pre-miRNA Information
pre-miRNA hsa-mir-2355   
Genomic Coordinates chr2: 207109987 - 207110073
Description Homo sapiens miR-2355 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-2355-5p
Sequence 11| AUCCCCAGAUACAAUGGACAA |31
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 1 2 - 207110063 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1268296297 4 dbSNP
rs1361046879 5 dbSNP
rs1219551997 6 dbSNP
rs1295756820 12 dbSNP
rs1345273529 15 dbSNP
rs977145706 15 dbSNP
rs1209629984 20 dbSNP
rs759940260 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GTDC1   
Synonyms Hmat-Xa, mat-Xa
Description glycosyltransferase like domain containing 1
Transcript NM_001006636   
Other Transcripts NM_001164629 , NM_024659   
Expression
Putative miRNA Targets on GTDC1
3'UTR of GTDC1
(miRNA target sites are highlighted)
>GTDC1|NM_001006636|3'UTR
   1 CAGATGGGGCTAAGTCACAAACTTGCAGCCTAAGGCAGAATCTGAAGAACTTTCCAGAGTGTGCCCATATTTACCTGATC
  81 AGAGAGAAAAGAAAATCTGCAGAGGAAGCTGAGCCTGGCTGCTTGTCATAGCTGACACAGAGCCATCTGCCACAAACCTG
 161 TGGCGGCTTCAGATCTCCAATCCCTGCCACCACCCCAACTCAAATTAAATACAGATTCCTAGAGACGTTATGATGGTTAC
 241 ACATGTCCTCGGCATCACATGTAGGAGACTGTTCAAAAAAAATATGTGGCCTGTTGTATAACCGCACTCATGTATCCCAT
 321 ATGTGGTGCCACATTGAATTTCCGGTTGAATCCGTTTTTATCCTTTGTACTGGATGACATGGTGCCTGAATTCTTTCTTT
 401 TCGCCGACACGATGGCAGCCAAACTGCAGCTTCAAACGCTCACACTTGGCTGGGTTTCTACCTAGGTTGCCAGGTTATCA
 481 TCGGAGCCTTCTTGTGTCCTCAAAGGGCCACGAGGCCTGAAAGGAGGATCAGAATGCTTTGGGATTAATTGGGCAGCCAT
 561 CGCAGAATTGTTTGTGGGCAAAGGGCTGCTTTAGCACTTTTCTTTTAGCAAATTAATGACTCTCAGGCACAGGGGGTTTT
 641 AAGTGAAGGTATTAATAAGAGGTCTGGCAGGTATTCCCATGATTCACAGAGTTACATTTGCATTTAATTAATCTTAAAGT
 721 TGCAAGATAAACAGCTGTAATTCGGACAAACATGACAAACACAGTGAAGCCAACTATCCCATAAAATGAACACTGACATA
 801 CTTGTTTTAATTTTTTTCCCAGCGTAAAAATAGAAAAATCAAAATACTCCTAACAAAACCAGTGATTTTGATAGAAATAT
 881 TTCTCCAATATACTTGCATCCACCTACAAATATAACCTTTTCAAGATAAATCGCTTATGATTTCAATAGTCAAACTGCTG
 961 TGTTTGTTGATGTAAAGATGTTTTGAATGGCTAGATGGTAAAATAAATTCTTAATAAAGTACCCACTGCAATTTTTAAAA
1041 AAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aacAGGUAACAUAGACCccua 5'
             ||| ||||| ||||    
Target 5' ttaTCCTTTGTA-CTGGatga 3'
358 - 377 109.00 -11.90
2
miRNA  3' aacAG-GUAACAUAGACCCcua 5'
             || || | |: |||||   
Target 5' cgcTCACACT-TGGCTGGGttt 3'
437 - 457 109.00 -9.22
3
miRNA  3' aacaggUAACAUAGACCCCUa 5'
                ||||| | |||| | 
Target 5' cgcagaATTGTTTGTGGGCAa 3'
561 - 581 103.00 -9.02
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30522068 3 COSMIC
COSN31599073 14 COSMIC
COSN30499090 22 COSMIC
COSN30508329 51 COSMIC
COSN508526 86 COSMIC
COSN30164176 140 COSMIC
COSN20074539 164 COSMIC
COSN9861769 165 COSMIC
COSN23998529 222 COSMIC
COSN1794677 226 COSMIC
COSN31603356 343 COSMIC
COSN31597320 402 COSMIC
COSN23522340 403 COSMIC
COSN7344859 447 COSMIC
COSN31576957 465 COSMIC
COSN6194531 478 COSMIC
COSN8607609 482 COSMIC
COSN24299075 510 COSMIC
COSN31480976 519 COSMIC
COSN31595460 563 COSMIC
COSN16506088 689 COSMIC
COSN23730625 1154 COSMIC
COSN30341303 1466 COSMIC
COSN9065887 1780 COSMIC
COSN20097213 2119 COSMIC
COSN23189943 2329 COSMIC
COSN21973508 2370 COSMIC
COSN22157454 2464 COSMIC
COSN17121747 2502 COSMIC
COSN22643093 2546 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780069606 8 dbSNP
rs1301477508 9 dbSNP
rs1420352315 11 dbSNP
rs767332988 12 dbSNP
rs1397047227 17 dbSNP
rs1327406409 18 dbSNP
rs759368176 22 dbSNP
rs371348248 26 dbSNP
rs1328362802 32 dbSNP
rs576790834 36 dbSNP
rs1390239481 41 dbSNP
rs761947879 50 dbSNP
rs951739589 53 dbSNP
rs1340831078 61 dbSNP
rs1027166575 79 dbSNP
rs1260498093 96 dbSNP
rs758644671 104 dbSNP
rs995711654 110 dbSNP
rs1212331212 121 dbSNP
rs558904138 125 dbSNP
rs897327867 127 dbSNP
rs1215244564 143 dbSNP
rs1257338471 144 dbSNP
rs1335453273 156 dbSNP
rs1037714155 157 dbSNP
rs997954141 164 dbSNP
rs550709063 165 dbSNP
rs779079603 193 dbSNP
rs1242959055 196 dbSNP
rs1476432047 197 dbSNP
rs1008467746 198 dbSNP
rs1217299892 199 dbSNP
rs914887201 211 dbSNP
rs532277358 226 dbSNP
rs757710377 227 dbSNP
rs1386611720 232 dbSNP
rs571034597 236 dbSNP
rs1318531762 243 dbSNP
rs1270707695 251 dbSNP
rs1401689860 260 dbSNP
rs1277029960 267 dbSNP
rs891133745 271 dbSNP
rs1335318429 273 dbSNP
rs1049710648 274 dbSNP
rs1235090181 283 dbSNP
rs1338328354 283 dbSNP
rs927501139 285 dbSNP
rs932745514 288 dbSNP
rs1355342852 296 dbSNP
rs754136015 303 dbSNP
rs552540243 304 dbSNP
rs971543387 307 dbSNP
rs1262607565 311 dbSNP
rs1054465568 318 dbSNP
rs1190670691 319 dbSNP
rs917456922 325 dbSNP
rs1415451142 332 dbSNP
rs200075913 343 dbSNP
rs756507083 344 dbSNP
rs187090673 353 dbSNP
rs1386606132 354 dbSNP
rs1398596531 366 dbSNP
rs981776350 369 dbSNP
rs961445851 377 dbSNP
rs1355562588 379 dbSNP
rs949972541 382 dbSNP
rs1173269001 390 dbSNP
rs1477162253 401 dbSNP
rs1423510657 402 dbSNP
rs1192352837 403 dbSNP
rs142859776 405 dbSNP
rs767086243 406 dbSNP
rs991121941 408 dbSNP
rs530054999 410 dbSNP
rs951686572 411 dbSNP
rs1258541379 415 dbSNP
rs1220221397 423 dbSNP
rs1285640019 426 dbSNP
rs954066392 437 dbSNP
rs1277448980 438 dbSNP
rs1027447208 439 dbSNP
rs1423757289 455 dbSNP
rs558616838 460 dbSNP
rs1365941978 467 dbSNP
rs1468237391 473 dbSNP
rs971790418 479 dbSNP
rs538906352 482 dbSNP
rs562578536 483 dbSNP
rs1447661458 494 dbSNP
rs901004074 494 dbSNP
rs1042262345 498 dbSNP
rs1015734286 512 dbSNP
rs1333747854 517 dbSNP
rs1333851819 531 dbSNP
rs1008914985 541 dbSNP
rs1053958701 542 dbSNP
rs1348938470 543 dbSNP
rs544278699 544 dbSNP
rs891342854 549 dbSNP
rs926305486 561 dbSNP
rs774184710 562 dbSNP
rs1196906568 569 dbSNP
rs1253341258 570 dbSNP
rs576972183 574 dbSNP
rs1044661461 583 dbSNP
rs182585056 600 dbSNP
rs1028985459 603 dbSNP
rs996842048 606 dbSNP
rs950320384 626 dbSNP
rs1173298238 632 dbSNP
rs1166226660 633 dbSNP
rs917509324 634 dbSNP
rs1423906502 643 dbSNP
rs1394327936 654 dbSNP
rs893120183 655 dbSNP
rs1360740122 656 dbSNP
rs1371909104 661 dbSNP
rs1443420257 666 dbSNP
rs1299220636 667 dbSNP
rs116007755 668 dbSNP
rs1228292619 672 dbSNP
rs940198529 676 dbSNP
rs573044687 679 dbSNP
rs1179600511 681 dbSNP
rs761535240 689 dbSNP
rs1472293024 693 dbSNP
rs1189081795 695 dbSNP
rs1266284465 706 dbSNP
rs934715880 707 dbSNP
rs903031462 712 dbSNP
rs1171972171 713 dbSNP
rs1176515936 713 dbSNP
rs909946241 713 dbSNP
rs1464850089 716 dbSNP
rs1421316488 718 dbSNP
rs762822640 721 dbSNP
rs1165323527 722 dbSNP
rs950018974 728 dbSNP
rs189026966 744 dbSNP
rs1367243052 747 dbSNP
rs769802549 752 dbSNP
rs1297822502 755 dbSNP
rs1339038885 762 dbSNP
rs1218593767 763 dbSNP
rs1274408689 766 dbSNP
rs185916563 769 dbSNP
rs1219914872 772 dbSNP
rs1222140749 774 dbSNP
rs1264477692 776 dbSNP
rs1485996782 788 dbSNP
rs1187690520 793 dbSNP
rs930320607 796 dbSNP
rs1323429005 808 dbSNP
rs1310742272 811 dbSNP
rs776531896 813 dbSNP
rs971821594 814 dbSNP
rs961797868 816 dbSNP
rs866159076 823 dbSNP
rs1016184913 824 dbSNP
rs987021213 839 dbSNP
rs1163826924 845 dbSNP
rs893648899 861 dbSNP
rs1454532272 863 dbSNP
rs1300062540 880 dbSNP
rs1358683532 887 dbSNP
rs181676446 889 dbSNP
rs1399524592 897 dbSNP
rs1032072865 903 dbSNP
rs1001988654 905 dbSNP
rs1312461105 916 dbSNP
rs776917212 916 dbSNP
rs955725008 919 dbSNP
rs949042008 922 dbSNP
rs1283499024 925 dbSNP
rs1028555576 933 dbSNP
rs1211060469 941 dbSNP
rs997039931 944 dbSNP
rs1259511998 953 dbSNP
rs557021934 960 dbSNP
rs1037710595 971 dbSNP
rs1181027927 978 dbSNP
rs1348629527 983 dbSNP
rs538732062 998 dbSNP
rs571404699 1005 dbSNP
rs1420710676 1006 dbSNP
rs1162143593 1010 dbSNP
rs1378774774 1010 dbSNP
rs940186942 1013 dbSNP
rs1313570911 1015 dbSNP
rs1361335516 1018 dbSNP
rs1446496807 1022 dbSNP
rs910067850 1049 dbSNP
rs984212186 1064 dbSNP
rs1242817374 1069 dbSNP
rs893149869 1070 dbSNP
rs1404207921 1071 dbSNP
rs1380558992 1073 dbSNP
rs1032948767 1074 dbSNP
rs1180071476 1078 dbSNP
rs759874721 1079 dbSNP
rs1352600210 1090 dbSNP
rs1234298931 1092 dbSNP
rs552693598 1095 dbSNP
rs999345468 1096 dbSNP
rs1209309591 1102 dbSNP
rs1233432181 1108 dbSNP
rs772182677 1109 dbSNP
rs1046227341 1111 dbSNP
rs527903328 1118 dbSNP
rs787174 1119 dbSNP
rs965361638 1127 dbSNP
rs201238279 1128 dbSNP
rs1354445975 1136 dbSNP
rs141682011 1140 dbSNP
rs776939245 1150 dbSNP
rs1020845732 1151 dbSNP
rs920277032 1152 dbSNP
rs1035991200 1171 dbSNP
rs76821106 1176 dbSNP
rs1353258593 1179 dbSNP
rs1329742901 1183 dbSNP
rs957889044 1196 dbSNP
rs1441208673 1211 dbSNP
rs1276300839 1213 dbSNP
rs1342227829 1216 dbSNP
rs1218203945 1217 dbSNP
rs1273616070 1218 dbSNP
rs911684374 1241 dbSNP
rs987606851 1246 dbSNP
rs1302477247 1248 dbSNP
rs1196451401 1252 dbSNP
rs1388861741 1254 dbSNP
rs1237373492 1258 dbSNP
rs1032630384 1259 dbSNP
rs1194477719 1272 dbSNP
rs1366161416 1281 dbSNP
rs1248713198 1291 dbSNP
rs1190741044 1298 dbSNP
rs757361629 1299 dbSNP
rs1002041083 1303 dbSNP
rs921401479 1305 dbSNP
rs369303419 1308 dbSNP
rs975654241 1310 dbSNP
rs904910547 1313 dbSNP
rs1160090934 1322 dbSNP
rs957577267 1329 dbSNP
rs1417543305 1331 dbSNP
rs1325113957 1332 dbSNP
rs1013235920 1334 dbSNP
rs1435058446 1335 dbSNP
rs562540385 1337 dbSNP
rs749664519 1344 dbSNP
rs1270279220 1351 dbSNP
rs1342247982 1358 dbSNP
rs897510065 1366 dbSNP
rs1037275250 1368 dbSNP
rs1176577036 1375 dbSNP
rs1335198410 1376 dbSNP
rs940298332 1382 dbSNP
rs1265212938 1391 dbSNP
rs1190497527 1394 dbSNP
rs1032979636 1402 dbSNP
rs544241476 1405 dbSNP
rs1265520990 1406 dbSNP
rs1198167887 1408 dbSNP
rs1242800027 1413 dbSNP
rs919915963 1416 dbSNP
rs967782489 1419 dbSNP
rs1423633661 1420 dbSNP
rs532431049 1423 dbSNP
rs1256774625 1429 dbSNP
rs1165379492 1434 dbSNP
rs565236949 1441 dbSNP
rs147814870 1443 dbSNP
rs894327927 1447 dbSNP
rs572968700 1448 dbSNP
rs1342933746 1449 dbSNP
rs1299553503 1452 dbSNP
rs1277480437 1457 dbSNP
rs1238483056 1467 dbSNP
rs1397554831 1473 dbSNP
rs1246638973 1474 dbSNP
rs1055613296 1478 dbSNP
rs1354451998 1485 dbSNP
rs913920105 1491 dbSNP
rs3731956 1493 dbSNP
rs1467405960 1494 dbSNP
rs542918972 1524 dbSNP
rs1263032142 1525 dbSNP
rs375392801 1527 dbSNP
rs899048689 1528 dbSNP
rs958155511 1529 dbSNP
rs1190006661 1536 dbSNP
rs1478142886 1537 dbSNP
rs925232881 1541 dbSNP
rs1158752286 1544 dbSNP
rs1425653539 1546 dbSNP
rs1417304632 1549 dbSNP
rs1036278364 1554 dbSNP
rs969230030 1561 dbSNP
rs1487979531 1575 dbSNP
rs140560332 1576 dbSNP
rs556985114 1585 dbSNP
rs771449122 1595 dbSNP
rs961727003 1608 dbSNP
rs1051533744 1609 dbSNP
rs1310250386 1610 dbSNP
rs1356145416 1610 dbSNP
rs1015041181 1614 dbSNP
rs538643145 1618 dbSNP
rs1005885977 1631 dbSNP
rs1202676802 1635 dbSNP
rs547981265 1645 dbSNP
rs761028876 1654 dbSNP
rs1276815043 1656 dbSNP
rs1216281317 1662 dbSNP
rs1179718927 1668 dbSNP
rs1048638739 1669 dbSNP
rs1325296468 1674 dbSNP
rs996946340 1682 dbSNP
rs552811210 1684 dbSNP
rs1467172106 1690 dbSNP
rs1041095690 1695 dbSNP
rs1312997803 1698 dbSNP
rs1401483398 1710 dbSNP
rs944159042 1711 dbSNP
rs1397487720 1712 dbSNP
rs921433896 1719 dbSNP
rs975517267 1720 dbSNP
rs372340656 1724 dbSNP
rs1444875387 1729 dbSNP
rs957529807 1739 dbSNP
rs534751983 1740 dbSNP
rs1254751459 1742 dbSNP
rs1344938548 1757 dbSNP
rs1335891679 1759 dbSNP
rs980705917 1760 dbSNP
rs926248629 1762 dbSNP
rs1456137083 1765 dbSNP
rs1177592556 1770 dbSNP
rs1267695650 1771 dbSNP
rs1434384636 1783 dbSNP
rs969195091 1784 dbSNP
rs368706787 1792 dbSNP
rs764200862 1792 dbSNP
rs753306305 1799 dbSNP
rs1172495655 1807 dbSNP
rs1397817159 1808 dbSNP
rs1464939975 1816 dbSNP
rs1330926476 1817 dbSNP
rs967435180 1821 dbSNP
rs565655360 1822 dbSNP
rs1475132380 1832 dbSNP
rs1014686069 1839 dbSNP
rs1014360205 1842 dbSNP
rs549905750 1845 dbSNP
rs1316443471 1848 dbSNP
rs1189700729 1871 dbSNP
rs1006272738 1880 dbSNP
rs754600525 1884 dbSNP
rs1265607000 1888 dbSNP
rs548811698 1890 dbSNP
rs1207513501 1903 dbSNP
rs751057941 1908 dbSNP
rs1477892129 1909 dbSNP
rs1195708863 1910 dbSNP
rs951764802 1914 dbSNP
rs1477363997 1922 dbSNP
rs766060066 1923 dbSNP
rs1027176153 1924 dbSNP
rs1350616115 1933 dbSNP
rs1459667116 1949 dbSNP
rs1014870647 1952 dbSNP
rs1390078379 1953 dbSNP
rs544607145 1960 dbSNP
rs1459334060 1961 dbSNP
rs1280634723 1966 dbSNP
rs1005178122 1975 dbSNP
rs1218335843 1977 dbSNP
rs890144543 1979 dbSNP
rs762475749 1980 dbSNP
rs1008402427 1987 dbSNP
rs1488326769 1989 dbSNP
rs1218231911 1990 dbSNP
rs1357663407 2000 dbSNP
rs1487923461 2009 dbSNP
rs144150306 2010 dbSNP
rs368288826 2014 dbSNP
rs1421886363 2015 dbSNP
rs1338380930 2026 dbSNP
rs900292863 2027 dbSNP
rs569219566 2053 dbSNP
rs77195936 2054 dbSNP
rs116547682 2055 dbSNP
rs565346192 2062 dbSNP
rs926111954 2063 dbSNP
rs1430674798 2065 dbSNP
rs1303986478 2066 dbSNP
rs1044993826 2067 dbSNP
rs1394717894 2070 dbSNP
rs947993780 2075 dbSNP
rs1409375056 2076 dbSNP
rs977717041 2082 dbSNP
rs374352729 2084 dbSNP
rs946268853 2085 dbSNP
rs546763092 2086 dbSNP
rs1210700636 2089 dbSNP
rs1239177385 2095 dbSNP
rs1482146214 2097 dbSNP
rs1181081826 2106 dbSNP
rs188551902 2107 dbSNP
rs1242693099 2110 dbSNP
rs1165112599 2111 dbSNP
rs1456420935 2112 dbSNP
rs1384869353 2113 dbSNP
rs1179427531 2115 dbSNP
rs62167034 2117 dbSNP
rs1441933789 2118 dbSNP
rs917845154 2123 dbSNP
rs1177414326 2134 dbSNP
rs1336487805 2134 dbSNP
rs1378531012 2134 dbSNP
rs1400237735 2134 dbSNP
rs61418485 2134 dbSNP
rs796916353 2134 dbSNP
rs528612503 2139 dbSNP
rs992369366 2148 dbSNP
rs940549684 2153 dbSNP
rs1375477109 2156 dbSNP
rs547411303 2157 dbSNP
rs1219365702 2158 dbSNP
rs1280575812 2171 dbSNP
rs1178391966 2173 dbSNP
rs1452738964 2174 dbSNP
rs1258495342 2181 dbSNP
rs958687908 2182 dbSNP
rs1034457426 2187 dbSNP
rs371527529 2192 dbSNP
rs907594772 2193 dbSNP
rs149967294 2197 dbSNP
rs963219347 2198 dbSNP
rs1015145861 2203 dbSNP
rs1191856254 2211 dbSNP
rs1427784264 2213 dbSNP
rs1004802357 2219 dbSNP
rs1413296531 2223 dbSNP
rs1240339845 2229 dbSNP
rs1176099322 2234 dbSNP
rs1355404428 2235 dbSNP
rs951702296 2236 dbSNP
rs1353573673 2251 dbSNP
rs890334473 2265 dbSNP
rs575567398 2269 dbSNP
rs1436491743 2276 dbSNP
rs773346029 2281 dbSNP
rs1276138157 2284 dbSNP
rs1030238723 2288 dbSNP
rs563599569 2290 dbSNP
rs995840141 2291 dbSNP
rs974383209 2296 dbSNP
rs772525411 2299 dbSNP
rs1331640894 2304 dbSNP
rs528468284 2305 dbSNP
rs1019836632 2311 dbSNP
rs544988576 2312 dbSNP
rs1053499006 2313 dbSNP
rs1477109179 2315 dbSNP
rs764993189 2318 dbSNP
rs185031389 2319 dbSNP
rs1478974339 2321 dbSNP
rs1042239247 2322 dbSNP
rs946328435 2324 dbSNP
rs917524522 2325 dbSNP
rs564374801 2328 dbSNP
rs1347582784 2329 dbSNP
rs552963435 2332 dbSNP
rs903850518 2343 dbSNP
rs1045050948 2345 dbSNP
rs1379907025 2348 dbSNP
rs139030565 2353 dbSNP
rs573721192 2356 dbSNP
rs192234571 2357 dbSNP
rs1216688324 2360 dbSNP
rs536452315 2361 dbSNP
rs189644742 2362 dbSNP
rs1264443582 2370 dbSNP
rs1223022707 2372 dbSNP
rs1191896582 2379 dbSNP
rs1372846519 2384 dbSNP
rs530918729 2386 dbSNP
rs1276549058 2387 dbSNP
rs1158725881 2389 dbSNP
rs1362333225 2390 dbSNP
rs1398093269 2393 dbSNP
rs940501454 2396 dbSNP
rs907730349 2405 dbSNP
rs550877647 2406 dbSNP
rs1030689705 2407 dbSNP
rs1357559340 2408 dbSNP
rs996038024 2409 dbSNP
rs1245289757 2410 dbSNP
rs538980897 2410 dbSNP
rs112925688 2418 dbSNP
rs1358904094 2422 dbSNP
rs192340597 2433 dbSNP
rs1415419364 2435 dbSNP
rs542464897 2438 dbSNP
rs1171183246 2441 dbSNP
rs902227337 2442 dbSNP
rs1424942556 2443 dbSNP
rs1190069906 2444 dbSNP
rs1193804155 2448 dbSNP
rs1478488834 2449 dbSNP
rs1443659516 2451 dbSNP
rs187764976 2453 dbSNP
rs1417363401 2456 dbSNP
rs1214547219 2458 dbSNP
rs1442636297 2460 dbSNP
rs561440802 2461 dbSNP
rs549172789 2465 dbSNP
rs1380795834 2482 dbSNP
rs1226600610 2483 dbSNP
rs1322780667 2483 dbSNP
rs1057401825 2484 dbSNP
rs1220572344 2485 dbSNP
rs1237051444 2486 dbSNP
rs930433916 2505 dbSNP
rs1338452415 2508 dbSNP
rs937553111 2509 dbSNP
rs1449119838 2515 dbSNP
rs927279541 2517 dbSNP
rs1361101583 2519 dbSNP
rs1239690879 2522 dbSNP
rs1332665056 2523 dbSNP
rs1037668742 2524 dbSNP
rs530742485 2531 dbSNP
rs1478980441 2536 dbSNP
rs1405040850 2540 dbSNP
rs1466006102 2541 dbSNP
rs1401690386 2544 dbSNP
rs1402743961 2546 dbSNP
rs942032249 2547 dbSNP
rs1306433703 2548 dbSNP
rs1332135873 2549 dbSNP
rs1236045098 2552 dbSNP
rs1281976458 2553 dbSNP
rs370170325 2557 dbSNP
rs1466735668 2563 dbSNP
rs907990091 2564 dbSNP
rs1259525808 2568 dbSNP
rs575119166 2570 dbSNP
rs545304390 2571 dbSNP
rs1194689126 2574 dbSNP
rs141622290 2578 dbSNP
rs182783239 2579 dbSNP
rs1460670913 2585 dbSNP
rs1428581168 2587 dbSNP
rs921693094 2594 dbSNP
rs762316770 2615 dbSNP
rs771659810 2615 dbSNP
rs974350581 2615 dbSNP
rs965701063 2617 dbSNP
rs192159207 2628 dbSNP
rs1031975853 2629 dbSNP
rs957082273 2635 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000392869.2 | 3UTR | ACUGGGGAGGCUGAGGCAGGAGAAUGGCGUGAACCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000392869.2 | 3UTR | ACUGGGGAGGCUGAGGCAGGAGAAUGGCGUGAACCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000392869.2 | 3UTR | UACUGGGGAGGCUGAGGCAGGAGAAUGGCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.279 0.01 0.305 0 84 Click to see details
THCA 0.3 0.01 0.153 0.12 59 Click to see details
KICH 0.282 0.09 0.183 0.19 25 Click to see details
CHOL 0.456 0.11 0.450 0.11 9 Click to see details
LIHC 0.16 0.14 0.166 0.13 49 Click to see details
STAD 0.159 0.19 0.023 0.45 32 Click to see details
KIRC 0.095 0.22 0.136 0.13 68 Click to see details
ESCA -0.17 0.31 -0.227 0.25 11 Click to see details
UCEC 0.107 0.33 0.158 0.26 19 Click to see details
PRAD 0.043 0.38 0.086 0.28 50 Click to see details
BLCA -0.061 0.4 -0.123 0.31 18 Click to see details
KIRP 0.043 0.41 -0.017 0.46 32 Click to see details
LUSC -0.032 0.42 -0.026 0.44 38 Click to see details
LUAD -0.056 0.43 -0.028 0.47 12 Click to see details
CESC -0.151 0.45 -0.500 0.33 3 Click to see details
PCPG 0.121 0.46 0.500 0.33 3 Click to see details
PAAD 0.042 0.48 -0.200 0.4 4 Click to see details
HNSC -0.006 0.48 -0.027 0.43 42 Click to see details
HNSC -0.006 0.48 -0.027 0.43 42 Click to see details
164 hsa-miR-2355-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT190653 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT286477 TAOK1 TAO kinase 1 2 4
MIRT318993 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT345622 DCAF7 DDB1 and CUL4 associated factor 7 2 4
MIRT442513 SYT7 synaptotagmin 7 2 4
MIRT444247 CTNND1 catenin delta 1 2 2
MIRT444780 ECE1 endothelin converting enzyme 1 2 2
MIRT456525 TMEM63A transmembrane protein 63A 2 2
MIRT468960 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT469834 R3HDM4 R3H domain containing 4 2 2
MIRT470027 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT471167 PHB2 prohibitin 2 2 2
MIRT475819 HDGF heparin binding growth factor 2 4
MIRT479389 CDKN1B cyclin dependent kinase inhibitor 1B 2 6
MIRT481747 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT485220 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT487259 CCNF cyclin F 2 2
MIRT489971 MCC mutated in colorectal cancers 2 4
MIRT491399 C1D C1D nuclear receptor corepressor 2 2
MIRT494959 CCDC144A coiled-coil domain containing 144A 2 4
MIRT494979 PPP5D1 PPP5 tetratricopeptide repeat domain containing 1 2 2
MIRT495225 CHST14 carbohydrate sulfotransferase 14 2 2
MIRT496550 TBX15 T-box 15 2 2
MIRT501612 PISD phosphatidylserine decarboxylase 2 2
MIRT509393 TRIM24 tripartite motif containing 24 2 2
MIRT519616 ZNF788 zinc finger family member 788 2 4
MIRT519738 ZNF394 zinc finger protein 394 2 4
MIRT521230 SAR1A secretion associated Ras related GTPase 1A 2 4
MIRT521801 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT526233 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526932 CMSS1 cms1 ribosomal small subunit homolog (yeast) 2 2
MIRT529189 ACBD7 acyl-CoA binding domain containing 7 2 2
MIRT529329 ZNF649 zinc finger protein 649 2 2
MIRT529698 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529921 TOP1MT DNA topoisomerase I mitochondrial 2 2
MIRT530032 SMC1A structural maintenance of chromosomes 1A 2 2
MIRT530898 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT531621 TM4SF5 transmembrane 4 L six family member 5 2 4
MIRT533132 XIAP X-linked inhibitor of apoptosis 2 2
MIRT533210 WAPAL WAPL cohesin release factor 2 2
MIRT534058 ST6GALNAC3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 2 2
MIRT535487 PARVB parvin beta 2 2
MIRT536749 HOXD9 homeobox D9 2 2
MIRT551456 CARKD NAD(P)HX dehydratase 2 2
MIRT551858 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT552095 FAM8A1 family with sequence similarity 8 member A1 2 2
MIRT552332 ZNF704 zinc finger protein 704 2 2
MIRT552549 ZFP36L2 ZFP36 ring finger protein like 2 2 2
MIRT561505 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT562702 ZNF415 zinc finger protein 415 2 2
MIRT563052 ZNF138 zinc finger protein 138 2 2
MIRT564592 ZNF791 zinc finger protein 791 2 2
MIRT566422 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 2
MIRT570176 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT570866 ZNF525 zinc finger protein 525 2 2
MIRT570875 ZFP1 ZFP1 zinc finger protein 2 2
MIRT571517 ZNF625 zinc finger protein 625 2 2
MIRT572551 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT610894 HINFP histone H4 transcription factor 2 2
MIRT611037 PTGES prostaglandin E synthase 2 2
MIRT611479 HSPA4 heat shock protein family A (Hsp70) member 4 2 4
MIRT612419 SP1 Sp1 transcription factor 2 2
MIRT614478 FRMPD3 FERM and PDZ domain containing 3 2 2
MIRT616318 CACNA1A calcium voltage-gated channel subunit alpha1 A 2 2
MIRT616929 ZNF638 zinc finger protein 638 2 2
MIRT618131 GABARAPL3 GABA type A receptor associated protein like 3 pseudogene 2 2
MIRT618452 ZFP30 ZFP30 zinc finger protein 2 4
MIRT620671 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620713 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT621126 EMC7 ER membrane protein complex subunit 7 2 4
MIRT621443 TOMM22 translocase of outer mitochondrial membrane 22 2 2
MIRT623491 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623783 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT623918 FNBP1L formin binding protein 1 like 2 2
MIRT625723 CXorf38 chromosome X open reading frame 38 2 2
MIRT625778 GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2 2
MIRT626940 TTR transthyretin 2 2
MIRT627357 TSC22D2 TSC22 domain family member 2 2 2
MIRT632078 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT633361 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT639793 MVK mevalonate kinase 2 2
MIRT643761 NAGK N-acetylglucosamine kinase 2 2
MIRT644358 NDUFAF6 NADH:ubiquinone oxidoreductase complex assembly factor 6 2 2
MIRT645558 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT646588 ANKRD36 ankyrin repeat domain 36 2 2
MIRT646631 SLC25A46 solute carrier family 25 member 46 2 2
MIRT648066 HSPA6 heat shock protein family A (Hsp70) member 6 2 2
MIRT648142 SUCLG2 succinate-CoA ligase GDP-forming beta subunit 2 2
MIRT648416 MYOZ3 myozenin 3 2 2
MIRT649218 AMMECR1L AMMECR1 like 2 2
MIRT649772 MRPS27 mitochondrial ribosomal protein S27 2 4
MIRT650510 UFM1 ubiquitin fold modifier 1 2 2
MIRT651007 ZNF740 zinc finger protein 740 2 2
MIRT651524 WNT2B Wnt family member 2B 2 2
MIRT652014 TTYH3 tweety family member 3 2 2
MIRT652513 TMEM109 transmembrane protein 109 2 2
MIRT652686 THUMPD3 THUMP domain containing 3 2 2
MIRT652772 TENM3 teneurin transmembrane protein 3 2 2
MIRT653160 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT653765 SIX5 SIX homeobox 5 2 2
MIRT653792 SIRPA signal regulatory protein alpha 2 2
MIRT655649 OAZ2 ornithine decarboxylase antizyme 2 2 2
MIRT656263 MEX3A mex-3 RNA binding family member A 2 2
MIRT657044 KCNH6 potassium voltage-gated channel subfamily H member 6 2 2
MIRT657375 HMGA1 high mobility group AT-hook 1 2 2
MIRT657532 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT657542 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657828 GJD3 gap junction protein delta 3 2 2
MIRT658946 DOK6 docking protein 6 2 2
MIRT660363 BACH2 BTB domain and CNC homolog 2 2 2
MIRT660406 ATXN7L3 ataxin 7 like 3 2 2
MIRT660948 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661031 AAK1 AP2 associated kinase 1 2 2
MIRT662435 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT668419 FAM217B family with sequence similarity 217 member B 2 2
MIRT669332 BSND barttin CLCNK type accessory beta subunit 2 2
MIRT676105 CLUAP1 clusterin associated protein 1 2 2
MIRT677084 SMIM15 small integral membrane protein 15 2 2
MIRT677127 OGFOD3 2-oxoglutarate and iron dependent oxygenase domain containing 3 2 2
MIRT678001 CPM carboxypeptidase M 2 2
MIRT678531 TMEM78 transmembrane protein 78 2 2
MIRT680000 ZNF860 zinc finger protein 860 2 2
MIRT680098 PXMP4 peroxisomal membrane protein 4 2 2
MIRT686795 SOX12 SRY-box 12 2 2
MIRT698887 SPTBN2 spectrin beta, non-erythrocytic 2 2 2
MIRT699371 SLC30A6 solute carrier family 30 member 6 2 2
MIRT702005 MIDN midnolin 2 2
MIRT708101 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT709563 GYG2 glycogenin 2 2 2
MIRT710559 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT710585 CDCA4 cell division cycle associated 4 2 2
MIRT710873 NT5DC1 5'-nucleotidase domain containing 1 2 2
MIRT711876 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712226 RIMS3 regulating synaptic membrane exocytosis 3 2 2
MIRT713211 FAM13A family with sequence similarity 13 member A 2 2
MIRT713261 GPR55 G protein-coupled receptor 55 2 2
MIRT713327 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT713889 RNF19B ring finger protein 19B 2 2
MIRT714015 UBAP2L ubiquitin associated protein 2 like 2 2
MIRT714202 NLRP12 NLR family pyrin domain containing 12 2 2
MIRT714717 VPS8 VPS8, CORVET complex subunit 2 2
MIRT714748 ZNF385D zinc finger protein 385D 2 2
MIRT714806 ARHGEF19 Rho guanine nucleotide exchange factor 19 2 2
MIRT714852 ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 2 2
MIRT715717 MRPL4 mitochondrial ribosomal protein L4 2 2
MIRT715852 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT716853 MFSD12 major facilitator superfamily domain containing 12 2 2
MIRT717134 EBPL emopamil binding protein like 2 2
MIRT717248 TMEM246 transmembrane protein 246 2 2
MIRT717997 ZNF79 zinc finger protein 79 2 2
MIRT718341 PURA purine rich element binding protein A 2 2
MIRT719587 TFCP2L1 transcription factor CP2 like 1 2 2
MIRT720520 PTGR2 prostaglandin reductase 2 2 2
MIRT720671 SLC39A13 solute carrier family 39 member 13 2 2
MIRT721213 DCLK3 doublecortin like kinase 3 2 2
MIRT721757 INF2 inverted formin, FH2 and WH2 domain containing 2 2
MIRT721826 POU6F1 POU class 6 homeobox 1 2 2
MIRT722091 SUSD1 sushi domain containing 1 2 2
MIRT722275 LURAP1 leucine rich adaptor protein 1 2 2
MIRT722802 ARHGAP19 Rho GTPase activating protein 19 2 2
MIRT722866 FAM212B family with sequence similarity 212 member B 2 2
MIRT723113 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT724378 NEK8 NIMA related kinase 8 2 2
MIRT732775 PYCR1 pyrroline-5-carboxylate reductase 1 3 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2355 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2355-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-2355-5p Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-2355-5p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, HCC827)
hsa-miR-2355-5p Gefitinib 123631 NSC715055 approved resistant High Non-Small Cell Lung Cancer cell line (A549, HCC827)
hsa-miR-2355-5p Temozolomide 5394 NSC362856 approved resistant High Glioma tissue
hsa-miR-2355-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-2355-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-2355-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2355-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2355-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)
hsa-miR-2355-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVSAHO)

Error report submission