miRTarBase - #MIRT657830


—
pre-miRNA Information
pre-miRNA hsa-mir-6509   
Genomic Coordinates chr7: 135206994 - 135207078
Description Homo sapiens miR-6509 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6509-3p
Sequence 52| UUCCACUGCCACUACCUAAUUU |73
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778601614 1 dbSNP
rs754554776 3 dbSNP
rs767798995 3 dbSNP
rs145322812 4 dbSNP
rs773941257 5 dbSNP
rs768273593 9 dbSNP
rs984565062 12 dbSNP
rs748872915 13 dbSNP
rs774861125 14 dbSNP
rs13241975 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GJD3   
Synonyms CX31.9, Cx30.2, GJA11, GJC1
Description gap junction protein delta 3
Transcript NM_152219   
Expression
Putative miRNA Targets on GJD3
3'UTR of GJD3
(miRNA target sites are highlighted)		 
>GJD3|NM_152219|3'UTR
   1 GGGCGGGCACCGCCTCGCGCGGACTGGACGGCGAGGGCCGGACCCCGCCACCTCCGCCCGCACCGCAGAAGCCGGAAGCT
  81 GCTTCCACCAGAGCTGTCGCGGGACCTGCCCCGGCAGGAGACGCGTTGTGGGGACGGCCCGCGGGCGGCATCGCACTTGC
 161 CTCGTACTGCCTCCCAGTGGCTGCCGGCGGCACCTGGGGCAGGCCGGGCTGGGGGCGGAGAATGAACTCAGGCAGGTCCT
 241 GGATGCCACCACCCAGGTGGAAAGGAAGGAGACCAGGACCCTGAGAGAGAGTGGACCCGAGGGGGAGAACAGAGCGGAAG
 321 GTGGAGAGTGGTTGTTTTACTGGGGACAAAAACAACTGTGATGCCAGCATTCTCAGGCACTCTCTGTGTTCAGAGAGAGA
 401 GTGGTCCCCCTGTGGGCTCTCTGCGAGTGTGCATACACGGACACATAAGCACTGTGAGCTGTGTGCACGCGCACCTGTAC
 481 ACCCTGTGTGAGCGCTGTGCATGTGCGCGCATGTGTACACCCTGCGTGAGGCCCACTTGTGCACACAGACACACGTAACC
 561 CTCCCGGGTGAGCTGTGTGCACATGCACACAGAAACATATGCCCCTTGAGAGCTGTGTACTCACATCCCTGTGAGCTTTG
 641 TGTGAGTGCATTGTGCACACACGCACATGTCCATTCTGTGTGGGCTGCGTGTGCACACCTGTACACAGAAACATCCTTGT
 721 GCGCTATGTGTGCATGTGTACATCCGGCGTGACCTCTGTGTGTGCACGCGTGTGTGTGTGATCTCTGATATGCACTGCGG
 801 GGGTGGCCAGGATCCGATGCCAGCTGCAGCCACAATGGCTCCCTCCCTACCACCCTAACCCAGCCCACCTGCCAGGGCAT
 881 CACAGGAGGTCTGTCCCCCCCTCCCAAGAGACCCCGCCCAGGGAGGGAAGAGGAGGAGAGGCTCCCTTTCCCCGGGCAGG
 961 CCTCAATCCTCGGGAGCCTATGAGCAACATCCTCACAGTACCCCTTGTGGCGAGGCGGGGGCTGGGCGCTTTCATGGAGG
1041 TGGGGTGGGGGTGGGCGGCGGGCCAGAGGGCAACCCAGACGTGTGTTATGCCTCCCTCCTCCATCTTCATCCTCCCCGCC
1121 GCTACTGCTCCCCCAGGCTATAAACGGGAAAGTCCCTTCTGTCCTCAGGAGAAAGCTCCCAAAACACACGCGCTCCCGGC
1201 CCTGCCTTCCCTTCCAACCACCCCCTTCTTCCTACTTGCGGGCATTCGAAGAGCTGCTGCCTATGCAGCGCATCCCCCTC
1281 CTGTGTCTCCCCTCCCGTCTGCCCTCCCCCTTCACCAGCCAGTGGGCTGCTCTCCATAAGATCACCCAGGACCTAAGCGA
1361 GAAATCCAGGGGCCGTCATCGGACTGCACCTTGCGGGCCTCACCGCATCCTGCCTACCAGGCTGTGCGTTCCCCGCCATC
1441 ACCCCACCCTGTCCTTCTGAGTTCCTGGCGTCTTTCTCAGCTCTCCTGTGCCCCACACAGCAGTGGGAGGTGTTTCTGAA
1521 TAGCGCCCCCCACTTAAACCCGGGACTGAGGGCAGCACCCCTGCCCTCAGGGTGAGTCAAGCGCCTTCACAAAGCTTCCT
1601 TCTGAAGCCCTGCCCCTGTCAGGCCTTCGACTCCACAGCACCGGCTTCCAGGTGTGCTCAGAACCATAGGGAATTTTCTC
1681 TTCTAACAAGCACCAGACCTGCTTGCTGCCAAGCGTTTGAACGTGCTGTTCCTTTGCCCAGAGTAGCCGCTGCTTCCTGC
1761 AGCCTTCTCCTCCCCTAGCTAATGCCCACCCACCTATTGTTGTCACTTGGGAAGAAAACAGACACCTTCAAGGAGAGGGC
1841 TCCCCTGGTAGCCCCCACCCCAAGACAGAGCTGGATGCCCCTCGCTTCCGTAGGGAAAGCACTTCTCCTGCAGGATGGCA
1921 TTGCTCTCTCCCCTTCCATGGCACGTAGTATGTGCTCAGTAAATATGTGTTGGATGAGAAACTGAAGGTGTCCCCAGGCC
2001 TACACCACTGCCATGCCCGAACACTATCCATGCTATGGTGGGCACCATCTCTCTGATGACAGTTCTGTGTCCACAACCCA
2081 GACCCCTCCACACAAACCCAGATGGGGCTGTGCCGCTGTTTTCCAGATGTATTCATTCAACAAATATTTGTAGGGTACCT
2161 ACTGTGTGTCAGAAGATGTTCAAGATCAGCATCATCCGATGGAAATAGCATATGAGCCATGTATGTAGTTTCAAGTTTTT
2241 CATTAGCCACATTAAAAAAGTAAAAGGAAACAAATGAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuuaauccaucacCGUCACCUu 5'
                       |||||||: 
Target 5' tgtgccccacacaGCAGTGGGa 3'
 1487 - 1508 129.00 -14.30
2 
miRNA  3' uuuaauccaucaCCGUCACCUu 5'
                      | ||||||: 
Target 5' cccccttcaccaGCCAGTGGGc 3'
 1306 - 1327 126.00 -9.20
3 
miRNA  3' uuuaaucCAUCAC----CGUCACCuu 5'
                 ||| ||     ||||||  
Target 5' ttgcctcGTACTGCCTCCCAGTGGct 3'
 157 - 182 125.00 -8.10
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs113726170 3 dbSNP
rs999721985 4 dbSNP
rs1212699937 8 dbSNP
rs561145608 15 dbSNP
rs1464405283 16 dbSNP
rs1042845015 17 dbSNP
rs1274536270 20 dbSNP
rs1226079709 21 dbSNP
rs1317869964 25 dbSNP
rs1416231429 29 dbSNP
rs1284497331 37 dbSNP
rs1487024562 43 dbSNP
rs1011279518 44 dbSNP
rs994140563 50 dbSNP
rs1473598128 52 dbSNP
rs542817521 53 dbSNP
rs1474242547 58 dbSNP
rs1412874141 60 dbSNP
rs796724390 64 dbSNP
rs1248066197 78 dbSNP
rs1055395918 81 dbSNP
rs1358485995 82 dbSNP
rs572361259 88 dbSNP
rs1334876177 89 dbSNP
rs1360929992 95 dbSNP
rs1446149078 98 dbSNP
rs930753037 100 dbSNP
rs1378198832 104 dbSNP
rs920703601 108 dbSNP
rs1036671644 112 dbSNP
rs1039506039 113 dbSNP
rs1200457835 118 dbSNP
rs1318433651 129 dbSNP
rs942544640 130 dbSNP
rs911047871 132 dbSNP
rs1443631029 136 dbSNP
rs986717941 140 dbSNP
rs1212839738 142 dbSNP
rs909035232 150 dbSNP
rs1275637400 153 dbSNP
rs1458059564 156 dbSNP
rs984582029 159 dbSNP
rs1439048676 160 dbSNP
rs1173064348 161 dbSNP
rs781295904 162 dbSNP
rs1412828758 163 dbSNP
rs1401229310 164 dbSNP
rs1449493528 166 dbSNP
rs912917303 176 dbSNP
rs1376599993 183 dbSNP
rs554460584 185 dbSNP
rs1448196308 188 dbSNP
rs976100038 195 dbSNP
rs957234851 199 dbSNP
rs1216917993 209 dbSNP
rs1032763069 210 dbSNP
rs966016613 214 dbSNP
rs186791428 219 dbSNP
rs970250400 230 dbSNP
rs1031280355 237 dbSNP
rs1000177893 238 dbSNP
rs1024477594 241 dbSNP
rs968285462 248 dbSNP
rs1022888784 252 dbSNP
rs1453348906 256 dbSNP
rs1393048377 268 dbSNP
rs1012336084 271 dbSNP
rs370184193 298 dbSNP
rs577946427 300 dbSNP
rs1180220475 301 dbSNP
rs1172023100 302 dbSNP
rs1458182848 310 dbSNP
rs1232203412 316 dbSNP
rs1014540541 321 dbSNP
rs556317250 322 dbSNP
rs1400109289 323 dbSNP
rs1048417970 326 dbSNP
rs768888158 331 dbSNP
rs1279342288 344 dbSNP
rs1326123007 352 dbSNP
rs1329803258 357 dbSNP
rs538332234 358 dbSNP
rs1433710843 359 dbSNP
rs1233865060 374 dbSNP
rs1345934386 379 dbSNP
rs1311960324 381 dbSNP
rs1340576393 384 dbSNP
rs1241292431 386 dbSNP
rs1255757690 392 dbSNP
rs747155274 398 dbSNP
rs182077639 400 dbSNP
rs549152261 401 dbSNP
rs751040394 402 dbSNP
rs1439478821 406 dbSNP
rs1198562079 407 dbSNP
rs1360389214 410 dbSNP
rs994866390 414 dbSNP
rs193258767 415 dbSNP
rs1433734424 420 dbSNP
rs1373195463 421 dbSNP
rs1458754023 425 dbSNP
rs1165319972 427 dbSNP
rs1388981476 428 dbSNP
rs940604470 435 dbSNP
rs1299334935 439 dbSNP
rs899122746 451 dbSNP
rs113876371 454 dbSNP
rs1039152531 455 dbSNP
rs943454152 472 dbSNP
rs1275930200 473 dbSNP
rs911076917 474 dbSNP
rs780341429 488 dbSNP
rs1325439632 491 dbSNP
rs1245284623 493 dbSNP
rs1285773788 497 dbSNP
rs1050871126 502 dbSNP
rs1221744866 521 dbSNP
rs552476516 522 dbSNP
rs1407239439 524 dbSNP
rs913164656 525 dbSNP
rs533110960 526 dbSNP
rs989092595 550 dbSNP
rs935685833 552 dbSNP
rs1367150801 555 dbSNP
rs1473704539 559 dbSNP
rs1238148385 560 dbSNP
rs1210202683 561 dbSNP
rs1484837697 566 dbSNP
rs1362945157 572 dbSNP
rs1421012488 578 dbSNP
rs1295771569 580 dbSNP
rs1288403961 583 dbSNP
rs1383578148 585 dbSNP
rs1396300065 588 dbSNP
rs562497551 592 dbSNP
rs550209221 600 dbSNP
rs922035217 603 dbSNP
rs1338490490 604 dbSNP
rs528911672 610 dbSNP
rs1244898106 628 dbSNP
rs976151439 629 dbSNP
rs1237827996 645 dbSNP
rs1355713655 645 dbSNP
rs561458368 657 dbSNP
rs1316695286 661 dbSNP
rs966105000 662 dbSNP
rs1230539170 663 dbSNP
rs1483609510 665 dbSNP
rs532772535 666 dbSNP
rs923933623 668 dbSNP
rs115475812 673 dbSNP
rs570212474 678 dbSNP
rs968713798 680 dbSNP
rs1158990706 682 dbSNP
rs1466044283 684 dbSNP
rs1173982291 689 dbSNP
rs1022517207 712 dbSNP
rs1451686480 722 dbSNP
rs1353231849 723 dbSNP
rs1331833447 726 dbSNP
rs1378804307 728 dbSNP
rs979890653 738 dbSNP
rs969778729 742 dbSNP
rs1312855722 743 dbSNP
rs1024508752 745 dbSNP
rs1254509789 746 dbSNP
rs1323045510 756 dbSNP
rs1344402201 758 dbSNP
rs1002571863 765 dbSNP
rs1034092107 765 dbSNP
rs1177139866 767 dbSNP
rs1268596541 768 dbSNP
rs993010552 769 dbSNP
rs1177553087 775 dbSNP
rs950924694 776 dbSNP
rs1407044321 781 dbSNP
rs367751199 784 dbSNP
rs1187377496 786 dbSNP
rs995489554 790 dbSNP
rs899204081 791 dbSNP
rs1004521322 793 dbSNP
rs1018003487 802 dbSNP
rs547132886 805 dbSNP
rs1485630585 811 dbSNP
rs1259356927 816 dbSNP
rs1297556265 820 dbSNP
rs1368157044 822 dbSNP
rs560549224 823 dbSNP
rs1051772939 824 dbSNP
rs931830664 836 dbSNP
rs1344942029 842 dbSNP
rs1273083773 844 dbSNP
rs1260162143 850 dbSNP
rs1316462343 859 dbSNP
rs1204205080 860 dbSNP
rs188673813 868 dbSNP
rs1266577845 870 dbSNP
rs1489776020 877 dbSNP
rs779552524 878 dbSNP
rs1189958726 886 dbSNP
rs1232211852 895 dbSNP
rs1479819568 895 dbSNP
rs933826729 897 dbSNP
rs1040519118 899 dbSNP
rs578215818 900 dbSNP
rs1365110032 901 dbSNP
rs1360793461 902 dbSNP
rs944790919 902 dbSNP
rs1280359215 912 dbSNP
rs1338654177 915 dbSNP
rs1214171970 920 dbSNP
rs1286942823 920 dbSNP
rs1323862922 922 dbSNP
rs1438322298 926 dbSNP
rs1395208143 927 dbSNP
rs757891121 929 dbSNP
rs1490048618 930 dbSNP
rs1053078464 935 dbSNP
rs1216646296 938 dbSNP
rs1264925201 939 dbSNP
rs1474247377 940 dbSNP
rs1185551339 942 dbSNP
rs978510595 953 dbSNP
rs1425887385 954 dbSNP
rs1425331721 958 dbSNP
rs4420582 960 dbSNP
rs1428170066 966 dbSNP
rs915519986 971 dbSNP
rs991021354 972 dbSNP
rs1430347217 976 dbSNP
rs538246358 977 dbSNP
rs1303636564 988 dbSNP
rs1193334597 997 dbSNP
rs959567986 1001 dbSNP
rs1489003779 1002 dbSNP
rs749911669 1003 dbSNP
rs1355004523 1005 dbSNP
rs5019478 1012 dbSNP
rs1459445324 1017 dbSNP
rs971565938 1017 dbSNP
rs1214715103 1022 dbSNP
rs1259468663 1024 dbSNP
rs1237626849 1026 dbSNP
rs1484125180 1033 dbSNP
rs1227479332 1034 dbSNP
rs1306611991 1035 dbSNP
rs1292984850 1038 dbSNP
rs1220805461 1039 dbSNP
rs1242268481 1040 dbSNP
rs1371471314 1041 dbSNP
rs1324910983 1042 dbSNP
rs1160366699 1043 dbSNP
rs1038319249 1046 dbSNP
rs1405965265 1046 dbSNP
rs1402315203 1047 dbSNP
rs1005881624 1052 dbSNP
rs905732540 1056 dbSNP
rs1014651561 1057 dbSNP
rs1371613995 1057 dbSNP
rs1178498304 1059 dbSNP
rs1454823127 1060 dbSNP
rs1004977277 1061 dbSNP
rs1394868404 1062 dbSNP
rs1192100360 1064 dbSNP
rs1459510865 1065 dbSNP
rs1278292555 1068 dbSNP
rs1347930382 1081 dbSNP
rs887438292 1082 dbSNP
rs879412741 1087 dbSNP
rs1313627961 1089 dbSNP
rs1044590852 1110 dbSNP
rs949834207 1113 dbSNP
rs996091583 1115 dbSNP
rs948340517 1118 dbSNP
rs917021856 1120 dbSNP
rs2923227 1122 dbSNP
rs1480024814 1132 dbSNP
rs534176 1136 dbSNP
rs1191807504 1139 dbSNP
rs1249046643 1140 dbSNP
rs183746603 1145 dbSNP
rs1468483120 1161 dbSNP
rs1348089275 1162 dbSNP
rs1175960486 1163 dbSNP
rs1302446256 1167 dbSNP
rs1231761108 1178 dbSNP
rs1379083499 1182 dbSNP
rs759109060 1189 dbSNP
rs950922458 1191 dbSNP
rs902615653 1193 dbSNP
rs1346830991 1197 dbSNP
rs1026895910 1214 dbSNP
rs1262047785 1222 dbSNP
rs973703625 1223 dbSNP
rs946738436 1224 dbSNP
rs1270838241 1233 dbSNP
rs1437210244 1236 dbSNP
rs1248592445 1239 dbSNP
rs963951530 1241 dbSNP
rs1017782682 1242 dbSNP
rs1007532515 1243 dbSNP
rs751115054 1252 dbSNP
rs1198970766 1270 dbSNP
rs191728195 1272 dbSNP
rs534316841 1276 dbSNP
rs1479020896 1287 dbSNP
rs1010056261 1290 dbSNP
rs938271603 1299 dbSNP
rs566645628 1308 dbSNP
rs982703912 1309 dbSNP
rs916972025 1314 dbSNP
rs1366894209 1326 dbSNP
rs1375042685 1327 dbSNP
rs1282265003 1340 dbSNP
rs1340707221 1341 dbSNP
rs143200660 1358 dbSNP
rs1338494587 1369 dbSNP
rs1210430076 1373 dbSNP
rs1293771563 1381 dbSNP
rs1441917967 1385 dbSNP
rs1221782629 1392 dbSNP
rs757206706 1393 dbSNP
rs1364950438 1394 dbSNP
rs1449003316 1405 dbSNP
rs1191285772 1411 dbSNP
rs961546520 1412 dbSNP
rs1473290114 1413 dbSNP
rs1181728219 1414 dbSNP
rs1417796078 1415 dbSNP
rs1053346132 1417 dbSNP
rs907645487 1420 dbSNP
rs1422243726 1434 dbSNP
rs1247836081 1442 dbSNP
rs1189394000 1453 dbSNP
rs935963143 1455 dbSNP
rs983212884 1468 dbSNP
rs1315785282 1478 dbSNP
rs951729958 1486 dbSNP
rs1027325419 1498 dbSNP
rs1317106805 1500 dbSNP
rs1357141408 1512 dbSNP
rs539718761 1519 dbSNP
rs569062633 1521 dbSNP
rs1279132289 1522 dbSNP
rs995808894 1525 dbSNP
rs904453947 1526 dbSNP
rs550123143 1527 dbSNP
rs1355576133 1529 dbSNP
rs1261024812 1531 dbSNP
rs1443373972 1542 dbSNP
rs766355528 1553 dbSNP
rs1009171792 1556 dbSNP
rs1044313425 1558 dbSNP
rs1241655430 1570 dbSNP
rs1159772549 1573 dbSNP
rs1444617233 1573 dbSNP
rs1333858361 1576 dbSNP
rs1454833961 1577 dbSNP
rs1156459036 1581 dbSNP
rs1314991209 1582 dbSNP
rs541693638 1588 dbSNP
rs1415452455 1594 dbSNP
rs1396423467 1598 dbSNP
rs902333404 1610 dbSNP
rs1380286281 1616 dbSNP
rs1451908826 1618 dbSNP
rs1309805903 1623 dbSNP
rs1337622959 1623 dbSNP
rs1236905899 1625 dbSNP
rs948371355 1629 dbSNP
rs1346024375 1642 dbSNP
rs528876679 1643 dbSNP
rs1205786749 1645 dbSNP
rs1042902757 1649 dbSNP
rs1461145304 1650 dbSNP
rs112611379 1652 dbSNP
rs916884978 1655 dbSNP
rs1010990640 1658 dbSNP
rs1253215886 1661 dbSNP
rs1056940662 1665 dbSNP
rs1420377589 1674 dbSNP
rs929029927 1679 dbSNP
rs919460448 1696 dbSNP
rs1178998922 1699 dbSNP
rs893854823 1701 dbSNP
rs1055059062 1708 dbSNP
rs1470048176 1711 dbSNP
rs1178135073 1714 dbSNP
rs973992208 1715 dbSNP
rs567784912 1724 dbSNP
rs1331977905 1737 dbSNP
rs546265669 1738 dbSNP
rs1335069852 1744 dbSNP
rs1172096937 1747 dbSNP
rs528206417 1748 dbSNP
rs1392914219 1749 dbSNP
rs1365229496 1750 dbSNP
rs1324063311 1755 dbSNP
rs1225655559 1758 dbSNP
rs56041121 1760 dbSNP
rs1046628247 1772 dbSNP
rs1395545935 1774 dbSNP
rs1253629735 1778 dbSNP
rs940216658 1780 dbSNP
rs986309064 1784 dbSNP
rs1195718331 1785 dbSNP
rs908706901 1786 dbSNP
rs1167166479 1789 dbSNP
rs531524091 1791 dbSNP
rs545321987 1796 dbSNP
rs1183174856 1798 dbSNP
rs1426706952 1798 dbSNP
rs762651107 1800 dbSNP
rs773868161 1804 dbSNP
rs753834837 1811 dbSNP
rs1192571057 1813 dbSNP
rs186881946 1814 dbSNP
rs984655573 1817 dbSNP
rs775934973 1819 dbSNP
rs1030288365 1820 dbSNP
rs1210888602 1825 dbSNP
rs377397158 1827 dbSNP
rs1206264161 1832 dbSNP
rs951782398 1837 dbSNP
rs1391556021 1839 dbSNP
rs1349413802 1841 dbSNP
rs746077474 1842 dbSNP
rs1241114353 1853 dbSNP
rs956994527 1855 dbSNP
rs781383398 1856 dbSNP
rs1302379287 1857 dbSNP
rs1298252740 1858 dbSNP
rs775281780 1861 dbSNP
rs1227347128 1864 dbSNP
rs1371986578 1865 dbSNP
rs1328255813 1866 dbSNP
rs1490376876 1874 dbSNP
rs1380538104 1882 dbSNP
rs747070984 1884 dbSNP
rs778737141 1889 dbSNP
rs761776050 1890 dbSNP
rs1393845569 1891 dbSNP
rs1173375731 1896 dbSNP
rs1169679330 1899 dbSNP
rs1426453491 1899 dbSNP
rs1019308335 1901 dbSNP
rs776578831 1902 dbSNP
rs966986190 1903 dbSNP
rs1365015472 1910 dbSNP
rs1373131595 1912 dbSNP
rs1186285060 1919 dbSNP
rs1445858674 1926 dbSNP
rs1020791492 1928 dbSNP
rs1261846144 1929 dbSNP
rs143716047 1931 dbSNP
rs1012832063 1944 dbSNP
rs753632288 1945 dbSNP
rs1175378099 1951 dbSNP
rs1234744974 1955 dbSNP
rs574061081 1959 dbSNP
rs555834407 1963 dbSNP
rs1057188528 1966 dbSNP
rs1216076554 1969 dbSNP
rs1225551749 1970 dbSNP
rs779818411 1982 dbSNP
rs1484785968 1988 dbSNP
rs906535154 1989 dbSNP
rs1384043009 1995 dbSNP
rs1374156649 1996 dbSNP
rs1243497957 1998 dbSNP
rs928956607 1999 dbSNP
rs1393585731 2003 dbSNP
rs540713680 2005 dbSNP
rs1047126140 2018 dbSNP
rs940287292 2019 dbSNP
rs573306496 2026 dbSNP
rs908752366 2040 dbSNP
rs1343614082 2042 dbSNP
rs1461317742 2043 dbSNP
rs546146500 2046 dbSNP
rs1416540940 2049 dbSNP
rs1048569968 2052 dbSNP
rs1037414672 2054 dbSNP
rs1351808751 2056 dbSNP
rs1476207138 2057 dbSNP
rs1223810523 2074 dbSNP
rs1285949378 2078 dbSNP
rs1314806904 2080 dbSNP
rs942199199 2089 dbSNP
rs1373269138 2090 dbSNP
rs920367324 2098 dbSNP
rs34247423 2102 dbSNP
rs910710484 2102 dbSNP
rs986383974 2107 dbSNP
rs954942577 2112 dbSNP
rs182843306 2115 dbSNP
rs1242399271 2120 dbSNP
rs1470571375 2123 dbSNP
rs1179062215 2125 dbSNP
rs988562871 2128 dbSNP
rs956710087 2133 dbSNP
rs1032844322 2143 dbSNP
rs1405853756 2150 dbSNP
rs1400402180 2154 dbSNP
rs1000923898 2163 dbSNP
rs540702547 2164 dbSNP
rs968574750 2166 dbSNP
rs35530628 2174 dbSNP
rs1350488728 2175 dbSNP
rs1271385989 2176 dbSNP
rs1012866523 2191 dbSNP
rs796969688 2196 dbSNP
rs1280834734 2197 dbSNP
rs1370526095 2198 dbSNP
rs1057024502 2201 dbSNP
rs190215142 2206 dbSNP
rs567701064 2208 dbSNP
rs1325451637 2210 dbSNP
rs15685 2212 dbSNP
rs1037888329 2216 dbSNP
rs941780587 2225 dbSNP
rs1225777141 2235 dbSNP
rs1206516990 2243 dbSNP
rs1231315255 2245 dbSNP
rs746215561 2247 dbSNP
rs1050541676 2252 dbSNP
rs879157798 2254 dbSNP
rs528185342 2276 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000426548.1 | 3UTR | GAGGGAGAAGAGAGUGGCUUUGCCCAGUGGAAAGGCUGGGGAUUUGAGAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6509-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055374 PDCD4 programmed cell death 4 2 4
MIRT378341 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT444668 CDKL2 cyclin dependent kinase like 2 2 2
MIRT446953 CD248 CD248 molecule 2 2
MIRT460332 CAMK4 calcium/calmodulin dependent protein kinase IV 2 6
MIRT464078 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT464586 UBN2 ubinuclein 2 2 2
MIRT468482 SESN3 sestrin 3 2 2
MIRT468962 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT475455 HSPA8 heat shock protein family A (Hsp70) member 8 2 2
MIRT482403 ADRB1 adrenoceptor beta 1 2 10
MIRT486992 ZFAND2B zinc finger AN1-type containing 2B 2 2
MIRT489397 TUBB2A tubulin beta 2A class IIa 2 2
MIRT526319 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526560 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT526732 ZNF138 zinc finger protein 138 2 8
MIRT531581 STXBP5L syntaxin binding protein 5 like 2 2
MIRT532011 NOX5 NADPH oxidase 5 2 2
MIRT533407 TXLNG taxilin gamma 2 2
MIRT533436 TRPC5 transient receptor potential cation channel subfamily C member 5 2 2
MIRT533866 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT539254 ANKRD50 ankyrin repeat domain 50 2 2
MIRT541451 C15orf48 chromosome 15 open reading frame 48 2 2
MIRT566794 MIER3 MIER family member 3 2 2
MIRT569294 SURF6 surfeit 6 2 2
MIRT571336 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT572802 PPP3CB protein phosphatase 3 catalytic subunit beta 2 2
MIRT572813 MYO1C myosin IC 2 2
MIRT574219 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT607259 GRAMD1B GRAM domain containing 1B 2 4
MIRT609307 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT615459 REPS1 RALBP1 associated Eps domain containing 1 2 2
MIRT616861 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT619415 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT619652 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT625325 TNFRSF13B TNF receptor superfamily member 13B 2 2
MIRT638980 ARFIP2 ADP ribosylation factor interacting protein 2 2 2
MIRT639458 ZNF429 zinc finger protein 429 2 2
MIRT640550 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT641473 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT642720 ATXN3 ataxin 3 2 2
MIRT643048 SMN1 survival of motor neuron 1, telomeric 2 2
MIRT644921 SMN2 survival of motor neuron 2, centromeric 2 2
MIRT645875 ZNF275 zinc finger protein 275 2 2
MIRT649824 LIPG lipase G, endothelial type 2 2
MIRT649851 GYS2 glycogen synthase 2 2 2
MIRT649972 TRAFD1 TRAF-type zinc finger domain containing 1 2 2
MIRT650675 ZNF259 ZPR1 zinc finger 1 1
MIRT651319 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT652876 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT652881 SYVN1 synoviolin 1 2 2
MIRT654144 RPAP2 RNA polymerase II associated protein 2 2 2
MIRT657080 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657181 INO80C INO80 complex subunit C 2 2
MIRT657830 GJD3 gap junction protein delta 3 2 2
MIRT657897 GDF7 growth differentiation factor 7 2 2
MIRT659631 CDKN2AIP CDKN2A interacting protein 2 2
MIRT663115 SPTA1 spectrin alpha, erythrocytic 1 2 2
MIRT664739 METTL16 methyltransferase like 16 2 2
MIRT667551 LRAT lecithin retinol acyltransferase 2 2
MIRT668552 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT682893 XIAP X-linked inhibitor of apoptosis 2 2
MIRT683092 PRRG4 proline rich and Gla domain 4 2 2
MIRT683102 TIMM10B translocase of inner mitochondrial membrane 10B 2 2
MIRT697648 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT709158 ZNF419 zinc finger protein 419 2 2
MIRT713220 RCAN2 regulator of calcineurin 2 2 2
MIRT713277 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT715008 CYP1B1 cytochrome P450 family 1 subfamily B member 1 2 2
MIRT715051 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT715696 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT717250 TMEM246 transmembrane protein 246 2 2
MIRT717322 PGK1 phosphoglycerate kinase 1 2 2
MIRT717587 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like 2 2
MIRT718122 CHST4 carbohydrate sulfotransferase 4 2 2
MIRT718418 CALN1 calneuron 1 2 2
MIRT718750 ZNF490 zinc finger protein 490 2 2
MIRT720048 PPP1R3F protein phosphatase 1 regulatory subunit 3F 2 2
MIRT721497 THRB thyroid hormone receptor beta 2 2
MIRT722531 EPRS glutamyl-prolyl-tRNA synthetase 2 2
MIRT723279 KRTAP21-2 keratin associated protein 21-2 2 2
MIRT724813 MSX2 msh homeobox 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6509-3p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6509-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6509-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6509-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6509-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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