miRTarBase - #MIRT652812


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pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol TBL2   
Synonyms WBSCR13, WS-betaTRP
Description transducin beta like 2
Transcript NM_012453   
Expression
Putative miRNA Targets on TBL2
3'UTR of TBL2
(miRNA target sites are highlighted)		 
>TBL2|NM_012453|3'UTR
   1 CTCTGGGAGGGCCCGGCGCAGAGGATTGAGGAGGAGGGATCTGGCCTCCTCATGGCACTGCTGCCATCTTTCCTCCCAGG
  81 TGGAAGCCTTTCAGAAGGAGTCTCCTGGTTTTCTTACTGGTGGCCCTGCTTCTTCCCATTGAAACTACTCTTGTCTACTT
 161 AGGTCTCTCTCTTCTTGCTGGCTGTGACTCCTCCCTGACTAGTGGCCAAGGTGCTTTTCTTCCTCCCAGGCCCAGTGGGT
 241 GGAATCTGTCCCCACCTGGCACTGAGGAGAATGGTAGAGAGGAGAGGAGAGAGAGAGAGAATGTGATTTTTGGCCTTGTG
 321 GCAGCACATCCTCACACCCAAAGAAGTTTGTAAATGTTCCAGAACAACCTAGAGAACACCTGAGTACTAAGCAGCAGTTT
 401 TGCAAGGATGGGAGACTGGGATAGCTTCCCATCACAGAACTGTGTTCCATCAAAAAGACACTAAGGGATTTCCTTCTGGG
 481 CCTCAGTTCTATTTGTAAGATGGAGAATAATCCTCTCTGTGAACTCCTTGCAAAGATGATATGAGGCTAAGAGAATATCA
 561 AGTCCCCAGGTCTGGAAGAAAAGTAGAAAAGAGTAGTACTATTGTCCAATGTCATGAAAGTGGTAAAAGTGGGAACCAGT
 641 GTGCTTTGAAACCAAATTAGAAACACATTCCTTGGGAAGGCAAAGTTTTCTGGGACTTGATCATACATTTTATATGGTTG
 721 GGACTTCTCTCTTCGGGAGATGATATCTTGTTTAAGGAGACCTCTTTTCAGTTCATCAAGTTCATCAGATATTTGAGTGC
 801 CCACTCTGTGCCCAAATAAATATGAGCTGGGGATTAAATACGAATAAGACATGGTTTCTGCCATCAAAGATGGCTGGTGG
 881 GAGAGAGAGATACACCCTTATTAAGTGCTTTGTGTTAGTTTATTCATAGCTATTGTTATATATGTCAAGGCAAGAGAGGA
 961 CCAGAGCAGGACAGAGGCAATGGGTATTGAAGTTGAAGGGGTACATTTGATAAGAGAGTCGGTATTGAGAAGTTTAAATT
1041 TGTGAATTTGAAGGCTGCGTGGGTGTGGCAGGTAAGGGAAATGAGGTATCTGGGAAGGCTTGAGTGTAGGCAAATTTATT
1121 CATCCCAAGTCAAACTCTTGATCTCTCTCACGAAAACTATGACCCCCCCTGGTTGCCCCTGACCTCTCAATGTTGGAACA
1201 AGCCACAACCGTGGAGTTATCCTTGATGACTCCCCATTCATTATCCCTTCTGTCCCACCACCACAGCTGTCATCTGTTCA
1281 CCAGAACGTTCTTTTGGTTACACTCCATGTGACATCCTGAGGCTGTTGCTTCTCTCCAGCTTTTCTGTTACCATCCTGGT
1361 CCTGGCTACTGTCACCTAGTGGGCCACTATAATATGGCTTCCTAATGGATCTTCCTGCTTCCTCTGTTGCCTCATTACTT
1441 TTCTATATAGCAGAATGATCTTTTGAAAATGTGAACCAGATCACATTATTCCCTAGTTAAAACCCCCCAAGGCTTCCCAT
1521 CACACTTGGAATAAAATCCAAAAGAATTTTTCTAAACCAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaUAC---CCACCCUGUCUCUCcc 5'
            |||   ||||||| ||||||  
Target 5' agATGGCTGGTGGGAGAGAGAGat 3'
 868 - 891 155.00 -23.40
2 
miRNA  3' gauAC-CCAC--CCUGUCUCUCCc 5'
             || || |   |::||||||| 
Target 5' cacTGAGGAGAATGGTAGAGAGGa 3'
 260 - 283 148.00 -17.70
3 
miRNA  3' gaUACCCACCCUGUCUCUCCc 5'
            |||    ||  ||||||| 
Target 5' atATGTCAAGGCAAGAGAGGa 3'
 940 - 960 147.00 -13.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30678708 18 COSMIC
COSN28189411 36 COSMIC
COSN28662996 57 COSMIC
COSN8517614 79 COSMIC
COSN6891284 239 COSMIC
COSN26700916 270 COSMIC
COSN15819589 330 COSMIC
COSN15662554 537 COSMIC
COSN21795739 952 COSMIC
COSN17489569 1073 COSMIC
rs17145738 1963 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1327452618 1 dbSNP
rs573324682 3 dbSNP
rs782067261 14 dbSNP
rs557976436 15 dbSNP
rs782741124 17 dbSNP
rs546142792 18 dbSNP
rs782564455 22 dbSNP
rs781998930 24 dbSNP
rs782396799 25 dbSNP
rs1339903442 28 dbSNP
rs186492513 36 dbSNP
rs781796941 36 dbSNP
rs782183438 43 dbSNP
rs1200257005 44 dbSNP
rs556409016 46 dbSNP
rs782351676 48 dbSNP
rs868912788 49 dbSNP
rs1373803582 52 dbSNP
rs1461802659 56 dbSNP
rs14415 57 dbSNP
rs782633940 59 dbSNP
rs782524948 60 dbSNP
rs782275839 63 dbSNP
rs1406150942 65 dbSNP
rs1303047591 66 dbSNP
rs1344396556 69 dbSNP
rs911691170 70 dbSNP
rs531093095 76 dbSNP
rs1297288289 77 dbSNP
rs575232188 80 dbSNP
rs1326580671 98 dbSNP
rs567122347 129 dbSNP
rs555096251 130 dbSNP
rs1272148763 132 dbSNP
rs782208570 135 dbSNP
rs987711411 150 dbSNP
rs561863729 151 dbSNP
rs1223188663 152 dbSNP
rs1290937303 155 dbSNP
rs1487578957 167 dbSNP
rs1188288612 169 dbSNP
rs782378425 183 dbSNP
rs1428091658 190 dbSNP
rs1186888040 195 dbSNP
rs1387521720 205 dbSNP
rs1425686967 206 dbSNP
rs1163575618 207 dbSNP
rs989484150 208 dbSNP
rs1348594279 214 dbSNP
rs1455935753 219 dbSNP
rs1290072978 225 dbSNP
rs868951584 233 dbSNP
rs958318927 234 dbSNP
rs1381349717 239 dbSNP
rs1294905903 257 dbSNP
rs1384804472 265 dbSNP
rs1246421004 267 dbSNP
rs1314300985 269 dbSNP
rs781801649 288 dbSNP
rs1218066528 291 dbSNP
rs1261438054 295 dbSNP
rs782297831 299 dbSNP
rs1207139240 301 dbSNP
rs144053241 301 dbSNP
rs1245188963 307 dbSNP
rs782668054 318 dbSNP
rs1412301233 327 dbSNP
rs34496539 333 dbSNP
rs970971926 338 dbSNP
rs1421344217 341 dbSNP
rs1160434911 350 dbSNP
rs1363917410 356 dbSNP
rs1456242524 364 dbSNP
rs1318201985 365 dbSNP
rs1407769817 367 dbSNP
rs1453146584 368 dbSNP
rs1025125847 385 dbSNP
rs1004804107 395 dbSNP
rs1376673628 404 dbSNP
rs143988787 406 dbSNP
rs1026509421 420 dbSNP
rs1316474446 431 dbSNP
rs1226592585 447 dbSNP
rs1265240706 462 dbSNP
rs994508748 466 dbSNP
rs898867279 471 dbSNP
rs1038682162 484 dbSNP
rs1203452812 486 dbSNP
rs1236134652 501 dbSNP
rs1481803544 508 dbSNP
rs1178353720 517 dbSNP
rs1407875427 523 dbSNP
rs753278124 528 dbSNP
rs1471985772 529 dbSNP
rs17341242 537 dbSNP
rs1431005427 539 dbSNP
rs890389432 542 dbSNP
rs1174880154 543 dbSNP
rs782187345 548 dbSNP
rs1444096837 550 dbSNP
rs1298697575 559 dbSNP
rs945231682 565 dbSNP
rs913987349 578 dbSNP
rs1408109768 589 dbSNP
rs990005511 591 dbSNP
rs551212430 595 dbSNP
rs1285213479 598 dbSNP
rs1324344776 599 dbSNP
rs1223171393 609 dbSNP
rs2573 617 dbSNP
rs1309689708 620 dbSNP
rs782468965 621 dbSNP
rs1232813354 629 dbSNP
rs1482332748 631 dbSNP
rs113390078 636 dbSNP
rs970942158 648 dbSNP
rs764923365 652 dbSNP
rs1480476624 660 dbSNP
rs1190332189 663 dbSNP
rs35549119 664 dbSNP
rs1422552814 667 dbSNP
rs1025679852 682 dbSNP
rs1411457967 683 dbSNP
rs982954749 692 dbSNP
rs1170836848 694 dbSNP
rs951669260 696 dbSNP
rs1369893996 702 dbSNP
rs1026054178 704 dbSNP
rs1304841344 706 dbSNP
rs994958956 722 dbSNP
rs782634148 728 dbSNP
rs1435828646 729 dbSNP
rs761412925 734 dbSNP
rs1364266116 735 dbSNP
rs1017198650 736 dbSNP
rs1007192157 737 dbSNP
rs1340442928 740 dbSNP
rs890358472 740 dbSNP
rs551283764 741 dbSNP
rs1225454215 744 dbSNP
rs868989687 745 dbSNP
rs1293126540 746 dbSNP
rs190154596 748 dbSNP
rs2079480 750 dbSNP
rs139412281 752 dbSNP
rs1244655744 756 dbSNP
rs547175087 757 dbSNP
rs75319723 761 dbSNP
rs1186716842 775 dbSNP
rs564574898 775 dbSNP
rs1389365485 779 dbSNP
rs892261249 784 dbSNP
rs1165455941 795 dbSNP
rs1447426350 795 dbSNP
rs546007185 815 dbSNP
rs1321626936 832 dbSNP
rs1347018685 841 dbSNP
rs1431801687 842 dbSNP
rs1297140163 844 dbSNP
rs1363538915 854 dbSNP
rs1248553120 860 dbSNP
rs1316359970 865 dbSNP
rs936717458 873 dbSNP
rs1208750910 891 dbSNP
rs1356219893 891 dbSNP
rs185121856 891 dbSNP
rs1448186448 893 dbSNP
rs782528634 895 dbSNP
rs563580296 896 dbSNP
rs1247014749 898 dbSNP
rs781801677 901 dbSNP
rs1185129424 904 dbSNP
rs1385820739 908 dbSNP
rs151315712 918 dbSNP
rs1472455539 926 dbSNP
rs980756719 935 dbSNP
rs2079481 945 dbSNP
rs1410344174 950 dbSNP
rs1401347142 960 dbSNP
rs1320160043 962 dbSNP
rs35393959 965 dbSNP
rs1386646193 973 dbSNP
rs782695692 982 dbSNP
rs1454948797 983 dbSNP
rs949390609 993 dbSNP
rs2079482 994 dbSNP
rs1340221057 999 dbSNP
rs1243298236 1000 dbSNP
rs1281776295 1001 dbSNP
rs1352287135 1004 dbSNP
rs1228409103 1014 dbSNP
rs1267106102 1020 dbSNP
rs918175617 1025 dbSNP
rs1463237302 1035 dbSNP
rs983471450 1056 dbSNP
rs782098147 1058 dbSNP
rs1256644829 1064 dbSNP
rs183265339 1073 dbSNP
rs1441629872 1074 dbSNP
rs1185406266 1086 dbSNP
rs1234479782 1087 dbSNP
rs920047986 1096 dbSNP
rs1470557598 1100 dbSNP
rs1158473096 1102 dbSNP
rs541824646 1104 dbSNP
rs1410066784 1105 dbSNP
rs1471109240 1106 dbSNP
rs1177373950 1107 dbSNP
rs1402021288 1111 dbSNP
rs1394636442 1113 dbSNP
rs1331471663 1114 dbSNP
rs776370712 1121 dbSNP
rs781819216 1135 dbSNP
rs963070094 1136 dbSNP
rs1409936139 1149 dbSNP
rs1017337573 1151 dbSNP
rs1326425192 1152 dbSNP
rs763901850 1156 dbSNP
rs1256211514 1159 dbSNP
rs1344052557 1163 dbSNP
rs954412142 1164 dbSNP
rs573559042 1168 dbSNP
rs1483316189 1169 dbSNP
rs1181340514 1170 dbSNP
rs1249760960 1170 dbSNP
rs1481455312 1171 dbSNP
rs1030006651 1179 dbSNP
rs886795 1181 dbSNP
rs1377222583 1183 dbSNP
rs1464860772 1183 dbSNP
rs1169965604 1184 dbSNP
rs892401049 1188 dbSNP
rs1053999648 1190 dbSNP
rs1000728026 1191 dbSNP
rs186037340 1199 dbSNP
rs1429725013 1210 dbSNP
rs905257803 1211 dbSNP
rs1348150505 1217 dbSNP
rs1406185827 1220 dbSNP
rs1301550240 1221 dbSNP
rs1330112265 1222 dbSNP
rs1230824557 1225 dbSNP
rs1252908084 1228 dbSNP
rs1342574413 1235 dbSNP
rs1204426028 1243 dbSNP
rs1272367843 1249 dbSNP
rs1490863948 1250 dbSNP
rs1045210510 1254 dbSNP
rs949359511 1259 dbSNP
rs917878448 1267 dbSNP
rs1431605980 1268 dbSNP
rs1391211654 1276 dbSNP
rs1047062224 1287 dbSNP
rs1167282005 1295 dbSNP
rs1367935080 1302 dbSNP
rs142412997 1303 dbSNP
rs1293556032 1308 dbSNP
rs1389364741 1314 dbSNP
rs1384763036 1323 dbSNP
rs1297264478 1326 dbSNP
rs920204547 1328 dbSNP
rs181933287 1336 dbSNP
rs1227318527 1356 dbSNP
rs1295316238 1357 dbSNP
rs1361452249 1363 dbSNP
rs974199938 1364 dbSNP
rs1245639116 1368 dbSNP
rs1264986113 1370 dbSNP
rs1487528887 1383 dbSNP
rs964204907 1396 dbSNP
rs1248819016 1397 dbSNP
rs1464733581 1411 dbSNP
rs1187024671 1413 dbSNP
rs782111351 1422 dbSNP
rs1387661519 1424 dbSNP
rs1424953005 1426 dbSNP
rs910299661 1427 dbSNP
rs985808844 1431 dbSNP
rs189368436 1445 dbSNP
rs1455918398 1469 dbSNP
rs1290276328 1491 dbSNP
rs539197376 1491 dbSNP
rs1388827008 1502 dbSNP
rs1434129755 1502 dbSNP
rs568830145 1503 dbSNP
rs1228858569 1509 dbSNP
rs1311916701 1510 dbSNP
rs956820259 1518 dbSNP
rs1320014793 1522 dbSNP
rs13232120 1527 dbSNP
rs1269045887 1537 dbSNP
rs1328696031 1539 dbSNP
rs1000695936 1540 dbSNP
rs1207036345 1546 dbSNP
rs775412593 1555 dbSNP
rs1483783211 1557 dbSNP
rs1044930137 1565 dbSNP
rs1181843457 1566 dbSNP
rs1013638949 1575 dbSNP
rs1421551090 1578 dbSNP
rs535452334 1582 dbSNP
rs1160692216 1585 dbSNP
rs1156466661 1586 dbSNP
rs1412288140 1586 dbSNP
rs1456425377 1586 dbSNP
rs114864981 1590 dbSNP
rs547337845 1591 dbSNP
rs1448409863 1593 dbSNP
rs1302197645 1594 dbSNP
rs1376834972 1598 dbSNP
rs782221542 1612 dbSNP
rs1289117540 1619 dbSNP
rs528662138 1623 dbSNP
rs1265214622 1624 dbSNP
rs1313170686 1627 dbSNP
rs1047477849 1631 dbSNP
rs1481879837 1632 dbSNP
rs930023812 1634 dbSNP
rs564566926 1645 dbSNP
rs568366513 1646 dbSNP
rs550109332 1648 dbSNP
rs1179643650 1656 dbSNP
rs1426750740 1657 dbSNP
rs1414855455 1665 dbSNP
rs911350656 1666 dbSNP
rs1357189094 1677 dbSNP
rs563814648 1690 dbSNP
rs541789878 1701 dbSNP
rs1308553967 1705 dbSNP
rs1370089162 1706 dbSNP
rs782648082 1714 dbSNP
rs1408017702 1716 dbSNP
rs1276838118 1719 dbSNP
rs1368527973 1720 dbSNP
rs1219034033 1721 dbSNP
rs1299707526 1722 dbSNP
rs1309602561 1734 dbSNP
rs1206586254 1741 dbSNP
rs1274535608 1744 dbSNP
rs557253572 1748 dbSNP
rs1482445358 1754 dbSNP
rs923072806 1761 dbSNP
rs574517238 1762 dbSNP
rs1478178548 1771 dbSNP
rs988192398 1778 dbSNP
rs1422879218 1780 dbSNP
rs561629716 1782 dbSNP
rs540172038 1783 dbSNP
rs536704368 1784 dbSNP
rs1325555488 1785 dbSNP
rs183861898 1786 dbSNP
rs1436080616 1791 dbSNP
rs1291998168 1794 dbSNP
rs1367869259 1800 dbSNP
rs1229522585 1803 dbSNP
rs1297550914 1810 dbSNP
rs979311791 1811 dbSNP
rs1291450165 1813 dbSNP
rs1451668311 1814 dbSNP
rs1220442767 1835 dbSNP
rs1244558633 1839 dbSNP
rs191570197 1848 dbSNP
rs1023452079 1853 dbSNP
rs1013434859 1854 dbSNP
rs1447639035 1858 dbSNP
rs1164897835 1865 dbSNP
rs1414710371 1866 dbSNP
rs896550325 1868 dbSNP
rs1404826701 1870 dbSNP
rs1025751572 1871 dbSNP
rs1436305198 1873 dbSNP
rs994573429 1876 dbSNP
rs1363429583 1877 dbSNP
rs539621023 1887 dbSNP
rs1450900646 1894 dbSNP
rs575205721 1912 dbSNP
rs898535595 1924 dbSNP
rs115967804 1925 dbSNP
rs187787926 1928 dbSNP
rs1330715280 1929 dbSNP
rs942931586 1930 dbSNP
rs1208945734 1933 dbSNP
rs549220241 1934 dbSNP
rs1463375580 1943 dbSNP
rs184954271 1952 dbSNP
rs1237927738 1954 dbSNP
rs890048736 1959 dbSNP
rs1161484690 1962 dbSNP
rs17145738 1963 dbSNP
rs1458002329 1964 dbSNP
rs535054950 1966 dbSNP
rs934197524 1968 dbSNP
rs1158698766 1976 dbSNP
rs1416459035 1981 dbSNP
rs923009708 1982 dbSNP
rs1340356509 2013 dbSNP
rs987940449 2027 dbSNP
rs1446686387 2033 dbSNP
rs192890265 2034 dbSNP
rs571127480 2035 dbSNP
rs1228701723 2040 dbSNP
rs1267087731 2046 dbSNP
rs1348292740 2047 dbSNP
rs935081517 2052 dbSNP
rs1279271493 2053 dbSNP
rs148762597 2058 dbSNP
rs1185668025 2062 dbSNP
rs1254154132 2064 dbSNP
rs1472950047 2069 dbSNP
rs1181742894 2072 dbSNP
rs924903773 2073 dbSNP
rs1479224792 2076 dbSNP
rs1173478022 2086 dbSNP
rs1401921255 2087 dbSNP
rs1413309514 2089 dbSNP
rs979113559 2091 dbSNP
rs1310386938 2099 dbSNP
rs147292859 2110 dbSNP
rs1371933668 2113 dbSNP
rs1409843381 2116 dbSNP
rs969267343 2119 dbSNP
rs1287327146 2120 dbSNP
rs1333583666 2122 dbSNP
rs1023587886 2123 dbSNP
rs1344025336 2133 dbSNP
rs1208709411 2135 dbSNP
rs1276614090 2137 dbSNP
rs569789560 2141 dbSNP
rs548307367 2142 dbSNP
rs992384303 2143 dbSNP
rs1204470343 2144 dbSNP
rs782431290 2152 dbSNP
rs530024249 2168 dbSNP
rs1199816365 2169 dbSNP
rs78665751 2173 dbSNP
rs568457298 2174 dbSNP
rs1171053910 2176 dbSNP
rs1391251501 2178 dbSNP
rs1429867005 2180 dbSNP
rs1306925187 2189 dbSNP
rs1393653180 2193 dbSNP
rs1388217580 2194 dbSNP
rs540516337 2196 dbSNP
rs1330311593 2209 dbSNP
rs1342721147 2223 dbSNP
rs1227551234 2230 dbSNP
rs782518221 2235 dbSNP
rs1006873149 2236 dbSNP
rs1489505182 2238 dbSNP
rs1210727556 2240 dbSNP
rs143931750 2243 dbSNP
rs1266872199 2244 dbSNP
rs890017402 2245 dbSNP
rs1190865180 2247 dbSNP
rs1249213824 2248 dbSNP
rs1449433862 2249 dbSNP
rs1168947676 2256 dbSNP
rs1051388383 2260 dbSNP
rs1370898650 2261 dbSNP
rs1458940848 2270 dbSNP
rs1163482870 2271 dbSNP
rs1389514314 2277 dbSNP
rs1322358551 2293 dbSNP
rs1438464772 2293 dbSNP
rs1365627429 2294 dbSNP
rs1434372150 2298 dbSNP
rs934142720 2298 dbSNP
rs1293338213 2304 dbSNP
rs1323596828 2315 dbSNP
rs564412337 2326 dbSNP
rs1265116981 2327 dbSNP
rs891927051 2347 dbSNP
rs1210789400 2349 dbSNP
rs1249106313 2356 dbSNP
rs1053700776 2357 dbSNP
rs935074212 2367 dbSNP
rs1425068884 2368 dbSNP
rs925039344 2369 dbSNP
rs188404096 2370 dbSNP
rs1459586633 2379 dbSNP
rs1160924669 2381 dbSNP
rs1389183830 2385 dbSNP
rs947726694 2391 dbSNP
rs1456457437 2394 dbSNP
rs1287054535 2398 dbSNP
rs1381208696 2404 dbSNP
rs916498804 2407 dbSNP
rs781854380 2408 dbSNP
rs1353636233 2423 dbSNP
rs545645270 2423 dbSNP
rs1268937319 2431 dbSNP
rs1328910490 2436 dbSNP
rs1214038962 2439 dbSNP
rs1258308318 2441 dbSNP
rs1483891353 2446 dbSNP
rs1200357564 2451 dbSNP
rs992123619 2457 dbSNP
rs575417982 2468 dbSNP
rs1256278374 2472 dbSNP
rs375250550 2474 dbSNP
rs918403095 2483 dbSNP
rs1183919865 2486 dbSNP
rs541978938 2493 dbSNP
rs782802903 2500 dbSNP
rs782145386 2506 dbSNP
rs1312184566 2507 dbSNP
rs1016997603 2510 dbSNP
rs1411665352 2521 dbSNP
rs1289249901 2534 dbSNP
rs1350047359 2538 dbSNP
rs1006841897 2542 dbSNP
rs1313148474 2543 dbSNP
rs1233235504 2545 dbSNP
rs548615118 2556 dbSNP
rs1484409201 2563 dbSNP
rs1206631887 2573 dbSNP
rs1252116168 2575 dbSNP
rs1480135255 2576 dbSNP
rs1175088249 2586 dbSNP
rs1030082767 2604 dbSNP
rs1433494845 2611 dbSNP
rs1172941999 2618 dbSNP
rs745944177 2630 dbSNP
rs1431725597 2632 dbSNP
rs1353977124 2640 dbSNP
rs892063863 2640 dbSNP
rs1440373044 2645 dbSNP
rs782105929 2648 dbSNP
rs1295494313 2655 dbSNP
rs781961819 2656 dbSNP
rs574483153 2658 dbSNP
rs1368771973 2670 dbSNP
rs147468786 2671 dbSNP
rs1301924915 2682 dbSNP
rs1344876862 2683 dbSNP
rs1229763098 2690 dbSNP
rs1274789122 2695 dbSNP
rs1306399623 2708 dbSNP
rs1202019010 2709 dbSNP
rs1248027728 2710 dbSNP
rs1061490 2715 dbSNP
rs377188066 2724 dbSNP
rs116726036 2726 dbSNP
rs1043535304 2727 dbSNP
rs1451295492 2751 dbSNP
rs1169134210 2754 dbSNP
rs947695424 2755 dbSNP
rs1418971307 2769 dbSNP
rs1408224450 2773 dbSNP
rs1167185637 2779 dbSNP
rs1350650295 2784 dbSNP
rs1440659333 2793 dbSNP
rs571023321 2809 dbSNP
rs1367758670 2818 dbSNP
rs916214516 2821 dbSNP
rs1360663219 2824 dbSNP
rs1291606462 2829 dbSNP
rs1321996917 2830 dbSNP
rs1056536637 2832 dbSNP
rs939254089 2833 dbSNP
rs918527605 2835 dbSNP
rs1271107994 2836 dbSNP
rs1466075089 2838 dbSNP
rs1189158414 2840 dbSNP
rs972574037 2846 dbSNP
rs1241386313 2859 dbSNP
rs1474487865 2863 dbSNP
rs1183624382 2864 dbSNP
rs962556840 2867 dbSNP
rs534631506 2873 dbSNP
rs909960173 2878 dbSNP
rs1391303869 2887 dbSNP
rs985473383 2906 dbSNP
rs954128876 2910 dbSNP
rs1318283196 2911 dbSNP
rs1325146992 2918 dbSNP
rs534800195 2923 dbSNP
rs1285484800 2926 dbSNP
rs1355532403 2927 dbSNP
rs782117846 2928 dbSNP
rs998609290 2934 dbSNP
rs1291000513 2947 dbSNP
rs1330960195 2951 dbSNP
rs1205467123 2952 dbSNP
rs1283510157 2952 dbSNP
rs1445262938 2952 dbSNP
rs12531884 2954 dbSNP
rs1238193142 2957 dbSNP
rs200743495 2959 dbSNP
rs1032365166 2964 dbSNP
rs569952292 2970 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gauacCCACCCUGUCUCUCcc 5'
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Target 5' -gagaGGAGAGAGAGAGAGaa 3'
 		1 - 20
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000305632.5 | 3UTR | AGGAGAGGAGAGAGAGAGAGAAUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000305632.5 | 3UTR | GAGAGGAGAGAGAGAGAGAAUGUGAUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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