pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SMOC1   
Synonyms OAS
Description SPARC related modular calcium binding 1
Transcript NM_001034852   
Other Transcripts NM_022137   
Expression
Putative miRNA Targets on SMOC1
3'UTR of SMOC1
(miRNA target sites are highlighted)
>SMOC1|NM_001034852|3'UTR
   1 GGAGCAGAAAACCCAAGGGCAGGTGGAGAGTCCAGGGAGGCAGGATGGATCACCAGACACCTAACCTTCAGCGTTGCCCA
  81 TGGCCCTGCCACATCCCGTGTAACATAAGTGGTGCCCACCATGTTTGCACTTTTAATAACTCTTACTTGCGTGTTTTGTT
 161 TTTGGTTTCATTTTAAAACACCAATATCTAATACCACAGTGGGAAAAGGAAAGGGAAGAAAGACTTTATTCTCTCTCTTA
 241 TTGTAAGTTTTTGGATCTGCTACTGACAACTTTTAGAGGGTTTTGGGGGGGTGGGGGAGGGTGTTGTTGGGGCTGAGAAG
 321 AAAGAGATTTATATGCTGTATATAAATATATATGTAAATTGTATAGTTCTTTTGTACAGGCATTGGCATTGCTGTTTGTT
 401 TATTTCTCTCCCTCTGCCTGCTGTGGGTGGTGGGCACTCTGGACACATAGTCCAGCTTTCTAAAATCCAGGACTCTATCC
 481 TGGGCCTACTAAACTTCTGTTTGGAGACTGACCCTTGTGTATAAAGACGGGAGTCCTGCAATTGTACTGCGGACTCCACG
 561 AGTTCTTTTCTGGTGGGAGGACTATATTGCCCCATGCCATTAGTTGTCAAAATTGATAAGTCACTTGGCTCTCGGCCTTG
 641 TCCAGGGAGGTTGGGCTAAGGAGAGATGGAAACTGCCCTGGGAGAGGAAGGGAGTCCAGATCCCATGAATAGCCCACACA
 721 GGTACCGGCTCTCAGAGGGTCCGTGCATTCCTGCTCTCCGGACCCCCAAAGGGCCCAGCATTGGTGGGTGCACCAGTATC
 801 TTAGTGACCCTCGGAGCAAATTATCCACAAAGGATTTGCATTACGTCACTCGAAACGTTTTCATCCATGCTTAGCATCTA
 881 CTCTGTATAACGCATGAGAGGGGAGGCAAAGAAGAAAAAGACACACAGAAGGGCCTTTAAAAAAGTAGATATTTAATATC
 961 TAAGCAGGGGAGGGGACAGGACAGAAAGCCTGCACTGAGGGGTGCGGTGCCAACAGGGAAACTCTTCACCTCCCTGCAAA
1041 CCTACCAGTGAGGCTCCCAGAGACGCAGCTGTCTCAGTGCCAGGGGCAGATTGGGTGTGACCTCTCCACTCCTCCATCTC
1121 CTGCTGTTGTCCTAGTGGCTATCACAGGCCTGGGTGGGTGGGTTGGGGGAGGTGTCAGTCACCTTGTTGGTAACACTAAA
1201 GTTGTTTTGTTGGTTTTTTAAAAACCCAATACTGAGGTTCTTCCTGTTCCCTCAAGTTTTCTTATGGGCTTCCAGGCTTT
1281 AAGCTAATTCCAGAAGTAAAACTGATCTTGGGTTTCCTATTCTGCCTCCCCTAGAAGGGCAGGGGTGATAACCCAGCTAC
1361 AGGGAAATCCCGGCCCAGCTTTCCACAGGCATCACAGGCATCTTCCGCGGATTCTAGGGTGGGCTGCCCAGCCTTCTGGT
1441 CTGAGGCGCAGCTCCCTCTGCCCAGGTGCTGTGCCTATTCAAGTGGCCTTCAGGCAGAGCAGCAAGTGGCCCTTAGCGCC
1521 CCTTCCCATAAGCAGCTGTGGTGGCAGTGAGGGAGGTTGGGTAGCCCTGGACTGGTCCCCTCCTCAGATCACCCTTGCAA
1601 ATCTGGCCTCATCTTGTATTCCAACCCGACATCCCTAAAAGTACCTCCACCCGTTCCGGGTCTGGAAGGCGTTGGCACCA
1681 CAAGCACTGTCCCTGTGGGAGGAGCACAACCTTCTCGGGACAGGATCTGATGGGGTCTTGGGCTAAAGGAGGTCCCTGCT
1761 GTCCTGGAGAAAGTCCTAGAGGTTATCTCAGGAATGACTGGTGGCCCTGCCCCAACGTGGAAAGGTGGGAAGGAAGCCTT
1841 CTCCCATTAGCCCCAATGAGAGAACTCAACGTGCCGGAGCTGAGTGGGCCTTGCACGAGACACTGGCCCCACTTTCAGGC
1921 CTGGAGGAAGCATGCACACATGGAGACGGCGCCTGCCTGTAGATGTTTGGATCTTCGAGATCTCCCCAGGCATCTTGTCT
2001 CCCACAGGATCGTGTGTGTAGGTGGTGTTGTGTGGTTTTCCTTTGTGAAGGAGAGAGGGAAACTATTTGTAGCTTGTTTT
2081 ATAAAAAATAAAAAATGGGTAAATCTTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cggUUCCCUUACC------GUCCCUUUa 5'
             |:||| : ||      |||||||| 
Target 5' ctgAGGGGTGCGGTGCCAACAGGGAAAc 3'
995 - 1022 153.00 -19.10
2
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            ::| |||: |  ||||||| 
Target 5' tgTGAAGGAGAG--AGGGAAAc 3'
2044 - 2063 152.00 -14.10
3
miRNA  3' cgGUUCCC-UUA------C--CGUCCCUUUa 5'
            ||:||| :||      |   |||||||| 
Target 5' ggCAGGGGTGATAACCCAGCTACAGGGAAAt 3'
1338 - 1368 148.00 -20.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1179798 81 ClinVar
COSM7894425 1 COSMIC
COSN31498861 14 COSMIC
COSN26995828 27 COSMIC
COSN30471586 38 COSMIC
COSN30474649 41 COSMIC
COSN30473617 44 COSMIC
COSN30180704 52 COSMIC
COSN30523177 55 COSMIC
COSN30109137 59 COSMIC
COSN30493640 73 COSMIC
COSN7025247 74 COSMIC
COSN30450005 80 COSMIC
COSN510799 81 COSMIC
COSN30758225 84 COSMIC
COSN31566862 86 COSMIC
COSN30186935 87 COSMIC
COSN30468626 97 COSMIC
COSN30455479 98 COSMIC
COSN30101405 107 COSMIC
COSN17132580 110 COSMIC
COSN30105495 157 COSMIC
COSN30162191 170 COSMIC
COSN31525873 185 COSMIC
COSN20085335 189 COSMIC
COSN8387149 238 COSMIC
COSN19507632 399 COSMIC
COSN31961000 529 COSMIC
COSN8156495 715 COSMIC
COSN20981518 827 COSMIC
COSN8848924 846 COSMIC
COSN5172170 899 COSMIC
COSN26774337 946 COSMIC
COSN6257547 1259 COSMIC
COSN23498266 1408 COSMIC
COSN8156496 1409 COSMIC
COSN15062860 1519 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751567810 1 dbSNP
rs1354562365 2 dbSNP
rs1211820190 11 dbSNP
rs1291792043 13 dbSNP
rs1468707398 14 dbSNP
rs1301687926 15 dbSNP
rs760656651 15 dbSNP
rs1187858887 16 dbSNP
rs566181977 19 dbSNP
rs201525786 20 dbSNP
rs770017964 23 dbSNP
rs368841209 24 dbSNP
rs936350059 26 dbSNP
rs1456090383 27 dbSNP
rs749646389 28 dbSNP
rs769106450 29 dbSNP
rs774707485 39 dbSNP
rs373029308 43 dbSNP
rs949190906 45 dbSNP
rs770497921 49 dbSNP
rs1465301406 62 dbSNP
rs754560347 66 dbSNP
rs1464704561 69 dbSNP
rs184678642 73 dbSNP
rs370194954 74 dbSNP
rs7152085 81 dbSNP
rs886293554 84 dbSNP
rs1378933156 92 dbSNP
rs1027609797 96 dbSNP
rs1440913141 98 dbSNP
rs1004676638 99 dbSNP
rs1012758803 118 dbSNP
rs77498272 122 dbSNP
rs757925210 123 dbSNP
rs1212703307 124 dbSNP
rs1337857913 128 dbSNP
rs1220069311 135 dbSNP
rs898486266 138 dbSNP
rs1278366864 139 dbSNP
rs1240780568 141 dbSNP
rs1379073045 142 dbSNP
rs574982474 151 dbSNP
rs995508330 152 dbSNP
rs1028526199 163 dbSNP
rs536000675 169 dbSNP
rs1401713909 178 dbSNP
rs954260656 181 dbSNP
rs554318128 182 dbSNP
rs1008480736 185 dbSNP
rs924263028 186 dbSNP
rs1261107998 195 dbSNP
rs777615788 202 dbSNP
rs868049820 204 dbSNP
rs1489279193 210 dbSNP
rs189175828 214 dbSNP
rs966914838 219 dbSNP
rs1424675964 220 dbSNP
rs1422761827 223 dbSNP
rs575114117 230 dbSNP
rs978232692 232 dbSNP
rs1379192675 238 dbSNP
rs1487138539 238 dbSNP
rs1435251804 242 dbSNP
rs990137929 244 dbSNP
rs1032115560 248 dbSNP
rs957688660 250 dbSNP
rs776064218 257 dbSNP
rs1352692851 259 dbSNP
rs1263642792 268 dbSNP
rs1242608913 271 dbSNP
rs1234859645 278 dbSNP
rs546239570 282 dbSNP
rs1273546369 285 dbSNP
rs1349761805 285 dbSNP
rs1338771028 286 dbSNP
rs990518321 288 dbSNP
rs1298307921 290 dbSNP
rs1366445041 292 dbSNP
rs1050571121 293 dbSNP
rs1303859432 299 dbSNP
rs1313214673 300 dbSNP
rs912084919 302 dbSNP
rs944778604 305 dbSNP
rs916253961 307 dbSNP
rs897825877 308 dbSNP
rs1489574533 311 dbSNP
rs759053173 313 dbSNP
rs1265103537 316 dbSNP
rs1209149135 318 dbSNP
rs1357045622 321 dbSNP
rs1273859492 336 dbSNP
rs930662066 339 dbSNP
rs1277842360 340 dbSNP
rs1431849092 351 dbSNP
rs564499094 354 dbSNP
rs1328576430 357 dbSNP
rs1322055041 360 dbSNP
rs1246249440 362 dbSNP
rs1487609208 363 dbSNP
rs1392139900 374 dbSNP
rs949260887 380 dbSNP
rs1193207520 387 dbSNP
rs1269183202 392 dbSNP
rs1049413267 403 dbSNP
rs11540035 407 dbSNP
rs1013143002 420 dbSNP
rs1476220886 431 dbSNP
rs907688091 434 dbSNP
rs1197957997 441 dbSNP
rs1452089434 443 dbSNP
rs1254843084 444 dbSNP
rs1215598462 447 dbSNP
rs907066593 448 dbSNP
rs1257601037 450 dbSNP
rs770876370 451 dbSNP
rs1378356157 454 dbSNP
rs1037522592 458 dbSNP
rs898621535 466 dbSNP
rs1421496841 489 dbSNP
rs1159159294 496 dbSNP
rs931406422 499 dbSNP
rs1031465057 502 dbSNP
rs1398899743 508 dbSNP
rs1331515887 512 dbSNP
rs1411262648 512 dbSNP
rs1399682021 514 dbSNP
rs1433839089 517 dbSNP
rs1294864074 518 dbSNP
rs957221781 523 dbSNP
rs879530920 526 dbSNP
rs889800488 529 dbSNP
rs557738546 530 dbSNP
rs1019891775 532 dbSNP
rs1237636777 540 dbSNP
rs1205362510 542 dbSNP
rs989840628 543 dbSNP
rs902661508 545 dbSNP
rs1022945714 547 dbSNP
rs953637025 548 dbSNP
rs986374163 551 dbSNP
rs912053158 552 dbSNP
rs1376861381 553 dbSNP
rs1356438375 556 dbSNP
rs944912860 560 dbSNP
rs45447998 561 dbSNP
rs1032085419 563 dbSNP
rs1333106769 571 dbSNP
rs111757119 572 dbSNP
rs1377035881 575 dbSNP
rs547940516 581 dbSNP
rs1156686810 582 dbSNP
rs930609095 591 dbSNP
rs372675264 592 dbSNP
rs1177810347 598 dbSNP
rs559830945 600 dbSNP
rs1471202107 601 dbSNP
rs990588537 602 dbSNP
rs1049080582 617 dbSNP
rs1187085367 618 dbSNP
rs1266188585 618 dbSNP
rs1282870534 629 dbSNP
rs1023278652 631 dbSNP
rs970410772 634 dbSNP
rs982419249 635 dbSNP
rs1177756021 636 dbSNP
rs1045715506 646 dbSNP
rs907033931 647 dbSNP
rs1415017637 652 dbSNP
rs749531821 665 dbSNP
rs907827605 667 dbSNP
rs1441464055 673 dbSNP
rs527413867 674 dbSNP
rs1412998714 676 dbSNP
rs1161213137 679 dbSNP
rs1403587086 680 dbSNP
rs1411711748 700 dbSNP
rs1164352215 702 dbSNP
rs1475644494 706 dbSNP
rs1403030846 710 dbSNP
rs1031391405 712 dbSNP
rs1191907787 718 dbSNP
rs182143181 727 dbSNP
rs111784304 728 dbSNP
rs1218549766 730 dbSNP
rs761838383 734 dbSNP
rs533243051 743 dbSNP
rs59918631 744 dbSNP
rs1336438423 755 dbSNP
rs144239370 760 dbSNP
rs78968793 761 dbSNP
rs1362378316 768 dbSNP
rs1290482055 773 dbSNP
rs966146301 774 dbSNP
rs944076580 775 dbSNP
rs972216517 781 dbSNP
rs184347786 783 dbSNP
rs45445899 787 dbSNP
rs1325246492 797 dbSNP
rs1443542373 799 dbSNP
rs45486993 802 dbSNP
rs1168813010 809 dbSNP
rs930728988 811 dbSNP
rs902798678 813 dbSNP
rs867799717 814 dbSNP
rs1000192835 816 dbSNP
rs1213701527 823 dbSNP
rs915908141 827 dbSNP
rs1032490097 829 dbSNP
rs146575108 837 dbSNP
rs761131829 841 dbSNP
rs928545547 844 dbSNP
rs1204962640 845 dbSNP
rs1023413051 846 dbSNP
rs535688780 851 dbSNP
rs554381260 852 dbSNP
rs1003246708 853 dbSNP
rs572653180 869 dbSNP
rs1052937598 877 dbSNP
rs892988366 884 dbSNP
rs1461646506 887 dbSNP
rs1015013338 892 dbSNP
rs961950128 895 dbSNP
rs763918288 897 dbSNP
rs973311492 901 dbSNP
rs1394941889 904 dbSNP
rs1011317524 914 dbSNP
rs1476457017 917 dbSNP
rs2273780 928 dbSNP
rs953240326 930 dbSNP
rs985489528 932 dbSNP
rs1480726049 960 dbSNP
rs911345783 968 dbSNP
rs1477288061 969 dbSNP
rs539971396 971 dbSNP
rs944028497 975 dbSNP
rs1207680865 976 dbSNP
rs1189335336 983 dbSNP
rs889408260 990 dbSNP
rs1007854528 991 dbSNP
rs1236402267 997 dbSNP
rs766736257 1000 dbSNP
rs1307155159 1001 dbSNP
rs1390919167 1003 dbSNP
rs369843484 1004 dbSNP
rs923939846 1006 dbSNP
rs754145236 1009 dbSNP
rs1410812891 1017 dbSNP
rs1464782021 1026 dbSNP
rs966283713 1030 dbSNP
rs1333953648 1031 dbSNP
rs1437100828 1037 dbSNP
rs759884939 1038 dbSNP
rs993736031 1040 dbSNP
rs1357909286 1046 dbSNP
rs1180412337 1047 dbSNP
rs1054069926 1048 dbSNP
rs139737105 1051 dbSNP
rs1252158698 1054 dbSNP
rs1012460964 1059 dbSNP
rs751429988 1064 dbSNP
rs952348862 1065 dbSNP
rs576404999 1066 dbSNP
rs984893234 1073 dbSNP
rs1212821692 1076 dbSNP
rs1351357144 1078 dbSNP
rs1216890795 1083 dbSNP
rs45527633 1086 dbSNP
rs1238344564 1087 dbSNP
rs906250360 1092 dbSNP
rs1003708607 1094 dbSNP
rs1014570592 1096 dbSNP
rs1280266782 1098 dbSNP
rs375761979 1110 dbSNP
rs994697617 1114 dbSNP
rs1214891549 1115 dbSNP
rs915983915 1123 dbSNP
rs1277713286 1131 dbSNP
rs1027549817 1132 dbSNP
rs953211687 1133 dbSNP
rs543752201 1141 dbSNP
rs562648261 1149 dbSNP
rs1257586093 1151 dbSNP
rs911721477 1155 dbSNP
rs899145564 1156 dbSNP
rs45622332 1157 dbSNP
rs1454817446 1159 dbSNP
rs1190880464 1160 dbSNP
rs1425270986 1161 dbSNP
rs45576440 1163 dbSNP
rs1411670321 1165 dbSNP
rs995468069 1165 dbSNP
rs45542132 1167 dbSNP
rs1423596597 1179 dbSNP
rs981454884 1181 dbSNP
rs928513828 1183 dbSNP
rs1260843935 1188 dbSNP
rs1313962407 1196 dbSNP
rs934550366 1198 dbSNP
rs977255012 1214 dbSNP
rs189236198 1215 dbSNP
rs1334389975 1220 dbSNP
rs1300141575 1221 dbSNP
rs866346218 1225 dbSNP
rs1338886894 1227 dbSNP
rs116283028 1230 dbSNP
rs752367262 1241 dbSNP
rs915532720 1255 dbSNP
rs1291244724 1258 dbSNP
rs1007823639 1262 dbSNP
rs1418047225 1272 dbSNP
rs948295138 1276 dbSNP
rs1166625896 1285 dbSNP
rs1476672650 1309 dbSNP
rs1045218956 1311 dbSNP
rs1274022417 1313 dbSNP
rs1040667606 1317 dbSNP
rs1193690107 1317 dbSNP
rs1265221615 1330 dbSNP
rs1211823376 1331 dbSNP
rs1468101253 1339 dbSNP
rs896857246 1341 dbSNP
rs906714311 1343 dbSNP
rs527474164 1344 dbSNP
rs1215785825 1348 dbSNP
rs61612924 1360 dbSNP
rs1269956742 1370 dbSNP
rs1228646147 1371 dbSNP
rs1036548386 1372 dbSNP
rs1301888769 1373 dbSNP
rs757865112 1375 dbSNP
rs3742912 1379 dbSNP
rs1006808541 1380 dbSNP
rs1327376921 1384 dbSNP
rs1027520428 1390 dbSNP
rs1263277086 1392 dbSNP
rs1168242354 1401 dbSNP
rs888998678 1407 dbSNP
rs3742913 1408 dbSNP
rs541985823 1409 dbSNP
rs1007432496 1410 dbSNP
rs1479172808 1418 dbSNP
rs1018756054 1419 dbSNP
rs966301414 1422 dbSNP
rs1436244318 1423 dbSNP
rs976845776 1424 dbSNP
rs1035684057 1425 dbSNP
rs1380173938 1426 dbSNP
rs751544588 1428 dbSNP
rs1234159114 1431 dbSNP
rs3742914 1433 dbSNP
rs989449162 1439 dbSNP
rs538933648 1449 dbSNP
rs1385846358 1456 dbSNP
rs948262563 1466 dbSNP
rs1411361520 1467 dbSNP
rs557274944 1477 dbSNP
rs1172825030 1478 dbSNP
rs145798773 1486 dbSNP
rs943778279 1488 dbSNP
rs148985334 1492 dbSNP
rs781285346 1496 dbSNP
rs1442773044 1517 dbSNP
rs769599437 1518 dbSNP
rs1232461211 1519 dbSNP
rs896826239 1520 dbSNP
rs929636285 1523 dbSNP
rs867329536 1526 dbSNP
rs79460286 1529 dbSNP
rs888039633 1532 dbSNP
rs930402818 1539 dbSNP
rs1350698221 1550 dbSNP
rs1349312899 1558 dbSNP
rs1279694018 1582 dbSNP
rs1443885666 1584 dbSNP
rs1006367123 1593 dbSNP
rs80262145 1601 dbSNP
rs566315460 1607 dbSNP
rs1469552746 1614 dbSNP
rs1316154940 1615 dbSNP
rs147757192 1617 dbSNP
rs1400107993 1623 dbSNP
rs1407305008 1627 dbSNP
rs1194633031 1628 dbSNP
rs1471250440 1629 dbSNP
rs1237994186 1632 dbSNP
rs558285075 1634 dbSNP
rs34130244 1647 dbSNP
rs888799261 1653 dbSNP
rs1007419347 1654 dbSNP
rs558808751 1658 dbSNP
rs956032053 1659 dbSNP
rs1364892271 1660 dbSNP
rs901674194 1661 dbSNP
rs1332167318 1665 dbSNP
rs141113901 1670 dbSNP
rs537064652 1671 dbSNP
rs1400733979 1672 dbSNP
rs1161563597 1673 dbSNP
rs1021516505 1679 dbSNP
rs969020427 1680 dbSNP
rs1319017794 1681 dbSNP
rs1458888326 1685 dbSNP
rs536812912 1705 dbSNP
rs1164460432 1710 dbSNP
rs761185178 1711 dbSNP
rs989584788 1713 dbSNP
rs181239668 1717 dbSNP
rs1375954577 1718 dbSNP
rs911049578 1735 dbSNP
rs1217228830 1736 dbSNP
rs573936416 1743 dbSNP
rs1444328730 1749 dbSNP
rs372662734 1752 dbSNP
rs1272056525 1758 dbSNP
rs541763428 1762 dbSNP
rs1213929935 1764 dbSNP
rs1336553404 1771 dbSNP
rs575549912 1775 dbSNP
rs1293112944 1777 dbSNP
rs969404902 1783 dbSNP
rs981027326 1795 dbSNP
rs1362487171 1796 dbSNP
rs1271868891 1797 dbSNP
rs1336310452 1799 dbSNP
rs1368869179 1800 dbSNP
rs1325353250 1803 dbSNP
rs1462143629 1807 dbSNP
rs1351859774 1808 dbSNP
rs1168730522 1811 dbSNP
rs943914452 1812 dbSNP
rs976434680 1815 dbSNP
rs918343759 1816 dbSNP
rs571912935 1817 dbSNP
rs939525654 1818 dbSNP
rs1336454663 1819 dbSNP
rs1214004696 1830 dbSNP
rs1048554708 1846 dbSNP
rs888143815 1847 dbSNP
rs1203482190 1851 dbSNP
rs1307844637 1853 dbSNP
rs942267255 1854 dbSNP
rs1044706639 1857 dbSNP
rs545555700 1865 dbSNP
rs919428630 1866 dbSNP
rs930370080 1871 dbSNP
rs1441775951 1874 dbSNP
rs1048809014 1876 dbSNP
rs1296683373 1877 dbSNP
rs888764795 1880 dbSNP
rs1355478065 1881 dbSNP
rs1420159978 1884 dbSNP
rs1475652462 1885 dbSNP
rs1433380765 1893 dbSNP
rs1170169842 1894 dbSNP
rs1173639720 1895 dbSNP
rs1434407848 1896 dbSNP
rs891891876 1898 dbSNP
rs943069117 1900 dbSNP
rs1040284183 1908 dbSNP
rs901723675 1920 dbSNP
rs1022029078 1921 dbSNP
rs998788180 1928 dbSNP
rs1208494739 1933 dbSNP
rs1053341113 1938 dbSNP
rs1347009185 1941 dbSNP
rs1280963610 1943 dbSNP
rs1235041595 1945 dbSNP
rs1305046693 1948 dbSNP
rs892989312 1948 dbSNP
rs564044129 1949 dbSNP
rs1022410387 1951 dbSNP
rs969373840 1952 dbSNP
rs1002647654 1954 dbSNP
rs1413322907 1958 dbSNP
rs1375309889 1960 dbSNP
rs1035034851 1962 dbSNP
rs1468088736 1965 dbSNP
rs1356877445 1972 dbSNP
rs147982176 1977 dbSNP
rs1419250832 1988 dbSNP
rs531411149 2002 dbSNP
rs1315710105 2003 dbSNP
rs1311780253 2004 dbSNP
rs972360643 2012 dbSNP
rs976568835 2015 dbSNP
rs1202107190 2016 dbSNP
rs919397506 2022 dbSNP
rs1483189827 2025 dbSNP
rs952238646 2026 dbSNP
rs984504287 2027 dbSNP
rs750458860 2029 dbSNP
rs185808601 2032 dbSNP
rs1290456656 2033 dbSNP
rs141666125 2044 dbSNP
rs1193084751 2066 dbSNP
rs1355218132 2068 dbSNP
rs1294330565 2073 dbSNP
rs1398282155 2076 dbSNP
rs943141991 2083 dbSNP
rs1430570161 2090 dbSNP
rs528885359 2092 dbSNP
rs548153484 2100 dbSNP
rs1453860790 2109 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cggUUCCCUUACCGUCCCUUUa 5'
             || ||||    ||||||: 
Target 5' ---AAAGGAA----AGGGAAGa 3'
1 - 15
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000381280.4 | 3UTR | AAAGGAAAGGGAAGAAAGACUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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