ClinVar
COSM3948368 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs769351879 1 dbSNP
rs1001283562 2 dbSNP
rs763611191 3 dbSNP
rs1465530682 4 dbSNP
rs1227492873 4 dbSNP
rs745502224 5 dbSNP
rs551972801 6 dbSNP
rs538162642 6 dbSNP
rs751438298 7 dbSNP
rs1285683081 7 dbSNP
rs1340898267 8 dbSNP
rs4018164 9 dbSNP
rs370568831 9 dbSNP
rs1180919709 10 dbSNP
rs1339482497 10 dbSNP
rs758216756 11 dbSNP
rs1323026290 11 dbSNP
rs1239445091 12 dbSNP
rs1310601001 12 dbSNP
rs1431093969 13 dbSNP
rs752690118 15 dbSNP
rs1371790714 15 dbSNP
rs746463189 16 dbSNP
rs1209415208 17 dbSNP
rs761022804 17 dbSNP
rs1242038386 17 dbSNP
rs370411414 18 dbSNP
rs759723934 19 dbSNP
rs1428318191 19 dbSNP
rs1416441031 20 dbSNP
rs754040914 21 dbSNP
rs776062795 21 dbSNP
rs1273686335 22 dbSNP
rs1182772456 22 dbSNP
rs1472619959 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TIMM8A   
Synonyms DDP, DDP1, DFN1, MTS, TIM8
Description translocase of inner mitochondrial membrane 8A
Transcript NM_004085   
Other Transcripts NM_001145951   
Expression
Putative miRNA Targets on TIMM8A
3'UTR of TIMM8A
(miRNA target sites are highlighted)
>TIMM8A|NM_004085|3'UTR
   1 TCTCAGCATTACCTCTTTGGAAAAGGAAGGTAGTTCAAGAAATGAAGAGCTGTTGATGGGATGATTGAAGAAACAGCTAT
  81 GAGAGGATTGGCTCCCATCTTTTGTTACTCTTGGGACATCCTGTCATCTGAGAATGAACAAAGACCAATTTTTTGTGTGT
 161 GAAGCTTAAGGGTCATATGTTTGCTTGTATTTTTTAATGCTAATCTTGTGAAAATAATTGACAGGCGAAAGAAAACTCTA
 241 TTTAGATGCATATTACTGTACATGGGACTATGCTTTTCTCAAAGCCCCATTAACTGCTTCCTATAATTTTGATAGTGGGA
 321 CCACATACGTAAAAATCTCTCATTTGTGTGGAGTCATTTCTGATTTCAGGGGAGATCCTTGTGTTTATCAGAAAGGGCAG
 401 AAGTAGGGGAAGAATAATTTGGTATCCTTATCTAGTGTTTGATTGTCAATGCTGGAGAAAAATATCTGTAAGAGTGTTTA
 481 TACAGTACACTTCAGTTATCTTGATCTCCCTTTCCTATATGATGATTTGCTTAAATATCCATATTAAGTAAGTCTCAAGG
 561 TAGGGTAGGCAGCCTGAGAGTCTAGAGGCCTTTAGTTATAAAGGAATCTAGCCAGTGAACATAATTCTTATTACTAGACT
 641 GCCACAAGGAAGAAATTAACTTACCCTGTATATCAGGGTACAAAAAATTCAGTGATGTGCCTAAATAAGTTATAAAGATT
 721 TAGGCCAATCAGAAGCTAACAGCAGTTTCAGGTAGAGGTGCATGCCTAATGTTAGTTAGTGTAGATTCCATTTACTGCAT
 801 TCTTCTGATCACTGAAATAAAAGCTATATAAGATTCAACTCTGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGUCCGU--CUUCCCCACCACUcc 5'
            || | |  |||| | || |||  
Target 5' ttCAAGAAATGAAGAGCTGTTGAtg 3'
34 - 58 111.00 -6.70
2
miRNA  3' acgUCCGUCU---UCCCC----------ACCAcucc 5'
             :||||||   |||||          ||||    
Target 5' aaaGGGCAGAAGTAGGGGAAGAATAATTTGGTatcc 3'
392 - 427 98.00 -17.86
3
miRNA  3' acguccgucuuccCCACCACUCc 5'
                       | | |||:| 
Target 5' ttcctataattttGATAGTGGGa 3'
298 - 320 94.00 -5.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
21394 506 ClinVar
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs185711695 25 dbSNP
rs1402589367 26 dbSNP
rs782762708 29 dbSNP
rs782801850 30 dbSNP
rs782214090 43 dbSNP
rs1455861527 46 dbSNP
rs181919155 50 dbSNP
rs1383990084 72 dbSNP
rs1447690258 79 dbSNP
rs1283007618 95 dbSNP
rs2071224 97 dbSNP
rs782076826 121 dbSNP
rs1287134051 122 dbSNP
rs1326405745 128 dbSNP
rs1205209879 129 dbSNP
rs781800592 132 dbSNP
rs1263306666 158 dbSNP
rs1441688216 174 dbSNP
rs1207751757 189 dbSNP
rs1234568207 206 dbSNP
rs3027653 226 dbSNP
rs782638910 227 dbSNP
rs1411362514 240 dbSNP
rs1471610366 245 dbSNP
rs183928551 252 dbSNP
rs1178863987 257 dbSNP
rs1407100680 263 dbSNP
rs368774526 302 dbSNP
rs1414330287 323 dbSNP
rs1332577374 324 dbSNP
rs1356843757 325 dbSNP
rs782017070 328 dbSNP
rs1348092492 329 dbSNP
rs1224803088 343 dbSNP
rs782526107 355 dbSNP
rs1343812319 358 dbSNP
rs1217311681 368 dbSNP
rs1274881402 384 dbSNP
rs782704764 396 dbSNP
rs1249454810 398 dbSNP
rs1482150675 422 dbSNP
rs1201685177 432 dbSNP
rs1378471750 435 dbSNP
rs79564479 436 dbSNP
rs1170988349 437 dbSNP
rs1422135803 443 dbSNP
rs1430726047 447 dbSNP
rs1307975942 466 dbSNP
rs781892837 468 dbSNP
rs1406285231 469 dbSNP
rs1303203720 472 dbSNP
rs1329953369 473 dbSNP
rs782102842 477 dbSNP
rs1271505027 484 dbSNP
rs1339842505 489 dbSNP
rs879947933 493 dbSNP
rs1227373875 499 dbSNP
rs868979856 500 dbSNP
rs868969312 501 dbSNP
rs1331509900 506 dbSNP
rs4024308 506 dbSNP
rs782333734 506 dbSNP
rs868980473 507 dbSNP
rs1361470087 509 dbSNP
rs1224884886 519 dbSNP
rs3027654 521 dbSNP
rs1451070908 523 dbSNP
rs1197030405 529 dbSNP
rs1244003687 530 dbSNP
rs1450554035 535 dbSNP
rs1168319805 539 dbSNP
rs1388913096 581 dbSNP
rs1427133892 583 dbSNP
rs1164299270 590 dbSNP
rs1389392320 606 dbSNP
rs1384504054 617 dbSNP
rs1319941739 627 dbSNP
rs1326655611 630 dbSNP
rs782036530 641 dbSNP
rs1295103258 649 dbSNP
rs1246665825 665 dbSNP
rs1264722467 668 dbSNP
rs1355747684 682 dbSNP
rs1208124631 688 dbSNP
rs371672469 688 dbSNP
rs78682730 688 dbSNP
rs1188110178 703 dbSNP
rs1246605640 719 dbSNP
rs1446750692 724 dbSNP
rs1188866142 745 dbSNP
rs1368383619 752 dbSNP
rs1455988813 755 dbSNP
rs1159767129 760 dbSNP
rs1388990239 775 dbSNP
rs781979163 781 dbSNP
rs1318079187 795 dbSNP
rs1408037885 805 dbSNP
rs1396336725 813 dbSNP
rs375049891 828 dbSNP
rs1242761872 832 dbSNP
rs782301849 832 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acguccgucuuccccaCCACUCc 5'
                          |||||| 
Target 5' -agccgcuccagccugGGUGAGa 3'
1 - 22
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000372902.3 | 3UTR | AGCCGCUCCAGCCUGGGUGAGAGAGUGAGACUCCAUCUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-6511b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059269 CELF1 CUGBP Elav-like family member 1 2 2
MIRT061287 IPO7 importin 7 2 2
MIRT115533 MAZ MYC associated zinc finger protein 2 2
MIRT345986 BIRC5 baculoviral IAP repeat containing 5 2 8
MIRT379536 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT442491 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 2 8
MIRT443701 HUNK hormonally up-regulated Neu-associated kinase 2 4
MIRT459167 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT497179 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT497846 GATA6 GATA binding protein 6 2 4
MIRT519625 ZNF781 zinc finger protein 781 2 2
MIRT519838 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT528560 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT530718 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT530810 GPR182 G protein-coupled receptor 182 2 2
MIRT533265 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT533726 TMEM246 transmembrane protein 246 2 2
MIRT535547 P2RY2 purinergic receptor P2Y2 2 2
MIRT536019 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT539494 ACTN4 actinin alpha 4 2 2
MIRT541793 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2 8
MIRT554509 RUNX1T1 RUNX1 translocation partner 1 2 2
MIRT558784 CEP55 centrosomal protein 55 2 2
MIRT560013 ZNF525 zinc finger protein 525 2 2
MIRT560078 ZNF195 zinc finger protein 195 2 2
MIRT570135 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT570890 ZNF780A zinc finger protein 780A 2 2
MIRT607972 SNX22 sorting nexin 22 2 2
MIRT608104 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT610471 ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 2 4
MIRT611134 GGT7 gamma-glutamyltransferase 7 2 2
MIRT611448 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT613019 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT615753 C6 complement C6 2 2
MIRT620464 CERS6 ceramide synthase 6 2 2
MIRT632248 VPS41 VPS41, HOPS complex subunit 2 2
MIRT636099 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT637452 ZNF324B zinc finger protein 324B 2 2
MIRT638927 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT646768 WDR3 WD repeat domain 3 2 2
MIRT652610 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT652868 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT653655 SLC27A4 solute carrier family 27 member 4 2 2
MIRT657089 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657884 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT662919 MED18 mediator complex subunit 18 2 2
MIRT685622 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT687427 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT692304 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT695127 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695144 PRY PTPN13-like, Y-linked 2 2
MIRT696286 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT699350 SLC35E1 solute carrier family 35 member E1 2 2
MIRT709901 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT710877 SLC25A42 solute carrier family 25 member 42 2 2
MIRT711365 MED7 mediator complex subunit 7 2 2
MIRT711444 FRMPD3 FERM and PDZ domain containing 3 2 2
MIRT713221 RCAN2 regulator of calcineurin 2 2 2
MIRT713281 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT714195 TRAF7 TNF receptor associated factor 7 2 2
MIRT715152 IL12B interleukin 12B 2 2
MIRT719197 CASP10 caspase 10 2 2
MIRT719469 SRF serum response factor 2 2
MIRT720197 MPP6 membrane palmitoylated protein 6 2 2
MIRT720449 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720461 RAB31 RAB31, member RAS oncogene family 2 2
MIRT721646 ZNF207 zinc finger protein 207 2 2
MIRT722001 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT725521 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6511b-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-6511b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6511b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6511b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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