pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MFSD6   
Synonyms MMR2, hMMR2
Description major facilitator superfamily domain containing 6
Transcript NM_017694   
Expression
Putative miRNA Targets on MFSD6
3'UTR of MFSD6
(miRNA target sites are highlighted)
>MFSD6|NM_017694|3'UTR
   1 GGGCATCCTGCTCATCTCACACCCTGCATGGAATCAGGCTCCTCAGCCAGGACACAGGGTGAGGCCCCCCAGCCAGGATA
  81 TGCCTCCCCTGGAGGAGCACAGCACTGCATATGCTTCTAAATATCTAAACTCATTAACATGGAAACACACACACAGGAGC
 161 TACAGTACATATTGGCAGGAAAAGGTAAACTTTCGTAATCTCATTGGAATTACAACAGGGAAATGGAGTTCAATGAGGAC
 241 TTTCAGTTCTTTGCTTGGTTAGGTTAAGGATGATAGAATTTCTCTGCCAGTGCAGTAAGAGTTGAAACCGGCAGTTACAC
 321 TAAGTAAGTGGAGGGAATGAAAGTGTTTCGAGGTGAATGTGGATATAATTTCCCTCTTCTGATTATTTATTCTTATTTGG
 401 TTCCTAACACAAACTGGGAAGAGATAGAATTCATCTATACTTTCTTTTTTCTTGGAGAGAACCGTTTAAAAAATTACAAG
 481 ATATATTTAAAAAGTAACCAGATAAAAGTAGCACATGTGCTTTTGTTAAAAATAAAGTTAAAAGTTAAAGTTAAAAAATG
 561 AAGTTAAAAGTTTCATCAGAAACTTTACATATCTTTAGCAAATATATTTTTATATGTGTATGGCATATAATGGAAATAAT
 641 TCTTTGAGCAACAGAAGCTATTATTAACTACTGCAAGCTAAGCCGAGCTTAAAAATGCCTTTTGTTTTAAATGGGCTTTG
 721 AGAAAAAAAACAGAAACAAGCGATTATTTCAAATCAACCAACCAACTCAGTATCCTGTGTTTTGATAGACAAGAGTTTAC
 801 TAAATATATTGATACTGTAAATAGCCTCTCTCGCTATTTACTATCTTATAGTAATTCAGGCTCTAATTAGCTGAGGGAAT
 881 GAAACACACAAAAATCACTGAATTCCTAAGAGTTCCTTAAATAAGCAGTACTAGTTACAAATCACAGTATAAGATTTAAG
 961 TGCCTGGGGGAAGGATACAATTTTTAGAAATTACATATTGGGTCAGTTTTGTTTTGTTTTTGGTGAGGAAAAGGTGGTAA
1041 ATAGGAAACCATGAATGGGAAGGATGGCAATAAGTAGCAACTATACTTTCCAATGACTAAAGAAAGAAAATCTCAGTATA
1121 TTCGTTCTCATGAAGACACAGTCAGACACTGGACAATGTAATGTATGCAACTGCAAACGTTACAACTGCAGCCAGAACAA
1201 TGGCTGGGTGGATCGCACGTAAAGCTTGCCACTAAAAATCAAAGCAGAGGTTAACAGGAAACCTGGGGGGAGTGTGGAAA
1281 AGGGAAAACTGTTTTAGCTGAATAAAGGTGAATTATATAATTTATAATAGCTGTGGATGAGCACAGGAGAGAGAGGAAAG
1361 AAAAGAACAGTCGAAATGAGCAACTCACCTTACCCTCTGACCCTGATTAGACAGGATCAATTGTAAAGTGAGGGCTTCTC
1441 CATGACACCATAGTTCTGCCCAATACTGCATTTGGGATAAGAAATTCTACACTTGGATGTCTCGCTTCACAATAAAACAC
1521 AGCTTAAAAATAAAATAACTGAAAGAAATAGAATTCAGCAAATAGTTATTTTTTGCACTTGAACTGAAACGTACTGTACT
1601 GTAAATTATGACTCATTTTAAGTGACCTTTAAAATCAGATGTATTTATTATGCTTGTGTAATTATAGAAATAAAGAAATG
1681 GGTGACAGGCTTAACCTCACCTATGAATGTACAGTATGTGGATTTGTGAAACTGACTGTAGGAAGTCAAAAACTTGTACT
1761 GTATCTTGTGTTTACAGTTCTGATTTATTCCTTTGAAAAGCCTGCTGTTTTGGAAATGCACAGTTGACATGTTGAAATAA
1841 AAATGAATACCATTTTTAAATGTTTCTTAAATGATAAAGATGTGACCAAACAAAAGTCCTATACTCTAATGAATGAGACC
1921 AAATTCAACATGCCTTTGTTATGGAACATTTACTGTGACAGCAGAATCGATAATGCAGTCATTTCCAGCCTTGTGAGCTG
2001 ACACCTTCATGGGTTTGTGGACTTTGTGACTTTTTCTTCCTGTCCCCAAAGTGCCATATGCTACCTTAAAAAATATTAAA
2081 GTGAATTCAAATTACAT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agaUUGUGGUGUCACACCAAAc 5'
             |::| |||| |||| ||| 
Target 5' aaaAGTAGCACA-TGTGCTTTt 3'
504 - 524 134.00 -9.60
2
miRNA  3' agaUUGUGGUGUC--ACACCAAAc 5'
             ||:: :||||  ||||| || 
Target 5' atgAATG-TACAGTATGTGGATTt 3'
1703 - 1725 128.00 -11.20
3
miRNA  3' agaUUG--UGGU---GUC-----ACACCAAAc 5'
             |||  ||||   |||     |||| ||| 
Target 5' atcAACCAACCAACTCAGTATCCTGTGTTTTg 3'
753 - 784 125.00 -9.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30148099 45 COSMIC
COSN31593131 71 COSMIC
COSN30532272 128 COSMIC
COSN17076513 275 COSMIC
COSN6160318 1325 COSMIC
COSN31556210 1613 COSMIC
COSN28767098 1636 COSMIC
COSN1813999 1638 COSMIC
COSN31490816 1666 COSMIC
COSN31533183 1814 COSMIC
COSN7153343 1956 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs138926881 3 dbSNP
rs371140826 6 dbSNP
rs746963765 9 dbSNP
rs770934125 12 dbSNP
rs781165134 17 dbSNP
rs1310879421 23 dbSNP
rs199987141 24 dbSNP
rs1346530134 25 dbSNP
rs769888840 29 dbSNP
rs775845991 36 dbSNP
rs1314680905 42 dbSNP
rs1464024731 44 dbSNP
rs544205749 48 dbSNP
rs1256275882 49 dbSNP
rs1288112253 54 dbSNP
rs867145251 61 dbSNP
rs1028052005 65 dbSNP
rs953700452 66 dbSNP
rs1300282117 67 dbSNP
rs1420531092 71 dbSNP
rs562510153 78 dbSNP
rs1435461206 83 dbSNP
rs531229116 85 dbSNP
rs761264098 86 dbSNP
rs546550151 88 dbSNP
rs1487522138 98 dbSNP
rs1019860851 99 dbSNP
rs61742316 100 dbSNP
rs980227684 108 dbSNP
rs978376296 112 dbSNP
rs374143867 116 dbSNP
rs1211578766 120 dbSNP
rs957261623 125 dbSNP
rs936842014 133 dbSNP
rs1228140193 141 dbSNP
rs1294788736 141 dbSNP
rs528703396 142 dbSNP
rs988723905 147 dbSNP
rs1278591099 148 dbSNP
rs1400890341 149 dbSNP
rs1375037351 151 dbSNP
rs1301271904 155 dbSNP
rs1467671251 169 dbSNP
rs1305434379 170 dbSNP
rs1206225727 171 dbSNP
rs879871382 173 dbSNP
rs61743479 180 dbSNP
rs1311058919 181 dbSNP
rs987193726 187 dbSNP
rs1467685875 189 dbSNP
rs986614948 195 dbSNP
rs568547675 196 dbSNP
rs1254816698 202 dbSNP
rs188158647 205 dbSNP
rs1224971679 229 dbSNP
rs1201759219 234 dbSNP
rs1483293139 242 dbSNP
rs949407630 250 dbSNP
rs1196733121 255 dbSNP
rs529406315 258 dbSNP
rs1258508474 275 dbSNP
rs907876502 285 dbSNP
rs1167141905 286 dbSNP
rs536900740 287 dbSNP
rs768444137 290 dbSNP
rs898313045 300 dbSNP
rs1330749237 309 dbSNP
rs550556798 311 dbSNP
rs1403046394 314 dbSNP
rs1038858458 317 dbSNP
rs1461260989 317 dbSNP
rs889571064 320 dbSNP
rs1459947797 321 dbSNP
rs1007981654 330 dbSNP
rs1328449216 341 dbSNP
rs1249262929 349 dbSNP
rs898529963 350 dbSNP
rs115461928 351 dbSNP
rs1238732521 358 dbSNP
rs1212932900 366 dbSNP
rs1354003524 367 dbSNP
rs1047366850 376 dbSNP
rs1247336473 382 dbSNP
rs1322533994 383 dbSNP
rs1430406436 391 dbSNP
rs896756879 408 dbSNP
rs1013817974 413 dbSNP
rs1000163178 418 dbSNP
rs1332635585 419 dbSNP
rs550747909 426 dbSNP
rs7419755 432 dbSNP
rs1165340537 440 dbSNP
rs958181895 450 dbSNP
rs1273352860 454 dbSNP
rs991022213 460 dbSNP
rs539331286 464 dbSNP
rs145748674 465 dbSNP
rs905321328 469 dbSNP
rs1001332827 480 dbSNP
rs1193008107 482 dbSNP
rs1033168093 491 dbSNP
rs957089772 514 dbSNP
rs1210182337 516 dbSNP
rs148940730 519 dbSNP
rs1238160477 533 dbSNP
rs1468835926 533 dbSNP
rs1356027722 536 dbSNP
rs907841761 541 dbSNP
rs1019885560 548 dbSNP
rs1240130433 550 dbSNP
rs955299239 564 dbSNP
rs192868873 575 dbSNP
rs1326059458 580 dbSNP
rs986639461 581 dbSNP
rs1036895766 583 dbSNP
rs369066043 584 dbSNP
rs1295972014 586 dbSNP
rs764843558 590 dbSNP
rs1421137817 594 dbSNP
rs974212299 613 dbSNP
rs919984299 622 dbSNP
rs1049510199 638 dbSNP
rs889636665 640 dbSNP
rs1379333685 646 dbSNP
rs1199426116 655 dbSNP
rs1008364961 666 dbSNP
rs930019461 670 dbSNP
rs1417434215 685 dbSNP
rs370343639 686 dbSNP
rs1047105492 716 dbSNP
rs373028020 717 dbSNP
rs1286879787 723 dbSNP
rs949620637 724 dbSNP
rs1342895804 728 dbSNP
rs1277127933 731 dbSNP
rs1234526604 732 dbSNP
rs1045725381 738 dbSNP
rs555129484 742 dbSNP
rs1400609480 743 dbSNP
rs905395743 745 dbSNP
rs1333051993 748 dbSNP
rs1412283061 751 dbSNP
rs1316912895 758 dbSNP
rs1403649288 780 dbSNP
rs777336922 782 dbSNP
rs1054234852 787 dbSNP
rs1421271453 787 dbSNP
rs1195534062 791 dbSNP
rs1431936984 794 dbSNP
rs1278369093 802 dbSNP
rs958316906 810 dbSNP
rs760067813 828 dbSNP
rs1440772432 829 dbSNP
rs573672056 831 dbSNP
rs1201593542 833 dbSNP
rs184487238 834 dbSNP
rs1256606688 841 dbSNP
rs556175847 844 dbSNP
rs763181821 850 dbSNP
rs1341804226 864 dbSNP
rs1334222079 869 dbSNP
rs1465074685 884 dbSNP
rs1398063249 896 dbSNP
rs1172668203 899 dbSNP
rs556798935 901 dbSNP
rs114502914 907 dbSNP
rs145631753 910 dbSNP
rs963932557 911 dbSNP
rs1471927977 913 dbSNP
rs189507503 921 dbSNP
rs931196390 929 dbSNP
rs919739276 937 dbSNP
rs1474329774 939 dbSNP
rs200931500 950 dbSNP
rs1201010140 954 dbSNP
rs982826715 963 dbSNP
rs943909925 980 dbSNP
rs917964694 991 dbSNP
rs1284381424 996 dbSNP
rs1445427114 1009 dbSNP
rs1041181442 1012 dbSNP
rs1469751146 1029 dbSNP
rs757944760 1030 dbSNP
rs540810488 1034 dbSNP
rs73979258 1038 dbSNP
rs1053412602 1039 dbSNP
rs529366066 1043 dbSNP
rs1162410655 1045 dbSNP
rs550694772 1049 dbSNP
rs1312623168 1052 dbSNP
rs1045349008 1057 dbSNP
rs1164399895 1057 dbSNP
rs1012479239 1059 dbSNP
rs926849822 1064 dbSNP
rs1412526100 1071 dbSNP
rs562507873 1075 dbSNP
rs936916139 1084 dbSNP
rs1481233075 1085 dbSNP
rs373798575 1089 dbSNP
rs1246531437 1090 dbSNP
rs1054377370 1092 dbSNP
rs1453633669 1094 dbSNP
rs751772518 1097 dbSNP
rs779624528 1099 dbSNP
rs1238887894 1104 dbSNP
rs1350949822 1107 dbSNP
rs1340482403 1124 dbSNP
rs1310792030 1125 dbSNP
rs1240853444 1128 dbSNP
rs1366784987 1131 dbSNP
rs1291675618 1133 dbSNP
rs1237727772 1136 dbSNP
rs1277652140 1137 dbSNP
rs1438375352 1139 dbSNP
rs1350194776 1147 dbSNP
rs1303986117 1149 dbSNP
rs1352784601 1163 dbSNP
rs533176041 1167 dbSNP
rs1279309928 1177 dbSNP
rs1484599010 1179 dbSNP
rs750979593 1180 dbSNP
rs1015420571 1183 dbSNP
rs138175515 1184 dbSNP
rs1179774620 1186 dbSNP
rs973465937 1200 dbSNP
rs1287594606 1201 dbSNP
rs890820310 1207 dbSNP
rs1294243404 1210 dbSNP
rs1027584320 1213 dbSNP
rs953398423 1215 dbSNP
rs1008287832 1216 dbSNP
rs367642212 1219 dbSNP
rs976654462 1220 dbSNP
rs750365736 1222 dbSNP
rs1174651880 1247 dbSNP
rs1416639473 1248 dbSNP
rs1430485975 1250 dbSNP
rs1193358955 1257 dbSNP
rs34750665 1257 dbSNP
rs1477024705 1261 dbSNP
rs143086708 1268 dbSNP
rs1393653507 1273 dbSNP
rs1026824036 1276 dbSNP
rs549137628 1290 dbSNP
rs1253738346 1292 dbSNP
rs982901732 1303 dbSNP
rs1025052355 1304 dbSNP
rs1212227300 1306 dbSNP
rs1175070216 1309 dbSNP
rs1402502858 1316 dbSNP
rs935036163 1328 dbSNP
rs1257300524 1332 dbSNP
rs970741286 1333 dbSNP
rs1326241221 1341 dbSNP
rs567394722 1349 dbSNP
rs926617006 1352 dbSNP
rs561086361 1367 dbSNP
rs1378606946 1369 dbSNP
rs145145666 1370 dbSNP
rs779805669 1373 dbSNP
rs1407514116 1374 dbSNP
rs1464407758 1389 dbSNP
rs914104527 1391 dbSNP
rs556300275 1393 dbSNP
rs906824028 1395 dbSNP
rs1004205854 1401 dbSNP
rs945534994 1402 dbSNP
rs1253527739 1408 dbSNP
rs1183126102 1409 dbSNP
rs1041471137 1416 dbSNP
rs573241830 1418 dbSNP
rs1256758181 1419 dbSNP
rs943770987 1421 dbSNP
rs1196606075 1429 dbSNP
rs994859030 1430 dbSNP
rs1194343757 1439 dbSNP
rs1027719556 1443 dbSNP
rs1228489774 1460 dbSNP
rs1039784227 1463 dbSNP
rs1321313143 1468 dbSNP
rs953367108 1470 dbSNP
rs986130738 1473 dbSNP
rs899460848 1495 dbSNP
rs1183194226 1501 dbSNP
rs995870437 1504 dbSNP
rs754753741 1505 dbSNP
rs1399158544 1507 dbSNP
rs1455821916 1517 dbSNP
rs1457683062 1522 dbSNP
rs1194690373 1540 dbSNP
rs1372905443 1550 dbSNP
rs749694006 1555 dbSNP
rs1026898462 1556 dbSNP
rs1461151055 1557 dbSNP
rs191159246 1561 dbSNP
rs778776629 1564 dbSNP
rs956547635 1569 dbSNP
rs1459014828 1577 dbSNP
rs989213557 1586 dbSNP
rs1209057241 1591 dbSNP
rs1465693294 1591 dbSNP
rs1325073460 1597 dbSNP
rs553524801 1602 dbSNP
rs34069143 1616 dbSNP
rs1360344923 1619 dbSNP
rs1004031195 1623 dbSNP
rs1024790650 1627 dbSNP
rs947698732 1628 dbSNP
rs7721 1636 dbSNP
rs1308274512 1644 dbSNP
rs1386576438 1666 dbSNP
rs980845932 1671 dbSNP
rs148360239 1680 dbSNP
rs1253300830 1690 dbSNP
rs1443448020 1700 dbSNP
rs1424884330 1706 dbSNP
rs1359395763 1709 dbSNP
rs866567601 1714 dbSNP
rs1440955406 1722 dbSNP
rs565159192 1731 dbSNP
rs1213173725 1741 dbSNP
rs1271782842 1743 dbSNP
rs1269201624 1756 dbSNP
rs1382689303 1756 dbSNP
rs1470199302 1758 dbSNP
rs989718823 1760 dbSNP
rs1285453167 1761 dbSNP
rs1128723 1764 dbSNP
rs1352854422 1767 dbSNP
rs945606655 1769 dbSNP
rs574162989 1771 dbSNP
rs1233155215 1779 dbSNP
rs1329766701 1780 dbSNP
rs1285555085 1782 dbSNP
rs897980892 1786 dbSNP
rs1339476324 1791 dbSNP
rs1295912394 1796 dbSNP
rs1401954271 1802 dbSNP
rs375934842 1802 dbSNP
rs1427174374 1803 dbSNP
rs1171999115 1808 dbSNP
rs1464472652 1814 dbSNP
rs1431226816 1823 dbSNP
rs987610289 1825 dbSNP
rs1049127955 1833 dbSNP
rs1191691327 1839 dbSNP
rs1425341622 1843 dbSNP
rs1477834007 1851 dbSNP
rs1285029180 1852 dbSNP
rs1200432845 1853 dbSNP
rs1343448804 1855 dbSNP
rs912025051 1861 dbSNP
rs1224531400 1868 dbSNP
rs943786853 1874 dbSNP
rs1391698844 1875 dbSNP
rs1462938513 1885 dbSNP
rs1039453648 1888 dbSNP
rs116319890 1893 dbSNP
rs562664275 1894 dbSNP
rs930983789 1919 dbSNP
rs551298031 1920 dbSNP
rs1297940881 1932 dbSNP
rs966456044 1933 dbSNP
rs1394261736 1940 dbSNP
rs1408253448 1942 dbSNP
rs1176996200 1944 dbSNP
rs775697044 1945 dbSNP
rs1232944725 1946 dbSNP
rs1291490708 1954 dbSNP
rs1421201141 1960 dbSNP
rs1166430975 1969 dbSNP
rs887042844 1979 dbSNP
rs1242814020 1985 dbSNP
rs1337115664 1987 dbSNP
rs538672689 1987 dbSNP
rs1186967689 1988 dbSNP
rs1222938420 1992 dbSNP
rs563171228 1996 dbSNP
rs1245529369 2000 dbSNP
rs1485063913 2003 dbSNP
rs956515440 2013 dbSNP
rs1024822116 2018 dbSNP
rs1256551184 2022 dbSNP
rs57946998 2027 dbSNP
rs143693476 2031 dbSNP
rs546802386 2031 dbSNP
rs980941303 2041 dbSNP
rs927627559 2044 dbSNP
rs1488394614 2046 dbSNP
rs1445936823 2049 dbSNP
rs939039439 2050 dbSNP
rs1033755625 2052 dbSNP
rs549047344 2057 dbSNP
rs1410279878 2066 dbSNP
rs1420517864 2073 dbSNP
rs1010880252 2077 dbSNP
rs1415016556 2079 dbSNP
rs1162827081 2096 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agauuguggugUCACACCAAAc 5'
                     :| ||||||| 
Target 5' ----gaaagggGGAGUGGUUU- 3'
1 - 17
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000392328.1 | 3UTR | AAAAGGGGUGAAAGGGGGAGUGGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000392328.1 | 3UTR | GAAAGGGGGAGUGGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.622 5.9e-4 0.559 2.3e-3 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.444 1.7e-2 0.164 2.3e-1 23 Click to see details
GSE32688 Pancreatic cancer 0.359 2.2e-2 0.294 5.1e-2 32 Click to see details
GSE28260 Renal cortex and medulla 0.562 2.3e-2 0.367 1.1e-1 13 Click to see details
GSE19350 CNS germ cell tumors -0.504 4.7e-2 0.035 4.6e-1 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.28 8.8e-2 -0.231 1.3e-1 25 Click to see details
GSE26953 Aortic valvular endothelial cells -0.096 3.3e-1 -0.044 4.2e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.099 3.4e-1 -0.540 7.0e-3 20 Click to see details
GSE21687 Ependynoma primary tumors -0.036 3.9e-1 -0.026 4.2e-1 64 Click to see details
GSE38226 Liver fibrosis -0.016 4.7e-1 -0.156 2.5e-1 21 Click to see details
GSE38226 Liver fibrosis -0.016 4.7e-1 -0.156 2.5e-1 21 Click to see details
GSE38226 Liver fibrosis -0.016 4.7e-1 -0.156 2.5e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.421 0.05 -0.353 0.09 16 Click to see details
KICH -0.375 0.08 -0.229 0.21 15 Click to see details
BRCA 0.211 0.09 0.241 0.06 42 Click to see details
BLCA -0.805 0.1 -0.200 0.4 4 Click to see details
HNSC 0.269 0.14 0.154 0.27 18 Click to see details
THCA -0.164 0.14 -0.121 0.21 45 Click to see details
CHOL -0.493 0.16 -0.657 0.08 6 Click to see details
KIRC -0.129 0.2 -0.101 0.26 43 Click to see details
STAD -0.169 0.23 -0.230 0.16 21 Click to see details
PRAD 0.088 0.28 0.020 0.45 46 Click to see details
KIRP -0.126 0.29 -0.118 0.31 21 Click to see details
LIHC -0.086 0.33 0.084 0.33 30 Click to see details
PAAD 0.291 0.35 0.600 0.2 4 Click to see details
LUAD -0.211 0.39 0.000 0.5 4 Click to see details
LUSC -0.036 0.43 0.032 0.43 30 Click to see details
ESCA -0.061 0.43 -0.321 0.18 10 Click to see details
ESCA -0.061 0.43 -0.321 0.18 10 Click to see details
ESCA -0.061 0.43 -0.321 0.18 10 Click to see details
ESCA -0.061 0.43 -0.321 0.18 10 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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