pre-miRNA Information
pre-miRNA hsa-mir-4666a   
Genomic Coordinates chr1: 228462074 - 228462152
Description Homo sapiens miR-4666a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4666a-5p
Sequence 10| AUACAUGUCAGAUUGUAUGCC |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1288210208 3 dbSNP
rs1333314792 5 dbSNP
rs562096649 7 dbSNP
rs1324809033 10 dbSNP
rs1027635037 13 dbSNP
rs1351630778 15 dbSNP
rs1034879562 18 dbSNP
rs1383267208 21 dbSNP
Putative Targets

Gene Information
Gene Symbol RPH3A   
Synonyms -
Description rabphilin 3A
Transcript NM_001143854   
Other Transcripts NM_014954   
Expression
Putative miRNA Targets on RPH3A
3'UTR of RPH3A
(miRNA target sites are highlighted)
>RPH3A|NM_001143854|3'UTR
   1 GCTAGTGCCCAGGTCCCCATCTCCATGTCCCGGGTCCCCCCCAGCCTGCTCTAGCTGCCCACCGCACCCTGATCTCTCTT
  81 CTCTATGCCTACCTCCCCCCATACCCTGCTGATCTCCCTGAGCCTGCCTTTGAGCCCCCGTCACGTTGGGCACTGCTGCC
 161 AAAGACTCCCTCCTCCCTGATGCTGGGATGTGGGCTCTGAATACAGCCCCTCTCTCATCCCTGGGATGGAGCAATGGGGA
 241 TGGGGTTGGGGAGACGTTTACAAAGAGGTTGATCATTTAATAACCTCTCAGTTTGGGTAAATTACAAAGGTTCTTCATCA
 321 TTTAGGACTGTTTTTAGACCCTCCTAGCCTTGAACACACACATGTACACACACACACACACACACACACACACACCCTTT
 401 CATTCCCTGTGTTGTGTCTCTGTATATCCCCAGTTGTCAGCAGACCCGGACAATGCTGTGAGAGAAGCATTGGGGCACAA
 481 ATAGAGCCTCCGGGCTCCCACTGCCCCCTGAGATGTACACCCTGATTGCCAGGAAAACAGACTGCTGTGTTCAGTAACAC
 561 ACCCTCCCTGCTCCAAGTGCACCAGGATGCAAATGCACAGAATTCACCAGGGGCTTGGACGCTCTCCTCTTTCCGAATGT
 641 CACCTGTGTGCTTCCTAGCAAAACAAAAACAAACGACAACAACAAAAAACCCTTCCTCTGTCACCTTTTCTCCTCCTCCC
 721 TCTTCTTTCCCTTCCATGATAGTAGATTCTCTCTTTCTCAGCCTCTCCCCTCTCCTTTCTCTCCCTGCCTTTCTTCCCTT
 801 TGCCTTTCTCTCTCTCTAAAGCAGTAACACCGCAAAAACAACAGCAAAAAAAGTGTATGTTAACCTAGCCTCACCCCCTT
 881 GCTCTCACCAGCCTGACCAGGAAACTGAGAAACTGGCCCAAACCTGAGATTCCACTTGGGCCCACGCTTCTTAACTGACC
 961 CACTCCTCCCGTTGGCAGAACCAGACATTCCCAGGGCTTGGGCCAATGGCTGGCACTGCCCTGAGTGCATGGCAGCATCC
1041 CTCAAGCTGTGTAGATGCCCCATAGAGGACTCTCTCATCCGTGGGCTCCCCGGGTGGGCACGGAGGCATTTAGAAGACCA
1121 GGGCCATGGGTCTGAGGAAGCCTCAGCCAAAGCCTCCAGCCTTTCTCCTTTCTCCGCTCTTAGGTAAATGAACAAGCTAC
1201 CCTCCTCCCCAATGCCCTTGACTCTGTTTCATTGACTCTTTTGCATCCCATCTCTCACTCAGAACCCCCTCCAGTCTCTC
1281 TGTCTCTCTTTGTCTGTCTCTCTGTCTCCTGCACTCTCGTTACTAAGCTTCCTGGGAGAATCAAATAATATCATGGCTAT
1361 GGAACAGTAGAGAGAGACAGGCCTGATGCCAAAGGCTTTGGGCTCATCATCAATCTTTCACTTTCTTCCTATAAAAAAAA
1441 TTATTTTATAAAGGAGGAAAAGGCAATGTGGGCAAACATTACAAATTTGAGGTTGAAGTCAGGCAATCTTCAATGCCCTG
1521 TGAGAAAGGTTCGATTTTCCCAATTTTGATGAAGTCTTCCCTCATGAAAATCACTCCCAGTCATCCCAAACCCCTGACAT
1601 TCTCTACAGAAGCATCAGACAGATACTCAAACTCTCACTTTCCCCAAATCACATCTCTTAACTTTTCAACGCCCTCCACC
1681 CTCAGCTCCCTGCACAATTCATGGGAGGACTCATTTCTTGCCTTGAATAACCATTTTCTAAACATCGAGCTCTTCACCTT
1761 CCCCAAGGTGGCCAACAGCTTCCTGGCTGCCATCTTTCCTTTTGACCTTATCTTTCCCCATTAGTCCCTGGTGGCACCTA
1841 CTCTCAGCCCACCTCCCTCACCACAGTTTCCCCTTAGGAGACAGCATGCTGGCTGTGTCGCCCAAGCCTGATGCTGGTGT
1921 AGGCGCTGGAATCAGCATGCAGCAAGCTCACAGTGCCCCTAGTCTGGGTGCCCGCTGTCCCCGACAAATGTAACCACCTC
2001 CCTGCCTAGAATACACACACGTCCTCCGGTGCATGCACAACCACCCAGCATCTTTCTTTGTGATGATGTAGCCAAAAATA
2081 AAGTAGGAGCATCCAAGAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ccguaUGUUAGACUGUACAUa 5'
               |||  |  ||||||| 
Target 5' cttgaACA--CACACATGTAc 3'
349 - 367 144.00 -5.10
2
miRNA  3' ccGU-AUGUUAGACUGUACAUa 5'
            || |:|   |||| ||||| 
Target 5' ccCACTGCCCCCTGAGATGTAc 3'
497 - 518 127.00 -9.30
3
miRNA  3' ccGUAUGUUAGACUG-UACAUa 5'
            | | |  | |||: ||||| 
Target 5' atCTTTCTTTGTGATGATGTAg 3'
2050 - 2071 107.00 -5.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31503935 13 COSMIC
COSN30107739 14 COSMIC
COSN30480774 17 COSMIC
COSN30165410 19 COSMIC
COSN30473770 37 COSMIC
COSN1142423 43 COSMIC
COSN22792607 43 COSMIC
COSN31499590 46 COSMIC
COSN30538396 66 COSMIC
COSN30156518 72 COSMIC
COSN30128999 82 COSMIC
COSN30102958 83 COSMIC
COSN30447452 96 COSMIC
COSN30184748 98 COSMIC
COSN30472898 106 COSMIC
COSN30109274 390 COSMIC
COSN20110135 391 COSMIC
COSN20110134 395 COSMIC
COSN19518868 449 COSMIC
COSN25553168 676 COSMIC
COSN29712578 790 COSMIC
COSN7310582 1239 COSMIC
COSN22303729 1653 COSMIC
COSN16050887 1671 COSMIC
COSN15126085 1772 COSMIC
COSN24716374 1926 COSMIC
COSN5930704 2022 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1167799430 2 dbSNP
rs778700580 3 dbSNP
rs745677627 10 dbSNP
rs1171743898 11 dbSNP
rs560525100 12 dbSNP
rs780192808 13 dbSNP
rs557856340 20 dbSNP
rs1236537163 23 dbSNP
rs1340804181 24 dbSNP
rs1429963608 26 dbSNP
rs111547560 27 dbSNP
rs1276160501 28 dbSNP
rs746491230 30 dbSNP
rs370051177 32 dbSNP
rs374264060 33 dbSNP
rs761471927 35 dbSNP
rs768540113 36 dbSNP
rs776448696 36 dbSNP
rs572557744 37 dbSNP
rs774737920 38 dbSNP
rs183030298 39 dbSNP
rs767979590 42 dbSNP
rs377023105 43 dbSNP
rs764101830 46 dbSNP
rs377081104 47 dbSNP
rs1163951885 59 dbSNP
rs919998027 60 dbSNP
rs984266773 64 dbSNP
rs531358766 65 dbSNP
rs1470590944 70 dbSNP
rs969134038 71 dbSNP
rs549787722 75 dbSNP
rs1265015599 88 dbSNP
rs980872402 92 dbSNP
rs1243882740 97 dbSNP
rs565218135 100 dbSNP
rs1270182362 102 dbSNP
rs891380816 107 dbSNP
rs1008452796 119 dbSNP
rs532301055 121 dbSNP
rs762712457 124 dbSNP
rs892155657 125 dbSNP
rs547621808 128 dbSNP
rs112335543 132 dbSNP
rs960647436 133 dbSNP
rs1009226315 136 dbSNP
rs1022089924 139 dbSNP
rs988027902 140 dbSNP
rs1303624073 141 dbSNP
rs565753263 145 dbSNP
rs946571665 146 dbSNP
rs960919404 149 dbSNP
rs1424598673 151 dbSNP
rs371016635 153 dbSNP
rs536419235 156 dbSNP
rs926059753 157 dbSNP
rs1430628163 166 dbSNP
rs549093626 176 dbSNP
rs992063210 177 dbSNP
rs1487552173 178 dbSNP
rs1244183602 186 dbSNP
rs774381798 189 dbSNP
rs1182070579 193 dbSNP
rs961387385 207 dbSNP
rs974036828 208 dbSNP
rs537209546 209 dbSNP
rs901165063 213 dbSNP
rs998152113 224 dbSNP
rs932698157 236 dbSNP
rs1442167965 238 dbSNP
rs1431144679 241 dbSNP
rs986046321 241 dbSNP
rs1358826691 243 dbSNP
rs1332371683 245 dbSNP
rs912708130 246 dbSNP
rs1406919913 249 dbSNP
rs1169950682 251 dbSNP
rs1170673105 252 dbSNP
rs567408864 256 dbSNP
rs759780728 257 dbSNP
rs1187508298 263 dbSNP
rs1168284279 267 dbSNP
rs187618216 272 dbSNP
rs892046401 280 dbSNP
rs1006144854 294 dbSNP
rs1043374909 301 dbSNP
rs1197977396 311 dbSNP
rs1305726625 311 dbSNP
rs1297573386 319 dbSNP
rs1466421335 323 dbSNP
rs903611491 327 dbSNP
rs1303577935 331 dbSNP
rs1214955891 340 dbSNP
rs537891560 341 dbSNP
rs1357337951 345 dbSNP
rs1001930318 347 dbSNP
rs1282711009 348 dbSNP
rs1454771685 352 dbSNP
rs1017086648 366 dbSNP
rs10563429 366 dbSNP
rs1205132166 366 dbSNP
rs1210164471 366 dbSNP
rs1232544682 366 dbSNP
rs1289298389 366 dbSNP
rs1320955759 366 dbSNP
rs1479338874 366 dbSNP
rs548282430 366 dbSNP
rs61209712 366 dbSNP
rs751739602 366 dbSNP
rs879128327 366 dbSNP
rs1382332414 369 dbSNP
rs969585329 376 dbSNP
rs1001954894 391 dbSNP
rs1450478578 392 dbSNP
rs1034699957 393 dbSNP
rs1299955901 394 dbSNP
rs58259095 394 dbSNP
rs1491057106 395 dbSNP
rs960366122 395 dbSNP
rs987744463 403 dbSNP
rs1389745309 408 dbSNP
rs1375611605 412 dbSNP
rs1228286001 425 dbSNP
rs879047605 427 dbSNP
rs1271573561 428 dbSNP
rs1314303637 429 dbSNP
rs1013822478 435 dbSNP
rs1436360016 439 dbSNP
rs556138086 448 dbSNP
rs577570939 449 dbSNP
rs538971546 454 dbSNP
rs967925558 455 dbSNP
rs1026914722 469 dbSNP
rs554409423 471 dbSNP
rs1248068981 474 dbSNP
rs910383300 476 dbSNP
rs1252034015 480 dbSNP
rs572571057 483 dbSNP
rs1346043665 489 dbSNP
rs752815270 492 dbSNP
rs543180940 493 dbSNP
rs1285655639 504 dbSNP
rs560999783 505 dbSNP
rs944255260 506 dbSNP
rs1218679933 509 dbSNP
rs1344196289 513 dbSNP
rs1305430015 514 dbSNP
rs1405939544 518 dbSNP
rs1360284915 521 dbSNP
rs1451135447 531 dbSNP
rs576195081 532 dbSNP
rs1159221709 540 dbSNP
rs1432047951 541 dbSNP
rs1175124117 550 dbSNP
rs1427113239 561 dbSNP
rs1405572948 563 dbSNP
rs989383509 565 dbSNP
rs1262169261 568 dbSNP
rs557177582 571 dbSNP
rs1486985962 572 dbSNP
rs137925829 574 dbSNP
rs1209512282 575 dbSNP
rs887384830 579 dbSNP
rs1430184167 582 dbSNP
rs1268865748 588 dbSNP
rs764568183 597 dbSNP
rs1285815070 604 dbSNP
rs1038980172 612 dbSNP
rs1220128762 619 dbSNP
rs879173516 621 dbSNP
rs564875395 622 dbSNP
rs1210183014 623 dbSNP
rs1034752282 631 dbSNP
rs1463997707 635 dbSNP
rs960416764 636 dbSNP
rs1248341104 646 dbSNP
rs1009217030 648 dbSNP
rs1178552682 657 dbSNP
rs1020559656 660 dbSNP
rs532100453 665 dbSNP
rs1480711717 666 dbSNP
rs968409267 671 dbSNP
rs540990857 675 dbSNP
rs1430013176 676 dbSNP
rs759218127 676 dbSNP
rs1200077517 684 dbSNP
rs1460089077 684 dbSNP
rs1017904451 693 dbSNP
rs1265047726 696 dbSNP
rs1204913741 698 dbSNP
rs1317860591 701 dbSNP
rs964577778 713 dbSNP
rs1230073810 715 dbSNP
rs1426916551 716 dbSNP
rs1327329455 717 dbSNP
rs192479576 730 dbSNP
rs1451426716 732 dbSNP
rs1380006317 734 dbSNP
rs529882436 737 dbSNP
rs897085810 740 dbSNP
rs114241507 741 dbSNP
rs1463385996 742 dbSNP
rs1412979148 748 dbSNP
rs751123059 751 dbSNP
rs1442984210 754 dbSNP
rs954101344 764 dbSNP
rs567469764 768 dbSNP
rs1457319429 769 dbSNP
rs1249045641 770 dbSNP
rs1400131102 785 dbSNP
rs985857863 786 dbSNP
rs1420351007 804 dbSNP
rs908539030 805 dbSNP
rs531696689 806 dbSNP
rs1356869455 807 dbSNP
rs565775352 807 dbSNP
rs1452747072 809 dbSNP
rs1437765812 810 dbSNP
rs1334647800 820 dbSNP
rs1019736608 823 dbSNP
rs879170439 827 dbSNP
rs377615012 829 dbSNP
rs965806225 830 dbSNP
rs941326612 832 dbSNP
rs536347136 833 dbSNP
rs1422469527 838 dbSNP
rs905421108 840 dbSNP
rs12177 841 dbSNP
rs573116574 844 dbSNP
rs1438925896 846 dbSNP
rs571639310 846 dbSNP
rs1349537854 849 dbSNP
rs896264250 850 dbSNP
rs1221539398 851 dbSNP
rs1009269304 852 dbSNP
rs1293567441 853 dbSNP
rs937725443 853 dbSNP
rs1349382409 854 dbSNP
rs1055195224 855 dbSNP
rs769838704 858 dbSNP
rs1240501699 863 dbSNP
rs1020611989 866 dbSNP
rs1291364239 870 dbSNP
rs777636115 871 dbSNP
rs1000898499 875 dbSNP
rs1220726910 877 dbSNP
rs1036845165 879 dbSNP
rs1017539214 893 dbSNP
rs1266770355 894 dbSNP
rs1160404359 896 dbSNP
rs964955514 903 dbSNP
rs1429218933 906 dbSNP
rs975940050 913 dbSNP
rs1252749604 918 dbSNP
rs1048334429 920 dbSNP
rs1469845644 934 dbSNP
rs1270010475 943 dbSNP
rs749264064 946 dbSNP
rs1416021498 947 dbSNP
rs955478135 951 dbSNP
rs1206381902 954 dbSNP
rs571564826 958 dbSNP
rs1221603799 965 dbSNP
rs1347225333 966 dbSNP
rs1458120927 971 dbSNP
rs1343660306 972 dbSNP
rs1320471147 987 dbSNP
rs1020001825 988 dbSNP
rs183268897 994 dbSNP
rs1309056218 997 dbSNP
rs1174957631 1004 dbSNP
rs1335591086 1013 dbSNP
rs771948792 1021 dbSNP
rs1439544176 1026 dbSNP
rs545704098 1030 dbSNP
rs1020360454 1032 dbSNP
rs941390842 1038 dbSNP
rs1240014927 1041 dbSNP
rs1194855789 1046 dbSNP
rs974453098 1056 dbSNP
rs968902289 1057 dbSNP
rs77746386 1059 dbSNP
rs978915421 1061 dbSNP
rs926924647 1063 dbSNP
rs143495046 1064 dbSNP
rs1344255502 1070 dbSNP
rs2240193 1077 dbSNP
rs575514572 1081 dbSNP
rs536888086 1082 dbSNP
rs555197845 1084 dbSNP
rs1249515997 1086 dbSNP
rs576661990 1092 dbSNP
rs945513556 1093 dbSNP
rs1036770223 1094 dbSNP
rs1045670 1097 dbSNP
rs147167660 1098 dbSNP
rs1000548340 1100 dbSNP
rs764951806 1102 dbSNP
rs2240192 1103 dbSNP
rs1449727367 1107 dbSNP
rs997428814 1118 dbSNP
rs1007192877 1119 dbSNP
rs1408639277 1123 dbSNP
rs1030221700 1126 dbSNP
rs950536329 1127 dbSNP
rs1181222973 1128 dbSNP
rs1335708811 1131 dbSNP
rs1004696743 1135 dbSNP
rs1041067807 1138 dbSNP
rs879369423 1142 dbSNP
rs1203732117 1143 dbSNP
rs2240191 1147 dbSNP
rs963106516 1148 dbSNP
rs1228806373 1149 dbSNP
rs1010226801 1157 dbSNP
rs559431579 1163 dbSNP
rs1454660514 1166 dbSNP
rs1020412892 1167 dbSNP
rs1229020488 1176 dbSNP
rs189151018 1177 dbSNP
rs1000367055 1180 dbSNP
rs754238343 1181 dbSNP
rs974125615 1185 dbSNP
rs530001002 1194 dbSNP
rs762403389 1197 dbSNP
rs1424351078 1200 dbSNP
rs959649851 1207 dbSNP
rs139337751 1213 dbSNP
rs918129399 1214 dbSNP
rs1461963907 1217 dbSNP
rs1203324780 1220 dbSNP
rs945566030 1221 dbSNP
rs1176600324 1222 dbSNP
rs1479630861 1222 dbSNP
rs1451471756 1223 dbSNP
rs1205613214 1226 dbSNP
rs1024546865 1227 dbSNP
rs1490108234 1233 dbSNP
rs1289937131 1234 dbSNP
rs1248437916 1235 dbSNP
rs1322444017 1236 dbSNP
rs970401778 1237 dbSNP
rs918340351 1239 dbSNP
rs972370245 1239 dbSNP
rs1309110026 1245 dbSNP
rs765478417 1246 dbSNP
rs750857446 1247 dbSNP
rs931031736 1252 dbSNP
rs1300952691 1261 dbSNP
rs1373017403 1265 dbSNP
rs1474596985 1274 dbSNP
rs964657956 1279 dbSNP
rs911025017 1280 dbSNP
rs1416724448 1283 dbSNP
rs1410083191 1284 dbSNP
rs754651344 1289 dbSNP
rs936398457 1293 dbSNP
rs942528966 1297 dbSNP
rs1266465770 1305 dbSNP
rs1038733763 1307 dbSNP
rs767333563 1313 dbSNP
rs1334339658 1319 dbSNP
rs997147072 1320 dbSNP
rs946067520 1328 dbSNP
rs1051702288 1348 dbSNP
rs1223402828 1351 dbSNP
rs1344078573 1356 dbSNP
rs886328594 1357 dbSNP
rs1285610631 1365 dbSNP
rs1390186686 1366 dbSNP
rs563154031 1368 dbSNP
rs1041699479 1369 dbSNP
rs904614778 1375 dbSNP
rs1287866917 1379 dbSNP
rs1000252155 1380 dbSNP
rs1004749169 1385 dbSNP
rs1016494212 1386 dbSNP
rs57853289 1387 dbSNP
rs1427051310 1390 dbSNP
rs1201326839 1392 dbSNP
rs1235094736 1394 dbSNP
rs995989866 1396 dbSNP
rs1261374053 1399 dbSNP
rs1025018257 1403 dbSNP
rs1268829104 1408 dbSNP
rs1275189872 1409 dbSNP
rs1322073858 1409 dbSNP
rs752247879 1410 dbSNP
rs755523406 1413 dbSNP
rs549882416 1414 dbSNP
rs368697368 1424 dbSNP
rs1234435538 1427 dbSNP
rs777367696 1432 dbSNP
rs1326196618 1433 dbSNP
rs567740447 1433 dbSNP
rs746749529 1433 dbSNP
rs918181689 1441 dbSNP
rs532432724 1447 dbSNP
rs117834443 1458 dbSNP
rs1320665406 1460 dbSNP
rs1451222276 1463 dbSNP
rs984298775 1464 dbSNP
rs910958904 1465 dbSNP
rs1466422374 1466 dbSNP
rs978306149 1467 dbSNP
rs925437920 1470 dbSNP
rs942560628 1472 dbSNP
rs144362326 1476 dbSNP
rs1248840284 1478 dbSNP
rs867708689 1479 dbSNP
rs922515019 1485 dbSNP
rs536948403 1488 dbSNP
rs1245570553 1492 dbSNP
rs1201692870 1494 dbSNP
rs1339179099 1505 dbSNP
rs945911977 1507 dbSNP
rs1230007508 1508 dbSNP
rs1343893513 1518 dbSNP
rs1297805415 1521 dbSNP
rs1041753193 1525 dbSNP
rs921659324 1530 dbSNP
rs148791271 1533 dbSNP
rs932987580 1534 dbSNP
rs1396515895 1544 dbSNP
rs367763801 1545 dbSNP
rs935974106 1546 dbSNP
rs114014432 1549 dbSNP
rs1004801449 1550 dbSNP
rs1413717972 1555 dbSNP
rs1391030594 1556 dbSNP
rs558403931 1565 dbSNP
rs1037573909 1569 dbSNP
rs899002134 1575 dbSNP
rs1001335939 1583 dbSNP
rs1287817294 1584 dbSNP
rs1188906242 1585 dbSNP
rs1034197935 1594 dbSNP
rs1248982373 1602 dbSNP
rs1197928505 1606 dbSNP
rs895205196 1615 dbSNP
rs1274993088 1616 dbSNP
rs1388423708 1623 dbSNP
rs1013567994 1629 dbSNP
rs1244756440 1633 dbSNP
rs1356709850 1642 dbSNP
rs1285473391 1644 dbSNP
rs1244832335 1653 dbSNP
rs576862409 1656 dbSNP
rs760759216 1658 dbSNP
rs1344637674 1668 dbSNP
rs1024912187 1670 dbSNP
rs12309946 1671 dbSNP
rs1302819664 1671 dbSNP
rs978739564 1672 dbSNP
rs745722111 1678 dbSNP
rs1331510034 1680 dbSNP
rs1469628414 1688 dbSNP
rs1362629027 1689 dbSNP
rs756814490 1692 dbSNP
rs1239808320 1698 dbSNP
rs1260184841 1700 dbSNP
rs958468369 1701 dbSNP
rs552938891 1705 dbSNP
rs1220658533 1710 dbSNP
rs1212140020 1712 dbSNP
rs1489738208 1714 dbSNP
rs921710134 1731 dbSNP
rs993689981 1732 dbSNP
rs1209929390 1734 dbSNP
rs1349312947 1736 dbSNP
rs1270320235 1739 dbSNP
rs574314178 1747 dbSNP
rs192163255 1748 dbSNP
rs1350934984 1751 dbSNP
rs1253479465 1753 dbSNP
rs1402823819 1759 dbSNP
rs1419273636 1776 dbSNP
rs1324378369 1777 dbSNP
rs34413992 1780 dbSNP
rs1005208387 1781 dbSNP
rs1157984491 1787 dbSNP
rs1382845048 1790 dbSNP
rs1018478030 1791 dbSNP
rs963789313 1798 dbSNP
rs1429153754 1802 dbSNP
rs1197721550 1807 dbSNP
rs1479177713 1812 dbSNP
rs1361546316 1813 dbSNP
rs143934619 1828 dbSNP
rs1164061767 1831 dbSNP
rs922400463 1836 dbSNP
rs1364902507 1838 dbSNP
rs1265671696 1844 dbSNP
rs1210003718 1846 dbSNP
rs1402822268 1850 dbSNP
rs940335303 1851 dbSNP
rs1038025511 1853 dbSNP
rs899058189 1854 dbSNP
rs1392154261 1856 dbSNP
rs528047599 1868 dbSNP
rs1306626141 1870 dbSNP
rs1315195373 1871 dbSNP
rs1275709493 1878 dbSNP
rs772278845 1879 dbSNP
rs1197855027 1882 dbSNP
rs77461326 1885 dbSNP
rs1324865057 1887 dbSNP
rs1322680573 1888 dbSNP
rs1435821501 1898 dbSNP
rs937182844 1900 dbSNP
rs775624930 1901 dbSNP
rs184637293 1902 dbSNP
rs1013620169 1908 dbSNP
rs1416581030 1916 dbSNP
rs1024963086 1918 dbSNP
rs545576121 1925 dbSNP
rs565273769 1926 dbSNP
rs1245771842 1947 dbSNP
rs768567759 1954 dbSNP
rs1189943130 1955 dbSNP
rs1464907815 1970 dbSNP
rs1055760699 1974 dbSNP
rs532636125 1975 dbSNP
rs189546414 1976 dbSNP
rs1443978261 1977 dbSNP
rs958303010 1982 dbSNP
rs547527547 1983 dbSNP
rs191787084 1984 dbSNP
rs573361310 1986 dbSNP
rs993610685 1986 dbSNP
rs1049333199 1992 dbSNP
rs1183695722 1995 dbSNP
rs375441676 2001 dbSNP
rs1384493273 2005 dbSNP
rs1422629223 2007 dbSNP
rs987227784 2016 dbSNP
rs1328638936 2018 dbSNP
rs548927637 2021 dbSNP
rs781513950 2022 dbSNP
rs1461353709 2024 dbSNP
rs866377325 2027 dbSNP
rs570349854 2028 dbSNP
rs537682356 2029 dbSNP
rs964147181 2034 dbSNP
rs1237917579 2044 dbSNP
rs1203577496 2046 dbSNP
rs1481943495 2047 dbSNP
rs1277123199 2051 dbSNP
rs1315785562 2052 dbSNP
rs920535683 2053 dbSNP
rs1358877798 2058 dbSNP
rs1244408391 2062 dbSNP
rs773694544 2073 dbSNP
rs1230062771 2076 dbSNP
rs368799616 2079 dbSNP
rs1308385414 2090 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 22895.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202477. RNA binding protein: AGO2. Condition:S2_LV_25yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202478. RNA binding protein: AGO2. Condition:S3_LV_36yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000415485.3 | 3UTR | CACACAUGUACACACACACAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000415485.3 | 3UTR | AUGUACACACACACACACACAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000415485.3 | 3UTR | ACAUGUACACACACACACACACAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4666a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057266 FAM35A family with sequence similarity 35 member A 2 2
MIRT059969 PATL1 PAT1 homolog 1, processing body mRNA decay factor 2 6
MIRT079031 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT079631 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT086974 LANCL1 LanC like 1 2 2
MIRT091804 GOLGA4 golgin A4 2 2
MIRT229501 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT255972 WDR17 WD repeat domain 17 2 2
MIRT262975 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT264774 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT334169 CCND1 cyclin D1 2 6
MIRT345868 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT452477 DDX4 DEAD-box helicase 4 2 2
MIRT455764 TSPAN6 tetraspanin 6 2 4
MIRT461627 DCAF15 DDB1 and CUL4 associated factor 15 2 4
MIRT465169 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT468950 RPS14 ribosomal protein S14 2 6
MIRT483236 C2orf72 chromosome 2 open reading frame 72 2 8
MIRT498544 TMEM30B transmembrane protein 30B 2 2
MIRT500633 TXNIP thioredoxin interacting protein 2 4
MIRT504113 GPR158 G protein-coupled receptor 158 2 2
MIRT504428 ZNF85 zinc finger protein 85 2 6
MIRT505036 ZNF451 zinc finger protein 451 2 2
MIRT506526 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT508773 GSG1 germ cell associated 1 2 2
MIRT517297 ELF4 E74 like ETS transcription factor 4 2 6
MIRT519353 OBFC1 STN1, CST complex subunit 2 4
MIRT523891 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT527509 ZNF134 zinc finger protein 134 2 2
MIRT531218 IFNGR2 interferon gamma receptor 2 2 2
MIRT535957 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT537229 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 4
MIRT537337 FKBP5 FK506 binding protein 5 2 2
MIRT539125 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT539910 ISPD isoprenoid synthase domain containing 2 2
MIRT541527 MGAT4C MGAT4 family member C 2 2
MIRT546119 USP25 ubiquitin specific peptidase 25 2 2
MIRT548846 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT549892 LINC00955 long intergenic non-protein coding RNA 955 2 2
MIRT549898 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550763 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT553200 UBE2A ubiquitin conjugating enzyme E2 A 2 2
MIRT553970 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT554092 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT555208 PROX1 prospero homeobox 1 2 4
MIRT555834 PAX5 paired box 5 2 4
MIRT556865 JAZF1 JAZF zinc finger 1 2 2
MIRT558594 CREBL2 cAMP responsive element binding protein like 2 2 2
MIRT559690 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT563312 ORC4 origin recognition complex subunit 4 2 2
MIRT563585 FAM229B family with sequence similarity 229 member B 2 2
MIRT563853 ALYREF Aly/REF export factor 2 4
MIRT565146 TUBB2A tubulin beta 2A class IIa 2 2
MIRT565769 SEPHS1 selenophosphate synthetase 1 2 2
MIRT568317 BACH1 BTB domain and CNC homolog 1 2 2
MIRT575387 Unc5b unc-5 netrin receptor B 2 4
MIRT607728 BDH1 3-hydroxybutyrate dehydrogenase 1 2 8
MIRT612691 PLXNA4 plexin A4 2 4
MIRT615916 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT629792 P2RY1 purinergic receptor P2Y1 2 2
MIRT632119 FKBP9 FK506 binding protein 9 2 2
MIRT645554 ZDHHC15 zinc finger DHHC-type containing 15 2 4
MIRT651479 WWC3 WWC family member 3 2 2
MIRT654138 RPH3A rabphilin 3A 2 6
MIRT655191 PHAX phosphorylated adaptor for RNA export 2 2
MIRT665543 UNC5B unc-5 netrin receptor B 2 5
MIRT668057 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT678978 CERS4 ceramide synthase 4 2 4
MIRT679124 RBM3 RNA binding motif (RNP1, RRM) protein 3 2 2
MIRT686776 AZF1 azoospermia factor 1 2 2
MIRT687144 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT691453 C21orf58 chromosome 21 open reading frame 58 2 2
MIRT691469 FAM98B family with sequence similarity 98 member B 2 2
MIRT697031 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT698401 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT702056 RNMT RNA guanine-7 methyltransferase 2 2
MIRT705903 ADAM9 ADAM metallopeptidase domain 9 2 2
MIRT707491 MMADHC methylmalonic aciduria and homocystinuria, cblD type 2 2
MIRT708080 KLHL23 kelch like family member 23 2 2
MIRT709738 TRIM27 tripartite motif containing 27 2 2
MIRT710056 RWDD2A RWD domain containing 2A 2 2
MIRT710226 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT712043 STYK1 serine/threonine/tyrosine kinase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4666a Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)

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