pre-miRNA Information
pre-miRNA hsa-mir-500b   
Genomic Coordinates chrX: 50010672 - 50010750
Description Homo sapiens miR-500b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-500b-3p
Sequence 51| GCACCCAGGCAAGGAUUCUG |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs782140253 8 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HNRNPK   
Synonyms AUKS, CSBP, HNRPK, TUNP
Description heterogeneous nuclear ribonucleoprotein K
Transcript NM_002140   
Other Transcripts NM_031262 , NM_031263   
Expression
Putative miRNA Targets on HNRNPK
3'UTR of HNRNPK
(miRNA target sites are highlighted)
>HNRNPK|NM_002140|3'UTR
   1 TGCAAGATATTTTTTCTTTTTTATAGTGTGAAGCAGTATTCTGGAAAGTTTTTCTAAGACTAGTGAAGAACTGAAGGAGT
  81 CCTGCATCTTTTTTTTTTTATCTGCTTCTGTTTAAAAAGCCAACATTCCTCTGCTTCATAGGTGTTCTGCATTTGAGGTG
 161 TAGTGAAATCTTTGCTGTTCACCAGATGTAATGTTTTAGTTCCTTACAAACAGGGTTGGGGGGGGGAAGGGCGTGCAAAA
 241 ACTAACATTGAAATTTTGAAACAGCAGCAGAGTGAGTGGATTTTATTTTTCGTTATTGTTGGTGGTTTAAAAAATTCCCC
 321 CCATGTAATTATTGTGAACACCTTGCTTTGTGGTCACTGTAACATTTGGGGGGTGGGACAGGGAGGAAAAGTAACAATAG
 401 TCCACATGTCCCTGGCATCTGTTCAGAGCAGTGTGCAGAATGTAATGCTCTTTTGTAAGAAACGTTTTATGATTTTTAAA
 481 ATAAATTTAGTGAACCTATTTTTGGTGGTCATTTTTTTTTTAAGACAGTCATTTTAAAATGGTGGCTGAATTTCCCAACC
 561 CACCCCCAAACTAAACACTAAGTTTAATTTTCAGCTCCTCTGTTGGACATATAAGTGCATCTCTTGTTGGACATAGGCAA
 641 AATAACTTGGCAAACTTAGTTCTGGTGATTTCTTGATGGTTTGGAAGTCTATTGCTGGGAAGAAATTCCATCATACATAT
 721 TCATGCTTATAATAAGCTGGGGATTTTTTGTTTGTTTTTGCAAATGCTTGCCCCTACTTTTCAACAATTTTCTATGTTAG
 801 TTGTGAAGAACTAAGGTGGGGAGCAGTACTACAAGTTGAGTAATGGTATGAGTATATACCAGAATTCTGATTGGCAGCAA
 881 GTTTTATTAATCAGAATAACACTTGGTTATGGAAGTGACTAATGCTGAAAAAATTGATTATTTTTATTAGATAATTTCTC
 961 ACCTATAGACTTAAACTGTCAATTTGCTCTAGTGTCTTATTAGTTAAACTTTGTAAAATATATATATACTTGTTTTTCCA
1041 TTGTATGCAAATTGAAAGAAAAAGATGTACCATTTCTCTGTTGTATGTTGGATTATGTAGGAAATGTTTGTGTACAATTC
1121 AAAAAAAAAAAAGATGAAAAAAGTTCCTGTGGATGTTTTGTGTAGTATCTTGGCATTTGTATTGATAGTTAAAATTCACT
1201 TCCAAATAAATAAAACACCCATGATGCTAGATTTGATGTGTGCCCGATTTGAACAAGGGTTGATTGACACCTGTAAAATT
1281 TGTTGAAACGTTCCTCTTAAAAGGAAATATAGTAATCTTATGTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' guCUU-AGG-AACGGACCCacg 5'
            ||| ||: ||| |||||   
Target 5' tgGAAGTCTATTG-CTGGGaag 3'
682 - 702 117.00 -11.42
2
miRNA  3' guCUUAGGAACGGACCCACg 5'
            ||| |||  ::| |||| 
Target 5' gtGAA-CCTATTTTTGGTGg 3'
490 - 508 109.00 -7.80
3
miRNA  3' gucuuAGGAACG---GACCCAcg 5'
               ||||| |   | ||||  
Target 5' ttagtTCCTTACAAACAGGGTtg 3'
196 - 218 103.00 -9.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30524334 8 COSMIC
COSN30495974 9 COSMIC
COSN30168938 11 COSMIC
COSN30482485 11 COSMIC
COSN30134909 16 COSMIC
COSM3220366 26 COSMIC
COSM9623468 32 COSMIC
COSM3848983 44 COSMIC
COSM9623464 45 COSMIC
COSM9623470 46 COSMIC
COSN30148475 65 COSMIC
COSN31499316 68 COSMIC
COSN26979124 74 COSMIC
COSN30537918 75 COSMIC
COSN19663095 89 COSMIC
COSN30513284 110 COSMIC
COSN26979121 144 COSMIC
COSN31569356 217 COSMIC
COSN18733501 218 COSMIC
COSN26642514 375 COSMIC
COSN26644707 391 COSMIC
COSN22120624 397 COSMIC
COSN22119065 405 COSMIC
COSN22512464 421 COSMIC
COSN17622324 592 COSMIC
COSN20921614 636 COSMIC
COSN31486080 748 COSMIC
COSN31543694 823 COSMIC
COSN31596669 825 COSMIC
COSN9286621 932 COSMIC
COSN24302840 1115 COSMIC
COSN26641472 1133 COSMIC
COSN26573656 1188 COSMIC
COSN31482174 1231 COSMIC
COSN19658175 1246 COSMIC
rs696825 1246 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769556649 7 dbSNP
rs1180978547 11 dbSNP
rs750510015 16 dbSNP
rs761640766 64 dbSNP
rs1393211334 66 dbSNP
rs775690176 74 dbSNP
rs1245395178 80 dbSNP
rs1204743462 84 dbSNP
rs770427896 85 dbSNP
rs772342106 86 dbSNP
rs1259498703 88 dbSNP
rs1218475192 89 dbSNP
rs1402095620 96 dbSNP
rs1411679750 98 dbSNP
rs778982610 99 dbSNP
rs1267590238 100 dbSNP
rs554180409 100 dbSNP
rs752597394 100 dbSNP
rs759311884 100 dbSNP
rs538741250 101 dbSNP
rs770942700 102 dbSNP
rs1431338828 104 dbSNP
rs1385227126 105 dbSNP
rs1315951790 108 dbSNP
rs1427930278 120 dbSNP
rs1358109134 122 dbSNP
rs1207704773 124 dbSNP
rs1266157945 127 dbSNP
rs970763193 128 dbSNP
rs1183664748 130 dbSNP
rs1249581593 139 dbSNP
rs1472212468 141 dbSNP
rs1165293367 143 dbSNP
rs746533799 147 dbSNP
rs993507409 148 dbSNP
rs1162909570 154 dbSNP
rs1397425679 158 dbSNP
rs11548848 162 dbSNP
rs899268198 163 dbSNP
rs11548841 165 dbSNP
rs1249010439 174 dbSNP
rs1195649692 175 dbSNP
rs1016344398 181 dbSNP
rs1315362674 187 dbSNP
rs376145578 191 dbSNP
rs772821065 193 dbSNP
rs1260236652 200 dbSNP
rs1221849097 202 dbSNP
rs1271846659 207 dbSNP
rs1482728213 215 dbSNP
rs1049675527 217 dbSNP
rs933936355 219 dbSNP
rs544139763 220 dbSNP
rs370696476 221 dbSNP
rs945049318 222 dbSNP
rs1395626939 225 dbSNP
rs1296586331 226 dbSNP
rs1295209773 227 dbSNP
rs369234036 227 dbSNP
rs543934551 227 dbSNP
rs767325681 227 dbSNP
rs576710148 232 dbSNP
rs989168740 233 dbSNP
rs938185856 238 dbSNP
rs1257206977 240 dbSNP
rs1482004077 247 dbSNP
rs747870638 248 dbSNP
rs1248267455 256 dbSNP
rs926761531 271 dbSNP
rs1187053248 281 dbSNP
rs1389999553 286 dbSNP
rs1434228966 290 dbSNP
rs14961 291 dbSNP
rs574844183 292 dbSNP
rs1465617384 294 dbSNP
rs1332974752 295 dbSNP
rs7033844 296 dbSNP
rs1391098453 298 dbSNP
rs149773802 299 dbSNP
rs1172702285 302 dbSNP
rs972500980 304 dbSNP
rs140560283 315 dbSNP
rs1016375752 323 dbSNP
rs1231888115 323 dbSNP
rs1309865049 323 dbSNP
rs1206479723 332 dbSNP
rs1055950 340 dbSNP
rs555056353 342 dbSNP
rs953866891 346 dbSNP
rs3196513 356 dbSNP
rs1193368281 361 dbSNP
rs1423689205 361 dbSNP
rs758071552 363 dbSNP
rs998012645 366 dbSNP
rs1158739275 369 dbSNP
rs1440715732 369 dbSNP
rs536302815 370 dbSNP
rs1436940048 371 dbSNP
rs901114995 372 dbSNP
rs1240364807 375 dbSNP
rs1202046447 377 dbSNP
rs569520360 378 dbSNP
rs1263966174 379 dbSNP
rs551187765 383 dbSNP
rs1288395929 385 dbSNP
rs1330643825 388 dbSNP
rs1226137562 393 dbSNP
rs1009667325 395 dbSNP
rs1322630259 396 dbSNP
rs532893283 397 dbSNP
rs571950932 398 dbSNP
rs1224229235 402 dbSNP
rs893435899 406 dbSNP
rs1488425889 407 dbSNP
rs1348546543 408 dbSNP
rs1254014774 410 dbSNP
rs1471661228 411 dbSNP
rs1053477749 419 dbSNP
rs1414797244 424 dbSNP
rs187791877 438 dbSNP
rs926369624 439 dbSNP
rs1047022109 447 dbSNP
rs949564710 453 dbSNP
rs1308583494 461 dbSNP
rs1311232202 462 dbSNP
rs1278509446 463 dbSNP
rs1407459111 463 dbSNP
rs754821056 464 dbSNP
rs919515054 466 dbSNP
rs1359209267 467 dbSNP
rs972318000 470 dbSNP
rs1277406985 479 dbSNP
rs1404970985 487 dbSNP
rs1334392257 488 dbSNP
rs963711887 489 dbSNP
rs1473880988 490 dbSNP
rs1489003173 491 dbSNP
rs1180368351 495 dbSNP
rs1411297501 496 dbSNP
rs1443792596 497 dbSNP
rs1415690992 498 dbSNP
rs909178481 499 dbSNP
rs1427802820 504 dbSNP
rs527287924 511 dbSNP
rs1359272637 512 dbSNP
rs1449711754 518 dbSNP
rs1282085941 521 dbSNP
rs953465495 522 dbSNP
rs986128498 522 dbSNP
rs1030409524 525 dbSNP
rs998440705 526 dbSNP
rs1195773171 528 dbSNP
rs1420801836 532 dbSNP
rs1279373748 536 dbSNP
rs1444222693 539 dbSNP
rs1382672205 547 dbSNP
rs1208553568 549 dbSNP
rs1237123902 557 dbSNP
rs542039401 558 dbSNP
rs1465566286 568 dbSNP
rs749188256 569 dbSNP
rs965219375 571 dbSNP
rs1447544150 576 dbSNP
rs1167291239 577 dbSNP
rs1182185809 579 dbSNP
rs1021295190 580 dbSNP
rs1415691000 580 dbSNP
rs1331708386 581 dbSNP
rs1435426003 582 dbSNP
rs1444386208 582 dbSNP
rs1009455022 588 dbSNP
rs893718990 593 dbSNP
rs1053421856 594 dbSNP
rs1001804673 595 dbSNP
rs572952414 597 dbSNP
rs904978774 600 dbSNP
rs1189807542 602 dbSNP
rs1046117690 604 dbSNP
rs1330056483 611 dbSNP
rs559846334 612 dbSNP
rs1249617187 623 dbSNP
rs1445085692 625 dbSNP
rs919392146 626 dbSNP
rs35668472 628 dbSNP
rs1479002500 629 dbSNP
rs942293176 633 dbSNP
rs909446587 640 dbSNP
rs541953651 642 dbSNP
rs1386837129 651 dbSNP
rs931941838 652 dbSNP
rs779874973 653 dbSNP
rs1435007510 662 dbSNP
rs757317371 663 dbSNP
rs1288056138 672 dbSNP
rs1243580074 682 dbSNP
rs751560330 687 dbSNP
rs182623942 691 dbSNP
rs1453224688 693 dbSNP
rs1284443428 707 dbSNP
rs1449708838 710 dbSNP
rs1324207739 720 dbSNP
rs1317074416 723 dbSNP
rs562376322 730 dbSNP
rs957969434 736 dbSNP
rs988378898 736 dbSNP
rs1363071731 737 dbSNP
rs1409306395 737 dbSNP
rs1164176123 741 dbSNP
rs1393376326 750 dbSNP
rs1404052471 750 dbSNP
rs1303098624 753 dbSNP
rs11548852 754 dbSNP
rs1032204839 755 dbSNP
rs1411741860 755 dbSNP
rs552890247 758 dbSNP
rs904844500 763 dbSNP
rs1284531734 772 dbSNP
rs764206626 784 dbSNP
rs1424436531 789 dbSNP
rs1290953762 791 dbSNP
rs7884 792 dbSNP
rs1414913237 794 dbSNP
rs1165250339 796 dbSNP
rs543981021 797 dbSNP
rs757853197 803 dbSNP
rs1418118166 805 dbSNP
rs1187850704 808 dbSNP
rs1241718868 811 dbSNP
rs1025145949 814 dbSNP
rs1013302491 815 dbSNP
rs1371704048 820 dbSNP
rs1432227736 822 dbSNP
rs576600467 824 dbSNP
rs758605506 827 dbSNP
rs1265246049 829 dbSNP
rs756206866 833 dbSNP
rs1395903702 834 dbSNP
rs558830143 840 dbSNP
rs1396777049 844 dbSNP
rs1036557252 847 dbSNP
rs1220091613 854 dbSNP
rs540115160 855 dbSNP
rs771072245 856 dbSNP
rs888043496 867 dbSNP
rs1230568811 871 dbSNP
rs1249068231 872 dbSNP
rs573195181 889 dbSNP
rs1200617834 892 dbSNP
rs1257840417 894 dbSNP
rs1459748977 897 dbSNP
rs931974404 901 dbSNP
rs554663508 904 dbSNP
rs976483605 906 dbSNP
rs1168983296 909 dbSNP
rs1372517868 909 dbSNP
rs1480373532 917 dbSNP
rs752983193 921 dbSNP
rs765528559 924 dbSNP
rs200285431 925 dbSNP
rs759917704 934 dbSNP
rs1452249417 939 dbSNP
rs1335803657 940 dbSNP
rs1365699516 940 dbSNP
rs913286845 947 dbSNP
rs1293362584 948 dbSNP
rs1233327224 949 dbSNP
rs987960789 949 dbSNP
rs957837132 953 dbSNP
rs1337097141 954 dbSNP
rs1320938881 958 dbSNP
rs777157585 962 dbSNP
rs1248983407 963 dbSNP
rs1466540583 965 dbSNP
rs373101755 969 dbSNP
rs969033876 973 dbSNP
rs1434310684 974 dbSNP
rs1178297300 978 dbSNP
rs766767358 982 dbSNP
rs1286136792 983 dbSNP
rs1469446879 989 dbSNP
rs1013666550 991 dbSNP
rs1301862644 999 dbSNP
rs189989209 1000 dbSNP
rs373425095 1007 dbSNP
rs1326002603 1009 dbSNP
rs1361162548 1012 dbSNP
rs1015059208 1017 dbSNP
rs1006414435 1019 dbSNP
rs1222461107 1021 dbSNP
rs1268375786 1022 dbSNP
rs887907490 1026 dbSNP
rs147225092 1027 dbSNP
rs1478848955 1029 dbSNP
rs1427236167 1033 dbSNP
rs1489074171 1040 dbSNP
rs932257381 1041 dbSNP
rs1266800432 1046 dbSNP
rs902093147 1052 dbSNP
rs1040401451 1058 dbSNP
rs1414457244 1061 dbSNP
rs946023888 1067 dbSNP
rs767463277 1068 dbSNP
rs1156632038 1069 dbSNP
rs1247195870 1071 dbSNP
rs1223571664 1079 dbSNP
rs1344425423 1084 dbSNP
rs913326604 1085 dbSNP
rs1054445219 1095 dbSNP
rs1304895167 1103 dbSNP
rs936509449 1105 dbSNP
rs1403797475 1106 dbSNP
rs1288496397 1110 dbSNP
rs1375038981 1111 dbSNP
rs1221752718 1114 dbSNP
rs1435864186 1115 dbSNP
rs925082307 1117 dbSNP
rs1218799999 1118 dbSNP
rs1319426416 1119 dbSNP
rs78890182 1120 dbSNP
rs75678734 1121 dbSNP
rs1218105864 1126 dbSNP
rs1290216661 1131 dbSNP
rs1490348173 1132 dbSNP
rs1205938288 1133 dbSNP
rs879181327 1133 dbSNP
rs917814457 1133 dbSNP
rs980564234 1133 dbSNP
rs991852348 1135 dbSNP
rs961991561 1137 dbSNP
rs1363626183 1138 dbSNP
rs1423994731 1148 dbSNP
rs1308079958 1149 dbSNP
rs1014685584 1153 dbSNP
rs557619812 1154 dbSNP
rs1169967186 1159 dbSNP
rs1277113815 1160 dbSNP
rs1380261112 1166 dbSNP
rs539260781 1168 dbSNP
rs571826814 1171 dbSNP
rs1332330250 1177 dbSNP
rs772587185 1181 dbSNP
rs1276809079 1188 dbSNP
rs771779532 1194 dbSNP
rs1029206576 1196 dbSNP
rs1467345029 1200 dbSNP
rs1204012405 1204 dbSNP
rs1404146802 1206 dbSNP
rs1238265141 1210 dbSNP
rs996329055 1212 dbSNP
rs1433832505 1215 dbSNP
rs1383195181 1221 dbSNP
rs1443885197 1222 dbSNP
rs1425872427 1229 dbSNP
rs1169166322 1233 dbSNP
rs1420954000 1235 dbSNP
rs1407714684 1238 dbSNP
rs1169212584 1240 dbSNP
rs1192782196 1245 dbSNP
rs696825 1246 dbSNP
rs535002918 1249 dbSNP
rs1382531754 1250 dbSNP
rs1237297449 1259 dbSNP
rs1338090170 1266 dbSNP
rs1214050761 1270 dbSNP
rs1279484913 1271 dbSNP
rs1325890785 1271 dbSNP
rs1202041116 1273 dbSNP
rs1240985476 1274 dbSNP
rs1199006428 1278 dbSNP
rs1460714671 1280 dbSNP
rs566501427 1282 dbSNP
rs1010254957 1287 dbSNP
rs576434433 1288 dbSNP
rs547859514 1289 dbSNP
rs11140311 1290 dbSNP
rs1425307648 1293 dbSNP
rs1312192664 1296 dbSNP
rs1470724988 1304 dbSNP
rs1173833884 1309 dbSNP
rs1304062228 1310 dbSNP
rs1458091275 1314 dbSNP
rs1320757935 1315 dbSNP
rs936120462 1317 dbSNP
rs1275468804 1318 dbSNP
rs1430696211 1318 dbSNP
rs878919287 1321 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gucuuaggaacGGACCCACg 5'
                     ::|||||| 
Target 5' -----------UUUGGGUGa 3'
1 - 9
2
miRNA  3' guCUUAG----GAACGGACCCACg 5'
            ||||:    |  | :|||| | 
Target 5' gaGAAUUGGGAC-AGGUUGGGAGa 3'
8 - 30
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000376281.4 | 3UTR | UUUGGGUGAGAAUUGGGACAGGUUGGGAGAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
172 hsa-miR-500b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059905 HDGF heparin binding growth factor 2 4
MIRT235394 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 4
MIRT442246 PYGO1 pygopus family PHD finger 1 2 2
MIRT443591 ZNF439 zinc finger protein 439 2 4
MIRT453280 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT463540 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT465589 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT469462 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT485449 KCTD15 potassium channel tetramerization domain containing 15 2 4
MIRT486682 WDR81 WD repeat domain 81 2 2
MIRT489078 POLM DNA polymerase mu 2 2
MIRT493734 GREM2 gremlin 2, DAN family BMP antagonist 2 2
MIRT494872 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT496130 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT496489 CHMP3 charged multivesicular body protein 3 2 2
MIRT496924 CLMN calmin 2 2
MIRT497297 TMEM119 transmembrane protein 119 2 2
MIRT499103 AGRN agrin 2 2
MIRT508979 CXorf38 chromosome X open reading frame 38 2 2
MIRT509911 NIPAL1 NIPA like domain containing 1 2 2
MIRT512820 ARRDC2 arrestin domain containing 2 2 4
MIRT512827 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT515360 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT516610 TRIM58 tripartite motif containing 58 2 2
MIRT517053 TLDC1 TBC/LysM-associated domain containing 1 2 2
MIRT517637 ZNF491 zinc finger protein 491 2 2
MIRT518270 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT518625 STAR steroidogenic acute regulatory protein 2 2
MIRT518887 N4BP2L2 NEDD4 binding protein 2 like 2 2 2
MIRT519026 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT520365 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT521106 SLC1A5 solute carrier family 1 member 5 2 2
MIRT521943 PHC3 polyhomeotic homolog 3 2 2
MIRT522253 NPEPPS aminopeptidase puromycin sensitive 2 2
MIRT522853 KIAA1551 KIAA1551 2 2
MIRT522868 KIAA1549 KIAA1549 2 2
MIRT524207 DDX19B DEAD-box helicase 19B 2 2
MIRT526004 ARHGAP27 Rho GTPase activating protein 27 2 2
MIRT527769 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT527827 TMEM74B transmembrane protein 74B 2 2
MIRT527861 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT528040 WT1 Wilms tumor 1 2 2
MIRT529802 ZDHHC8 zinc finger DHHC-type containing 8 2 2
MIRT531723 TARS threonyl-tRNA synthetase 2 2
MIRT531996 BARD1 BRCA1 associated RING domain 1 2 2
MIRT533338 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT533621 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT533652 TMOD2 tropomodulin 2 2 2
MIRT534397 SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 2 2
MIRT538686 CCDC80 coiled-coil domain containing 80 2 2
MIRT540444 RBM43 RNA binding motif protein 43 2 2
MIRT542586 ZC3H12C zinc finger CCCH-type containing 12C 2 8
MIRT542796 PLEKHA3 pleckstrin homology domain containing A3 2 4
MIRT542991 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT544424 ZNF460 zinc finger protein 460 2 4
MIRT545740 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 4
MIRT552618 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT554456 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT569663 PRIM1 DNA primase subunit 1 2 2
MIRT569924 PCSK9 proprotein convertase subtilisin/kexin type 9 2 2
MIRT570140 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT573558 TMEM120B transmembrane protein 120B 2 2
MIRT574282 OPRD1 opioid receptor delta 1 2 2
MIRT575335 Fbxo6 F-box protein 6 2 2
MIRT607057 IDS iduronate 2-sulfatase 2 2
MIRT607078 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607500 HEBP2 heme binding protein 2 2 2
MIRT607530 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT607808 RHBDL2 rhomboid like 2 2 2
MIRT608079 ZFP14 ZFP14 zinc finger protein 2 2
MIRT609119 NUDT3 nudix hydrolase 3 2 2
MIRT609745 PTCH1 patched 1 2 2
MIRT612904 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 2
MIRT618720 PCSK2 proprotein convertase subtilisin/kexin type 2 2 2
MIRT618778 HLA-E major histocompatibility complex, class I, E 2 2
MIRT619015 SLC2A6 solute carrier family 2 member 6 2 2
MIRT623223 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT623819 GEMIN6 gem nuclear organelle associated protein 6 2 2
MIRT625704 OPTN optineurin 2 2
MIRT626437 CHDH choline dehydrogenase 2 2
MIRT628087 KAT7 lysine acetyltransferase 7 2 2
MIRT628936 APOB apolipoprotein B 2 2
MIRT633543 PGBD5 piggyBac transposable element derived 5 2 2
MIRT634348 SGOL1 shugoshin 1 2 2
MIRT634611 KIAA1919 major facilitator superfamily domain containing 4B 2 2
MIRT635243 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT636681 BTLA B and T lymphocyte associated 2 2
MIRT636923 ZNF845 zinc finger protein 845 2 2
MIRT637606 ZNF554 zinc finger protein 554 2 2
MIRT639242 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT640835 POLR3A RNA polymerase III subunit A 2 2
MIRT642098 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT643087 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT643934 C17orf104 meiosis specific with coiled-coil domain 2 2
MIRT644353 FXN frataxin 2 2
MIRT645628 SF3A3 splicing factor 3a subunit 3 2 2
MIRT645754 FAM213A family with sequence similarity 213 member A 2 2
MIRT646329 MVB12B multivesicular body subunit 12B 2 2
MIRT646817 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT647019 ADCY2 adenylate cyclase 2 2 2
MIRT647621 IGSF9B immunoglobulin superfamily member 9B 2 2
MIRT648517 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT648871 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT649620 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650062 CCDC134 coiled-coil domain containing 134 2 2
MIRT650734 TNFSF8 TNF superfamily member 8 2 2
MIRT652389 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT654352 RBM27 RNA binding motif protein 27 2 2
MIRT655796 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT657329 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT657734 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT660613 ANO6 anoctamin 6 2 2
MIRT661243 ARL17B ADP ribosylation factor like GTPase 17B 2 2
MIRT662245 PGBD4 piggyBac transposable element derived 4 2 2
MIRT662921 MED18 mediator complex subunit 18 2 2
MIRT662963 JPH2 junctophilin 2 2 2
MIRT663347 ZNF74 zinc finger protein 74 2 2
MIRT663528 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663547 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663977 ZNF786 zinc finger protein 786 2 2
MIRT664084 METTL2B methyltransferase like 2B 2 2
MIRT664358 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664421 TIGD6 tigger transposable element derived 6 2 2
MIRT664476 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT664979 TDRD1 tudor domain containing 1 2 2
MIRT665128 PYCRL pyrroline-5-carboxylate reductase 3 2 2
MIRT666259 SLC31A1 solute carrier family 31 member 1 2 2
MIRT666321 SLC16A10 solute carrier family 16 member 10 2 2
MIRT666881 POLQ DNA polymerase theta 2 2
MIRT668469 FADS6 fatty acid desaturase 6 2 2
MIRT669554 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT669835 ISCA2 iron-sulfur cluster assembly 2 2 2
MIRT670185 CCDC142 coiled-coil domain containing 142 2 2
MIRT672020 PXMP4 peroxisomal membrane protein 4 2 2
MIRT672070 KIAA0930 KIAA0930 2 2
MIRT672475 RTTN rotatin 2 2
MIRT672851 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT673090 AK1 adenylate kinase 1 2 2
MIRT673581 KDELC2 KDEL motif containing 2 2 2
MIRT674586 SLC35B4 solute carrier family 35 member B4 2 2
MIRT675001 STRN3 striatin 3 2 2
MIRT679018 MTMR10 myotubularin related protein 10 2 2
MIRT679680 STAT3 signal transducer and activator of transcription 3 2 2
MIRT682833 FLG2 filaggrin family member 2 2 2
MIRT682886 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT683442 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 2
MIRT687040 RNF115 ring finger protein 115 2 2
MIRT691957 RHOH ras homolog family member H 2 2
MIRT694625 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695637 SLC26A2 solute carrier family 26 member 2 2 2
MIRT697640 WRN Werner syndrome RecQ like helicase 2 2
MIRT702009 MIDN midnolin 2 2
MIRT702034 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT704789 CDK6 cyclin dependent kinase 6 2 2
MIRT705728 AMMECR1L AMMECR1 like 2 2
MIRT705879 ADM adrenomedullin 2 2
MIRT706220 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT708418 CERS4 ceramide synthase 4 2 2
MIRT709114 C3orf18 chromosome 3 open reading frame 18 2 2
MIRT709595 ITPA inosine triphosphatase 2 2
MIRT710945 MRPL45 mitochondrial ribosomal protein L45 2 2
MIRT712345 NLN neurolysin 2 2
MIRT712530 CYTH2 cytohesin 2 2 2
MIRT714019 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT717287 ARMC12 armadillo repeat containing 12 2 2
MIRT717733 FGF1 fibroblast growth factor 1 2 2
MIRT718083 CLIC5 chloride intracellular channel 5 2 2
MIRT718562 MUC20 mucin 20, cell surface associated 2 2
MIRT721639 MYLK3 myosin light chain kinase 3 2 2
MIRT722632 C8A complement C8 alpha chain 2 2
MIRT723177 CDCA4 cell division cycle associated 4 2 2
MIRT725523 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-500b Methotrexate 126941 NSC740 approved resistant cell line (W1)
hsa-miR-500b-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-500b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-500b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-500b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-500b-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-500b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)

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