>MAPK6|NM_002748|3'UTR
   1 AACACTCAGCAGACATTTATCTTTGTATTCTTCATGAAATGTGTTTTGTCTTTTTTTATTACTAGTGTTTAAGTCATTTT
  81 TTACTTGAATCAGATGGTGTCATTTAGTAAGGATTTTATGAGTTCTTGTTTTTTAAAATCCAGACTTTCTTTTTCTACAT
 161 GTGAGATAGTTTTCATTTTAACTGGCATGTCATTTGCACACAAAAATAAAGACTAGAGCAAAATAATGCAACGCAGGAGG
 241 AGAAAAGAAATGCACTAAGACAAGAACATTCTCTCATAGAACATTGATCTGTTTTACAGGAAACAAACCTTGCCTTGAAA
 321 TTTACACAGTGAGACTGTACATAATTGCATGAAAATAGCTATTTTTTTCCTAAGACATTTTTCATTCATGAATATTTTCA
 401 AGTTTTTCATACTGTACACATTTCTTAAAACACATGATACCAGCAGCAACTGAAAATGAATGCCGAATTTGGTACACATG
 481 TGTTATCTACCTCAAGGTAACAAGAGTATGTGGCAAAACATATACCACCCATAGTGCTTCACAAAATGCACTTCTATTTA
 561 GCCAGCGTTTATTGTAGTAAACTATTCTTAATAAAACTCACTCACTGTTTATAAATGTTCTGGTATGCATTCTTTATAGT
 641 GAAGTGTTAATACATCACATCTTATTTATTTTAGCAAATCAGTATATTTTCTGTATTTAATTATAAAAAATTAACTTAGT
 721 TTTTAAAATTTATTTGCAAATATACTTTACTTTTTCCATTTGGCACTATGGTTTGTTGCCTACCTAGCTGCATCTATAAT
 801 GTCAGCTTATCCTAAGGCTGTCCACGTACTTAATTTACTTAAGTGTTCATTTTAAGTAACGTGCTCACTGTGTATAGGAA
 881 TTTGTATTTTGGAGGTGCTTGATCTATCTACAAAGAAAAATTAATTAGGAATTACTTTATTATAAAATGCTCCTAGAAGT
 961 CTTAATTGTGTTTATTTTTTAAAAAAACAAATGTTAGACTTGTGTGCATGGAAGTAATTAAGGTACATCATTATTGTAGT
1041 TTGAAAGTTGTACATGATAAGACATTTTGTTTTTACTGTATGTTTTTACTGAATGATCTATTCCCCATCCCAAGGCAAGC
1121 ATGAATAAAATTAGGTTAAACGTAGCATGTGGCATCGCAGTCTCTTAGAATTTGTTTCATCTATTTTATTTTATTGAATA
1201 CTGTCTGTATCTTTGGTTATCCTGTTTGAAGAAAAAGGACAAATAAAACATGGCCAGCAAATACA

ID	Duplex structure	Position	Score	MFE
1	miRNA 3' uggucaACGGAGAU-GUCAGAAau 5' |||: ||| |||||| Target 5' ataaaaTGCTCCTAGAAGTCTTaa 3'	942 - 965	137.00	-11.40
2	miRNA 3' ugGU-CAACGGAGAUGUCAGAAAu 5' || || || || :|||||| | Target 5' agCATGTGGCATC-GCAGTCTCTt 3'	1144 - 1166	132.00	-11.92
3	miRNA 3' uggUCAACGGAGAUGUCAGAAAu 5' | || || :|||:||| Target 5' aaaAATTAACT---TAGTTTTTa 3'	706 - 725	129.00	-6.60

Mutant ID	Mutant Position	Mutant Source
COSN31601993	22	COSMIC
COSN30153206	51	COSMIC
COSN30144000	63	COSMIC
COSN31600375	169	COSMIC
COSN26575978	338	COSMIC
COSN31548453	352	COSMIC
COSN31488824	388	COSMIC
COSN31585151	577	COSMIC
COSN31480616	642	COSMIC
COSN20112067	750	COSMIC
COSN19168490	846	COSMIC
COSN20112072	989	COSMIC
COSN8174503	1109	COSMIC
COSN30539236	1151	COSMIC
COSN31553571	1158	COSMIC
COSN6275359	1258	COSMIC
COSN21875704	1337	COSMIC
COSN23124731	1509	COSMIC
COSN18834407	1734	COSMIC
COSN18752709	1736	COSMIC
COSN20380761	1763	COSMIC
COSN16169897	1795	COSMIC
COSN1177790	1922	COSMIC
COSN23306897	1933	COSMIC
COSN20969335	1947	COSMIC
COSN6275360	2277	COSMIC

Mutant ID	Mutant Position	Mutant Source
rs1433532440	7	dbSNP
rs747303169	8	dbSNP
rs776858835	11	dbSNP
rs762112281	14	dbSNP
rs750436527	16	dbSNP
rs780866438	16	dbSNP
rs1162307566	18	dbSNP
rs1475597197	20	dbSNP
rs1243639233	22	dbSNP
rs765602869	25	dbSNP
rs1348032740	28	dbSNP
rs150964739	31	dbSNP
rs1254694603	32	dbSNP
rs1214444460	37	dbSNP
rs763500374	38	dbSNP
rs766052988	41	dbSNP
rs953532096	43	dbSNP
rs1226818221	46	dbSNP
rs1272302171	46	dbSNP
rs1340409847	46	dbSNP
rs751119360	47	dbSNP
rs1365190365	48	dbSNP
rs755089719	48	dbSNP
rs754477873	49	dbSNP
rs373807466	51	dbSNP
rs748273542	51	dbSNP
rs756356623	51	dbSNP
rs781466558	51	dbSNP
rs1473118872	58	dbSNP
rs1421377223	62	dbSNP
rs1166557907	63	dbSNP
rs1395672578	68	dbSNP
rs568843424	68	dbSNP
rs1406345939	71	dbSNP
rs911167500	76	dbSNP
rs539555242	77	dbSNP
rs1245056682	84	dbSNP
rs1221033098	88	dbSNP
rs1438664415	102	dbSNP
rs1157689646	103	dbSNP
rs1203500145	104	dbSNP
rs1303335046	112	dbSNP
rs1341925617	116	dbSNP
rs1304756913	117	dbSNP
rs1349929222	119	dbSNP
rs557873234	121	dbSNP
rs1346263465	123	dbSNP
rs1273794905	124	dbSNP
rs1406297951	126	dbSNP
rs1300893081	129	dbSNP
rs1442480118	129	dbSNP
rs1344556518	134	dbSNP
rs941246783	143	dbSNP
rs531208072	145	dbSNP
rs769651405	146	dbSNP
rs530362329	148	dbSNP
rs1281085979	150	dbSNP
rs1423136878	152	dbSNP
rs1190750917	158	dbSNP
rs1470617149	160	dbSNP
rs1203319729	163	dbSNP
rs1491390728	163	dbSNP
rs1281511843	164	dbSNP
rs1491192578	164	dbSNP
rs1311028555	165	dbSNP
rs1277259819	167	dbSNP
rs56216817	168	dbSNP
rs1223906410	169	dbSNP
rs1351825830	170	dbSNP
rs929728133	174	dbSNP
rs577542797	183	dbSNP
rs1223113190	190	dbSNP
rs1045533208	191	dbSNP
rs1290564841	197	dbSNP
rs906940844	200	dbSNP
rs879338847	202	dbSNP
rs1175421778	204	dbSNP
rs565725930	204	dbSNP
rs1414285207	207	dbSNP
rs1483509959	207	dbSNP
rs1180216709	210	dbSNP
rs1258653826	214	dbSNP
rs1472421645	214	dbSNP
rs1001643279	218	dbSNP
rs1482552015	220	dbSNP
rs1184360367	228	dbSNP
rs191401127	233	dbSNP
rs893382467	234	dbSNP
rs1011797984	235	dbSNP
rs184104841	241	dbSNP
rs1227381504	246	dbSNP
rs967542398	250	dbSNP
rs767719939	251	dbSNP
rs575080376	253	dbSNP
rs775663369	256	dbSNP
rs1364507300	259	dbSNP
rs1430028115	260	dbSNP
rs542128701	261	dbSNP
rs953486030	262	dbSNP
rs187774960	264	dbSNP
rs779692504	265	dbSNP
rs1390910845	270	dbSNP
rs1157122326	272	dbSNP
rs760726234	278	dbSNP
rs909179341	280	dbSNP
rs1422397705	285	dbSNP
rs1255905395	295	dbSNP
rs1187551197	301	dbSNP
rs1441282658	301	dbSNP
rs1284704347	305	dbSNP
rs962958973	308	dbSNP
rs1207599056	310	dbSNP
rs1384907974	313	dbSNP
rs1243792643	319	dbSNP
rs1314484321	323	dbSNP
rs748726924	324	dbSNP
rs973960632	326	dbSNP
rs1343084043	328	dbSNP
rs1197748199	331	dbSNP
rs918490712	334	dbSNP
rs1362997538	335	dbSNP
rs1485569725	336	dbSNP
rs929826306	336	dbSNP
rs1271212584	350	dbSNP
rs1391588629	354	dbSNP
rs3542	356	dbSNP
rs541380271	357	dbSNP
rs1437600132	362	dbSNP
rs1368237555	367	dbSNP
rs1171638404	368	dbSNP
rs1211352639	369	dbSNP
rs1388913301	370	dbSNP
rs1188510594	372	dbSNP
rs1245438102	373	dbSNP
rs1268857904	379	dbSNP
rs768193869	381	dbSNP
rs575216815	388	dbSNP
rs928414288	388	dbSNP
rs1207098034	389	dbSNP
rs937068098	391	dbSNP
rs560295245	392	dbSNP
rs58936667	393	dbSNP
rs1234941781	398	dbSNP
rs1331690165	400	dbSNP
rs1303569142	402	dbSNP
rs1385301350	403	dbSNP
rs1390336858	403	dbSNP
rs761511932	403	dbSNP
rs1308991880	409	dbSNP
rs1431962204	410	dbSNP
rs1369129935	413	dbSNP
rs564239957	419	dbSNP
rs1168444112	421	dbSNP
rs1478676759	423	dbSNP
rs892774230	427	dbSNP
rs1475482855	431	dbSNP
rs1196183253	435	dbSNP
rs1432215490	442	dbSNP
rs1250736882	455	dbSNP
rs1183941655	464	dbSNP
rs1012261788	466	dbSNP
rs1393966328	476	dbSNP
rs1347117840	478	dbSNP
rs570947349	478	dbSNP
rs1409084563	479	dbSNP
rs1330619570	480	dbSNP
rs1289177812	481	dbSNP
rs1449869564	483	dbSNP
rs1411903573	487	dbSNP
rs1337159007	502	dbSNP
rs1307880901	504	dbSNP
rs903438117	506	dbSNP
rs997677908	508	dbSNP
rs1171356743	515	dbSNP
rs1030417442	524	dbSNP
rs1412067296	531	dbSNP
rs1336049481	535	dbSNP
rs1471441708	536	dbSNP
rs760694207	540	dbSNP
rs1365996179	541	dbSNP
rs1250798034	545	dbSNP
rs1188444031	550	dbSNP
rs953593128	554	dbSNP
rs1253937885	557	dbSNP
rs1199834616	561	dbSNP
rs528317738	567	dbSNP
rs753795229	568	dbSNP
rs574735983	575	dbSNP
rs1338987422	577	dbSNP
rs764088230	578	dbSNP
rs1288087714	582	dbSNP
rs1449145336	585	dbSNP
rs1342665812	586	dbSNP
rs1332689853	587	dbSNP
rs567228101	589	dbSNP
rs963432992	589	dbSNP
rs750098459	596	dbSNP
rs1491267015	605	dbSNP
rs1163506654	606	dbSNP
rs1473634171	606	dbSNP
rs542142107	606	dbSNP
rs1025603832	608	dbSNP
rs1186679955	611	dbSNP
rs1248688494	613	dbSNP
rs1249251303	618	dbSNP
rs1447074153	621	dbSNP
rs1463616184	622	dbSNP
rs1267696719	623	dbSNP
rs1229103155	628	dbSNP
rs1358835602	630	dbSNP
rs1244698667	633	dbSNP
rs951276233	633	dbSNP
rs1366615785	636	dbSNP
rs1321950045	638	dbSNP
rs765073462	639	dbSNP
rs750077928	643	dbSNP
rs1323734602	646	dbSNP
rs1406753667	648	dbSNP
rs1388304241	650	dbSNP
rs563614299	659	dbSNP
rs1391883825	662	dbSNP
rs937100328	662	dbSNP
rs991231128	662	dbSNP
rs1447659239	664	dbSNP
rs546785428	666	dbSNP
rs1222562339	669	dbSNP
rs914292660	679	dbSNP
rs947087586	680	dbSNP
rs1431111475	682	dbSNP
rs1300396299	685	dbSNP
rs1343348421	685	dbSNP
rs192442196	691	dbSNP
rs1175605375	694	dbSNP
rs1363755388	694	dbSNP
rs866226546	694	dbSNP
rs1438128670	695	dbSNP
rs1322498683	697	dbSNP
rs1329044053	697	dbSNP
rs1430120440	702	dbSNP
rs1372178629	705	dbSNP
rs1166572951	706	dbSNP
rs1418882370	709	dbSNP
rs747364871	709	dbSNP
rs1479118776	710	dbSNP
rs1041361374	711	dbSNP
rs1245157235	711	dbSNP
rs1277230567	711	dbSNP
rs903447858	711	dbSNP
rs1383932304	714	dbSNP
rs1307490907	715	dbSNP
rs1176676755	716	dbSNP
rs1220403667	716	dbSNP
rs1273808958	716	dbSNP
rs933538508	716	dbSNP
rs1410065658	720	dbSNP
rs1352078097	723	dbSNP
rs1306023002	728	dbSNP
rs1316332757	729	dbSNP
rs1326024935	737	dbSNP
rs1178172559	741	dbSNP
rs1437497829	741	dbSNP
rs201116439	742	dbSNP
rs113507272	743	dbSNP
rs61501443	743	dbSNP
rs760044903	743	dbSNP
rs889264293	746	dbSNP
rs112907912	747	dbSNP
rs113707949	748	dbSNP
rs1480523716	749	dbSNP
rs1238515048	756	dbSNP
rs1212864136	757	dbSNP
rs1223350695	767	dbSNP
rs550860005	771	dbSNP
rs879689734	779	dbSNP
rs1228612678	783	dbSNP
rs1330817686	784	dbSNP
rs1286206963	788	dbSNP
rs765683272	789	dbSNP
rs768233321	791	dbSNP
rs1379664633	799	dbSNP
rs1304452263	801	dbSNP
rs1357490774	806	dbSNP
rs1336237793	812	dbSNP
rs1457937906	815	dbSNP
rs1008120109	817	dbSNP
rs1016380340	819	dbSNP
rs1418794801	824	dbSNP
rs1259091247	826	dbSNP
rs568907820	827	dbSNP
rs1241949599	830	dbSNP
rs1208866270	839	dbSNP
rs1026281651	841	dbSNP
rs1465882712	841	dbSNP
rs1322040210	842	dbSNP
rs951286020	842	dbSNP
rs532937502	843	dbSNP
rs1028744720	844	dbSNP
rs1381998306	847	dbSNP
rs757984665	850	dbSNP
rs1175452554	861	dbSNP
rs958589438	862	dbSNP
rs1318718146	864	dbSNP
rs1453385640	865	dbSNP
rs76535650	869	dbSNP
rs1350826072	875	dbSNP
rs1167396579	878	dbSNP
rs1455303267	879	dbSNP
rs991723932	885	dbSNP
rs1189814103	887	dbSNP
rs1450723226	888	dbSNP
rs1245684308	890	dbSNP
rs1204174854	899	dbSNP
rs1488642489	901	dbSNP
rs1156854333	902	dbSNP
rs748220009	902	dbSNP
rs1384309425	907	dbSNP
rs1358503112	912	dbSNP
rs914367209	913	dbSNP
rs1425444101	919	dbSNP
rs182410403	923	dbSNP
rs1343877552	925	dbSNP
rs1404658067	930	dbSNP
rs1368630269	932	dbSNP
rs1381828799	932	dbSNP
rs545706562	932	dbSNP
rs977064449	936	dbSNP
rs779558013	938	dbSNP
rs1423091734	939	dbSNP
rs924249539	944	dbSNP
rs1169723473	955	dbSNP
rs1191899878	962	dbSNP
rs1308185360	962	dbSNP
rs1387779954	962	dbSNP
rs1432234518	962	dbSNP
rs1338006165	974	dbSNP
rs933590096	975	dbSNP
rs566580743	976	dbSNP
rs1490108066	980	dbSNP
rs1325734263	981	dbSNP
rs1340017637	981	dbSNP
rs1436288837	981	dbSNP
rs1052045025	982	dbSNP
rs533605151	983	dbSNP
rs564180814	986	dbSNP
rs1303599488	989	dbSNP
rs553552149	989	dbSNP
rs1489729983	992	dbSNP
rs1198362567	1003	dbSNP
rs1038275037	1014	dbSNP
rs899252863	1015	dbSNP
rs993548702	1015	dbSNP
rs1395029626	1019	dbSNP
rs528190698	1023	dbSNP
rs568524327	1024	dbSNP
rs1173795903	1027	dbSNP
rs770579066	1030	dbSNP
rs776262691	1030	dbSNP
rs1252230017	1031	dbSNP
rs1363221053	1034	dbSNP
rs1035645011	1035	dbSNP
rs1481961213	1036	dbSNP
rs1249688110	1047	dbSNP
rs1445242994	1054	dbSNP
rs1257897536	1065	dbSNP
rs1483587223	1065	dbSNP
rs1221907178	1066	dbSNP
rs953160888	1068	dbSNP
rs1012755527	1079	dbSNP
rs1165562110	1079	dbSNP
rs1021842741	1084	dbSNP
rs1334356681	1092	dbSNP
rs1328701569	1096	dbSNP
rs1363887763	1099	dbSNP
rs1397182415	1101	dbSNP
rs1403713679	1104	dbSNP
rs1424293676	1108	dbSNP
rs968450407	1111	dbSNP
rs1468943009	1112	dbSNP
rs1399051344	1116	dbSNP
rs1160963799	1117	dbSNP
rs56367619	1122	dbSNP
rs1468351160	1126	dbSNP
rs1390087841	1133	dbSNP
rs1188153169	1134	dbSNP
rs1444132856	1138	dbSNP
rs1258314013	1142	dbSNP
rs1201904882	1143	dbSNP
rs1306913988	1145	dbSNP
rs1384193854	1147	dbSNP
rs977115302	1149	dbSNP
rs924344577	1157	dbSNP
rs1015218242	1158	dbSNP
rs1356774907	1165	dbSNP
rs1220336964	1171	dbSNP
rs753293213	1178	dbSNP
rs1322073495	1182	dbSNP
rs536177606	1182	dbSNP
rs545362054	1182	dbSNP
rs1398654796	1184	dbSNP
rs1481489378	1193	dbSNP
rs1383972284	1195	dbSNP
rs1163667874	1201	dbSNP
rs1473724220	1201	dbSNP
rs987536675	1208	dbSNP
rs1182947930	1210	dbSNP
rs910845886	1214	dbSNP
rs1248784841	1217	dbSNP
rs943581061	1220	dbSNP
rs1445536652	1225	dbSNP
rs1249661121	1229	dbSNP
rs1037884043	1232	dbSNP
rs920732451	1235	dbSNP
rs557207872	1238	dbSNP
rs1358943103	1241	dbSNP
rs929394547	1248	dbSNP
rs1245907482	1262	dbSNP
rs1028424391	1263	dbSNP
rs546534995	1265	dbSNP
rs1299269189	1267	dbSNP
rs1428184451	1274	dbSNP
rs1325540789	1281	dbSNP
rs1323832871	1291	dbSNP
rs186756728	1299	dbSNP
rs1019823899	1305	dbSNP
rs764329792	1313	dbSNP
rs1171377165	1314	dbSNP
rs961561068	1316	dbSNP
rs1390831631	1321	dbSNP
rs1169773846	1332	dbSNP
rs17540338	1337	dbSNP
rs1027200040	1341	dbSNP
rs534434187	1343	dbSNP
rs1199853658	1345	dbSNP
rs1407421829	1350	dbSNP
rs193004110	1355	dbSNP
rs1013220565	1359	dbSNP
rs1335367466	1365	dbSNP
rs561935560	1366	dbSNP
rs1379914961	1369	dbSNP
rs1338218747	1377	dbSNP
rs1275008795	1379	dbSNP
rs1227301603	1380	dbSNP
rs1021430018	1383	dbSNP
rs1295760746	1386	dbSNP
rs926941580	1390	dbSNP
rs1308906598	1392	dbSNP
rs1372274435	1396	dbSNP
rs778191168	1400	dbSNP
rs749787208	1403	dbSNP
rs959808857	1406	dbSNP
rs529063224	1407	dbSNP
rs771206369	1411	dbSNP
rs544546806	1415	dbSNP
rs1481581523	1419	dbSNP
rs1427606907	1430	dbSNP
rs1199213230	1435	dbSNP
rs141901816	1435	dbSNP
rs879543078	1435	dbSNP
rs913093889	1437	dbSNP
rs1205456246	1440	dbSNP
rs1436667203	1440	dbSNP
rs1278793627	1442	dbSNP
rs1224932542	1446	dbSNP
rs1321032634	1448	dbSNP
rs1241259578	1456	dbSNP
rs562768545	1459	dbSNP
rs1228732930	1462	dbSNP
rs1187193301	1463	dbSNP
rs1264057516	1468	dbSNP
rs140689993	1474	dbSNP
rs150078684	1476	dbSNP
rs1354010041	1477	dbSNP
rs1334982806	1479	dbSNP
rs925864255	1480	dbSNP
rs1471068378	1490	dbSNP
rs1430383650	1493	dbSNP
rs184557755	1497	dbSNP
rs1471190085	1499	dbSNP
rs965005973	1502	dbSNP
rs1405996703	1506	dbSNP
rs936673524	1506	dbSNP
rs1175981816	1508	dbSNP
rs1470109508	1510	dbSNP
rs974041179	1511	dbSNP
rs1049780903	1516	dbSNP
rs138663784	1518	dbSNP
rs190272319	1519	dbSNP
rs1208977567	1523	dbSNP
rs147104026	1524	dbSNP
rs374369077	1524	dbSNP
rs1380133742	1525	dbSNP
rs1304689102	1528	dbSNP
rs1041133283	1530	dbSNP
rs1223117455	1533	dbSNP
rs1277229267	1535	dbSNP
rs1323970918	1538	dbSNP
rs897319160	1541	dbSNP
rs1454610726	1546	dbSNP
rs920829167	1549	dbSNP
rs1336259580	1560	dbSNP
rs1225183572	1562	dbSNP
rs1261107088	1564	dbSNP
rs994314748	1565	dbSNP
rs1311548951	1566	dbSNP
rs1400512731	1567	dbSNP
rs1415108011	1578	dbSNP
rs1185964524	1583	dbSNP
rs1442173970	1584	dbSNP
rs1188802720	1585	dbSNP
rs1242049306	1585	dbSNP
rs1027664638	1589	dbSNP
rs568663965	1595	dbSNP
rs1001726129	1598	dbSNP
rs929490888	1600	dbSNP
rs1034008502	1601	dbSNP
rs1243703694	1606	dbSNP
rs1293771766	1606	dbSNP
rs1262603674	1607	dbSNP
rs201021914	1607	dbSNP
rs1382966770	1608	dbSNP
rs549828106	1610	dbSNP
rs66526307	1610	dbSNP
rs755053801	1610	dbSNP
rs1287366951	1611	dbSNP
rs34235517	1611	dbSNP
rs1430368256	1612	dbSNP
rs75737026	1613	dbSNP
rs535648378	1614	dbSNP
rs1423368219	1616	dbSNP
rs1384045279	1622	dbSNP
rs992537672	1623	dbSNP
rs1168735159	1627	dbSNP
rs1429803420	1628	dbSNP
rs1481621938	1634	dbSNP
rs939397851	1637	dbSNP
rs912945389	1642	dbSNP
rs1055145498	1645	dbSNP
rs1250970677	1648	dbSNP
rs774721388	1654	dbSNP
rs1358701208	1655	dbSNP
rs978594332	1658	dbSNP
rs746116585	1662	dbSNP
rs1228193622	1672	dbSNP
rs925758533	1676	dbSNP
rs557274888	1680	dbSNP
rs1401827497	1681	dbSNP
rs1381918950	1682	dbSNP
rs904439632	1683	dbSNP
rs1161958236	1688	dbSNP
rs772379137	1691	dbSNP
rs931915463	1692	dbSNP
rs1403616073	1696	dbSNP
rs199892604	1697	dbSNP
rs569219790	1697	dbSNP
rs998686445	1697	dbSNP
rs1299277101	1700	dbSNP
rs1050326448	1702	dbSNP
rs1031428260	1709	dbSNP
rs1370858021	1712	dbSNP
rs1451066353	1717	dbSNP
rs1169296559	1720	dbSNP
rs911266212	1726	dbSNP
rs943982177	1728	dbSNP
rs1490133811	1729	dbSNP
rs1041536518	1731	dbSNP
rs1345760825	1735	dbSNP
rs1009036305	1740	dbSNP
rs1481649171	1751	dbSNP
rs1017289695	1752	dbSNP
rs143806443	1752	dbSNP
rs371569576	1752	dbSNP
rs550172013	1752	dbSNP
rs897212098	1753	dbSNP
rs1324603200	1758	dbSNP
rs1285456751	1759	dbSNP
rs994764659	1762	dbSNP
rs1416074030	1763	dbSNP
rs1202027995	1764	dbSNP
rs1241768251	1764	dbSNP
rs1280576625	1764	dbSNP
rs1306949480	1764	dbSNP
rs1334270290	1764	dbSNP
rs1334453591	1764	dbSNP
rs1358187822	1764	dbSNP
rs1384377197	1764	dbSNP
rs1435429541	1764	dbSNP
rs144696725	1764	dbSNP
rs3222636	1764	dbSNP
rs746917875	1764	dbSNP
rs776305326	1764	dbSNP
rs964756160	1764	dbSNP
rs973053169	1764	dbSNP
rs1469029207	1765	dbSNP
rs71875062	1766	dbSNP
rs1385362138	1767	dbSNP
rs1160132997	1771	dbSNP
rs1281173016	1775	dbSNP
rs1363121444	1776	dbSNP
rs1184138234	1777	dbSNP
rs1245108049	1778	dbSNP
rs1048582470	1779	dbSNP
rs1461073122	1779	dbSNP
rs1285368346	1780	dbSNP
rs1027943371	1781	dbSNP
rs1348984987	1783	dbSNP
rs888604940	1783	dbSNP
rs983626568	1783	dbSNP
rs1247415711	1785	dbSNP
rs1312327273	1785	dbSNP
rs1451430987	1785	dbSNP
rs764817136	1785	dbSNP
rs769470085	1785	dbSNP
rs928088879	1785	dbSNP
rs1326600533	1786	dbSNP
rs1380246541	1787	dbSNP
rs765999023	1787	dbSNP
rs916654204	1789	dbSNP
rs991333516	1789	dbSNP
rs1001778671	1791	dbSNP
rs1161808616	1791	dbSNP
rs1426550500	1791	dbSNP
rs946740138	1791	dbSNP
rs1043704165	1793	dbSNP
rs192838192	1793	dbSNP
rs904453348	1793	dbSNP
rs1404777915	1794	dbSNP
rs397760648	1794	dbSNP
rs62015201	1795	dbSNP
rs1013892293	1796	dbSNP
rs1474572492	1796	dbSNP
rs557755181	1797	dbSNP
rs1200534975	1798	dbSNP
rs1267305769	1799	dbSNP
rs573120912	1799	dbSNP
rs1315188663	1801	dbSNP
rs540755469	1801	dbSNP
rs1216071759	1802	dbSNP
rs1193688884	1803	dbSNP
rs1225044936	1804	dbSNP
rs1283555077	1804	dbSNP
rs200380389	1804	dbSNP
rs1442915918	1805	dbSNP
rs967177831	1807	dbSNP
rs184783192	1808	dbSNP
rs1331031294	1813	dbSNP
rs1408298227	1813	dbSNP
rs149412059	1819	dbSNP
rs1177427147	1821	dbSNP
rs1246457736	1829	dbSNP
rs1470743147	1835	dbSNP
rs1052899400	1836	dbSNP
rs1179445962	1836	dbSNP
rs1234097485	1838	dbSNP
rs1406506774	1839	dbSNP
rs1416723025	1842	dbSNP
rs1456956956	1844	dbSNP
rs1157544348	1845	dbSNP
rs1365763108	1850	dbSNP
rs531438521	1851	dbSNP
rs1321138246	1852	dbSNP
rs890264247	1852	dbSNP
rs1008714496	1854	dbSNP
rs953189441	1858	dbSNP
rs559138891	1859	dbSNP
rs775828656	1859	dbSNP
rs1281209758	1863	dbSNP
rs1376271587	1864	dbSNP
rs1371102674	1866	dbSNP
rs867996805	1870	dbSNP
rs1239452438	1877	dbSNP
rs1471117278	1881	dbSNP
rs1404326222	1882	dbSNP
rs900242883	1889	dbSNP
rs189437506	1892	dbSNP
rs1027289271	1893	dbSNP
rs944034668	1894	dbSNP
rs1459739606	1899	dbSNP
rs533287224	1899	dbSNP
rs950957707	1900	dbSNP
rs1216188059	1904	dbSNP
rs976757663	1906	dbSNP
rs201443692	1908	dbSNP
rs983679449	1908	dbSNP
rs565161846	1912	dbSNP
rs961186957	1912	dbSNP
rs144725916	1913	dbSNP
rs1377193815	1914	dbSNP
rs1302521661	1923	dbSNP
rs865773795	1924	dbSNP
rs552904038	1925	dbSNP
rs755988587	1930	dbSNP
rs1048951852	1932	dbSNP
rs934599062	1934	dbSNP
rs888615811	1940	dbSNP
rs890365931	1941	dbSNP
rs937474337	1945	dbSNP
rs1055983370	1948	dbSNP
rs527268513	1949	dbSNP
rs181830706	1952	dbSNP
rs1486718231	1961	dbSNP
rs1410260721	1967	dbSNP
rs1330660648	1973	dbSNP
rs1038864272	1980	dbSNP
rs900256550	1988	dbSNP
rs1490507686	1995	dbSNP
rs1293893072	2010	dbSNP
rs560809564	2012	dbSNP
rs1337365316	2013	dbSNP
rs1312259134	2015	dbSNP
rs1215444534	2016	dbSNP
rs1364480703	2017	dbSNP
rs761739810	2021	dbSNP
rs531267736	2025	dbSNP
rs1048777478	2026	dbSNP
rs886128971	2027	dbSNP
rs1019976976	2028	dbSNP
rs1004536215	2030	dbSNP
rs779826025	2036	dbSNP
rs902840511	2043	dbSNP
rs1192611281	2045	dbSNP
rs1270879389	2047	dbSNP
rs1220183732	2048	dbSNP
rs1340336343	2050	dbSNP
rs1264975871	2052	dbSNP
rs1487542263	2052	dbSNP
rs960983918	2056	dbSNP
rs1012830203	2057	dbSNP
rs1054704	2060	dbSNP
rs1216644267	2061	dbSNP
rs1023772401	2064	dbSNP
rs367905903	2065	dbSNP
rs1389351523	2067	dbSNP
rs569083871	2073	dbSNP
rs539763008	2074	dbSNP
rs953201510	2076	dbSNP
rs1294651661	2078	dbSNP
rs956733432	2087	dbSNP
rs985934912	2087	dbSNP
rs1245579648	2099	dbSNP
rs986810853	2101	dbSNP
rs1470074858	2105	dbSNP
rs911837782	2116	dbSNP
rs551772920	2117	dbSNP
rs868449463	2119	dbSNP
rs1432566288	2126	dbSNP
rs1251179450	2128	dbSNP
rs750165866	2128	dbSNP
rs1184787561	2129	dbSNP
rs1177810431	2130	dbSNP
rs1481661338	2131	dbSNP
rs944601146	2131	dbSNP
rs1393108986	2142	dbSNP
rs1039290781	2145	dbSNP
rs1198314902	2148	dbSNP
rs1324713614	2149	dbSNP
rs566886529	2152	dbSNP
rs758074588	2153	dbSNP
rs1231681591	2155	dbSNP
rs921762995	2164	dbSNP
rs930444784	2172	dbSNP
rs75079637	2173	dbSNP
rs141905184	2175	dbSNP
rs1464960636	2176	dbSNP
rs1004588697	2194	dbSNP
rs1408215351	2199	dbSNP
rs1465382946	2201	dbSNP
rs918632171	2203	dbSNP
rs1333620914	2204	dbSNP
rs929925458	2207	dbSNP
rs984228633	2208	dbSNP
rs909940285	2212	dbSNP
rs75093650	2222	dbSNP
rs1236503270	2223	dbSNP
rs751191260	2224	dbSNP
rs1433119452	2225	dbSNP
rs1178226236	2231	dbSNP
rs1268689042	2234	dbSNP
rs547326877	2238	dbSNP
rs896740064	2239	dbSNP
rs1245226907	2242	dbSNP
rs1199054076	2249	dbSNP
rs1344760267	2249	dbSNP
rs1055911674	2251	dbSNP
rs895974804	2255	dbSNP
rs1012473823	2262	dbSNP
rs1307955269	2266	dbSNP
rs1452754917	2266	dbSNP
rs1340289139	2272	dbSNP
rs1331794877	2276	dbSNP
rs1024244319	2291	dbSNP
rs1385475173	2297	dbSNP
rs1224583478	2301	dbSNP
rs1417830898	2308	dbSNP
rs1378527878	2310	dbSNP
rs1158075914	2312	dbSNP
rs1445351705	2318	dbSNP
rs1265475659	2321	dbSNP
rs1322054706	2331	dbSNP
rs538313710	2344	dbSNP
rs1042359733	2347	dbSNP
rs1277252833	2354	dbSNP
rs1487563880	2360	dbSNP
rs902851373	2361	dbSNP
rs114123009	2365	dbSNP
rs1360989375	2366	dbSNP
rs1282049652	2369	dbSNP
rs1243700117	2370	dbSNP
rs867726785	2371	dbSNP
rs1326772929	2372	dbSNP

- Genes & development, 2013

When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.