miRTarBase - #MIRT657375


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pre-miRNA Information
pre-miRNA hsa-mir-2355   
Genomic Coordinates chr2: 207109987 - 207110073
Description Homo sapiens miR-2355 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-2355-5p
Sequence 11| AUCCCCAGAUACAAUGGACAA |31
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 1 2 - 207110063 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1268296297 4 dbSNP
rs1361046879 5 dbSNP
rs1219551997 6 dbSNP
rs1295756820 12 dbSNP
rs1345273529 15 dbSNP
rs977145706 15 dbSNP
rs1209629984 20 dbSNP
rs759940260 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HMGA1   
Synonyms HMG-R, HMGA1A, HMGIY
Description high mobility group AT-hook 1
Transcript NM_002131   
Other Transcripts NM_145899 , NM_145901 , NM_145902 , NM_145903 , NM_145905   
Expression
Putative miRNA Targets on HMGA1
3'UTR of HMGA1
(miRNA target sites are highlighted)		 
>HMGA1|NM_002131|3'UTR
   1 CCCATGCGTGCCGCCTGCTCCTCACTGGAGGAGCAGCTTCCTTCTGGGACTGGACAGCTTTGCTCCGCTCCCACCGCCCC
  81 CACCCCTTCCCCAGGCCCACCATCACCACCGCCTCTGGCCGCCACCCCCATCTTCCACCTGTGCCCTCACCACCACACTA
 161 CACAGCACACCAGCCGCTGCAGGGCTCCCATGGGCTGAGTGGGGAGCAGTTTTCCCCTGGCCTCAGTTCCCAGCTCCCCC
 241 CGCCCACCCACGCATACACACATGCCCTCCTGGACAAGGCTAACATCCCACTTAGCCGCACCCTGCACCTGCTGCGTCCC
 321 CACTCCCTTGGTGGTGGGGACATTGCTCTCTGGGCTTTTGGTTTGGGGGCGCCCTCTCTGCTCCTTCACTGTTCCCTCTG
 401 GCTTCCCATAGTGGGGCCTGGGAGGGTTCCCCTGGCCTTAAAAGGGGCCCAAGCCCCATCTCATCCTGGCACGCCCTACT
 481 CCACTGCCCTGGCAGCAGCAGGTGTGGCCAATGGAGGGGGGTGCTGGCCCCCAGGATTCCCCCAGCCAAACTGTCTTTGT
 561 CACCACGTGGGGCTCACTTTTCATCCTTCCCCAACTTCCCTAGTCCCCGTACTAGGTTGGACAGCCCCCTTCGGTTACAG
 641 GAAGGCAGGAGGGGTGAGTCCCCTACTCCCTCTTCACTGTGGCCACAGCCCCCTTGCCCTCCGCCTGGGATCTGAGTACA
 721 TATTGTGGTGATGGAGATGCAGTCACTTATTGTCCAGGTGAGGCCCAAGAGCCCTGTGGCCGCCACCTGAGGTGGGCTGG
 801 GGCTGCTCCCCTAACCCTACTTTGCTTCCGCCACTCAGCCATTTCCCCCTCCTCAGATGGGGCACCAATAACAAGGAGCT
 881 CACCCTGCCCGCTCCCAACCCCCCTCCTGCTCCTCCCTGCCCCCCAAGGTTCTGGTTCCATTTTTCCTCTGTTCACAAAC
 961 TACCTCTGGACAGTTGTGTTGTTTTTTGTTCAATGTTCCATTCTTCGACATCCGTCATTGCTGCTGCTACCAGCGCCAAA
1041 TGTTCATCCTCATTGCCTCCTGTTCTGCCCACGATCCCCTCCCCCAAGATACTCTTTGTGGGGAAGAGGGGCTGGGGCAT
1121 GGCAGGCTGGGTGACCGACTACCCCAGTCCCAGGGAAGGTGGGGCCCTGCCCCTAGGATGCTGCAGCAGAGTGAGCAAGG
1201 GGGCCCAAATCGACCATAAAGGGTGTAGGGGCCACCTCCTCCCCCTGTTCTGTTGGGGAGGGGTAGCCATGATTTGTCCC
1281 AGCCTGGGGCTCCCTCTCTGGTTTCCTATTTGCAGTTACTTGAATAAAAAAAATATCCTTTTCTGGAAAAAAAAAAAAAA
1361 AAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aacaGGUAACAUAGACCCCUa 5'
              |::|| |: :|||||| 
Target 5' ccccCTGTTCTG-TTGGGGAg 3'
 1241 - 1260 136.00 -15.30
2 
miRNA  3' aacAGGUAACAUAGACCCCUa 5'
             ||| |||    |||||| 
Target 5' cacTCCCTTGGTGGTGGGGAc 3'
 321 - 341 126.00 -13.50
3 
miRNA  3' aaCAGGUAACAUAGACCCCUa 5'
            | |: ||| :|:|||||: 
Target 5' tgGGCTTTTG-GTTTGGGGGc 3'
 351 - 370 126.00 -14.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM5958929 19 COSMIC
COSM9394511 32 COSMIC
COSM9847894 77 COSMIC
COSM4590304 83 COSMIC
COSM9815441 83 COSMIC
COSM7319397 88 COSMIC
COSM9848484 95 COSMIC
COSM5996992 121 COSMIC
COSM1621547 145 COSMIC
COSM5512246 252 COSMIC
COSM1621548 303 COSMIC
COSM3784535 323 COSMIC
COSM8575563 423 COSMIC
COSM9371603 437 COSMIC
COSM7259299 479 COSMIC
COSM6994698 606 COSMIC
COSM9563391 610 COSMIC
COSM4595312 636 COSMIC
COSM8434511 640 COSMIC
COSM8413371 690 COSMIC
COSM5505187 704 COSMIC
COSM7608380 719 COSMIC
COSN31560009 741 COSMIC
COSN6319046 751 COSMIC
COSN30540261 765 COSMIC
COSN31484480 770 COSMIC
COSN19703020 783 COSMIC
COSN17078344 830 COSMIC
COSN9781128 837 COSMIC
COSN26466050 947 COSMIC
COSN5629450 1096 COSMIC
COSN15974416 1108 COSMIC
COSN23391964 1299 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773643332 5 dbSNP
rs1331211392 6 dbSNP
rs761589586 6 dbSNP
rs771892031 6 dbSNP
rs1229061581 7 dbSNP
rs766017108 8 dbSNP
rs373998742 9 dbSNP
rs1204261651 12 dbSNP
rs1264855109 13 dbSNP
rs759283212 14 dbSNP
rs1463388860 16 dbSNP
rs1204322201 19 dbSNP
rs1166110075 25 dbSNP
rs1368910793 26 dbSNP
rs1014079471 27 dbSNP
rs1262781153 28 dbSNP
rs1430492798 29 dbSNP
rs772826618 37 dbSNP
rs1428706480 39 dbSNP
rs1480780305 41 dbSNP
rs1179211858 42 dbSNP
rs1410319655 46 dbSNP
rs1453569920 48 dbSNP
rs1020054814 49 dbSNP
rs760323577 51 dbSNP
rs1289812670 52 dbSNP
rs1385270172 53 dbSNP
rs1383535196 54 dbSNP
rs1300859564 55 dbSNP
rs1183607020 56 dbSNP
rs1344328358 59 dbSNP
rs967127881 62 dbSNP
rs1285181377 63 dbSNP
rs999874702 64 dbSNP
rs1238115758 65 dbSNP
rs764643694 66 dbSNP
rs752273694 67 dbSNP
rs758268707 68 dbSNP
rs777697282 72 dbSNP
rs1268360569 74 dbSNP
rs751303861 75 dbSNP
rs757029639 76 dbSNP
rs557830810 77 dbSNP
rs781077291 78 dbSNP
rs1418971707 79 dbSNP
rs975410620 80 dbSNP
rs749447567 81 dbSNP
rs573143874 82 dbSNP
rs2780219 83 dbSNP
rs1427970886 84 dbSNP
rs1309911046 86 dbSNP
rs772659198 87 dbSNP
rs773888708 88 dbSNP
rs1304402049 89 dbSNP
rs1371159868 90 dbSNP
rs747591630 91 dbSNP
rs1390774543 93 dbSNP
rs1410721908 94 dbSNP
rs771177977 97 dbSNP
rs1318506570 99 dbSNP
rs1242257957 102 dbSNP
rs1451986512 103 dbSNP
rs1252011428 105 dbSNP
rs777114762 106 dbSNP
rs759111273 111 dbSNP
rs1360431420 112 dbSNP
rs1224870101 114 dbSNP
rs1249681940 121 dbSNP
rs574265056 122 dbSNP
rs1178286914 124 dbSNP
rs1253217889 125 dbSNP
rs1422496930 126 dbSNP
rs1183366422 127 dbSNP
rs1384273363 128 dbSNP
rs774927228 131 dbSNP
rs544847907 132 dbSNP
rs562344845 136 dbSNP
rs1460982488 140 dbSNP
rs1298688930 142 dbSNP
rs375019390 143 dbSNP
rs763975213 144 dbSNP
rs751465310 145 dbSNP
rs1383864381 149 dbSNP
rs1248470113 150 dbSNP
rs757264395 153 dbSNP
rs1307006927 155 dbSNP
rs1205294447 161 dbSNP
rs1253667799 162 dbSNP
rs767201678 170 dbSNP
rs940773178 176 dbSNP
rs368392959 177 dbSNP
rs545165232 180 dbSNP
rs560272359 181 dbSNP
rs1393918642 185 dbSNP
rs1416871355 186 dbSNP
rs1427465709 189 dbSNP
rs1455320149 190 dbSNP
rs527509695 191 dbSNP
rs1356247573 195 dbSNP
rs1468144180 197 dbSNP
rs1441505701 198 dbSNP
rs1335946017 199 dbSNP
rs1406582743 200 dbSNP
rs1454326479 202 dbSNP
rs758521351 204 dbSNP
rs949956883 208 dbSNP
rs1215283838 210 dbSNP
rs1297789891 221 dbSNP
rs548928964 222 dbSNP
rs1223477780 223 dbSNP
rs1485423938 225 dbSNP
rs1281111403 226 dbSNP
rs1264222950 229 dbSNP
rs903002981 230 dbSNP
rs1462943894 234 dbSNP
rs766225310 236 dbSNP
rs1207199789 237 dbSNP
rs1240065433 238 dbSNP
rs561103673 242 dbSNP
rs188629081 243 dbSNP
rs1421052727 246 dbSNP
rs1479147123 247 dbSNP
rs1175635525 248 dbSNP
rs1032730483 252 dbSNP
rs550002991 253 dbSNP
rs1397244084 254 dbSNP
rs753821579 256 dbSNP
rs1315927413 258 dbSNP
rs746261014 262 dbSNP
rs568959785 263 dbSNP
rs539441976 266 dbSNP
rs568187720 267 dbSNP
rs551496296 270 dbSNP
rs1284544528 271 dbSNP
rs1326269589 272 dbSNP
rs996565455 275 dbSNP
rs1435999890 277 dbSNP
rs1283978364 279 dbSNP
rs566606124 286 dbSNP
rs1216102966 287 dbSNP
rs1264798809 288 dbSNP
rs1361113836 292 dbSNP
rs1169285970 293 dbSNP
rs1489671889 294 dbSNP
rs1198062321 295 dbSNP
rs1269571609 296 dbSNP
rs773969172 298 dbSNP
rs767493668 299 dbSNP
rs1363679539 302 dbSNP
rs1258057250 303 dbSNP
rs534263154 304 dbSNP
rs987694238 305 dbSNP
rs759200105 312 dbSNP
rs1161566143 313 dbSNP
rs1363925599 315 dbSNP
rs1015102202 316 dbSNP
rs1303801600 317 dbSNP
rs1309697093 321 dbSNP
rs779484794 322 dbSNP
rs962169002 323 dbSNP
rs1279446561 324 dbSNP
rs1374514753 325 dbSNP
rs1225819529 327 dbSNP
rs1287799732 328 dbSNP
rs1280369488 329 dbSNP
rs1356788145 331 dbSNP
rs1461471303 335 dbSNP
rs1207923197 337 dbSNP
rs1245920399 339 dbSNP
rs1462167022 340 dbSNP
rs756006004 341 dbSNP
rs555690284 343 dbSNP
rs1460690370 345 dbSNP
rs796229715 346 dbSNP
rs1179584626 351 dbSNP
rs1232177977 353 dbSNP
rs766317647 354 dbSNP
rs11557700 356 dbSNP
rs752946938 362 dbSNP
rs142532394 365 dbSNP
rs1189947495 366 dbSNP
rs1383656772 367 dbSNP
rs758753247 370 dbSNP
rs777999103 371 dbSNP
rs1367559819 372 dbSNP
rs765108256 374 dbSNP
rs937401866 375 dbSNP
rs1336866794 376 dbSNP
rs1444865654 377 dbSNP
rs1313346504 382 dbSNP
rs1213487596 389 dbSNP
rs1335884980 390 dbSNP
rs1275646332 392 dbSNP
rs991533061 394 dbSNP
rs747119801 395 dbSNP
rs1244834863 397 dbSNP
rs757650780 403 dbSNP
rs1357868589 409 dbSNP
rs567797839 416 dbSNP
rs1272281739 417 dbSNP
rs1438290543 423 dbSNP
rs1378694243 424 dbSNP
rs1170885266 425 dbSNP
rs1200356634 426 dbSNP
rs781735212 428 dbSNP
rs538200876 430 dbSNP
rs1184444409 433 dbSNP
rs1370358014 435 dbSNP
rs1474506249 436 dbSNP
rs1323417720 441 dbSNP
rs1167376993 443 dbSNP
rs542568545 447 dbSNP
rs1412156502 450 dbSNP
rs949991297 451 dbSNP
rs746174678 456 dbSNP
rs1041578049 457 dbSNP
rs1363093979 462 dbSNP
rs1453766151 464 dbSNP
rs192998300 467 dbSNP
rs145863026 473 dbSNP
rs544998673 474 dbSNP
rs748922683 479 dbSNP
rs1469243015 481 dbSNP
rs1255271653 484 dbSNP
rs1339415052 485 dbSNP
rs1054693268 486 dbSNP
rs1350595760 487 dbSNP
rs1261103191 490 dbSNP
rs1460714731 494 dbSNP
rs1437904716 496 dbSNP
rs1204044050 501 dbSNP
rs1258579925 502 dbSNP
rs1319631244 504 dbSNP
rs1261783776 505 dbSNP
rs899604561 509 dbSNP
rs996988029 512 dbSNP
rs1029348192 516 dbSNP
rs1230500897 516 dbSNP
rs1445473398 517 dbSNP
rs1192685853 518 dbSNP
rs553772855 519 dbSNP
rs1289356876 522 dbSNP
rs1393344987 528 dbSNP
rs1323851926 531 dbSNP
rs1009160718 535 dbSNP
rs1397047983 539 dbSNP
rs1478807012 540 dbSNP
rs773666182 544 dbSNP
rs962604943 545 dbSNP
rs995037436 546 dbSNP
rs1470543404 547 dbSNP
rs1304923963 550 dbSNP
rs761400065 552 dbSNP
rs1380189748 553 dbSNP
rs1277550684 555 dbSNP
rs1317145382 556 dbSNP
rs1348196807 556 dbSNP
rs138006458 556 dbSNP
rs372041536 559 dbSNP
rs542666872 567 dbSNP
rs1281365376 568 dbSNP
rs11759910 569 dbSNP
rs752656250 571 dbSNP
rs1223942804 573 dbSNP
rs755474994 578 dbSNP
rs773171532 582 dbSNP
rs1204781257 583 dbSNP
rs1262627439 585 dbSNP
rs991957499 586 dbSNP
rs111748592 590 dbSNP
rs1268845000 593 dbSNP
rs1341589521 595 dbSNP
rs1481035248 596 dbSNP
rs1178804510 597 dbSNP
rs766266312 599 dbSNP
rs753754619 600 dbSNP
rs1166347548 601 dbSNP
rs1157647754 602 dbSNP
rs1360752226 605 dbSNP
rs1421061543 606 dbSNP
rs1300721007 607 dbSNP
rs1344271929 608 dbSNP
rs73419171 609 dbSNP
rs1303236518 610 dbSNP
rs372626790 620 dbSNP
rs1209563083 622 dbSNP
rs924573061 624 dbSNP
rs564825523 625 dbSNP
rs758593266 625 dbSNP
rs1238049182 626 dbSNP
rs757385064 627 dbSNP
rs1356090550 629 dbSNP
rs781165347 630 dbSNP
rs750904896 631 dbSNP
rs1054325412 632 dbSNP
rs1490521966 633 dbSNP
rs756668884 634 dbSNP
rs1150783 636 dbSNP
rs184349426 637 dbSNP
rs1418918946 639 dbSNP
rs749655115 646 dbSNP
rs1050797831 647 dbSNP
rs566486075 649 dbSNP
rs1409591117 653 dbSNP
rs1421162492 654 dbSNP
rs890870444 655 dbSNP
rs1364415129 656 dbSNP
rs1003919932 657 dbSNP
rs1457920597 660 dbSNP
rs1295284467 661 dbSNP
rs1408851095 662 dbSNP
rs375191354 664 dbSNP
rs779344492 666 dbSNP
rs1390649688 669 dbSNP
rs1309681119 670 dbSNP
rs1378769682 671 dbSNP
rs1244092864 674 dbSNP
rs1314546273 680 dbSNP
rs1360272284 682 dbSNP
rs1223846710 683 dbSNP
rs1250190345 687 dbSNP
rs527784847 689 dbSNP
rs747796445 690 dbSNP
rs1240450151 691 dbSNP
rs1443093890 697 dbSNP
rs549451959 703 dbSNP
rs145849177 704 dbSNP
rs538419054 706 dbSNP
rs1166256577 708 dbSNP
rs1371319384 710 dbSNP
rs1461436537 717 dbSNP
rs1211498946 720 dbSNP
rs1331910863 723 dbSNP
rs556924403 724 dbSNP
rs1271161001 725 dbSNP
rs777177218 725 dbSNP
rs1450118690 727 dbSNP
rs1336391651 730 dbSNP
rs1490551444 733 dbSNP
rs1380160844 739 dbSNP
rs1230140973 741 dbSNP
rs959088803 742 dbSNP
rs571991698 750 dbSNP
rs770999104 751 dbSNP
rs1219787246 753 dbSNP
rs1260485223 756 dbSNP
rs1460303905 757 dbSNP
rs563499231 762 dbSNP
rs1242186183 763 dbSNP
rs1483358119 767 dbSNP
rs1394204570 769 dbSNP
rs115929552 774 dbSNP
rs1259098295 777 dbSNP
rs1427342636 780 dbSNP
rs759430066 782 dbSNP
rs1156336595 783 dbSNP
rs144540283 786 dbSNP
rs1334493771 787 dbSNP
rs553813535 788 dbSNP
rs1180089991 797 dbSNP
rs371593640 801 dbSNP
rs1366822318 804 dbSNP
rs1221951902 809 dbSNP
rs990451434 814 dbSNP
rs1473877752 817 dbSNP
rs542405032 818 dbSNP
rs1351456495 821 dbSNP
rs2780218 825 dbSNP
rs2780217 826 dbSNP
rs932510371 828 dbSNP
rs1164058111 830 dbSNP
rs1419179458 831 dbSNP
rs537322378 837 dbSNP
rs1439006898 844 dbSNP
rs1343972827 845 dbSNP
rs1318220107 847 dbSNP
rs1310380725 848 dbSNP
rs1371755964 850 dbSNP
rs912338027 852 dbSNP
rs939736146 855 dbSNP
rs1394028695 857 dbSNP
rs1191586611 858 dbSNP
rs1240329452 862 dbSNP
rs1489329414 862 dbSNP
rs150982394 863 dbSNP
rs1214983562 864 dbSNP
rs1310491365 868 dbSNP
rs1036709872 873 dbSNP
rs1208735941 873 dbSNP
rs1448228994 879 dbSNP
rs1302186499 881 dbSNP
rs1221342075 884 dbSNP
rs1269290624 885 dbSNP
rs1270196283 886 dbSNP
rs898130342 888 dbSNP
rs1362937741 891 dbSNP
rs73419174 892 dbSNP
rs1374495084 897 dbSNP
rs1049745196 899 dbSNP
rs894721330 902 dbSNP
rs1013080232 903 dbSNP
rs1230388588 904 dbSNP
rs10947489 905 dbSNP
rs1478110198 908 dbSNP
rs1265196575 918 dbSNP
rs1185929641 920 dbSNP
rs1485373965 922 dbSNP
rs1256851945 927 dbSNP
rs907325763 928 dbSNP
rs564711337 930 dbSNP
rs1306179458 937 dbSNP
rs200521247 947 dbSNP
rs998867948 950 dbSNP
rs532281980 970 dbSNP
rs201779449 976 dbSNP
rs1219553727 977 dbSNP
rs1342967715 978 dbSNP
rs1208683436 979 dbSNP
rs1254094588 982 dbSNP
rs1412431575 982 dbSNP
rs1377804914 985 dbSNP
rs140481117 994 dbSNP
rs1188487514 997 dbSNP
rs540878901 1004 dbSNP
rs560158096 1007 dbSNP
rs527673741 1008 dbSNP
rs549245060 1011 dbSNP
rs149013137 1015 dbSNP
rs1185668147 1018 dbSNP
rs750856264 1022 dbSNP
rs1256938715 1030 dbSNP
rs1391190725 1035 dbSNP
rs986661229 1036 dbSNP
rs912368599 1038 dbSNP
rs939768653 1045 dbSNP
rs1434600337 1050 dbSNP
rs1171340564 1053 dbSNP
rs1403705803 1058 dbSNP
rs1396173989 1062 dbSNP
rs1322791829 1064 dbSNP
rs1317160117 1069 dbSNP
rs17038619 1073 dbSNP
rs1436864649 1074 dbSNP
rs1298014583 1078 dbSNP
rs879589872 1085 dbSNP
rs919612284 1088 dbSNP
rs147082929 1093 dbSNP
rs1054798737 1095 dbSNP
rs1368911696 1095 dbSNP
rs1417343306 1098 dbSNP
rs571830852 1099 dbSNP
rs1201147220 1104 dbSNP
rs1459418864 1108 dbSNP
rs1251541210 1117 dbSNP
rs1283797854 1127 dbSNP
rs991588253 1133 dbSNP
rs1213390861 1134 dbSNP
rs1489111752 1137 dbSNP
rs948960263 1138 dbSNP
rs1190786535 1144 dbSNP
rs1314583842 1150 dbSNP
rs1308161803 1155 dbSNP
rs1248961791 1159 dbSNP
rs1378582500 1161 dbSNP
rs915649170 1161 dbSNP
rs1454154546 1165 dbSNP
rs1045889755 1171 dbSNP
rs907358404 1172 dbSNP
rs539344658 1174 dbSNP
rs998899261 1188 dbSNP
rs548106813 1193 dbSNP
rs1032205407 1194 dbSNP
rs375086146 1197 dbSNP
rs1379922715 1201 dbSNP
rs1466086669 1207 dbSNP
rs1150782 1208 dbSNP
rs1012014555 1211 dbSNP
rs1193429112 1212 dbSNP
rs41269030 1213 dbSNP
rs772035549 1226 dbSNP
rs1270146273 1229 dbSNP
rs1196988716 1230 dbSNP
rs1458431537 1235 dbSNP
rs1484639376 1238 dbSNP
rs1284701543 1239 dbSNP
rs554398196 1246 dbSNP
rs3197257 1251 dbSNP
rs1393436175 1254 dbSNP
rs1232319039 1261 dbSNP
rs1274343165 1264 dbSNP
rs879394138 1268 dbSNP
rs576111157 1270 dbSNP
rs1359750789 1271 dbSNP
rs536715260 1272 dbSNP
rs961165424 1279 dbSNP
rs1172183849 1283 dbSNP
rs1379717805 1284 dbSNP
rs1238268806 1286 dbSNP
rs780882116 1289 dbSNP
rs1191411376 1294 dbSNP
rs2797 1296 dbSNP
rs972585859 1300 dbSNP
rs919712523 1309 dbSNP
rs1193776147 1315 dbSNP
rs1277793552 1318 dbSNP
rs1488970005 1318 dbSNP
rs1199520328 1323 dbSNP
rs1257548693 1326 dbSNP
rs931062273 1326 dbSNP
rs558332304 1327 dbSNP
rs1269084103 1334 dbSNP
rs576622661 1337 dbSNP
rs777562460 1339 dbSNP
rs1401969353 1345 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aacagguaacauaGACCCCua 5'
                       ||||||  
Target 5' -----aagaggggCUGGGGc- 3'
 		1 - 15
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000347617.6 | 3UTR | AAGAGGGGCUGGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.456 0 0.502 0 32 Click to see details
LUAD 0.587 0.02 0.552 0.03 12 Click to see details
KICH 0.331 0.05 0.254 0.11 25 Click to see details
LUSC 0.219 0.09 0.196 0.12 38 Click to see details
BRCA -0.124 0.13 -0.128 0.12 84 Click to see details
UCEC -0.241 0.16 -0.165 0.25 19 Click to see details
BLCA 0.183 0.23 0.191 0.22 18 Click to see details
PCPG -0.645 0.28 -0.500 0.33 3 Click to see details
THCA -0.072 0.29 -0.128 0.17 59 Click to see details
HNSC -0.086 0.29 -0.057 0.36 42 Click to see details
KIRC -0.061 0.31 -0.059 0.32 68 Click to see details
KIRP 0.089 0.31 0.074 0.34 32 Click to see details
LIHC 0.05 0.37 0.123 0.2 49 Click to see details
PRAD -0.043 0.38 -0.070 0.31 50 Click to see details
ESCA 0.066 0.42 -0.200 0.28 11 Click to see details
CESC 0.229 0.43 0.500 0.33 3 Click to see details
CHOL -0.038 0.46 0.200 0.3 9 Click to see details
PAAD 0.025 0.49 -0.400 0.3 4 Click to see details
PAAD 0.025 0.49 -0.400 0.3 4 Click to see details
164 hsa-miR-2355-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT190653 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT286477 TAOK1 TAO kinase 1 2 4
MIRT318993 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT345622 DCAF7 DDB1 and CUL4 associated factor 7 2 4
MIRT442513 SYT7 synaptotagmin 7 2 4
MIRT444247 CTNND1 catenin delta 1 2 2
MIRT444780 ECE1 endothelin converting enzyme 1 2 2
MIRT456525 TMEM63A transmembrane protein 63A 2 2
MIRT468960 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT469834 R3HDM4 R3H domain containing 4 2 2
MIRT470027 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT471167 PHB2 prohibitin 2 2 2
MIRT475819 HDGF heparin binding growth factor 2 4
MIRT479389 CDKN1B cyclin dependent kinase inhibitor 1B 2 6
MIRT481747 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT485220 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT487259 CCNF cyclin F 2 2
MIRT489971 MCC mutated in colorectal cancers 2 4
MIRT491399 C1D C1D nuclear receptor corepressor 2 2
MIRT494959 CCDC144A coiled-coil domain containing 144A 2 4
MIRT494979 PPP5D1 PPP5 tetratricopeptide repeat domain containing 1 2 2
MIRT495225 CHST14 carbohydrate sulfotransferase 14 2 2
MIRT496550 TBX15 T-box 15 2 2
MIRT501612 PISD phosphatidylserine decarboxylase 2 2
MIRT509393 TRIM24 tripartite motif containing 24 2 2
MIRT519616 ZNF788 zinc finger family member 788 2 4
MIRT519738 ZNF394 zinc finger protein 394 2 4
MIRT521230 SAR1A secretion associated Ras related GTPase 1A 2 4
MIRT521801 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT526233 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526932 CMSS1 cms1 ribosomal small subunit homolog (yeast) 2 2
MIRT529189 ACBD7 acyl-CoA binding domain containing 7 2 2
MIRT529329 ZNF649 zinc finger protein 649 2 2
MIRT529698 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529921 TOP1MT DNA topoisomerase I mitochondrial 2 2
MIRT530032 SMC1A structural maintenance of chromosomes 1A 2 2
MIRT530898 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT531621 TM4SF5 transmembrane 4 L six family member 5 2 4
MIRT533132 XIAP X-linked inhibitor of apoptosis 2 2
MIRT533210 WAPAL WAPL cohesin release factor 2 2
MIRT534058 ST6GALNAC3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 2 2
MIRT535487 PARVB parvin beta 2 2
MIRT536749 HOXD9 homeobox D9 2 2
MIRT551456 CARKD NAD(P)HX dehydratase 2 2
MIRT551858 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT552095 FAM8A1 family with sequence similarity 8 member A1 2 2
MIRT552332 ZNF704 zinc finger protein 704 2 2
MIRT552549 ZFP36L2 ZFP36 ring finger protein like 2 2 2
MIRT561505 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT562702 ZNF415 zinc finger protein 415 2 2
MIRT563052 ZNF138 zinc finger protein 138 2 2
MIRT564592 ZNF791 zinc finger protein 791 2 2
MIRT566422 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 2
MIRT570176 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT570866 ZNF525 zinc finger protein 525 2 2
MIRT570875 ZFP1 ZFP1 zinc finger protein 2 2
MIRT571517 ZNF625 zinc finger protein 625 2 2
MIRT572551 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT610894 HINFP histone H4 transcription factor 2 2
MIRT611037 PTGES prostaglandin E synthase 2 2
MIRT611479 HSPA4 heat shock protein family A (Hsp70) member 4 2 4
MIRT612419 SP1 Sp1 transcription factor 2 2
MIRT614478 FRMPD3 FERM and PDZ domain containing 3 2 2
MIRT616318 CACNA1A calcium voltage-gated channel subunit alpha1 A 2 2
MIRT616929 ZNF638 zinc finger protein 638 2 2
MIRT618131 GABARAPL3 GABA type A receptor associated protein like 3 pseudogene 2 2
MIRT618452 ZFP30 ZFP30 zinc finger protein 2 4
MIRT620671 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620713 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT621126 EMC7 ER membrane protein complex subunit 7 2 4
MIRT621443 TOMM22 translocase of outer mitochondrial membrane 22 2 2
MIRT623491 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623783 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT623918 FNBP1L formin binding protein 1 like 2 2
MIRT625723 CXorf38 chromosome X open reading frame 38 2 2
MIRT625778 GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2 2
MIRT626940 TTR transthyretin 2 2
MIRT627357 TSC22D2 TSC22 domain family member 2 2 2
MIRT632078 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT633361 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT639793 MVK mevalonate kinase 2 2
MIRT643761 NAGK N-acetylglucosamine kinase 2 2
MIRT644358 NDUFAF6 NADH:ubiquinone oxidoreductase complex assembly factor 6 2 2
MIRT645558 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT646588 ANKRD36 ankyrin repeat domain 36 2 2
MIRT646631 SLC25A46 solute carrier family 25 member 46 2 2
MIRT648066 HSPA6 heat shock protein family A (Hsp70) member 6 2 2
MIRT648142 SUCLG2 succinate-CoA ligase GDP-forming beta subunit 2 2
MIRT648416 MYOZ3 myozenin 3 2 2
MIRT649218 AMMECR1L AMMECR1 like 2 2
MIRT649772 MRPS27 mitochondrial ribosomal protein S27 2 4
MIRT650510 UFM1 ubiquitin fold modifier 1 2 2
MIRT651007 ZNF740 zinc finger protein 740 2 2
MIRT651524 WNT2B Wnt family member 2B 2 2
MIRT652014 TTYH3 tweety family member 3 2 2
MIRT652513 TMEM109 transmembrane protein 109 2 2
MIRT652686 THUMPD3 THUMP domain containing 3 2 2
MIRT652772 TENM3 teneurin transmembrane protein 3 2 2
MIRT653160 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT653765 SIX5 SIX homeobox 5 2 2
MIRT653792 SIRPA signal regulatory protein alpha 2 2
MIRT655649 OAZ2 ornithine decarboxylase antizyme 2 2 2
MIRT656263 MEX3A mex-3 RNA binding family member A 2 2
MIRT657044 KCNH6 potassium voltage-gated channel subfamily H member 6 2 2
MIRT657375 HMGA1 high mobility group AT-hook 1 2 2
MIRT657532 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT657542 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657828 GJD3 gap junction protein delta 3 2 2
MIRT658946 DOK6 docking protein 6 2 2
MIRT660363 BACH2 BTB domain and CNC homolog 2 2 2
MIRT660406 ATXN7L3 ataxin 7 like 3 2 2
MIRT660948 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661031 AAK1 AP2 associated kinase 1 2 2
MIRT662435 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT668419 FAM217B family with sequence similarity 217 member B 2 2
MIRT669332 BSND barttin CLCNK type accessory beta subunit 2 2
MIRT676105 CLUAP1 clusterin associated protein 1 2 2
MIRT677084 SMIM15 small integral membrane protein 15 2 2
MIRT677127 OGFOD3 2-oxoglutarate and iron dependent oxygenase domain containing 3 2 2
MIRT678001 CPM carboxypeptidase M 2 2
MIRT678531 TMEM78 transmembrane protein 78 2 2
MIRT680000 ZNF860 zinc finger protein 860 2 2
MIRT680098 PXMP4 peroxisomal membrane protein 4 2 2
MIRT686795 SOX12 SRY-box 12 2 2
MIRT698887 SPTBN2 spectrin beta, non-erythrocytic 2 2 2
MIRT699371 SLC30A6 solute carrier family 30 member 6 2 2
MIRT702005 MIDN midnolin 2 2
MIRT708101 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT709563 GYG2 glycogenin 2 2 2
MIRT710559 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT710585 CDCA4 cell division cycle associated 4 2 2
MIRT710873 NT5DC1 5'-nucleotidase domain containing 1 2 2
MIRT711876 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712226 RIMS3 regulating synaptic membrane exocytosis 3 2 2
MIRT713211 FAM13A family with sequence similarity 13 member A 2 2
MIRT713261 GPR55 G protein-coupled receptor 55 2 2
MIRT713327 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT713889 RNF19B ring finger protein 19B 2 2
MIRT714015 UBAP2L ubiquitin associated protein 2 like 2 2
MIRT714202 NLRP12 NLR family pyrin domain containing 12 2 2
MIRT714717 VPS8 VPS8, CORVET complex subunit 2 2
MIRT714748 ZNF385D zinc finger protein 385D 2 2
MIRT714806 ARHGEF19 Rho guanine nucleotide exchange factor 19 2 2
MIRT714852 ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 2 2
MIRT715717 MRPL4 mitochondrial ribosomal protein L4 2 2
MIRT715852 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT716853 MFSD12 major facilitator superfamily domain containing 12 2 2
MIRT717134 EBPL emopamil binding protein like 2 2
MIRT717248 TMEM246 transmembrane protein 246 2 2
MIRT717997 ZNF79 zinc finger protein 79 2 2
MIRT718341 PURA purine rich element binding protein A 2 2
MIRT719587 TFCP2L1 transcription factor CP2 like 1 2 2
MIRT720520 PTGR2 prostaglandin reductase 2 2 2
MIRT720671 SLC39A13 solute carrier family 39 member 13 2 2
MIRT721213 DCLK3 doublecortin like kinase 3 2 2
MIRT721757 INF2 inverted formin, FH2 and WH2 domain containing 2 2
MIRT721826 POU6F1 POU class 6 homeobox 1 2 2
MIRT722091 SUSD1 sushi domain containing 1 2 2
MIRT722275 LURAP1 leucine rich adaptor protein 1 2 2
MIRT722802 ARHGAP19 Rho GTPase activating protein 19 2 2
MIRT722866 FAM212B family with sequence similarity 212 member B 2 2
MIRT723113 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT724378 NEK8 NIMA related kinase 8 2 2
MIRT732775 PYCR1 pyrroline-5-carboxylate reductase 1 3 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2355 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2355-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-2355-5p Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-2355-5p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, HCC827)
hsa-miR-2355-5p Gefitinib 123631 NSC715055 approved resistant High Non-Small Cell Lung Cancer cell line (A549, HCC827)
hsa-miR-2355-5p Temozolomide 5394 NSC362856 approved resistant High Glioma tissue
hsa-miR-2355-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-2355-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-2355-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2355-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2355-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVSAHO)

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