pre-miRNA Information | |
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pre-miRNA | hsa-mir-1185-1 |
Genomic Coordinates | chr14: 101042977 - 101043062 |
Synonyms | MIRN1185-1, hsa-mir-1185-1, MIR1185-1 |
Description | Homo sapiens miR-1185-1 stem-loop |
Comment | This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-1185-1-3p | ||||||||||||||||||||||||||||||
Sequence | 53| AUAUACAGGGGGAGACUCUUAU |74 | ||||||||||||||||||||||||||||||
Evidence | Not_experimental | ||||||||||||||||||||||||||||||
Experiments | |||||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |
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Gene Symbol | KIAA2018 |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293S | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb
... - Karginov FV; Hannon GJ, 2013, Genes & development. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Karginov FV; Hannon GJ - Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
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CLIP-seq Support 1 for dataset GSM1084065 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_emetine_AbnovaAb |
Location of target site | ENST00000316407.4 | 3UTR | UGAAGAGAAGGAUUGUGUGUGUGUGUCU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT066415 | TBK1 | TANK binding kinase 1 | ![]() |
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2 | 4 | ||||||
MIRT073567 | NR2F2 | nuclear receptor subfamily 2 group F member 2 | ![]() |
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2 | 2 | ||||||
MIRT074516 | USP1 | ubiquitin specific peptidase 1 | ![]() |
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2 | 4 | ||||||
MIRT080576 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | ![]() |
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2 | 6 | ||||||
MIRT086539 | HSPE1-MOB4 | HSPE1-MOB4 readthrough | ![]() |
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2 | 2 | ||||||
MIRT086547 | MOB4 | MOB family member 4, phocein | ![]() |
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2 | 2 | ||||||
MIRT088684 | EML4 | echinoderm microtubule associated protein like 4 | ![]() |
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2 | 4 | ||||||
MIRT090811 | MBNL1 | muscleblind like splicing regulator 1 | ![]() |
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2 | 4 | ||||||
MIRT095500 | PURA | purine rich element binding protein A | ![]() |
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2 | 2 | ||||||
MIRT109530 | KLHL15 | kelch like family member 15 | ![]() |
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2 | 6 | ||||||
MIRT109807 | ZFX | zinc finger protein, X-linked | ![]() |
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2 | 2 | ||||||
MIRT117888 | ZBTB7A | zinc finger and BTB domain containing 7A | ![]() |
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2 | 2 | ||||||
MIRT120273 | GSK3B | glycogen synthase kinase 3 beta | ![]() |
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2 | 4 | ||||||
MIRT149892 | LDLR | low density lipoprotein receptor | ![]() |
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2 | 2 | ||||||
MIRT178475 | LCOR | ligand dependent nuclear receptor corepressor | ![]() |
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2 | 4 | ||||||
MIRT193445 | RORA | RAR related orphan receptor A | ![]() |
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2 | 2 | ||||||
MIRT198527 | DSG2 | desmoglein 2 | ![]() |
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2 | 2 | ||||||
MIRT226427 | TP53INP1 | tumor protein p53 inducible nuclear protein 1 | ![]() |
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2 | 2 | ||||||
MIRT227669 | SET | SET nuclear proto-oncogene | ![]() |
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2 | 2 | ||||||
MIRT320405 | HOXA9 | homeobox A9 | ![]() |
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2 | 2 | ||||||
MIRT407774 | MRPL35 | mitochondrial ribosomal protein L35 | ![]() |
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2 | 2 | ||||||
MIRT439228 | ZMIZ1 | zinc finger MIZ-type containing 1 | ![]() |
1 | 1 | |||||||
MIRT439312 | VAT1L | vesicle amine transport 1 like | ![]() |
1 | 1 | |||||||
MIRT439421 | TMOD1 | tropomodulin 1 | ![]() |
1 | 1 | |||||||
MIRT439446 | TMEM104 | transmembrane protein 104 | ![]() |
1 | 1 | |||||||
MIRT439524 | STIM2 | stromal interaction molecule 2 | ![]() |
1 | 1 | |||||||
MIRT439612 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) | ![]() |
1 | 1 | |||||||
MIRT439997 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | ![]() |
1 | 1 | |||||||
MIRT440017 | PCSK1 | proprotein convertase subtilisin/kexin type 1 | ![]() |
1 | 1 | |||||||
MIRT440131 | NCOA4 | nuclear receptor coactivator 4 | ![]() |
1 | 1 | |||||||
MIRT440311 | LRRC1 | leucine rich repeat containing 1 | ![]() |
1 | 1 | |||||||
MIRT440475 | IAPP | islet amyloid polypeptide | ![]() |
1 | 1 | |||||||
MIRT440511 | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | ![]() |
1 | 1 | |||||||
MIRT440617 | FOXA2 | forkhead box A2 | ![]() |
1 | 1 | |||||||
MIRT440666 | FBXL16 | F-box and leucine rich repeat protein 16 | ![]() |
1 | 1 | |||||||
MIRT440705 | ERO1LB | endoplasmic reticulum oxidoreductase 1 beta | ![]() |
1 | 1 | |||||||
MIRT441007 | CAPZA2 | capping actin protein of muscle Z-line alpha subunit 2 | ![]() |
1 | 1 | |||||||
MIRT441018 | CAND1 | cullin associated and neddylation dissociated 1 | ![]() |
1 | 1 | |||||||
MIRT441062 | C1orf43 | chromosome 1 open reading frame 43 | ![]() |
1 | 1 | |||||||
MIRT441209 | ARCN1 | archain 1 | ![]() |
1 | 1 | |||||||
MIRT449461 | HAT1 | histone acetyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT467104 | SRI | sorcin | ![]() |
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2 | 2 | ||||||
MIRT468060 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | ![]() |
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2 | 10 | ||||||
MIRT468476 | SESN3 | sestrin 3 | ![]() |
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2 | 4 | ||||||
MIRT473533 | MAX | MYC associated factor X | ![]() |
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2 | 2 | ||||||
MIRT473852 | MAP2K4 | mitogen-activated protein kinase kinase 4 | ![]() |
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2 | 2 | ||||||
MIRT474711 | KIF13A | kinesin family member 13A | ![]() |
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2 | 6 | ||||||
MIRT481665 | ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | ![]() |
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2 | 2 | ||||||
MIRT485120 | SF3B3 | splicing factor 3b subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT493055 | MTFR1 | mitochondrial fission regulator 1 | ![]() |
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2 | 2 | ||||||
MIRT504258 | C1orf147 | chromosome 1 open reading frame 147 | ![]() |
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2 | 4 | ||||||
MIRT504361 | ARID1B | AT-rich interaction domain 1B | ![]() |
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2 | 4 | ||||||
MIRT505748 | SENP1 | SUMO1/sentrin specific peptidase 1 | ![]() |
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2 | 8 | ||||||
MIRT506298 | PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | ![]() |
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2 | 6 | ||||||
MIRT508442 | ZNF608 | zinc finger protein 608 | ![]() |
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2 | 4 | ||||||
MIRT512782 | COL4A3BP | collagen type IV alpha 3 binding protein | ![]() |
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2 | 2 | ||||||
MIRT520447 | TSPAN2 | tetraspanin 2 | ![]() |
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2 | 4 | ||||||
MIRT522133 | NRBF2 | nuclear receptor binding factor 2 | ![]() |
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2 | 6 | ||||||
MIRT522395 | MYADM | myeloid associated differentiation marker | ![]() |
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2 | 4 | ||||||
MIRT523397 | GRIK3 | glutamate ionotropic receptor kainate type subunit 3 | ![]() |
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2 | 4 | ||||||
MIRT523938 | E2F8 | E2F transcription factor 8 | ![]() |
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2 | 4 | ||||||
MIRT524349 | CREB1 | cAMP responsive element binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT524711 | BRMS1L | breast cancer metastasis-suppressor 1 like | ![]() |
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2 | 4 | ||||||
MIRT525134 | ZNF256 | zinc finger protein 256 | ![]() |
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2 | 2 | ||||||
MIRT525710 | DCAF12L2 | DDB1 and CUL4 associated factor 12 like 2 | ![]() |
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2 | 2 | ||||||
MIRT531264 | PPIL3 | peptidylprolyl isomerase like 3 | ![]() |
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2 | 2 | ||||||
MIRT538844 | BTG1 | BTG anti-proliferation factor 1 | ![]() |
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2 | 2 | ||||||
MIRT541366 | CDKN1B | cyclin dependent kinase inhibitor 1B | ![]() |
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2 | 2 | ||||||
MIRT542093 | KCNK10 | potassium two pore domain channel subfamily K member 10 | ![]() |
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2 | 6 | ||||||
MIRT543770 | RBM12B | RNA binding motif protein 12B | ![]() |
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2 | 4 | ||||||
MIRT543940 | NCOA7 | nuclear receptor coactivator 7 | ![]() |
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2 | 2 | ||||||
MIRT545150 | GABRG1 | gamma-aminobutyric acid type A receptor gamma1 subunit | ![]() |
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2 | 2 | ||||||
MIRT545842 | ZNF264 | zinc finger protein 264 | ![]() |
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2 | 4 | ||||||
MIRT548057 | GOLGA7 | golgin A7 | ![]() |
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2 | 2 | ||||||
MIRT549242 | ATXN1L | ataxin 1 like | ![]() |
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2 | 4 | ||||||
MIRT551829 | AASDHPPT | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | ![]() |
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2 | 2 | ||||||
MIRT552484 | ZNF136 | zinc finger protein 136 | ![]() |
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2 | 2 | ||||||
MIRT553663 | TGFBR2 | transforming growth factor beta receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT554988 | RAB39B | RAB39B, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT555760 | PCTP | phosphatidylcholine transfer protein | ![]() |
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2 | 2 | ||||||
MIRT556923 | IRF2BP2 | interferon regulatory factor 2 binding protein 2 | ![]() |
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2 | 4 | ||||||
MIRT564991 | WNK1 | WNK lysine deficient protein kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT566458 | PGGT1B | protein geranylgeranyltransferase type I subunit beta | ![]() |
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2 | 2 | ||||||
MIRT566538 | PANK3 | pantothenate kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT567732 | DLX2 | distal-less homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT570081 | KANSL1L | KAT8 regulatory NSL complex subunit 1 like | ![]() |
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2 | 2 | ||||||
MIRT571735 | RNF11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT573529 | MDM2 | MDM2 proto-oncogene | ![]() |
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2 | 2 | ||||||
MIRT574459 | RPS16 | ribosomal protein S16 | ![]() |
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2 | 2 | ||||||
MIRT574992 | Phka1 | phosphorylase kinase alpha 1 | ![]() |
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2 | 3 | ||||||
MIRT576349 | Pxdn | peroxidasin | ![]() |
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2 | 2 | ||||||
MIRT610196 | CD99 | CD99 molecule (Xg blood group) | ![]() |
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2 | 4 | ||||||
MIRT612920 | GPRIN3 | GPRIN family member 3 | ![]() |
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2 | 2 | ||||||
MIRT615021 | DUSP6 | dual specificity phosphatase 6 | ![]() |
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2 | 2 | ||||||
MIRT623573 | IRS1 | insulin receptor substrate 1 | ![]() |
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2 | 2 | ||||||
MIRT624437 | CASD1 | CAS1 domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT628714 | ZNF585A | zinc finger protein 585A | ![]() |
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2 | 2 | ||||||
MIRT639565 | PCK1 | phosphoenolpyruvate carboxykinase 1 | ![]() |
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2 | 4 | ||||||
MIRT641485 | POLA2 | DNA polymerase alpha 2, accessory subunit | ![]() |
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2 | 2 | ||||||
MIRT641657 | PAPOLG | poly(A) polymerase gamma | ![]() |
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2 | 2 | ||||||
MIRT642210 | RUVBL2 | RuvB like AAA ATPase 2 | ![]() |
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2 | 2 | ||||||
MIRT653010 | STX7 | syntaxin 7 | ![]() |
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2 | 2 | ||||||
MIRT656130 | MSH6 | mutS homolog 6 | ![]() |
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2 | 2 | ||||||
MIRT656893 | KIAA2018 | upstream transcription factor family member 3 | ![]() |
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2 | 2 | ||||||
MIRT660130 | BRPF3 | bromodomain and PHD finger containing 3 | ![]() |
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2 | 2 | ||||||
MIRT660855 | AFAP1 | actin filament associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT676843 | PHKA1 | phosphorylase kinase regulatory subunit alpha 1 | ![]() |
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2 | 3 | ||||||
MIRT681473 | DIP2A | disco interacting protein 2 homolog A | ![]() |
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2 | 2 | ||||||
MIRT682253 | RS1 | retinoschisin 1 | ![]() |
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2 | 2 | ||||||
MIRT694296 | COPB2 | coatomer protein complex subunit beta 2 | ![]() |
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2 | 2 | ||||||
MIRT694401 | ALDH1A3 | aldehyde dehydrogenase 1 family member A3 | ![]() |
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2 | 2 | ||||||
MIRT705277 | BACH1 | BTB domain and CNC homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT720833 | C1orf52 | chromosome 1 open reading frame 52 | ![]() |
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2 | 2 | ||||||
MIRT735713 | SIRT1 | sirtuin 1 | ![]() |
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2 | 0 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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