miRTarBase - #MIRT655997


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pre-miRNA Information
pre-miRNA hsa-mir-378f   
Genomic Coordinates chr1: 23929070 - 23929147
Description Homo sapiens miR-378f stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378f
Sequence 52| ACUGGACUUGGAGCCAGAAG |71
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 18 1 + 23929138 29233923 MiREDiBase
A-to-I 19 1 + 23929139 29233923 MiREDiBase
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MYRF   
Synonyms C11orf9, MRF, Ndt80, pqn-47
Description myelin regulatory factor
Transcript NM_001127392   
Other Transcripts NM_013279   
Expression
Putative miRNA Targets on MYRF
3'UTR of MYRF
(miRNA target sites are highlighted)		 
>MYRF|NM_001127392|3'UTR
   1 GCTGCCCTCCTGAGGCAGCACCACACCAGGGACCAGGGGTGCCCAGGCACCCCCCAACACTGGATGCAATGGTGTTACAC
  81 TGGAGCCCGCTGCAGGCCAGCTCTGCTGTTCACTGGCCCTACCCGAGACTGGTGAAACTGGAAGTCTTCACACTGGAGTT
 161 GCTGTTCCAGCTGGTCGCCCCTCACGGCACAGAGGGAACCTGAGAGCCAGAGACTTCTTGGGCCTTCCTGCCTGCCACCC
 241 CCTAGGGGCCAGGACAGGACCAGTTTACCTCTTTCCAGATATGGTGGTTGGAGGGCTGGTTCAGGTGCCCTGGAGGGAAG
 321 GGGAAGCCTGTGGCCCTGATTTGTTCAGAGCCCATTCTCCCTTGCCTCCCCTTTTGAGACTGGAGCCAACCCTTTTGGAG
 401 AGAGGACCTGCCCACCTTTGAGATCAGCAGGGGGCTCGGATCCAGCCCTAAGAGACTTGGGTGGACCCCCATGAGTCAAT
 481 GGAGGGCAGACGGCTCTCCCCCTTAAAGCTGTTCCCTGGGGGATGGCTTGGTAGTGGACTTTCTGGGGTTTGCCTGTTAC
 561 GCCAGACTCGGACTTCTAAGCTTTAAGTGTGGCCCAGGAGGTTTCTTCTCCCTGGGAGGGCTTGGCTCCCAAGAAGTCCC
 641 AGGGCAGCCGAGGCCAGCCCTGCCTGGGTTGGAGAAACTGACTTTGTGCCTTAAGTCTACTCAGTGCCTGGTGAAGCCAC
 721 CCTCAGCCCTTCACAGGCCTGAACCAGTAGGGGCCAGTGGGCCAGGTAAGCCCTAGAGCCTTGAACCAGGAATATCCAGG
 801 AAGAGGAAATTCCCTTTGAGCCCCCAGATGGTATTGCAGCTTCACTGCCTGCGTTCCTGGGAGCGTCTGGAGCTCACAGT
 881 GATCAGTGACCACATCATTCTCTCTGAGCAGAGGAGCAGGAATCCCTCAAGCAGCAGCCTGGTCTTGGCTGGTGGGCAGA
 961 TGCAAATAGCTTTTGCTGTTATTAATGAAGTAATTACTAAATGCACTTAAACCAGGGCAGGAAGGAATGGAAGGATGGAG
1041 CTAGAAAGCTCAGAGTGGGCCAGAGCAGGGGTGTGACACTTGCAAAGACAGGGCTCTGACTCTGATCCCTCCCAGGGAGC
1121 CTCCGACACCCATCCCACTCCCAACCACCAAGACCCTGGGTTAGGGAAGAAGTTGTATCTTAAGTGCCACCTTCAAGTTT
1201 CTTAGTGGTGCCTGGTGCATTCCGAGGCTACATCCAGGCTCATGGAAGGAGTGTAGTATTCATTTAGCCATGTCTGCCAT
1281 GGGTCCAGAAATGGGAAAGGGAATTGCTGTCCTTGCCCTGTGGTATGCTGCCACCTCTTTGGGAAGCAGGCCTTGCCCCT
1361 GTCCCACCACTCATTCTCAGCTTTGAATGGGAGGCCTTTCTATAGTGGAGGCCTTTCCTTGAAGCCTATGAACTGCAGGC
1441 CCCCTTTTGCCATTGATCTCAAAGCACTTGTCCTCAGGATAGGGAAGAGCAGGGGGATGCAGGAATAGCAGGGATAGCTT
1521 GCTCCCAGCCCCCTCCCCAATTTGGTTCCGTTGACATAGGAATTTTACGATTCCCAAACCATGCAGGGGCTGAGCCTTCC
1601 TTATGATGACTTTGTTCTCCCTCCCACTGGGGGAATCCTCCCTATGCCTTAAAACTGCCGAGCCCCACTCCATGTAATAG
1681 GATTCCTGGGCTTCCTCAATGGGGGTTCATGTTCTTGGACTGCGGGCCCTCAGTCCTTAACTGGAAAGTGACCGTCCACT
1761 GCCCCATGGAGCCCATCTGGACACAGCACAGCCCCAAAACCGTTAGCAGCTGGCTCTGTTTCCAAGCCTGGGGAGGGGTT
1841 CCTCAGTGCAGGAGTTGGGGACAGGCTGGGGATCCAAGCTGCTTGAGGGGGTCAACCTTGGACCAAAGTTGCCTTAAGCC
1921 TGTGGTAAAAGGGCTTCAGGGAAGGTAAGTGGGCCACCTGCTGGAAGCTGCCAGCTGCCCGGCTGGCAATGGTGTGAGTG
2001 TCTTGGCCCTGTCCCTGCCCTGGGGTCCAGCAGGTCATCCCTCCCTTCTTCTCTCTCCTTTGGCGTTTGTTCCTGTAGTC
2081 ACTGGGCTAATCTCCCCCTAGCTTCAAGCTGTACATAGGGCCTCCCAGTGCAAATCCTCCTGCCCATACCGTGCACCCTT
2161 AGAAGCCTGCGTGTGCATAGAGCGCCCCCTACTTCCCAGTTAACTCCCAGTTCTTCTCCCTGAGCTTGGTATTTGTCATG
2241 TGCCAACTCTGACTCTGAGGTGGGCAGTGAGGGAAGCAGCCCCGGGCCTGCTTGCTTCCTGTCCCCGAAATGTTCGTTTC
2321 TTCTGAAGTAAATATACATATATAAATAAATGTATAAATACTGCTTTGTATCTGAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaagACCGA-GGU--UCAGGUCa 5'
              || || |||  :|||||| 
Target 5' gccaTGTCTGCCATGGGTCCAGa 3'
 1267 - 1289 138.00 -15.30
2 
miRNA  3' gaaGACCGAGGUUCAGGUCa 5'
             ||| | : ::|||||| 
Target 5' tccCTGCCCTGGGGTCCAGc 3'
 2012 - 2031 137.00 -13.70
3 
miRNA  3' gaaGACCGAGG----UUCA-GGUCa 5'
             :|||||||    |||| |||| 
Target 5' ggcTTGGCTCCCAAGAAGTCCCAGg 3'
 619 - 643 135.00 -19.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30466652 25 COSMIC
COSN31504595 35 COSMIC
COSN31523244 44 COSMIC
COSN18721383 50 COSMIC
COSN1135638 215 COSMIC
COSN23987317 247 COSMIC
COSN23516776 308 COSMIC
COSN24229792 447 COSMIC
COSN31532120 524 COSMIC
COSN31485766 606 COSMIC
COSN31545624 1379 COSMIC
COSN31521949 1559 COSMIC
COSN31541263 1569 COSMIC
COSN30109725 1788 COSMIC
COSN26664668 1869 COSMIC
COSN31480739 1905 COSMIC
COSN5307980 1949 COSMIC
COSN31524431 2007 COSMIC
COSN29460203 2031 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1362590784 6 dbSNP
rs1456991779 10 dbSNP
rs770303577 15 dbSNP
rs1390464147 22 dbSNP
rs780449106 23 dbSNP
rs370300145 25 dbSNP
rs1232440955 26 dbSNP
rs373840168 27 dbSNP
rs771488548 28 dbSNP
rs918573321 31 dbSNP
rs1022979622 32 dbSNP
rs1315476082 34 dbSNP
rs1254242465 35 dbSNP
rs772943863 35 dbSNP
rs1201370695 40 dbSNP
rs760393204 41 dbSNP
rs770025510 42 dbSNP
rs377756 47 dbSNP
rs1271335509 49 dbSNP
rs770777952 50 dbSNP
rs775491121 50 dbSNP
rs1466471063 51 dbSNP
rs1450860404 73 dbSNP
rs1167987441 82 dbSNP
rs767776804 89 dbSNP
rs773279834 90 dbSNP
rs1240845735 93 dbSNP
rs1335728562 94 dbSNP
rs1311638360 106 dbSNP
rs376889849 125 dbSNP
rs766607632 126 dbSNP
rs1453794398 141 dbSNP
rs137932499 145 dbSNP
rs114764590 152 dbSNP
rs912143186 154 dbSNP
rs943649942 156 dbSNP
rs1229788259 162 dbSNP
rs1270846290 168 dbSNP
rs1158475625 177 dbSNP
rs751221876 178 dbSNP
rs1045199944 179 dbSNP
rs1181221698 184 dbSNP
rs1443575133 186 dbSNP
rs975012160 186 dbSNP
rs920949377 187 dbSNP
rs947111822 189 dbSNP
rs661246 190 dbSNP
rs113036587 194 dbSNP
rs661248 195 dbSNP
rs1217238367 201 dbSNP
rs902965142 203 dbSNP
rs866948122 205 dbSNP
rs571969753 207 dbSNP
rs541224623 215 dbSNP
rs1010133265 218 dbSNP
rs1021495567 223 dbSNP
rs895699128 226 dbSNP
rs755413655 229 dbSNP
rs1202786809 239 dbSNP
rs1298046161 240 dbSNP
rs1420774205 241 dbSNP
rs1013251641 242 dbSNP
rs1044394673 245 dbSNP
rs899177888 247 dbSNP
rs554457488 253 dbSNP
rs1241277275 257 dbSNP
rs1448666723 272 dbSNP
rs985268774 275 dbSNP
rs368658 279 dbSNP
rs193274536 280 dbSNP
rs1474258243 281 dbSNP
rs371066294 283 dbSNP
rs950901859 289 dbSNP
rs1009058099 295 dbSNP
rs1266720522 309 dbSNP
rs368608 316 dbSNP
rs765747259 323 dbSNP
rs976836069 339 dbSNP
rs1230235567 344 dbSNP
rs368576 349 dbSNP
rs368574 351 dbSNP
rs753261258 352 dbSNP
rs1277900636 355 dbSNP
rs1401018328 362 dbSNP
rs1171241045 364 dbSNP
rs964968845 365 dbSNP
rs1301807891 367 dbSNP
rs184526863 371 dbSNP
rs1404276465 372 dbSNP
rs915524907 377 dbSNP
rs1384432099 383 dbSNP
rs1166294910 393 dbSNP
rs968337119 397 dbSNP
rs1319499615 398 dbSNP
rs1422499033 401 dbSNP
rs978437893 408 dbSNP
rs1171072961 409 dbSNP
rs539798109 411 dbSNP
rs1427002382 426 dbSNP
rs1488805115 429 dbSNP
rs984404003 429 dbSNP
rs910141597 430 dbSNP
rs948246362 438 dbSNP
rs924378173 439 dbSNP
rs1219526258 450 dbSNP
rs1428700622 455 dbSNP
rs1320425726 459 dbSNP
rs1281845073 460 dbSNP
rs1219083191 466 dbSNP
rs934415225 466 dbSNP
rs1285498845 470 dbSNP
rs1439431422 473 dbSNP
rs528923289 476 dbSNP
rs532564151 480 dbSNP
rs906672755 485 dbSNP
rs1403630320 492 dbSNP
rs1175949953 493 dbSNP
rs75481484 503 dbSNP
rs1175097075 508 dbSNP
rs757872280 512 dbSNP
rs1427210420 518 dbSNP
rs1192955297 531 dbSNP
rs938458220 537 dbSNP
rs1237703952 543 dbSNP
rs73487455 548 dbSNP
rs777391959 554 dbSNP
rs1209881827 558 dbSNP
rs556427612 561 dbSNP
rs1222612381 562 dbSNP
rs994833415 571 dbSNP
rs1205679493 585 dbSNP
rs1260917531 588 dbSNP
rs1006786651 592 dbSNP
rs1301996250 602 dbSNP
rs1047792374 607 dbSNP
rs886489924 613 dbSNP
rs1009416880 615 dbSNP
rs1019085669 617 dbSNP
rs879352802 625 dbSNP
rs1419088370 638 dbSNP
rs150504612 646 dbSNP
rs1179349258 648 dbSNP
rs1441723558 650 dbSNP
rs780780510 651 dbSNP
rs745666793 653 dbSNP
rs1483769522 669 dbSNP
rs1258197506 683 dbSNP
rs769767308 688 dbSNP
rs1214269533 691 dbSNP
rs978364585 695 dbSNP
rs924275390 713 dbSNP
rs1196758167 717 dbSNP
rs1286035480 717 dbSNP
rs1427664586 720 dbSNP
rs547468837 723 dbSNP
rs139640407 726 dbSNP
rs1311534127 732 dbSNP
rs917033790 733 dbSNP
rs948514834 735 dbSNP
rs1044288905 738 dbSNP
rs1399102328 740 dbSNP
rs1305042269 742 dbSNP
rs1361111858 757 dbSNP
rs1159285880 761 dbSNP
rs1421554771 764 dbSNP
rs562128591 767 dbSNP
rs984122386 774 dbSNP
rs1346168195 789 dbSNP
rs1404593482 792 dbSNP
rs909860532 794 dbSNP
rs1424683894 801 dbSNP
rs768014488 808 dbSNP
rs928145742 809 dbSNP
rs1337353588 814 dbSNP
rs149315061 818 dbSNP
rs1260130428 823 dbSNP
rs1047702443 825 dbSNP
rs1353622570 835 dbSNP
rs1348450303 840 dbSNP
rs886453312 846 dbSNP
rs1057318608 849 dbSNP
rs542054340 853 dbSNP
rs1040842659 854 dbSNP
rs1196873152 857 dbSNP
rs945761069 865 dbSNP
rs549633165 866 dbSNP
rs775561068 877 dbSNP
rs1182981249 887 dbSNP
rs1388661173 889 dbSNP
rs1293019607 891 dbSNP
rs996292753 897 dbSNP
rs1458551866 913 dbSNP
rs1370441860 929 dbSNP
rs1168933066 936 dbSNP
rs1022428457 949 dbSNP
rs904074657 953 dbSNP
rs999750493 957 dbSNP
rs1031305184 968 dbSNP
rs555552791 974 dbSNP
rs1209931906 979 dbSNP
rs1489232894 983 dbSNP
rs1255723892 987 dbSNP
rs1438399473 993 dbSNP
rs569378840 995 dbSNP
rs955884762 999 dbSNP
rs1279931687 1001 dbSNP
rs1221539111 1004 dbSNP
rs901033280 1014 dbSNP
rs992530402 1018 dbSNP
rs1024470221 1019 dbSNP
rs998035802 1034 dbSNP
rs1025441971 1039 dbSNP
rs969827613 1041 dbSNP
rs1465357258 1049 dbSNP
rs951460429 1054 dbSNP
rs1424065367 1061 dbSNP
rs1005609272 1066 dbSNP
rs1458887111 1072 dbSNP
rs1398889545 1077 dbSNP
rs979895877 1078 dbSNP
rs1391822363 1093 dbSNP
rs1434372700 1095 dbSNP
rs1306029103 1104 dbSNP
rs1306585540 1105 dbSNP
rs920426506 1125 dbSNP
rs1259686189 1126 dbSNP
rs1333704037 1129 dbSNP
rs1198539871 1137 dbSNP
rs930520039 1139 dbSNP
rs1315593433 1140 dbSNP
rs1256486021 1146 dbSNP
rs1235392126 1150 dbSNP
rs538257189 1157 dbSNP
rs1373274870 1173 dbSNP
rs1307260880 1174 dbSNP
rs1219607588 1180 dbSNP
rs1377950175 1187 dbSNP
rs1333736193 1189 dbSNP
rs186683923 1197 dbSNP
rs983761983 1212 dbSNP
rs1480759320 1214 dbSNP
rs1173655185 1220 dbSNP
rs907812229 1224 dbSNP
rs944704434 1225 dbSNP
rs144553663 1227 dbSNP
rs981470681 1230 dbSNP
rs1456688263 1236 dbSNP
rs1439873784 1238 dbSNP
rs1239655005 1242 dbSNP
rs1185015473 1244 dbSNP
rs928230415 1255 dbSNP
rs139618041 1256 dbSNP
rs1202107141 1266 dbSNP
rs1351431501 1267 dbSNP
rs1444146146 1268 dbSNP
rs932072140 1270 dbSNP
rs879888462 1274 dbSNP
rs1162765478 1307 dbSNP
rs1043851743 1308 dbSNP
rs904042895 1310 dbSNP
rs1462699197 1312 dbSNP
rs1281465153 1335 dbSNP
rs1446161422 1340 dbSNP
rs370450409 1352 dbSNP
rs1340241785 1357 dbSNP
rs771306539 1360 dbSNP
rs1297768499 1390 dbSNP
rs1335278912 1395 dbSNP
rs879295672 1406 dbSNP
rs999727019 1409 dbSNP
rs914050458 1420 dbSNP
rs1031652474 1454 dbSNP
rs1042777069 1460 dbSNP
rs896771746 1480 dbSNP
rs1381679650 1487 dbSNP
rs1381945758 1492 dbSNP
rs374288 1493 dbSNP
rs1014326929 1510 dbSNP
rs1161083637 1517 dbSNP
rs755155914 1518 dbSNP
rs942370865 1534 dbSNP
rs1023980241 1541 dbSNP
rs534598383 1550 dbSNP
rs979863083 1551 dbSNP
rs1237830345 1552 dbSNP
rs1307516052 1558 dbSNP
rs114011375 1560 dbSNP
rs951843880 1569 dbSNP
rs901091571 1570 dbSNP
rs1217280876 1576 dbSNP
rs1488626556 1583 dbSNP
rs1286439053 1585 dbSNP
rs1205952050 1590 dbSNP
rs1244364983 1595 dbSNP
rs1461267556 1596 dbSNP
rs1285133384 1604 dbSNP
rs1235575116 1607 dbSNP
rs374112596 1615 dbSNP
rs1298071699 1624 dbSNP
rs34367178 1629 dbSNP
rs1401156867 1636 dbSNP
rs1180564328 1638 dbSNP
rs1346385370 1641 dbSNP
rs1321086654 1645 dbSNP
rs1404377207 1646 dbSNP
rs1263968059 1647 dbSNP
rs191438141 1660 dbSNP
rs572394902 1661 dbSNP
rs537214145 1669 dbSNP
rs886926742 1670 dbSNP
rs1170055644 1672 dbSNP
rs1489270044 1674 dbSNP
rs1005663178 1679 dbSNP
rs1017026929 1680 dbSNP
rs1290810616 1680 dbSNP
rs905226358 1682 dbSNP
rs976450386 1684 dbSNP
rs1002218139 1688 dbSNP
rs772258245 1690 dbSNP
rs183614455 1693 dbSNP
rs1176896850 1701 dbSNP
rs1277967938 1701 dbSNP
rs577361636 1701 dbSNP
rs773368297 1705 dbSNP
rs1272545748 1710 dbSNP
rs760078584 1711 dbSNP
rs546264096 1716 dbSNP
rs78825180 1724 dbSNP
rs573518273 1725 dbSNP
rs1381142218 1729 dbSNP
rs935495185 1744 dbSNP
rs766628951 1745 dbSNP
rs1423025695 1746 dbSNP
rs1052648964 1751 dbSNP
rs968171042 1754 dbSNP
rs540935760 1755 dbSNP
rs1013838254 1767 dbSNP
rs1195657122 1785 dbSNP
rs1456660745 1792 dbSNP
rs1257804720 1801 dbSNP
rs776802522 1803 dbSNP
rs1323214115 1811 dbSNP
rs1277068311 1832 dbSNP
rs1219177174 1833 dbSNP
rs942403140 1836 dbSNP
rs905514783 1838 dbSNP
rs1262980118 1851 dbSNP
rs542139087 1851 dbSNP
rs975122696 1856 dbSNP
rs922231398 1858 dbSNP
rs1331753034 1861 dbSNP
rs1463295349 1862 dbSNP
rs562380868 1867 dbSNP
rs145224727 1883 dbSNP
rs1175200502 1890 dbSNP
rs1414975324 1895 dbSNP
rs564393656 1899 dbSNP
rs1027404968 1908 dbSNP
rs1438036253 1914 dbSNP
rs565643587 1921 dbSNP
rs1237841445 1924 dbSNP
rs518994 1932 dbSNP
rs886979232 1933 dbSNP
rs765657622 1934 dbSNP
rs665719 1940 dbSNP
rs518962 1945 dbSNP
rs1200351215 1946 dbSNP
rs1210028193 1951 dbSNP
rs377429257 1953 dbSNP
rs532819699 1981 dbSNP
rs367652291 1982 dbSNP
rs371491566 1985 dbSNP
rs1352377648 1990 dbSNP
rs1309467699 1995 dbSNP
rs1392785828 2006 dbSNP
rs1376611332 2016 dbSNP
rs1302112704 2018 dbSNP
rs1014763017 2020 dbSNP
rs1161266973 2025 dbSNP
rs400628 2028 dbSNP
rs410604 2043 dbSNP
rs905279604 2045 dbSNP
rs1345702736 2049 dbSNP
rs410597 2050 dbSNP
rs1002676923 2058 dbSNP
rs531028582 2066 dbSNP
rs1160023859 2076 dbSNP
rs1421177964 2078 dbSNP
rs376292 2086 dbSNP
rs966332826 2098 dbSNP
rs1181691323 2112 dbSNP
rs1260182141 2113 dbSNP
rs1347169919 2115 dbSNP
rs1487642634 2116 dbSNP
rs1035042832 2117 dbSNP
rs763472160 2120 dbSNP
rs1346785099 2123 dbSNP
rs1311717043 2125 dbSNP
rs550722598 2151 dbSNP
rs563047366 2152 dbSNP
rs1296210593 2155 dbSNP
rs532075194 2156 dbSNP
rs551788705 2163 dbSNP
rs1289581155 2166 dbSNP
rs1455524372 2167 dbSNP
rs751083790 2170 dbSNP
rs756798627 2171 dbSNP
rs371138863 2172 dbSNP
rs1475712375 2174 dbSNP
rs1282196431 2175 dbSNP
rs79230757 2178 dbSNP
rs74372809 2179 dbSNP
rs548201931 2184 dbSNP
rs1287023291 2185 dbSNP
rs568302735 2189 dbSNP
rs1264449703 2197 dbSNP
rs1213947963 2204 dbSNP
rs1052992472 2207 dbSNP
rs1318056613 2208 dbSNP
rs776416949 2211 dbSNP
rs189963178 2216 dbSNP
rs181228242 2218 dbSNP
rs1045325368 2219 dbSNP
rs1383959731 2220 dbSNP
rs577452392 2223 dbSNP
rs905485085 2238 dbSNP
rs1462166661 2240 dbSNP
rs1397137137 2245 dbSNP
rs1169057309 2249 dbSNP
rs1465541305 2256 dbSNP
rs1374183735 2263 dbSNP
rs3781975 2272 dbSNP
rs1195989274 2282 dbSNP
rs749193795 2284 dbSNP
rs768673505 2285 dbSNP
rs1266066676 2290 dbSNP
rs887485603 2293 dbSNP
rs539927168 2304 dbSNP
rs1004655069 2307 dbSNP
rs1015144146 2308 dbSNP
rs933641669 2309 dbSNP
rs982730269 2315 dbSNP
rs1339870640 2316 dbSNP
rs1408357578 2317 dbSNP
rs908468014 2326 dbSNP
rs965892351 2330 dbSNP
rs1418444189 2332 dbSNP
rs1300756762 2338 dbSNP
rs553434196 2349 dbSNP
rs1373528151 2353 dbSNP
rs1329685910 2365 dbSNP
rs1446451440 2369 dbSNP
rs1258246826 2376 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000278836.5 | 3UTR | AAAUGGGAAAGGGAAUUGCUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
27 hsa-miR-378f Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT463100 ZNF609 zinc finger protein 609 2 2
MIRT469371 REST RE1 silencing transcription factor 2 6
MIRT495441 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT513606 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT520414 TXNL1 thioredoxin like 1 2 4
MIRT525111 PRKD2 protein kinase D2 2 2
MIRT525979 SPA17 sperm autoantigenic protein 17 2 2
MIRT527002 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT529215 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT529835 ARGFX arginine-fifty homeobox 2 2
MIRT532300 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT537577 ESYT2 extended synaptotagmin 2 2 2
MIRT543140 AKT1 AKT serine/threonine kinase 1 2 2
MIRT554924 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT564970 WTAP WT1 associated protein 2 2
MIRT570115 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT652734 TGFB2 transforming growth factor beta 2 2 2
MIRT655948 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT655997 MYRF myelin regulatory factor 2 2
MIRT684875 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT692969 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693737 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT710991 PPARGC1B PPARG coactivator 1 beta 2 2
MIRT712247 RCC2 regulator of chromosome condensation 2 2 2
MIRT718602 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT723499 WDR33 WD repeat domain 33 2 2
MIRT725448 HIPK3 homeodomain interacting protein kinase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-378f Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-378f Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-mir-378f Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)

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