pre-miRNA Information
pre-miRNA hsa-mir-4419b   
Genomic Coordinates chr12: 128244506 - 128244573
Description Homo sapiens miR-4419b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4419b
Sequence 42| GAGGCUGAAGGAAGAUGG |59
Evidence Experimental
Experiments Illumina
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SHOC2   
Synonyms SIAA0862, SOC2, SUR8
Description SHOC2, leucine rich repeat scaffold protein
Transcript NM_007373   
Expression
Putative miRNA Targets on SHOC2
3'UTR of SHOC2
(miRNA target sites are highlighted)
>SHOC2|NM_007373|3'UTR
   1 TATAAATCTGCTGGTCCCACACACTGTTCAAAAATAGACTGCCATTAATGTTTCTTATCTATATCTGTATCTATTTATGT
  81 AGATATTGGTATATGGCAGATTTATAAAAATTGCATTATGTGTTTCTGCTAATAGAGGAATCATAGCCATTTAGAATTTT
 161 TTTTAAATTCTGTACAAAAGGCTTATATAAGTTTTCTTTGCTGAATTTGATGGATGTTTTTCTGTTGTGTAATCTGATAT
 241 GCCAGTTTGCTTAAAACATTTGCCAACACATTATGAAGTTATTAAATTTAAGGGACAGAGGTAGTATAGTTAGATATACT
 321 TTCTCTTAGGAAAAATAATGGGCAAAAATTTTTGTTGCAACTTTTCATATATATTTTCCCCTTACCAATTGTTTTATCCT
 401 TATAGTATTGTAGGCCCTGAAAGTAGAATTTTTCTTTAACTTATTTTGAGATTTGAGATTTAAATTTTATGTATTGTTTA
 481 CAGTCAGAGTAAATCACTGGATTTCTTTTGTTTGTTTTGATTTGCTCTGTTTTATTCAGTCAAATCTAGAGTTTGAATCC
 561 TCTGCTAAAGAATTTGCATCCACTGGTGTAAACAGTGAAAGGTATTTGCTTGTTGAAAAAAAAAACTGGCAAAGTGAAAA
 641 GATACAGTCAAAAATCTAGAATTTCTTTAATTTTGCTTCTCTGACGAGTTGTGAAGCAAAATACCTGAAGTGAGTCTTTG
 721 GGTAGGGGAAGGGTATTGAGACCTTTTCTAGTATGAATATTTTTTAAGTTTGGGGGAAGAGAAACTTGCAGTGAAAAGGA
 801 GTTTTTTCATTCCTGAAAGTTGCAGATCCACAAAACTAACAGGATAATTGGGCAAATAAATTACATATAAACACACACAA
 881 TCTATATATGTATATACAATGCTATATAGATATGTATTTATTATATCATAAACTACAGTAGGTAACTTTAAGGATTTCTT
 961 CCTATCCTTGTACAATGACATGAATGTCTTTCTTTGAAAACTGCAATGTATGTATGTTTCAAGGTTATTTAACAGTGTAC
1041 TATGGTTTTATATCTTGACTTGCCTTGTACATCTTTCAATTCTGGAATATCTGTGTCTAAGCACAATATCTTCACACTGT
1121 GCTGTATTGCTGCTGAACTAAATGCACTTTTCCCCACATATGGGGCACTGGCTTCAAACAATTCAGTTCAGTATCATTAC
1201 TTTTAATCTCATCTTTCCTTTCTTGGTAGTTGTTAATACAGTTATGGAAAAGAGGCACATTGCATAGAAGCCATTGGGGA
1281 GTTCAGTGGAAGTTCTGTAAGATGTGCATGTACTATTTGATGCGTTTTCTTTGCTTCACTGCTTTTAATACTTAGCAGTA
1361 TTGTTGGTCTAAGTCAATTTGATTATTGAGGAGTCTCAGAGCAAGGTGCGTTCTAGATGTCATCCTAAAAAACACTTCAT
1441 ATATAATTAATCACTATTTTGTATAATTACATATTGCTGCTTGTGTGTTTTTTTTTTTTTCCATTTAGTTGGGCGTTGTG
1521 TTTTACACAAAACCATTTTTGAATTAAGGCTATGATATTAAGATAGAAATTTGGACTGTTGTTCTGCTTTTCCTGGCACT
1601 CAAATTCATGACTAGTTTTGAGGTCAAACCTATGTTCGTAATGAGAGATTTTATAAGGATCAACTAAGAAATGGAAGGCA
1681 GGTGAAGATATAAAACCCTAGAATGCTTAAATGTGCTGTAAAACTATTGTAGATGTCACTGGATTTTACCAAGTAATATC
1761 CTTTCTTTTTTTTTTCCCCCCATCTGCTGTGGCTTTTCAGTTAAAATTTTGTTTATAAAAGGAATTTGTTTATTACAGCT
1841 CTACCTAGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gguaGAAGGAAGUCGGag 5'
              :||: |||||:|  
Target 5' tctgTTTTATTCAGTCaa 3'
526 - 543 118.00 -9.90
2
miRNA  3' ggUAGAAGGAAGUCGGAg 5'
            ||:||:|||:| |:| 
Target 5' gaATTTTTCTTTAACTTa 3'
426 - 443 108.00 -9.00
3
miRNA  3' gguAGAAG-GAAGU--CGGAg 5'
             ||||: |||||  ||:| 
Target 5' tttTCTTTGCTTCACTGCTTt 3'
1325 - 1345 107.00 -10.06
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
181525 4 ClinVar
378581 17 ClinVar
984487 17 ClinVar
879344 21 ClinVar
298865 165 ClinVar
298866 405 ClinVar
298867 506 ClinVar
298868 519 ClinVar
298869 615 ClinVar
298870 616 ClinVar
298871 657 ClinVar
879705 686 ClinVar
298872 698 ClinVar
298873 774 ClinVar
879706 826 ClinVar
298874 915 ClinVar
298875 959 ClinVar
877760 980 ClinVar
877761 991 ClinVar
298876 1062 ClinVar
298877 1107 ClinVar
298878 1219 ClinVar
298879 1246 ClinVar
877762 1270 ClinVar
298880 1324 ClinVar
298881 1325 ClinVar
878792 1382 ClinVar
298882 1484 ClinVar
298883 1486 ClinVar
298884 1487 ClinVar
298885 1488 ClinVar
298886 1504 ClinVar
878793 1509 ClinVar
298887 1576 ClinVar
298888 1766 ClinVar
298889 1776 ClinVar
COSN30518494 17 COSMIC
COSN30453026 23 COSMIC
COSN30599808 47 COSMIC
COSN31554104 147 COSMIC
COSN8529214 147 COSMIC
COSN28840592 165 COSMIC
COSN26056258 210 COSMIC
COSN6056671 264 COSMIC
COSN6056672 419 COSMIC
COSN16529725 726 COSMIC
COSN17540041 967 COSMIC
COSN16698609 1010 COSMIC
COSN23635756 1094 COSMIC
COSN26551615 1125 COSMIC
COSN26556972 1136 COSMIC
COSN15325663 1161 COSMIC
COSN28797786 1293 COSMIC
COSN28939734 1488 COSMIC
COSN20107548 1501 COSMIC
COSN14463567 1603 COSMIC
COSN23108089 1776 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs767523465 3 dbSNP
rs143187497 4 dbSNP
rs760047969 11 dbSNP
rs377043455 12 dbSNP
rs938277839 14 dbSNP
rs574959049 16 dbSNP
rs753327392 17 dbSNP
rs371005619 21 dbSNP
rs753016007 22 dbSNP
rs1355437825 24 dbSNP
rs1455226481 27 dbSNP
rs944382341 36 dbSNP
rs1301838443 38 dbSNP
rs1353178224 39 dbSNP
rs758762850 45 dbSNP
rs1293346959 47 dbSNP
rs1317261860 51 dbSNP
rs1222504732 62 dbSNP
rs775803610 62 dbSNP
rs1169548041 66 dbSNP
rs1040144710 68 dbSNP
rs575011429 70 dbSNP
rs1421610660 72 dbSNP
rs542333379 74 dbSNP
rs1196568516 84 dbSNP
rs866531238 87 dbSNP
rs1248746001 91 dbSNP
rs1479832656 96 dbSNP
rs1482109220 98 dbSNP
rs1224246962 100 dbSNP
rs377205004 101 dbSNP
rs1181615270 102 dbSNP
rs1042167767 105 dbSNP
rs1204306036 108 dbSNP
rs1252410751 111 dbSNP
rs900213298 114 dbSNP
rs931728986 115 dbSNP
rs902242330 116 dbSNP
rs761226703 119 dbSNP
rs1412730473 123 dbSNP
rs1284044651 141 dbSNP
rs936410980 145 dbSNP
rs772535731 150 dbSNP
rs1297359330 157 dbSNP
rs896472847 157 dbSNP
rs191293913 165 dbSNP
rs1402299398 166 dbSNP
rs201494424 175 dbSNP
rs1166465738 184 dbSNP
rs1174166137 184 dbSNP
rs900133151 188 dbSNP
rs969409307 192 dbSNP
rs1200399961 209 dbSNP
rs1368377995 213 dbSNP
rs576218739 217 dbSNP
rs996096984 230 dbSNP
rs1030249563 233 dbSNP
rs890328883 241 dbSNP
rs1481154857 243 dbSNP
rs1308151104 250 dbSNP
rs1260463910 252 dbSNP
rs1005107793 259 dbSNP
rs1323504842 271 dbSNP
rs1351827066 280 dbSNP
rs1444927340 281 dbSNP
rs1334140796 283 dbSNP
rs1015699953 290 dbSNP
rs542446944 293 dbSNP
rs543400072 294 dbSNP
rs1378832463 302 dbSNP
rs1334494312 307 dbSNP
rs1469210520 308 dbSNP
rs764385450 310 dbSNP
rs1406772865 315 dbSNP
rs1173750036 324 dbSNP
rs957249586 331 dbSNP
rs1362769468 332 dbSNP
rs989120443 349 dbSNP
rs1441202810 352 dbSNP
rs1378901885 353 dbSNP
rs182433736 354 dbSNP
rs1229311118 359 dbSNP
rs1461231568 362 dbSNP
rs1026947396 368 dbSNP
rs944608848 372 dbSNP
rs959364848 380 dbSNP
rs975712602 381 dbSNP
rs1260287622 386 dbSNP
rs539394184 405 dbSNP
rs918158727 406 dbSNP
rs1204745760 408 dbSNP
rs970944296 414 dbSNP
rs1312594067 415 dbSNP
rs1451650872 416 dbSNP
rs978684067 429 dbSNP
rs532446734 431 dbSNP
rs1383364226 434 dbSNP
rs1336075730 437 dbSNP
rs1275382202 454 dbSNP
rs931697816 459 dbSNP
rs1288991319 486 dbSNP
rs1048829012 488 dbSNP
rs1439647217 494 dbSNP
rs1421085522 495 dbSNP
rs1383039352 496 dbSNP
rs887931765 501 dbSNP
rs541359882 502 dbSNP
rs1161987839 503 dbSNP
rs371679867 506 dbSNP
rs1236900795 507 dbSNP
rs1190217442 508 dbSNP
rs1472995511 511 dbSNP
rs924105012 511 dbSNP
rs936426575 516 dbSNP
rs886046731 519 dbSNP
rs559270881 524 dbSNP
rs896700397 528 dbSNP
rs1053493127 532 dbSNP
rs921636466 541 dbSNP
rs1245593167 542 dbSNP
rs931627740 557 dbSNP
rs573586846 560 dbSNP
rs1051710493 570 dbSNP
rs1448456922 571 dbSNP
rs905219486 579 dbSNP
rs1325805726 584 dbSNP
rs1168857275 589 dbSNP
rs1401314899 591 dbSNP
rs890349094 593 dbSNP
rs1004777626 596 dbSNP
rs1302137196 602 dbSNP
rs1424979589 606 dbSNP
rs1391868200 613 dbSNP
rs886046732 615 dbSNP
rs1032456352 616 dbSNP
rs886046733 616 dbSNP
rs957423845 616 dbSNP
rs1194401816 617 dbSNP
rs1010032840 624 dbSNP
rs1036617326 627 dbSNP
rs1020545643 634 dbSNP
rs1452454829 635 dbSNP
rs1359147806 636 dbSNP
rs1291695937 640 dbSNP
rs965923949 643 dbSNP
rs560726584 646 dbSNP
rs898963211 650 dbSNP
rs1363493914 651 dbSNP
rs557334390 657 dbSNP
rs1220462515 660 dbSNP
rs1343095268 678 dbSNP
rs749942762 686 dbSNP
rs984941982 687 dbSNP
rs1198858390 689 dbSNP
rs1332486270 692 dbSNP
rs1325898196 694 dbSNP
rs189140753 698 dbSNP
rs1396298913 708 dbSNP
rs148246156 713 dbSNP
rs1427259549 720 dbSNP
rs1036496682 725 dbSNP
rs1024952105 745 dbSNP
rs1478454262 761 dbSNP
rs114628508 774 dbSNP
rs1179330179 776 dbSNP
rs978335298 785 dbSNP
rs1258551680 789 dbSNP
rs1464279974 790 dbSNP
rs924106725 793 dbSNP
rs193126887 799 dbSNP
rs989262645 810 dbSNP
rs905188414 817 dbSNP
rs1219340794 821 dbSNP
rs921664394 826 dbSNP
rs1277394430 834 dbSNP
rs1441111625 837 dbSNP
rs1335514894 841 dbSNP
rs1332517146 843 dbSNP
rs1449588119 848 dbSNP
rs185620695 852 dbSNP
rs1476745147 866 dbSNP
rs1404572126 867 dbSNP
rs1175712976 868 dbSNP
rs1415124112 871 dbSNP
rs1427429588 873 dbSNP
rs1157045067 875 dbSNP
rs540708199 880 dbSNP
rs1469857967 884 dbSNP
rs931658865 887 dbSNP
rs1180300814 892 dbSNP
rs1425301590 893 dbSNP
rs1459895177 893 dbSNP
rs1242463257 898 dbSNP
rs766192638 903 dbSNP
rs751455255 905 dbSNP
rs1051445922 908 dbSNP
rs1210798748 911 dbSNP
rs1415498566 914 dbSNP
rs1054277943 915 dbSNP
rs189223963 915 dbSNP
rs940610806 928 dbSNP
rs192135385 930 dbSNP
rs1242769222 935 dbSNP
rs1381147331 937 dbSNP
rs1302765704 940 dbSNP
rs1449495369 947 dbSNP
rs1434913555 950 dbSNP
rs1316376326 953 dbSNP
rs372493479 959 dbSNP
rs1160168322 974 dbSNP
rs1381187671 974 dbSNP
rs1442529300 978 dbSNP
rs994617323 980 dbSNP
rs1231118801 985 dbSNP
rs1048485840 986 dbSNP
rs1274288913 991 dbSNP
rs1484222860 994 dbSNP
rs895255595 1006 dbSNP
rs1345831053 1007 dbSNP
rs568680803 1025 dbSNP
rs1266166977 1028 dbSNP
rs1464266150 1039 dbSNP
rs536012063 1041 dbSNP
rs1209180040 1043 dbSNP
rs1488373301 1052 dbSNP
rs1287730466 1058 dbSNP
rs1263374537 1059 dbSNP
rs1449477956 1061 dbSNP
rs530047047 1062 dbSNP
rs886046734 1062 dbSNP
rs1312516949 1064 dbSNP
rs1025405291 1065 dbSNP
rs557280270 1079 dbSNP
rs906496375 1080 dbSNP
rs1229376057 1090 dbSNP
rs751517745 1092 dbSNP
rs1268453719 1094 dbSNP
rs1399485023 1101 dbSNP
rs1361349390 1105 dbSNP
rs118172559 1107 dbSNP
rs997422272 1108 dbSNP
rs1031242870 1109 dbSNP
rs1165245122 1117 dbSNP
rs1481134517 1133 dbSNP
rs1417298918 1134 dbSNP
rs184177524 1140 dbSNP
rs1179205114 1155 dbSNP
rs1477853004 1156 dbSNP
rs958219170 1158 dbSNP
rs1410473061 1162 dbSNP
rs1457023571 1166 dbSNP
rs1160421289 1171 dbSNP
rs1490099635 1173 dbSNP
rs1387633035 1174 dbSNP
rs1222813984 1181 dbSNP
rs1323961016 1185 dbSNP
rs1028950726 1188 dbSNP
rs953024686 1194 dbSNP
rs984436423 1209 dbSNP
rs1280230768 1210 dbSNP
rs1403283625 1212 dbSNP
rs1367202930 1218 dbSNP
rs886046735 1219 dbSNP
rs908876475 1223 dbSNP
rs961790746 1229 dbSNP
rs972240205 1232 dbSNP
rs1169871048 1236 dbSNP
rs1466115990 1240 dbSNP
rs1425127004 1241 dbSNP
rs754913685 1246 dbSNP
rs1479883283 1248 dbSNP
rs1029142477 1259 dbSNP
rs953120890 1260 dbSNP
rs1315571572 1265 dbSNP
rs772654155 1270 dbSNP
rs1231566697 1278 dbSNP
rs911549613 1282 dbSNP
rs141791891 1298 dbSNP
rs972421078 1305 dbSNP
rs576948558 1306 dbSNP
rs1286362382 1309 dbSNP
rs936926753 1314 dbSNP
rs1053763780 1317 dbSNP
rs1330487326 1320 dbSNP
rs371721188 1324 dbSNP
rs559572636 1325 dbSNP
rs1173551406 1332 dbSNP
rs894280946 1339 dbSNP
rs1041181045 1340 dbSNP
rs1177747592 1353 dbSNP
rs1416986919 1355 dbSNP
rs1236675268 1356 dbSNP
rs948143573 1365 dbSNP
rs188505184 1378 dbSNP
rs1240587158 1379 dbSNP
rs747905159 1381 dbSNP
rs997392575 1382 dbSNP
rs1482963417 1387 dbSNP
rs1256707298 1388 dbSNP
rs1235668007 1393 dbSNP
rs757582531 1395 dbSNP
rs1046472169 1410 dbSNP
rs779208280 1411 dbSNP
rs541969990 1418 dbSNP
rs1378950926 1420 dbSNP
rs1290232538 1421 dbSNP
rs1334595294 1428 dbSNP
rs1490693236 1432 dbSNP
rs780618180 1442 dbSNP
rs745972322 1443 dbSNP
rs796796451 1446 dbSNP
rs1304098805 1457 dbSNP
rs1451120924 1462 dbSNP
rs563188768 1464 dbSNP
rs1379303470 1472 dbSNP
rs199880082 1482 dbSNP
rs180979375 1484 dbSNP
rs1456714361 1485 dbSNP
rs1382621262 1486 dbSNP
rs549502834 1486 dbSNP
rs753811687 1486 dbSNP
rs776585204 1486 dbSNP
rs143768227 1487 dbSNP
rs759715534 1487 dbSNP
rs7074770 1488 dbSNP
rs769907720 1488 dbSNP
rs771402535 1488 dbSNP
rs1355581834 1489 dbSNP
rs971773144 1489 dbSNP
rs1312708932 1490 dbSNP
rs552284342 1491 dbSNP
rs1341022670 1493 dbSNP
rs1306221023 1501 dbSNP
rs1314154214 1501 dbSNP
rs1349977761 1502 dbSNP
rs1410300255 1503 dbSNP
rs1327552 1504 dbSNP
rs1309063358 1507 dbSNP
rs1338482281 1508 dbSNP
rs202206864 1509 dbSNP
rs1362824766 1510 dbSNP
rs1265641641 1512 dbSNP
rs1161852458 1513 dbSNP
rs528458429 1515 dbSNP
rs1369554224 1516 dbSNP
rs1189645426 1524 dbSNP
rs771841691 1524 dbSNP
rs1273217366 1529 dbSNP
rs1483103637 1537 dbSNP
rs980866319 1553 dbSNP
rs1031691813 1560 dbSNP
rs1194621920 1572 dbSNP
rs886046736 1576 dbSNP
rs1489405248 1580 dbSNP
rs1287419229 1585 dbSNP
rs1209023344 1588 dbSNP
rs1196815863 1600 dbSNP
rs1356886424 1605 dbSNP
rs926807353 1605 dbSNP
rs747506750 1609 dbSNP
rs936915996 1611 dbSNP
rs990164034 1616 dbSNP
rs865926990 1621 dbSNP
rs913891085 1626 dbSNP
rs1801901 1630 dbSNP
rs945404848 1633 dbSNP
rs1446622504 1634 dbSNP
rs546692011 1638 dbSNP
rs1166964077 1639 dbSNP
rs1041149992 1642 dbSNP
rs568695891 1683 dbSNP
rs953485111 1692 dbSNP
rs901220679 1707 dbSNP
rs1464559931 1716 dbSNP
rs1801900 1719 dbSNP
rs1422945226 1726 dbSNP
rs932733512 1731 dbSNP
rs373459532 1753 dbSNP
rs1462620843 1756 dbSNP
rs1299800886 1760 dbSNP
rs1245211042 1766 dbSNP
rs527775221 1766 dbSNP
rs886046737 1766 dbSNP
rs888963635 1767 dbSNP
rs1269247858 1772 dbSNP
rs1247310563 1776 dbSNP
rs535776105 1776 dbSNP
rs1219941211 1782 dbSNP
rs1313108211 1793 dbSNP
rs777538590 1803 dbSNP
rs1018684517 1804 dbSNP
rs551193817 1815 dbSNP
rs971775017 1824 dbSNP
rs746829098 1825 dbSNP
rs1296419884 1835 dbSNP
rs1326008783 1837 dbSNP
rs993162076 1839 dbSNP
rs1342244561 1842 dbSNP
rs920235268 1844 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ggUAGAAGGA---AGUCGGAg 5'
            ||: ||||   ||||||| 
Target 5' auAUUCUCCUGCCUCAGCCUc 3'
3 - 23
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000369452.4 | 3UTR | UUAUAUUCUCCUGCCUCAGCCUCCUGAGUAGCUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000369452.4 | 3UTR | CUCUGAAAGUGCUGGGAUUACAGGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
390 hsa-miR-4419b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061343 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT072743 GLCE glucuronic acid epimerase 2 2
MIRT180549 TXNIP thioredoxin interacting protein 2 2
MIRT186147 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT271044 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 4
MIRT334761 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 6
MIRT443279 TSPAN15 tetraspanin 15 2 2
MIRT447047 ZNF439 zinc finger protein 439 2 2
MIRT447351 KIF6 kinesin family member 6 2 2
MIRT448925 CKS1B CDC28 protein kinase regulatory subunit 1B 2 2
MIRT452899 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT453087 SUMF2 sulfatase modifying factor 2 2 2
MIRT454071 SLC35E3 solute carrier family 35 member E3 2 2
MIRT456216 LIX1L limb and CNS expressed 1 like 2 6
MIRT456951 LRP10 LDL receptor related protein 10 2 2
MIRT458025 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT459999 RFT1 RFT1 homolog 2 2
MIRT460046 CDCP1 CUB domain containing protein 1 2 2
MIRT460982 STK17B serine/threonine kinase 17b 2 2
MIRT464405 URM1 ubiquitin related modifier 1 2 2
MIRT466256 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT466536 TBXA2R thromboxane A2 receptor 2 2
MIRT470922 PLD5 phospholipase D family member 5 2 8
MIRT472835 MTMR10 myotubularin related protein 10 2 6
MIRT473352 MEMO1 mediator of cell motility 1 2 2
MIRT475504 HSP90B1 heat shock protein 90 beta family member 1 2 2
MIRT478862 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT480898 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT482686 NXN nucleoredoxin 2 4
MIRT484128 C14orf142 GON7, KEOPS complex subunit homolog 2 2
MIRT486172 TLE3 transducin like enhancer of split 3 2 4
MIRT486539 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486588 ZNF619 zinc finger protein 619 2 2
MIRT495475 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT495536 TXNRD2 thioredoxin reductase 2 2 2
MIRT495566 UNC5C unc-5 netrin receptor C 2 2
MIRT495719 PADI1 peptidyl arginine deiminase 1 2 2
MIRT495890 CLOCK clock circadian regulator 2 2
MIRT495932 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT496026 ZBED3 zinc finger BED-type containing 3 2 2
MIRT496216 PAX6 paired box 6 2 2
MIRT496349 VAMP1 vesicle associated membrane protein 1 2 2
MIRT496354 PPY pancreatic polypeptide 2 2
MIRT496400 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT496416 PARVB parvin beta 2 2
MIRT496458 N6AMT1 N-6 adenine-specific DNA methyltransferase 1 2 2
MIRT496519 GINS2 GINS complex subunit 2 2 2
MIRT496562 SLC39A9 solute carrier family 39 member 9 2 2
MIRT498605 KRT8 keratin 8 2 2
MIRT503434 SLC25A45 solute carrier family 25 member 45 2 6
MIRT503573 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT503847 ATP13A4 ATPase 13A4 2 4
MIRT504247 LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2 4
MIRT505606 SLC35F1 solute carrier family 35 member F1 2 2
MIRT507749 CERS2 ceramide synthase 2 2 4
MIRT508411 C1orf210 chromosome 1 open reading frame 210 2 6
MIRT508508 RSRC1 arginine and serine rich coiled-coil 1 2 6
MIRT508944 AK4 adenylate kinase 4 2 4
MIRT509460 ZNF587 zinc finger protein 587 2 6
MIRT509862 ZNF641 zinc finger protein 641 2 4
MIRT511397 IKZF3 IKAROS family zinc finger 3 2 6
MIRT512517 BTBD19 BTB domain containing 19 2 2
MIRT513507 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 6
MIRT514155 TMEM145 transmembrane protein 145 2 4
MIRT514486 SLPI secretory leukocyte peptidase inhibitor 2 4
MIRT514521 SHISA9 shisa family member 9 2 2
MIRT514970 KLLN killin, p53-regulated DNA replication inhibitor 2 4
MIRT515030 IRAK4 interleukin 1 receptor associated kinase 4 2 6
MIRT515963 C9orf156 tRNA methyltransferase O 2 2
MIRT516092 ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 2 4
MIRT517223 PRIM1 DNA primase subunit 1 2 4
MIRT517459 PEX26 peroxisomal biogenesis factor 26 2 4
MIRT517790 EFCAB11 EF-hand calcium binding domain 11 2 2
MIRT517979 DSCR3 DSCR3 arrestin fold containing 2 2
MIRT519458 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT519599 ZNF805 zinc finger protein 805 2 2
MIRT520339 UBXN2A UBX domain protein 2A 2 2
MIRT521345 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT521571 PTPLB 3-hydroxyacyl-CoA dehydratase 2 1 1
MIRT523382 GSG2 histone H3 associated protein kinase 2 8
MIRT524106 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT524886 ARHGAP11A Rho GTPase activating protein 11A 2 4
MIRT528772 CD1D CD1d molecule 2 2
MIRT530665 TRIM56 tripartite motif containing 56 2 2
MIRT531107 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT531575 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT535173 PLEKHB2 pleckstrin homology domain containing B2 2 4
MIRT544168 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT550582 SLC2A5 solute carrier family 2 member 5 2 2
MIRT551039 GDE1 glycerophosphodiester phosphodiesterase 1 2 4
MIRT551295 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT551339 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT552092 SLFN12L schlafen family member 12 like 2 6
MIRT555403 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT557087 HOXB3 homeobox B3 2 2
MIRT559388 ATP11C ATPase phospholipid transporting 11C 2 2
MIRT560305 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT561028 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT562460 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT562982 PARK7 Parkinsonism associated deglycase 2 2
MIRT563548 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT564412 EMILIN2 elastin microfibril interfacer 2 2 4
MIRT569437 PCGF3 polycomb group ring finger 3 2 2
MIRT572097 EXOC8 exocyst complex component 8 2 2
MIRT575571 Cd99 CD99 antigen 2 2
MIRT575789 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT576975 Lmtk2 lemur tyrosine kinase 2 2 2
MIRT610864 ARSA arylsulfatase A 2 2
MIRT614061 NTPCR nucleoside-triphosphatase, cancer-related 2 2
MIRT614141 THAP1 THAP domain containing 1 2 6
MIRT615235 BROX BRO1 domain and CAAX motif containing 2 2
MIRT617429 ANP32E acidic nuclear phosphoprotein 32 family member E 2 4
MIRT618882 MBL2 mannose binding lectin 2 2 2
MIRT618984 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT619196 SLC16A4 solute carrier family 16 member 4 2 2
MIRT620323 AQP6 aquaporin 6 2 2
MIRT621960 STX7 syntaxin 7 2 2
MIRT622057 SSBP2 single stranded DNA binding protein 2 2 2
MIRT624930 FBXW2 F-box and WD repeat domain containing 2 2 2
MIRT624986 ZNF665 zinc finger protein 665 2 4
MIRT625463 ZNF681 zinc finger protein 681 2 4
MIRT625497 SMAD9 SMAD family member 9 2 2
MIRT625599 KLHL23 kelch like family member 23 2 2
MIRT625668 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT625888 INADL PATJ, crumbs cell polarity complex component 2 2
MIRT626161 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626238 ZNF749 zinc finger protein 749 2 2
MIRT626631 SLC30A6 solute carrier family 30 member 6 2 2
MIRT626994 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT627898 OLFML2A olfactomedin like 2A 2 2
MIRT627988 NDRG3 NDRG family member 3 2 2
MIRT628324 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT628549 ZNF701 zinc finger protein 701 2 2
MIRT629464 WIZ widely interspaced zinc finger motifs 2 2
MIRT630527 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT631487 KLHL21 kelch like family member 21 2 2
MIRT631957 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 4
MIRT632178 CCL22 C-C motif chemokine ligand 22 2 2
MIRT632282 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT632321 TMEM185B transmembrane protein 185B 2 2
MIRT632853 IGF1 insulin like growth factor 1 2 2
MIRT632862 HSPA2 heat shock protein family A (Hsp70) member 2 2 2
MIRT633322 LINC00346 long intergenic non-protein coding RNA 346 2 2
MIRT633398 FBXW8 F-box and WD repeat domain containing 8 2 2
MIRT633930 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT634785 CBFA2T2 CBFA2/RUNX1 translocation partner 2 2 2
MIRT634851 ABCF1 ATP binding cassette subfamily F member 1 2 2
MIRT636370 OGFRL1 opioid growth factor receptor like 1 2 2
MIRT637219 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT637690 PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D 2 2
MIRT639196 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT639599 CD3EAP CD3e molecule associated protein 2 2
MIRT639681 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT640669 ARSK arylsulfatase family member K 2 2
MIRT642377 ZNF581 zinc finger protein 581 2 2
MIRT642403 ZNF556 zinc finger protein 556 2 2
MIRT645079 UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII 2 2
MIRT646475 ZNF669 zinc finger protein 669 2 2
MIRT647325 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT647490 ZNF639 zinc finger protein 639 2 2
MIRT647989 PDE12 phosphodiesterase 12 2 2
MIRT648196 CENPN centromere protein N 2 2
MIRT649006 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT650457 ZNF141 zinc finger protein 141 2 2
MIRT650533 CCDC77 coiled-coil domain containing 77 2 2
MIRT650999 ZNF770 zinc finger protein 770 2 2
MIRT653832 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 4
MIRT655734 NRXN3 neurexin 3 2 2
MIRT657577 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT658610 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 2
MIRT658633 ENAH ENAH, actin regulator 2 2
MIRT659820 CASP16 caspase 16, pseudogene 2 2
MIRT661142 ZNF43 zinc finger protein 43 2 2
MIRT661201 MPPE1 metallophosphoesterase 1 2 2
MIRT661436 MANSC1 MANSC domain containing 1 2 2
MIRT661498 CHMP1B charged multivesicular body protein 1B 2 2
MIRT661682 ZNF623 zinc finger protein 623 2 2
MIRT661796 NLRC3 NLR family CARD domain containing 3 2 2
MIRT661808 NUP85 nucleoporin 85 2 2
MIRT661861 ZNF766 zinc finger protein 766 2 2
MIRT661889 EXOSC6 exosome component 6 2 2
MIRT662291 SLC29A4 solute carrier family 29 member 4 2 2
MIRT662515 ANGPT4 angiopoietin 4 2 2
MIRT662682 LRRC47 leucine rich repeat containing 47 2 2
MIRT662716 C10orf111 chromosome 10 open reading frame 111 2 4
MIRT662834 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT662890 PCDHA6 protocadherin alpha 6 2 2
MIRT663134 ULBP3 UL16 binding protein 3 2 2
MIRT663710 ABHD17B abhydrolase domain containing 17B 2 2
MIRT663869 MUC20 mucin 20, cell surface associated 2 2
MIRT664267 NMUR1 neuromedin U receptor 1 2 2
MIRT664510 POLR3K RNA polymerase III subunit K 2 2
MIRT664659 TRIM65 tripartite motif containing 65 2 2
MIRT664849 HUS1 HUS1 checkpoint clamp component 2 2
MIRT664944 CARD6 caspase recruitment domain family member 6 2 4
MIRT665348 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT665514 UTP15 UTP15, small subunit processome component 2 2
MIRT665648 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT665668 TRAF1 TNF receptor associated factor 1 2 2
MIRT665692 TNPO3 transportin 3 2 2
MIRT665741 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT665850 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT665940 TBC1D19 TBC1 domain family member 19 2 4
MIRT666005 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT666172 SNX27 sorting nexin family member 27 2 4
MIRT666373 SHOX short stature homeobox 2 2
MIRT667004 PDPN podoplanin 2 4
MIRT667185 NR2F6 nuclear receptor subfamily 2 group F member 6 2 4
MIRT667603 LIPC lipase C, hepatic type 2 2
MIRT667828 IRGQ immunity related GTPase Q 2 2
MIRT667862 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT668296 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 4
MIRT668463 FAM208A family with sequence similarity 208 member A 2 2
MIRT668580 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 4
MIRT669012 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT669103 CDK19 cyclin dependent kinase 19 2 2
MIRT670073 ZNF783 zinc finger family member 783 2 2
MIRT670326 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670756 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670964 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT670985 MED17 mediator complex subunit 17 2 2
MIRT671195 ZNF891 zinc finger protein 891 2 2
MIRT672423 SLC10A6 solute carrier family 10 member 6 2 2
MIRT672495 YIPF4 Yip1 domain family member 4 2 2
MIRT672537 MGAM maltase-glucoamylase 2 2
MIRT672749 ZNF585B zinc finger protein 585B 2 4
MIRT673390 ZNF124 zinc finger protein 124 2 2
MIRT673452 ZNF583 zinc finger protein 583 2 2
MIRT673917 DCTN6 dynactin subunit 6 2 2
MIRT673952 ZNF500 zinc finger protein 500 2 2
MIRT674102 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674167 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674206 FUT2 fucosyltransferase 2 2 2
MIRT674452 PURB purine rich element binding protein B 2 4
MIRT674687 PLCE1 phospholipase C epsilon 1 2 2
MIRT674701 TMEM59 transmembrane protein 59 2 2
MIRT674800 NPR1 natriuretic peptide receptor 1 2 4
MIRT675247 MAK male germ cell associated kinase 2 2
MIRT676012 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676374 APTX aprataxin 2 2
MIRT676834 TNFSF15 TNF superfamily member 15 2 2
MIRT678193 CRCP CGRP receptor component 2 2
MIRT678293 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT679532 RAB36 RAB36, member RAS oncogene family 2 2
MIRT679669 RABAC1 Rab acceptor 1 2 2
MIRT679850 GPR75 G protein-coupled receptor 75 2 2
MIRT680533 PRIM2 DNA primase subunit 2 2 2
MIRT680563 ZNF584 zinc finger protein 584 2 2
MIRT680577 PGPEP1 pyroglutamyl-peptidase I 2 2
MIRT680849 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT680888 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like 2 2
MIRT680940 EVC EvC ciliary complex subunit 1 2 2
MIRT680964 SLC15A1 solute carrier family 15 member 1 2 4
MIRT681017 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT681065 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT681209 ZNF638 zinc finger protein 638 2 2
MIRT681291 RFC2 replication factor C subunit 2 2 2
MIRT681366 BRI3BP BRI3 binding protein 2 2
MIRT681517 STAT2 signal transducer and activator of transcription 2 2 2
MIRT681549 ZNF738 zinc finger protein 738 2 2
MIRT681574 ABHD15 abhydrolase domain containing 15 2 2
MIRT681597 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT681806 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681912 SLC11A2 solute carrier family 11 member 2 2 2
MIRT681953 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682037 AGXT2 alanine--glyoxylate aminotransferase 2 2 4
MIRT682111 ITGA3 integrin subunit alpha 3 2 4
MIRT682190 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682247 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682394 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682554 EXOSC2 exosome component 2 2 2
MIRT682665 CASP8 caspase 8 2 2
MIRT683283 ZNF99 zinc finger protein 99 2 2
MIRT683359 SCARF1 scavenger receptor class F member 1 2 2
MIRT683453 ACOT2 acyl-CoA thioesterase 2 2 2
MIRT683596 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT683661 ZNF695 zinc finger protein 695 2 2
MIRT683770 CPE carboxypeptidase E 2 2
MIRT683807 NOTO notochord homeobox 2 2
MIRT684462 MFSD4 major facilitator superfamily domain containing 4A 2 2
MIRT684525 C1orf174 chromosome 1 open reading frame 174 2 2
MIRT684985 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT685012 CXorf56 chromosome X open reading frame 56 2 2
MIRT685072 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685115 DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 2 2
MIRT685477 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT685831 SLC27A1 solute carrier family 27 member 1 2 2
MIRT686032 UMPS uridine monophosphate synthetase 2 2
MIRT686559 TPM3 tropomyosin 3 2 2
MIRT687287 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT687309 OTUD7B OTU deubiquitinase 7B 2 2
MIRT688085 GLUL glutamate-ammonia ligase 2 2
MIRT688168 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT688584 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT688601 CYCS cytochrome c, somatic 2 2
MIRT688921 C11orf84 chromosome 11 open reading frame 84 2 2
MIRT689285 C5AR2 complement component 5a receptor 2 2 2
MIRT689622 AKAP6 A-kinase anchoring protein 6 2 2
MIRT690051 C6orf141 chromosome 6 open reading frame 141 2 2
MIRT690224 C5orf45 MRN complex interacting protein 2 2
MIRT690272 CAMLG calcium modulating ligand 2 2
MIRT690331 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT690480 ZNF33A zinc finger protein 33A 2 2
MIRT690526 ZNF566 zinc finger protein 566 2 2
MIRT690581 MICA MHC class I polypeptide-related sequence A 2 2
MIRT690675 RPF2 ribosome production factor 2 homolog 2 2
MIRT690790 ZNF589 zinc finger protein 589 2 2
MIRT690873 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT691142 HJURP Holliday junction recognition protein 2 2
MIRT691158 APOL6 apolipoprotein L6 2 2
MIRT691288 CENPM centromere protein M 2 2
MIRT691435 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT691749 IKBKG inhibitor of nuclear factor kappa B kinase subunit gamma 2 2
MIRT691833 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT691885 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT691947 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT692047 PAK1IP1 PAK1 interacting protein 1 2 2
MIRT692668 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT692767 NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 2 2
MIRT692859 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT693122 SCNM1 sodium channel modifier 1 2 2
MIRT693514 MOB3A MOB kinase activator 3A 2 2
MIRT693648 ACBD7 acyl-CoA binding domain containing 7 2 2
MIRT693688 MXRA7 matrix remodeling associated 7 2 2
MIRT694078 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT694163 SLC36A2 solute carrier family 36 member 2 2 2
MIRT694262 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT694506 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT694556 BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2 2
MIRT694639 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT694710 CD300LG CD300 molecule like family member g 2 2
MIRT694753 LLGL1 LLGL1, scribble cell polarity complex component 2 2
MIRT694896 ZNF417 zinc finger protein 417 2 2
MIRT695158 BTD biotinidase 2 2
MIRT695275 CD209 CD209 molecule 2 2
MIRT695434 TCF23 transcription factor 23 2 2
MIRT695817 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT696008 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT696345 SLC35D2 solute carrier family 35 member D2 2 2
MIRT696368 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT696533 C3 complement C3 2 2
MIRT696779 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT697075 PSMC4 proteasome 26S subunit, ATPase 4 2 2
MIRT697498 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT697630 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT697931 TXNDC16 thioredoxin domain containing 16 2 2
MIRT697966 TSPYL1 TSPY like 1 2 2
MIRT698237 TMEM216 transmembrane protein 216 2 2
MIRT698643 TES testin LIM domain protein 2 2
MIRT698661 TERF2 telomeric repeat binding factor 2 2 2
MIRT698974 SPAST spastin 2 2
MIRT699047 SOAT1 sterol O-acyltransferase 1 2 2
MIRT699193 SLX4IP SLX4 interacting protein 2 2
MIRT699586 SIKE1 suppressor of IKBKE 1 2 2
MIRT699759 SEPHS1 selenophosphate synthetase 1 2 2
MIRT700350 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT700402 RAB13 RAB13, member RAS oncogene family 2 2
MIRT700418 QDPR quinoid dihydropteridine reductase 2 2
MIRT700546 PTBP2 polypyrimidine tract binding protein 2 2 2
MIRT700774 PLA2G4A phospholipase A2 group IVA 2 2
MIRT700875 PER2 period circadian clock 2 2 2
MIRT700952 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT701077 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT701172 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT701479 NEK9 NIMA related kinase 9 2 2
MIRT701661 MYH9 myosin heavy chain 9 2 2
MIRT701779 MSL2 MSL complex subunit 2 2 2
MIRT702137 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT702494 KIAA1328 KIAA1328 2 2
MIRT703058 GTPBP10 GTP binding protein 10 2 2
MIRT703224 GOLGA3 golgin A3 2 2
MIRT703620 FBXO45 F-box protein 45 2 2
MIRT703657 FAM60A SIN3-HDAC complex associated factor 2 2
MIRT703765 FAM118A family with sequence similarity 118 member A 2 2
MIRT703832 EVI5 ecotropic viral integration site 5 2 2
MIRT703862 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT704664 CLCC1 chloride channel CLIC like 1 2 2
MIRT704812 CDC73 cell division cycle 73 2 2
MIRT705608 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT705625 AP1S3 adaptor related protein complex 1 sigma 3 subunit 2 2
MIRT705682 ANKRD40 ankyrin repeat domain 40 2 2
MIRT705813 AKNA AT-hook transcription factor 2 2
MIRT706238 SYT15 synaptotagmin 15 2 2
MIRT706567 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 2 2
MIRT709657 DFFB DNA fragmentation factor subunit beta 2 2
MIRT710609 ZNF555 zinc finger protein 555 2 2
MIRT711717 IREB2 iron responsive element binding protein 2 2 2
MIRT714122 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT715204 FKTN fukutin 2 2
MIRT718260 ZDHHC8 zinc finger DHHC-type containing 8 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4419b Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4419b Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4419b Cisplatin + Decitabine resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-mir-4419b Androstenedione+Anastrozole sensitive cell line (MCF-7)

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