pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLC41A1   
Synonyms MgtE
Description solute carrier family 41 member 1
Transcript NM_173854   
Expression
Putative miRNA Targets on SLC41A1
3'UTR of SLC41A1
(miRNA target sites are highlighted)
>SLC41A1|NM_173854|3'UTR
   1 CTTGGTCACTCAACATTTTCCCCATCCCTCTGCACTTTCTATTTGAAATTTTTCTTTTGTTCCCCTGTCCCTCCTCCACC
  81 CCACACTCCCACCTCTTTCTAGGACTTCACTTTGATACCAAATTCTCATTATTTTCAATGGGAATTTTTATACATTGAGC
 161 CAAGTTTGTATAGCAAGAATTTGGGAAACACAGATGGCCTGAGATAAGCAGTACAAGTAGGTTTTTGAGACAATCACCAA
 241 GTGCAGTTTCATGGTGGGTGCCTCCAGGTGATGTGGACTGGAGCAGGGGAGTTTTGTCTGGAATCTGGGGACATGGGGTT
 321 TGGCTTTAGCAACCTGTCTTGGCCCTAATGAGAAACCCTTTGTAAGTGGGCTCTGGATTTTTGGTTTTGTTTTCTTTTTA
 401 TCTGTTTTGTTTTATTTTTGGTTTTGGTTGAACAGAGGGACAGAAGAATAAGTAACACTCCCAAACACAGACATACTTTT
 481 GTAGAAGTGGACCAACTTCAAAGCTCTGGACAGGAGACACCTGCTCCAGGCCCCTGTGATCCCAGTTCTGTTCTCTTGCC
 561 CTCTGGACCTAAGCGTTCCCACTCGCAGAAAGAGTAAGGTGGACTGACTTTTCAATTTGTGCACATGCCTCTTGTTCAAT
 641 GGCCTGGTCAACATCAACAACCCCTCCCTCTGATCATTTCCAGTTGATTGTCATATCCAGGAAAAAATGGAACAGTGCAC
 721 TCTTCTCCCTGTTGACCCATGTCCACCTATTGGTTCCCCAAAATCCACATTCTCCCTGGGCCCAAATGACTTTGTCTCCC
 801 TGGGCCCAGATTCTTTGTCTCTCTTCAACCTTCATCTCAAATTGTCTCTAAGCACTACCTTCCCCAGAGCTTGCCAGGTT
 881 GGGTTTTGAGATTAGGGTCAGGTCATGGGTATGTGGAGAATGGTTTGGAGGTTGAGGACAACCACAGGTGTCTCATTGCT
 961 GCCATTTCTCCTGAGGACATAATCACTTGGTCACCTTGGACCCTGTCACTTCCTAAAATTACTCGTTCTGTCATGCCATA
1041 GAGGTCAGTTTTCCTCTTTCTTGGCTTCTACCCACAAACATTCACCAATCATTTATTCGTTCATTTAGCAAATATGCAGC
1121 CTCCGCAAGATGAGCTCTCCTGCAGACAAGCATGGTCTGAAACATTCTTTGAGCAATATTTATTGAGTGCCTACTATGTG
1201 TTAGGTACTGTGCCAGGCACTGATAAGCCAGTGGTAAGGGAAACACAGCTCTAACCTCACCTCATTCTCCAGGTTACAAA
1281 GGCCATGTGCCCCTTTGAATCTGGCAGAGAAAGTTTCCTCGTTGTAAGTATTTGCATCTACTTCAAGCCAGATTCTTCTG
1361 CCTCTTTCTCCTTTCCAGACCCCTACTCTGTGCAGTGCTGACCACAGCTAGAGCCACCGCCCCATTGCTCAACCAGTATT
1441 TATTTCCCTAAACGACCCTTCCTCACATTCCCTTCCCTCCACCTCTCCTTACCAAGCACCCAAAAGAGGATTTAGAACTA
1521 GCAGGGTGGACATCATCTGGTTGTTTCTACTTTTCTCTGCCTAGCACAAAATTGGGAGAAAACTGGAGCCTCCATCCGCA
1601 GTCACACGTGTACAGATCTGGGGATTTGGATGTAGGCTTTTTCTAACTTCTCTCTCAGAAGCTTCTACAGAAACCCTTCC
1681 ATCTGTAGCCTCAAGGGCCCACCTCCAAGGGAAGGCTTAGGCAATGATCCTGTTTCTACCAACACTGCACCTTATCCCAG
1761 GAACCTGCCCTAGACCTCCAGAGACCATATTTTCTCTCCCTCCATTTCTACCCAGACCTCCAGGCCTCCTTCTGGAATCA
1841 TAGAACCGTAGAATTGGAAGGAATTTTAGAGGTTTTCTAGTTGGAGTTGTGTCCAACAGAATTCATTAACACCAGCCTGG
1921 GCTTGTTTTTCCTCCTCCCTCTGGACTTTTTTCATCTTTTCCTCCACCTCAAAAAATACTTACACACAGATTCTTCTTGT
2001 ACAGGCATCAAAACCAACTCCTCTGCCCCTAAGGCTGTGTCCCTGTGGTCTCCAGCCACCCCTACCCCAGTCACTCGCCC
2081 CTTCCTCATCTCTGGAATTTGGCCAGGCAGTCCCAGAAGACTCTGGAGTGACCTCCTTTGCCTAAAAAGCAGACAGATAG
2161 GCATGCCCCAGGCCCTGAGTGAGCAGAGGAGGACTGTAGGGTGAGAGGGAAAGAAAATGAAGGTGACTTTCATGGAAGTT
2241 TCATTTCTTTTCCCCGATTGTACCAACTGCATGTACTTTTGGCCTGGCTGCAAGGAGCAATATTGGTTTACTCTCGTATC
2321 CTTAAAAAGTTACAGAACTGTGTCTTAAGAGAATTATTTATAGTTACTATAACTGAATTGACAAATGTCAACTTAACTGA
2401 TAAATTATATTTGGTAAAATAAAGAGGACGTTTATTTAGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgGUUCCCUUACCG-UCCCUUUa 5'
            :|||  |:|||: ||||||| 
Target 5' gaTAAGCCAGTGGTAAGGGAAAc 3'
1222 - 1244 164.00 -17.00
2
miRNA  3' cgguUCCCUUACCGUCCCUUUa 5'
              ||||  ||  ||||||| 
Target 5' ctgtAGGG--TGAGAGGGAAAg 3'
2194 - 2213 154.00 -14.10
3
miRNA  3' cgguuccCUU--ACCGUCCCUUUa 5'
                 |||  |||||| |||| 
Target 5' cccctttGAATCTGGCAGAGAAAg 3'
1290 - 1313 133.00 -11.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30486265 10 COSMIC
COSN30462276 20 COSMIC
COSN30510871 22 COSMIC
COSN30142795 55 COSMIC
COSN30492837 62 COSMIC
COSN23014205 78 COSMIC
COSN30516400 81 COSMIC
COSN30509026 92 COSMIC
COSN510746 97 COSMIC
COSN30653851 128 COSMIC
COSN30531845 158 COSMIC
COSN21670918 167 COSMIC
COSN27974859 373 COSMIC
COSN30327165 586 COSMIC
COSN5364001 594 COSMIC
COSN25916444 639 COSMIC
COSN9057420 775 COSMIC
COSN16139869 827 COSMIC
COSN8429803 941 COSMIC
COSN15212392 1065 COSMIC
COSN6402214 1528 COSMIC
COSN17181607 1781 COSMIC
COSN26687617 1893 COSMIC
COSN9024826 1921 COSMIC
COSN20090441 2016 COSMIC
COSN17485680 2029 COSMIC
COSN26689570 2112 COSMIC
COSN29289321 2316 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1488406396 9 dbSNP
rs768008969 9 dbSNP
rs199729445 10 dbSNP
rs1473750268 11 dbSNP
rs373342658 13 dbSNP
rs369296885 15 dbSNP
rs1407034217 20 dbSNP
rs1365050761 28 dbSNP
rs1457572225 33 dbSNP
rs187422633 34 dbSNP
rs1458404782 35 dbSNP
rs575026553 36 dbSNP
rs775754111 38 dbSNP
rs765413008 42 dbSNP
rs185563684 43 dbSNP
rs939277931 47 dbSNP
rs1472156807 48 dbSNP
rs775905242 50 dbSNP
rs1334960016 54 dbSNP
rs1176179806 58 dbSNP
rs770302311 59 dbSNP
rs1237584386 64 dbSNP
rs1279454143 66 dbSNP
rs144681498 74 dbSNP
rs914983065 76 dbSNP
rs553840993 77 dbSNP
rs985636541 94 dbSNP
rs994683985 97 dbSNP
rs1459727965 100 dbSNP
rs1199478787 102 dbSNP
rs1256309257 119 dbSNP
rs1443612872 123 dbSNP
rs1258598082 127 dbSNP
rs1179661572 128 dbSNP
rs540362018 137 dbSNP
rs954165742 140 dbSNP
rs897630691 144 dbSNP
rs1036128183 152 dbSNP
rs1161103068 168 dbSNP
rs939086940 174 dbSNP
rs1029844554 177 dbSNP
rs1173352153 186 dbSNP
rs1291676365 191 dbSNP
rs1389737824 201 dbSNP
rs1230256204 203 dbSNP
rs1351658155 206 dbSNP
rs1380101829 215 dbSNP
rs1044710762 221 dbSNP
rs948338658 229 dbSNP
rs1232132347 248 dbSNP
rs1256224198 250 dbSNP
rs113232338 260 dbSNP
rs572119544 266 dbSNP
rs961623075 271 dbSNP
rs1379830712 275 dbSNP
rs1016296365 276 dbSNP
rs1184188698 286 dbSNP
rs915498735 287 dbSNP
rs558731162 296 dbSNP
rs559474555 313 dbSNP
rs538515698 316 dbSNP
rs1199931109 324 dbSNP
rs1005540659 327 dbSNP
rs935530226 338 dbSNP
rs1460605107 340 dbSNP
rs1168043295 341 dbSNP
rs888469985 345 dbSNP
rs1225118446 347 dbSNP
rs1432226638 352 dbSNP
rs1301805720 356 dbSNP
rs1023024769 357 dbSNP
rs1436288327 362 dbSNP
rs1348501303 366 dbSNP
rs569934242 370 dbSNP
rs1012965777 373 dbSNP
rs1273309965 374 dbSNP
rs965435346 383 dbSNP
rs556542863 394 dbSNP
rs76336704 400 dbSNP
rs1207254677 420 dbSNP
rs985467105 421 dbSNP
rs547688269 426 dbSNP
rs1406736212 428 dbSNP
rs939227112 430 dbSNP
rs1156346480 440 dbSNP
rs952652504 443 dbSNP
rs1269118503 457 dbSNP
rs1440974132 462 dbSNP
rs1027592903 472 dbSNP
rs1238778692 473 dbSNP
rs1188143271 475 dbSNP
rs902419956 481 dbSNP
rs1451403327 494 dbSNP
rs1487432368 501 dbSNP
rs1162283637 508 dbSNP
rs746434945 514 dbSNP
rs1349820471 516 dbSNP
rs1248266033 518 dbSNP
rs567302440 526 dbSNP
rs193130759 527 dbSNP
rs781537114 528 dbSNP
rs1365380692 529 dbSNP
rs1229959191 530 dbSNP
rs527406532 531 dbSNP
rs1321054983 538 dbSNP
rs1245376814 543 dbSNP
rs571716671 548 dbSNP
rs1484752442 551 dbSNP
rs1355947038 553 dbSNP
rs1248864398 561 dbSNP
rs1466374561 568 dbSNP
rs555281241 574 dbSNP
rs527780030 575 dbSNP
rs1219169954 578 dbSNP
rs551963146 584 dbSNP
rs745376118 585 dbSNP
rs906286119 589 dbSNP
rs1457042529 604 dbSNP
rs946383889 608 dbSNP
rs914905288 609 dbSNP
rs1044757012 613 dbSNP
rs985194284 615 dbSNP
rs1377780294 616 dbSNP
rs1228858549 617 dbSNP
rs1295682629 619 dbSNP
rs1314764817 619 dbSNP
rs774354125 619 dbSNP
rs893447517 620 dbSNP
rs1437591480 621 dbSNP
rs187817090 622 dbSNP
rs1054053604 625 dbSNP
rs182737224 642 dbSNP
rs1295948165 649 dbSNP
rs1331520813 653 dbSNP
rs1201947907 656 dbSNP
rs1421070598 661 dbSNP
rs191778852 662 dbSNP
rs935567220 663 dbSNP
rs1249020073 665 dbSNP
rs542956244 666 dbSNP
rs1160375670 670 dbSNP
rs976913962 680 dbSNP
rs961568122 683 dbSNP
rs908777209 689 dbSNP
rs1173480320 699 dbSNP
rs529235804 702 dbSNP
rs1448103827 713 dbSNP
rs560142001 719 dbSNP
rs116555471 720 dbSNP
rs1288768753 726 dbSNP
rs76524606 727 dbSNP
rs1012913451 736 dbSNP
rs960108886 740 dbSNP
rs1214724258 745 dbSNP
rs1035771122 747 dbSNP
rs1003318240 749 dbSNP
rs1286853248 759 dbSNP
rs572623510 769 dbSNP
rs919910448 774 dbSNP
rs902368073 779 dbSNP
rs1341249 785 dbSNP
rs1254467514 789 dbSNP
rs1304022052 791 dbSNP
rs962270104 798 dbSNP
rs1014797162 806 dbSNP
rs1220234515 809 dbSNP
rs1003336490 813 dbSNP
rs970493350 824 dbSNP
rs545184602 829 dbSNP
rs368808370 833 dbSNP
rs1368104247 844 dbSNP
rs1340293366 846 dbSNP
rs1429081073 857 dbSNP
rs758371957 859 dbSNP
rs893433907 862 dbSNP
rs576342726 864 dbSNP
rs1023357766 874 dbSNP
rs1011921912 877 dbSNP
rs556479360 878 dbSNP
rs1273971860 881 dbSNP
rs1368581218 882 dbSNP
rs1221115975 884 dbSNP
rs752830233 889 dbSNP
rs1341519212 891 dbSNP
rs1206585111 894 dbSNP
rs1277379297 894 dbSNP
rs1489986060 897 dbSNP
rs1221298480 901 dbSNP
rs1247612505 904 dbSNP
rs1276634941 909 dbSNP
rs779189931 916 dbSNP
rs1387830730 930 dbSNP
rs1360725123 932 dbSNP
rs1169210610 936 dbSNP
rs536575409 941 dbSNP
rs1403472360 953 dbSNP
rs573654146 954 dbSNP
rs1322686788 963 dbSNP
rs932342468 976 dbSNP
rs553821594 982 dbSNP
rs1040841898 986 dbSNP
rs902755641 996 dbSNP
rs575823609 999 dbSNP
rs1229246887 1018 dbSNP
rs1299828468 1021 dbSNP
rs1360879282 1022 dbSNP
rs940148783 1024 dbSNP
rs151188261 1025 dbSNP
rs767396925 1038 dbSNP
rs1453650321 1041 dbSNP
rs778237151 1044 dbSNP
rs1215254248 1047 dbSNP
rs1245807186 1048 dbSNP
rs1464119234 1049 dbSNP
rs1421231765 1068 dbSNP
rs984354495 1074 dbSNP
rs953076551 1076 dbSNP
rs1391440706 1079 dbSNP
rs1471783387 1080 dbSNP
rs1162564014 1083 dbSNP
rs1264135360 1086 dbSNP
rs916202853 1087 dbSNP
rs571324394 1095 dbSNP
rs889931080 1098 dbSNP
rs551235229 1099 dbSNP
rs538425381 1112 dbSNP
rs113992447 1124 dbSNP
rs751128995 1125 dbSNP
rs1338750599 1126 dbSNP
rs1035717305 1135 dbSNP
rs1285302270 1143 dbSNP
rs1358980792 1144 dbSNP
rs1226961390 1149 dbSNP
rs866190505 1151 dbSNP
rs1267828244 1157 dbSNP
rs1328087057 1167 dbSNP
rs549244566 1176 dbSNP
rs1211453829 1183 dbSNP
rs1317793690 1196 dbSNP
rs1263284049 1198 dbSNP
rs998913693 1202 dbSNP
rs186995866 1204 dbSNP
rs77061845 1210 dbSNP
rs1010779645 1215 dbSNP
rs893707789 1234 dbSNP
rs546975329 1236 dbSNP
rs1400237948 1238 dbSNP
rs1413967989 1248 dbSNP
rs907784100 1248 dbSNP
rs1342790069 1249 dbSNP
rs1408499938 1258 dbSNP
rs1288142717 1261 dbSNP
rs762308501 1267 dbSNP
rs981969601 1269 dbSNP
rs1228670415 1272 dbSNP
rs1262119652 1273 dbSNP
rs970545751 1274 dbSNP
rs182715008 1284 dbSNP
rs190503314 1285 dbSNP
rs958024368 1286 dbSNP
rs1179893440 1287 dbSNP
rs1250847075 1289 dbSNP
rs544412021 1310 dbSNP
rs1397978427 1315 dbSNP
rs1172609595 1317 dbSNP
rs779192109 1320 dbSNP
rs576280132 1321 dbSNP
rs908668808 1325 dbSNP
rs1465674941 1326 dbSNP
rs375570695 1326 dbSNP
rs1173268813 1330 dbSNP
rs1404385323 1336 dbSNP
rs1428440546 1337 dbSNP
rs1307926590 1340 dbSNP
rs1187102811 1345 dbSNP
rs1412077858 1356 dbSNP
rs1299560694 1368 dbSNP
rs1329024207 1370 dbSNP
rs1232012706 1371 dbSNP
rs760009773 1378 dbSNP
rs1349376490 1384 dbSNP
rs1203013673 1386 dbSNP
rs560437899 1387 dbSNP
rs1020300397 1388 dbSNP
rs1008472307 1395 dbSNP
rs1264956014 1404 dbSNP
rs1432847005 1411 dbSNP
rs756232450 1414 dbSNP
rs61822590 1418 dbSNP
rs931531308 1419 dbSNP
rs1168577696 1421 dbSNP
rs916149854 1428 dbSNP
rs1319026394 1430 dbSNP
rs898585224 1437 dbSNP
rs1292167732 1438 dbSNP
rs1390436124 1439 dbSNP
rs1265156254 1441 dbSNP
rs1323802316 1447 dbSNP
rs61822589 1448 dbSNP
rs547623924 1453 dbSNP
rs1296147219 1454 dbSNP
rs148674045 1455 dbSNP
rs533781823 1457 dbSNP
rs1229460459 1461 dbSNP
rs1772159 1466 dbSNP
rs757144571 1467 dbSNP
rs772353733 1477 dbSNP
rs1210732483 1478 dbSNP
rs977437714 1480 dbSNP
rs967865646 1481 dbSNP
rs1188039361 1485 dbSNP
rs1248668837 1497 dbSNP
rs751377309 1501 dbSNP
rs1430858855 1503 dbSNP
rs557819447 1503 dbSNP
rs989708452 1505 dbSNP
rs1447330684 1514 dbSNP
rs957923408 1519 dbSNP
rs1028221615 1520 dbSNP
rs186856632 1527 dbSNP
rs1161191764 1539 dbSNP
rs183993152 1542 dbSNP
rs1432394197 1544 dbSNP
rs957862391 1558 dbSNP
rs549174994 1561 dbSNP
rs535704227 1569 dbSNP
rs1310480134 1581 dbSNP
rs1003920208 1597 dbSNP
rs192094081 1598 dbSNP
rs755157526 1605 dbSNP
rs1208321479 1607 dbSNP
rs1248766508 1608 dbSNP
rs750336222 1608 dbSNP
rs1256083391 1611 dbSNP
rs894663997 1618 dbSNP
rs1424840216 1620 dbSNP
rs1190555220 1633 dbSNP
rs1019273193 1645 dbSNP
rs1055942788 1655 dbSNP
rs1208394988 1657 dbSNP
rs938940835 1659 dbSNP
rs762589566 1661 dbSNP
rs1454884133 1668 dbSNP
rs1300509310 1684 dbSNP
rs1378388451 1686 dbSNP
rs928931376 1692 dbSNP
rs977817699 1698 dbSNP
rs1292025488 1699 dbSNP
rs762962201 1704 dbSNP
rs1294954576 1721 dbSNP
rs1348359732 1727 dbSNP
rs371461733 1729 dbSNP
rs1228083605 1730 dbSNP
rs946098002 1735 dbSNP
rs1268989620 1738 dbSNP
rs914624420 1739 dbSNP
rs1350858992 1740 dbSNP
rs76710847 1744 dbSNP
rs890035981 1760 dbSNP
rs1240806301 1766 dbSNP
rs1213623490 1775 dbSNP
rs957830242 1777 dbSNP
rs1028170666 1778 dbSNP
rs1250119501 1787 dbSNP
rs1330407482 1790 dbSNP
rs531284023 1796 dbSNP
rs975287421 1799 dbSNP
rs1321386922 1808 dbSNP
rs1408287173 1813 dbSNP
rs1388272158 1824 dbSNP
rs1420437879 1825 dbSNP
rs1173370630 1831 dbSNP
rs1393217050 1834 dbSNP
rs1435308852 1841 dbSNP
rs1314641496 1843 dbSNP
rs556083997 1847 dbSNP
rs781217016 1848 dbSNP
rs533342852 1879 dbSNP
rs886800941 1880 dbSNP
rs1375834209 1883 dbSNP
rs1300741545 1889 dbSNP
rs1348649576 1893 dbSNP
rs1027126730 1904 dbSNP
rs1037534020 1913 dbSNP
rs564349299 1917 dbSNP
rs373916268 1946 dbSNP
rs1206322947 1953 dbSNP
rs1234908039 1956 dbSNP
rs551023794 1962 dbSNP
rs1004285322 1964 dbSNP
rs186068484 1979 dbSNP
rs562636256 1982 dbSNP
rs1377533421 1983 dbSNP
rs1388252292 1984 dbSNP
rs1428979132 1993 dbSNP
rs1045704707 1994 dbSNP
rs1356043057 1998 dbSNP
rs1434638308 1999 dbSNP
rs752356341 1999 dbSNP
rs1055887556 2004 dbSNP
rs938888438 2005 dbSNP
rs78159487 2013 dbSNP
rs916504573 2020 dbSNP
rs1215643913 2023 dbSNP
rs1275597223 2042 dbSNP
rs1041998302 2055 dbSNP
rs1320288741 2060 dbSNP
rs1269241024 2067 dbSNP
rs751380021 2068 dbSNP
rs377458082 2069 dbSNP
rs1219001918 2072 dbSNP
rs1245781353 2076 dbSNP
rs946017426 2077 dbSNP
rs1215450325 2084 dbSNP
rs914592848 2085 dbSNP
rs759015267 2090 dbSNP
rs1245611166 2102 dbSNP
rs1054942838 2104 dbSNP
rs1054915656 2109 dbSNP
rs1205171346 2110 dbSNP
rs1421480928 2111 dbSNP
rs932054670 2113 dbSNP
rs1344282085 2116 dbSNP
rs1403379424 2122 dbSNP
rs936514834 2122 dbSNP
rs1395501377 2126 dbSNP
rs74336727 2128 dbSNP
rs1331474493 2152 dbSNP
rs1318675621 2167 dbSNP
rs978270302 2177 dbSNP
rs1432194224 2183 dbSNP
rs975233309 2184 dbSNP
rs965233673 2196 dbSNP
rs545204148 2199 dbSNP
rs540194342 2201 dbSNP
rs982738518 2205 dbSNP
rs1335098311 2207 dbSNP
rs953657094 2208 dbSNP
rs1300163442 2218 dbSNP
rs144174912 2232 dbSNP
rs1026657999 2233 dbSNP
rs35360476 2236 dbSNP
rs963231483 2247 dbSNP
rs139046521 2255 dbSNP
rs1171334808 2256 dbSNP
rs1418246559 2260 dbSNP
rs958442339 2260 dbSNP
rs1479252668 2272 dbSNP
rs1388069980 2290 dbSNP
rs758067912 2302 dbSNP
rs1430446318 2306 dbSNP
rs907288104 2315 dbSNP
rs1002978269 2316 dbSNP
rs1476658666 2319 dbSNP
rs1264851269 2324 dbSNP
rs907401067 2337 dbSNP
rs1042336152 2338 dbSNP
rs1193349543 2340 dbSNP
rs1234827108 2340 dbSNP
rs1286061039 2347 dbSNP
rs542245704 2348 dbSNP
rs764708812 2360 dbSNP
rs879443957 2369 dbSNP
rs574998066 2377 dbSNP
rs932002341 2385 dbSNP
rs1440654409 2391 dbSNP
rs921996034 2392 dbSNP
rs867871756 2396 dbSNP
rs1275809099 2399 dbSNP
rs1202117591 2403 dbSNP
rs1324117440 2404 dbSNP
rs759069666 2409 dbSNP
rs777082500 2415 dbSNP
rs555088150 2418 dbSNP
rs1216539333 2419 dbSNP
rs971623926 2424 dbSNP
rs535642573 2429 dbSNP
rs912410758 2430 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000367137.3 | 3UTR | GAAAGAAAAUGAAGGUGACUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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