miRTarBase - #MIRT652734


—
pre-miRNA Information
pre-miRNA hsa-mir-378f   
Genomic Coordinates chr1: 23929070 - 23929147
Description Homo sapiens miR-378f stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378f
Sequence 52| ACUGGACUUGGAGCCAGAAG |71
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 18 1 + 23929138 29233923 MiREDiBase
A-to-I 19 1 + 23929139 29233923 MiREDiBase
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TGFB2   
Synonyms G-TSF, LDS4, TGF-beta2
Description transforming growth factor beta 2
Transcript NM_001135599   
Other Transcripts NM_003238   
Expression
Putative miRNA Targets on TGFB2
3'UTR of TGFB2
(miRNA target sites are highlighted)		 
>TGFB2|NM_001135599|3'UTR
   1 AATTCTTGGAAAAGTGGCAAGACCAAAATGACAATGATGATGATAATGATGATGACGACGACAACGATGATGCTTGTAAC
  81 AAGAAAACATAAGAGAGCCTTGGTTCATCAGTGTTAAAAAATTTTTGAAAAGGCGGTACTAGTTCAGACACTTTGGAAGT
 161 TTGTGTTCTGTTTGTTAAAACTGGCATCTGACACAAAAAAAGTTGAAGGCCTTATTCTACATTTCACCTACTTTGTAAGT
 241 GAGAGAGACAAGAAGCAAATTTTTTTTAAAGAAAAAAATAAACACTGGAAGAATTTATTAGTGTTAATTATGTGAACAAC
 321 GACAACAACAACAACAACAACAAACAGGAAAATCCCATTAAGTGGAGTTGCTGTACGTACCGTTCCTATCCCGCGCCTCA
 401 CTTGATTTTTCTGTATTGCTATGCAATAGGCACCCTTCCCATTCTTACTCTTAGAGTTAACAGTGAGTTATTTATTGTGT
 481 GTTACTATATAATGAACGTTTCATTGCCCTTGGAAAATAAAACAGGTGTATAAAGTGGAGACCAAATACTTTGCCAGAAA
 561 CTCATGGATGGCTTAAGGAACTTGAACTCAAACGAGCCAGAAAAAAAGAGGTCATATTAATGGGATGAAAACCCAAGTGA
 641 GTTATTATATGACCGAGAAAGTCTGCATTAAGATAAAGACCCTGAAAACACATGTTATGTATCAGCTGCCTAAGGAAGCT
 721 TCTTGTAAGGTCCAAAAACTAAAAAGACTGTTAATAAAAGAAACTTTCAGTCAGAATAAGTCTGTAAGTTTTTTTTTTTC
 801 TTTTTAATTGTAAATGGTTCTTTGTCAGTTTAGTAAACCAGTGAAATGTTGAAATGTTTTGACATGTACTGGTCAAACTT
 881 CAGACCTTAAAATATTGCTGTATAGCTATGCTATAGGTTTTTTCCTTTGTTTTGGTATATGTAACCATACCTATATTATT
 961 AAAATAGATGGATATAGAAGCCAGCATAATTGAAAACACATCTGCAGATCTCTTTTGCAAACTATTAAATCAAAACATTA
1041 ACTACTTTATGTGTAATGTGTAAATTTTTACCATATTTTTTATATTCTGTAATAATGTCAACTATGATTTAGATTGACTT
1121 AAATTTGGGCTCTTTTTAATGATCACTCACAAATGTATGTTTCTTTTAGCTGGCCAGTACTTTTGAGTAAAGCCCCTATA
1201 GTTTGACTTGCACTACAAATGCATTTTTTTTTTAATAACATTTGCCCTACTTGTGCTTTGTGTTTCTTTCATTATTATGA
1281 CATAAGCTACCTGGGTCCACTTGTCTTTTCTTTTTTTTGTTTCACAGAAAAGATGGGTTCGAGTTCAGTGGTCTTCATCT
1361 TCCAAGCATCATTACTAACCAAGTCAGACGTTAACAAATTTTTATGTTAGGAAAAGGAGGAATGTTATAGATACATAGAA
1441 AATTGAAGTAAAATGTTTTCATTTTAGCAAGGATTTAGGGTTCTAACTAAAACTCAGAATCTTTATTGAGTTAAGAAAAG
1521 TTTCTCTACCTTGGTTTAATCAATATTTTTGTAAAATCCTATTGTTATTACAAAGAGGACACTTCATAGGAAACATCTTT
1601 TTCTTTAGTCAGGTTTTTAATATTCAGGGGGAAATTGAAAGATATATATTTTAGTCGATTTTTCAAAAGGGGAAAAAAGT
1681 CCAGGTCAGCATAAGTCATTTTGTGTATTTCACTGAAGTTATAAGGTTTTTATAAATGTTCTTTGAAGGGGAAAAGGCAC
1761 AAGCCAATTTTTCCTATGATCAAAAAATTCTTTCTTTCCTCTGAGTGAGAGTTATCTATATCTGAGGCTAAAGTTTACCT
1841 TGCTTTAATAAATAATTTGCCACATCATTGCAGAAGAGGTATCCTCATGCTGGGGTTAATAGAATATGTCAGTTTATCAC
1921 TTGTCGCTTATTTAGCTTTAAAATAAAAATTAATAGGCAAAGCAATGGAATATTTGCAGTTTCACCTAAAGAGCAGCATA
2001 AGGAGGCGGGAATCCAAAGTGAAGTTGTTTGATATGGTCTACTTCTTTTTTGGAATTTCCTGACCATTAATTAAAGAATT
2081 GGATTTGCAAGTTTGAAAACTGGAAAAGCAAGAGATGGGATGCCATAATAGTAAACAGCCCTTGTGTTGGATGTAACCCA
2161 ATCCCAGATTTGAGTGTGTGTTGATTATTTTTTTGTCTTCCACTTTTCTATTATGTGTAAATCACTTTTATTTCTGCAGA
2241 CATTTTCCTCTCAGATAGGATGACATTTTGTTTTGTATTATTTTGTCTTTCCTCATGAATGCACTGATAATATTTTAAAT
2321 GCTCTATTTTAAGATCTCTTGAATCTGTTTTTTTTTTTTTTAATTTGGGGGTTCTGTAAGGTCTTTATTTCCCATAAGTA
2401 AATATTGCCATGGGAGGGGGGTGGAGGTGGCAAGGAAGGGGTGAAGTGCTAGTATGCAAGTGGGCAGCAATTATTTTTGT
2481 GTTAATCAGCAGTACAATTTGATCGTTGGCATGGTTAAAAAATGGAATATAAGATTAGCTGTTTTGTATTTTGATGACCA
2561 ATTACGCTGTATTTTAACACGATGTATGTCTGTTTTTGTGGTGCTCTAGTGGTAAATAAATTATTTCGATGATATGTGGA
2641 TGTCTTTTTCCTATCAGTACCATCATCGAGTCTAGAAAACACCTGTGATGCAATAAGACTATCTCAAGCTGGAAAAGTCA
2721 TACCACCTTTCCGATTGCCCTCTGTGCTTTCTCCCTTAAGGACAGTCACTTCAGAAGTCATGCTTTAAAGCACAAGAGTC
2801 AGGCCATATCCATCAAGGATAGAAGAAATCCCTGTGCCGTCTTTTTATTCCCTTATTTATTGCTATTTGGTAATTGTTTG
2881 AGATTTAGTTTCCATCCAGCTTGACTGCCGACCAGAAAAAATGCAGAGAGATGTTTGCACCATGCTTTGGCTTTCTGGTT
2961 CTATGTTCTGCCAACGCCAGGGCCAAAAGAACTGGTCTAGACAGTATCCCCTGTAGCCCCATAACTTGGATAGTTGCTGA
3041 GCCAGCCAGATATAACAAGAGCCACGTGCTTTCTGGGGTTGGTTGTTTGGGATCAGCTACTTGCCTGTCAGTTTCACTGG
3121 TACCACTGCACCACAAACAAAAAAACCCACCCTATTTCCTCCAATTTTTTTGGCTGCTACCTACAAGACCAGACTCCTCA
3201 AACGAGTTGCCAATCTCTTAATAAATAGGATTAATAAAAAAAGTAATTGTGACTCAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaagACCGAGGUUCAGGUCa 5'
              ||| |:|:|||:||| 
Target 5' aagaTGGGTTCGAGTTCAGt 3'
 1330 - 1349 148.00 -21.10
2 
miRNA  3' gaagaccgaggUUCAGGUCa 5'
                     |||||||| 
Target 5' aaaggggaaaaAAGTCCAGg 3'
 1666 - 1685 145.00 -14.70
3 
miRNA  3' gaagaCCG--AGGUUCAGGUCa 5'
               |||  | | |||:||| 
Target 5' gaaaaGGCGGTACTAGTTCAGa 3'
 127 - 148 133.00 -12.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
383972 10 ClinVar
381041 16 ClinVar
873707 22 ClinVar
295495 40 ClinVar
295496 46 ClinVar
295497 136 ClinVar
873708 194 ClinVar
295498 202 ClinVar
295499 322 ClinVar
874678 339 ClinVar
874679 490 ClinVar
295500 590 ClinVar
295501 721 ClinVar
295502 748 ClinVar
295503 773 ClinVar
295504 782 ClinVar
295505 789 ClinVar
295506 963 ClinVar
874680 970 ClinVar
875621 973 ClinVar
875622 1035 ClinVar
295507 1129 ClinVar
295508 1199 ClinVar
295509 1224 ClinVar
295510 1224 ClinVar
295511 1230 ClinVar
295512 1234 ClinVar
875623 1272 ClinVar
295513 1274 ClinVar
295514 1311 ClinVar
295515 1316 ClinVar
295516 1339 ClinVar
876621 1390 ClinVar
876622 1429 ClinVar
876623 1432 ClinVar
295517 1444 ClinVar
295518 1503 ClinVar
295519 1586 ClinVar
295520 1616 ClinVar
295521 1625 ClinVar
295522 1685 ClinVar
873770 1872 ClinVar
873771 2008 ClinVar
295523 2009 ClinVar
295524 2054 ClinVar
295525 2090 ClinVar
295526 2109 ClinVar
295527 2189 ClinVar
295528 2270 ClinVar
295529 2348 ClinVar
295530 2348 ClinVar
295531 2348 ClinVar
874726 2353 ClinVar
874727 2422 ClinVar
295532 2432 ClinVar
874728 2497 ClinVar
875666 2510 ClinVar
295533 2565 ClinVar
295534 2618 ClinVar
295535 2840 ClinVar
295536 2951 ClinVar
295537 2981 ClinVar
875667 3077 ClinVar
295538 3142 ClinVar
876662 3194 ClinVar
295539 3197 ClinVar
876663 3211 ClinVar
COSN26998437 15 COSMIC
COSN30115738 24 COSMIC
COSN31536097 31 COSMIC
COSN31586213 37 COSMIC
COSN31555407 52 COSMIC
COSN31556700 57 COSMIC
COSN7203850 60 COSMIC
COSN30118870 66 COSMIC
COSN30115056 67 COSMIC
COSN31567290 68 COSMIC
COSN31580841 119 COSMIC
COSN7985395 122 COSMIC
COSN30115164 123 COSMIC
COSN30493155 124 COSMIC
COSN30505565 135 COSMIC
COSN31522178 260 COSMIC
COSN28643183 299 COSMIC
COSN27405545 800 COSMIC
COSN22372997 828 COSMIC
COSN15081062 880 COSMIC
COSN29983215 995 COSMIC
COSN20583014 1071 COSMIC
COSN24427368 1234 COSMIC
COSN23883777 1310 COSMIC
COSN23719137 1311 COSMIC
COSN7985396 1472 COSMIC
COSN20621830 1613 COSMIC
COSN1431993 1633 COSMIC
COSN8433980 1890 COSMIC
COSN1431994 2145 COSMIC
COSN7203851 2171 COSMIC
COSN7203852 2347 COSMIC
COSN20096020 2361 COSMIC
COSN20096019 2362 COSMIC
COSN18723659 2363 COSMIC
COSN8969993 2479 COSMIC
COSN27017336 2629 COSMIC
COSN1098041 2644 COSMIC
COSN4748082 2700 COSMIC
COSN22870599 2922 COSMIC
COSN1431995 2965 COSMIC
COSN22513511 2976 COSMIC
rs900 202 GWAS
rs991967 748 GWAS
rs6704255 2840 GWAS
rs6683598 3197 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs779799713 3 dbSNP
rs753809089 4 dbSNP
rs1316254054 7 dbSNP
rs754901678 9 dbSNP
rs1057521805 10 dbSNP
rs1437335292 13 dbSNP
rs1057520937 16 dbSNP
rs778452299 22 dbSNP
rs757989824 24 dbSNP
rs1241980032 29 dbSNP
rs921778383 30 dbSNP
rs1286471169 32 dbSNP
rs751861199 33 dbSNP
rs766639397 33 dbSNP
rs777440461 34 dbSNP
rs933027208 35 dbSNP
rs1203026622 36 dbSNP
rs746621591 38 dbSNP
rs770324190 39 dbSNP
rs11466412 40 dbSNP
rs1252906196 41 dbSNP
rs749872228 43 dbSNP
rs755922331 43 dbSNP
rs769232186 46 dbSNP
rs777601980 46 dbSNP
rs1453130484 49 dbSNP
rs1180858363 52 dbSNP
rs1444216858 54 dbSNP
rs1372866415 57 dbSNP
rs772714576 58 dbSNP
rs1013731525 60 dbSNP
rs1427235848 61 dbSNP
rs1333613332 62 dbSNP
rs1309161752 65 dbSNP
rs182677992 66 dbSNP
rs905478872 69 dbSNP
rs1000936851 72 dbSNP
rs1180509132 81 dbSNP
rs1262394311 84 dbSNP
rs1459849263 89 dbSNP
rs1205313450 90 dbSNP
rs1253134155 91 dbSNP
rs1004581737 93 dbSNP
rs748904732 98 dbSNP
rs770520991 99 dbSNP
rs1009289227 107 dbSNP
rs1038340320 111 dbSNP
rs1174999848 123 dbSNP
rs1019391394 133 dbSNP
rs755257151 135 dbSNP
rs61762489 136 dbSNP
rs1176399098 150 dbSNP
rs1225279594 150 dbSNP
rs1329670685 154 dbSNP
rs1427800988 155 dbSNP
rs1471200263 159 dbSNP
rs1346786037 160 dbSNP
rs1293611082 182 dbSNP
rs1435258473 182 dbSNP
rs139161891 185 dbSNP
rs975271085 187 dbSNP
rs1459123810 192 dbSNP
rs1413240885 194 dbSNP
rs1021 195 dbSNP
rs1159053834 195 dbSNP
rs751637464 196 dbSNP
rs900 202 dbSNP
rs1191880390 208 dbSNP
rs149532526 210 dbSNP
rs781729734 211 dbSNP
rs1218261548 227 dbSNP
rs1440230476 230 dbSNP
rs952622720 232 dbSNP
rs1226428581 235 dbSNP
rs1023769478 236 dbSNP
rs1351222789 243 dbSNP
rs1325622713 250 dbSNP
rs1301297401 255 dbSNP
rs532806555 256 dbSNP
rs1282624256 260 dbSNP
rs1364925696 260 dbSNP
rs1321255058 261 dbSNP
rs1225134661 262 dbSNP
rs984454109 263 dbSNP
rs1436900116 268 dbSNP
rs549363492 269 dbSNP
rs201574411 272 dbSNP
rs759292198 281 dbSNP
rs1320317593 285 dbSNP
rs909187506 287 dbSNP
rs1234235799 289 dbSNP
rs769938950 297 dbSNP
rs1379906850 298 dbSNP
rs1483131271 303 dbSNP
rs989533012 304 dbSNP
rs940706893 308 dbSNP
rs187309381 311 dbSNP
rs1423234957 313 dbSNP
rs1021487440 315 dbSNP
rs1036387945 322 dbSNP
rs1228603062 322 dbSNP
rs374364243 322 dbSNP
rs774827669 322 dbSNP
rs775860474 322 dbSNP
rs921747814 322 dbSNP
rs968570202 322 dbSNP
rs918031090 323 dbSNP
rs1364050741 324 dbSNP
rs1173550084 325 dbSNP
rs1433322687 333 dbSNP
rs558875646 338 dbSNP
rs369493144 340 dbSNP
rs1408537577 343 dbSNP
rs201410439 343 dbSNP
rs11118106 344 dbSNP
rs933183165 348 dbSNP
rs1172865103 351 dbSNP
rs905361907 354 dbSNP
rs1430590052 360 dbSNP
rs936902644 370 dbSNP
rs1186948837 373 dbSNP
rs1054458441 377 dbSNP
rs535163561 378 dbSNP
rs548769681 380 dbSNP
rs1301311994 382 dbSNP
rs1019358287 383 dbSNP
rs900954390 392 dbSNP
rs996602722 393 dbSNP
rs535186460 395 dbSNP
rs577176803 396 dbSNP
rs1037407138 422 dbSNP
rs984034253 428 dbSNP
rs1015951460 429 dbSNP
rs1395916394 430 dbSNP
rs1377649301 434 dbSNP
rs1276418980 436 dbSNP
rs898834654 452 dbSNP
rs1430450867 456 dbSNP
rs1166928750 457 dbSNP
rs1459650698 461 dbSNP
rs1342352790 468 dbSNP
rs562434477 471 dbSNP
rs1421938995 472 dbSNP
rs1253863278 478 dbSNP
rs558071814 490 dbSNP
rs1482440554 492 dbSNP
rs1249058567 493 dbSNP
rs1211207865 495 dbSNP
rs1356650347 499 dbSNP
rs775274191 503 dbSNP
rs571562927 504 dbSNP
rs972073852 527 dbSNP
rs1031498908 545 dbSNP
rs892584361 564 dbSNP
rs1411033354 565 dbSNP
rs1349883455 582 dbSNP
rs886045981 590 dbSNP
rs949431729 594 dbSNP
rs146035327 595 dbSNP
rs1293212912 601 dbSNP
rs1413996339 601 dbSNP
rs1456173731 601 dbSNP
rs926782062 602 dbSNP
rs1472232923 604 dbSNP
rs1409044564 609 dbSNP
rs1200399982 613 dbSNP
rs1451723355 615 dbSNP
rs1266191726 616 dbSNP
rs556579816 634 dbSNP
rs1467403014 640 dbSNP
rs1161785806 643 dbSNP
rs1270431049 643 dbSNP
rs1229477147 646 dbSNP
rs1329110229 648 dbSNP
rs954683964 649 dbSNP
rs762017464 655 dbSNP
rs1331798406 656 dbSNP
rs1367572109 666 dbSNP
rs892738512 679 dbSNP
rs987361681 681 dbSNP
rs1320986187 683 dbSNP
rs945013843 684 dbSNP
rs576467914 691 dbSNP
rs1386331903 692 dbSNP
rs900849523 694 dbSNP
rs942272943 699 dbSNP
rs544540486 721 dbSNP
rs192106773 726 dbSNP
rs1196232268 727 dbSNP
rs888268829 730 dbSNP
rs368382861 731 dbSNP
rs1244732861 736 dbSNP
rs973167571 747 dbSNP
rs991967 748 dbSNP
rs1202780358 753 dbSNP
rs1345794189 767 dbSNP
rs1357908482 769 dbSNP
rs1274350690 770 dbSNP
rs947730996 772 dbSNP
rs886045982 773 dbSNP
rs1298669423 777 dbSNP
rs886045983 782 dbSNP
rs541258443 785 dbSNP
rs564487575 786 dbSNP
rs1233927096 789 dbSNP
rs1324535785 789 dbSNP
rs1336075815 789 dbSNP
rs1400786043 789 dbSNP
rs57430619 789 dbSNP
rs1170327814 797 dbSNP
rs1209897852 801 dbSNP
rs1284258224 807 dbSNP
rs1445710107 808 dbSNP
rs1218414024 811 dbSNP
rs1248993401 817 dbSNP
rs961316051 821 dbSNP
rs1390383015 828 dbSNP
rs140010266 833 dbSNP
rs1024897677 835 dbSNP
rs939505294 839 dbSNP
rs1240782466 843 dbSNP
rs1190151611 847 dbSNP
rs1443502452 857 dbSNP
rs183485193 858 dbSNP
rs1277955583 862 dbSNP
rs1208849453 865 dbSNP
rs970715133 866 dbSNP
rs980798074 868 dbSNP
rs1228017950 872 dbSNP
rs1359531089 876 dbSNP
rs1285733491 884 dbSNP
rs562961874 885 dbSNP
rs892629012 888 dbSNP
rs1311047664 890 dbSNP
rs1473207292 895 dbSNP
rs1411099159 901 dbSNP
rs926722049 903 dbSNP
rs750470386 904 dbSNP
rs1427438055 905 dbSNP
rs1010924389 907 dbSNP
rs1165397062 908 dbSNP
rs1043805251 914 dbSNP
rs1158002583 919 dbSNP
rs1384181880 925 dbSNP
rs1398827836 926 dbSNP
rs528835468 929 dbSNP
rs1322332077 930 dbSNP
rs899833579 937 dbSNP
rs914154165 949 dbSNP
rs996827065 955 dbSNP
rs1252642310 958 dbSNP
rs886045984 963 dbSNP
rs187495965 970 dbSNP
rs371382507 972 dbSNP
rs565195408 973 dbSNP
rs1291695764 989 dbSNP
rs79980454 994 dbSNP
rs1312537835 1000 dbSNP
rs922240441 1008 dbSNP
rs1291362107 1012 dbSNP
rs954685259 1025 dbSNP
rs1341888302 1028 dbSNP
rs1350510931 1031 dbSNP
rs932331054 1035 dbSNP
rs1439521180 1037 dbSNP
rs528335047 1053 dbSNP
rs551263488 1055 dbSNP
rs888228539 1057 dbSNP
rs571597357 1060 dbSNP
rs1014735342 1064 dbSNP
rs191862791 1068 dbSNP
rs1005381842 1074 dbSNP
rs1406314087 1075 dbSNP
rs1417665985 1076 dbSNP
rs1037233236 1083 dbSNP
rs1473858413 1086 dbSNP
rs1412744248 1090 dbSNP
rs527556492 1098 dbSNP
rs1479725673 1099 dbSNP
rs796089981 1104 dbSNP
rs1222678236 1118 dbSNP
rs1024194058 1119 dbSNP
rs970682747 1123 dbSNP
rs56271792 1129 dbSNP
rs752019003 1132 dbSNP
rs1287108804 1145 dbSNP
rs1221553988 1147 dbSNP
rs374661174 1151 dbSNP
rs958399570 1162 dbSNP
rs989580536 1164 dbSNP
rs1461195483 1172 dbSNP
rs1275059828 1174 dbSNP
rs755382154 1175 dbSNP
rs1202169223 1179 dbSNP
rs1002614578 1180 dbSNP
rs939578272 1181 dbSNP
rs966887555 1185 dbSNP
rs976986070 1186 dbSNP
rs922878902 1191 dbSNP
rs879100557 1193 dbSNP
rs556560548 1199 dbSNP
rs1427429622 1210 dbSNP
rs1049900867 1211 dbSNP
rs1362091029 1213 dbSNP
rs1454001532 1220 dbSNP
rs1250864998 1221 dbSNP
rs532376886 1224 dbSNP
rs532935567 1224 dbSNP
rs551430704 1224 dbSNP
rs886045985 1224 dbSNP
rs886045986 1224 dbSNP
rs1213623925 1227 dbSNP
rs1313381032 1229 dbSNP
rs781757001 1230 dbSNP
rs555872587 1234 dbSNP
rs1412604799 1237 dbSNP
rs1368356959 1239 dbSNP
rs1036795820 1246 dbSNP
rs1437681673 1251 dbSNP
rs896968238 1263 dbSNP
rs572446864 1272 dbSNP
rs143593418 1274 dbSNP
rs905820283 1282 dbSNP
rs1002205110 1287 dbSNP
rs1008785075 1288 dbSNP
rs1034055517 1289 dbSNP
rs1360903200 1292 dbSNP
rs1403919480 1295 dbSNP
rs1396212776 1300 dbSNP
rs529265174 1304 dbSNP
rs199500374 1306 dbSNP
rs761845506 1306 dbSNP
rs772780936 1306 dbSNP
rs1333530520 1309 dbSNP
rs201094302 1310 dbSNP
rs1418556 1311 dbSNP
rs961884387 1311 dbSNP
rs1237503805 1314 dbSNP
rs577782618 1316 dbSNP
rs1345168012 1317 dbSNP
rs891626252 1320 dbSNP
rs1222085570 1324 dbSNP
rs1258087209 1325 dbSNP
rs1346012541 1332 dbSNP
rs1343247796 1334 dbSNP
rs969090344 1337 dbSNP
rs574858097 1339 dbSNP
rs1303986205 1341 dbSNP
rs1484108430 1342 dbSNP
rs966856519 1344 dbSNP
rs182607525 1358 dbSNP
rs1252458320 1368 dbSNP
rs1480035617 1380 dbSNP
rs1173719466 1381 dbSNP
rs146805202 1382 dbSNP
rs528922293 1390 dbSNP
rs187035758 1399 dbSNP
rs549505330 1405 dbSNP
rs373191185 1407 dbSNP
rs569227623 1414 dbSNP
rs1308057092 1420 dbSNP
rs1251063378 1422 dbSNP
rs770610828 1429 dbSNP
rs909509448 1435 dbSNP
rs1403592175 1437 dbSNP
rs941055271 1442 dbSNP
rs60086269 1444 dbSNP
rs528156663 1456 dbSNP
rs545701100 1464 dbSNP
rs745717964 1466 dbSNP
rs1309967463 1467 dbSNP
rs1410609723 1473 dbSNP
rs1227131209 1483 dbSNP
rs1296707048 1484 dbSNP
rs1051628141 1494 dbSNP
rs1368893861 1497 dbSNP
rs949877348 1500 dbSNP
rs1474188377 1501 dbSNP
rs17500758 1503 dbSNP
rs1344503573 1506 dbSNP
rs1205971726 1510 dbSNP
rs1036279300 1513 dbSNP
rs571628370 1527 dbSNP
rs148532364 1529 dbSNP
rs937220134 1530 dbSNP
rs1054399885 1531 dbSNP
rs1274200938 1544 dbSNP
rs1213567539 1546 dbSNP
rs1333360224 1562 dbSNP
rs994762187 1565 dbSNP
rs1027448910 1575 dbSNP
rs550905009 1578 dbSNP
rs1269361468 1580 dbSNP
rs775286230 1581 dbSNP
rs905044567 1582 dbSNP
rs17047863 1586 dbSNP
rs535892390 1587 dbSNP
rs1391099778 1588 dbSNP
rs1010938290 1598 dbSNP
rs1387956180 1611 dbSNP
rs886045987 1616 dbSNP
rs3737977 1625 dbSNP
rs773208179 1626 dbSNP
rs988254388 1644 dbSNP
rs902639406 1645 dbSNP
rs566199229 1646 dbSNP
rs1159872954 1647 dbSNP
rs1469180798 1649 dbSNP
rs1422188498 1650 dbSNP
rs998274924 1657 dbSNP
rs1021199003 1658 dbSNP
rs1200463930 1659 dbSNP
rs1029803435 1660 dbSNP
rs1368906486 1671 dbSNP
rs1193373415 1673 dbSNP
rs1467447384 1673 dbSNP
rs1270570992 1674 dbSNP
rs1206298801 1676 dbSNP
rs968237353 1677 dbSNP
rs192396801 1685 dbSNP
rs1235645173 1686 dbSNP
rs921409704 1688 dbSNP
rs1303012867 1689 dbSNP
rs1438407474 1692 dbSNP
rs1367184162 1700 dbSNP
rs986091987 1704 dbSNP
rs557802645 1708 dbSNP
rs1382090036 1712 dbSNP
rs932848583 1716 dbSNP
rs1367646730 1719 dbSNP
rs1466144606 1722 dbSNP
rs1017209621 1723 dbSNP
rs1229359547 1731 dbSNP
rs1452947577 1739 dbSNP
rs34039370 1748 dbSNP
rs577824126 1757 dbSNP
rs972405302 1758 dbSNP
rs537236815 1760 dbSNP
rs557278950 1763 dbSNP
rs949764042 1765 dbSNP
rs1202226637 1773 dbSNP
rs1037404269 1775 dbSNP
rs1279879839 1777 dbSNP
rs1232445204 1778 dbSNP
rs898500089 1781 dbSNP
rs1270580684 1782 dbSNP
rs1429876723 1788 dbSNP
rs574229434 1788 dbSNP
rs1488736179 1789 dbSNP
rs981162536 1791 dbSNP
rs1245924020 1795 dbSNP
rs927097576 1801 dbSNP
rs1374381355 1802 dbSNP
rs937215055 1804 dbSNP
rs542639949 1806 dbSNP
rs1168879706 1819 dbSNP
rs1384202046 1829 dbSNP
rs896258973 1833 dbSNP
rs1371815074 1836 dbSNP
rs559099734 1850 dbSNP
rs1190305718 1853 dbSNP
rs1421609626 1858 dbSNP
rs1486034904 1859 dbSNP
rs1256918688 1863 dbSNP
rs1208921277 1869 dbSNP
rs1009327040 1872 dbSNP
rs893088837 1880 dbSNP
rs1350988804 1882 dbSNP
rs1337278376 1901 dbSNP
rs1285867403 1906 dbSNP
rs1233836430 1908 dbSNP
rs572768123 1917 dbSNP
rs946705793 1920 dbSNP
rs759571165 1921 dbSNP
rs1318997970 1926 dbSNP
rs545126491 1927 dbSNP
rs1354730991 1931 dbSNP
rs878968888 1934 dbSNP
rs751827445 1936 dbSNP
rs998242446 1941 dbSNP
rs1409748186 1948 dbSNP
rs979639754 1952 dbSNP
rs1029769341 1974 dbSNP
rs1475824823 1981 dbSNP
rs1391351427 1984 dbSNP
rs1185868064 1989 dbSNP
rs1473634479 1993 dbSNP
rs889932472 1999 dbSNP
rs1007087694 2008 dbSNP
rs12408711 2009 dbSNP
rs963030219 2021 dbSNP
rs1291765703 2022 dbSNP
rs994379558 2025 dbSNP
rs1025228498 2033 dbSNP
rs1334099113 2036 dbSNP
rs912735959 2037 dbSNP
rs1229665413 2038 dbSNP
rs1373515487 2039 dbSNP
rs1278580773 2042 dbSNP
rs971049391 2051 dbSNP
rs530767727 2054 dbSNP
rs371822225 2061 dbSNP
rs1328387573 2071 dbSNP
rs927093986 2076 dbSNP
rs958779793 2078 dbSNP
rs990040001 2080 dbSNP
rs1163480276 2086 dbSNP
rs1402506170 2088 dbSNP
rs886045988 2090 dbSNP
rs1238296257 2101 dbSNP
rs1048991112 2103 dbSNP
rs184256338 2109 dbSNP
rs561266213 2111 dbSNP
rs1248189335 2117 dbSNP
rs945913675 2127 dbSNP
rs756607110 2130 dbSNP
rs1041670055 2137 dbSNP
rs1194009036 2140 dbSNP
rs937854520 2141 dbSNP
rs1056667799 2154 dbSNP
rs1210582210 2158 dbSNP
rs1209113061 2162 dbSNP
rs896323839 2171 dbSNP
rs1221679655 2179 dbSNP
rs1009708558 2181 dbSNP
rs1303740344 2183 dbSNP
rs1442089565 2188 dbSNP
rs17047869 2189 dbSNP
rs934002606 2192 dbSNP
rs1482037125 2198 dbSNP
rs1183118961 2202 dbSNP
rs753394620 2207 dbSNP
rs1345820033 2208 dbSNP
rs1417967961 2212 dbSNP
rs1157664282 2215 dbSNP
rs1397087228 2219 dbSNP
rs903509703 2223 dbSNP
rs1250927828 2225 dbSNP
rs1000525997 2243 dbSNP
rs546838652 2248 dbSNP
rs190417771 2252 dbSNP
rs1458100427 2257 dbSNP
rs1336424419 2266 dbSNP
rs193244018 2270 dbSNP
rs1038496271 2271 dbSNP
rs756746142 2278 dbSNP
rs1233122460 2285 dbSNP
rs898666602 2286 dbSNP
rs551500171 2287 dbSNP
rs994348581 2296 dbSNP
rs1301739066 2304 dbSNP
rs1008480582 2308 dbSNP
rs1020175636 2317 dbSNP
rs376837920 2322 dbSNP
rs571402381 2327 dbSNP
rs1428718142 2330 dbSNP
rs1377416111 2339 dbSNP
rs1025878356 2346 dbSNP
rs1313656124 2348 dbSNP
rs3054943 2348 dbSNP
rs71852018 2348 dbSNP
rs773405899 2348 dbSNP
rs781581340 2348 dbSNP
rs869143666 2348 dbSNP
rs886045989 2348 dbSNP
rs886045990 2348 dbSNP
rs886045991 2348 dbSNP
rs1418696683 2352 dbSNP
rs537275941 2353 dbSNP
rs1486332264 2354 dbSNP
rs1002530949 2357 dbSNP
rs1491073945 2361 dbSNP
rs1276395486 2362 dbSNP
rs1484498562 2362 dbSNP
rs199581711 2362 dbSNP
rs1286446939 2363 dbSNP
rs1348062244 2364 dbSNP
rs1331041969 2367 dbSNP
rs1228792340 2368 dbSNP
rs972799024 2370 dbSNP
rs1294019988 2372 dbSNP
rs557117464 2372 dbSNP
rs1414350474 2373 dbSNP
rs1373849417 2390 dbSNP
rs1310103375 2393 dbSNP
rs367859892 2397 dbSNP
rs1211847994 2415 dbSNP
rs920033638 2416 dbSNP
rs1168147674 2418 dbSNP
rs1417886410 2419 dbSNP
rs1186577501 2424 dbSNP
rs1046017 2432 dbSNP
rs184498462 2435 dbSNP
rs980135372 2441 dbSNP
rs1179304739 2442 dbSNP
rs1481131969 2447 dbSNP
rs1254612692 2449 dbSNP
rs1473179298 2450 dbSNP
rs1337616809 2452 dbSNP
rs1274408699 2454 dbSNP
rs1232742390 2455 dbSNP
rs927289397 2457 dbSNP
rs1034513686 2462 dbSNP
rs958443804 2471 dbSNP
rs1176204600 2482 dbSNP
rs1372291699 2491 dbSNP
rs1216626209 2496 dbSNP
rs745522168 2497 dbSNP
rs914383841 2498 dbSNP
rs553582603 2505 dbSNP
rs1164209479 2506 dbSNP
rs1056402603 2507 dbSNP
rs545013272 2508 dbSNP
rs967223935 2510 dbSNP
rs1182002582 2512 dbSNP
rs567856666 2517 dbSNP
rs1250199756 2518 dbSNP
rs556257908 2520 dbSNP
rs977318048 2523 dbSNP
rs1470144310 2526 dbSNP
rs141051262 2530 dbSNP
rs1213627662 2536 dbSNP
rs1354152019 2537 dbSNP
rs879908227 2542 dbSNP
rs771709467 2562 dbSNP
rs77808075 2565 dbSNP
rs1042117600 2566 dbSNP
rs377003546 2568 dbSNP
rs1309862887 2570 dbSNP
rs903644007 2571 dbSNP
rs544454418 2581 dbSNP
rs560941923 2582 dbSNP
rs1274145531 2587 dbSNP
rs1008867468 2591 dbSNP
rs1386446328 2593 dbSNP
rs1019893384 2607 dbSNP
rs942764068 2611 dbSNP
rs1361678037 2613 dbSNP
rs886045992 2618 dbSNP
rs994377706 2623 dbSNP
rs1455809205 2624 dbSNP
rs1038873114 2628 dbSNP
rs746790035 2629 dbSNP
rs1202437150 2632 dbSNP
rs369664926 2633 dbSNP
rs994325832 2641 dbSNP
rs867349027 2643 dbSNP
rs1264538682 2645 dbSNP
rs1047296859 2664 dbSNP
rs1034742268 2669 dbSNP
rs1483080778 2677 dbSNP
rs546581619 2680 dbSNP
rs1199394115 2684 dbSNP
rs992473105 2687 dbSNP
rs1245468376 2698 dbSNP
rs917879051 2699 dbSNP
rs1230917762 2700 dbSNP
rs1328108808 2701 dbSNP
rs1318945226 2702 dbSNP
rs1381161356 2704 dbSNP
rs560385544 2727 dbSNP
rs1314251270 2729 dbSNP
rs1003084085 2731 dbSNP
rs768524820 2733 dbSNP
rs977858238 2734 dbSNP
rs1033986309 2739 dbSNP
rs894147558 2741 dbSNP
rs188856339 2750 dbSNP
rs1011302733 2751 dbSNP
rs1446444567 2753 dbSNP
rs1261132772 2757 dbSNP
rs889945494 2759 dbSNP
rs1419084890 2763 dbSNP
rs1279946036 2764 dbSNP
rs1198487509 2768 dbSNP
rs1049481611 2769 dbSNP
rs1021815131 2770 dbSNP
rs889436327 2775 dbSNP
rs1226607286 2780 dbSNP
rs1337715462 2793 dbSNP
rs1170598425 2799 dbSNP
rs967189805 2808 dbSNP
rs977286731 2820 dbSNP
rs375956187 2821 dbSNP
rs954569290 2824 dbSNP
rs986458840 2830 dbSNP
rs1371285807 2831 dbSNP
rs1414918351 2832 dbSNP
rs1374443021 2838 dbSNP
rs150263246 2839 dbSNP
rs6704255 2840 dbSNP
rs1399098263 2845 dbSNP
rs571440594 2851 dbSNP
rs1322888391 2853 dbSNP
rs920045639 2870 dbSNP
rs530925294 2884 dbSNP
rs1027115811 2899 dbSNP
rs1475601671 2910 dbSNP
rs888638322 2911 dbSNP
rs1439268261 2912 dbSNP
rs1273481233 2914 dbSNP
rs1195103343 2915 dbSNP
rs1275015999 2916 dbSNP
rs1438364456 2916 dbSNP
rs930144355 2918 dbSNP
rs1233358407 2925 dbSNP
rs1354335821 2926 dbSNP
rs1275171581 2934 dbSNP
rs1001592818 2938 dbSNP
rs1274482521 2940 dbSNP
rs1443930140 2946 dbSNP
rs147957308 2951 dbSNP
rs1299335173 2952 dbSNP
rs1329998441 2958 dbSNP
rs1465480155 2959 dbSNP
rs1398702065 2961 dbSNP
rs1468497259 2964 dbSNP
rs749449913 2976 dbSNP
rs1208718684 2977 dbSNP
rs1020709619 2978 dbSNP
rs780318084 2980 dbSNP
rs886045993 2981 dbSNP
rs1233712518 2989 dbSNP
rs1180782930 3004 dbSNP
rs796095184 3008 dbSNP
rs1056469623 3009 dbSNP
rs567759443 3017 dbSNP
rs1456326943 3020 dbSNP
rs1254800151 3022 dbSNP
rs894124230 3027 dbSNP
rs966558165 3039 dbSNP
rs1333435631 3040 dbSNP
rs977996878 3051 dbSNP
rs536810691 3054 dbSNP
rs1225065949 3059 dbSNP
rs1011687111 3060 dbSNP
rs1453771675 3066 dbSNP
rs565027084 3067 dbSNP
rs1375225624 3076 dbSNP
rs1328452670 3081 dbSNP
rs1442318017 3087 dbSNP
rs902974236 3092 dbSNP
rs1162739881 3101 dbSNP
rs998607188 3119 dbSNP
rs1030133388 3125 dbSNP
rs1158331124 3130 dbSNP
rs1437527950 3133 dbSNP
rs886045994 3142 dbSNP
rs985594116 3145 dbSNP
rs771142078 3149 dbSNP
rs879858632 3152 dbSNP
rs553432793 3153 dbSNP
rs1467996564 3154 dbSNP
rs1190804608 3155 dbSNP
rs774517988 3162 dbSNP
rs1217273573 3165 dbSNP
rs1447145299 3166 dbSNP
rs1444089903 3167 dbSNP
rs1237532318 3177 dbSNP
rs943695602 3178 dbSNP
rs1306108570 3179 dbSNP
rs1040680087 3181 dbSNP
rs896828458 3182 dbSNP
rs1292359144 3184 dbSNP
rs558156289 3184 dbSNP
rs930191140 3186 dbSNP
rs1297749041 3190 dbSNP
rs1161476569 3194 dbSNP
rs6683598 3197 dbSNP
rs1174007997 3198 dbSNP
rs541359760 3204 dbSNP
rs1406979040 3205 dbSNP
rs964072310 3208 dbSNP
rs1324095546 3210 dbSNP
rs767736529 3211 dbSNP
rs1241026387 3214 dbSNP
rs1034838603 3215 dbSNP
rs974521769 3216 dbSNP
rs1432624489 3228 dbSNP
rs919932604 3229 dbSNP
rs1014755249 3236 dbSNP
rs1322207782 3236 dbSNP
rs1216833375 3239 dbSNP
rs538668983 3241 dbSNP
rs544476957 3243 dbSNP
rs967364171 3244 dbSNP
rs999385689 3256 dbSNP
rs1281870765 3257 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaagaccgaggUUCAGguca 5'
                     |||||    
Target 5' aaaggggaaaaAAGUC---- 3'
 		2 - 17
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_003238 | 3UTR | UCCAGGUCAGCAUAAGUCAUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000366930.4 | 3UTR | AAAAGGGGAAAAAAGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
27 hsa-miR-378f Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT463100 ZNF609 zinc finger protein 609 2 2
MIRT469371 REST RE1 silencing transcription factor 2 6
MIRT495441 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT513606 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT520414 TXNL1 thioredoxin like 1 2 4
MIRT525111 PRKD2 protein kinase D2 2 2
MIRT525979 SPA17 sperm autoantigenic protein 17 2 2
MIRT527002 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT529215 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT529835 ARGFX arginine-fifty homeobox 2 2
MIRT532300 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT537577 ESYT2 extended synaptotagmin 2 2 2
MIRT543140 AKT1 AKT serine/threonine kinase 1 2 2
MIRT554924 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT564970 WTAP WT1 associated protein 2 2
MIRT570115 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT652734 TGFB2 transforming growth factor beta 2 2 2
MIRT655948 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT655997 MYRF myelin regulatory factor 2 2
MIRT684875 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT692969 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693737 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT710991 PPARGC1B PPARG coactivator 1 beta 2 2
MIRT712247 RCC2 regulator of chromosome condensation 2 2 2
MIRT718602 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT723499 WDR33 WD repeat domain 33 2 2
MIRT725448 HIPK3 homeodomain interacting protein kinase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-378f Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-378f Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-mir-378f Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)

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