pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLC38A7   
Synonyms SNAT7
Description solute carrier family 38 member 7
Transcript NM_018231   
Expression
Putative miRNA Targets on SLC38A7
3'UTR of SLC38A7
(miRNA target sites are highlighted)
>SLC38A7|NM_018231|3'UTR
   1 CCACTGCCTCCCAGGGAACACAAGGCCTTTGCCATTGGTCGCAGGAACCCATCTCTTAGAGCTATGGGGCCATTCTTAGT
  81 CCACGATCATTCCAACTGGTGGGATGACATCCGGACATCCTCTTCCAGGGACTGGGGCAAACTCAGGCCCCACACCTCTG
 161 GACAGCTCAAATCCAGTCCCCTTCCTGCTCCCCAGTCCTGGCAGTGCCGTGGATGGCGGCAGGAAGTCTCACATCATAGA
 241 GGACCCCTCCTCCTCTCCCAGTTCTCAACTTCTCCATGCCTGGAATCCACGGGTGAAGAGAGTCGGTAGATCTCATAAGA
 321 AAGAATCCAGTCTGACTTCCCTCTGGAGAATGACTATGGACAGAAGGCCACCATCCTCCACAGAGCACCCTGTCCTGAGT
 401 AGGGGTTGTGCTCATTACCCCAGGCCAGTGGTAGCTTCCTCAGGAGCCTGGCCACTTCCAACGGTAGCACTGAAGTCATG
 481 CAAATGCATAGTCAGGTAGATTCAGACCTTGTCCACACCTTCCTGGGCAACCCCCACCATGAACCTGTCAGCCTCTTTCC
 561 CATAGCTAATAGACATTTCCCAGGCCTTGAGGGGCCCCACCCTGTCTCTTTCATCAAACCTGATGGTCCAGGCTGGGCAT
 641 CCCTCTCCTCCTCCATCCCCAGACATCACCAGGTCTAATGTTTACAAACGGTGCCAGCCCGGCTCTGAAGCCAAGGGCCG
 721 TCCCGTGCCACGGTGCTGTGAGTATTCCTCCGTTAGCTTTCCCCATAAGGTTGGGAGTATCTGCTTTTGTGTCTGAGATG
 801 GGCCCCTCTTTTCAGAGGCCGCAGGGTGGGTGATGGAGAAGGCTGAGAACCTTTCAGACCCTCTGTGTGGGCTGGGCTGG
 881 TCAGAATCAGGGTGTACCTCCCCGACACCTTCTTTTTCAGTGATGTTTTCTCTTCTTCCTGCCTTTCCTCTGCCTCCTCC
 961 CCTGCCAGCCCTAGCGTGACTACCCAGAGACAAAAAAAAAAAAAAAAAAAAAAGGCAGGGCTGGGCGCAGTGGCTCACGC
1041 CTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGATGACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACACGG
1121 CAAAACCCCATCTCTACTAAAAATACAAAAAATTAACCGGGCATGGTGGCGGGCACCTGTAATCCCAGCTACTTGGGAGG
1201 CTGAGGCAGCAGAGCCGCTTAAACCCAGGAGGCAGAGACTGCAATGAGCTGAGATCGTGCCATTGCACTCCAGCTTGGGC
1281 AACAAGAGTGAAACTTCATCTCAAAAAAACAGAAACAAACAAAAAGGCAGCTGGGTTGTCACTGATGGGCAGCATTTGAG
1361 CCTGCCACACTGGCCTGGAAGTTTCCCTTCCAGTCTGGATTTTGTCTGCTCCTTCCTTCCCCCTCACCCCGTTACCTCTT
1441 CACCTCCCATCTCACTTCACTGTGTAGCTCAGTCTCTCCCACGCACATAATTGGGGACAGTGGGGGCTCTCTTACCAGCC
1521 TCCTCAGCAACGCACGTCCATCAGGCCTGGCCTCAGTGGCCAGCCACATTGATGTCACACTGGAATTGTTACCCCAGAGA
1601 GGGCGAAGAGATAGGCTATCTCCCCACCTCCCACCCTACTCCCCACTATATTCCCGTTTTGACCACCTCAGCCCCTCAGC
1681 TGCCCCCTCTCACTTTGGCCAATCCCAGGCACCAATCAGACTTCCTCCTCCACCTGGAGCCCCTAGCATTTCCTTGTCCC
1761 CTCTTCCCCAAAACCTCTGTAAAGGGTACGAGAGGGACCCCCTGCCGAGCCGCCCGCCACTCAGGGCAGTCCGATCTAAG
1841 AAGCAGAAGCTGGTTGGAGGCTGGCTGGGCCTCTGTCCAGTCCCCAGATGGATAAACTGCCTTTTCTCACATCCCCTCTT
1921 GGTGCCTGATCTTCTCTGCCCCCGGGGCCAGACCCACTGTGCTGTTTTCTGTCAGTCTGTGGCACAGCACCAAGCTCTGC
2001 CAGCACCAGTCCCTGACAGGGCTAGGAGGACAGCCTGGTCAGCAGGGCTGCAGTCCCCCAGTGCCGTGTTTCGGGGGTCA
2081 AGGGATGTAAGTGGAGTCATTGCACAGAGACAGACCAGTCAGGAGAAGGAGCTGGAATCTGGCCTCTTGTCCTAACCTCA
2161 GGAGCCCCCTCCCATCCTCTCCCCACCCTCCCTATCGGGGTACTTCACTGTTTCTTTTCTACTTGTGTATACTCGAGAAA
2241 GGGAAGATGGTTAATAAAAGGGATTTGTGCTGCTGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucGACAAGGACGACUu 5'
            :|| | ||||||| 
Target 5' atTTG-TGCTGCTGA- 3'
2263 - 2276 145.00 -11.20
2
miRNA  3' ucgacAAGGACGAcuu 5'
               ||||||||   
Target 5' tccccTTCCTGCTccc 3'
177 - 192 115.00 -9.02
3
miRNA  3' ucgacaaGGACGACUu 5'
                 ||||| || 
Target 5' gggacccCCTGCCGAg 3'
1794 - 1809 113.00 -8.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30475098 10 COSMIC
COSN30728535 14 COSMIC
COSN19750659 23 COSMIC
COSN24872557 34 COSMIC
COSN30496339 40 COSMIC
COSN31541964 44 COSMIC
COSN26635082 62 COSMIC
COSN31517219 75 COSMIC
COSN30152449 76 COSMIC
COSN30530161 84 COSMIC
COSN30165813 99 COSMIC
COSN30533421 113 COSMIC
COSN31520050 656 COSMIC
COSN29116067 720 COSMIC
COSN31562018 767 COSMIC
COSN31551208 781 COSMIC
COSN6087872 1035 COSMIC
COSN6087871 1042 COSMIC
COSN6087870 1083 COSMIC
COSN8234262 1345 COSMIC
COSN7262210 1351 COSMIC
COSN32065550 1597 COSMIC
COSN32065235 1605 COSMIC
COSN21502771 1734 COSMIC
COSN17491074 1797 COSMIC
COSN19741440 1812 COSMIC
COSN1188520 1856 COSMIC
COSN32064357 1882 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1291367753 2 dbSNP
rs757387507 5 dbSNP
rs1422749811 8 dbSNP
rs1046183241 12 dbSNP
rs747105214 14 dbSNP
rs1460460098 18 dbSNP
rs777648494 19 dbSNP
rs1422767896 24 dbSNP
rs1194337966 25 dbSNP
rs1400781928 30 dbSNP
rs369506296 31 dbSNP
rs1448638567 34 dbSNP
rs1265017866 40 dbSNP
rs377338753 41 dbSNP
rs1488926330 45 dbSNP
rs1404280413 49 dbSNP
rs918961779 51 dbSNP
rs1378662485 58 dbSNP
rs1396805141 61 dbSNP
rs916275983 64 dbSNP
rs1196803711 66 dbSNP
rs372988602 68 dbSNP
rs779432472 69 dbSNP
rs539052273 70 dbSNP
rs765680985 71 dbSNP
rs1221013492 74 dbSNP
rs755361903 75 dbSNP
rs189625164 79 dbSNP
rs766114265 82 dbSNP
rs755459159 84 dbSNP
rs1327522985 85 dbSNP
rs1463566606 89 dbSNP
rs746566255 95 dbSNP
rs772849383 95 dbSNP
rs369443312 97 dbSNP
rs12447480 100 dbSNP
rs779741765 101 dbSNP
rs774128053 112 dbSNP
rs768565238 113 dbSNP
rs749071649 114 dbSNP
rs907667781 119 dbSNP
rs775209639 124 dbSNP
rs1457323994 126 dbSNP
rs754195568 128 dbSNP
rs1171049106 147 dbSNP
rs150400130 149 dbSNP
rs941965850 153 dbSNP
rs954608223 156 dbSNP
rs1426160255 164 dbSNP
rs1030154919 173 dbSNP
rs1192864576 177 dbSNP
rs910489632 179 dbSNP
rs568540637 180 dbSNP
rs766851321 184 dbSNP
rs1467015708 187 dbSNP
rs77543879 188 dbSNP
rs954575451 194 dbSNP
rs1466804288 198 dbSNP
rs558720388 201 dbSNP
rs976843946 208 dbSNP
rs377144499 209 dbSNP
rs1279412270 210 dbSNP
rs1011132029 214 dbSNP
rs894069477 217 dbSNP
rs1020937730 218 dbSNP
rs1276621172 221 dbSNP
rs1031128783 230 dbSNP
rs1210401648 232 dbSNP
rs1000099399 233 dbSNP
rs1484625705 236 dbSNP
rs906736538 243 dbSNP
rs1306916387 244 dbSNP
rs1010886259 245 dbSNP
rs372283137 247 dbSNP
rs1424277673 250 dbSNP
rs1388350481 252 dbSNP
rs1433498621 255 dbSNP
rs947825028 263 dbSNP
rs1343602213 264 dbSNP
rs1419301085 267 dbSNP
rs1302170955 268 dbSNP
rs894786428 287 dbSNP
rs1037338486 291 dbSNP
rs1403699622 293 dbSNP
rs1002831268 294 dbSNP
rs748508714 297 dbSNP
rs941914720 298 dbSNP
rs906741326 302 dbSNP
rs1302985971 303 dbSNP
rs907782573 304 dbSNP
rs1238935296 308 dbSNP
rs1286198846 308 dbSNP
rs1046595125 309 dbSNP
rs993275445 310 dbSNP
rs983423725 315 dbSNP
rs1192751782 321 dbSNP
rs761186846 322 dbSNP
rs1439391388 323 dbSNP
rs1159459283 341 dbSNP
rs113411129 342 dbSNP
rs571133332 348 dbSNP
rs1462930598 361 dbSNP
rs1373054242 362 dbSNP
rs143050050 367 dbSNP
rs1435313991 380 dbSNP
rs1350928754 390 dbSNP
rs115724372 397 dbSNP
rs964135080 398 dbSNP
rs1018252861 404 dbSNP
rs563737581 405 dbSNP
rs1445663346 407 dbSNP
rs1489861842 412 dbSNP
rs1050366749 413 dbSNP
rs750659058 418 dbSNP
rs1206033810 423 dbSNP
rs1226067480 430 dbSNP
rs1355237687 430 dbSNP
rs933235845 434 dbSNP
rs767681829 438 dbSNP
rs548683361 439 dbSNP
rs530243929 447 dbSNP
rs561727801 454 dbSNP
rs879206479 461 dbSNP
rs4784965 462 dbSNP
rs11860249 475 dbSNP
rs1457108366 478 dbSNP
rs4784964 486 dbSNP
rs1240217446 487 dbSNP
rs1442882142 491 dbSNP
rs1282169817 496 dbSNP
rs1414588588 498 dbSNP
rs1407640829 503 dbSNP
rs1168942693 504 dbSNP
rs914004299 518 dbSNP
rs989941430 524 dbSNP
rs1331658821 526 dbSNP
rs1378715496 530 dbSNP
rs867165164 531 dbSNP
rs958069284 533 dbSNP
rs1379246650 540 dbSNP
rs1221297826 547 dbSNP
rs1229971842 550 dbSNP
rs1025112160 559 dbSNP
rs1034096295 560 dbSNP
rs1011918638 575 dbSNP
rs894902542 576 dbSNP
rs112428565 593 dbSNP
rs185606330 596 dbSNP
rs1396360934 599 dbSNP
rs886136683 601 dbSNP
rs1238186672 628 dbSNP
rs1048090338 633 dbSNP
rs1473787012 649 dbSNP
rs933268201 651 dbSNP
rs1016024231 655 dbSNP
rs1173322494 657 dbSNP
rs1006344363 659 dbSNP
rs1412456445 679 dbSNP
rs888825771 683 dbSNP
rs762805484 687 dbSNP
rs754336462 689 dbSNP
rs1449530139 695 dbSNP
rs1276251501 698 dbSNP
rs1339817742 700 dbSNP
rs1176244625 701 dbSNP
rs1479571585 710 dbSNP
rs1050506349 714 dbSNP
rs933268331 719 dbSNP
rs775473918 720 dbSNP
rs1214484207 721 dbSNP
rs942721284 724 dbSNP
rs369531179 725 dbSNP
rs914354746 727 dbSNP
rs780772844 731 dbSNP
rs769567085 732 dbSNP
rs989597847 733 dbSNP
rs958265696 735 dbSNP
rs936746128 739 dbSNP
rs1171668935 744 dbSNP
rs1425374238 747 dbSNP
rs1415800122 748 dbSNP
rs1295856780 751 dbSNP
rs181246914 752 dbSNP
rs554758755 752 dbSNP
rs375066153 756 dbSNP
rs1025245236 758 dbSNP
rs368669763 761 dbSNP
rs538230050 761 dbSNP
rs574880588 763 dbSNP
rs971011647 764 dbSNP
rs1016840486 773 dbSNP
rs1025059695 774 dbSNP
rs1288619099 775 dbSNP
rs763635054 779 dbSNP
rs1006003861 782 dbSNP
rs1012368519 787 dbSNP
rs888849063 792 dbSNP
rs1488623142 800 dbSNP
rs1028678997 802 dbSNP
rs745714228 805 dbSNP
rs1333494484 806 dbSNP
rs1451413679 807 dbSNP
rs1305413793 815 dbSNP
rs1379704405 820 dbSNP
rs556568729 821 dbSNP
rs80310996 822 dbSNP
rs1041622216 823 dbSNP
rs1419707459 826 dbSNP
rs780795665 827 dbSNP
rs1388430828 832 dbSNP
rs117468659 834 dbSNP
rs997807357 836 dbSNP
rs796923927 837 dbSNP
rs1444852155 838 dbSNP
rs893005360 841 dbSNP
rs1054685352 843 dbSNP
rs770517500 844 dbSNP
rs1242343571 855 dbSNP
rs1263735055 874 dbSNP
rs1356312912 876 dbSNP
rs936796435 891 dbSNP
rs1269990971 894 dbSNP
rs1039007285 903 dbSNP
rs367779520 904 dbSNP
rs8074 912 dbSNP
rs1237153455 915 dbSNP
rs535222500 924 dbSNP
rs12696 937 dbSNP
rs1362130765 942 dbSNP
rs1189775334 946 dbSNP
rs917885961 954 dbSNP
rs1163707843 955 dbSNP
rs1396411931 958 dbSNP
rs552917958 962 dbSNP
rs371660051 963 dbSNP
rs1242494819 975 dbSNP
rs1181478374 976 dbSNP
rs1466107003 985 dbSNP
rs1284452286 987 dbSNP
rs1204194206 989 dbSNP
rs1348187065 991 dbSNP
rs1266685958 992 dbSNP
rs1244945934 993 dbSNP
rs1246183846 993 dbSNP
rs1384146375 1004 dbSNP
rs1315007483 1005 dbSNP
rs936788303 1005 dbSNP
rs1450834062 1006 dbSNP
rs1367798079 1008 dbSNP
rs1319469883 1009 dbSNP
rs1381849111 1011 dbSNP
rs1198357400 1013 dbSNP
rs1178560374 1014 dbSNP
rs1188197753 1014 dbSNP
rs1253477545 1014 dbSNP
rs1260827322 1014 dbSNP
rs1396642723 1014 dbSNP
rs1400755232 1014 dbSNP
rs1419879436 1014 dbSNP
rs1422657696 1014 dbSNP
rs1457968085 1014 dbSNP
rs1476787481 1014 dbSNP
rs5817157 1014 dbSNP
rs760656023 1014 dbSNP
rs760872724 1014 dbSNP
rs869165322 1014 dbSNP
rs923904081 1014 dbSNP
rs1295682956 1020 dbSNP
rs1383133854 1021 dbSNP
rs1218533899 1022 dbSNP
rs1165040905 1026 dbSNP
rs1425413932 1027 dbSNP
rs188426281 1036 dbSNP
rs971175639 1038 dbSNP
rs918162181 1039 dbSNP
rs991062272 1055 dbSNP
rs1200583711 1067 dbSNP
rs570041893 1071 dbSNP
rs139125379 1072 dbSNP
rs1444902163 1080 dbSNP
rs764946803 1090 dbSNP
rs1006352754 1096 dbSNP
rs950501525 1098 dbSNP
rs1486982655 1099 dbSNP
rs184332916 1099 dbSNP
rs181628771 1107 dbSNP
rs146582259 1118 dbSNP
rs1038955111 1129 dbSNP
rs1217781490 1146 dbSNP
rs1029170147 1153 dbSNP
rs1300990767 1153 dbSNP
rs1271113666 1158 dbSNP
rs1227200787 1159 dbSNP
rs1007504261 1161 dbSNP
rs528306751 1163 dbSNP
rs375374917 1169 dbSNP
rs1263763392 1170 dbSNP
rs545672490 1171 dbSNP
rs1189305227 1184 dbSNP
rs1266379113 1185 dbSNP
rs754390078 1187 dbSNP
rs1175693328 1192 dbSNP
rs1378551005 1198 dbSNP
rs1419125879 1199 dbSNP
rs1042902440 1202 dbSNP
rs1159806118 1206 dbSNP
rs949401290 1212 dbSNP
rs917942354 1216 dbSNP
rs141305870 1217 dbSNP
rs959630369 1221 dbSNP
rs1293377022 1224 dbSNP
rs756524391 1227 dbSNP
rs1420199772 1232 dbSNP
rs1368731770 1239 dbSNP
rs1441197606 1256 dbSNP
rs138834186 1257 dbSNP
rs984976914 1262 dbSNP
rs1350907225 1279 dbSNP
rs541435031 1304 dbSNP
rs377552541 1312 dbSNP
rs1378954545 1314 dbSNP
rs1199701605 1324 dbSNP
rs1490103112 1326 dbSNP
rs1219281948 1333 dbSNP
rs1264704589 1344 dbSNP
rs1266133893 1346 dbSNP
rs553053440 1351 dbSNP
rs1439291219 1353 dbSNP
rs1206741644 1358 dbSNP
rs1410243759 1359 dbSNP
rs143164384 1361 dbSNP
rs1164620466 1370 dbSNP
rs1350839304 1376 dbSNP
rs1463308076 1378 dbSNP
rs905663706 1385 dbSNP
rs976267040 1389 dbSNP
rs750857280 1394 dbSNP
rs1017300052 1399 dbSNP
rs1274355625 1406 dbSNP
rs577352211 1423 dbSNP
rs893060744 1430 dbSNP
rs149110206 1431 dbSNP
rs917956561 1434 dbSNP
rs998690209 1441 dbSNP
rs1335258225 1447 dbSNP
rs1215383454 1453 dbSNP
rs154470 1455 dbSNP
rs940976465 1456 dbSNP
rs909471530 1472 dbSNP
rs1234685927 1474 dbSNP
rs570400115 1482 dbSNP
rs1281434826 1483 dbSNP
rs190539603 1491 dbSNP
rs1444508244 1495 dbSNP
rs1354999175 1497 dbSNP
rs1400025422 1501 dbSNP
rs185608212 1501 dbSNP
rs1329051790 1506 dbSNP
rs1407948325 1515 dbSNP
rs1404078876 1518 dbSNP
rs1055058861 1525 dbSNP
rs566009397 1528 dbSNP
rs975839820 1530 dbSNP
rs938228803 1531 dbSNP
rs909465928 1532 dbSNP
rs985481166 1535 dbSNP
rs547855758 1536 dbSNP
rs375015831 1556 dbSNP
rs1209570224 1572 dbSNP
rs1258282206 1580 dbSNP
rs1019933674 1584 dbSNP
rs1010337660 1592 dbSNP
rs1475920912 1594 dbSNP
rs30822 1599 dbSNP
rs1412366878 1601 dbSNP
rs1233902980 1602 dbSNP
rs763081862 1604 dbSNP
rs1375505287 1606 dbSNP
rs1416556937 1612 dbSNP
rs1296195188 1627 dbSNP
rs1436649155 1632 dbSNP
rs1033350540 1634 dbSNP
rs1343190117 1638 dbSNP
rs1204770837 1640 dbSNP
rs1001420860 1641 dbSNP
rs905732818 1648 dbSNP
rs1323053343 1650 dbSNP
rs1261534974 1655 dbSNP
rs1045581885 1656 dbSNP
rs117928758 1665 dbSNP
rs896553748 1667 dbSNP
rs1374167232 1679 dbSNP
rs536881346 1683 dbSNP
rs1279105601 1686 dbSNP
rs1439916302 1687 dbSNP
rs775386060 1700 dbSNP
rs760649071 1702 dbSNP
rs1172566024 1704 dbSNP
rs1395163590 1706 dbSNP
rs1337113150 1709 dbSNP
rs1435996988 1714 dbSNP
rs765203161 1725 dbSNP
rs1359878848 1726 dbSNP
rs940697385 1731 dbSNP
rs759290422 1732 dbSNP
rs530676561 1735 dbSNP
rs1049779327 1736 dbSNP
rs1436049597 1737 dbSNP
rs1304362423 1747 dbSNP
rs999201185 1752 dbSNP
rs932248471 1756 dbSNP
rs531850528 1761 dbSNP
rs1352116311 1763 dbSNP
rs1175035385 1767 dbSNP
rs922134276 1772 dbSNP
rs1451326907 1777 dbSNP
rs902990410 1778 dbSNP
rs1469037259 1787 dbSNP
rs1024570033 1789 dbSNP
rs1013587451 1790 dbSNP
rs1362705435 1791 dbSNP
rs1454301946 1794 dbSNP
rs1184550071 1796 dbSNP
rs935502795 1797 dbSNP
rs1160171384 1799 dbSNP
rs145080798 1803 dbSNP
rs912996557 1804 dbSNP
rs561187769 1806 dbSNP
rs80327081 1807 dbSNP
rs938007486 1810 dbSNP
rs1218220799 1811 dbSNP
rs980460027 1812 dbSNP
rs887806099 1815 dbSNP
rs373696603 1816 dbSNP
rs1356119455 1820 dbSNP
rs1361455214 1824 dbSNP
rs1214762181 1830 dbSNP
rs559117980 1831 dbSNP
rs919404997 1832 dbSNP
rs976256077 1833 dbSNP
rs944896003 1849 dbSNP
rs541098722 1853 dbSNP
rs910295381 1854 dbSNP
rs1249228688 1856 dbSNP
rs1451567520 1857 dbSNP
rs1419085243 1863 dbSNP
rs985905685 1866 dbSNP
rs957041658 1868 dbSNP
rs1366692860 1878 dbSNP
rs1380309645 1882 dbSNP
rs1014114986 1883 dbSNP
rs1474819858 1887 dbSNP
rs925626094 1898 dbSNP
rs527885781 1908 dbSNP
rs967705486 1913 dbSNP
rs866355000 1916 dbSNP
rs62065309 1924 dbSNP
rs572802649 1928 dbSNP
rs1393162589 1934 dbSNP
rs1332247556 1936 dbSNP
rs149871814 1943 dbSNP
rs1295564516 1944 dbSNP
rs958567979 1944 dbSNP
rs1316389394 1950 dbSNP
rs1216420310 1952 dbSNP
rs544037902 1954 dbSNP
rs1250376779 1959 dbSNP
rs1480688693 1960 dbSNP
rs887814174 1962 dbSNP
rs1387578202 1973 dbSNP
rs1033713910 1974 dbSNP
rs1253452891 1978 dbSNP
rs1485335567 1988 dbSNP
rs1164788864 1990 dbSNP
rs1188494190 1991 dbSNP
rs1419765320 1995 dbSNP
rs576760282 1998 dbSNP
rs1170035151 1999 dbSNP
rs1373904214 2010 dbSNP
rs1463693462 2019 dbSNP
rs1444322110 2035 dbSNP
rs1241667592 2043 dbSNP
rs1188707887 2047 dbSNP
rs1002269237 2052 dbSNP
rs1315279612 2056 dbSNP
rs900783683 2062 dbSNP
rs1241775762 2065 dbSNP
rs780258329 2066 dbSNP
rs1296694567 2072 dbSNP
rs186864743 2073 dbSNP
rs1049542862 2075 dbSNP
rs993731228 2077 dbSNP
rs1253752378 2080 dbSNP
rs536580745 2081 dbSNP
rs1245144569 2083 dbSNP
rs369396588 2103 dbSNP
rs1259464801 2107 dbSNP
rs1040682493 2111 dbSNP
rs944842729 2123 dbSNP
rs925637496 2124 dbSNP
rs979773430 2135 dbSNP
rs969688695 2144 dbSNP
rs1394568191 2146 dbSNP
rs183690971 2147 dbSNP
rs1050147707 2149 dbSNP
rs1359225035 2156 dbSNP
rs935760298 2157 dbSNP
rs1406185814 2161 dbSNP
rs925605142 2168 dbSNP
rs578242740 2184 dbSNP
rs780675535 2190 dbSNP
rs1424556812 2196 dbSNP
rs1005410331 2197 dbSNP
rs1172936294 2200 dbSNP
rs756720369 2202 dbSNP
rs1214977057 2204 dbSNP
rs1028132746 2209 dbSNP
rs1418996247 2214 dbSNP
rs996148332 2222 dbSNP
rs117711557 2227 dbSNP
rs917158561 2229 dbSNP
rs1189715659 2231 dbSNP
rs1490920464 2232 dbSNP
rs140251526 2234 dbSNP
rs958515608 2235 dbSNP
rs1454847038 2264 dbSNP
rs1195645284 2270 dbSNP
rs944958423 2274 dbSNP
rs3179798 2275 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucgacaaggACGACUu 5'
                   |||||| 
Target 5' ---------UGCUGAa 3'
1 - 7
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000570101.1 | 3UTR | UGCUGAAACCCUGUCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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