miRTarBase - #MIRT653945


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pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol SEPSECS   
Synonyms LP, PCH2D, SLA, SLA/LP
Description Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Transcript NM_016955   
Expression
Putative miRNA Targets on SEPSECS
3'UTR of SEPSECS
(miRNA target sites are highlighted)		 
>SEPSECS|NM_016955|3'UTR
   1 CATGCGAAGGGTTTCTTCTTGATCATTTGAAAGAAATGATAAGGCTGTAGTACAAGCAAGCAGTTTAAAGATAAGACTTG
  81 AGATTTTTGAATTGAGAATTTCATGGGAATATTCAGTCAAGGAGCAGACTTTGGTCTGAACTAGCCATTGATGATTGTTA
 161 AGTTTCCCATTCTTAGACTGCATCAATCCTTGTGATCCTTAACAGGTTATAATATACAATTAGCATTTTTCTAATTGTTA
 241 GAATATCTGTCAATTAAGCATCATGACTCAGATAATTTTTACTAGTGTAATGACAGTAAAATTACTTCAATTCTCTTTGA
 321 AATGTAGAGTGCTTCCTCCTAACCATTCTTTACCGTTTCTGATCACACAGAATTGAGAAAGATCTCTTAGGCCACTAGTT
 401 ACTAGTTGTTTGTTGAGATGTGTAAGTCACAGTGTGCCTGTAAAATGGGCATTCCCCAAGGAAGCAGAGTCAAGGTATAA
 481 ACTTTCGTTTTGACTCAAAAGCAGTGGGTCTCAACTGGGGATGATTCGCTTATCTGAACAGCATCTGCAGACATTTTTGG
 561 TTGTCACAACTGGTGGGATGCTGTTAACATCTAGAGGATAGAGGCCAGGGTGCTACTCAACATCCTACAATGCATGGGAC
 641 AACTCCCACAACAAAGAATTATCCAGCCCAAAATGTCATTAGTGCTGAGGTTGAGAAATACTCCTCTAAAGTAGATAAAC
 721 TCCTTGAGTAAAGAGAAGTTTACCATAGCAACTTTCAGTAGTACTTCAAAGAAGATAGCTGTATAAATGTCATCAAACTA
 801 TACTATATAGAGAATCTTAAGTGATAACCAGGGTCACGGATTCCAAACATGTCATTATAAATTGTTTTATATGGTGCTCA
 881 CTGGTGCATTTTTCCTTTTGGATAAGGGAAAACATTATTCCACTTACTGTTTTTGCTTTAAGCAGCCTGCATATATTGGT
 961 TAGTTTGTTCAGATGTTGTGCACAGACATCATCAAAATTAGCTAACATGGGTATTTTTGAACATATTTTTGCCAGGAAGA
1041 TGAAAATCACATAGTATGATAAACAGGTGTATTCCCCTCTACTTGCCCATGTGCTCATTTTTCTGAGTCTGAAATTCCAG
1121 ACTTACTGGCTTTAACAATAATTTTTGTTGTTAATTTAAGAAATAGACTTACTTAAGACTATTTTAAGAAATAGAGATGT
1201 CATAGCCTGAAGATTTACTGAAGCTTCTGAACATGCCACCATGCCAAAGCTATGTTTCTCAAACCCAGCTCTGTGGATCA
1281 TGTTCCTAAAAGATGCTCATGGGGAGAAAATGTTTACAGACAAATAATTTTGGGAGCTGCCTTTGCAAACCTGCCTGTTG
1361 GCATATTGAAGGCTCTAAGAATTCCTTCACTAAATAACCCAGTTTTAATATATCCTTATCCAAAGAGAAACTCATTTTTT
1441 TAAAGTGAAATATTTGTTAACAGCCCATTGAACATACTTTTAAAAACACTATGGTAGAGAATGCTGTGTTGCCTTCTGGG
1521 CTGCATTTTTCTTATTGATTTGGAATTGTAACCTATGTATGAGAAAGGGATTTTCTGGTATTTTGGTGACGTTGTACATT
1601 GTCCCAGACTGTTTGTAAACATGAGGTCAGACATGTGTAAGGTAGACGCCTATGGCCACTGGCTTGACCACCTTGGAAGT
1681 CAATGACTATTTTGAGATGAAGTATTTAACTATGAATATCATGAAGGTTATTTAAAAATGTATTTATTTTATCTTTGGGG
1761 TTCAAACATTAAAAAAATTTACATAGGTGTAGTAACTCATTTCAAGGGAATAAATGCTGGATTAAAAAGTGTAAATTTTT
1841 CATGAGAATTTGGGACTAAATTGCTGAACCAATAAAGCTGAAGAGTTGCAACCTCTAGAGTCAAAAAAGGGATTGAAATG
1921 TTGTTGCAAATGTAAATGCTGGCAGTGCAGCTTGCTATACATGTAAGCCAAAATTGTTTTATAGAACAAGTGATCTATAT
2001 TGTTGTGATCATCATTTAGCTTAAGAAAGGCCAGAGCTGGGAGAGTAGCAAATGTTTTCTCATCTGCAGTGTATCAGCAG
2081 TTCTTGGGCTTCAGCTGCTGAATAGATAATAATTCTAATTGAACATAAATTACATGAACTCACATGTGAATGATAGATAT
2161 GTTACAATATTTCATTCCTGATGCAGAAAATCAGCTGTGGTTTTTATTATTAACCCTTTCTTTTTCAGTGGTTTTGGAAT
2241 TCTAGCTCTATTCCTCCTGGCTTAAAATTTGAGGGCATAGAATTCACAAGAGTTTTTGAAGAGTTCTGTCTATTCAGGCT
2321 TTCCTTTGTCCCCACCCTAGTGTCATTTTCACTCACTCCCATTTCTACACATAAGTATTAAAAAGGATGTATTTATTATA
2401 ATTCGCTAGTACTGATTGGTAAGCCTCATAATTGGCCTTTGTTATCTTTGTACTGTGACGAAGGCAGTGGATGATACATT
2481 ACCAATCATTGCCGAAGATAACCTCTTCTATCTTTTTGACCCAACTACCCTTATTAAAACTATCAGGTAAAATATTGGAG
2561 TTAGGTTTTTAAAGTCATTGGGCTGTGGCAGTGTGCTTAGAAAAGAAAATGGTGGAACATAGAATATTCTTTTGGTCACT
2641 ACACAATGTGTTACTTATACATGGCAGGGAAGGGAATTTTAAATCAAACTCGCAGTTTGGTTCTTAGGTCCTCTGCTGAT
2721 GAATTCTCGCTCTATCAGGGAATGATATGTGACGCCAGCCTTAGGAACCTGGTGTTCAACTGTAAATCTTTCTATTTAGC
2801 TTTTTGTATTAGTTGAATGAAGTTATAGAATATGAATTATTGAATACAGTTCTGTTCAGCCAATAGGCACTTGATATACA
2881 GAATGGTAAATTTAAATATAAATTAAATTTTTCTAATATTATGATCAGCACTTCACTGTGGTTCTGTGTCTTTAACCACC
2961 TCATAATAAGAACTGTTATTGAGGACTGGGCTACAGAATGTGCTTAGACTACATCTATGGCTTCCATAGATTTTAGTAAA
3041 ATTTAAACAGATAATTTGTGTTTACTGCTGATGTTACTTTAATATTGAATTAGTAGTTCATCCTGAGAGTTATATTTCAC
3121 AGAGGAAAATAACCAACAGCTGAAAACAACAATAATAAAGCTCTGGTGAGTCTGACTCATACTCGGAGAAAGTTTTTGGA
3201 ATACATACACATTTGGTGCATATAAGAGTTGGGTTTCCTTTTCCCACTTTCTGAGATGTACTAACCTCTGCCAGACCCTT
3281 AAATGATTTTGTTATGTTTTGCATTTTTGAGGCCAACCTTATTTTGTAACTGAAAAAAGTCCAGTTTTGCATACACAGAA
3361 ATTTGGTCATTTTAGAAGTCTCACAACCTGAATAATTTGATAATAATTGAATATGCTATTAACAGCTTTTTAAGAAAAGG
3441 TTCTATTAGTCAGTTTTTTCCTTGTCTGTCATATTATGTTGGTTAATGTCTCTTATGGCCAATCTTAGTAAACAGACCTA
3521 ACACTCACTGCATCCTTTTGTGCCTTACTTTTTACTTTCCTTTTGCCCTTTTGGTATGTGCGCATGTAAGATGGTAAGTT
3601 TAAGGCTAATGAATATATGTTTGTAATTTCCTACTCACTACTCTGCAGTTAAAGCTAAGGCCTTAGGCAAAATCTAGAAA
3681 TGTTTATATTGTTTTGTTTTTTATCAAGTGGTGTCAACTTGAGAAATACAAAGAAAGGCTATGCTTAACTGTATAACCGT
3761 GGGGGATTTTAGCCATGAGAATATGAAGCTGATGTCAGCCTGCTAACCTGTTTTACCAAAAGGAAAAGATGTTTCCAAAA
3841 ATGTTTTCGGTGTAGACTGTTTAAAGATGAAAATAAATTATATAATTTATTATATGAAATAAATTTTTGATAAGTCACTG
3921 ACAGTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUG-UCAACGGUCGACUCUAau 5'
            || |||||:: |:||||||  
Target 5' ttACTAGTTGTTTGTTGAGATgt 3'
 399 - 421 152.00 -16.90
2 
miRNA  3' agUGUCAACGGUCGACUCUAAu 5'
            | || |   | :||||||| 
Target 5' ttAAAGATAAGACTTGAGATTt 3'
 65 - 86 148.00 -6.90
3 
miRNA  3' agugucaACGGU-----CGACUCUAAu 5'
                 ||:||     ||||||:|| 
Target 5' cccaaaaTGTCATTAGTGCTGAGGTTg 3'
 667 - 693 139.00 -15.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
989877 6 ClinVar
348551 112 ClinVar
902753 223 ClinVar
348550 237 ClinVar
348549 253 ClinVar
348548 258 ClinVar
348547 271 ClinVar
902752 327 ClinVar
902751 328 ClinVar
902750 352 ClinVar
348546 354 ClinVar
348545 373 ClinVar
348544 420 ClinVar
348543 454 ClinVar
348542 455 ClinVar
348541 470 ClinVar
348540 610 ClinVar
348539 612 ClinVar
348538 638 ClinVar
348537 681 ClinVar
348536 807 ClinVar
901290 1008 ClinVar
901289 1031 ClinVar
348535 1041 ClinVar
901288 1122 ClinVar
348534 1574 ClinVar
901287 1591 ClinVar
348533 1614 ClinVar
348532 1620 ClinVar
348531 1622 ClinVar
348530 1635 ClinVar
900129 1637 ClinVar
900128 1648 ClinVar
900127 1659 ClinVar
348529 1727 ClinVar
348528 2123 ClinVar
348527 2179 ClinVar
348526 2209 ClinVar
348525 2250 ClinVar
348524 2300 ClinVar
902680 2480 ClinVar
902679 2618 ClinVar
348523 2645 ClinVar
348522 2694 ClinVar
348521 2708 ClinVar
348520 2840 ClinVar
901773 2871 ClinVar
901772 2916 ClinVar
901771 2921 ClinVar
901770 2966 ClinVar
348519 2990 ClinVar
348518 3082 ClinVar
348517 3134 ClinVar
348516 3234 ClinVar
348515 3402 ClinVar
348514 3408 ClinVar
348513 3775 ClinVar
348512 3848 ClinVar
901221 3870 ClinVar
COSN30161668 6 COSMIC
COSN22310933 9 COSMIC
COSN30534442 18 COSMIC
COSN31492837 24 COSMIC
COSN30136175 33 COSMIC
COSN26994269 35 COSMIC
COSN31580385 90 COSMIC
COSN26433850 134 COSMIC
COSN31962250 223 COSMIC
COSN25592779 304 COSMIC
COSN20217377 308 COSMIC
COSN14689357 490 COSMIC
COSN22205979 512 COSMIC
COSN31962249 774 COSMIC
COSN23282834 920 COSMIC
COSN16074314 1105 COSMIC
COSN9034676 2319 COSMIC
COSN28201076 2391 COSMIC
COSN20091025 3105 COSMIC
COSN16902755 3148 COSMIC
COSN29381098 3548 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1311339961 2 dbSNP
rs370913126 5 dbSNP
rs753956739 6 dbSNP
rs1333761633 7 dbSNP
rs1249766955 10 dbSNP
rs780083655 12 dbSNP
rs1165815479 21 dbSNP
rs1187630425 24 dbSNP
rs770981263 28 dbSNP
rs1377492864 31 dbSNP
rs1388092677 32 dbSNP
rs756670999 34 dbSNP
rs539180638 37 dbSNP
rs772786286 41 dbSNP
rs913911044 41 dbSNP
rs1381531474 42 dbSNP
rs988623277 45 dbSNP
rs1390261515 47 dbSNP
rs566908437 48 dbSNP
rs377381566 49 dbSNP
rs758928031 50 dbSNP
rs1463165047 52 dbSNP
rs1392778716 56 dbSNP
rs1030723980 61 dbSNP
rs999205440 62 dbSNP
rs890104512 65 dbSNP
rs969213302 70 dbSNP
rs1318956210 72 dbSNP
rs1342699830 80 dbSNP
rs1164564988 82 dbSNP
rs1283868980 89 dbSNP
rs1354540838 89 dbSNP
rs1225486973 100 dbSNP
rs1268861231 103 dbSNP
rs546485582 109 dbSNP
rs1421885635 110 dbSNP
rs886059353 112 dbSNP
rs1245949643 117 dbSNP
rs529864288 126 dbSNP
rs994723607 128 dbSNP
rs1236485951 130 dbSNP
rs1471614148 143 dbSNP
rs996484233 147 dbSNP
rs569336905 151 dbSNP
rs1448357024 191 dbSNP
rs897489312 200 dbSNP
rs1457166754 203 dbSNP
rs900372271 205 dbSNP
rs1404766501 207 dbSNP
rs1037942110 208 dbSNP
rs890238801 212 dbSNP
rs146860744 223 dbSNP
rs140928773 237 dbSNP
rs1411900902 237 dbSNP
rs1350011120 238 dbSNP
rs1227685205 247 dbSNP
rs1258932510 248 dbSNP
rs75428345 253 dbSNP
rs530705733 254 dbSNP
rs577008196 258 dbSNP
rs369036903 260 dbSNP
rs564585668 264 dbSNP
rs1440335536 269 dbSNP
rs544559197 271 dbSNP
rs745711818 276 dbSNP
rs1270799943 285 dbSNP
rs1251882391 286 dbSNP
rs1227498643 308 dbSNP
rs930000394 310 dbSNP
rs1179436290 327 dbSNP
rs796305783 328 dbSNP
rs1467013531 332 dbSNP
rs1172287925 337 dbSNP
rs982416862 338 dbSNP
rs1431844933 349 dbSNP
rs1304205484 353 dbSNP
rs572862359 354 dbSNP
rs948304880 355 dbSNP
rs1408034266 363 dbSNP
rs143987218 373 dbSNP
rs1293148029 382 dbSNP
rs535603321 386 dbSNP
rs1332689070 402 dbSNP
rs1443468888 404 dbSNP
rs916801138 408 dbSNP
rs989656851 413 dbSNP
rs1274016826 419 dbSNP
rs886059352 420 dbSNP
rs988188750 424 dbSNP
rs1167282341 434 dbSNP
rs559367534 449 dbSNP
rs1482539393 451 dbSNP
rs77936887 454 dbSNP
rs73252520 455 dbSNP
rs886059351 470 dbSNP
rs1175024249 474 dbSNP
rs553192943 476 dbSNP
rs777741421 477 dbSNP
rs1198847016 478 dbSNP
rs555183429 483 dbSNP
rs377326361 485 dbSNP
rs143460296 486 dbSNP
rs977819601 486 dbSNP
rs1188253630 487 dbSNP
rs969163043 487 dbSNP
rs1391617649 490 dbSNP
rs1387258702 492 dbSNP
rs186113758 498 dbSNP
rs1452015553 501 dbSNP
rs1030403527 504 dbSNP
rs1230283851 514 dbSNP
rs1027481085 515 dbSNP
rs1340934325 527 dbSNP
rs995817526 528 dbSNP
rs1224868835 539 dbSNP
rs1428063903 541 dbSNP
rs900425469 544 dbSNP
rs576003740 560 dbSNP
rs1266681200 563 dbSNP
rs1488548330 564 dbSNP
rs756048925 584 dbSNP
rs558992664 589 dbSNP
rs1481500005 591 dbSNP
rs1230912934 596 dbSNP
rs1204385992 603 dbSNP
rs570766273 610 dbSNP
rs886059350 612 dbSNP
rs1282354845 618 dbSNP
rs538981451 622 dbSNP
rs1447875701 625 dbSNP
rs566865594 627 dbSNP
rs1047160017 634 dbSNP
rs767422475 636 dbSNP
rs10004441 638 dbSNP
rs906576188 642 dbSNP
rs536327033 647 dbSNP
rs1457439145 651 dbSNP
rs1300854633 658 dbSNP
rs1392134300 660 dbSNP
rs567495043 664 dbSNP
rs890134795 665 dbSNP
rs948047044 666 dbSNP
rs1364263177 668 dbSNP
rs916832875 669 dbSNP
rs1380145452 675 dbSNP
rs76926200 681 dbSNP
rs765451140 686 dbSNP
rs762057798 701 dbSNP
rs1306521770 708 dbSNP
rs1243369867 712 dbSNP
rs1270741688 715 dbSNP
rs936848406 731 dbSNP
rs1331834339 742 dbSNP
rs776918794 749 dbSNP
rs1247770285 757 dbSNP
rs1376652887 758 dbSNP
rs899992362 762 dbSNP
rs1183992754 769 dbSNP
rs182267086 774 dbSNP
rs1423471504 775 dbSNP
rs1162793643 776 dbSNP
rs954616302 777 dbSNP
rs1414371849 781 dbSNP
rs1458741504 800 dbSNP
rs1030047343 805 dbSNP
rs1387598800 806 dbSNP
rs13109061 807 dbSNP
rs1304397344 810 dbSNP
rs964384558 812 dbSNP
rs1395161583 818 dbSNP
rs892690978 821 dbSNP
rs1420459786 822 dbSNP
rs939328007 828 dbSNP
rs1268008645 835 dbSNP
rs1016157943 836 dbSNP
rs1475405463 837 dbSNP
rs1259615643 838 dbSNP
rs1212609786 841 dbSNP
rs1256954898 844 dbSNP
rs1006080032 846 dbSNP
rs1483047799 853 dbSNP
rs1208559165 859 dbSNP
rs886306143 867 dbSNP
rs550980090 876 dbSNP
rs1472983783 894 dbSNP
rs1407099386 896 dbSNP
rs1398896252 902 dbSNP
rs980817515 904 dbSNP
rs1219133190 914 dbSNP
rs1255441650 935 dbSNP
rs1488758808 936 dbSNP
rs948180614 938 dbSNP
rs1216817849 943 dbSNP
rs1310737046 946 dbSNP
rs761089080 949 dbSNP
rs1026099676 952 dbSNP
rs1409847612 955 dbSNP
rs775968559 957 dbSNP
rs149819105 971 dbSNP
rs1302402223 975 dbSNP
rs1312031503 988 dbSNP
rs772493230 1002 dbSNP
rs1276990928 1003 dbSNP
rs1483518615 1007 dbSNP
rs375166577 1008 dbSNP
rs1231254813 1010 dbSNP
rs1468523192 1019 dbSNP
rs1192900327 1022 dbSNP
rs962198529 1023 dbSNP
rs1295666508 1026 dbSNP
rs559066856 1031 dbSNP
rs1171547601 1035 dbSNP
rs1391568785 1036 dbSNP
rs987794756 1040 dbSNP
rs114420733 1041 dbSNP
rs1454873329 1046 dbSNP
rs1386074989 1047 dbSNP
rs1352326397 1054 dbSNP
rs189623091 1055 dbSNP
rs1439198639 1059 dbSNP
rs1294675691 1061 dbSNP
rs1029109649 1065 dbSNP
rs1232490011 1067 dbSNP
rs1300285632 1068 dbSNP
rs112490189 1069 dbSNP
rs1228030056 1074 dbSNP
rs1461774764 1075 dbSNP
rs968478686 1076 dbSNP
rs1453440577 1087 dbSNP
rs528969191 1088 dbSNP
rs567988433 1112 dbSNP
rs185604480 1118 dbSNP
rs770577255 1122 dbSNP
rs1247162351 1128 dbSNP
rs924145539 1139 dbSNP
rs1467986593 1147 dbSNP
rs1021398308 1161 dbSNP
rs1042586434 1163 dbSNP
rs1391853166 1166 dbSNP
rs933475776 1185 dbSNP
rs923030964 1191 dbSNP
rs1416739775 1197 dbSNP
rs1406562939 1223 dbSNP
rs748952510 1234 dbSNP
rs548248998 1255 dbSNP
rs1052669189 1257 dbSNP
rs1004238318 1265 dbSNP
rs1322964752 1276 dbSNP
rs1187238912 1281 dbSNP
rs544768344 1285 dbSNP
rs908872759 1287 dbSNP
rs984709044 1288 dbSNP
rs1358764911 1299 dbSNP
rs1228902183 1303 dbSNP
rs950640823 1311 dbSNP
rs1334060533 1319 dbSNP
rs1026156948 1331 dbSNP
rs1211798326 1332 dbSNP
rs1249643052 1335 dbSNP
rs762253134 1342 dbSNP
rs1192247154 1343 dbSNP
rs576015991 1354 dbSNP
rs1239957332 1362 dbSNP
rs1037767521 1363 dbSNP
rs1181868253 1364 dbSNP
rs1275394047 1376 dbSNP
rs181160877 1392 dbSNP
rs140023624 1400 dbSNP
rs1340453076 1402 dbSNP
rs1025504850 1408 dbSNP
rs1316697588 1409 dbSNP
rs1342416703 1431 dbSNP
rs777651628 1434 dbSNP
rs1353692341 1435 dbSNP
rs1231350838 1442 dbSNP
rs1269902762 1465 dbSNP
rs1221483821 1467 dbSNP
rs1383481358 1474 dbSNP
rs573217542 1481 dbSNP
rs1319488964 1483 dbSNP
rs1443782704 1487 dbSNP
rs1210458632 1491 dbSNP
rs1053785231 1497 dbSNP
rs1256156364 1500 dbSNP
rs1000834718 1501 dbSNP
rs1183742893 1511 dbSNP
rs954828781 1513 dbSNP
rs755959080 1518 dbSNP
rs1157185201 1519 dbSNP
rs902781054 1526 dbSNP
rs1042619663 1532 dbSNP
rs1441125392 1534 dbSNP
rs933508048 1535 dbSNP
rs1312546299 1540 dbSNP
rs921579689 1541 dbSNP
rs1411688218 1542 dbSNP
rs1457201980 1559 dbSNP
rs192072915 1563 dbSNP
rs1238328165 1566 dbSNP
rs886059349 1574 dbSNP
rs36042550 1575 dbSNP
rs1211369330 1582 dbSNP
rs751678209 1591 dbSNP
rs1206592926 1596 dbSNP
rs1484492213 1596 dbSNP
rs536799913 1598 dbSNP
rs151120379 1614 dbSNP
rs1009999178 1617 dbSNP
rs886059348 1620 dbSNP
rs886059347 1622 dbSNP
rs1379698513 1628 dbSNP
rs372426498 1632 dbSNP
rs886059346 1635 dbSNP
rs956889300 1635 dbSNP
rs781169592 1637 dbSNP
rs1041118552 1642 dbSNP
rs186793648 1645 dbSNP
rs1431870271 1647 dbSNP
rs117876262 1648 dbSNP
rs971667414 1652 dbSNP
rs1356086552 1659 dbSNP
rs1326723179 1666 dbSNP
rs1252411895 1672 dbSNP
rs1332782533 1675 dbSNP
rs1234675668 1678 dbSNP
rs571230740 1683 dbSNP
rs551684417 1690 dbSNP
rs899172385 1694 dbSNP
rs1012785879 1697 dbSNP
rs1338221756 1698 dbSNP
rs940805007 1708 dbSNP
rs372016412 1710 dbSNP
rs959447337 1715 dbSNP
rs1270038863 1722 dbSNP
rs886059345 1727 dbSNP
rs1440968778 1733 dbSNP
rs1193326021 1750 dbSNP
rs1052057086 1753 dbSNP
rs1169517148 1760 dbSNP
rs1372547391 1761 dbSNP
rs1372789703 1761 dbSNP
rs1460485563 1771 dbSNP
rs1165087457 1778 dbSNP
rs34922539 1778 dbSNP
rs1000885580 1782 dbSNP
rs528362524 1783 dbSNP
rs1321165614 1786 dbSNP
rs1043060724 1789 dbSNP
rs997768900 1804 dbSNP
rs1386010401 1805 dbSNP
rs921823429 1808 dbSNP
rs1224544116 1810 dbSNP
rs902047473 1816 dbSNP
rs1396868485 1820 dbSNP
rs974661758 1825 dbSNP
rs1039204631 1826 dbSNP
rs914276615 1830 dbSNP
rs1466561781 1833 dbSNP
rs1187493963 1834 dbSNP
rs1261229514 1839 dbSNP
rs750476628 1842 dbSNP
rs1189699285 1843 dbSNP
rs1389443974 1851 dbSNP
rs1461872300 1852 dbSNP
rs1164171998 1853 dbSNP
rs1392236978 1854 dbSNP
rs1458576718 1867 dbSNP
rs765240402 1868 dbSNP
rs956008695 1879 dbSNP
rs1360758990 1895 dbSNP
rs1285958291 1897 dbSNP
rs375113598 1898 dbSNP
rs1380240386 1900 dbSNP
rs564521309 1903 dbSNP
rs1314233219 1904 dbSNP
rs1031158166 1905 dbSNP
rs1454753145 1911 dbSNP
rs982658049 1915 dbSNP
rs970885975 1920 dbSNP
rs1023802576 1929 dbSNP
rs1379656361 1944 dbSNP
rs761969902 1945 dbSNP
rs1260574933 1947 dbSNP
rs1196943683 1958 dbSNP
rs1202446383 1962 dbSNP
rs1258273182 1980 dbSNP
rs1244872372 1993 dbSNP
rs1451408083 1996 dbSNP
rs1185922853 1999 dbSNP
rs1012459794 2000 dbSNP
rs1048776786 2001 dbSNP
rs1159564719 2006 dbSNP
rs1344451718 2029 dbSNP
rs565707576 2041 dbSNP
rs548696687 2044 dbSNP
rs1251631476 2047 dbSNP
rs929000192 2050 dbSNP
rs1413566173 2054 dbSNP
rs34960502 2059 dbSNP
rs899162614 2061 dbSNP
rs367982750 2071 dbSNP
rs1224882680 2073 dbSNP
rs1274529056 2087 dbSNP
rs1315543238 2090 dbSNP
rs181662715 2092 dbSNP
rs754048905 2096 dbSNP
rs915775945 2098 dbSNP
rs1485477252 2107 dbSNP
rs991350533 2119 dbSNP
rs142960382 2123 dbSNP
rs764370119 2126 dbSNP
rs1032451065 2129 dbSNP
rs979498269 2130 dbSNP
rs1272727543 2132 dbSNP
rs1051876385 2147 dbSNP
rs190475638 2158 dbSNP
rs1417044565 2159 dbSNP
rs531097603 2169 dbSNP
rs886059344 2179 dbSNP
rs1433785015 2180 dbSNP
rs902099485 2183 dbSNP
rs1336158781 2188 dbSNP
rs1443518603 2192 dbSNP
rs947327495 2197 dbSNP
rs914224170 2204 dbSNP
rs9998044 2209 dbSNP
rs775764791 2212 dbSNP
rs1347426917 2213 dbSNP
rs1407740839 2215 dbSNP
rs887930821 2220 dbSNP
rs1276841118 2239 dbSNP
rs111725130 2244 dbSNP
rs1048828455 2245 dbSNP
rs1325398875 2250 dbSNP
rs886059343 2250 dbSNP
rs1479619363 2251 dbSNP
rs545718338 2264 dbSNP
rs1253454571 2267 dbSNP
rs1275881598 2268 dbSNP
rs573455408 2271 dbSNP
rs1171403680 2273 dbSNP
rs1023791209 2276 dbSNP
rs768015164 2277 dbSNP
rs897524522 2285 dbSNP
rs1169147175 2286 dbSNP
rs1045406451 2294 dbSNP
rs1353201941 2295 dbSNP
rs949717446 2298 dbSNP
rs184832870 2300 dbSNP
rs1435423802 2303 dbSNP
rs1326986803 2305 dbSNP
rs1370791155 2309 dbSNP
rs1404374502 2318 dbSNP
rs991029363 2327 dbSNP
rs1362948675 2328 dbSNP
rs1214001892 2330 dbSNP
rs915847628 2335 dbSNP
rs991385274 2339 dbSNP
rs559495967 2353 dbSNP
rs935848731 2365 dbSNP
rs1364573036 2371 dbSNP
rs1191533972 2372 dbSNP
rs1016253389 2378 dbSNP
rs1475538402 2385 dbSNP
rs1185430622 2386 dbSNP
rs370574629 2387 dbSNP
rs891466451 2388 dbSNP
rs979549038 2388 dbSNP
rs997635068 2398 dbSNP
rs966784536 2404 dbSNP
rs1251819243 2405 dbSNP
rs1021422195 2408 dbSNP
rs1268469281 2412 dbSNP
rs1038910837 2413 dbSNP
rs947276585 2420 dbSNP
rs1293772523 2427 dbSNP
rs1334083939 2444 dbSNP
rs1211516769 2448 dbSNP
rs759988847 2450 dbSNP
rs1447206524 2454 dbSNP
rs893032638 2459 dbSNP
rs773844487 2460 dbSNP
rs1475879586 2463 dbSNP
rs976124319 2467 dbSNP
rs1188074796 2471 dbSNP
rs1417703530 2478 dbSNP
rs966419399 2480 dbSNP
rs1017882308 2485 dbSNP
rs1007754743 2488 dbSNP
rs887981454 2494 dbSNP
rs1027777244 2506 dbSNP
rs1226419725 2510 dbSNP
rs1312354760 2512 dbSNP
rs763239519 2524 dbSNP
rs1242593534 2526 dbSNP
rs993587839 2529 dbSNP
rs545972767 2537 dbSNP
rs1403955495 2554 dbSNP
rs139877142 2555 dbSNP
rs180999105 2557 dbSNP
rs1281639374 2568 dbSNP
rs1486456612 2575 dbSNP
rs1013944064 2578 dbSNP
rs532355223 2580 dbSNP
rs770577926 2585 dbSNP
rs537128743 2591 dbSNP
rs916728388 2605 dbSNP
rs1270796497 2619 dbSNP
rs1332323068 2620 dbSNP
rs1364911050 2621 dbSNP
rs147447027 2625 dbSNP
rs1157201088 2629 dbSNP
rs1397045388 2638 dbSNP
rs143152362 2645 dbSNP
rs1173077743 2659 dbSNP
rs188258593 2663 dbSNP
rs1161651748 2665 dbSNP
rs367555067 2691 dbSNP
rs1394189505 2692 dbSNP
rs956925 2694 dbSNP
rs886059342 2708 dbSNP
rs1189307151 2726 dbSNP
rs1041579773 2728 dbSNP
rs1030372808 2729 dbSNP
rs558259329 2742 dbSNP
rs140813857 2753 dbSNP
rs964820503 2754 dbSNP
rs1197059446 2759 dbSNP
rs1447073999 2760 dbSNP
rs976556890 2761 dbSNP
rs1269631642 2763 dbSNP
rs1017717668 2765 dbSNP
rs747903245 2771 dbSNP
rs966103268 2778 dbSNP
rs910537653 2780 dbSNP
rs1255345906 2783 dbSNP
rs1454857970 2786 dbSNP
rs1328249197 2800 dbSNP
rs1393540450 2806 dbSNP
rs986385870 2808 dbSNP
rs1011393972 2826 dbSNP
rs952300917 2830 dbSNP
rs144070806 2840 dbSNP
rs1329030763 2845 dbSNP
rs993640615 2853 dbSNP
rs906858353 2857 dbSNP
rs1045424258 2858 dbSNP
rs1329005913 2859 dbSNP
rs747587366 2863 dbSNP
rs948458979 2864 dbSNP
rs962503074 2866 dbSNP
rs915632823 2867 dbSNP
rs1365940648 2868 dbSNP
rs1275406751 2870 dbSNP
rs1469158777 2874 dbSNP
rs543762811 2876 dbSNP
rs1014413629 2881 dbSNP
rs1251310683 2885 dbSNP
rs1430526748 2895 dbSNP
rs548971111 2896 dbSNP
rs1388139562 2905 dbSNP
rs1372637281 2906 dbSNP
rs1166161334 2915 dbSNP
rs2286987 2919 dbSNP
rs1407421050 2921 dbSNP
rs894180119 2924 dbSNP
rs1412348513 2928 dbSNP
rs1055469522 2931 dbSNP
rs1475024007 2934 dbSNP
rs1038103623 2945 dbSNP
rs1396624033 2960 dbSNP
rs942170048 2963 dbSNP
rs115116065 2966 dbSNP
rs1388123463 2967 dbSNP
rs904452696 2969 dbSNP
rs1041635342 2972 dbSNP
rs951021974 2979 dbSNP
rs569788310 2987 dbSNP
rs555513125 2990 dbSNP
rs922417684 3004 dbSNP
rs1289137281 3008 dbSNP
rs964727640 3017 dbSNP
rs1343018422 3023 dbSNP
rs1486965464 3027 dbSNP
rs1299960082 3030 dbSNP
rs1261336870 3032 dbSNP
rs549929027 3035 dbSNP
rs1017660315 3036 dbSNP
rs1487320744 3044 dbSNP
rs1226216207 3046 dbSNP
rs1419851550 3047 dbSNP
rs1011673181 3050 dbSNP
rs1040498743 3051 dbSNP
rs957422188 3058 dbSNP
rs777130834 3062 dbSNP
rs1366547143 3069 dbSNP
rs1454996442 3071 dbSNP
rs1289048682 3072 dbSNP
rs1364752765 3076 dbSNP
rs886059341 3082 dbSNP
rs944784846 3084 dbSNP
rs1294273804 3085 dbSNP
rs533043851 3086 dbSNP
rs371492244 3093 dbSNP
rs1311004362 3109 dbSNP
rs1323537084 3110 dbSNP
rs1410987208 3112 dbSNP
rs1392525775 3133 dbSNP
rs886059340 3134 dbSNP
rs1448288005 3137 dbSNP
rs1240232029 3148 dbSNP
rs1260300921 3152 dbSNP
rs1487431201 3153 dbSNP
rs1031542062 3154 dbSNP
rs1213104493 3154 dbSNP
rs184343617 3160 dbSNP
rs1192563529 3169 dbSNP
rs1487413798 3174 dbSNP
rs1254035942 3179 dbSNP
rs986104229 3184 dbSNP
rs1420605994 3186 dbSNP
rs1159581972 3198 dbSNP
rs1245886256 3205 dbSNP
rs551637494 3234 dbSNP
rs192724241 3251 dbSNP
rs972711870 3256 dbSNP
rs1375577689 3257 dbSNP
rs1414675406 3260 dbSNP
rs1301551075 3263 dbSNP
rs1045636344 3277 dbSNP
rs1392256904 3283 dbSNP
rs1306816167 3291 dbSNP
rs1012512862 3294 dbSNP
rs1281088123 3300 dbSNP
rs894153449 3303 dbSNP
rs1203119516 3316 dbSNP
rs559763548 3318 dbSNP
rs1254113486 3320 dbSNP
rs543032293 3324 dbSNP
rs1341542693 3328 dbSNP
rs539888431 3339 dbSNP
rs1237407022 3362 dbSNP
rs1221134104 3374 dbSNP
rs769145141 3377 dbSNP
rs992969462 3385 dbSNP
rs1195157455 3389 dbSNP
rs887926682 3401 dbSNP
rs149506792 3402 dbSNP
rs188090390 3407 dbSNP
rs886059339 3408 dbSNP
rs377749470 3409 dbSNP
rs1297940566 3416 dbSNP
rs1375197165 3418 dbSNP
rs879443568 3432 dbSNP
rs757327984 3445 dbSNP
rs1370551367 3452 dbSNP
rs904173688 3453 dbSNP
rs1275288478 3454 dbSNP
rs1428618862 3456 dbSNP
rs552610277 3463 dbSNP
rs1257161507 3466 dbSNP
rs1456249620 3475 dbSNP
rs1177847762 3476 dbSNP
rs1431129939 3479 dbSNP
rs1423973169 3488 dbSNP
rs577710771 3492 dbSNP
rs1010564835 3495 dbSNP
rs185223774 3496 dbSNP
rs1421085719 3508 dbSNP
rs1473413337 3509 dbSNP
rs1170539600 3524 dbSNP
rs943314781 3527 dbSNP
rs910588508 3528 dbSNP
rs1249614479 3530 dbSNP
rs1041279200 3532 dbSNP
rs1181348277 3551 dbSNP
rs990228817 3555 dbSNP
rs1271983761 3562 dbSNP
rs1362801152 3566 dbSNP
rs942514530 3573 dbSNP
rs889212420 3574 dbSNP
rs1050448118 3581 dbSNP
rs930672666 3582 dbSNP
rs1234896422 3590 dbSNP
rs977252125 3613 dbSNP
rs1450663919 3614 dbSNP
rs534475915 3617 dbSNP
rs1243518084 3619 dbSNP
rs972381990 3623 dbSNP
rs1192319895 3626 dbSNP
rs193049643 3629 dbSNP
rs555343690 3631 dbSNP
rs940942535 3633 dbSNP
rs1256633399 3636 dbSNP
rs1476511828 3647 dbSNP
rs917470954 3654 dbSNP
rs774958208 3657 dbSNP
rs1413592845 3662 dbSNP
rs1403787673 3664 dbSNP
rs993415653 3667 dbSNP
rs1346038296 3669 dbSNP
rs1399406558 3672 dbSNP
rs138016872 3686 dbSNP
rs1012819905 3692 dbSNP
rs1235108000 3697 dbSNP
rs796405525 3711 dbSNP
rs1034122280 3713 dbSNP
rs1226419580 3734 dbSNP
rs569703028 3738 dbSNP
rs1278107044 3756 dbSNP
rs549793903 3758 dbSNP
rs1048859998 3759 dbSNP
rs894143569 3764 dbSNP
rs1486930032 3767 dbSNP
rs1409724716 3774 dbSNP
rs115004931 3775 dbSNP
rs1304107289 3777 dbSNP
rs968408741 3781 dbSNP
rs1020370750 3792 dbSNP
rs931611726 3803 dbSNP
rs112838702 3806 dbSNP
rs1009866484 3815 dbSNP
rs1408975670 3816 dbSNP
rs901093794 3818 dbSNP
rs1458672899 3822 dbSNP
rs1377393055 3828 dbSNP
rs1047272413 3842 dbSNP
rs1334679495 3842 dbSNP
rs1181417114 3847 dbSNP
rs111294195 3848 dbSNP
rs902017403 3849 dbSNP
rs1258120743 3854 dbSNP
rs918837212 3855 dbSNP
rs1040639810 3858 dbSNP
rs1377168207 3861 dbSNP
rs1239042749 3862 dbSNP
rs187861688 3870 dbSNP
rs1237184543 3875 dbSNP
rs112431959 3882 dbSNP
rs889602195 3883 dbSNP
rs1278469343 3891 dbSNP
rs1441257776 3892 dbSNP
rs771751503 3894 dbSNP
rs1233862527 3895 dbSNP
rs1439279496 3899 dbSNP
rs1176957980 3900 dbSNP
rs1050504252 3904 dbSNP
rs1172073008 3908 dbSNP
rs1331714815 3909 dbSNP
rs1266665553 3910 dbSNP
rs1228119754 3914 dbSNP
rs930726462 3915 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agugucaacggUCGACUCUAAu 5'
                     | :||||||| 
Target 5' ------auaagACUUGAGAUUu 3'
 		1 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000302922.3 | 3UTR | AUAAGACUUGAGAUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21849 B cell lymphoma -0.366 2.5e-2 -0.152 2.2e-1 29 Click to see details
GSE19350 CNS germ cell tumors -0.539 3.5e-2 -0.019 4.8e-1 12 Click to see details
GSE14794 Lymphoblastoid cells -0.19 3.6e-2 -0.111 1.5e-1 90 Click to see details
GSE26953 Aortic valvular endothelial cells -0.362 4.1e-2 -0.280 9.3e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.287 9.2e-2 0.352 5.0e-2 23 Click to see details
GSE38226 Liver fibrosis 0.26 1.3e-1 0.181 2.2e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.22 1.5e-1 -0.056 4.0e-1 25 Click to see details
GSE27834 Pluripotent stem cells 0.217 2.1e-1 0.085 3.8e-1 16 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.149 2.7e-1 -0.600 2.6e-3 20 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.12 2.8e-1 0.417 1.9e-2 25 Click to see details
GSE28260 Renal cortex and medulla -0.146 3.2e-1 -0.081 4.0e-1 13 Click to see details
GSE21687 Ependynoma primary tumors 0.032 4.0e-1 -0.047 3.6e-1 64 Click to see details
GSE28544 Breast cancer 0.012 4.8e-1 0.062 3.9e-1 24 Click to see details
GSE17306 Multiple myeloma -0.007 4.8e-1 0.377 3.8e-3 49 Click to see details
GSE32688 Pancreatic cancer -0.004 4.9e-1 0.016 4.7e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC 0.359 0.01 0.343 0.01 45 Click to see details
THCA 0.289 0.02 0.219 0.07 47 Click to see details
ESCA 0.897 0.05 0.800 0.1 4 Click to see details
BRCA 0.248 0.12 0.223 0.14 25 Click to see details
KICH 0.376 0.13 0.391 0.12 11 Click to see details
KIRP 0.268 0.14 0.174 0.24 18 Click to see details
LUSC -0.229 0.17 -0.287 0.11 20 Click to see details
HNSC -0.194 0.19 -0.102 0.32 23 Click to see details
PRAD 0.151 0.21 0.022 0.45 31 Click to see details
PAAD -0.489 0.26 -0.400 0.3 4 Click to see details
KIRC 0.081 0.34 0.135 0.24 29 Click to see details
STAD 0.049 0.42 0.006 0.49 20 Click to see details
BLCA -0.073 0.42 0.042 0.45 10 Click to see details
UCEC 0.038 0.46 0.103 0.39 10 Click to see details
LUAD 0.03 0.47 -0.283 0.23 9 Click to see details
CHOL -0.001 0.5 -0.095 0.41 8 Click to see details
CHOL -0.001 0.5 -0.095 0.41 8 Click to see details
CHOL -0.001 0.5 -0.095 0.41 8 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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